Traditional Chinese medicine composition for treating exercise-induced knee joint pain as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating exercise-induced knee joint pain as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines, the traditional Chinese medicine composition comprises a traditional Chinese medicine A, a traditional Chinese medicine B and a traditional Chinese medicine C, the traditional Chinese medicine A comprises the following raw materials: ground beetles, scorpions, centipedes, earthworms, processed rhizoma arisaematis, bombyx batryticatus, rhizoma smilacis glabrae, safflowers, cocklebur fruits, processed radix aconiti and processed radix aconiti agrestis The traditional Chinese medicine B is prepared from the following raw materials: radix angelicae sinensis, flos carthami, radix achyranthis bidentatae, ground beeltle, rhizoma chuanxiong, radix saposhnikoviae, rhizoma drynariae, frankincense, myrrh and rhizoma zingiberis; the traditional Chinese medicine C is prepared from the following raw materials: radix angelicae sinensis, radix angelicae, pericarpium citri reticulatae, fructus aurantii, cortex cinnamomi, rhizoma atractylodis macrocephalae, grape seeds and radix astragali. The three components are cooperatively and externally applied to the knee joint, transdermal absorption of the medicine is promoted by means of heating power, local blood vessels are expanded, microcirculation is improved, vasospasm is relieved, the medicine directly reaches the focus through tendon warming and collateral dredging effects, and the symptoms such as joint soreness, numbness, swelling and movement disorder are rapidly relieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicines and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating sports-induced knee pain, a preparation method and application. Background Art

[0002] The idea of exercising to stay healthy is deeply rooted in people's minds, but unscientific exercise can lead to sports injuries. Among those who choose running as a form of exercise, exercise-induced knee pain is common, affecting not only the ability to continue exercising but also normal life and work, reducing quality of life.

[0003] Sports-induced knee pain falls under the category of "knee arthritis" and "tendon injury" in Traditional Chinese Medicine (TCM). Its pathogenesis is characterized by underlying deficiency and superficial excess, often due to sports-related strain leading to imbalances in Qi and blood, invasion by exogenous pathogens, and liver and kidney deficiency. Traditional Chinese Medicine believes that long-term exercise or excessive load can damage tendons and vessels, leading to Qi and blood stagnation and blocked meridians. Symptoms of excess syndrome include cold, heavy pain in the knee (cold-dampness obstruction), redness, swelling, and burning (damp-heat accumulation), or fixed stabbing pain (Qi stagnation and blood stasis), often accompanied by difficulty flexing and extending, tenderness that resists pressure, and a tongue coating that is often smooth, white, greasy, or dark purple. Deficiency syndrome, caused by liver and kidney deficiency and both Qi and blood deficiency, presents with knee weakness, dull pain, exacerbated by exertion, accompanied by soreness in the lower back and knees, fatigue, a pale tongue, and a weak pulse. If untreated, it can progress to the accumulation of phlegm and blood stasis, tendon adhesions, and even joint stiffness and deformation, seriously impairing motor function. Currently, Western medical treatments primarily rely on nonsteroidal anti-inflammatory drugs (NSAIDs) or local blockades. While these drugs can provide short-term pain relief, long-term use can easily lead to side effects such as gastrointestinal damage and drug resistance, and they struggle to address the root causes of the disease while simultaneously treating the symptoms and the root cause. Existing Traditional Chinese Medicine (TCM) formulas often focus on a single pathogenesis (e.g., simply dispelling cold and dampness or replenishing Qi and blood), lacking the coordinated regulation of the complex pathogenesis of "liver and kidney deficiency as the root cause and blood stasis caused by exogenous pathogens" (exogenous pathogens), resulting in limited efficacy. Therefore, there is an urgent need to develop a TCM combination that simultaneously nourishes the liver and kidneys, harmonizes Qi and blood, dispels wind and dampness, and dredges the meridians to relieve pain, in order to address the multi-dimensional pathological associations of sports-related knee pain and achieve the therapeutic goal of restoring muscle and bone function from the root. Summary of the Invention

[0004] The present invention provides a traditional Chinese medicine composition for treating sports-induced knee joint pain, a preparation method and application thereof, so as to overcome the defects of the prior art.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A, traditional Chinese medicine B and traditional Chinese medicine C; the raw materials of the traditional Chinese medicine A include: Chinese earthworm, scorpion, centipede, earthworm, processed arisaema, bombyx batryticatus, smilax glabra, safflower, Xanthium sibiricum, processed Chuanwu and processed Aconitum kusnezoffii; the raw materials of the traditional Chinese medicine B include: Chinese angelica, safflower, Achyranthes bidentata, Chinese earthworm, Chuanxiong, Saposhnikovia divaricata, Drynaria fortunei, frankincense, myrrh and dried ginger; the raw materials of the traditional Chinese medicine C include: Chinese angelica, Angelica dahurica, dried tangerine peel, fructus aurantii, cinnamon bark, Atractylodes macrocephala, grape seed and astragalus.

[0007] Among them, in Traditional Chinese Medicine A, Eupolyphaga sinensis, scorpion, centipede, earthworm, and safflower are used to dredge meridians, promote blood circulation and remove blood stasis, and relieve pain; Xanthium sibiricum, processed Chuanwu, and processed Caowu are used to dispel cold and dampness, and warm the joints; processed Arisaema confusa and Bombyx batryticatus are used to dry dampness and resolve phlegm, dispel wind and stop spasms; and Smilax glabra is used to clear heat and dampness, detoxify and resolve nodules. In Traditional Chinese Medicine B, Angelica sinensis, safflower, Achyranthes bidentata, Eupolyphaga sinensis, and Chuanxiong are used to synergistically clear blood stasis and relieve pain; Drynaria fortunei, frankincense, and myrrh are used to strengthen tendons and bones and promote repair; Saposhnikovia divaricata is used to dispel wind and dampness, relieve pain, and stop spasms; and dried ginger is used to warm the middle and dispel cold. In Chinese medicine C, angelica and astragalus are used to replenish qi and blood, and harmonize meridians; cinnamon, white atractylodes and angelica dahurica are used to relieve pain, dispel cold and dampness, promote blood circulation, promote skin repair, and enhance immunity; grape seeds are used for anti-oxidation, moisturizing, detoxification and skin protection; tangerine peel and tangerine peel are used for moisturizing, antibacterial, anti-inflammatory, and mood soothing.

[0008] Furthermore, the weight parts of the raw materials in the Chinese medicine A are: 90-110 parts of Eupolyphaga sinensis, 90-110 parts of Scorpio scorpion, 20-40 parts of Scolopendra centipede, 90-110 parts of earthworm, 40-60 parts of processed Arisaema, 40-60 parts of Bombyx batryticatus, 40-60 parts of Smilax glabra, 40-60 parts of Carthamus tinctorius, 20-40 parts of Xanthium sibiricum, 20-40 parts of processed Chuanwu, and 20-40 parts of processed Kusnezoffius kusnezoffii; the weight parts of the raw materials in the Chinese medicine B are: 5-15 parts of Angelica sinensis, 5-15 parts of Carthamus tinctorius, 5 parts, Achyranthes bidentata 5-15 parts, Eupolyphaga sinensis 15-25 parts, Ligusticum chuanxiong 15-25 parts, Saposhnikovia divaricata 5-15 parts, Drynaria fortunei 40-60 parts, Frankincense 25-35 parts, Myrrh 25-35 parts, and Dried ginger 15-25 parts; the weight parts of each raw material in the traditional Chinese medicine C are respectively: Angelica sinensis 15-25 parts, Angelica dahurica 15-25 parts, Tangerine peel 15-25 parts, Citrus aurantium 40-60 parts, Cinnamon bark 5-15 parts, Atractylodes macrocephala 5-15 parts, Grape seeds 25-35 parts, and Astragalus membranaceus 5-15 parts.

[0009] Furthermore, the weight parts of each raw material in the traditional Chinese medicine A are: 100 parts of earthworm, 100 parts of scorpion, 30 parts of centipede, 100 parts of earthworm, 50 parts of processed arisaema, 50 parts of bombyx batryticatus, 50 parts of smilax glabra, 50 parts of safflower, 30 parts of xanthium sibiricum, 30 parts of processed Chuanwu, and 30 parts of processed Aconitum kusnezoffii; the weight parts of each raw material in the traditional Chinese medicine B are: 10 parts of angelica, 10 parts of safflower, 10 parts of Achyranthes bidentata, 20 parts of earthworm, 20 parts of Chuanxiong, 10 parts of siler, 50 parts of drynaria, 30 parts of frankincense, 30 parts of myrrh, and 20 parts of dried ginger; the weight parts of each raw material in the traditional Chinese medicine C are: 20 parts of angelica, 20 parts of angelica dahurica, 20 parts of dried tangerine peel, 50 parts of fructus aurantii, 10 parts of cinnamon bark, 10 parts of atractylodes macrocephala, 30 parts of grape seeds, and 10 parts of astragalus.

[0010] Furthermore, the sports-induced knee pain involves bone injury; the raw materials of the Chinese medicine B also include Dipsacus asper, Psoralea corylifolia, Panax notoginseng and Angelica dahurica; the raw materials of the Chinese medicine C also include Drynaria fortunei, Herba Lycopodii and Tripterygium wilfordii.

[0011] Among them, the added Dipsacus root in Traditional Chinese Medicine B is used to strengthen tendons and bones and promote callus formation; Psoralea corylifolia is used to promote calcium absorption and stimulate osteoblast activity; Panax notoginseng is used to reduce swelling and pain, improve local blood circulation, and reduce swelling after fractures; and Angelica dahurica is used to enhance the body's repair capacity. The added Drynaria fortunei in Traditional Chinese Medicine C is used to promote bone cell growth and calcium salt deposition; Gastrodia elata and Tripterygium wilfordii are used to relax tendons and improve circulation; Tripterygium wilfordii is also used to reduce swelling and relieve pain.

[0012] Furthermore, the weight portions of Dipsacus asper, Psoralea corylifolia, Panax notoginseng and Angelica dahurica in the traditional Chinese medicine B are respectively: 40-60 parts of Dipsacus asper, 40-60 parts of Psoralea corylifolia, 25-35 parts of Panax notoginseng and 5-15 parts of Angelica dahurica; the weight portions of Drynaria rhizome, Herba Lycopodii and Trichosanthis japonica in the traditional Chinese medicine C are respectively: 25-35 parts of Drynaria rhizome, 25-35 parts of Herba Lycopodii and 25-35 parts of Trichosanthis japonica.

[0013] Furthermore, the weight portions of Dipsacus asper, Psoralea corylifolia, Panax notoginseng and Angelica dahurica in the Chinese medicine B are respectively: 50 parts of Dipsacus asper, 50 parts of Psoralea corylifolia, 30 parts of Panax notoginseng and 10 parts of Angelica dahurica; the weight portions of Drynaria rhizome, Herba Lycopodii and Trichosanthis japonica in the Chinese medicine C are respectively: 30 parts of Drynaria rhizome, 30 parts of Herba Lycopodii and 30 parts of Trichosanthis japonica.

[0014] Furthermore, the Chinese medicine A is a medicinal wine, and the administration method is smearing; the Chinese medicine B is an ointment, and the administration method is external application; the Chinese medicine C is an essential oil, and the administration method is smearing.

[0015] In the second aspect, the present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition for treating sports-induced knee pain: The preparation method of the traditional Chinese medicine A is: all the raw materials are mixed and powdered, wrapped with gauze, and soaked in white wine to obtain the traditional Chinese medicine A; the preparation method of the traditional Chinese medicine B is: all the raw materials are ground into powder, and passed through an 80-100 mesh sieve; the powder is then made into a paste or mud through ginger, turmeric, etc., after blending evenly, and heated; after cooling to a temperature adapted to the human body, the traditional Chinese medicine B is obtained; the preparation method of the traditional Chinese medicine C is: all the raw materials are mixed and powdered, passed through a 20-40 mesh sieve, and the essential oil is extracted using supercritical carbon dioxide extraction technology to obtain the traditional Chinese medicine C.

[0016] Furthermore, in the preparation method of the traditional Chinese medicine A, the liquor is 50-60% pure grain-brewed liquor; the mass ratio of the earthworm to the liquor is 0.9-1.1:25, preferably 1:25; the soaking time is 20-40 days, preferably one month; in the preparation method of the traditional Chinese medicine B, the heating temperature is 95-105°C, preferably 100°C.

[0017] In a third aspect, the present invention also provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for treating sports-induced knee pain.

[0018] The beneficial effects of the present invention are as follows: the present invention provides a traditional Chinese medicine composition for treating sports-induced knee joint pain, which is composed of three traditional Chinese medicines, namely traditional Chinese medicine A, traditional Chinese medicine B and traditional Chinese medicine C, which are used in a coordinated manner. Hot compresses are applied externally to the sports knee joints, which can heat the affected joints or use heat to allow heat and its medicinal components to enter the body. The heat expands local blood vessels in the peripheral joints, reduces capillary resistance, increases microcirculation blood flow, relieves vascular smooth muscle spasms, warms the tendons and dredges the meridians, directly reaches the joints on the surface of the body, and penetrates the skin and bones to reach the lesions, thereby accelerating and timely relieving symptoms such as soreness, numbness, heaviness, stiffness, stiffness, and difficulty walking in the joints, with high efficacy and low recurrence rate.

[0019] Specifically, this invention utilizes a medicated wine (TCM A), an ointment (TCM B), and an essential oil (TCM C) to construct a three-stage transdermal treatment system. This system achieves multi-stage delivery through a sequential, coordinated administration model of "external application-heat compress-massage." In practice, the medicated wine (TCM A) is first applied to the affected area. The ethanol solvent in the wine dilates skin pores, promoting subsequent drug penetration. Subsequently, the ointment (TCM B) is heated and applied to the pretreated area. The thermal effect accelerates local blood circulation, allowing the blood-activating components of the wine to synergize with the meridian-warming and cold-dispelling components of the ointment, significantly enhancing drug bioavailability. Finally, a deep massage is performed using the essential oil of TCM C. Its small molecule terpenoids penetrate the epidermal barrier and reach the skin's surface. Simultaneously, the essential oil matrix forms a protective lipid film on the skin's surface, repairing micro-damage caused by the heat compress and prolonging drug retention. This three-dose system, through a gradient mechanism of "solvent-enhanced penetration-thermal conduction-targeted sustained release," creates a sustained, long-lasting drug release window, significantly improving therapeutic efficiency compared to a single dosage form. In addition, the present invention provides different formulas for different degrees of sports-induced knee pain. For sports-induced knee pain involving bone injury, Dipsacus asper, Psoralea corylifolia, Panax notoginseng and Angelica dahurica are added to Chinese medicine B, and Drynaria fortunei, Herba Lycopodii and Tripterygium wilfordii are added to Chinese medicine C, which enhance the body's repair ability, promote osteoblastic differentiation, reduce osteoclastic activity, and accelerate the formation of vascularized callus, having the dual advantages of promoting bone formation and inhibiting bone absorption. DETAILED DESCRIPTION

[0020] The present invention will be further described below with reference to specific embodiments.

[0021] Example 1

[0022] This embodiment provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A, traditional Chinese medicine B, and traditional Chinese medicine C. Traditional Chinese medicine A is prepared from the following ingredients: 100 g of Eupolyphaga sinensis, 100 g of Scorpio scorpion, 30 g of Scolopendra centipede, 100 g of Pheretima terrestris, 50 g of processed Arisaema, 50 g of Bombyx batryticatus, 50 g of Smilax glabra, 50 g of Carthamus tinctorius, 30 g of Xanthium sibiricum, 30 g of processed Chuanwu, and 30 g of processed Aconitum kusnezoffii. Traditional Chinese medicine B is prepared from the following ingredients: 10 g of Angelica sinensis, 10 g of Carthamus tinctorius, 10 g of Achyranthes bidentata, 20 g of Eupolyphaga sinensis, 20 g of Chuanxiong, 10 g of Saposhnikovia divaricata, 50 g of Drynaria fortunei, 30 g of frankincense, 30 g of Myrrha myrrh, and 20 g of dried ginger. Traditional Chinese medicine C is prepared from the following ingredients: 20 g of Angelica sinensis, 20 g of Angelica dahurica, 20 g of Tangerine peel, 50 g of Citrus aurantium, 10 g of Cinnamon bark, 10 g of Atractylodes macrocephala, 30 g of Grape seed, and 10 g of Astragalus membranaceus.

[0023] The preparation method of the traditional Chinese medicine composition is as follows: Traditional Chinese Medicine A: All raw materials are mixed and ground into a powder, wrapped in gauze, and soaked in 5 jin of white wine for one month. Traditional Chinese Medicine B: All raw materials are ground into a powder through an 80-100 mesh sieve. The powder is then blended with ginger and turmeric into a paste or slurry. After uniform mixing, the mixture is heated to 100°C and finally cooled to a temperature suitable for the human body. Traditional Chinese Medicine C: All raw materials are mixed and ground into a powder through a 20-40 mesh sieve. The essential oil is extracted using supercritical carbon dioxide extraction technology. Supercritical carbon dioxide extraction technology is existing technology and will not be described in detail.

[0024] The treatment method of the Chinese medicine composition is: apply Chinese medicine A to the affected area for about 5 minutes; then, apply Chinese medicine B to the area where Chinese medicine A is applied, fix it with plastic wrap, then put a dry towel into a steamer to heat it, then take it out and put it on Chinese medicine B for external application, then fix it with plastic wrap and use thermal insulation leather cloth to lock in the temperature, wait for about 40 minutes until the whole body sweats, then remove Chinese medicine B. If there is no sweat, continue to use the medicine for 1 hour and then remove it; after Chinese medicine B is removed, continue to apply Chinese medicine C to the area where Chinese medicine B is applied, massage and dredge it. At this time, through the hot compress of Chinese medicine B, a circulation promoter is created in the moving and static micro-capillaries, which helps the exchange of nutrients and gases between blood and organ cells, accelerates the elimination of toxic waste, and promotes muscle activity.

[0025] Example 2

[0026] This embodiment provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A, traditional Chinese medicine B, and traditional Chinese medicine C. Traditional Chinese medicine A is prepared from the following ingredients: 90 g of Eupolyphaga sinensis, 90 g of Scorpio scorpion, 20 g of Scolopendra centipede, 90 g of Pheretima terrestris, 40 g of processed Arisaema, 40 g of Bombyx batryticatus, 40 g of Smilax glabra, 40 g of Carthamus tinctorius, 20 g of Xanthium sibiricum, 20 g of processed Chuanwu, and 20 g of processed Aconitum kusnezoffii. Traditional Chinese medicine B is prepared from the following ingredients: 5 g of Angelica sinensis, 5 g of Carthamus tinctorius, 5 g of Achyranthes bidentata, 15 g of Eupolyphaga sinensis, 15 g of Chuanxiong, 5 g of Saposhnikovia divaricata, 40 g of Drynaria fortunei, 25 g of Frankincense, 25 g of Myrrha myrrh, and 15 g of dried ginger. Traditional Chinese medicine C is prepared from the following ingredients: 15 g of Angelica sinensis, 15 g of Angelica dahurica, 15 g of Tangerine peel, 40 g of Citrus aurantium, 5 g of Cinnamon bark, 5 g of Atractylodes macrocephala, 25 g of Grape seed, and 5 g of Astragalus membranaceus.

[0027] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0028] Example 3

[0029] This embodiment provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A, traditional Chinese medicine B, and traditional Chinese medicine C. Traditional Chinese medicine A is prepared from the following ingredients: 110 g of Eupolyphaga sinensis, 110 g of Scorpio scorpion, 40 g of Scolopendra centipede, 110 g of Pheretima terrestris, 60 g of processed Arisaema, 60 g of Bombyx batryticatus, 60 g of Rhizoma Smilacis Glabrae, 60 g of Carthamus tinctorius, 40 g of Fructus Xanthii, 40 g of processed Chuanwu (Aconiti Kusnezoffii), and 40 g of processed Aconitum kusnezoffii. Traditional Chinese medicine B is prepared from the following ingredients: 15 g of Angelica sinensis, 15 g of Carthamus tinctorius, 15 g of Achyranthes bidentata, 25 g of Eupolyphaga sinensis, 25 g of Chuanxiong, 15 g of Saposhnikovia divaricata, 60 g of Drynaria fortunei, 35 g of Frankincense, 35 g of Myrrha myrrh, and 25 g of dried ginger. Traditional Chinese medicine C is prepared from the following ingredients: 25 g of Angelica sinensis, 25 g of Angelica dahurica, 25 g of Tangerine peel, 60 g of Fructus Aurantii Immaturus, 15 g of Cinnamon bark, 15 g of Atractylodes macrocephala, 35 g of Grape seed, and 15 g of Astragalus membranaceus.

[0030] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0031] Example 4

[0032] This embodiment provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A, traditional Chinese medicine B, and traditional Chinese medicine C. Traditional Chinese medicine A is prepared from the following ingredients: 90 g of Eupolyphaga sinensis, 90 g of Scorpio scorpion, 20 g of Scolopendra centipede, 90 g of Pheretima terrestris, 40 g of processed Arisaema, 40 g of Bombyx batryticatus, 40 g of Rhizoma Smilacis Glabrae, 60 g of Carthamus tinctorius, 40 g of Xanthium sibiricum, 40 g of processed Chuanwu (Aconiti Lateralis Preparata), and 40 g of processed Aconitum kusnezoffii. Traditional Chinese medicine B is prepared from the following ingredients: 5 g of Angelica sinensis, 5 g of Carthamus tinctorius, 5 g of Achyranthes bidentata, 15 g of Eupolyphaga sinensis, 15 g of Chuanxiong (Rhizoma Chuanxiong), 15 g of Saposhnikovia divaricata, 60 g of Drynaria fortunei (Rhizoma Drynariae), 35 g of Frankincense, 35 g of Myrrha myrrh, and 25 g of Dried Zingiber officinale. Traditional Chinese medicine C is prepared from the following ingredients: 15 g of Angelica sinensis, 15 g of Angelica dahurica, 15 g of Tangerine peel, 60 g of Citrus aurantium, 15 g of Cinnamon bark, 15 g of Atractylodes macrocephala, 35 g of Grape seed, and 15 g of Astragalus membranaceus.

[0033] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0034] Example 5

[0035] This embodiment provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A, traditional Chinese medicine B, and traditional Chinese medicine C. Traditional Chinese medicine A is prepared from the following ingredients: 110 g of Eupolyphaga sinensis, 110 g of Scorpio scorpion, 40 g of Scolopendra centipede, 110 g of Pheretima terrestris, 60 g of processed Arisaema, 60 g of Bombyx batryticatus, 60 g of Smilax glabra, 40 g of Carthamus tinctorius, 20 g of Xanthium sibiricum, 20 g of processed Chuanwu, and 20 g of processed Aconitum kusnezoffii. Traditional Chinese medicine B is prepared from the following ingredients: 15 g of Angelica sinensis, 15 g of Carthamus tinctorius, 15 g of Achyranthes bidentata, 25 g of Eupolyphaga sinensis, 25 g of Chuanxiong, 5 g of Saposhnikovia divaricata, 40 g of Drynaria fortunei, 25 g of frankincense, 25 g of Myrrha myrrh, and 15 g of dried ginger. Traditional Chinese medicine C is prepared from the following ingredients: 25 g of Angelica sinensis, 25 g of Angelica dahurica, 25 g of Tangerine peel, 40 g of Citrus aurantium, 5 g of Cinnamon bark, 5 g of Atractylodes macrocephala, 25 g of Grape seed, and 5 g of Astragalus membranaceus.

[0036] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0037] Example 6

[0038] This embodiment provides a traditional Chinese medicine composition for treating sports-related knee joint pain associated with bone injury, comprising traditional Chinese medicine A, traditional Chinese medicine B, and traditional Chinese medicine C. Traditional Chinese medicine A is prepared from the following ingredients: 110 g of Eupolyphaga sinensis, 110 g of Scorpio scorpion, 40 g of Scolopendra centipede, 110 g of Pheretima terrestris, 60 g of processed Arisaema consanguineum, 60 g of Bombyx batryticatus, 60 g of Smilax glabra, 40 g of Carthamus tinctorius, 20 g of Xanthium sibiricum, 20 g of processed Chuanwu (Aconiti kusnezoffii), and 20 g of processed Aconitum kusnezoffii. Traditional Chinese medicine B is prepared from the following ingredients: 15 g of Angelica sinensis, 15 g of Carthamus tinctorius, 15 g of Achyranthes bidentata, 25 g of Eupolyphaga sinensis, 25 g of Chuanxiong (Ligusticum chuanxiong), 5 g of Saposhnikovia divaricata, 40 g of Drynaria fortunei, 25 g of Frankincense, 25 g of Myrrha myrrh, 15 g of Dried Ginger, 50 g of Dipsacus root, 50 g of Psoralea corylifolia, 30 g of Panax notoginseng, and 10 g of Angelica dahurica. Chinese medicine C was prepared from the following raw materials: 25 g of angelica sinensis, 25 g of angelica dahurica, 15 g of dried tangerine peel, 40 g of fructus aurantii, 5 g of cinnamon bark, 5 g of atractylodes macrocephala, 25 g of grape seed, 5 g of astragalus membranaceus, 30 g of drynariae, 30 g of scutellaria baicalensis, and 30 g of scutellaria baicalensis.

[0039] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0040] Comparative Example 1

[0041] This comparative example provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A and traditional Chinese medicine B. Traditional Chinese medicine A is prepared from the following ingredients: 100 g of Eupolyphaga sinensis, 100 g of Scorpio scorpion, 30 g of Scolopendra subspinipes, 100 g of Pheretima terrestris, 50 g of processed Arisaema consanguineum, 50 g of Bombyx batryticatus, 50 g of Smilax glabra, 50 g of Carthamus tinctorius, 30 g of Xanthium sibiricum, 30 g of processed Chuanwuji, and 30 g of processed Aconitum kusnezoffii. Traditional Chinese medicine B is prepared from the following ingredients: 10 g of Angelica sinensis, 10 g of Carthamus tinctorius, 10 g of Achyranthes bidentata, 20 g of Eupolyphaga sinensis, 20 g of Chuanxiong rhizome, 10 g of Saposhnikovia divaricata, 50 g of Drynaria fortunei, 30 g of Frankincense, 30 g of Myrrha myrrh, and 20 g of dried ginger.

[0042] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0043] Comparative Example 2

[0044] This comparative example provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine B and traditional Chinese medicine C. Traditional Chinese medicine B is prepared from the following ingredients: 10 g of Chinese Angelica sinensis, 10 g of Carthamus tinctorius, 10 g of Achyranthes bidentata, 20 g of Eupolyphaga sinensis, 20 g of Ligusticum chuanxiong, 10 g of Saposhnikovia divaricata, 50 g of Drynaria fortunei, 30 g of Frankincense, 30 g of Myrrha myrrh, and 20 g of dried ginger. Traditional Chinese medicine C is prepared from the following ingredients: 20 g of Chinese Angelica sinensis, 20 g of Angelica dahurica, 20 g of Tangerine peel, 50 g of Citrus aurantium, 10 g of Cinnamon bark, 10 g of Atractylodes macrocephala, 30 g of Grape seed, and 10 g of Astragalus membranaceus.

[0045] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0046] Comparative Example 3

[0047] This comparative example provides a traditional Chinese medicine composition for treating sports-induced knee pain, comprising traditional Chinese medicine A and traditional Chinese medicine C. Traditional Chinese medicine A is prepared from the following ingredients: 100 g of Eupolyphaga sinensis, 100 g of Scorpio scorpion, 30 g of Scolopendra centipede, 100 g of Pheretima terrestris, 50 g of processed Arisaema, 50 g of Bombyx batryticatus, 50 g of Smilax glabra, 50 g of Carthamus tinctorius, 30 g of Xanthium sibiricum fruit, 30 g of processed Chuanwu, and 30 g of processed Aconitum kusnezoffii. Traditional Chinese medicine C is prepared from the following ingredients: 20 g of Angelica sinensis, 20 g of Angelica dahurica, 20 g of Citrus reticulata peel, 50 g of Citrus aurantium, 10 g of Cinnamon bark, 10 g of Atractylodes macrocephala, 30 g of Grape seed, and 10 g of Astragalus membranaceus.

[0048] The preparation method and treatment method of the Chinese medicine composition are the same as those in Example 1.

[0049] Comparative Example 4

[0050] This comparative example provides a traditional Chinese medicine A for treating sports-induced knee pain, prepared from the following ingredients: 100 g of Eupolyphaga sinensis, 100 g of Scorpio scorpion, 30 g of Scolopendra centipede, 100 g of Pheretima lumbricoides, 50 g of processed Arisaema consanguineum, 50 g of Bombyx batryticatus, 50 g of Smilax glabra, 50 g of Carthamus tinctorius, 30 g of Xanthium sibiricum fruit, 30 g of processed Chuanwu (Aconiti Lateralis Preparata), and 30 g of processed Aconitum kusnezoffii. The preparation and treatment methods are the same as those in Example 1.

[0051] Comparative Example 5

[0052] This comparative example provides a Chinese medicine B for treating sports-induced knee pain, prepared from the following ingredients: 10 g of Angelica sinensis, 10 g of Carthamus tinctorius, 10 g of Achyranthes bidentata, 20 g of Eupolyphaga sinensis, 20 g of Ligusticum chuanxiong, 10 g of Saposhnikovia divaricata, 50 g of Drynaria fortunei, 30 g of Frankincense, 30 g of Myrrha myrrh, and 20 g of Dried Zingiber officinale. The preparation and treatment methods are the same as those in Example 1.

[0053] Comparative Example 6

[0054] This comparative example provides a Chinese medicine C for treating sports-induced knee pain, prepared from the following ingredients: 20 g of Chinese Angelica sinensis, 20 g of Angelica dahurica, 20 g of dried tangerine peel, 50 g of Citrus aurantium, 10 g of cinnamon bark, 10 g of Atractylodes macrocephala, 30 g of grape seed, and 10 g of Astragalus membranaceus. The preparation and treatment methods are the same as those in Example 1.

[0055] The therapeutic effect of the Chinese medicine composition of the present invention on sports-induced knee pain was verified through efficacy experiment 1 and efficacy experiment 2.

[0056] Efficacy experiment 1:

[0057] Patients with ligament injuries (sports-related knee pain without bone injury) who consulted Nanjing Yijingdao Medical Health Management Co., Ltd. were selected as test subjects. Clinical trials were conducted on 11 groups of ligament injury patients, each with 10 patients, using the traditional Chinese medicines of Examples 1 to 5 and Comparative Examples 1 to 6.

[0058] Eligibility criteria included complaints of sudden, sharp pain, joint swelling, and limited mobility; willingness to seek medical attention and participation in the trial. Dropout criteria included failure to complete the entire trial period due to subjective or objective reasons. By the end of the trial, 0 to 2 patients had dropped out of each group. The final data after excluding dropouts were used for this study. Basic information is shown in Table 1. Comparison of the general information among the 11 groups revealed no statistically significant differences (P > 0.05).

[0059] Table 1 Basic information of patients in each group of efficacy experiment 1

[0060]

[0061] The treatment methods of each group were the same as those of the embodiments / comparative examples, with a treatment frequency of once a day and a treatment time of one week.

[0062] Evaluation criteria include knee pain and knee range of motion. Knee pain is assessed using the visual analogue scale (VAS). Knee range of motion is measured using the triangle method. The patient's right leg (right dominant leg) is selected, with the lateral femoral condyle as the origin (A), and the greater trochanter (B) and lateral femoral condyle (C) forming a triangle. AB is side a, AC is side b, and BC is side c. The knee range of motion angle can be calculated using the trigonometric function formula and its corresponding inverse function formula: , measure the patient's active knee extension angle and contraction angle (that is, the patient moves by himself, the therapist only measures without intervention, eliminating the interference of differences in the therapist's intervention strength). The patient's extension angle is generally > contraction angle, and knee joint range of motion = active extension angle - active contraction angle.

[0063] Data Analysis: Paired-sample T-tests were used to compare the differences in knee pain and range of motion before and after treatment within each group. VAS scores before and after treatment are shown in Table 2, and the range of motion measured by the triangle method is shown in Table 3.

[0064] Table 2 VAS scores of each group before and after treatment in efficacy experiment 1

[0065] * : Significant at the P<0.05 level, ** : Significant at the P<0.01 level.

[0066] Table 3 Triangle method activity angles of each group before and after treatment in the efficacy experiment

[0067] * : Significant at the P<0.05 level, ** : Significant at the P<0.01 level.

[0068] As can be seen from Table 2 and Table 3, the pain intensity and joint mobility improvement degree of Examples 1 to 5 of the three kinds of Chinese medicine synergistic treatments before and after treatment all reach extremely significant levels, the pain intensity of the comparative examples 1 to 3 of the two kinds of Chinese medicine compound treatments before and after treatment reaches a relatively significant level, and the pain intensity difference of the comparative examples 4 to 6 of the single Chinese medicine treatment before and after treatment does not reach a significant level. Although the improvement of the knee joint mobility of the latter two classes of subjects reaches a significant level, from the perspective of mean value after treatment and before and after difference P value, the effect is not as good as the first class. Therefore, the present invention is coordinated by Chinese medicine A, Chinese medicine B and Chinese medicine C, and the heat of the external heating towel of Chinese medicine B expands the local blood vessels of the peripheral joints, reduces capillary resistance, increases microcirculation blood flow, relieves vascular smooth muscle spasm, warms the meridians and dredges the collaterals, makes the hands and feet meridians communicate, and the pores of the whole body are open, and the internal wind evil and cold dampness are discharged from the body with sweat. The combination of three traditional Chinese medicines for external treatment can make the effective ingredients of the drugs reach the joints and skin of the body surface and reach the lesions through the bones, so as to relax the muscles and tendons, promote qi circulation, activate blood circulation, eliminate blood stasis, dispel cold, remove evil and relieve pain, and can relieve the symptoms of rheumatoid arthritis in time.

[0069] Efficacy experiment 2:

[0070] Patients with bone contusion (sports-related knee pain involving bone injury) who consulted Nanjing Yijingdao Medical Health Management Co., Ltd. were selected as test subjects. Clinical trials were conducted on two groups of bone contusion patients using the Chinese medicines of Examples 1 and 6, respectively, with 10 patients in each group.

[0071] Eligibility criteria included complaints of deep, dull pain, pain that worsens at rest and at night, weight-bearing limitations, and limited mobility; patients actively sought medical attention and were willing to participate in the trial. Dropout criteria included failure to complete the entire trial period due to subjective or objective reasons. By the end of the trial, 0 to 1 patient had dropped out of each group. The final data after excluding dropouts were used for this study. Basic information is shown in Table 4. Comparison of general information between the two groups revealed no statistically significant differences (P > 0.05).

[0072] Table 4 Basic information of patients in each group of efficacy experiment 2

[0073] The treatment methods for each group were the same as those in the examples, with a treatment frequency of once a day and a treatment duration of one week.

[0074] Evaluation indicators and data analysis were the same as those in efficacy experiment 1. The VAS scores of each group before and after treatment are shown in Table 5, and the activity angles of the triangle method are shown in Table 6.

[0075] Table 5 VAS scores of each group before and after treatment in efficacy experiment 2

[0076] *: Significant at the P<0.05 level, ** : Significant at the P<0.01 level.

[0077] Table 6 Triangle method activity angles of each group before and after treatment in efficacy experiment 2

[0078] * : Significant at the P<0.05 level, ** : Significant at the P<0.01 level.

[0079] As can be seen from Tables 5 and 6, for sports-induced knee pain involving bone injury, the addition of Dipsacus asper, Psoralea corylifolia, Panax notoginseng and Angelica dahurica to Chinese medicine B, and the addition of Drynaria fortunei, Cyperus rotundus and Tripterygium wilfordii to Chinese medicine C can bidirectionally promote osteoblast activity and inhibit osteoclast differentiation, accelerate the maturation of vascularized callus, and achieve a dynamic balance between promoting bone formation and inhibiting bone resorption.

[0080] Typical case 1:

[0081] A patient complained of knee valgus caused by sports sprain, which was mainly manifested by local pain and swelling, specifically qi stagnation and blood stasis syndrome, with swelling and pain in the knee after injury, ecchymosis, flexion and extension disorders, dark tongue with ecchymosis, and stringy pulse. Therefore, traditional Chinese medicine diagnosed it as tendon injury or tendon arthritis, and Western medicine diagnosed it as knee collateral ligament injury, which required blood circulation and blood stasis, swelling and analgesia treatment. The Chinese medicine composition and its treatment method of Example 1 were used for treatment, with a treatment frequency of 1 time / day and a treatment time of 1 week. After treatment, the pain and swelling disappeared and the flexion and extension angles improved.

[0082] Typical Case 2:

[0083] B patient's main complaint: knee joint rotation injury during exercise, mainly manifested as pain, swelling, joint snapping, locking, etc., specifically as Qi stagnation and blood stasis syndrome, severe knee pain after injury, obvious swelling, frequent locking, dark red tongue with ecchymosis, and stringy and astringent pulse. Thus, the traditional Chinese medicine diagnosis is tendon injury, knee arthritis or arthritis, and the Western medicine diagnosis is meniscus injury, which requires blood circulation and blood stasis removal, qi circulation and pain relief treatment. The Chinese medicine composition and its treatment method of embodiment 6 are used for treatment, with a treatment frequency of 1 time / day and a treatment time of 1 week. After treatment, pain and swelling are alleviated, and locking symptoms are alleviated.

[0084] In the present invention, unless otherwise specified, the scientific and technical terms used herein have the meanings commonly understood by those skilled in the art. In addition, the reagents, materials and operating procedures used herein are those widely used in the corresponding fields.

[0085] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating sports-induced knee pain, characterized in that: Including Chinese medicine A, Chinese medicine B and Chinese medicine C; The raw materials of the Chinese medicine A include: Eupolyphaga sinensis, Scorpio scorpion, Centipede, Earthworm, processed Arisaema, Bombyx batryticatus, Smilax glabra, Carthamus tinctorius, Xanthium sibiricum, processed Chuanwu and processed Kusnezoffii; The raw materials of the Chinese medicine B include: angelica, safflower, cyperus, ground beetle, chuanxiong, siler, drynaria, frankincense, myrrh and dried ginger; The raw materials of the traditional Chinese medicine C include: angelica sinensis, angelica dahurica, dried tangerine peel, fructus aurantii, cinnamon bark, atractylodes macrocephala, grape seed and astragalus root.

2. The Chinese medicine composition for treating sports-induced knee pain according to claim 1, characterized in that: The weight parts of the raw materials in the Chinese medicine A are as follows: 90-110 parts of Eupolyphaga sinensis, 90-110 parts of Scorpio scorpion, 20-40 parts of Scolopendra centipede, 90-110 parts of Pheretima terrestris, 40-60 parts of processed Arisaema, 40-60 parts of Bombyx batryticatus, 40-60 parts of Smilax glabra, 40-60 parts of Carthamus tinctorius, 20-40 parts of Xanthium sibiricum fruit, 20-40 parts of processed Chuanwu, and 20-40 parts of processed Kusnezoffius kusnezoffii. The weight parts of the raw materials in the Chinese medicine B are as follows: 5-15 parts of angelica, 5-15 parts of safflower, 5-15 parts of cyperus, 15-25 parts of earthworm, 15-25 parts of ligusticum, 5-15 parts of siler, 40-60 parts of drynaria, 25-35 parts of frankincense, 25-35 parts of myrrh, and 15-25 parts of dried ginger; The weight portions of the raw materials in the traditional Chinese medicine C are: 15-25 parts of angelica sinensis, 15-25 parts of angelica dahurica, 15-25 parts of dried tangerine peel, 40-60 parts of fructus aurantii, 5-15 parts of cinnamon bark, 5-15 parts of atractylodes macrocephala, 25-35 parts of grape seeds, and 5-15 parts of astragalus.

3. The Chinese medicine composition for treating sports-induced knee pain according to claim 1, characterized in that: The weight parts of the raw materials in the Chinese medicine A are as follows: 100 parts of Eupolyphaga sinensis, 100 parts of Scorpio, 30 parts of Scolopendra, 100 parts of Pheretima, 50 parts of processed Arisaema, 50 parts of Bombyx Batryticatus, 50 parts of Smilax glabra, 50 parts of Carthamus tinctorius, 30 parts of Xanthium sibiricum, 30 parts of processed Chuanwu, and 30 parts of processed Kusnezoffii. The weight parts of the raw materials in the Chinese medicine B are as follows: 10 parts of angelica, 10 parts of safflower, 10 parts of cyperus, 20 parts of ground beetle, 20 parts of ligusticum, 10 parts of siler, 50 parts of rhizome of drynaria, 30 parts of frankincense, 30 parts of myrrh, and 20 parts of dried ginger; The weight proportions of the raw materials in the Chinese medicine C are: 20 parts of angelica sinensis, 20 parts of angelica dahurica, 20 parts of dried tangerine peel, 50 parts of fructus aurantii, 10 parts of cinnamon bark, 10 parts of atractylodes macrocephala, 30 parts of grape seeds and 10 parts of astragalus.

4. The Chinese medicine composition for treating sports-induced knee pain according to claim 1, characterized in that: The sports-induced knee pain involves bone damage; The raw materials of the Chinese medicine B also include Dipsacus asper, Psoralea corylifolia, Panax notoginseng and Angelica dahurica; The raw materials of the Chinese medicine C also include Drynaria fortunei, Herba Lycopodii and Tripterygium wilfordii.

5. The Chinese medicine composition for treating sports-induced knee pain according to claim 4, characterized in that: The weight portions of Dipsacus root, Psoralea corylifolia, Panax notoginseng and Angelica dahurica in the Chinese medicine B are respectively: 40-60 parts of Dipsacus root, 40-60 parts of Psoralea corylifolia, 25-35 parts of Panax notoginseng and 5-15 parts of Angelica dahurica; The weight proportions of Rhizoma Drynariae, Herba Achyranthis Bidentatae and Herba Dioscoreae in the Chinese medicine C are respectively: 25-35 parts of Rhizoma Drynariae, 25-35 parts of Herba Achyranthis Bidentatae and 25-35 parts of Herba Dioscoreae.

6. The Chinese medicine composition for treating sports-induced knee pain according to claim 4, characterized in that: The weight portions of Dipsacus root, Psoralea corylifolia, Panax notoginseng and Angelica dahurica in the Chinese medicine B are respectively: 50 parts of Dipsacus root, 50 parts of Psoralea corylifolia, 30 parts of Panax notoginseng and 10 parts of Angelica dahurica; The weight proportions of Drynaria rhizome, Herba Achyranthis Bidentatae and Herba Dioscoreae in the Chinese medicine C are respectively: 30 parts of Drynaria rhizome, 30 parts of Herba Achyranthis Bidentatae and 30 parts of Herba Dioscoreae.

7. The Chinese medicine composition for treating sports-induced knee pain according to claim 1, characterized in that: The Chinese medicine A is a medicinal wine, and the administration method is smear administration; The Chinese medicine B is an ointment and is administered by external application; The Chinese medicine C is essential oil, and the administration method is smear administration.

8. The method for preparing the Chinese medicine composition for treating sports-induced knee pain according to any one of claims 1 to 7, wherein: The preparation method of the Chinese medicine A is as follows: all raw materials are mixed and powdered, wrapped with gauze, and soaked in white wine to obtain the Chinese medicine A; The preparation method of the Chinese medicine B is as follows: grinding all raw materials into powder; then making the powder into a paste or mud, blending it evenly, and heating it; After cooling to a temperature adapted to the human body, the Chinese medicine B is obtained; The preparation method of the Chinese medicine C is as follows: all raw materials are mixed and powdered, and essential oil is extracted by supercritical carbon dioxide extraction technology to obtain the Chinese medicine C.

9. The method for preparing the Chinese medicine composition for treating sports-induced knee pain according to claim 6, characterized in that: In the preparation method of the Chinese medicine A, the liquor is a liquor brewed from pure grains with an alcohol content of 50 to 60%; The mass ratio of ground beetle to liquor is 0.9-1.1:25; the soaking time is 20-40 days; In the preparation method of the traditional Chinese medicine B, the heating temperature is 95-105°C.

10. Use of the traditional Chinese medicine composition according to any one of claims 1 to 7 in the preparation of a medicament for treating sports-induced knee pain.

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