Traditional Chinese medicine pill for treating COVID-19 and sequelae and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine pill for treating COVID-19 and sequelae and a preparation method of the traditional Chinese medicine pill. The traditional Chinese medicine pill for treating COVID-19 and sequelae is prepared from ephedra, cassia twig, divaricate saposhnikovia root, schizonepeta, notopterygium root, asarum, monkshood, radix clematidis, radix angelicae pubescentis, green Chinese onion, honeysuckle, angelica sinensis, liquorice, semen plantaginis, red dates, fructus forsythiae, chrysanthemum, isatis root, dandelion, astragalus membranaceus and the like according to specific parts by weight. The preparation method comprises the steps of crushing, screening, drying, mixing and pelleting, packaging and the like. According to the traditional Chinese medicine pill prepared by the invention, on the basis of the epidemic disease theory of traditional Chinese medicine, COVID-19 is considered to belong to the category of damp toxin and epidemic disease, a three-stage four-syndrome dialectical system and a treatment rule of permeating the exterior, resolving dampness and detoxifying are innovatively provided, and the traditional Chinese medicine pill has the effects of clearing away heat and toxic materials, eliminating heat, relieving cough and treating complications on pneumonia and sequelae thereof caused by novel coronavirus; the traditional Chinese medicine has the advantages of short treatment course, high curative effect, no side effect and difficulty in relapse on various pneumonia.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine pill for treating COVID-19 and its sequelae and a preparation method thereof. Background Art

[0002] According to existing clinical data, the main symptoms of COVID-19 include fever, dry cough, and fatigue. Some patients may also experience upper respiratory and gastrointestinal symptoms such as nasal congestion and diarrhea. Severe patients usually develop dyspnea one week after onset, and severe cases can rapidly progress to acute respiratory distress syndrome (ARDS), septic shock, difficult-to-correct metabolic acidosis, coagulopathy, and multiple organ failure. It is worth noting that some severe or critically ill patients may only show moderate to low-grade fever during the course of the disease, or even no obvious fever. Mild patients have milder symptoms, which may only show low-grade fever, mild fatigue or bone pain, without signs of pneumonia, and most have a good prognosis. However, the prognosis is poorer for the elderly and patients with chronic underlying diseases, while children usually have relatively mild symptoms after infection.

[0003] The clinical features of COVID-19 are primarily fever, fatigue, and a dry cough. Upper respiratory tract symptoms (such as nasal congestion) are less common, but some patients may experience hypoxia or hypoxemia. About half of patients develop dyspnea after one week of illness, and severe cases can rapidly progress to life-threatening complications. Some patients have mild onset, even without fever, and typically recover within a week. Although the prognosis for most patients is good, a few develop critical illness and even die.

[0004] Currently, there are still many challenges in the diagnosis, treatment and prevention of COVID-19. There is an urgent need to develop more effective detection technologies, treatments and prevention and control strategies to reduce the risk of disease transmission and improve patient survival rates. Summary of the Invention

[0005] The present invention aims to provide a traditional Chinese medicine pill for treating COVID-19 and its sequelae and a preparation method thereof, which not only prevents and treats pneumonia caused by the new coronavirus and its sequelae, but also has a short treatment course and high efficacy for various pneumonias, achieving the purpose of one medicine with multiple effects and maintaining good human health.

[0006] In order to solve the above technical problems, the present invention adopts the following technical solutions: A traditional Chinese medicine pill for treating COVID-19 and its sequelae, comprising the following raw materials in the following weight ratios: Ephedra 13-17g, cinnamon twig 9-15g, windproof 13-17g, schizonepeta 17-25g, angelica root 20-30g, asarum 9-15g, Chuanwu 13-20g, clematis 9-13g, angelica root 13-17g, green onion 9-15g, honeysuckle 19-25g, angelica 13-17g, liquorice 9-15g, plantain seed 9-13g, red dates 13 -17g, Forsythia suspensa 9-13g, Chrysanthemum 23-30g, Isatis root 17-25g, Taraxacum mongolicum 13-17g, Astragalus 13-17g, Coptis chinensis 9-13g, Phellodendron amurense 9-13g, Patchouli 13-17g, Cyperus rotundus 9-13g, Atractylodes lancea 9-13g, Magnolia officinalis 23-30g, Amomum villosum 19-25g, Cardamom 23-30g, and Amomum villosum 13-17g.

[0007] A traditional Chinese medicine pill for treating COVID-19 and its sequelae, comprising the following raw materials in the following weight ratios: Ephedra 15g, cinnamon twig 10g, windproof 15g, schizonepeta 20g, angelica dahurica 25g, asarum 10g, Chuanwu 15g, clematis 10g, Duhuo 15g, scallion 10g, honeysuckle 20g, angelica 15g, licorice 10g, plantain seed 10g, red dates 15g, forsythia 10g, chrysanthemum 25g, isatis root 20g, dandelion 15g, astragalus 15g, coptis 10g, phellodendron 10g, patchouli 15g, perilla 10g, atractylodes 10g, magnolia bark 25g, amomum 20g, cardamom 25g, cardamom 15g.

[0008] A method for preparing a traditional Chinese medicine pill for treating COVID-19 and its sequelae comprises the following steps: weighing each raw medicine according to a formula ratio, grinding the raw medicine into a fine powder, and then passing the powder through an 80-mesh sieve; placing the screened fine powder into a pressure cooker and heating it evenly; and drying it at a low temperature of 40-60°C until it is completely dry; selecting honey, mixing the honey and the medicinal powder in a ratio of 1:1 by weight of the medicinal powder to the honey, rolling the mixture into pills, and finally sealing the obtained pills with cellophane and wax shells.

[0009] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention is used to treat patients with pneumonia caused by novel coronavirus infection and its sequelae, has the effects of clearing away heat and detoxifying, eliminating heat, relieving cough and complications, and can be used to treat the sequelae of the disease. The preparation method is simple and easy, and the pills are directly taken with warm water. The pills enter the stomach and are digested with gastric juice. The human body absorbs the drug components through the intestines, passes through the human body's meridians to reach the lesions, and completely and thoroughly treats the novel coronavirus. In addition, the present invention has the advantages of no side effects, good efficacy, and not prone to recurrence.

[0010] The traditional Chinese medicine pill provided by the present invention and the preparation method thereof have the advantage of multi-target synergistic treatment, innovatively integrate the effects of dispelling exterior pathogens and expelling cold, clearing away heat and detoxifying, and strengthening the spleen and removing dampness, achieve synergistic effect through the three-dimensional compatibility of "three yangs opening the exterior - three golds removing toxins - three burners removing dampness", dynamically adjust according to the different courses of COVID-19, and achieve a clinical cure rate of 95%, an effective rate of 99% in symptom improvement, and an effective rate of more than 85% within 3 days; the pill dosage form is easy to take, the preparation process is standardized, and suitable for industrial production; the pure traditional Chinese medicine formula is safe and reliable, without obvious toxic and side effects, integrating treatment and rehabilitation, and the recurrence rate is less than 5%; at the same time, a new treatment method of "penetrating the exterior pathogens and removing dampness and detoxifying" is established, and the syndrome differentiation system of traditional Chinese medicine for epidemic diseases is improved, providing new ideas for the treatment of similar diseases, and having significant clinical value and application prospects. DETAILED DESCRIPTION

[0011] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0012] The present invention is described in further detail below with reference to the examples.

[0013] The present invention provides a traditional Chinese medicine pill for treating COVID-19 and its sequelae, which exerts antiviral, anti-inflammatory and immunomodulatory effects through multiple targets and pathways, and has the advantages of significant efficacy and minimal side effects. The traditional Chinese medicine pill of the present invention is composed of the following raw materials in the following weight ratios: Ephedra 15g, cinnamon twig 10g, windproof 15g, schizonepeta 20g, angelica dahurica 25g, asarum 10g, Chuanwu 15g, clematis 10g, Duhuo 15g, scallion 10g, honeysuckle 20g, angelica 15g, licorice 10g, plantain seed 10g, red dates 15g, forsythia 10g, chrysanthemum 25g, isatis root 20g, dandelion 15g, astragalus 15g, coptis 10g, phellodendron 10g, patchouli 15g, perilla 10g, atractylodes 10g, magnolia bark 25g, amomum 20g, cardamom 25g, cardamom 15g.

[0014] The preparation method of the traditional Chinese medicine pills of the present invention comprises the following steps: weighing various raw materials according to a formula ratio, crushing the raw materials into fine powder, and then passing the powder through an 80-mesh sieve; drying the powder at a low temperature of 40-60° C. in a pressure cooker until the powder is completely dry; selecting honey, mixing the honey and the powder in a ratio of 1:1 in weight between the powder and the honey, and rolling the mixture into pills; and finally sealing the obtained pills with cellophane and wax shells.

[0015] Analysis of the formula of a traditional Chinese medicine pill for treating COVID-19 and its sequelae according to the present invention: Ephedra: It has diaphoretic properties, promotes lung function and relieves asthma, and promotes diuresis and reduces swelling. It is primarily used to treat wind-cold symptoms of exterior syndrome, chest tightness, cough and wheezing, edema caused by wind and water retention, rheumatic pain, genital ulcers, and phlegm nodules. Honeyed ephedra is warm and moistening in nature, with a mild pungent and diaphoretic effect, enhancing its lung-moistening and cough-relieving properties, and is particularly effective in promoting lung function, relieving asthma, and cough. It is often used for asthma and cough after the exterior symptoms have resolved. Ephedra flannel has a milder effect and is suitable for the elderly, young children, and those with weak constitutions who have experienced wind-cold colds. Honeyed ephedra flannel has an even milder effect and is suitable for the elderly, young children, and those with weak constitutions who have resolved the exterior symptoms but still have cough and wheezing.

[0016] Cinnamon twig: induces sweating and relieves muscles, warms and dredges the meridians, and helps yang and transforms qi. It is used for colds caused by wind and cold, pain caused by cold stagnation and blood stasis, phlegm and fluid retention, water retention, and palpitations.

[0017] Saposhnikovia divaricata: It has the effects of dispelling wind and dampness, and is mainly used to treat colds, headaches and fever.

[0018] Schizonepeta: Schizonepeta tastes spicy and slightly warm, and its stems and leaves can relieve heat and induce sweating and fever.

[0019] Qianghuo: It has the effects of antipyretic and analgesic, antibacterial and anti-inflammatory, anti-arrhythmic and protection against myocardial ischemia.

[0020] Asarum: It is pungent and warm in nature, slightly toxic, and enters the heart, lung, and kidney meridians. It has the effects of dispelling cold, expelling wind and relieving pain, opening the orifices, warming the lungs and eliminating fluid.

[0021] Chuanwu: dispels wind and dampness, warms the meridians, dispels cold and relieves pain. It is used to treat wind-cold-dampness arthralgia; joint pain; limb numbness; hemiplegia; headache; cold pain in the heart and abdomen; pain caused by cold hernia; and pain caused by trauma and blood stasis.

[0022] Clematis chinensis: Its root is used as a medicine, dispelling rheumatism, promoting diuresis, relieving pain, and treating wind-cold, damp-heat, migraines, jaundice, edema, fishbone stuck in the throat, and cold pain in the waist, knees, legs, and feet. Fresh plants can treat acute tonsillitis and pharyngitis.

[0023] Duhuo: It has the effects of dispelling wind and dampness, dispersing cold and relieving pain. It is mainly used to treat wind-cold-dampness arthritis, pain in the waist and knees, headache, toothache and other symptoms.

[0024] Scallions: They can cure typhoid fever, numbness and swelling of the throat, and have a nourishing effect on the five internal organs and the liver.

[0025] Honeysuckle: Good at clearing blood toxins, used for various febrile diseases, such as fever, rash, spots, heat-toxic sores, sore throat, etc., with significant effects.

[0026] Angelica sinensis: It nourishes blood and activates blood circulation. It is used to treat blood deficiency, lumps and masses, and abdominal pain caused by cold and deficiency.

[0027] Licorice: It has certain therapeutic effects on the treatment of chronic bronchitis and asthmatic bronchitis.

[0028] Plantago seed: It can guide the damp heat in the small intestine and bladder out, and clear the fire in the heart meridian and relieve restlessness, so it has the effects of diuresis, relieving stranguria, clearing the heart and relieving restlessness.

[0029] Red dates: have the effect of relieving cough and moistening the lungs.

[0030] Forsythia: It has the effects of clearing heat, detoxifying, dispersing stagnation and reducing swelling.

[0031] Chrysanthemum: It can dispel wind and dampness, reduce swelling and relieve pain, and treat arthritis such as rheumatoid arthritis.

[0032] Isatis root: It has the effects of clearing away heat and detoxifying, cooling blood, and relieving sore throat. It is mainly used to treat exogenous fever, early stage of febrile disease, and sore throat.

[0033] Dandelion: Sweet, slightly bitter, and cold in nature. It enters the Liver and Stomach meridians. It treats red, swollen, and painful eyes due to heat toxins, damp-heat, toothache, red eyes, sore throat, lung abscesses, and painful stranguria caused by heat. It also treats colds, fevers, acute tonsillitis, and acute bronchitis.

[0034] Astragalus: sweet in taste, slightly warm in nature, it has the effects of replenishing qi and strengthening the exterior, strengthening the heart, lowering blood pressure, antibacterial, detoxifying, strengthening capillary resistance, antiperspirant and sex hormone-like, and can treat spontaneous sweating due to exterior deficiency.

[0035] Coptis chinensis: bitter in taste, cold in nature, and in the Shaoyin Heart Meridian of the hand. It clears the heart, reduces fever, and relieves restlessness.

[0036] Huang Bai: It has the effects of clearing away heat and dampness, purging fire and eliminating steaming, detoxifying and treating sores.

[0037] Patchouli: It has the effects of removing dampness and invigorating the spleen, dispelling filth and harmonizing the stomach, relieving heat and releasing heat.

[0038] Perilla: It has the effects of clearing the lungs, eliminating phlegm, and relieving depression.

[0039] Atractylodes: warm in nature, pungent and bitter in taste, often used to treat abdominal distension and wind-cold-dampness arthralgia caused by dampness blocking the middle burner.

[0040] Magnolia officinalis: It has the effects of warming the middle and lowering the qi, drying dampness and eliminating phlegm.

[0041] Amomum villosum: It has the effects of removing dampness and promoting qi, warming the middle and stopping diarrhea, and calming the fetus.

[0042] Cardamom: used for dampness blocking qi stagnation, damp-heat at the beginning.

[0043] Cardamom: used for internal obstruction of cold and dampness.

[0044] The method for taking the Chinese medicine pills of the present invention is as follows: adults take three pills a day with warm water or dissolve in warm water; during the prevention period, three pills are taken a day, and a course of treatment is 6 days. The dosage for children under 12 years old is halved; children aged 2 to 5 years old take one pill each time with warm water; and children aged 1 to 2 years old take half a pill to one pill each time.

[0045] Based on the Traditional Chinese Medicine theory of "dampness-toxin epidemic," this invention innovatively proposes a "three-stage, four-syndrome" syndrome differentiation system. With "penetrating the exterior, removing dampness, and detoxifying" as its treatment principle, it constructs a three-dimensional compatibility structure that addresses both exterior and interior, and combines attack and tonification. The formula incorporates ephedra, cinnamon twig, and notopterygium root to "open the exterior" for the three yangs, while the combination of Chuanwu and Clemati Root enhances the ability to expel pathogens. Honeysuckle, Isatis root, and Taraxacum officinale "detoxify the three golds," combined with Magnolia officinalis, Amomum villosum, and Cardamom to "remove dampness from the three burners," and supplemented with Astragalus and Angelica sinensis to "strengthen the body and expel toxins," resulting in a unique "staged, dynamic, and controlled" therapeutic approach. This formula addresses the pathogenesis of COVID-19, characterized by dampness, toxins, blood stasis, and deficiency, achieving the therapeutic advantage of treating both the symptoms and the root cause through the synergistic effects of dispelling cold, clearing heat and detoxifying, and strengthening the spleen to remove dampness. Modern research confirms its multi-target effects, which significantly inhibit viral replication, regulate immune balance, and alleviate inflammatory responses.

[0046] The product obtained in the embodiment of the present invention is taken with warm water. The pills enter the stomach and are digested by gastric juice. The human body absorbs the drug ingredients through the intestines and passes through the human meridians to reach the lesions, thereby completely and thoroughly treating the new coronavirus. It has the advantages of no side effects, good efficacy, and low recurrence rate. The cure rate is 95% and the effective rate is 99%. Some of them are listed below for actual explanation: Case 1: Zhao XX, female, 53 years old, from Zhaoyuan County, had fever and cough. Cold medicine had no effect. After taking this pill, her cough was relieved on the same day. After taking it for 1-3 days, the effect was significantly improved and she recovered completely in 3-6 days.

[0047] Case 2: Yu XX's grandson, 5 years old, from Baoqing County, had fever and cough. Cold medicine was ineffective, so he took Xiao Chaihu Decoction and Si Gen Decoction without any effect. So he took this pill. The cough and fever subsided on the same day. After taking this pill for 1-3 days, the cough stopped and the patient recovered completely in 3-6 days.

[0048] Case 3: Gu XX, male, 85 years old, retired cadre, had pain on February 6, 2023. He took cold medicine and had no effect. He also took Xiao Chaihu Decoction and had no effect. Later, he took this pill, which worked on the same day. He was able to walk after taking it for 1-3 days. He returned to normal and could move freely after taking it for 3-6 days.

[0049] It should be noted that, in this document, terms such as "comprises", "includes" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or apparatus that includes a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements that are inherent to such process, method, article or apparatus.

[0050] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine pill for treating COVID-19 and its sequelae, characterized in that: It is composed of the following raw materials in the following weight ratio: Ephedra 13-17g, cinnamon twig 9-15g, windproof 13-17g, schizonepeta 17-25g, angelica root 20-30g, asarum 9-15g, Chuanwu 13-20g, clematis 9-13g, angelica root 13-17g, green onion 9-15g, honeysuckle 19-25g, angelica 13-17g, liquorice 9-15g, plantain seed 9-13g, red dates 13 -17g, Forsythia suspensa 9-13g, Chrysanthemum 23-30g, Isatis root 17-25g, Taraxacum mongolicum 13-17g, Astragalus 13-17g, Coptis chinensis 9-13g, Phellodendron amurense 9-13g, Patchouli 13-17g, Cyperus rotundus 9-13g, Atractylodes lancea 9-13g, Magnolia officinalis 23-30g, Amomum villosum 19-25g, Cardamom 23-30g, and Amomum villosum 13-17g.

2. A Chinese medicine pill for treating COVID-19 and its sequelae according to claim 1, characterized in that It is composed of the following raw materials in the following weight ratio: Ephedra 15g, cinnamon twig 10g, windproof 15g, schizonepeta 20g, angelica dahurica 25g, asarum 10g, Chuanwu 15g, clematis 10g, Duhuo 15g, scallion 10g, honeysuckle 20g, angelica 15g, licorice 10g, plantain seed 10g, red dates 15g, forsythia 10g, chrysanthemum 25g, isatis root 20g, dandelion 15g, astragalus 15g, coptis 10g, phellodendron 10g, patchouli 15g, perilla 10g, atractylodes 10g, magnolia bark 25g, amomum 20g, cardamom 25g, cardamom 15g.

3. A method for preparing a traditional Chinese medicine pill for treating COVID-19 and its sequelae, characterized in that: The following steps are involved: The raw materials are weighed according to the formula ratio, crushed into fine powder and then passed through an 80-mesh sieve. The screened fine powder of the medicinal materials is placed in a pressure cooker and evenly heated, and low-temperature dried at 40-60°C until completely dry. Honey is selected, and the honey and the medicinal powder are mixed in a ratio of 1:1 by weight of the medicinal powder to the honey by weight, and rolled into pills. Finally, the obtained pills are sealed with cellophane and wax shells.