An intelligent thrombus aspiration system with adaptive dynamic adjustment

Abstract

The present application relates to the field of medical device technology, and provides an adaptive and dynamically adjustable intelligent thrombus aspiration system that can perform relatively accurate aspiration gear switching judgments to ensure the stability of the intelligent thrombus aspiration system. The intelligent thrombus aspiration system includes a processing device, an aspiration catheter, a negative pressure suction pump, a first pressure sensor, and a second pressure sensor; the processing device controls the intermittent opening and closing of the aspiration catheter according to the opening and closing times corresponding to the current aspiration gear; the processing device obtains a blockage coefficient based on the proximal pressure value collected by the first pressure sensor when the aspiration catheter is opened and the distal pressure value collected by the second pressure sensor when the aspiration catheter is opened; the processing device determines the preset blockage coefficient range corresponding to each aspiration gear, so as to obtain a suction gear lifting and lowering strategy.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to an adaptive and dynamically adjustable intelligent thrombus aspiration system, processing equipment, storage medium, and computer program product. Background Art

[0002] Thrombus aspiration technology is an interventional treatment technology for clearing blood clots in blood vessels. This technology mainly uses specific instruments to extract blood clots from blood vessels to restore blood vessel patency. The system that implements this technology can be called an intelligent thrombus aspiration system.

[0003] When the intelligent thrombus aspiration system is in operation, it can switch between different aspiration gears; the accuracy of the judgment of switching the aspiration gears will affect the stability of the operation of the intelligent thrombus aspiration system. Summary of the Invention

[0004] Based on this, it is necessary to provide an intelligent thrombus aspiration system, processing equipment, storage medium and computer program product to address the above technical problems.

[0005] The present application provides an adaptive and dynamically adjustable intelligent thrombus aspiration system, comprising: a processing device, an aspiration catheter, a negative pressure suction pump, a first pressure sensor, and a second pressure sensor, wherein the first pressure sensor is used to monitor the pressure on an end of the aspiration catheter close to the negative pressure suction pump, and the second pressure sensor is used to monitor the pressure on an end of the aspiration catheter away from the negative pressure suction pump;

[0006] The processing device performs the following steps:

[0007] Controlling the suction conduit to be intermittently opened and closed according to the opening duration and closing duration corresponding to the current suction gear;

[0008] Obtaining a blockage coefficient based on a proximal pressure value acquired by the first pressure sensor when the aspiration catheter is opened and a distal pressure value acquired by the second pressure sensor when the aspiration catheter is opened;

[0009] In the preset blockage coefficient range corresponding to each suction gear, the preset blockage coefficient range in which the blockage coefficient is located is determined to obtain a suction gear raising / lowering strategy.

[0010] In one embodiment, the obstruction coefficient is obtained based on the proximal pressure value collected by the first pressure sensor when the aspiration catheter is opened and the distal pressure value collected by the second pressure sensor when the aspiration catheter is opened, including:

[0011] Obtaining a proximal pressure value at a final sampling moment and an average proximal pressure value based on several proximal pressure values ​​collected by the first pressure sensor when the suction catheter is opened;

[0012] Obtaining a proximal pressure-related value based on the product of the proximal pressure average value and the confidence value;

[0013] Obtaining a target proximal pressure value based on a relative magnitude between the proximal pressure-related value and the proximal pressure value at the last sampling moment;

[0014] Obtaining a distal pressure value at a final sampling moment and an average distal pressure value based on several distal pressure values ​​collected by the second pressure sensor when the suction catheter is opened;

[0015] Obtaining a distal pressure-related value based on a product of the distal pressure average value and the confidence value;

[0016] Obtaining a target distal pressure value based on a relative magnitude between the distal pressure-related value and the distal pressure value at the last sampling moment;

[0017] The obstruction coefficient is obtained according to the ratio between the target proximal pressure value and the target distal pressure value.

[0018] In one embodiment, within the preset blockage coefficient range corresponding to each suction gear, determining the preset blockage coefficient range in which the blockage coefficient is located to obtain a suction gear raising / lowering strategy includes:

[0019] Determining the preset blockage coefficient range in which the blockage coefficient is located within the preset blockage coefficient range corresponding to each suction gear;

[0020] Obtaining a target suction gear according to the suction gear corresponding to the preset blockage coefficient range in which the blockage coefficient is located;

[0021] If the target suction gear is higher than the current suction gear, a suction gear raising / lowering strategy is obtained based on an adjustment method for raising the suction gear from the current suction gear to the target suction gear;

[0022] If the target suction gear is lower than the current suction gear, a hysteresis lower limit value is obtained according to the difference between the lower limit value of the preset blockage coefficient range corresponding to the current suction gear and the target hysteresis value. Based on the relative size between the hysteresis lower limit value and the blockage coefficient, it is determined whether to use an adjustment method based on lowering the current suction gear to the target suction gear to obtain a suction gear raising / lowering strategy.

[0023] In one embodiment, determining whether to adjust the suction gear from the current suction gear to the target suction gear based on the relative size between the hysteresis lower limit value and the blockage coefficient to obtain the suction gear raising / lowering strategy includes:

[0024] If the blocking coefficient is greater than or equal to the hysteresis lower limit, a suction gear raising / lowering strategy is obtained by maintaining the current suction gear;

[0025] If the blocking coefficient is less than the hysteresis lower limit, a suction gear raising / lowering strategy is obtained based on an adjustment method of lowering the current suction gear to the target suction gear.

[0026] In one embodiment, determining a target hysteresis value includes:

[0027] obtaining a target downshift scenario according to the current suction gear and the target suction gear;

[0028] Among the hysteresis values ​​corresponding to the various downshift scenarios, a hysteresis value corresponding to the target downshift scenario is determined to obtain a target hysteresis value.

[0029] In one embodiment, determining the hysteresis value corresponding to each downshift scenario includes:

[0030] Acquire a set of blocking coefficient drop test events that matches a downshift scenario to be calibrated; the downshift scenario to be calibrated is any downshift scenario;

[0031] Determining a disturbance test event set in which the pumped material does not change within the blockage coefficient drop test event set;

[0032] Determining a target value; wherein the blocking coefficients corresponding to at least a preset proportion of the disturbance test events in the disturbance test event set are not lower than a hysteresis lower limit value corresponding to the target value; and the hysteresis lower limit value corresponding to the target value is a difference between a lower limit value of a preset blocking coefficient range corresponding to the high suction gear of the downshift scenario to be calibrated and the target value;

[0033] A hysteresis value corresponding to the downshift scenario to be calibrated is obtained according to the target value.

[0034] In one embodiment, controlling the opening of the suction catheter comprises:

[0035] First, the voltage required to open the suction duct is applied to the solenoid valve of the suction duct according to a first duty cycle, and then the voltage required to open the suction duct is applied to the solenoid valve of the suction duct according to a second duty cycle, so that the suction duct is opened; the first duty cycle is higher than the second duty cycle.

[0036] In one embodiment, the intelligent thrombus aspiration system has multiple aspiration gears; the higher the aspiration gear, the longer the aspiration catheter is open, and the greater the negative pressure suction force provided by the negative pressure suction pump;

[0037] The intelligent thrombus aspiration system further includes a saline pipeline. When the intelligent thrombus aspiration system is in a high aspiration gear, the aspiration catheter and the saline pipeline are alternately opened and closed.

[0038] The present application provides a processing device, including a memory and a processor, wherein the memory stores a computer program, and the processor implements the steps performed by the processing device when executing the computer program; the processing device belongs to the device in the adaptive dynamically adjusted intelligent thrombus aspiration system described in any of the above embodiments.

[0039] The present application provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the steps executed by a processing device; the processing device belongs to the device in the adaptive dynamically adjusted intelligent thrombus aspiration system described in any of the above embodiments.

[0040] The present application provides a computer program product having a computer program stored thereon, which implements the steps executed by a processing device when the computer program is executed by a processor; the processing device belongs to the device in the adaptive dynamically adjusted intelligent thrombus aspiration system described in any of the above embodiments.

[0041] The intelligent thrombus aspiration system provided in the present application includes a processing device, a suction catheter, a negative pressure suction pump, a first pressure sensor and a second pressure sensor, the first pressure sensor is used to monitor the pressure on the suction catheter close to the negative pressure suction pump, and the second pressure sensor is used to monitor the pressure on the suction catheter away from the negative pressure suction pump; the processing device controls the intermittent opening and closing of the suction catheter according to the opening time and closing time corresponding to the current suction gear; the processing device obtains the blockage coefficient based on the proximal pressure value collected by the first pressure sensor when the suction catheter is opened and the distal pressure value collected by the second pressure sensor when the suction catheter is opened, and the current state of the intelligent thrombus aspiration system is reflected through the blockage coefficient; the processing device can determine the preset blockage coefficient range corresponding to each suction gear, obtain the suction gear lifting and lowering strategy, and form a more accurate suction gear switching judgment result to ensure the operation stability of the intelligent thrombus aspiration system as much as possible. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] In order to more clearly illustrate the technical solutions in the embodiments of the present application or related technologies, the following briefly introduces the drawings required for use in the embodiments or related technical descriptions. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0043] Figure 1is a schematic structural diagram of an intelligent thrombus aspiration system in one embodiment;

[0044] Figure 2 is another structural schematic diagram of an intelligent thrombus aspiration system in one embodiment;

[0045] Figure 3 A schematic diagram of steps executed by a processing device in one embodiment;

[0046] Figure 4 A schematic structural diagram of an attraction connector in one embodiment;

[0047] Figure 5 A schematic structural diagram of a vacuum converter in one embodiment;

[0048] Figure 6 A schematic diagram of pressure changes at the tip of the suction catheter in intermittent mode in one embodiment;

[0049] Figure 7 A schematic diagram of pressure changes at the tip of the suction catheter in an oscillating mode in one embodiment;

[0050] Figure 8 A schematic diagram of the software architecture and the interaction between software components in one embodiment;

[0051] Figure 9 is a main program flow chart in one embodiment;

[0052] Figure 10 A flow chart for determining a suction gear in one embodiment;

[0053] Figure 11 A flowchart of controlling corresponding indicator lights to light up in one embodiment;

[0054] Figure 12 The figure is a flowchart of a process in which a microprocessor serial port receives parameter data in one embodiment. DETAILED DESCRIPTION

[0055] In order to make the purpose, technical solutions and advantages of this application more clear, the following further describes this application in detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application.

[0056] The present application provides an intelligent thrombus aspiration system with adaptive dynamic adjustment, which can automatically adjust the aspiration gear according to the actual aspiration situation. The intelligent thrombus aspiration system may include Figure 1The components shown include a treatment device, an aspiration catheter, a vacuum pump, a first pressure sensor, and a second pressure sensor. The first pressure sensor is used to monitor the pressure at the end of the aspiration catheter near the vacuum pump, and the second pressure sensor is used to monitor the pressure at the end of the aspiration catheter away from the vacuum pump. The intelligent thrombus aspiration system may also include a flow sensor for monitoring the flow rate in the aspiration catheter.

[0057] The negative pressure suction pump can include a vacuum pump, a pressure regulating valve, a negative pressure gauge and a disposable collection bottle. The vacuum pump generates negative pressure attraction, and then adjusts the negative pressure attraction to the target pressure through the pressure regulating valve. The pointer of the negative pressure gauge displays the current negative pressure value. It is connected to the disposable collection bottle through a pipe, and then connected to the disposable suction connecting tube and the suction catheter, thereby achieving the suction of blood clots in the blood vessels.

[0058] The intelligent thrombus aspiration system can have multiple aspiration levels. The higher the aspiration level, the longer the aspiration catheter remains open, and the greater the negative pressure suction provided by the negative pressure suction pump. This aspiration level setting allows the intelligent thrombus aspiration system to reduce the duration of the aspiration catheter's opening when aspirating blood, thereby reducing the amount of blood aspirated and reducing blood loss. This setting can also increase the duration of the aspiration catheter's opening when a thrombus is aspirated, allowing the thrombus to be aspirated through a greater negative pressure suction.

[0059] The intelligent thrombus aspiration system may further include a saline pipeline, which is a circulation pipeline for physiological saline. The high suction gear among the multiple suction gears may be set as follows: the suction catheter and the saline pipeline may be opened and closed alternately; that is, when the intelligent thrombus aspiration system is in the high suction gear, the suction catheter and the saline pipeline may be opened and closed alternately. The high suction gear may be determined by sorting the multiple suction gears from low to high, and the suction gears in the last N positions are the high suction gears; N is a positive integer greater than or equal to 1. The high suction gear may also be determined by sorting the multiple suction gears from high to low, and the suction gears in the first M positions are the high suction gears; M is a positive integer greater than or equal to 1.

[0060] The above setting of the high suction gear enables the intelligent thrombus aspiration system to use a pulse cycle suction method when a thrombus is aspirated or the aspiration catheter is blocked by a thrombus, so that the thrombus itself or the part attached to the blood vessel wall fatigues, and then the thrombus can be successfully extracted.

[0061] Figure 2This is another structural diagram of the intelligent thrombus aspiration system, wherein 201 is a vacuum pump, 202 is a power port, 203 is a power cord, 204 is a suction connector, 205 is a disposable collection bottle, 206 is a disposable suction connecting tube, 207 is normal saline, 208 is a saline pipeline, 209 is a vacuum converter, 210 is a suction catheter connecting tube, and 211 is a suction catheter.

[0062] When in use, slowly insert the suction connector into the upper cover boss of the disposable collection bottle of the negative pressure suction pump, insert the power cord into the power port of the negative pressure suction pump, connect the Luer connector on the suction catheter connecting tube to the suction catheter and tighten it, connect the bottle needle of the saline pipeline to the physiological saline and tighten it. After the installation is completed, a passage is formed between the negative pressure suction pump, the disposable suction connecting tube and the suction catheter.

[0063] The vacuum converter can be used to convert the air pressure state in the suction catheter, for example, the air pressure state in the suction catheter can be converted between positive pressure and negative pressure. The suction catheter is provided with a suction port, through which blood clots in the blood vessel can be suctioned out.

[0064] The processing device can perform Figure 3 The steps shown are used to determine whether to switch the suction gear.

[0065] Step S301 , controlling the suction catheter to be intermittently opened and closed according to the opening duration and closing duration corresponding to the current suction gear.

[0066] There are five aspiration gears: the first, second, third, fourth, and fifth aspiration gears, from lowest to highest. The higher the aspiration gear, the longer the aspiration catheter remains open, and the greater the negative pressure suction provided by the vacuum pump. The fourth and fifth aspiration gears can be considered high aspiration gears. In these gears, the intelligent thrombus aspiration system alternately opens and closes the aspiration catheter and saline line.

[0067] Each suction gear has its own corresponding opening time and closing time.

[0068] Taking the third suction gear as an example, the opening time corresponding to the third suction gear is Δt_on_3, and the closing time is Δt_off_3. The solenoid valve of the suction duct can be controlled to open and the opening time is Δt_on_3. Accordingly, the suction duct is in the open state and the opening time is Δt_on_3; when the opening time of the solenoid valve of the suction duct is Δt_on_3, the solenoid valve of the suction duct is controlled to close and the closing time is Δt_off_3. Accordingly, the suction duct is in the closed state and the closing time is Δt_on_3; when the closing time of the solenoid valve of the suction duct is Δt_off_3, the solenoid valve of the suction duct is controlled to open and the opening time is Δt_on_3. Accordingly, the suction duct is in the open state and the opening time is Δt_on_3. Therefore, the suction duct is intermittently opened and closed, and the opening duration of the suction duct matches the opening duration corresponding to the third suction gear, and the closing duration of the suction duct matches the closing duration corresponding to the third suction gear.

[0069] Among them, one opening and one closing can be regarded as one cycle.

[0070] Step S302 : Obtaining a blockage coefficient based on the proximal pressure value collected by the first pressure sensor when the suction catheter is opened and the distal pressure value collected by the second pressure sensor when the suction catheter is opened.

[0071] For example, if the current suction gear is the third suction gear, the suction catheter is opened at time t0 during a certain cycle. The suction catheter is then opened for a period of time t0 + Δt_on_3 during that cycle. The first pressure sensor can acquire pressure values ​​during the opening period t0 + Δt_on_3, which are referred to as proximal pressure values. The second pressure sensor can acquire pressure values ​​during the opening period t0 + Δt_on_3, which are referred to as distal pressure values.

[0072] According to the proximal pressure value and the distal pressure value, an obstruction coefficient (which can be denoted as R) can be obtained. The obstruction coefficient reflects the obstruction state of the intelligent thrombus aspiration system during the opening period t0+Δt_on_3.

[0073] Step S303 : determining the preset blocking coefficient range in which the blocking coefficient is located in the preset blocking coefficient range corresponding to each suction gear, so as to obtain a suction gear raising / lowering strategy.

[0074] The preset blockage coefficient range corresponding to each suction gear can be pre-set. Taking the five suction gears as an example, the preset blockage coefficient range corresponding to the first suction gear can be recorded as [R' A ,R' B ], the preset blockage coefficient range corresponding to the second suction gear can be recorded as [R' B ,R'C ], the preset blockage coefficient range corresponding to the third suction gear can be recorded as [R' C ,R' D ], the preset blockage coefficient range corresponding to the fourth suction gear can be recorded as [R' D ,R' E ], the preset blockage coefficient range corresponding to the fifth suction gear can be recorded as [R' E ,R' F ].

[0075] The processing device can determine which suction gear the blocking coefficient R falls within, and determine the suction gear corresponding to the preset blocking coefficient range in which the blocking coefficient R is located. This suction gear is called the target suction gear, and a suction gear lifting strategy is formed based on the relative height between the target suction gear and the current suction gear.

[0076] The intelligent thrombus aspiration system provided in the above embodiment includes a processing device, a suction catheter, a negative pressure suction pump, a first pressure sensor and a second pressure sensor. The first pressure sensor is used to monitor the pressure on the suction catheter close to the negative pressure suction pump, and the second pressure sensor is used to monitor the pressure on the suction catheter away from the negative pressure suction pump. The processing device controls the intermittent opening and closing of the suction catheter according to the opening time and closing time corresponding to the current suction gear. The processing device obtains the blockage coefficient based on the proximal pressure value collected by the first pressure sensor when the suction catheter is opened and the distal pressure value collected by the second pressure sensor when the suction catheter is opened, and the current state of the intelligent thrombus aspiration system is reflected through the blockage coefficient. The processing device can determine the preset blockage coefficient range corresponding to each suction gear, obtain the suction gear lifting and lowering strategy, and form a more accurate suction gear switching judgment result to ensure the operation stability of the intelligent thrombus aspiration system as much as possible.

[0077] In one embodiment, the obstruction coefficient is obtained based on the proximal pressure value collected by the first pressure sensor when the aspiration catheter is opened and the distal pressure value collected by the second pressure sensor when the aspiration catheter is opened, including:

[0078] According to several proximal pressure values ​​collected by the first pressure sensor when the suction catheter is opened, the proximal pressure value at the last sampling moment and the proximal pressure average value are obtained; based on the product of the proximal pressure average value and the confidence value, the proximal pressure correlation value is obtained; based on the relative size between the proximal pressure correlation value and the proximal pressure value at the last sampling moment, the target proximal pressure value is obtained; according to several distal pressure values ​​collected by the second pressure sensor when the suction catheter is opened, the distal pressure value at the last sampling moment and the distal pressure average value are obtained; based on the product of the distal pressure average value and the confidence value, the distal pressure correlation value is obtained; based on the relative size between the distal pressure correlation value and the distal pressure value at the last sampling moment, the target distal pressure value is obtained; and according to the ratio between the target proximal pressure value and the target distal pressure value, the blockage coefficient is obtained.

[0079] Taking the third suction gear as an example, the opening time of the suction catheter in a certain cycle is recorded as time t0, and the opening period of the suction catheter in the cycle is t0+Δt_on_3.

[0080] The first pressure sensor collects several proximal pressure values ​​at a set frequency during the on-time period t0 + Δt_on_3. Because each proximal pressure value has a corresponding sampling time, the processing device can determine the proximal pressure value at the last sampling time among these proximal pressure values. The processing device can also average the several proximal pressure values ​​collected by the first pressure sensor during the on-time period t0 + Δt_on_3 to obtain an average proximal pressure value.

[0081] The processing device multiplies the proximal pressure average value by the confidence value, and the resulting product is used as the proximal pressure-related value. Based on the relative magnitude of the proximal pressure-related value and the proximal pressure value at the last sampling moment, the processing device may determine a target proximal pressure value between the proximal pressure-related value and the proximal pressure value at the last sampling moment. Specifically, the processing device may use the maximum value of the proximal pressure-related value and the proximal pressure value at the last sampling moment as the target proximal pressure value, thereby describing the maximum negative pressure capability that the intelligent thrombus aspiration system can provide during that cycle.

[0082] The second pressure sensor collects several remote pressure values ​​at a set frequency during the on-time period t0 + Δt_on_3. Because each remote pressure value has a corresponding sampling time, the processing device can determine the remote pressure value at the last sampling time among these remote pressure values. The processing device can also average the multiple remote pressure values ​​collected by the second pressure sensor during the on-time period t0 + Δt_on_3 to obtain an average remote pressure value.

[0083] The processing device multiplies the distal pressure average value by the confidence value, and the resulting product is used as the distal pressure-related value. The processing device may determine a target distal pressure value between the distal pressure-related value and the distal pressure value at the last sampling time based on the relative magnitude between the distal pressure-related value and the distal pressure value at the last sampling time.

[0084] Considering that the distal end is far away from the negative pressure suction pump, there will be a certain delay in the negative pressure attraction from the negative pressure suction pump to the distal end. Therefore, the processing device can use the minimum value of the distal pressure-related value and the distal pressure value at the last sampling moment as the target distal pressure value, thereby describing the negative pressure value at the distal end actually acted on by the intelligent thrombus aspiration system during this cycle.

[0085] The processing device can obtain the ratio between the target proximal pressure value and the target distal pressure value, and obtain the blockage coefficient based on the ratio, so as to more accurately reflect the blockage state of the intelligent thrombus aspiration system in the cycle.

[0086] In one embodiment, within the preset blockage coefficient range corresponding to each suction gear, determining the preset blockage coefficient range in which the blockage coefficient is located to obtain a suction gear raising / lowering strategy includes:

[0087] In the preset blockage coefficient range corresponding to each suction gear, the preset blockage coefficient range in which the blockage coefficient is located is determined; according to the suction gear corresponding to the preset blockage coefficient range in which the blockage coefficient is located, the target suction gear is obtained; if the target suction gear is higher than the current suction gear, the suction gear lifting strategy is obtained based on the adjustment method of raising the current suction gear to the target suction gear; if the target suction gear is lower than the current suction gear, the hysteresis lower limit value is obtained according to the difference between the lower limit value of the preset blockage coefficient range corresponding to the current suction gear and the target hysteresis value, and based on the relative size between the hysteresis lower limit value and the blockage coefficient, it is determined whether to obtain the suction gear lifting strategy based on the adjustment method of lowering the current suction gear to the target suction gear.

[0088] Taking the third suction gear as an example, the opening time of the suction catheter in a certain cycle is recorded as time t0, and the opening period of the suction catheter in the cycle is t0+Δt_on_3.

[0089] After obtaining the blockage coefficient R based on the proximal pressure value collected by the first pressure sensor in the on-time period t0+Δt_on_3 and the distal pressure value collected by the second pressure sensor in the on-time period t0+Δt_on_3, the processing device can determine which suction gear the blockage coefficient R falls into.

[0090] If the blocking coefficient R falls within [R' C ,R' D ], [R' C,R' D ]The corresponding suction gear is the third suction gear, that is, the target suction gear is the third suction gear, which is consistent with the current suction gear. Then, the suction gear lifting strategy can be obtained by maintaining the current suction gear adjustment method, that is, the obtained suction gear lifting strategy represents maintaining the current suction gear without lifting or lowering adjustment; subsequently, the processing equipment can continue to perform relevant control according to the third suction gear.

[0091] If the blocking coefficient R falls within [R' D ,R' E ], [R' D ,R' E ]The corresponding suction gear is the fourth suction gear, that is, the target suction gear is the fourth suction gear, and the target suction gear is higher than the current suction gear. Then, the suction gear lifting strategy can be generated by adjusting the gear from the third suction gear to the fourth suction gear, that is, the obtained suction gear lifting strategy represents that the suction gear is raised to the fourth suction gear; subsequently, the processing equipment can perform relevant control according to the fourth suction gear.

[0092] If the blocking coefficient R falls within [R' B ,R' C ], [R' B ,R' C ]The corresponding suction gear is the second suction gear, that is, the target suction gear is the second suction gear, and the target suction gear is lower than the current suction gear.

[0093] Considering that the "water hammer" effect generated by the electromagnetic valve of the suction catheter when opening and closing will affect the judgment of the suction gear downgrade. The suction material at the suction port of the suction catheter contains a small amount of thrombus, sometimes the blockage coefficient R calculated by the first pressure sensor and the second pressure sensor falls to [R' B ,R' C ] Although the blocking coefficient drops, the pumped substance does not actually change. It is the objective disturbance that causes the state change.

[0094] Therefore, when the target suction gear is lower than the current suction gear, it can be further determined whether the gear is actually downshifted. Taking the current suction gear as the third suction gear as an example, the processing device can specifically calculate the lower limit value R' of the preset blockage coefficient range corresponding to the third suction gear. C The difference between the target hysteresis value L_target and the lower hysteresis limit (ie R' C -L_target), based on the lower hysteresis limit (R' C The relative size between the suction gear L_target) and the blocking coefficient R is used to determine whether to downshift from the current suction gear to the target suction gear, so as to obtain a suction gear up / down shift strategy, thereby avoiding erroneous downshifting caused by objective disturbances.

[0095] In one embodiment, based on the relative size between the hysteresis lower limit value and the blockage coefficient, determining whether to adjust the suction gear from the current suction gear to the target suction gear to obtain the suction gear raising / lowering strategy includes:

[0096] If the blockage coefficient is greater than or equal to the hysteresis lower limit, the suction gear lifting strategy is obtained by adjusting the current suction gear to maintain the current suction gear; if the blockage coefficient is less than the hysteresis lower limit, the suction gear lifting strategy is obtained based on the adjustment method of lowering the current suction gear to the target suction gear.

[0097] If the blocking coefficient R is greater than or equal to the hysteresis lower limit (R' C -L_target), in order to maintain the adjustment mode of the current suction gear, the suction gear lifting strategy is obtained, that is, the obtained suction gear lifting strategy indicates that the current suction gear is maintained without lifting or lowering adjustment; subsequently, the processing equipment can continue to perform relevant control according to the third suction gear.

[0098] If the blocking coefficient R is less than the hysteresis lower limit value, the suction gear lifting strategy is obtained based on the adjustment method of lowering the current suction gear to the target suction gear, that is, the obtained suction gear lifting strategy represents that the suction gear is lowered to the second suction gear; subsequently, the processing equipment can perform relevant control according to the second suction gear.

[0099] In one embodiment, determining a target hysteresis value includes:

[0100] A target downshift scenario is obtained according to the current suction gear and the target suction gear; and a hysteresis value corresponding to the target downshift scenario is determined among the hysteresis values ​​corresponding to the various downshift scenarios to obtain a target hysteresis value.

[0101] Taking the five aforementioned suction gears as an example, downshifting from the second suction gear to the first suction gear can be considered a downshift scenario, which can be recorded as Downgrade_2_1; downshifting from the third suction gear to the second suction gear can be considered a downshift scenario, which can be recorded as Downgrade_3_2; downshifting from the third suction gear to the first suction gear can be considered a downshift scenario, which can be recorded as Downgrade_3_1; downshifting from the fourth suction gear to the third suction gear can be considered a downshift scenario, which can be recorded as Downgrade_4_3; downshifting from the fourth suction gear to the second suction gear can be considered a downshift scenario, which can be recorded as Downgrade_4_2; Downshifting from the fourth suction gear to the first suction gear can be regarded as a downshift scenario, which can be recorded as Downgrade_4_1; downshifting from the fifth suction gear to the fourth suction gear can be regarded as a downshift scenario, which can be recorded as Downgrade_5_4; downshifting from the fifth suction gear to the third suction gear can be regarded as a downshift scenario, which can be recorded as Downgrade_5_3; downshifting from the fifth suction gear to the second suction gear can be regarded as a downshift scenario, which can be recorded as Downgrade_5_2; downshifting from the fifth suction gear to the first suction gear can be regarded as a downshift scenario, which can be recorded as Downgrade_5_1.

[0102] Each of the aforementioned downshift scenarios has a corresponding hysteresis value. For example, downshift scenario Downgrade_2_1 has a corresponding hysteresis value, which can be recorded as L_2_1; downshift scenario Downgrade_3_2 has a corresponding hysteresis value, which can be recorded as L_3_2.

[0103] If the current suction gear is the third suction gear and the target suction gear is the second suction gear, the target downshift scenario may be determined to be Downgrade_3_2; the processing device may determine the hysteresis value L_3_2 corresponding to the downshift scenario Downgrade_3_2 as the target hysteresis value L_target.

[0104] In one embodiment, determining the hysteresis value corresponding to each downshift scenario includes:

[0105] A blockage coefficient drop test event set matching the downshift scenario to be calibrated is obtained; the downshift scenario to be calibrated is any downshift scenario; in the blockage coefficient drop test event set, a disturbance test event set in which the pumped material does not change is determined; a target value is determined; the blockage coefficients corresponding to at least a preset proportion of the disturbance test events in the disturbance test event set are not lower than a hysteresis lower limit value corresponding to the target value; the hysteresis lower limit value corresponding to the target value is the difference between a lower limit value of a preset blockage coefficient range corresponding to a high suction gear of the downshift scenario to be calibrated and the target value; based on the target value, a hysteresis value corresponding to the downshift scenario to be calibrated is obtained.

[0106] Each downshift scenario has a corresponding hysteresis value, and the hysteresis value corresponding to each downshift scenario can be calibrated in a test environment.

[0107] By simulating real clinical thrombus clearance scenarios in vitro, including vascular types (brachial axillary arteries and veins in the upper limbs, iliofemoral popliteal arteries and veins in the lower limbs, etc.), blood flow rate, blood density, and thrombus types (red thrombi, mixed thrombi, white thrombi, etc.), a circulatory arteriovenous blood circulation test platform was established.

[0108] After the test prototype with the sensor is connected to the suction catheter and the negative pressure suction pump, it is connected to the above-mentioned test platform to test the data collected by the pressure sensor in different downshift scenarios, so as to calibrate the hysteresis value corresponding to each downshift scenario.

[0109] The downgrade scenario Downgrade_3_2 is used as an example for description.

[0110] In the test environment, the current suction gear is set to the third suction gear, and the processing device calculates the blockage coefficient of the intelligent thrombus suction system in a certain cycle. If the blockage coefficient of the cycle falls to the preset blockage coefficient range corresponding to the second suction gear [R' B ,R' C ], the drop event is recorded as a blocking coefficient drop test event matching the downshift scenario Downgrade_3_2; the processing device can obtain Y blocking coefficient drop test events matching the downshift scenario Downgrade_3_2 through continuous monitoring, where Y is a positive integer greater than or equal to 1.

[0111] In the Y blocking coefficient drop test events, a blocking coefficient drop test event has a blocking coefficient drop to [R' B ,R' C ], but the pumped material remains unchanged, this blockage coefficient drop test event is considered a disturbance test event. Specifically, the processing device can use the tester's recorded information to determine X disturbance test events from the Y blockage coefficient drop test events, where X is a positive integer less than or equal to Y, and each disturbance test event has a corresponding blockage coefficient.

[0112] The high suction gear of the downshift scenario Downgrade_3_2 is the third suction gear, and the lower limit of the preset blocking coefficient range corresponding to the third suction gear is R' C .

[0113] Assume that X is 100 and the preset ratio is 99%. Determine a target value L', the lower limit value R' of the preset blockage coefficient range corresponding to the third suction gear C The difference between the target value L' is recorded as R' C-L', the target value is such that the blocking coefficient corresponding to at least 99 disturbance test events is not less than R' C The target value L' is used as the hysteresis value L_3_2 corresponding to the downshift scenario Downgrade_3_2.

[0114] In the above manner, hysteresis values ​​corresponding to other downshift scenarios can be determined.

[0115] This embodiment uses statistical data and analysis, referring to the 3σ principle in normal distribution, to determine the appropriate hysteresis value for each downshift scenario. This ensures that, in most cases, the intelligent thrombus aspiration system will operate in the desired aspiration gear, preventing unexpected operating state changes due to internal or external disturbances.

[0116] In one embodiment, controlling the patency of the suction catheter includes:

[0117] First, the voltage required to open the suction duct is applied to the solenoid valve of the suction duct according to the first duty cycle, and then the voltage required to open the suction duct is applied to the solenoid valve of the suction duct according to the second duty cycle to open the suction duct; the first duty cycle is higher than the second duty cycle.

[0118] After determining the current suction gear, the suction catheter can be intermittently opened and closed. To reduce the power consumption and heat generation of the solenoid valve of the suction catheter, during the solenoid valve's energizing phase, a higher first duty cycle can be applied to the solenoid valve of the suction catheter to achieve the required voltage for opening the suction catheter, thereby quickly opening the solenoid valve and establishing an initial negative pressure. During the solenoid valve's maintaining phase, a lower second duty cycle can be applied to the solenoid valve of the suction catheter to achieve the required voltage for opening the suction catheter, thereby maintaining a stable negative pressure and reducing coil heating and mechanical vibration.

[0119] The control method described above for the solenoid valve of the suction catheter is also applicable to the solenoid valve of the saline line. During the solenoid valve's energizing phase, the voltage required to open the saline line can be applied to the solenoid valve at a relatively high first duty cycle, thereby rapidly opening the valve and establishing an initial negative pressure. During the solenoid valve's maintaining phase, the voltage required to open the saline line can be applied to the solenoid valve at a relatively low second duty cycle, maintaining a stable negative pressure and reducing coil heating and mechanical vibration.

[0120] In order to better understand the above embodiment, an application example of the intelligent thrombus aspiration system of the present application is described in detail below.

[0121] The intelligent thrombus aspiration system provided by traditional technology cannot accurately locate the position of the thrombus during surgical treatment, and cannot perform fixed-point aspiration, so it can only perform range aspiration. Due to the large aspiration flow rate, the amount of blood loss of the aspirated subject will become very large. Usually, the aspirated subject will lose about 300 ml of blood, and even more than 400 ml of blood. The aspirated subject will have more complications, which brings great inconvenience to the recovery and treatment of the aspirated subject.

[0122] Traditional intelligent thrombus aspiration systems rely solely on doctors manually turning the system on and off through a purely physical process. For example, when bleeding is excessive, doctors first visually detect the condition, then search for the on / off button, and finally manually press and hold it to activate the on / off action. This process can take at least five seconds or even longer. A 12F aspiration catheter has a flow rate of at least 330mL / min, and each on / off action results in an additional 27.5mL of blood loss. In actual clinical practice, doctors may perform this on / off operation up to ten times, resulting in a high level of total blood loss. This manual operation also places greater demands on the doctor's skill. "F" is the French unit of measurement for the outer diameter of the aspiration catheter; the larger the number, the thicker the tube.

[0123] The suction of blood clots mainly relies on the negative pressure suction capacity of the vacuum pump. In traditional technology, the negative pressure of the better-performing vacuum pump can reach about 98Kpa (kilopascals), which is close to vacuum and can no longer significantly improve performance. Therefore, for harder blood clots that require greater suction force and blood clots in arterial blood vessels, if they cannot be sucked out at one time, then there is a high probability that they will not be able to be sucked out. The blood clot will be blocked at the tip of the suction catheter or inside the suction catheter. At this time, the doctor can only remove the suction catheter from the patient's blood vessel, manually clear the blocked part of the blood clot, and then re-enter the patient's blood vessel through the guide wire. The operation process will be more troublesome, which will greatly affect the suction efficiency of the operation.

[0124] The intelligent thrombus aspiration system provided in this embodiment is an intelligent thrombus aspiration system based on dynamic negative pressure regulation and multimodal feedback. The intelligent thrombus aspiration system automatically detects, measures, calculates, and controls thrombus aspiration in terms of hardware and software to reduce blood loss during aspiration surgery and improve aspiration efficiency.

[0125] The structure of the intelligent thrombus aspiration system is as follows: Figure 2The intelligent thrombus aspiration system includes a suction connector, a vacuum converter, and a connecting tube. To use, slowly insert the suction connector into the upper cover boss of the disposable collection bottle of the negative pressure suction pump. Plug the power cord into the power port of the negative pressure suction pump. Connect the Luer connector on the suction catheter connecting tube to the suction catheter and tighten it. Connect the bottle needle of the saline line to the saline solution and tighten it. Once installed, a passage is established between the negative pressure suction pump, the disposable suction connecting tube, and the suction catheter.

[0126] The structure of the attracting connector is as follows Figure 4 As shown, the suction connector includes a housing, a negative pressure suction pump connector, a three-way connector, a mainboard and a power connection line.

[0127] The structure of the vacuum converter is as follows Figure 5 As shown, the vacuum converter includes a housing, a three-way connector, a suction catheter connecting tube, a main board, a saline pipeline, a two-way connector, a solenoid valve and a suction connecting tube.

[0128] The hardware component of the intelligent thrombus aspiration system primarily consists of a processing device, which includes two main boards (e.g., PCBs). One board is located within the suction connector and contains a built-in first pressure sensor for dynamically detecting the pressure on the suction catheter near the negative pressure suction pump. This board also contains a built-in flow sensor for dynamically detecting the flow rate in the suction line and managing power supply for the entire system. PCB stands for Printed Circuit Board (PCB).

[0129] The other mainboard, located within the vacuum converter, houses a second pressure sensor for dynamically detecting the pressure on the suction catheter away from the negative pressure pump. This mainboard also contains an MCU chip, which receives real-time data from the first and second pressure sensors and the flow sensor. This chip analyzes and processes the data using an optimized algorithm, sending instructions to the solenoid valve to control the system's automatic suction. It also controls the status indicator and buzzer to display the system's real-time operating status. MCU stands for Microcontroller Unit (MCU).

[0130] Actual clinical needs include: reducing blood loss when blood is detected; increasing suction strength when a thrombus is detected; and using oscillating cycle suction when a large thrombus appears or the suction catheter is blocked to fatigue the thrombus itself or the part attached to the blood vessel wall, so that the thrombus can be successfully extracted.

[0131] Based on actual clinical needs, this application example provides an intermittent mode to reduce blood loss. In this mode, the suction catheter is intermittently opened and closed. Figure 6 , Figure 6The figure shows the pressure changes at the tip of the suction catheter (the end away from the vacuum pump) in intermittent mode. After the suction catheter is opened and connected to the vacuum pump, the pressure at the tip of the suction catheter decreases. Then, the suction catheter begins to close, isolating the tip from the vacuum pump and gradually increasing the pressure. When the suction catheter is completely closed, a "water hammer" effect occurs, causing the pressure at the tip of the suction catheter to rise to a positive pressure. Due to the damping effect of the liquid, the pressure at the tip of the suction catheter fluctuates. Then, as the suction catheter is reopened, the pressure at the tip of the suction catheter drops back to near the maximum negative pressure, and this cycle repeats.

[0132] To meet actual clinical needs, this application example provides an oscillation mode. Upon detecting a large thrombus or a clogged aspiration catheter, the system enters oscillation mode. In oscillation mode, the aspiration catheter and saline line are intermittently opened and closed, resulting in pulsed pressure changes at the aspiration catheter tip. The opening and closing of the aspiration catheter and the saline line can be controlled by corresponding solenoid valves.

[0133] When the tip of the suction catheter is blocked, the liquid in the suction catheter no longer flows. In intermittent mode, the suction catheter periodically opens and closes, which does not change the pressure at the tip of the suction catheter, and the suction catheter is always blocked. At this time, it can be switched to oscillation mode. Due to the addition of saline pipe intervention, the liquid in the entire pipe re-flows, causing the pressure at the tip of the suction catheter to change. Figure 7 , Figure 7 The figure shows the pressure changes at the tip of the suction catheter (the end away from the negative pressure pump) in oscillation mode. As the solenoid valve of the suction catheter opens, the pressure at the tip of the suction catheter continuously decreases to near the maximum negative pressure. However, due to the blockage of the suction catheter tip and the closed state of the pipeline, the pressure at the tip of the suction catheter cannot be released and remains near the maximum negative pressure for a period of time. As the solenoid valve of the suction catheter closes and the solenoid valve of the saline line opens, the pressure in the line is released, and the pressure at the tip of the suction catheter increases (the negative pressure decreases). Combined with the "water hammer" effect caused by the flowing liquid, the pressure at the tip of the suction catheter continues to rise to a positive pressure, with small fluctuations due to the damping effect of the liquid. Finally, the solenoid valve of the suction catheter opens again, and the solenoid valve of the saline line closes, causing the pressure in the line to decrease again. This cycle repeats, continuously generating a fluctuating pressure.

[0134] The intelligent thrombus aspiration system of this application example includes five aspiration gears, designated, from low to high, as the first, second, third, fourth, and fifth aspiration gears. The higher the aspiration gear, the longer the aspiration catheter remains open, and the greater the negative pressure suction force provided by the negative pressure suction pump. The fourth and fifth aspiration gears can be considered high aspiration gears. In these gears, the intelligent thrombus aspiration system alternately opens and closes the aspiration catheter and saline line.

[0135] When the aspiration catheter aspirates thrombi of varying sizes or hardness, the values ​​recorded by the first and second pressure sensors change. Larger and harder thrombi cause more severe clogging of the aspiration catheter. The pressure values ​​collected by the first and second pressure sensors, along with the values ​​from the flow sensor, are analyzed and processed to determine the current aspiration level. The MCU chip controls the aspiration catheter's solenoid valve to operate at a specific frequency to reduce blood loss from manual aspiration. Higher aspiration levels increase the frequency and effectively aspirate the thrombus. When in the fourth or fifth aspiration level, the MCU controls the saline line's solenoid valve and the aspiration catheter's solenoid valve to alternately operate at a specific frequency to achieve a transition between a vacuum state and the current ambient pressure in the system pipeline. This rapid adjustment breaks down any static friction from the thrombus at the aspiration port of the aspiration catheter, maintaining dynamic flow throughout the system. This adjustment fatigues the thrombus and allows for its rapid removal.

[0136] The MCU chip can also control light and sound indications according to real-time status. When in different suction gears, such as intermittent suction or continuous suction, the light and buzzer will present different states, such as always on or flashing at a certain frequency, short sounds or sounds of a certain frequency, etc. Surgeons at a distance can perform quick operations based on these real-time prompts to improve surgical efficiency.

[0137] The software in this application example is embedded. It includes data acquisition and processing, as well as solenoid valve and indicator light control functions. The MCU chip collects pressure data from the first and second pressure sensors, analyzes and processes the data using an internal embedded algorithm, and then controls the solenoid valve and indicator light to perform the corresponding actions, completing the suction process. Figure 8 It shows the software architecture and the interaction between software components.

[0138] Reference Figure 9 , Figure 9 This is the main program flow chart; after the software is started, the system is initialized and the cyclic pressure value collection begins. After obtaining the pressure value, it is processed according to the algorithm, the corresponding suction gear is determined, and a command is sent to the solenoid valve to perform the corresponding action, and the work is cyclically carried out.

[0139] Specifically, the system is initialized first, then the setting parameters are read. Then the watchdog is started and a loop is entered. The number of loops is first increased by 1 and the number of loops is checked to see if it is less than 16.

[0140] If not, jump directly to the step of processing the serial port receiving data, then execute the step of clearing the watchdog count, return to the step of "number of loops + 1", and continue the loop.

[0141] If so, execute "reset the number of cycles", then obtain the pressure value, display the suction gear and the serial port sending data, then execute the serial port receiving data processing step, and then execute the watchdog count reset step, return to the "number of cycles + 1" step, and continue the cycle.

[0142] Reference Figure 10 , Figure 10 This is a flow chart for determining the suction gear. After collecting the pressure value, the algorithm is used to process it to determine the blockage coefficient. Within the preset blockage coefficient range corresponding to the five suction gears, the preset blockage coefficient range is determined, and then the target suction gear is determined. Based on the relative height between the target suction gear and the current suction gear, a suction gear adjustment strategy is formed. Based on the suction gear adjustment strategy, the suction gear to be adjusted is determined. Figure 10 The shown “0x0F, 0x07, 0x03, 0x01, 0x00” is the hexadecimal representation of the five suction gears.

[0143] Reference Figure 11 ,pass Figure 11 The process shown can light up the corresponding indicator light according to the current suction gear, making it easy to intuitively observe the current operating status of the system.

[0144] Reference Figure 12 , Figure 12 This is a flowchart for processing parameter data received by the microprocessor's serial port. Different pressure parameters and delay parameters (such as hysteresis values) can be set externally. Specifically, upon receiving an interrupt indicating that the serial port has received data, the serial port receive processing begins. A determination is made as to whether the "frame header" is correct and the "frame length" is sufficient. If this determination is "no," the process ends. If it is "yes," the process then determines whether certain fixed characters in the data frame are correct. If this determination is "no," the process ends. If it is "yes," the parameter values ​​wa and wb (wa and wb are data codes for fixed positions in the data frame) are extracted from the data frame received by the serial port. The command word x is extracted from the data frame received by the serial port, and different processing flow branches are entered based on the value of the command word.

[0145] If the command word is "P", it indicates that the data frame is used to set the pressure parameters. The pressure parameters PA and PB are updated with two parameter values ​​wa and wb, that is, PA = wa, PB = wb; the parameters are saved to the EEPROM (Electrically Erasable Programmable Read-Only Memory) of the microcontroller so that the new parameters can be used after power is cycled; and the "Clear Receive Buffer" step is executed.

[0146] If the command word is "T", it indicates that the data frame is used to set the delay parameter, and the delay parameter PT is updated with the parameter value wb, that is, PT=wb; the parameters are saved to the EEPROM of the microcontroller so that the new parameters can continue to be used after power is restored; and the steps of "clearing the receive buffer" are executed.

[0147] If the command word is "S", it indicates that the data frame is used for parameter calculation. At this time, the processing is performed separately according to the value of the parameter calculation step sp.

[0148] If the parameter calculation step sp is equal to 0, then an intermediate variable PV0 in the parameter calculation is updated with the parameter value wb, that is, PV0=wb, and the parameter calculation step sp is changed to 1; and the step of "clearing the receive buffer" is executed.

[0149] If "the parameter calculation step sp is not equal to 0", then determine whether the parameter calculation step sp is equal to 2.

[0150] If the parameter calculation step sp is equal to 2, then an intermediate variable PV1 in the parameter calculation is updated with the parameter value wb, that is, PV1=wb, and the parameter calculation step sp is changed to 3; and the step of "clearing the receive buffer" is executed.

[0151] If the parameter calculation step sp is not equal to 2, execute the step of clearing the receiving buffer.

[0152] The intelligent thrombus aspiration system provided in this application example uses vacuum destruction and restoration to cyclically aspirate thrombi, reducing fatigue stress within the thrombus and even working on slightly harder thrombi, significantly improving aspiration efficiency. Furthermore, the intelligent thrombus aspiration system uses sensors to detect real-time data from the pipeline system and control the solenoid valve for intermittent aspiration. Compared to continuous aspiration, this system reduces blood loss in the aspirated patient. Flow sensors can also control overall blood loss, improving surgical safety and simplifying surgical procedures. Furthermore, the intelligent thrombus aspiration system operates automatically with millisecond-level data acquisition and control. The physician can simply operate the aspiration catheter to aspirate, eliminating the need to constantly control the disposable suction connection tube to control blood flow. Light and sound prompts allow the physician to quickly and clearly receive information about the current surgical status from a distance, allowing them to focus more on the aspirated patient and improving surgical efficiency.

[0153] It should be understood that, although the various steps in the flowcharts involved in the various embodiments described above are displayed in sequence according to the instructions of the arrows, these steps are not necessarily executed in sequence in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and these steps can be executed in other orders. Moreover, at least a portion of the steps in the flowcharts involved in the various embodiments described above can include multiple steps or multiple stages, and these steps or stages are not necessarily executed and completed at the same time, but can be executed at different times, and the execution order of these steps or stages is not necessarily to be carried out in sequence, but can be executed in turn or alternately with other steps or at least a portion of steps or stages in other steps.

[0154] In one embodiment, a processing device is provided, including a memory and a processor. The memory stores a computer program. When the processor executes the computer program, the steps performed by the processing device of the intelligent thrombus aspiration system described in any of the above embodiments are implemented.

[0155] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps performed by the processing device of the intelligent thrombus aspiration system described in any of the above embodiments are implemented.

[0156] In one embodiment, a computer program product is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps performed by the processing device of the intelligent thrombus aspiration system described in any of the above embodiments are implemented.

[0157] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of relevant data must comply with relevant regulations.

[0158] Those skilled in the art will appreciate that all or part of the processes in the above embodiments can be implemented by instructing the relevant hardware through a computer program. The computer program can be stored in a non-volatile computer-readable storage medium. When executed, the computer program can include the processes of the above embodiments. In particular, any reference to memory, database, or other media used in the embodiments provided in this application can include at least one of non-volatile memory and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM can take various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM). The databases involved in the various embodiments provided herein may include at least one of a relational database and a non-relational database. Non-relational databases may include, but are not limited to, blockchain-based distributed databases. The processors involved in the various embodiments provided herein may be, but are not limited to, general-purpose processors, central processing units (CPUs), graphics processing units (GPUs), digital signal processors (DSPs), programmable logic devices (PLDs), quantum computing-based data processing logic devices, artificial intelligence (AI) processors, and the like.

[0159] The technical features of the above embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this application.

[0160] The above-described embodiments merely represent several implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present application. It should be noted that a person of ordinary skill in the art may make various modifications and improvements without departing from the spirit of the present application, and these modifications and improvements fall within the scope of protection of the present application. Therefore, the scope of protection of the present application shall be determined by the appended claims.

Claims

1. An adaptive and dynamically adjustable intelligent thrombus aspiration system, characterized in that: The intelligent thrombus aspiration system includes: a processing device, an aspiration catheter, a negative pressure suction pump, a first pressure sensor and a second pressure sensor, wherein the first pressure sensor is used to monitor the pressure on the end of the aspiration catheter close to the negative pressure suction pump, and the second pressure sensor is used to monitor the pressure on the end of the aspiration catheter away from the negative pressure suction pump; The processing device performs the following steps: Controlling the intermittent opening and closing of the suction conduit according to the opening duration and closing duration corresponding to the current suction gear; Obtaining a blockage coefficient based on a proximal pressure value acquired by the first pressure sensor when the aspiration catheter is opened and a distal pressure value acquired by the second pressure sensor when the aspiration catheter is opened; Determining the preset blockage coefficient range in which the blockage coefficient is located within the preset blockage coefficient range corresponding to each suction gear; Obtaining a target suction gear according to the suction gear corresponding to the preset blockage coefficient range in which the blockage coefficient is located; If the target suction gear is higher than the current suction gear, a suction gear raising / lowering strategy is obtained based on an adjustment method for raising the suction gear from the current suction gear to the target suction gear; If the target suction gear is lower than the current suction gear, a hysteresis lower limit value is obtained according to the difference between the lower limit value of the preset blockage coefficient range corresponding to the current suction gear and the target hysteresis value. Based on the relative size between the hysteresis lower limit value and the blockage coefficient, it is determined whether to use an adjustment method based on lowering the current suction gear to the target suction gear to obtain a suction gear raising / lowering strategy.

2. The system according to claim 1, wherein: Obtaining a blockage coefficient according to a proximal pressure value acquired by the first pressure sensor when the suction catheter is opened and a distal pressure value acquired by the second pressure sensor when the suction catheter is opened, including: Obtaining a proximal pressure value at a final sampling moment and an average proximal pressure value based on several proximal pressure values ​​collected by the first pressure sensor when the suction catheter is opened; Obtaining a proximal pressure-related value based on the product of the proximal pressure average value and the confidence value; Obtaining a target proximal pressure value based on a relative magnitude between the proximal pressure-related value and the proximal pressure value at the last sampling moment; Obtaining a distal pressure value at a final sampling moment and an average distal pressure value based on several distal pressure values ​​collected by the second pressure sensor when the suction catheter is opened; Obtaining a distal pressure-related value based on a product of the distal pressure average value and the confidence value; Obtaining a target distal pressure value based on a relative magnitude between the distal pressure-related value and the distal pressure value at the last sampling moment; The obstruction coefficient is obtained according to the ratio between the target proximal pressure value and the target distal pressure value.

3. The system according to claim 1, wherein: Determining whether to adjust the suction gear from the current suction gear to the target suction gear based on the relative size between the hysteresis lower limit value and the blockage coefficient to obtain a suction gear raising / lowering strategy includes: If the blocking coefficient is greater than or equal to the hysteresis lower limit, a suction gear raising / lowering strategy is obtained by maintaining the current suction gear; If the blocking coefficient is less than the hysteresis lower limit, a suction gear raising / lowering strategy is obtained based on an adjustment method of lowering the current suction gear to the target suction gear.

4. The system according to claim 1, wherein: Determine the target hysteresis value, including: obtaining a target downshift scenario according to the current suction gear and the target suction gear; Among the hysteresis values ​​corresponding to the various downshift scenarios, a hysteresis value corresponding to the target downshift scenario is determined to obtain a target hysteresis value.

5. The system according to claim 4, characterized in that Determine the hysteresis value corresponding to each downshift scenario, including: Acquire a set of blocking coefficient drop test events that matches a downshift scenario to be calibrated; the downshift scenario to be calibrated is any downshift scenario; Determining a disturbance test event set in which the pumped material does not change within the blockage coefficient drop test event set; Determining a target value; wherein the blocking coefficients corresponding to at least a preset proportion of the disturbance test events in the disturbance test event set are not lower than a hysteresis lower limit value corresponding to the target value; and the hysteresis lower limit value corresponding to the target value is a difference between a lower limit value of a preset blocking coefficient range corresponding to the high suction gear of the downshift scenario to be calibrated and the target value; A hysteresis value corresponding to the downshift scenario to be calibrated is obtained according to the target value.

6. The system according to claim 1, wherein: Controlling the opening of the suction catheter includes: First, the voltage required to open the suction duct is applied to the solenoid valve of the suction duct according to a first duty cycle, and then the voltage required to open the suction duct is applied to the solenoid valve of the suction duct according to a second duty cycle, so that the suction duct is opened; the first duty cycle is higher than the second duty cycle.

7. The system according to claim 1, wherein: The intelligent thrombus aspiration system has multiple aspiration gears; the higher the aspiration gear, the longer the aspiration catheter is open, and the greater the negative pressure suction force provided by the negative pressure suction pump; The intelligent thrombus aspiration system further includes a saline pipeline. When the intelligent thrombus aspiration system is in a high aspiration gear, the aspiration catheter and the saline pipeline are alternately opened and closed.

8. A processing device comprising a memory and a processor, wherein the memory stores a computer program, wherein: When the processor executes the computer program, the steps performed by the processing device are implemented; the processing device belongs to the device in the adaptive dynamically adjusted intelligent thrombus aspiration system according to any one of claims 1 to 7.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by the processor, the steps performed by the processing device are implemented; the processing device belongs to the device in the adaptive dynamically adjusted intelligent thrombus aspiration system according to any one of claims 1 to 7.

10. A computer program product having a computer program stored thereon, characterized in that: When the computer program is executed by the processor, the steps performed by the processing device are implemented; the processing device belongs to the device in the adaptive dynamically adjusted intelligent thrombus aspiration system according to any one of claims 1 to 7.

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