Health-care spray for relieving shoulder, neck, waist and leg pain and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a health-care spray for relieving shoulder, neck, waist and leg pain and a preparation method thereof. The health-care spray is prepared from the following raw materials in parts by weight: 10 to 20 parts of unprocessed radix aconiti, 10 to 20 parts of unprocessed radix aconiti kusnezoffii, 10 to 20 parts of unprocessed rhizoma arisaematis, 10 to 20 parts of unprocessed rhizoma pinelliae, 10 to 20 parts of herba asari, 5 to 15 parts of unprocessed semen strychni, 10 to 20 parts of herba artemisiae rupestris, 10 to 20 parts of pericarpium zanthoxyli, 10 to 20 parts of fructus crataegi, 80 to 100 parts of rhizoma zingiberis recens, 80 to 100 parts of dried fragrant-flowered garlic, 80 to 100 parts of phoenix tree root bark and 80 to 100 parts of camphor. The method has the beneficial effects that the safety is remarkably improved: the anti-allergic agent dipotassium glycyrrhizinate reduces the occurrence rate of skin irritation from 90% of a traditional formula to 10% by inhibiting the release of histamine, and the score of erythema / edema is only 0.5 (2.8 of a traditional group); a transdermal enhancer azone enhances the flowability of cuticle, so that the onset time of the medicine is shortened to 12.3 minutes (25.5 minutes of a traditional group) and is close to that of a chemical medicine ibuprofen (10.2 minutes);

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, in particular to a health-care spray for relieving pain in shoulders, neck, waist and legs and a preparation method thereof. Background Art

[0002] Traditional Chinese medicine external treatments are widely used in relieving pain in the shoulders, neck, waist and legs. Among them, the pure wine soaking method is adopted because of its simple operation, low cost and good pain relief effect.

[0003] However, the existing technology has the following significant defects:

[0004] Low extraction efficiency: Traditional single-solvent immersion methods (such as high-concentration ethanol) cannot simultaneously extract both fat-soluble and water-soluble components, resulting in a high loss of active ingredients. For example, the coexistence of aconitine (fat-soluble) and flavonoids (water-soluble) can easily reduce the extraction rate due to solvent polarity mismatch;

[0005] Strong irritation: Raw Chuanwu and raw Caowu contain diester alkaloids, which can easily cause adverse reactions such as skin erythema and edema when directly soaked. Literature reports that the incidence of irritation is as high as 80%-90%;

[0006] Slow onset of effect: Traditional formulas have low transdermal absorption efficiency, and drugs have difficulty penetrating the stratum corneum quickly. Clinical trials have shown that the onset time is generally more than 20 minutes.

[0007] In response to the above problems, the present invention proposes a health spray for relieving shoulder, neck, waist and leg pain and its preparation method to solve the above problems through a segmented extraction process, a compound of a transdermal enhancer and an anti-allergic agent, and an auxiliary technology of crushing traditional Chinese medicine to extract ingredients. Summary of the Invention

[0008] In view of the problems existing in the prior art, the present invention discloses a health-care spray for relieving shoulder, neck, waist and leg pain and a preparation method thereof. The technical scheme adopted is that the health-care spray is composed of the following raw materials in parts by weight: 10-20 parts of raw Chuanwu, 10-20 parts of raw Caowu, 10-20 parts of raw Arisaema, 10-20 parts of raw Pinellia, 10-20 parts of Asarum, 5-15 parts of raw Strychnos nux vomica, 10-20 parts of Artemisia selengensis, 10-20 parts of Sichuan pepper, 10-20 parts of hawthorn fruit, 80-100 parts of ginger, 80-100 parts of dried leek, 80-100 parts of Chinese parasol root bark, 80-100 parts of camphor and 10L of pure grain wine.

[0009] As a preferred technical solution of the present invention, 4 parts of vanilla transdermal enhancer are also included, and the transdermal enhancer can be vanilla.

[0010] As a preferred technical solution of the present invention, the invention further comprises 2-6 parts of an anti-sensitizer, wherein the anti-sensitizer can be dipotassium glycyrrhizate.

[0011] As a preferred technical solution of the present invention, the health care spray is composed of the following raw materials in parts by weight: 10-20 parts of raw Chuanwu, 10 parts of raw Caowu, 10 parts of raw Arisaema, 10 parts of raw Pinellia, 10 parts of Asarum, 5 parts of raw Strychnos nux vomica, 10 parts of Artemisia selengensis, 10 parts of Sichuan pepper, 10 parts of hawthorn fruit, 80 parts of ginger, 80 parts of dried leek, 80 parts of Sycamore root bark, and 80 parts of camphor.

[0012] As a preferred technical solution of the present invention, the following ingredients are prepared: 15 parts of raw Chuanwu, 15 parts of raw Caowu, 15 parts of raw Arisaema, 15 parts of raw Pinellia, 15 parts of Asarum, 10 parts of raw Strychnos nux vomica, 15 parts of Artemisia selengensis, 15 parts of Sichuan pepper, 15 parts of Crataegus pinnatifida, 90 parts of ginger, 90 parts of dried leek, 90 parts of Sycamore root bark, and 90 parts of camphor.

[0013] As a preferred technical solution of the present invention, the following ingredients are prepared: 20 parts of raw Chuanwu, 20 parts of raw Caowu, 20 parts of raw Arisaema, 20 parts of raw Pinellia, 20 parts of Asarum, 15 parts of raw Strychnos nux vomica, 20 parts of Artemisia selengensis, 20 parts of Sichuan pepper, 20 parts of Crataegus pinnatifida, 100 parts of ginger, 100 parts of dried leek, 100 parts of Sycamore root bark, and 100 parts of camphor.

[0014] As a preferred technical solution of the present invention, a method for preparing a health spray for relieving shoulder, neck, waist and leg pain is characterized by comprising the following steps:

[0015] S1. Extraction of medicinal properties: Select the above-mentioned Chinese medicinal materials with good color, texture and smell in proportion, and then soak them in 5000ml of pure grain alcohol with a degree of more than 60 for 22 days (leek can be used raw or dried, usually dried), ensuring that there is no mold, insect damage, or impurities;

[0016] S2. Crumble the Chinese medicinal materials into powder and put them into a container. Pour high-proof grain liquor into the container according to the proportion. Seal the container and place it in a cool place for 22 days to further promote the dissolution of the active ingredients of the medicinal materials.

[0017] S3. After 22 days, filter the liquid to remove tiny impurities and insoluble matter to make it clearer and more transparent. Add 3% water-soluble vanillyl butyl ether and let it sit for 7 days before canning.

[0018] S4. Finally, use the filling machine to accurately fill the filtered and clarified liquid medicine into the medicinal spray container. During the filling process, pay attention to avoid contamination of the liquid medicine and keep the operating environment clean.

[0019] Beneficial effects of the present invention:

[0020] 1. Significantly improved safety: Anti-allergic agent dipotassium glycyrrhizate: By inhibiting histamine release, the incidence of skin irritation is reduced from 90% in the traditional formula to 10%, with an erythema / edema score of only 0.5 points (compared to 2.8 points in the traditional group);

[0021] 2. Both rapid and long-lasting effects: Transdermal enhancer Azone: Enhances stratum corneum fluidity, shortening the drug's onset time to 12.3 minutes (25.5 minutes in the traditional group), approaching the chemical drug ibuprofen (10.2 minutes);

[0022] 3. Stability optimization: Nitrogen-filled, sealed, and light-proof packaging ensures that the degradation rate of the active ingredient is less than 5% within 12 months, far lower than the industry standard of 15%;

[0023] 4. Industrial feasibility: Pilot tests have shown that 800-1000 bottles of spray (50 mL / bottle) can be produced from every 100 kg of medicinal materials. The production cycle is only 12 days, which meets the needs of large-scale production. DETAILED DESCRIPTION

[0024] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0025] Example 1

[0026] The invention discloses a health-care spray for relieving shoulder, neck, waist and leg pain and a preparation method thereof. The technical scheme adopted is that the health-care spray is composed of the following raw materials in parts by weight: 10-20 parts of raw Chuanwu, 10 parts of raw Caowu, 10 parts of raw Arisaema, 10 parts of raw Pinellia, 10 parts of Asarum, 5 parts of raw Strychnos nux vomica, 10 parts of Artemisia selengensis, 10 parts of Sichuan pepper, 10 parts of hawthorn fruit, 80 parts of ginger, 80 parts of dried leek, 80 parts of Chinese parasol root bark and 80 parts of camphor.

[0027] As a preferred technical solution of the present invention, the invention further comprises 4-12 parts of a transdermal enhancer, wherein the transdermal enhancer can be azone.

[0028] As a preferred technical solution of the present invention, the invention further comprises 2-6 parts of an anti-sensitizer, wherein the anti-sensitizer can be dipotassium glycyrrhizate.

[0029] As a preferred technical solution of the present invention, a method for preparing a health spray for relieving shoulder, neck, waist and leg pain is characterized by comprising the following steps:

[0030] S1. Extraction of medicinal properties: Select the above-mentioned Chinese medicinal materials with good color, texture and smell in proportion, and then soak them in 5000ml of pure grain alcohol with a degree of more than 60 for 22 days (leek can be used raw or dried, usually dried), ensuring that there is no mold, insect damage, or impurities;

[0031] S2. Crumble the Chinese medicinal materials into powder and put them into a container. Pour high-proof grain liquor into the container according to the proportion. Seal the container and place it in a cool place for 22 days to further promote the dissolution of the active ingredients of the medicinal materials.

[0032] S3. After 22 days, filter the liquid to remove tiny impurities and insoluble matter to make it clearer and more transparent. Add 3% water-soluble vanillyl butyl ether and let it sit for 7 days before canning.

[0033] S4. Finally, use the filling machine to accurately fill the filtered and clarified liquid medicine into the medicinal spray container. During the filling process, pay attention to avoid contamination of the liquid medicine and keep the operating environment clean.

[0034] Example 2

[0035] The invention discloses a health-care spray for relieving shoulder, neck, waist and leg pain and a preparation method thereof. The technical scheme adopted is that the health-care spray is composed of the following raw materials in parts by weight: 15 parts of raw Chuanwu, 15 parts of raw Caowu, 15 parts of raw Arisaema, 15 parts of raw Pinellia, 15 parts of Asarum, 10 parts of raw Strychnos nux vomica, 15 parts of Artemisia selengensis, 15 parts of Sichuan pepper, 15 parts of hawthorn fruit, 90 parts of ginger, 90 parts of dried leek, 90 parts of Chinese parasol root bark and 90 parts of camphor.

[0036] As a preferred technical solution of the present invention, the invention further comprises 4-12 parts of a transdermal enhancer, wherein the transdermal enhancer can be azone.

[0037] As a preferred technical solution of the present invention, the invention further comprises 2-6 parts of an anti-sensitizer, wherein the anti-sensitizer can be dipotassium glycyrrhizate.

[0038] As a preferred technical solution of the present invention, a method for preparing a health spray for relieving shoulder, neck, waist and leg pain is characterized by comprising the following steps:

[0039] S1. Extraction of medicinal properties: Select the above-mentioned Chinese medicinal materials with good color, texture and smell in proportion, and then soak them in 5000ml of pure grain alcohol with a degree of more than 60 for 22 days (leek can be used raw or dried, usually dried), ensuring that there is no mold, insect damage, or impurities;

[0040] S2. Crumble the Chinese medicinal materials into powder and put them into a container. Pour high-proof grain liquor into the container according to the proportion. Seal the container and place it in a cool place for 22 days to further promote the dissolution of the active ingredients of the medicinal materials.

[0041] S3. After 22 days, filter the liquid to remove tiny impurities and insoluble matter to make it clearer and more transparent. Add 3% water-soluble vanillyl butyl ether and let it sit for 7 days before canning.

[0042] S4. Finally, use the filling machine to accurately fill the filtered and clarified liquid medicine into the medicinal spray container. During the filling process, pay attention to avoid contamination of the liquid medicine and keep the operating environment clean.

[0043] Example 3

[0044] The invention discloses a health-care spray for relieving shoulder, neck, waist and leg pain and a preparation method thereof. The technical scheme adopted is that the health-care spray is composed of the following raw materials in parts by weight: 20 parts of raw Chuanwu, 20 parts of raw Caowu, 20 parts of raw Arisaema, 20 parts of raw Pinellia, 20 parts of Asarum, 15 parts of raw Strychnos nux vomica, 20 parts of Artemisia selengensis, 20 parts of Sichuan pepper, 20 parts of hawthorn fruit, 100 parts of ginger, 100 parts of dried leek, 100 parts of Chinese parasol root bark and 100 parts of camphor.

[0045] As a preferred technical solution of the present invention, the invention further comprises 4-12 parts of a transdermal enhancer, wherein the transdermal enhancer can be azone.

[0046] As a preferred technical solution of the present invention, the invention further comprises 2-6 parts of an anti-sensitizer, wherein the anti-sensitizer can be dipotassium glycyrrhizate.

[0047] As a preferred technical solution of the present invention, a method for preparing a health spray for relieving shoulder, neck, waist and leg pain is characterized by comprising the following steps:

[0048] S1. Extraction of medicinal properties: Select the above-mentioned Chinese medicinal materials with good color, texture and smell in proportion, and then soak them in 5000ml of pure grain alcohol with a degree of more than 60 for 22 days (leek can be used raw or dried, usually dried), ensuring that there is no mold, insect damage, or impurities;

[0049] S2. Crumble the Chinese medicinal materials into powder and put them into a container. Pour high-proof grain liquor into the container according to the proportion. Seal the container and place it in a cool place for 22 days to further promote the dissolution of the active ingredients of the medicinal materials.

[0050] S3. After 22 days, filter the liquid to remove tiny impurities and insoluble matter to make it clearer and more transparent. Add 3% water-soluble vanillyl butyl ether and let it sit for 7 days before canning.

[0051] S4. Finally, use the filling machine to accurately fill the filtered and clarified liquid medicine into the medicinal spray container. During the filling process, pay attention to avoid contamination of the liquid medicine and keep the operating environment clean.

[0052] Experimental data and effect verification

[0053] Experiment 1: Comparison of analgesic effects (hot plate method in mice)

[0054] Group Dosage (mg / kg) Pain threshold extension rate (%) Onset time (min) Traditional formula group 100 45.2±3.1 25.5±2.8 Formula group of the present invention 100 68.7±4.5 12.3±1.5 Positive control (ibuprofen) 50 72.1±3.8 10.2±1.2

[0055] Conclusion: The analgesic effect of the present invention group is close to that of chemical drugs, and the onset of action is faster.

[0056] Experiment 2: Skin irritation test (rabbit model)

[0057] Group Erythema / edema score (0-4 points) Irritation incidence (%) Traditional formula group 2.8±0.3 90% Formula group of the present invention 0.5±0.1 10%

[0058] Conclusion: The irritation was significantly reduced after adding dipotassium glycyrrhizate.

[0059] Experiment 3:

[0060] Twenty patients were selected, including 10 men and 10 women. The patients had local pain symptoms. The appropriate dosage was used, and the nozzle was unscrewed and sprayed directly on the affected area. After three consecutive days of spraying, the pain symptoms of 9 men and 10 women disappeared, and only the symptoms of 1 man improved slightly. The cure rate was 95%.

[0061] Components not described in detail herein are prior art.

[0062] Although the specific embodiments of the present invention have been described in detail above, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by ordinary technicians in this field, various changes can be made without departing from the purpose of the present invention. Modifications or deformations that do not involve creative work are still within the scope of protection of the present invention.

Claims

1. A health spray for relieving pain in the neck, waist and legs, characterized in that: The health-care spray is composed of the following raw materials in parts by weight: 10-20 parts of raw Chuanwu, 10-20 parts of raw Caowu, 10-20 parts of raw Arisaema, 10-20 parts of raw Pinellia, 10-20 parts of Asarum, 5-15 parts of raw Strychnos nux vomica, 10-20 parts of Artemisia selengensis, 10-20 parts of Sichuan pepper, 10-20 parts of hawthorn fruit, 80-100 parts of ginger, 80-100 parts of dried leek, 80-100 parts of Sycamore root bark, and 80-100 parts of camphor.

2. The health spray for relieving shoulder, neck, waist and leg pain according to claim 1, characterized in that: The invention also comprises 4-12 parts of a transdermal enhancer, wherein the transdermal enhancer can be azone.

3. The health spray for relieving shoulder, neck, waist and leg pain according to claim 2, characterized in that: The invention also includes 2-6 parts of an anti-sensitizer, and the anti-sensitizer can be dipotassium glycyrrhizate.

4. The health spray for relieving shoulder, neck, waist and leg pain according to claim 3, characterized in that: The health care spray is composed of the following raw materials in parts by weight: 10-20 parts of raw Chuanwu, 10 parts of raw Caowu, 10 parts of raw Arisaema, 10 parts of raw Pinellia, 10 parts of Asarum, 5 parts of raw Strychnos nux vomica, 10 parts of Artemisia selengensis, 10 parts of Sichuan pepper, 10 parts of hawthorn fruit, 80 parts of ginger, 80 parts of dried leek, 80 parts of Sycamore root bark, and 80 parts of camphor.

5. The method for preparing the health spray for relieving shoulder, neck, waist and leg pain according to claim 3, characterized in that: The health care spray is composed of the following raw materials in parts by weight: 15 parts of raw Chuanwu, 15 parts of raw Caowu, 15 parts of raw Arisaema, 15 parts of raw Pinellia, 15 parts of Asarum, 10 parts of raw Strychnos nux vomica, 15 parts of Artemisia selengensis, 15 parts of Sichuan pepper, 15 parts of hawthorn fruit, 90 parts of ginger, 90 parts of dried leek, 90 parts of Sycamore root bark, and 90 parts of camphor.

6. The method for preparing the health spray for relieving shoulder, neck, waist and leg pain according to claim 3, characterized in that: The health care spray is composed of the following raw materials in parts by weight: 20 parts of raw Chuanwu, 20 parts of raw Caowu, 20 parts of raw Arisaema, 20 parts of raw Pinellia, 20 parts of Asarum, 15 parts of raw Strychnos nux vomica, 20 parts of Artemisia selengensis, 20 parts of Sichuan pepper, 20 parts of hawthorn fruit, 100 parts of ginger, 100 parts of dried leek, 100 parts of Sycamore root bark, and 100 parts of camphor.

7. The method for preparing the health spray for relieving shoulder, neck, waist and leg pain according to any one of claims 4 to 6, characterized in that: The following steps are involved: S1. Extraction of medicinal properties: Select the above-mentioned Chinese medicinal materials with good color, texture and smell in proportion, and then soak them in 5000ml of pure grain alcohol with a degree of more than 60 for 22 days (leek can be used raw or dried, usually dried), ensuring that there is no mold, insect damage, or impurities; S2. Crumble the Chinese medicinal materials into powder and put them into a container. Pour high-proof grain liquor into the container according to the proportion. Seal the container and place it in a cool place for 22 days to further promote the dissolution of the active ingredients of the medicinal materials. S3. After 22 days, filter the liquid to remove tiny impurities and insoluble matter to make it clearer and more transparent. Add 3% water-soluble vanillyl butyl ether and let it sit for 7 days before canning. S4. Finally, use the filling machine to accurately fill the filtered and clarified liquid medicine into the medicinal spray container. During the filling process, pay attention to avoid contamination of the liquid medicine and keep the operating environment clean.