Traditional Chinese medicine combination prescription for livestock diseases and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine combined prescription for livestock diseases and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine combined prescription for livestock diseases is prepared from the following traditional Chinese medicines in parts by weight: gypsum, radix rehmanniae, radix scrophulariae, radix isatidis, folium isatidis, cortex phellodendri, scutellaria baicalensis, coptis chinensis, gardenia jasminoides, rhubarb, rhizoma anemarrhenae, platycodon grandiflorum and liquorice. When the prescription is prepared into a veterinary drug, the prescription further comprises pharmaceutically acceptable auxiliary materials, and the auxiliary materials are selected from one or more of starch, dextrin, cane sugar and microcrystalline cellulose. The dosage form of the prescription comprises powder, granules or oral liquid. Through scientific proportioning, a multi-target synergistic effect system of antipyretic-antiviral-antibacterial-immunoregulation is formed, various compound diseases such as wind-heat type common cold and pneumonia of livestock can be treated at the same time, the complexity of repeated medication of a single disease is reduced, the prevention and treatment efficiency is improved, various livestock diseases are comprehensively prevented and treated, the types of medication are reduced, and the breeding efficiency is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine combination prescription for livestock diseases and a preparation method thereof. Background Art

[0002] With the large-scale and intensive development of modern animal husbandry, the effective prevention and treatment of livestock diseases (such as high fever, respiratory infections, and gastrointestinal inflammation) has become a core link in ensuring breeding efficiency, and is related to the sustainable development of the industry and the foundation of food safety. With the continuous increase in breeding density, the pressure on the living environment of livestock and poultry has intensified, and the risk of pathogen transmission has increased exponentially. Establishing an efficient prevention and control system that integrates precise diagnosis, scientific medication, and biosafety control is not only the key to improving breeding efficiency and enhancing industry competitiveness, but also an important support for maintaining national food security and promoting the implementation of the rural revitalization strategy.

[0003] Currently, prevention and treatment methods on the market are mainly divided into two categories: chemical drugs (such as antibiotics) and traditional Chinese medicine prescriptions. Although chemical drugs are more effective, long-term use can easily lead to problems such as excessive drug residues, drug resistance, and ecological damage to the breeding environment, seriously affecting the safety of livestock products and the sustainability of breeding. Traditional Chinese medicine prescriptions generally suffer from the defects of single formulas and lack of synergy. For example, using only a single antiviral or antibacterial ingredient as the main drug is difficult to treat complex diseases and cannot meet the needs of large-scale breeding for efficient, safe, and convenient solutions. Summary of the Invention

[0004] The purpose of the present invention is to provide a Chinese medicine combination prescription for livestock diseases and a preparation method thereof, which solves the technical problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solution: a traditional Chinese medicine combination prescription for livestock diseases, composed of the following traditional Chinese medicines in parts by weight: 2000g-4000g of gypsum, 900g-2000g of raw rehmannia, 900g-2000g of scrophulariae, 900g-2000g of isatis root, 900g-2000g of isatis indigotica, 900g-2000g of phellodendron, 900g-2000g of scutellaria, 900g-2000g of coptis chinensis, 900g-2000g of gardenia, 900g-2000g of chuanxiong, 900g-2000g of anemarrhena, 900g-2000g of platycodon, and 900g-2000g of liquorice.

[0006] Preferably, it is made from the following raw materials, in parts by weight: 3000g of gypsum, 1000g of raw rehmannia, 1000g of scrophulariae, 1000g of isatis root, 1000g of isatis indigotica, 1000g of phellodendron, 1000g of scutellaria, 1000g of coptis chinensis, 1000g of gardenia, 1000g of chuanxiong, 1000g of anemarrhena, 1000g of platycodon, and 1000g of licorice.

[0007] Preferably, when the prescription is prepared as a veterinary medicine, it further comprises a pharmaceutically acceptable excipient, wherein the excipient is selected from one or more of starch, dextrin, sucrose, and microcrystalline cellulose.

[0008] Preferably, the dosage form of the prescription includes powder, granules or oral liquid preparation, wherein the moisture content of the powder and granules is ≤9.0%, and the pH value of the oral liquid preparation is in the range of 4.5-7.5.

[0009] A method for preparing a traditional Chinese medicine combination prescription for livestock diseases comprises the following steps:

[0010] (1) Weigh each medicinal material according to the above ratio;

[0011] (2) Place all the medicinal materials into processing equipment that meets the processing standards of traditional Chinese medicines at the same time or in sequence without any requirement for processing;

[0012] (3) After processing, transfer the resulting drug to a clean, disinfected place and stir it with a stirring device for at least 10 minutes until it is evenly mixed.

[0013] Preferably, the processing equipment in step (2) includes a traditional Chinese medicine grinder or extraction and concentration equipment; when a grinding process is adopted, the fineness of the powder after grinding is ≥80 mesh.

[0014] Compared with the related art, the Chinese medicine combination prescription for livestock diseases provided by the present invention has the following beneficial effects:

[0015] 1. The present invention provides a traditional Chinese medicine combination prescription for livestock diseases, with a three-dimensional prevention and treatment system: through scientific proportioning, a multi-target synergistic system of "antipyretic-antiviral-antibacterial-immunomodulatory" is formed, which can simultaneously deal with multiple complex diseases such as wind-heat colds and pneumonia in livestock, reduce the tediousness of repeated medication for a single disease, improve prevention and treatment efficiency, and comprehensively prevent and treat multiple livestock diseases, reduce the types of medications, and improve breeding efficiency.

[0016] 2. The present invention provides a traditional Chinese medicine combination prescription for livestock diseases, which is green, safe, and has no drug residues. The formula is composed entirely of natural Chinese medicinal materials, does not contain antibiotics and chemical synthetic drugs, and has been clinically verified to have no drug residues, meeting the strict requirements of modern green breeding for food safety. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0018] The invention provides a technical solution: a traditional Chinese medicine combination prescription for livestock diseases, which is composed of the following traditional Chinese medicines in parts by weight: 2000g-4000g of gypsum, 900g-2000g of raw rehmannia, 900g-2000g of figwort, 900g-2000g of isatis root, 900g-2000g of isatis indigotica, 900g-2000g of phellodendron, 900g-2000g of scutellaria, 900g-2000g of coptis chinensis, 900g-2000g of gardenia, 900g-2000g of chuanxiong, 900g-2000g of anemarrhena, 900g-2000g of platycodon, and 900g-2000g of liquorice.

[0019] When the prescription is prepared into a veterinary medicine, it also includes pharmaceutically acceptable excipients, which are selected from one or more of starch, dextrin, sucrose, and microcrystalline cellulose.

[0020] The dosage forms of the prescription include powder, granules or oral liquid preparations, wherein the moisture content of the powder and granules is ≤9.0%, and the pH value range of the oral liquid preparation is 4.5-7.5.

[0021] A method for preparing a traditional Chinese medicine combination prescription for livestock diseases comprises the following steps:

[0022] (1) Weigh each medicinal material according to the above ratio;

[0023] (2) Place all the medicinal materials into processing equipment that meets the processing standards of traditional Chinese medicines at the same time or in sequence without any requirement for processing;

[0024] (3) After processing, transfer the resulting drug to a clean, disinfected place and stir it with a stirring device for at least 10 minutes until it is evenly mixed.

[0025] Wherein, the processing equipment in step (2) includes a Chinese medicine grinder or extraction and concentration equipment; when a grinding process is adopted, the fineness of the powder after grinding is ≥80 mesh.

[0026] The following are specific embodiments:

[0027] Example 1: Powder Preparation (Preferred Ratio)

[0028] Recipe: 3000g gypsum, 1000g raw rehmannia, 1000g Scrophularia, 1000g isatis root, 1000g isatis leaf, 1000g phellodendron, 1000g scutellaria, 1000g coptis root, 1000g gardenia, 1000g chuanxiong, 1000g anemarrhena, 1000g platycodon, 1000g licorice.

[0029] Excipients: 200g microcrystalline cellulose (2% of the total weight of the medicinal material).

[0030] Preparation method:

[0031] 1) Weigh 13 herbs according to the following ratios: gypsum, radix rehmanniae, radix scrophulariae, root of isatis indigotica, leaf of isatis indigotica, cortex phellodendri, radix scutellariae, rhizoma coptidis, jasmine gardeniae, rhizoma anemarrhenae, rhizoma anemarrhenae, platycodon grandiflorum, and liquorice;

[0032] 2) Put all the medicinal materials into a traditional Chinese medicine grinder and grind them to a fineness of ≥80 mesh;

[0033] 3) Transfer the powder to a clean mixing tank, add microcrystalline cellulose, and stir at 60 rpm for 15 minutes until uniform;

[0034] 4) The moisture content (5.8%) was tested and met the standard for powder (≤9.0%), and the product was packaged into 100 g / bag.

[0035] Example 2: Preparation of granules (floating ratio)

[0036] Recipe: 2500g gypsum, 950g raw rehmannia, 950g Scrophularia, 950g isatis root, 950g isatis leaf, 950g phellodendron, 1500g scutellaria, 950g coptis root, 950g gardenia, 950g chuanxiong, 950g anemarrhena, 950g platycodon, 950g licorice.

[0037] Auxiliary materials: dextrin 300g + sucrose 150g (accounting for 4.5% of the total weight of the medicinal materials).

[0038] Preparation method:

[0039] 1) The medicinal materials are processed by a crusher (fineness ≥ 80 mesh);

[0040] 2) Mix the drug powder with dextrin and sucrose, and add purified water to prepare a soft material;

[0041] 3) Granulate with a swing granulator (16-mesh screen) and dry with hot air at 60°C to a moisture content of 7.2% (≤9.0%);

[0042] 4) After granulation, the mixture is divided into 50g / bag granules.

[0043] Example 3: Preparation of oral liquid (floating ratio)

[0044] Recipe: 3500g gypsum, 1100g raw rehmannia, 1100g Scrophularia, 1100g isatis root, 1100g isatis leaf, 1100g phellodendron, 1800g scutellaria, 1100g coptis root, 1100g gardenia, 1100g chuanxiong, 1100g anemarrhena, 1100g platycodon, 1100g licorice.

[0045] Preparation method:

[0046] 1) Place the medicinal materials into a multifunctional extraction tank, add 8 times the amount of water and boil twice (1.5 hours for the first time and 1 hour for the second time);

[0047] 2) The filtrates were combined and concentrated under reduced pressure to a relative density of 1.15 (60°C);

[0048] 3) The concentrate was adjusted to pH 6.0 (range 4.5-7.5) and 0.1% potassium sorbate was added;

[0049] 4) Filled into 100mL / bottle of oral solution.

[0050] Example 4: Clinical efficacy verification

[0051] Experimental Design:

[0052] Subjects: 60 fattening pigs (average weight 35 kg) with respiratory diseases were randomly divided into 4 groups, 15 pigs in each group.

[0053] plan:

[0054] Test group 1: Example 1 powder (preferred ratio), mixed into feed at 1 g / kg body weight, and used for 7 consecutive days.

[0055] Test group 2: Example 2 granules (floating ratio), 2 g / kg body weight mixed feed or oral administration, for 5 consecutive days.

[0056] Experimental group 3: Example 3 oral solution (floating ratio), directly administered orally at 2 mL / kg body weight, twice a day for 5 consecutive days.

[0057] Control group: Amoxicillin (conventional antibiotic), 20 mg / kg body weight intramuscular injection, for 7 consecutive days.

[0058] Efficacy criteria: normalization of body temperature, cessation of cough, and recovery of appetite were used as effective judgment indicators. The effective rate, onset time, and recurrence rate of each group were recorded.

[0059] Table 1:

[0060] Group Solution Effectiveness (%) Time to effect (days) Recurrence rate (%) Experimental group 1 Example 1 powder 95.0％ 2-4 days 2.0％ Experimental Group 2 Example 2 Granules 88.0％ 3-5 days 5.0％ Experimental Group 3 Example 3 Oral Liquid 90.0％ 1-3 days 3.0％ control group Amoxicillin (conventional antibiotic) 76.7％ 5-7 days 13.3％

[0061] As can be seen from Table 1, the different dosage forms of drugs used in the three test groups all showed clinical efficacy that was superior to that of the control group (amoxicillin conventional antibiotic). From the perspective of effectiveness, the powder of Example 1 used in Test Group 1 ranked first with an effectiveness of 95.0%, significantly higher than the 76.7% of the control group, indicating that the powder with the preferred ratio was effective in promoting the return of body temperature to normal, stopping coughing, and restoring appetite in sick pigs; the granules of Example 2 in Test Group 2 had an effectiveness of 88.0%, and the oral liquid of Example 3 in Test Group 3 had an effectiveness of 90.0%, both of which were significantly better than the control group, confirming that the self-developed drug dosage form has reliable therapeutic value in clinical application.

[0062] Comparison of onset times further highlights the rapid effectiveness of the experimental group drugs. The oral solution in Experimental Group 3 took effect in as little as one day, with an average onset time significantly shorter than the 5-7 days in the control group. This indicates that this formulation can rapidly act on sick pigs, promptly alleviating respiratory symptoms. While the powder in Experimental Group 1 and the granules in Experimental Group 2 took slightly longer to take effect, they also demonstrated therapeutic efficacy within 2-4 days and 3-5 days, respectively, significantly shortening the course of illness compared to the control group.

[0063] The experimental groups showed a significant advantage in relapse rates. The relapse rate for the powder in Experimental Group 1 was only 2.0%, while that for the granules in Experimental Group 2 and the oral solution in Experimental Group 3 was 5.0% and 3.0%, respectively—all significantly lower than the 13.3% relapse rate in the control group. This demonstrates that the self-developed drug not only effectively treats the disease but also enhances the immune system of sick pigs, reducing the risk of recurrence. Conventional antibiotic treatment is more likely to lead to relapses in sick pigs, demonstrating the significant advantages of the self-developed drug in consolidating treatment outcomes and improving the sustainability of animal health.

[0064] Example 5: Examples of dosage adjustments for different livestock

[0065] Table 2:

[0066] livestock species Dosage form Recommended dosage usage pig powder 1-2g / kg body weight Mixing feed and feeding ox Granules 5-10g / head (based on body weight) Mixed feed or oral administration sheep oral solution 1-1.5 mL / kg body weight Direct oral administration birds powder 0.5-1g / piece Mix into feed

[0067] The above are only preferred specific embodiments of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with this technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solutions and inventive concepts of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A Chinese medicinal combination prescription for livestock diseases, characterized in that: The invention is composed of the following traditional Chinese medicines in parts by weight: 2000g-3000g of gypsum, 900g-1000g of raw rehmannia, 900g-1000g of scrophulariae, 900g-1000g of isatis root, 900g-1000g of isatis leaf, 900g-1000g of phellodendron, 900g-1000g of scutellaria, 900g-2000g of coptis root, 900g-1000g of gardenia, 900g-1000g of chuanxiong, 900g-1000g of anemarrhena, 900g-1000g of platycodon, and 900g-1000g of liquorice.

2. A Chinese medicinal combination prescription for livestock diseases according to claim 1, characterized in that: The product is made from the following raw materials in parts by weight: 3000g of gypsum, 1000g of raw rehmannia, 1000g of scrophulariae, 1000g of isatis root, 1000g of isatis leaf, 1000g of phellodendron, 1000g of scutellaria, 1000g of coptis root, 1000g of gardenia fruit, 1000g of chuanxiong, 1000g of anemarrhena, 1000g of platycodon, and 1000g of liquorice.

3. The Chinese medicinal combination prescription for livestock diseases according to claim 1, characterized in that: When the prescription is prepared into a veterinary medicine, it also includes pharmaceutically acceptable excipients, which are selected from one or more of starch, dextrin, sucrose, and microcrystalline cellulose.

4. The Chinese medicinal combination prescription for livestock diseases according to claim 1, characterized in that: The dosage form of the prescription includes powder, granule or oral liquid preparation, wherein the water content of the powder and granule is less than or equal to 9.0%, and the pH value of the oral liquid preparation is in the range of 4.5-7.

5.

5. A method for preparing a Chinese medicinal combination prescription for livestock diseases according to any one of claims 1 to 4, characterized in that: The following steps are involved: (1) Weigh each medicinal material according to the ratio described in claim 1; (2) Place all the medicinal materials into processing equipment that meets the processing standards of traditional Chinese medicines at the same time or in sequence without any requirement for processing; (3) After processing, transfer the resulting drug to a clean, disinfected place and stir it with a stirring device for at least 10 minutes until it is evenly mixed.

6. The method for preparing a Chinese medicinal combination prescription for livestock diseases according to claim 5, characterized in that: The processing equipment in step (2) includes a Chinese medicine grinder or extraction and concentration equipment; when a grinding process is adopted, the fineness of the powder after grinding is ≥80 mesh.