Reagent refrigeration device of immunohistochemical equipment

Abstract

The invention discloses a reagent refrigeration device of immunohistochemical equipment. The reagent refrigeration device comprises a mounting plate, a placement table connected to the mounting plate and a refrigeration assembly connected to the placement table, the placing table is used for storing kits, and the refrigeration assembly is used for conveying cold energy to the kits so as to realize refrigeration of reagents contained in the kits; the containing table comprises a flow guide groove used for guiding condensate, a flow baffle arranged at one end of the flow guide groove and a confluence groove formed in the other end of the flow guide groove. The bottom of the confluence groove is provided with a liquid discharge hole. According to the reagent cold storage device of the immunohistochemical equipment, a condensate collecting and discharging structure is additionally arranged, and condensate generated in the cold storage process can be effectively treated; a kit detection function is added, and the refrigeration function of the refrigeration module can be automatically opened or closed according to whether a kit exists or not, so that the energy consumption of the equipment is effectively reduced; a temperature detection function is added, the space temperature is detected in real time, and the power of the refrigeration sheet is automatically adjusted through temperature feedback.

Description

Technical Field

[0001] The present invention relates to the technical field of immunohistochemistry equipment, in particular to a reagent refrigeration device for immunohistochemistry equipment. Background Art

[0002] In recent years, immunohistochemistry equipment has become increasingly common in pathology departments. As sample volumes increase, the equipment must operate around the clock for slide preparation. Smaller reagents must be left open on the equipment. High ambient temperatures can cause significant volatilization of the reagents, resulting in reagent waste and a reduction in the number of slides that can be prepared, increasing production costs for users. A common solution is to simply add a cooling module to the reagent storage area to lower the reagent storage temperature and slow down the volatilization process. However, this approach often fails to address the issue of condensation, impacting the user experience. Summary of the Invention

[0003] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a reagent refrigeration device for immunohistochemistry equipment to solve the technical problem that the existing reagent kit refrigeration device cannot effectively handle condensation.

[0004] To achieve the above object, the present invention adopts the following technical solutions:

[0005] An embodiment of the present invention provides a reagent refrigeration device for immunohistochemistry equipment, comprising: a mounting plate, a placement table connected to the mounting plate, and a refrigeration component connected to the placement table;

[0006] The placement table is used to store the reagent kit, and the refrigeration component is used to deliver cold energy to the reagent kit to achieve refrigeration of the reagent contained in the reagent kit;

[0007] The placement table includes a guide groove for guiding condensate, a baffle arranged at one end of the guide groove, and a confluence groove arranged at the other end of the guide groove; a drainage hole is provided at the bottom of the confluence groove.

[0008] The guide grooves are a plurality of parallel linear grooves recessed on the top surface of the placement table, and both ends of the linear grooves extend to the baffle plate and the confluence groove respectively.

[0009] Wherein, the bottom of the confluence trough is lower than the bottom of the guide trough.

[0010] Wherein, the baffle is a step-shaped baffle, and the vertical protrusion height of the step-shaped baffle is 3-6 mm.

[0011] The bottom of the confluence groove is 0.5-1.2 mm lower than the bottom of the guide groove.

[0012] Wherein, the drainage hole is a circular through hole with a diameter of 2-3 mm.

[0013] Wherein, the placement table is further provided with a temperature detection sensor, and the temperature detection sensor is used to detect the temperature of the reagent box in real time to control the refrigeration power of the refrigeration component.

[0014] Wherein, a detection sensor for detecting whether the reagent kit is present is provided on the placement table, and the refrigeration component is used to start or stop refrigeration according to a signal from the detection sensor.

[0015] A collecting box is further provided on the mounting plate, which is connected to the drainage hole and is used to collect condensate. A straight pipe and an overflow pipe are also provided on the collecting box, and the vertical height of the overflow pipe is higher than that of the straight pipe.

[0016] Among them, the reagent refrigeration device of the immunohistochemistry equipment also includes an air supply component, the refrigeration component includes a semiconductor refrigeration plate and a heat sink, the semiconductor refrigeration plate abuts the bottom of the placement table, the heat sink abuts the semiconductor refrigeration plate, and the air supply component is used to supply air to the heat sink.

[0017] The reagent refrigeration device of the immunohistochemistry equipment of the present invention has an additional condensate collection and discharge structure, which can effectively handle the condensate generated during the refrigeration process; a reagent kit detection function is added, and the refrigeration module can automatically turn on or off the refrigeration function according to the presence or absence of a reagent kit, effectively reducing the energy consumption of the equipment; and a temperature detection function is added to detect the space temperature in real time and automatically adjust the refrigeration chip power through temperature feedback.

[0018] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present invention more obvious and easy to understand, the following preferred embodiments are specifically cited and described in detail as follows. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figures 1 to 4 Schematic diagram of the overall structure of the reagent refrigeration device of the immunohistochemistry equipment according to an embodiment of the present invention from different perspectives.

[0020] Figure 5 This is an exploded view of a reagent refrigeration device of an immunohistochemistry device according to an embodiment of the present invention.

[0021] Figure 6 This is a side view of a reagent refrigeration device of an immunohistochemistry device according to an embodiment of the present invention.

[0022] Figure 7 for Figure 6 AA sectional view is shown.

[0023] Figure 8 for Figure 7 Schematic diagram of the enlarged structure of part A in the middle.

[0024] Figure 9 for Figure 7 Schematic diagram of the enlarged structure of part B in the middle.

[0025] Description of reference numerals:

[0026] The reagent refrigeration device 100 of the immunohistochemistry equipment, the mounting plate 1, the placement table 2, the refrigeration module 3, the plate body 20, the baffle 21, the guide groove 22, the confluence groove 23, the drainage hole 24, the collection box 4, the container box 41, the straight pipe 42, the overflow pipe 43, the detection circuit board 5, the temperature detection sensor 6, the air supply component 31, the fan 311, the air duct plate 312, the heat dissipation pipe 313, the refrigeration component 32, the semiconductor refrigeration plate 321, and the heat dissipation plate 322. DETAILED DESCRIPTION

[0027] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0028] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making any creative efforts shall fall within the scope of protection of the present invention.

[0029] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like to indicate orientations or positional relationships based on the orientations or positional relationships described in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0030] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature identified as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.

[0031] In the present invention, unless otherwise expressly specified or limited, terms such as "mounted," "connected," "connect," and "fixed" should be understood broadly. For example, they may refer to connection, detachable connection, or integration; mechanical connection or electrical connection; direct connection or indirect connection through an intermediate medium; and internal communication between two components or interaction between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0032] In the present invention, unless otherwise expressly specified or limited, a first feature being "above" or "below" a second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Furthermore, a first feature being "above," "above," and "above" a second feature may include the first feature being directly above or obliquely above the second feature, or may simply mean that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature may include the first feature being directly below or obliquely below the second feature, or may simply mean that the first feature is lower in level than the second feature.

[0033] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. Throughout this specification, the schematic representations of these terms should not be construed as necessarily referring to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0034] In recent years, the use of immunohistochemistry equipment in pathology departments has become increasingly common. As the number of samples increases, the equipment needs to be used for slide preparation day and night. Some reagents with smaller usage amounts need to be placed on the equipment with the bottle mouths opened. If the ambient temperature is high, the reagents are likely to evaporate in large quantities, resulting in reagent waste, resulting in a reduction in the actual amount of slides that can be prepared with the reagents, thereby increasing the user's production costs. The usual solution is to simply add a refrigeration module to the reagent storage area to lower the temperature at which the reagents are stored, thereby achieving the purpose of slowing down the volatilization of the reagents. However, when adding a refrigeration module, the problem of condensate is not well solved, which affects the user experience of the equipment. Therefore, based on the above needs, this embodiment provides a reagent refrigeration device 100 for immunohistochemistry equipment.

[0035] See also Figures 1 to 9, this embodiment discloses a reagent refrigeration device 100 for immunohistochemistry equipment, which includes: a mounting plate 1, a placement table 2 connected to the mounting plate 1, and a refrigeration component 32 connected to the placement table 2;

[0036] The placement table 2 is used to store the reagent box (not shown in the figure), and the refrigeration component 32 is used to deliver cold energy to the reagent box to achieve refrigeration of the reagent contained in the reagent box;

[0037] The placement platform 2 includes a plate body 20, which is provided with a guide groove 22 for guiding condensate, a baffle plate 21 disposed at one end of the guide groove 22, and a confluence groove 23 disposed at the other end of the guide groove 22. The confluence groove 23 has a drainage hole 24 at its bottom. In this embodiment, the plate body 20 is a rectangular plate. The guide groove 22 extends along its length, with its short sides adjacent to the baffle plate 21 and confluence groove 23, respectively.

[0038] The reagent refrigeration device 100 of the immunohistochemistry apparatus of this embodiment is used as follows Figure 1 and Figure 2 Similarly, the reagent refrigeration device 100 of the immunohistochemistry apparatus is assembled on the immunohistochemistry apparatus during use. The placement table 2 is horizontal, and the reagent kits containing various reagents are placed thereon. In this embodiment, the reagent kits are placed on the placement table 2 in a drawer-like manner. The mounting plate 1 is provided with a drawer compartment, and the placement table 2 is disposed at the bottom of the drawer compartment.

[0039] Please refer again Figure 3 The guide grooves 22 are several parallel linear grooves recessed into the top surface of the placement platform 2. The ends of these linear grooves extend to the baffle plate 21 and the confluence groove 23, respectively. When the reagent kit is placed on the placement platform 2 and condensation is generated during refrigeration, it flows into the confluence groove 23 and is discharged through the drain hole 24. The baffle plate 21 is a raised baffle portion on the top surface of the placement platform 2. It is used to prevent condensation from flowing out of one side of the baffle plate 21, allowing it to flow along the guide grooves 22 to the confluence groove 23.

[0040] Please refer again Figure 7 The bottom of the confluence groove 23 is lower than the bottom of the guide groove 22, so that the condensate collected in the guide groove 22 flows to the confluence groove 23 under the action of its own gravity.

[0041] In this embodiment, the baffle 21 is a stepped baffle with a vertical protrusion height of 3-6 mm. That is, the height of the top of the baffle 21 relative to the bottom wall of the guide channel 22 of the placement table 2 is 3-6 mm. This height design can effectively block condensation while not affecting the removal of the reagent cartridge.

[0042] In this embodiment, if Figure 9 As shown, the bottom of the confluence groove 23 is 0.5-1.2 mm lower than the bottom of the guide groove 22 .

[0043] like Figure 3 As shown, the drainage hole 24 is a circular through hole with a diameter of 2-3 mm. As needed, the number of the drainage holes 24 can be two or more, and the drainage holes 24 are opened on the bottom wall of the confluence trough 23 or the side wall near the bottom wall. The size of the drainage holes 24 can be set according to actual needs.

[0044] Please refer again Figure 5 The placement table 2 is further provided with a temperature detection sensor 6 , which is used to detect the temperature of the reagent box in real time to control the cooling power of the cooling component 32 .

[0045] The placement table 2 is provided with a detection sensor for detecting the presence of a reagent kit, and the refrigeration assembly 32 is configured to activate or deactivate refrigeration based on a signal from the detection sensor. In this embodiment, the detection sensor is a detection circuit board 5 connected to the mounting plate 1 and provided with a detection circuit and a sensor, such as an infrared or photoelectric sensor. When a reagent kit is placed on the placement table 2, the detection circuit board 5 detects a signal indicating the presence of the reagent kit and controls the refrigeration assembly 32 to activate refrigeration based on the detection signal. Otherwise, the refrigeration assembly 32 is controlled to deactivate refrigeration, thereby avoiding energy waste and reducing energy consumption.

[0046] It is understood that in this embodiment, the temperature detection sensor 6 and the detection circuit board 5 can be independent detection units, or a combination of a sensor and a device controller. The temperature detection sensor 6 and the detection circuit board 5 can be designed to have only a detection signal function, and the detection signal is received and processed by the device controller, and a control signal is output according to the control strategy. The device processor refers to the controller of the immunohistochemistry device. Of course, the temperature detection sensor 6 and the detection circuit board 5 can also be independent control modules with signal detection, data processing, and instruction issuance functions, which independently implement signal detection and output control instructions to the refrigeration component 32 to provide decision information for the refrigeration component 32.

[0047] Please refer again Figures 1 to 5The mounting plate 1 is further provided with a collection box 4, which is connected to the drainage hole 24 and is used to collect condensate. The collection box 4 includes a container box 41, a straight discharge pipe 42 and an overflow pipe 43 connected to the container box 41, and the overflow pipe 43 is vertically higher than the straight discharge pipe 42. The condensate collected in the container box 41 is directly discharged out of the equipment through the straight discharge pipe 42. The discharge of condensate from the straight discharge pipe 42 is irregular. During normal operation of the equipment, the condensate is temporarily stored in the container box 41. If the container box 41 is full, it will be automatically discharged through the overflow pipe 43 to prevent the overflow of condensate from affecting the equipment or the detection process.

[0048] To improve the cooling effect, the reagent refrigeration device 100 of the immunohistochemistry apparatus further includes an air supply assembly 31 connected to a refrigeration assembly 32. The refrigeration assembly 32 includes a semiconductor cooling fin 321 and a heat sink 322. The semiconductor cooling fin 321 abuts the bottom of the placement table 2, and the heat sink 322 abuts the semiconductor cooling fin 321. The air supply assembly 32 is used to supply air to the heat sink 322 to improve heat dissipation efficiency. In this embodiment, the heat sink 322 is disposed at the bottom of the semiconductor cooling fin 321.

[0049] The air supply assembly 31 includes a fan 311, an air duct plate 312 connected to the fan 311, and a heat dissipation pipe 313 connected to the air duct plate 312. The fan 311, the air duct plate 312, and the heat dissipation pipe 313 form a connected air duct, which passes through the heat sink 322 to quickly remove heat generated by the heat sink 322. The air duct plate 312 is a ventilation hood that covers the heat sink 322, and the heat sink 322 is fixedly connected to the bottom of the mounting plate 1 via a bracket.

[0050] The refrigeration assembly 32 and the air supply assembly 31 form a refrigeration module 3 of this embodiment, and the refrigeration module 3 can be used as an independent refrigeration unit.

[0051] Among them, the semiconductor cooling plate 321 is a heat transfer tool. When current flows through a thermocouple pair formed by connecting an N-type semiconductor material and a P-type semiconductor material, heat transfer occurs between the two ends, and heat is transferred from one end to the other, resulting in a temperature difference between the hot and cold ends. However, the semiconductor itself has resistance, and when current passes through the semiconductor, it generates heat, which affects heat transfer. In addition, heat between the two plates is also transferred in the opposite direction through the air and the semiconductor material itself. When the temperature difference between the hot and cold ends reaches a certain level, the amount of heat transfer is equal, and an equilibrium point is reached, where the positive and negative heat transfer cancel each other out. At this point, the temperature of the hot and cold ends will not change further. To achieve a lower temperature, the temperature of the hot end can be reduced by heat dissipation or other methods.

[0052] The reagent refrigeration device of the immunohistochemistry equipment of this embodiment has added a condensate collection and discharge structure, which can effectively handle the condensate generated during the refrigeration process; a new reagent kit detection function has been added, and the refrigeration module can automatically turn on or off the refrigeration function according to the presence or absence of a reagent kit, effectively reducing the energy consumption of the equipment; a new temperature detection function has been added to detect the space temperature in real time and automatically adjust the refrigeration chip power through temperature feedback.

[0053] The above examples are merely provided to further illustrate the technical content of the present invention for easier understanding by the reader, but do not limit the embodiments of the present invention to these examples. Any extension or re-creation of the technology based on the present invention is protected by the present invention. The scope of protection of the present invention shall be determined by the claims.

Claims

1. A reagent refrigeration device for immunohistochemistry equipment, characterized in that: include: A mounting plate, a placement table connected to the mounting plate, and a refrigeration assembly connected to the placement table; The placement table is used to store the reagent kit, and the refrigeration component is used to deliver cold energy to the reagent kit to achieve refrigeration of the reagent contained in the reagent kit; The placement table includes a guide groove for guiding condensate, a baffle arranged at one end of the guide groove, and a confluence groove arranged at the other end of the guide groove; a drainage hole is provided at the bottom of the confluence groove.

2. The reagent refrigeration device for immunohistochemistry equipment according to claim 1, characterized in that: The guide grooves are a plurality of parallel linear grooves recessed on the top surface of the placement table, and two ends of the linear grooves extend to the baffle plate and the confluence groove respectively.

3. The reagent refrigeration device for immunohistochemistry equipment according to claim 2, characterized in that: The bottom of the confluence groove is lower than the bottom of the guide groove.

4. The reagent refrigeration device for immunohistochemistry equipment according to claim 2, characterized in that: The baffle is a stepped baffle, and the vertical protrusion height of the stepped baffle is 3-6 mm.

5. The reagent refrigeration device for immunohistochemistry equipment according to claim 4, characterized in that: The bottom of the confluence groove is 0.5-1.2 mm lower than the bottom of the guide groove.

6. The reagent refrigeration device for immunohistochemistry equipment according to claim 2, characterized in that: The drainage hole is a circular through hole with a diameter of 2-3 mm.

7. The reagent refrigeration device for immunohistochemistry equipment according to any one of claims 1 to 6, characterized in that: The placement table is further provided with a temperature detection sensor, which is used to detect the temperature of the reagent box in real time to control the refrigeration power of the refrigeration component.

8. The reagent refrigeration device for immunohistochemistry equipment according to claim 7, characterized in that: The placement table is provided with a detection sensor for detecting whether a reagent kit exists, and the refrigeration component is used to start or stop refrigeration according to a signal from the detection sensor.

9. The reagent refrigeration device for immunohistochemistry equipment according to claim 8, characterized in that: The mounting plate is further provided with a collecting box, which is connected to the drainage hole and is used to collect condensate. The collecting box is also provided with a straight discharge pipe and an overflow pipe, and the vertical height of the overflow pipe is higher than that of the straight discharge pipe.

10. The reagent refrigeration device for immunohistochemistry equipment according to claim 7, characterized in that: The reagent refrigeration device of the immunohistochemistry equipment also includes an air supply component, which includes a semiconductor refrigeration fin and a heat sink. The semiconductor refrigeration fin is abutted against the bottom of the placement table, and the heat sink is abutted against the semiconductor refrigeration fin. The air supply component is used to supply air to the heat sink.

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