Filling equipment and method for preparing ursodesoxycholic acid capsules

Abstract

The invention provides filling equipment and method for preparing ursodesoxycholic acid capsules, and belongs to the technical field of pharmacy, the filling equipment comprises a storage bin, a transmission mechanism, a feeding bin, a feeding hopper, a dispersing mechanism, a negative pressure machine, a heating dehumidifier and a scraping mechanism; the feeding hopper is fixedly installed on the storage bin, and a pulling-away hole is formed in the side wall of the feeding hopper. The dispersing mechanism is mounted in the feeding hopper, and a multi-surface elastic structure is arranged on the dispersing mechanism; the negative pressure machine is communicated with the extraction hole, and the heating dehumidifier is communicated with the interior of the storage bin; a transpiration cavity is formed in the heating dehumidifier; the scraping mechanism is installed on the feeding bin and provided with a rotator and a centrifugal scraping assembly. The filling equipment for preparing the ursodesoxycholic acid capsules can effectively eliminate negative effects on particle storage and feeding due to high humidity, and ensures that particles are efficiently and accurately filled in capsule filling operation.

Description

Technical Field

[0001] The invention belongs to the field of pharmaceutical technology, and more particularly relates to a filling device and a method for preparing ursodeoxycholic acid capsules. Background Art

[0002] Ursodeoxycholic acid (UDCA) is a hydrophilic secondary bile acid primarily produced through chemical synthesis or microbial conversion. Ursodeoxycholic acid capsules are manufactured directly using a capsule-filling machine. Ursodeoxycholic acid granules are pre-placed in a storage silo and then conveyed through a conveyor mechanism to a feed silo, which provides the granules for the capsule-filling machine. However, due to the high hygroscopicity of UDCA granules, efficient and accurate production is not possible during the high humidity of summer. Summary of the Invention

[0003] The object of the present invention is to provide a filling device and method for preparing ursodeoxycholic acid capsules, so as to solve the technical problem in the prior art that the ursodeoxycholic acid capsules cannot be produced efficiently and accurately due to the strong hygroscopicity of the particles.

[0004] To achieve the above-mentioned object, the technical solution adopted by the present invention is: to provide a filling device for preparing ursodeoxycholic acid capsules, comprising a storage bin, a transmission mechanism and a feed bin arranged and connected in sequence, and also comprising:

[0005] The feed hopper is fixedly mounted on the storage bin and has a draw-out hole on its side wall that communicates with the interior;

[0006] A dispersion mechanism is installed in the feed hopper and corresponds to the extraction hole; the dispersion mechanism has a multi-faceted elastic structure for contacting and dispersing the particles;

[0007] a negative pressure machine, connected to the extraction hole, for sucking the moist gas in the feed hopper;

[0008] A heating dehumidifier is connected to the interior of the storage bin; the heating dehumidifier is provided with a transpiration chamber for gas flow and humidity reduction;

[0009] A scraping mechanism is installed on the feed bin; the scraping mechanism has a rotator located inside the feed bin, and the rotator is provided with a centrifugal scraping component for elastically contacting the inner wall of the feed bin.

[0010] In one possible implementation, the dispersion mechanism includes an inclined supporting plate, one end of the supporting plate is fixedly connected to an inner wall of the feed hopper, and a material passing distance is provided between the other end and the other inner wall of the feed hopper; the multi-faceted elastic structure is installed on the supporting plate, and the multi-faceted elastic structure includes a plurality of convex elastomers and a plurality of concave elastomers arranged along the length direction of the supporting plate, the plurality of convex elastomers are arranged at intervals, and the plurality of concave elastomers are respectively located between two adjacent convex elastomers, and the adjacent convex elastomers and the concave elastomers are arranged tangentially.

[0011] In one possible implementation, the supporting plate is provided with mounting grooves for mounting the convex elastomer and the concave elastomer, and both sides of the supporting plate are corrugated plates adapted to the shapes of the multiple convex elastomers and the multiple concave elastomers; the convex elastomer and the concave elastomer are connected by a sliding fit.

[0012] In one possible implementation, the convex elastomer includes a first elastic member installed in the mounting groove and a first slider installed on the first elastic member, and the upper end surface of the first slider is a convex surface; the concave elastomer includes a second elastic member installed in the mounting groove and a second slider installed on the second elastic member, and the upper end surface of the second slider is a concave surface; the first slider and the second slider are connected in a sliding fit; the first slider is provided with a sliding groove and a third elastic member installed on the sliding groove, the second slider is provided with a sliding table slidingly connected to the sliding groove, and the lower end of the sliding table abuts against the third elastic member.

[0013] In one possible implementation, there are two supporting plates, which are arranged in the feed hopper with an upper and lower interval; one end of the two supporting plates is respectively fixed on the two opposite inner walls of the feed hopper; there are two groups of extraction holes, which correspond to the two supporting plates respectively; each group of extraction holes is arranged along the circumference of the feed hopper; the feed hopper includes a first barrel section located on the storage bin and a second barrel section located in the storage bin, and the two groups of extraction holes are respectively located on the first barrel section and the second barrel section.

[0014] In one possible implementation, the heating dehumidifier also includes a gas flow channel located in the evaporation chamber and arranged in a reciprocating and circuitous manner, and the gas flow channel is provided with a plurality of heating elements arranged along the length direction of the gas flow; the inlet of the gas flow channel is provided with a filter screen for blocking impurities.

[0015] In one possible implementation, the upper end of the feed bin is provided with a feed port and a mounting hole arranged at intervals, and the feed port is connected to the transmission mechanism; the rotator includes a drive motor and a rotating shaft, and the rotating shaft is located in the feed bin and is rotatably connected to the mounting hole; the number of the centrifugal scraping assemblies is multiple, and they are arranged along the length direction of the rotating shaft; the centrifugal scraping assembly includes a horizontal connecting rod, an arc-shaped mounting plate installed at one end of the horizontal connecting rod, and an elastic sliding member installed on the arc-shaped mounting plate away from the end of the horizontal connecting rod, and the elastic sliding member is used to contact the inner wall of the feed bin to scrape off particles located on the inner wall of the feed bin.

[0016] In one possible implementation, the arc-shaped mounting plate is provided with a plurality of grooves arranged in a rectangular array, and a limiting flange is provided at the opening of the groove; a fourth elastic member is provided in each of the grooves, the elastic sliding member is slidably connected in the groove, and has a limiting platform corresponding to the limiting flange; the lower end of the elastic sliding member abuts against the fourth elastic member, and the upper end is provided with a brush for contacting the inner wall of the feed bin.

[0017] In a possible implementation, projections of two adjacent arc-shaped mounting plates on the inner wall of the feed bin overlap in the height direction of the feed bin, and a plurality of the arc-shaped mounting plates are arranged in a spiral shape around the rotation axis.

[0018] The beneficial effects of the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention are as follows: Compared with the prior art, the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention utilizes a storage hopper, a transmission mechanism, and a feed hopper as the basic structure of the filling equipment for storing, transmitting, and supplying ursodeoxycholic acid particles. The feed hopper is fixed above the storage hopper, and an extraction hole is provided in the side wall for exhausting moist air. An internal dispersion mechanism is installed, whose core is a multi-faceted elastic structure that can disperse agglomerated particles through physical contact. A negative pressure device is connected to the extraction hole via a pipe, creating a negative airflow pressure, which extracts moist air from the feed hopper and reduces the humidity of the particles. A heating dehumidifier is connected to the interior of the storage hopper and has a transpiration chamber. It heats the air to form a dry airflow, which reduces the humidity of the gas entering the storage hopper and prevents moisture absorption and agglomeration. A scraping mechanism is installed in the feed hopper and includes a rotor and a centrifugal scraping assembly. When the rotor rotates, centrifugal force causes the scraping assembly to adhere to the inner wall of the feed hopper, scraping off adhered moist particles. The synergistic effects of dispersion, dehumidification, and heating mechanically break up aggregated particles, negative pressure extracts moist air, and allows dry air to enter. This triple action prevents moisture absorption and clumping of particles. Dynamic scraping then removes wet, sticky particles from the inner wall of the feed hopper, ensuring smooth feeding. This method effectively eliminates the negative impact of high humidity on particle storage and feeding, ensuring efficient and accurate production of particles during capsule filling operations.

[0019] Another object of the present invention is to provide a filling method for preparing ursodeoxycholic acid capsules, comprising any one of the above-mentioned filling devices for preparing ursodeoxycholic acid capsules, further comprising:

[0020] S1: Particles are added to the feed hopper and fall from top to bottom onto the dispersion mechanism. The particles hit the multi-faceted elastic structure and disperse toward the periphery. Moisture in the particle pile is exposed to the feed hopper.

[0021] S2: Start the negative pressure machine and the heating dehumidifier. The negative pressure machine forms a negative pressure in the feed hopper by means of the extraction hole, discharges the moisture in the feed hopper and the moisture in the storage bin; the heating dehumidifier heats and dehumidifies the gas before entering the storage bin;

[0022] S3: The particles enter the storage bin and are stored, and then enter the feed bin through the transmission mechanism;

[0023] S4: Starting the rotor in the scraping mechanism to drive the centrifugal scraping assembly to rotate in the feed bin. Under the action of centrifugal force, the centrifugal scraping assembly contacts the inner wall of the feed bin and scrapes off the particles on the inner wall of the feed bin; the particles are added to the filling machine from the feed bin.

[0024] The present invention provides a filling method for preparing ursodeoxycholic acid capsules. The method utilizes filling equipment for preparing ursodeoxycholic acid capsules. The method utilizes a collaborative approach of dispersion, dehumidification, and heating to mechanically break up agglomerated particles, extract moist air through negative pressure, and introduce dry air. This triple action prevents moisture absorption and agglomeration of particles. Dynamic scraping is then used to remove wet and sticky particles from the inner wall of the feed bin, ensuring smooth feeding. This method effectively eliminates the negative impact of high humidity on particle storage and feeding, ensuring efficient and accurate production of particles during the capsule filling operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0026] Figure 1 A schematic diagram of the internal structure of a filling device for preparing ursodeoxycholic acid capsules provided in an embodiment of the present invention;

[0027] Figure 2 A partial schematic diagram of a filling device for preparing ursodeoxycholic acid capsules provided in an embodiment of the present invention;

[0028] Figure 3 A schematic diagram of the connection between the feed hopper and the dispersion mechanism provided in an embodiment of the present invention;

[0029] Figure 4 A schematic structural diagram of a multi-faceted elastic structure provided by an embodiment of the present invention;

[0030] Figure 5 for Figure 4 Enlarged view of point A in the middle;

[0031] Figure 6 A schematic structural diagram of a heating dehumidifier provided in an embodiment of the present invention;

[0032] Figure 7 A schematic diagram of the connection between the feed bin and the scraping mechanism provided in an embodiment of the present invention;

[0033] Figure 8 A top view of a feed bin provided in an embodiment of the present invention;

[0034] Figure 9 A schematic structural diagram of a centrifugal scraping assembly provided in an embodiment of the present invention;

[0035] Figure 10 for Figure 9 Enlarged view of point B in the middle;

[0036] Figure 11 This is a front view of a filling device for preparing ursodeoxycholic acid capsules provided in an embodiment of the present invention.

[0037] Among them, the reference numerals in the figures are:

[0038] 10. Storage bin; 11. Transmission mechanism; 12. Feed bin; 13. Feed port; 14. Mounting hole; 20. Feed hopper; 21. Extraction hole; 22. First barrel section; 23. Second barrel section; 30. Dispersion mechanism; 31. Multi-faceted elastic structure; 32. Loading plate; 33. Feeding distance; 34. Convex elastic body; 341. First elastic member; 342. First slider; 343. Convex surface; 344. Slide; 345. Third elastic member; 35. Concave elastic body; 351. Second elastic member; 352. Second slider; 353 , concave surface; 354, slide; 36, mounting groove; 37, corrugated plate; 40, negative pressure machine; 41, pipeline; 50, heating dehumidifier; 51, evaporation chamber; 52, gas flow channel; 53, heating element; 54, filter; 60, scraping mechanism; 61, rotator; 62, centrifugal scraping assembly; 63, driving motor; 64, rotating shaft; 65, horizontal connecting rod; 66, arc-shaped mounting plate; 661, groove; 662, fourth elastic member; 663, limiting flange; 67, elastic sliding member; 68, limiting platform; 69, brush. DETAILED DESCRIPTION

[0039] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0040] It should be noted that when an element is referred to as being “fixed on” or “disposed on” another element, it may be directly on the other element or indirectly on the other element. When an element is referred to as being “connected to” another element, it may be directly connected to the other element or indirectly connected to the other element.

[0041] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0042] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature identified as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.

[0043] See also Figures 1 to 11 The filling device for preparing ursodeoxycholic acid capsules provided by the present invention is now described. A filling device for preparing ursodeoxycholic acid capsules comprises a storage bin 10, a transmission mechanism 11 and a feed bin 12 arranged and connected in sequence, and further comprises a feed hopper 20, a dispersion mechanism 30, a negative pressure machine 40, a heating dehumidifier 50 and a scraping mechanism 60; the feed hopper 20 is fixedly mounted on the storage bin 10, and a withdrawal hole 21 communicating with the interior is provided on the side wall; the dispersion mechanism 30 is mounted in the feed hopper 20 and corresponds to the withdrawal hole 21; the dispersion mechanism 30 has a device for contacting with particles and A multi-faceted elastic structure 31 for dispersing particles; a negative pressure machine 40 is connected to the extraction hole 21 and is used to suck the moist gas in the feed hopper 20; a heating dehumidifier 50 is connected to the inside of the storage bin 10; the heating dehumidifier 50 is provided with a transpiration chamber 51 for gas flow and reducing humidity; a scraping mechanism 60 is installed on the feed bin 12; the scraping mechanism 60 has a rotor 61 located inside the feed bin 12, and the rotor 61 is provided with a centrifugal scraping component 62 for elastic contact with the inner wall of the feed bin 12.

[0044] Compared with the prior art, the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention uses a storage bin 10, a transmission mechanism 11, and a feed bin 12 as the basic structure of the filling equipment, which is used to store, transmit and supply ursodeoxycholic acid particles. The feed hopper 20 is fixed above the storage bin 10, and an extraction hole 21 is provided on the side wall for discharging moist gas; a dispersion mechanism 30 is installed inside, and its core is a multi-faceted elastic structure 31 that can disperse agglomerated particles through physical contact. The negative pressure machine 40 is connected to the extraction hole 21 through a pipe 41, forming a negative air pressure, extracting the moist air in the feed hopper 20 and reducing the humidity of the particles. The heating dehumidifier 50 is connected to the inside of the storage bin 10, and is provided with a transpiration chamber 51. By heating the air, a dry airflow is formed, so that the humidity of the gas entering the storage bin 10 is low, thereby preventing moisture absorption and agglomeration. The scraping mechanism 60 is mounted on the feed hopper 12 and comprises a rotor 61 and a centrifugal scraper assembly 62. As the rotor 61 rotates, centrifugal force forces the scraper assembly to adhere to the inner wall of the feed hopper 12, scraping off any adhered damp particles. By synergizing dispersion, dehumidification, and heating, this triple action mechanically breaks up aggregated particles, negatively pressure extracts moisture, and introduces dry air. This prevents particles from absorbing moisture and clumping. Dynamic scraping then removes wet, sticky particles from the inner wall of the feed hopper 12, ensuring smooth feeding. This method effectively eliminates the negative impact of high humidity on particle storage and feeding, ensuring efficient and accurate filling of particles during capsule filling operations.

[0045] See also Figures 1 to 5As a specific embodiment of the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention, the dispersing mechanism 30 includes an inclined supporting plate 32, one end of the supporting plate 32 is fixedly connected to an inner wall of the feed hopper 20, and a material passing gap 33 is provided between the other end and the other inner wall of the feed hopper 20; a multifaceted elastic structure 31 is installed on the supporting plate 32, and the multifaceted elastic structure 31 includes a plurality of convex elastic bodies 34 and a plurality of concave elastic bodies 35 arranged along the length direction of the supporting plate 32, the plurality of convex elastic bodies 34 are arranged at intervals, and the plurality of concave elastic bodies 35 are respectively located between two adjacent convex elastic bodies 34, and the adjacent convex elastic bodies 34 and concave elastic bodies 35 are arranged tangentially; the dispersing mechanism 30 adopts an inclined supporting plate 32, one end of which is fixed to an inner wall of the feed hopper 20, and a material passing gap 33 is left between the other end and the other inner wall of the feed hopper 20 to facilitate the passage of particles. The multifaceted elastic structure 31 installed on the supporting plate 32 is composed of a plurality of convex elastic bodies 34 arranged at intervals along its length and concave elastic bodies 35 located between and tangent to adjacent convex elastic bodies 34. During operation, particles enter from the feed hopper 20 and slide down the inclined supporting plate 32 under the action of gravity. During the process, they will continuously collide with, rebound from, and change the direction of movement of the convex and concave elastic bodies 34 and 35 to achieve full dispersion. The beneficial effect of this design is that the multi-angle dispersion effect of the multifaceted elastic structure 31 on the particles effectively avoids particle agglomeration and ensures uniform dispersion of the particles, thereby improving the particle quality and filling uniformity of the ursodeoxycholic acid capsules and improving the quality and stability of capsule production. The convex and concave elastic bodies 34 and 35 are arranged in a tangential manner to avoid the situation where particles are stuck between the convex and concave elastic bodies 34 and 35.

[0046] See also Figures 3 to 5As a specific embodiment of the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention, a mounting groove 36 for mounting a convex elastic body 34 and a concave elastic body 35 is provided on the supporting plate 32. Corrugated plates 37 are provided on both sides of the supporting plate 32 to match the shapes of the multiple convex elastic bodies 34 and the multiple concave elastic bodies 35. The convex elastic bodies 34 and the concave elastic bodies 35 are connected in a sliding fit. The mounting groove 36 is provided on the supporting plate 32 to limit the convex elastic body 34 and the concave elastic body 35. The corrugated plates 37 are provided on both sides of the supporting plate 32 to match the shapes of the two elastic bodies. This ensures the stable installation of the convex elastic body 34 and the concave elastic body 35 and facilitates the sliding fit connection between the two. During operation, the convex elastic body 34 and the concave elastic body 35 are respectively inserted into the mounting groove 36 of the supporting plate 32. The relative position of the two elastic bodies can be flexibly adjusted by utilizing the sliding fit characteristics of the two. This design has significant benefits. On the one hand, the compatible installation of the corrugated plate 37 and the elastic body enhances the structural stability of the equipment and reduces component shaking during filling. On the other hand, the sliding fit between the convex elastic body 34 and the concave elastic body 35 prevents them from interfering with each other in the direction of movement. The concave elastic body 35 or the convex elastic body 34, which is connected to the sidewall of the mounting groove 36, is slidably connected to the support plate 32.

[0047] Preferably, there are multiple convex elastomers 34 and concave elastomers 35 in each row or column, and the two adjacent convex elastomers 34 and concave elastomers 35 in the same column or row are connected by sliding fit to avoid affecting the normal operation of other convex elastomers 34 and concave elastomers 35 due to the jamming of one or several convex elastomers 34 and concave elastomers 35.

[0048] See also Figure 4 and Figure 5As a specific embodiment of the filling device for preparing ursodeoxycholic acid capsules provided by the present invention, the convex elastic body 34 includes a first elastic member 341 installed in the installation groove 36 and a first slider 342 installed on the first elastic member 341, and the upper end surface of the first slider 342 is a convex surface 343; the concave elastic body 35 includes a second elastic member 351 installed in the installation groove 36 and a second slider 352 installed on the second elastic member 351, and the upper end surface of the second slider 352 is a concave surface 353; the first slider 342 and the second slider 352 are slidably connected; the first slider 342 is provided with a slide groove 344 and a third elastic member 345 installed on the slide groove 344; the second slider 352 is provided with a slide 354 slidably connected to the slide groove 344, and the lower end of the slide 354 abuts against the third elastic member 345. The convex elastic body 34 comprises a first elastic member 341 mounted within a mounting groove 36 and a first slider 342 mounted thereon. The first slider 342 has a convex surface 343 at its upper end. The concave elastic body 35 comprises a second elastic member 351 mounted within the mounting groove 36 and a second slider 352 mounted thereon. The second slider 352 has a concave surface 353 at its upper end. The two slides slidably engage with each other via the first and second sliders 342 and 352. Furthermore, the first slider 342 is provided with a slide groove 344 and a third elastic member 345 mounted therein. The second slider 352 is provided with a slide 354 that slidably engages with the slide groove 344. The lower end of the slide 354 abuts against the third elastic member 345. During operation, particles act downward on the convex surface 343 of the first slider 342 and the concave surface 353 of the second slider 352. The first and second elastic members 341 and 351 absorb and buffer the external force, causing deformation, thereby driving the first and second sliders 342 and 352 to move. This changes the positions of the first and second sliders 342 and 352, making the direction of particles acting on the convex and concave surfaces 343 and 353 more random, thereby improving the particle dispersion effect. Simultaneously, the slide 354, the chute 344, and the third elastic member 345 form an elastic sliding connection between the first and second sliders 342 and 352. As the second slider 352 moves downward, the force applied is transmitted to the first slider 342 via the slide 354 and the third elastic member 345, causing the first slider 342 to undergo displacement that is not caused by particles acting on the convex surface 343. This increases the randomness of the first slider 342's movement and improves the particle dispersion effect. Similarly, during this process, the first slider 342 reacts on the second slider 352, causing the second slider 352 to move without particles acting on the concave surface 353, thereby increasing the randomness of the movement of the second slider 352 and achieving a better particle dispersion effect.

[0049] See also Figures 1 to 3As a specific embodiment of the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention, there are two supporting plates 32, which are arranged in the feed hopper 20 with an upper and lower interval; one end of the two supporting plates 32 is respectively fixed on the two opposite inner walls of the feed hopper 20; there are two groups of extraction holes 21, which correspond to the two supporting plates 32 respectively; each group of extraction holes 21 is arranged along the circumference of the feed hopper 20; the feed hopper 20 includes a first barrel section 22 located on the storage bin 10 and a second barrel section 23 located in the storage bin 10, and the two groups of extraction holes 21 are respectively located on the first barrel section 22 and the second barrel section 23; two supporting plates 32 are arranged in the feed hopper 20 with an upper and lower interval, one end of which is respectively fixed to the two opposite inner walls of the feed hopper 20 to form a layered bearing structure, and the two groups of extraction holes 21 are respectively arranged along the circumference of the feed hopper 20 corresponding to the first barrel section 22 located on the storage bin 10 and the second barrel section 23 in the storage bin 10. During operation, particles enter the hopper 20 from the top and first land on the upper support plate 32, where they are dispersed by the multi-faceted elastic structure 31. The particles then pass through the feed gap 33 and land on the lower support plate 32, where they are further dispersed by the multi-faceted elastic structure 31, improving the dispersion of the particles. A first barrel section 22 and a second barrel section 23 are arranged on the hopper 20 to achieve segmented extraction. Furthermore, the extraction holes 21 within the second barrel section 23 create a negative pressure, which can also extract moisture from the storage bin 10. Each group of extraction holes 21 is multiple and arranged circumferentially along the first barrel section 22 or the second barrel section 23. A filter screen is provided on the extraction holes 21 to block particles. An annular cavity is installed on the first barrel section 22 to seal and cover the multiple extraction holes 21, and an annular cavity is installed on the second barrel section 23 to seal and cover the multiple extraction holes 21. Pipes 41 connect the two annular cavities to the negative pressure machine 40.

[0050] See also Figure 1 and Figure 5As a specific embodiment of the filling device for preparing ursodeoxycholic acid capsules provided by the present invention, the heating dehumidifier 50 also includes a gas flow channel 52 located in the evaporation chamber 51 and arranged in a reciprocating and circuitous manner, and a plurality of heating elements 53 arranged along the length direction of the gas flow are provided in the gas flow channel 52; a filter 54 for blocking impurities is provided at the inlet of the gas flow channel 52; the gas flow channel 52 arranged in a reciprocating and circuitous manner is provided in the evaporation chamber 51, which extends the flow path of the gas in the evaporation chamber 51, so that the gas can fully contact with the heating element 53, and the plurality of heating elements 53 arranged along the length direction of the gas flow in the gas flow channel 52 can continuously heat the flowing gas to ensure that the gas is effectively dehumidified; the filter 54 at the inlet of the gas flow channel 52 can prevent external impurities from entering the flow channel. The reciprocating and circuitous gas flow channel 52 cooperates with multiple heating elements 53 to improve the heating and dehumidification efficiency and effect of the gas, ensuring the dryness of the output gas; the filter 54 blocks impurities, improves the cleanliness of the gas entering the storage bin 10, reduces the adverse effects of impurities on the filling equipment and the quality of ursodeoxycholic acid capsules, and ensures the stability of the entire preparation process and product quality.

[0051] See also Figure 1 、 Figure 7 and Figure 8As a specific embodiment of the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention, the upper end of the feed bin 12 is provided with a feed port 13 and a mounting hole 14 arranged at intervals, and the feed port 13 is connected to the transmission mechanism 11; the rotator 61 includes a driving motor 63 and a rotating shaft 64, the rotating shaft 64 is located in the feed bin 12, and is rotatably connected to the mounting hole 14; the number of centrifugal scraping assemblies 62 is multiple, and they are arranged along the length direction of the rotating shaft 64; the centrifugal scraping assembly 62 includes a horizontal connecting rod 65, an arc-shaped mounting plate 66 installed at one end of the horizontal connecting rod 65, and an elastic sliding member 67 installed at the end of the arc-shaped mounting plate 66 away from the horizontal connecting rod 65, the elastic sliding member 67 is used to contact the inner wall of the feed bin 12 to scrape off particles located on the inner wall of the feed bin 12; the mounting hole 14 is arranged at the center position of the upper end of the feed bin 12, and the feed port 13 is eccentrically arranged at the upper end of the feed bin 12. The feed port 13 is connected to the conveyor mechanism 11 and is used to receive particles for filling capsules. The mounting hole 14 is used to mount the rotating shaft 64 of the rotator 61. The rotating shaft 64 is driven by a drive motor 63 to rotate within the feed hopper 12. Multiple centrifugal scraper assemblies 62 are arranged along the length of the rotating shaft 64. Each assembly consists of a horizontal connecting rod 65, a curved mounting plate 66, and an elastic slider 67, which is capable of contacting the inner wall of the feed hopper 12. The operation steps are as follows: the conveyor mechanism 11 delivers particles into the feed hopper 12 through the feed port 13. The drive motor 63 is activated to rotate the rotating shaft 64. As the centrifugal scraper assemblies 62 rotate with the rotating shaft 64, the elastic slider 67 slides against the inner wall of the feed hopper 12 under the action of centrifugal force, scraping particles adhering to the inner wall. The centrifugal scraper assemblies 62 automatically remove particles from the inner wall of the feed hopper 12. The elastic slider 67 adapts to the shape of the inner wall of the feed hopper 12, ensuring effective scraping.

[0052] See also Figure 1 、 Figure 7 、 Figures 9 to 11As a specific embodiment of the filling device for preparing ursodeoxycholic acid capsules provided by the present invention, a plurality of grooves 661 arranged in a rectangular array are provided on the arc-shaped mounting plate 66, and a limiting flange 663 is provided at the opening of the groove 661; a fourth elastic member 662 is provided in each groove 661, and an elastic sliding member 67 is slidably connected to the groove 661 and has a limiting platform 68 corresponding to the limiting flange 663; the lower end of the elastic sliding member 67 abuts against the fourth elastic member 662, and the upper end is provided with a stop for contacting the inner wall of the feed bin 12. The fourth elastic member 662 in each groove 661 provides an upward elastic support force for the elastic sliding member 67, so that the brush 69 at the upper end of the elastic sliding member 67 always keeps in contact with the inner wall of the feed bin 12. Specifically: when the rotator 61 is running, under the action of centrifugal force, the elastic sliding member 67 overcomes the elastic force of the fourth elastic member 662 in the groove 661 and slides outward, so that the brush 69 continues to be close to the inner wall of the feed bin 12 to clean the particles attached to the inner wall; and in this way, the brush 69 can adapt to the subtle changes in the inner wall of the feed bin 12, always maintain a good contact state, and effectively clean the residual particles on the inner wall; the multiple grooves 661 and the corresponding brushes 69 arranged in a rectangular array can clean the inner wall of the feed bin 12 in an all-round and efficient manner, improve the cleaning effect and work efficiency of the equipment, and ensure the stability of the ursodeoxycholic acid capsule filling process and product quality.

[0053] See also Figure 7 As a specific embodiment of the filling equipment for preparing ursodeoxycholic acid capsules provided by the present invention, the projections of two adjacent curved mounting plates 66 on the inner wall of the feed bin 12 overlap in the height direction of the feed bin 12, and multiple curved mounting plates 66 are arranged in a spiral shape around the rotating shaft 64. This arrangement of multiple curved mounting plates 66 means that each curved mounting plate 66 is staggered up and down along the height direction of the feed bin 12, so that the rotating curved mounting plates 66 and multiple elastic sliding members 67 can fully cover the inner wall of the feed bin 12, thereby completely scraping off the particles. The spiral arrangement of multiple curved mounting plates 66 creates a good stirring function within the entire feed bin 12, preventing the filling efficiency from being affected by particle accumulation or blockage.

[0054] Not shown in the figure, an embodiment of the present invention further provides a filling method for preparing ursodeoxycholic acid capsules. The filling method for preparing ursodeoxycholic acid capsules comprises any one of the above-mentioned filling devices for preparing ursodeoxycholic acid capsules, and further comprises:

[0055] S1: Particles are added to the feed hopper 20 and fall from top to bottom onto the dispersion mechanism 30. The particles hit the multi-faceted elastic structure 31 and disperse toward the periphery. The moisture in the particle pile is exposed to the feed hopper 20.

[0056] S2: Start the negative pressure machine 40 and the heating dehumidifier 50. The negative pressure machine 40 forms a negative pressure in the feed hopper 20 through the extraction hole 21, discharges the moisture in the feed hopper 20 and the moisture in the storage bin 10; the heating dehumidifier 50 heats and dehumidifies the gas before it enters the storage bin 10;

[0057] S3: The particles enter the storage bin 10 and are stored thereafter, and then enter the feed bin 12 through the transmission mechanism 11;

[0058] S4: The rotator 61 in the scraping mechanism 60 is started to drive the centrifugal scraping assembly 62 to rotate in the feed bin 12. Under the action of centrifugal force, the centrifugal scraping assembly 62 contacts the inner wall of the feed bin 12 and scrapes off the particles on the inner wall of the feed bin 12; the particles are added to the filling machine from the feed bin 12.

[0059] The filling method for preparing ursodeoxycholic acid capsules provided in an embodiment of the present invention utilizes the aforementioned filling equipment for preparing ursodeoxycholic acid capsules, with a storage bin 10, a transmission mechanism 11, and a feed bin 12 serving as the basic structure of the filling equipment for storing, transmitting, and supplying ursodeoxycholic acid particles. A feed hopper 20 is fixed above the storage bin 10, with an extraction hole 21 provided on the side wall for discharging moist air. An internal dispersion mechanism 30 is installed, the core of which is a multi-faceted elastic structure 31 that disperses agglomerated particles through physical contact. A negative pressure device 40 is connected to the extraction hole 21 via a pipe 41, creating a negative airflow pressure that extracts moist air from the feed hopper 20 and reduces particle humidity. A heating dehumidifier 50 is connected to the interior of the storage bin 10 and includes a transpiration chamber 51. This heats the air to form a dry airflow, reducing the humidity of the gas entering the storage bin 10 and preventing moisture absorption and agglomeration. The scraping mechanism 60 is mounted on the feed hopper 12 and comprises a rotor 61 and a centrifugal scraper assembly 62. As the rotor 61 rotates, centrifugal force forces the scraper assembly to adhere to the inner wall of the feed hopper 12, scraping off any adhered wet particles. Through the synergistic effect of dispersion, dehumidification, and heating, the mechanism mechanically breaks up agglomerated particles, while negative pressure extracts moist air and allows the entry of dry air. This triple action prevents moisture absorption and agglomeration. Dynamic scraping then removes wet, sticky particles from the inner wall of the feed hopper 12, ensuring smooth feeding. This method effectively eliminates the negative impact of high humidity on particle storage and feeding, ensuring efficient and accurate particle production during capsule filling operations.

[0060] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A filling device for preparing ursodeoxycholic acid capsules, comprising a storage bin, a transmission mechanism and a feed bin arranged and connected in sequence, characterized in that: Also includes: The feed hopper is fixedly mounted on the storage bin and has a draw-out hole on its side wall that communicates with the interior; A dispersion mechanism is installed in the feed hopper and corresponds to the extraction hole; the dispersion mechanism has a multi-faceted elastic structure for contacting and dispersing the particles; a negative pressure machine, connected to the extraction hole, for sucking the moist gas in the feed hopper; A heating dehumidifier is connected to the interior of the storage bin; the heating dehumidifier is provided with a transpiration chamber for gas flow and humidity reduction; A scraping mechanism is installed on the feed bin; the scraping mechanism has a rotator located inside the feed bin, and the rotator is provided with a centrifugal scraping component for elastically contacting the inner wall of the feed bin.

2. The filling device for preparing ursodeoxycholic acid capsules according to claim 1, characterized in that: The dispersing mechanism includes an inclined supporting plate, one end of the supporting plate is fixedly connected to an inner wall of the feed hopper, and a material passing distance is provided between the other end and the other inner wall of the feed hopper; the multi-faceted elastic structure is installed on the supporting plate, and the multi-faceted elastic structure includes a plurality of convex elastomers and a plurality of concave elastomers arranged along the length direction of the supporting plate, the plurality of convex elastomers are arranged at intervals, and the plurality of concave elastomers are respectively located between two adjacent convex elastomers, and the adjacent convex elastomers and the concave elastomers are arranged tangentially.

3. The filling device for preparing ursodeoxycholic acid capsules according to claim 2, characterized in that: The supporting plate is provided with mounting grooves for mounting the convex elastomer and the concave elastomer, and both sides of the supporting plate are corrugated plates adapted to the shapes of the multiple convex elastomers and the multiple concave elastomers; the convex elastomer and the concave elastomer are connected in a sliding fit.

4. The filling device for preparing ursodeoxycholic acid capsules according to claim 3, characterized in that: The convex elastomer includes a first elastic member installed in the mounting groove and a first slider installed on the first elastic member, and the upper end surface of the first slider is a convex surface; the concave elastomer includes a second elastic member installed in the mounting groove and a second slider installed on the second elastic member, and the upper end surface of the second slider is a concave surface; the first slider and the second slider are slidably connected; the first slider is provided with a slide groove and a third elastic member installed on the slide groove, and the second slider is provided with a slide table slidably connected to the slide groove, and the lower end of the slide table abuts against the third elastic member.

5. The filling device for preparing ursodeoxycholic acid capsules according to claim 2, characterized in that: There are two supporting plates, which are arranged in the feed hopper with an upper and lower interval; one end of the two supporting plates is respectively fixed on the two opposite inner walls of the feed hopper; there are two groups of extraction holes, which correspond to the two supporting plates respectively; each group of extraction holes is arranged along the circumference of the feed hopper; the feed hopper includes a first barrel section located on the storage bin and a second barrel section located in the storage bin, and the two groups of extraction holes are respectively located on the first barrel section and the second barrel section.

6. The filling device for preparing ursodeoxycholic acid capsules according to claim 1, characterized in that: The heating dehumidifier also includes a gas flow channel located in the evaporation chamber and arranged in a reciprocating and circuitous manner. The gas flow channel is provided with a plurality of heating elements arranged along the length direction of the gas flow; the inlet of the gas flow channel is provided with a filter screen for blocking impurities.

7. The filling device for preparing ursodeoxycholic acid capsules according to claim 1, characterized in that: The upper end of the feed bin is provided with a feed port and a mounting hole arranged at intervals, and the feed port is connected to the transmission mechanism; the rotator includes a driving motor and a rotating shaft, and the rotating shaft is located in the feed bin and is rotatably connected to the mounting hole; the number of the centrifugal scraping assemblies is multiple, and they are arranged along the length direction of the rotating shaft; the centrifugal scraping assembly includes a horizontal connecting rod, an arc-shaped mounting plate installed at one end of the horizontal connecting rod, and an elastic sliding member installed on the arc-shaped mounting plate away from one end of the horizontal connecting rod, and the elastic sliding member is used to contact the inner wall of the feed bin to scrape off particles located on the inner wall of the feed bin.

8. The filling device for preparing ursodeoxycholic acid capsules according to claim 7, characterized in that: The arc-shaped mounting plate is provided with a plurality of grooves arranged in a rectangular array, and a limiting flange is provided at the opening of the groove; a fourth elastic member is provided in each of the grooves, and the elastic sliding member is slidably connected in the groove and has a limiting platform corresponding to the limiting flange; the lower end of the elastic sliding member abuts against the fourth elastic member, and the upper end is provided with a brush for contacting the inner wall of the feed bin.

9. The filling device for preparing ursodeoxycholic acid capsules according to claim 8, characterized in that: The projections of two adjacent arc-shaped mounting plates on the inner wall of the feed bin overlap in the height direction of the feed bin, and the plurality of arc-shaped mounting plates are arranged in a spiral shape around the rotation axis.

10. A filling method for preparing ursodeoxycholic acid capsules, characterized in that: The filling device for preparing ursodeoxycholic acid capsules according to any one of claims 1 to 9 further comprises: S1: Particles are added to the feed hopper and fall from top to bottom onto the dispersion mechanism. The particles hit the multi-faceted elastic structure and disperse toward the periphery. Moisture in the particle pile is exposed to the feed hopper. S2: Start the negative pressure machine and the heating dehumidifier. The negative pressure machine forms a negative pressure in the feed hopper by means of the extraction hole, discharges the moisture in the feed hopper and the moisture in the storage bin; the heating dehumidifier heats and dehumidifies the gas before entering the storage bin; S3: The particles enter the storage bin and are stored, and then enter the feed bin through the transmission mechanism; S4: Starting the rotor in the scraping mechanism to drive the centrifugal scraping assembly to rotate in the feed bin. Under the action of centrifugal force, the centrifugal scraping assembly contacts the inner wall of the feed bin and scrapes off the particles on the inner wall of the feed bin; the particles are added to the filling machine from the feed bin.

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