A targeted transdermal drug delivery device for traditional Chinese medicine

Abstract

This application discloses a targeted transdermal drug delivery device for traditional Chinese medicine, relating to the field of biomedical engineering technology. The device includes a transdermal drug delivery component comprising a drug delivery component and an application assembly. The drug delivery component presses and delivers the drug to the application assembly. The application assembly includes a middle plate and multiple pyramid-shaped silicone microprotrusions arranged in an array on the surface of the middle plate. An upper and lower telescopic component extends and retracts to transmit force to the drug delivery component, causing the silicone microprotrusions to be compressed and tightly adhered to the skin surface. Through the pressure gradient design of the silicone microprotrusion tips, reversible shear slippage is induced in the stratum corneum lipid bilayer without damaging the skin integrity, forming loosened pores with a gradient pore size distribution. This creates pores that can be directionally delivered to the skin. Compared to traditional plasters, the transdermal drug delivery efficiency is increased several times. Compared to microneedle technology, it avoids the risk of dermal layer damage, achieving zero-invasive drug delivery.

Description

Technical Field

[0001] This application relates to the biomedical engineering industry, and in particular to a targeted transdermal drug delivery device for traditional Chinese medicine. Background Technology

[0002] Transdermal drug delivery equipment for traditional Chinese medicine is a medical device that uses modern technology to deliver the effective components of traditional Chinese medicine through the skin barrier into the human body in order to achieve the purpose of treating diseases.

[0003] Chinese patent CN104491980B discloses a transdermal TCM therapy device, including a chip module capable of human-computer interaction, data storage, command issuance, detection, and control. The first output of the module is connected to a time display for showing the duration of the heat application, and the second output is connected to a temperature display for showing the temperature of the heat application. The control drive of the module is connected to one end of a vacuum pump, and the other end of the vacuum pump is connected to a heating chamber via an air duct. The heating chamber is electrically connected to the module. Since the heating chamber can both generate heat and negative pressure, it can perform cupping therapy or suction-release therapy, realizing a novel therapy combining cupping and herbal heat application.

[0004] Transdermal drug delivery technology, as a novel drug delivery method, has shown significant advantages in the treatment of chronic diseases and local drug administration. However, existing technologies still face multiple bottlenecks in practical applications: traditional plasters rely on passive diffusion, resulting in low drug penetration efficiency, especially for ingredients with larger molecular weights that are almost impossible to penetrate the skin; while microneedle puncture technology can improve penetration, it damages the skin barrier structure, posing a risk of infection and accompanied by significant pain, leading to poor patient compliance.

[0005] Therefore, this application proposes a targeted transdermal drug delivery device for traditional Chinese medicine to solve the above problems. Summary of the Invention

[0006] In view of the problems existing in the prior art, this application is hereby filed.

[0007] To solve the above-mentioned technical problems, this application provides the following technical solution: a directional transdermal drug delivery device for traditional Chinese medicine, comprising a base, a rotating arm assembly, an upper and lower telescopic component, a clamping component, and a transdermal drug delivery component; wherein, the rotating arm assembly is fixed to a horizontal plane by the base; the upper and lower telescopic component fixes the end of the rotating arm assembly and achieves rotation of the horizontal plane through the rotating arm assembly; the clamping component is suspended on the upper and lower telescopic component and adjusts the clamping range of the clamping component by extending and retracting the upper and lower telescopic component; the transdermal drug delivery component is clamped by the clamping component and pressed against the patient's back, the transdermal drug delivery component includes a drug delivery component and an application component, the drug delivery component presses and delivers drug to the application component, the application component includes a middle plate and a plurality of pyramid-shaped silicone micro-protrusions arranged in an array on the surface of the middle plate, the upper and lower telescopic component extends and retracts to transmit force to the drug delivery component so that the silicone micro-protrusions are pressed and thus tightly adhere to the skin surface, so that the lipid arrangement of the stratum corneum of the skin surface is loosened to form a "honeycomb" pore.

[0008] As a preferred embodiment of the targeted transdermal drug delivery device for traditional Chinese medicine described in this application, the silicone micro-protrusions include an outer shell layer, and micro-protrusions are provided on multiple sides of the outer shell layer. The tip of the outer shell layer and the micro-protrusions are coated with keratin softening enzyme.

[0009] As a preferred embodiment of the directional transdermal drug delivery device for traditional Chinese medicine described in this application, the drug delivery component includes a drug delivery cylinder and an outer armature plate, the outer armature plate being connected to the outer side of the bottom end of the drug delivery cylinder. The drug delivery component also includes an air pump and an air pipe, the air pipe being connected to the air outlet of the air pump, and the drug liquid in the drug delivery cylinder being squeezed out by the air pump entering and exiting.

[0010] As a preferred embodiment of the directional transdermal drug delivery device for traditional Chinese medicine described in this application, the transdermal drug delivery component further includes a pressure-seal assembly and a heat-releasing assembly. The pressure-seal assembly includes a first pressure-seal component and a second pressure-seal component, which are respectively disposed on both sides of the intermediate plate. The first pressure-seal component is used to seal the gap between the intermediate plate and the skin surface, and the second pressure-seal component is used to seal the gap between the intermediate plate and the outer connecting plate. The surface of the intermediate plate is provided with a plurality of rectangular through grooves arranged in an array, and the plurality of rectangular through grooves correspond to the plurality of silicone micro-protrusions.

[0011] As a preferred embodiment of the targeted transdermal drug delivery device for traditional Chinese medicine described in this application, wherein: a filter membrane and a drug-carrying membrane are provided at each rectangular slot of the intermediate plate, wherein the drug-carrying membrane is located on the side of the rectangular slot near the silicone micro-protrusion; both the filter membrane and the drug-carrying membrane have a multi-layer structure design, the surface of the filter membrane has nanopores of different pore sizes to intercept ineffective macromolecules in the drug; the drug-carrying membrane is made of different materials to improve the permeability of different drug components.

[0012] As a preferred embodiment of the directional transdermal drug delivery device for traditional Chinese medicine described in this application, the first pressure-distributing component includes a lower silicone strip and a vacuum adsorption strip connected to the surface of the lower silicone strip, wherein the lower silicone strip forms a frame structure to enclose the lower surface of the intermediate plate; the second pressure-distributing component includes an upper silicone strip and a frame plate connected to the surface of the upper silicone strip, wherein the frame plate is connected to the outer mounting plate through the upper silicone strip.

[0013] As a preferred embodiment of the directional transdermal drug delivery device for traditional Chinese medicine described in this application, wherein: a telescopic frame pressure plate is connected to the surface of the outer armature plate, the telescopic frame pressure plate includes an upper frame pressure strip and a lower frame pressure strip, wherein the upper frame pressure strip is locked and moved within the inner cavity of the lower frame pressure strip to adjust the length of the telescopic frame pressure plate, and multiple telescopic pressure rods are provided at the bottom of the outer armature plate and the lower cylinder of the disc, the telescopic pressure rods and the telescopic frame pressure plate extend and retract synchronously.

[0014] As a preferred embodiment of the directional transdermal drug delivery device for traditional Chinese medicine described in this application, the minimum height at which the telescopic pressure bar and telescopic frame plate retract is the superimposed height of the upper silicone strip and the frame plate.

[0015] As a preferred embodiment of the directional transdermal drug delivery device for traditional Chinese medicine described in this application, the heat release component includes two rectangular plates and a connecting rod, wherein the two rectangular plates are connected by the connecting rod.

[0016] As a preferred embodiment of the directional transdermal drug delivery device for traditional Chinese medicine described in this application, the upper and lower telescopic components include a cylinder and an execution plate, the cylinder is mounted on the rotating arm assembly, and the execution plate is fixed to the bottom of the cylinder.

[0017] L-shaped grooves are provided at the relative positions of the outer armature plate and the middle plate. The two rectangular plates are rotatably connected in the L-shaped grooves. A temperature sensor is provided on the outer armature plate. A controller is provided on the cylinder. When the temperature sensor detects that the temperature of the transdermal drug leakage site has increased, the controller controls the output end of the cylinder to move upward.

[0018] The beneficial effects of this application are as follows: This application uses multiple silicone micro-protrusions arranged in an array on the surface of the intermediate plate. The silicone micro-protrusions adopt a pyramid-shaped structure. Through the pressure gradient design of the silicone micro-protrusion tips, the lipid bilayer of the stratum corneum is reversibly sheared and slipped without damaging the integrity of the skin. This creates loosened pores with a gradient distribution of pore size, forming pores that can be directionally delivered to the skin. Compared with traditional plasters, the transdermal drug delivery efficiency is increased many times. Compared with microneedle technology, it avoids the risk of dermal layer damage and achieves drug delivery with zero wounds. Attached Figure Description

[0019] To more clearly illustrate the technical solutions of the embodiments of this application, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the overall structure of a targeted transdermal drug delivery system for traditional Chinese medicine.

[0021] Figure 2 Axonometric drawing of the overall structure of a directional transdermal drug delivery system for traditional Chinese medicine;

[0022] Figure 3 This is a schematic diagram of the overall structure of the clamping component in this application;

[0023] Figure 4 This is a schematic diagram of the overall structure of the drug delivery component in this application;

[0024] Figure 5 This is a schematic diagram of the overall structure of the drug delivery cartridge in this application;

[0025] Figure 6 for Figure 5 A magnified view of the structure of part A;

[0026] Figure 7 This is a schematic diagram of the overall structure of the silicone micro-protrusions in this application;

[0027] Figure 8 This is a schematic diagram of the overall structure of the pressure-sharing assembly in this application;

[0028] Figure 9 for Figure 8 Enlarged view of the B structure.

[0029] Explanation of reference numerals in the attached drawings: 100, base; 200, rotating arm assembly; 210, first support arm; 220, second horizontal arm; 230, third rotating arm; 300, vertical telescopic component; 310, cylinder one; 320, execution plate; 400, clamping component; 410, suspension plate; 420, clamping assembly; 421, positioning plate two; 422, inner connecting cylinder; 423, outer clamping cylinder; 424, linkage rod; 425, gripper; 430, drive assembly; 431, cylinder two; 432, drive ring; 433, positioning plate one; 500, transdermal drug delivery component; 510, drug delivery component; 511, drug delivery cylinder; 5111, conical upper cylinder; 5112, circular lower cylinder; 5113, guide hole; 512, partition plate; 513, outer armature plate; 51 4. Air pump; 515. Air tube; 516. Clamp; 520. Application assembly; 521. Silicone micro-protrusion; 5211. Outer shell layer; 5212. Inner shell layer; 5213. Connecting block; 5214. Micro-protrusion; 522. Intermediate plate; 5221. Rectangular through groove; 5222. Filter membrane; 5223. Drug-loaded membrane; 530. Pressure-dividing sealing assembly; 531. First pressure-dividing component; 5311. Lower silicone strip; 5312. Vacuum adsorption strip; 532. Second pressure-dividing component; 5321. Upper silicone strip; 5322. Frame plate; 533. Telescopic frame pressure plate; 5331. Upper frame pressure strip; 5332. Lower frame pressure strip; 534. Telescopic pressure rod; 540. Heat release assembly; 541. Rectangular plate; 542. Connecting rod; 543. Temperature sensor. Detailed Implementation

[0030] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, the specific embodiments of this application will be described in detail below with reference to the accompanying drawings.

[0031] Many specific details are set forth in the following description in order to provide a full understanding of this application. However, this application may also be implemented in other ways different from those described herein. Those skilled in the art can make similar extensions without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0032] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of this application. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that excludes other embodiments.

[0033] Example 1

[0034] Reference Figures 1-9 As shown, this is the first embodiment of the present application, which provides a targeted transdermal drug delivery device for traditional Chinese medicine, comprising:

[0035] The base 100 is set on a flat surface.

[0036] The rotating arm assembly 200 is fixed to the plane by the base 100. The rotating arm assembly 200 includes a first support arm 210, a second horizontal arm 220 and a third rotating arm 230. The first support arm 210 and the second horizontal arm 220 are rotatably connected to each other, and the second horizontal arm 220 and the third rotating arm 230 are rotatably connected to each other.

[0037] The vertical telescopic component 300 is fixed at the end of the rotating arm assembly 200. It achieves horizontal rotation through the rotating arm assembly 200. The vertical telescopic component 300 includes a cylinder 310 and an actuator plate 320. The cylinder 310 is mounted on the end of the third rotating arm 230 away from the second horizontal arm 220, and the actuator plate 320 is fixed to the bottom of the cylinder 310.

[0038] like Figure 2-Figure 3 As shown, the clamping component 400 is suspended on the upper and lower telescopic component 300, and the clamping range of the clamping component 400 is adjusted by extending and retracting the upper and lower telescopic component 300.

[0039] The clamping component 400 includes a suspension plate 410, a clamping assembly 420, and a drive assembly 430; the drive assembly 430 includes a second cylinder 431, a drive ring 432, and a first positioning plate 433. The second cylinder 431 is fixed to the surface of the suspension plate 410 through the first positioning plate 433, and the drive ring 432 is fixed to the output end surface of the second cylinder 431. The output end of the second cylinder 431 drives the drive ring 432 to move up and down reciprocally.

[0040] The clamping assembly 420 includes a positioning plate 421, an inner connecting cylinder 422, and an outer clamping cylinder 423. A drive ring 432 is located at the top of the outer clamping cylinder 423. A linkage rod 424 is provided between the outer clamping cylinder 423 and the drive ring 432. The drive ring 432, which moves up and down, drives the outer clamping cylinder 423 to move up and down synchronously through the linkage rod 424. The inner connecting cylinder 422 is fixed to the suspension plate 410 by the positioning plate 421. The surface of the inner connecting cylinder 422 has multiple equally spaced annularly distributed mounting slots. Grippers 425 are installed in the mounting slots. The multiple grippers 425 expand or contract synchronously at equal intervals and angles along the radial direction with the central axis of the inner connecting cylinder 422 as the reference, so as to achieve gripping.

[0041] A transdermal drug delivery component 500, held by a clamping component 400 and pressed against the patient's back, includes a drug delivery component 510 and an application assembly 520. The drug delivery component 510 presses against and delivers drug to the application assembly 520. The application assembly 520 includes an intermediate plate 522 and multiple pyramid-shaped silicone micro-protrusions 521 arranged in an array on the surface of the intermediate plate 522. An up-and-down telescopic component 300 extends and retracts to transmit force to the drug delivery component 510, causing the silicone micro-protrusions 521 to be pressed and thus tightly adhered to the skin surface, loosening the lipid arrangement of the stratum corneum of the skin surface to form "honeycomb" pores. Because the pyramid-shaped tips of the silicone micro-protrusions 521 preferentially contact the skin surface, the silicone micro-protrusions 521... The pressure along the slope of the silicone micro-protrusion 521 decreases, forming a pore size gradient to create a nanoscale lipid interstitial network of indentations on the skin surface, forming micron-sized pores of varying sizes to allow nanoscale drug molecules of different molecular weights to penetrate. Compared to medicated plasters, the silicone micro-protrusion 521 significantly improves drug delivery efficiency. Compared to microneedle puncture, which creates micron-sized penetrating micropores that directly damage the skin barrier structure, this application uses silicone micro-protrusion 521 to temporarily loosen the lipid bilayer of the stratum corneum by applying pressure, forming a natural lipid interstitial network of mechanically loosened lipid layers. This is non-invasive and painless, greatly improving the transdermal drug delivery efficiency while completely avoiding the pain and infection risks of traditional puncture techniques.

[0042] This application utilizes the mechanical stress of silicone micro-protrusions 521 to reversibly loosen the lipid bilayer of the stratum corneum without damaging the integrity of the skin, forming nanoscale penetration channels adapted to different molecular weights. Compared with microneedle puncture technology, this achieves non-invasive, painless, and high-precision compound delivery.

[0043] like Figure 7 As shown, the silicone micro-protrusion 521 includes an outer shell layer 5211 and an inner shell layer 5212. A drug delivery channel is formed between the outer shell layer 5211 and the inner shell layer 5212. Connecting blocks 5213 are provided at the four corners of the outer shell layer 5211 and the inner shell layer 5212. The outer shell layer 5211 and the inner shell layer 5212 are connected through the connecting blocks 5213. The inner shell layer 5212 and the connecting blocks 5213 reduce the inner cavity volume of the outer shell layer 5211, thereby reducing the amount of drug stored in the inner cavity of the outer shell layer 5211.

[0044] Micro-protrusions 5214 are provided on all four sides of the outer shell layer 5211. The tip of the outer shell layer 5211 and the micro-protrusions 5214 on the sides of the outer shell layer 5211 are coated with keratin softening enzymes to release and degrade keratin under pressure, thereby further expanding the pores. The multiple micro-protrusions 5214 on the sides of the outer shell layer 5211 realize multiple stress points, effectively forming multiple effective stress points on the skin surface, compressing the skin surface to form pores for targeted drug delivery.

[0045] like Figure 4 and Figure 5 As shown, the drug delivery component 510 includes a drug delivery cylinder 511, a partition plate 512, and an outer armature plate 513. The drug delivery cylinder 511 includes a conical upper cylinder 5111 and a circular lower cylinder 5112 connected as one piece. The outer armature plate 513 is installed at the bottom end of the circular lower cylinder 5112. The surface of the circular lower cylinder 5112 is provided with a plurality of guide holes 5113. The partition plate 512 is disposed in the inner cavity of the drug delivery cylinder 511 and guided by the conical upper cylinder 5111. Moving along the axis of the conical upper cylinder 5111, the partition plate 512 tends to move toward the circular lower cylinder 5112 to squeeze the drug liquid into the guide holes 5113.

[0046] The conical upper cylinder 5111 divides the inner cavity into an air chamber and a liquid medicine chamber through a partition plate 512. The partition plate 512 pushes the liquid medicine in the liquid medicine chamber into the guide hole 5113.

[0047] The drug delivery component 510 also includes an air pump 514 and an air tube 515. The air tube 515 is connected to the air outlet of the air pump 514, and its other end is connected to the end of the conical upper cylinder 5111 that is away from the lower cylinder 5112. The air pump 514 increases the air in the air chamber to push the partition plate 512 toward the lower cylinder 5112 to deliver the drug solution.

[0048] Multiple clamps 516 are fixed to the outer surface of the drug delivery cartridge 511, and the air pump 514 is assembled to the outer surface of the drug delivery cartridge 511 through the clamps 516.

[0049] like Figure 2 , Figures 4-6 , Figures 8-9 As shown, the transdermal drug delivery component 500 also includes a pressure-seal assembly 530 and a heat release assembly 540. The pressure-seal assembly 530 includes a first pressure-seal component 531 and a second pressure-seal component 532. The first pressure-seal component 531 and the second pressure-seal component 532 are respectively disposed on both sides of the intermediate plate 522. The first pressure-seal component 531 is used to seal the gap between the intermediate plate 522 and the skin surface. The second pressure-seal component 532 is used to seal the gap between the intermediate plate 522 and the outer connecting plate 513. The surface of the intermediate plate 522 has a plurality of rectangular through grooves 5221 arranged in an array. The plurality of rectangular through grooves 5221 correspond to a plurality of silicone micro-protrusions 521.

[0050] like Figure 5 and Figure 6 Each rectangular slot 5221 of the intermediate plate 522 is provided with a filter membrane 5222 and a drug-carrying membrane 5223, wherein the drug-carrying membrane 5223 is located on the side of the rectangular slot 5221 near the silicone micro-protrusion 521; both the filter membrane 5222 and the drug-carrying membrane 5223 are designed with a multi-layer structure. The surface of the filter membrane 5222 is provided with nanopores of different sizes to intercept ineffective macromolecules in the drug; the drug-carrying membrane 5223 is made of different materials to improve the permeability of different drug components.

[0051] Specifically, the filter membrane 5222 consists of a surface membrane, a middle membrane, and a bottom membrane from top to bottom. The surface membrane has nanopores with a diameter of 50 nm, the middle membrane has nanopores with a diameter of 20 nm, and the bottom membrane has nanopores with a diameter of 2 nm. Through the synergistic filtration of the surface membrane, middle membrane, and bottom membrane, component precipitation and stratification are eliminated, preserving the original efficacy of the medicine. The drug-loaded membrane 5223 consists of a hydrophilic layer, an amphiphilic layer, and a hydrophobic layer from top to bottom. The hydrophilic layer loads polar components such as alkaloids, Polysaccharides, containing sodium alginate hydrogel, are preferentially released via capillary action. The amphiphilic layer is loaded with moderately polar components such as flavonoid glycosides. A chitosan-lipid composite membrane is used to control the release using osmotic pressure difference. The hydrophobic layer is loaded with non-polar components such as volatile oils. The release is carried out through a concentration gradient-dependent diffusion via a microporous silica carrier. The three-level synergy of "physical sieving-chemical controlled release-bioadaptation" is solved through the filter membrane 5222 and the drug-loaded membrane 5223, which overcomes the problems of component interference and low efficiency in transdermal drug delivery of compound traditional Chinese medicine.

[0052] like Figures 8-9 As shown, the first pressure-distributing component 531 includes a lower silicone strip 5311 and a vacuum adsorption strip 5312 connected to the surface of the lower silicone strip 5311. The lower silicone strip 5311 forms a frame structure to enclose the lower surface of the intermediate plate 522. The second pressure-distributing component 532 includes an upper silicone strip 5321 and a frame plate 5322 connected to the surface of the upper silicone strip 5321. The frame plate 5322 is connected to the outer mounting plate 513 through the upper silicone strip 5321.

[0053] like Figures 8-9 As shown, a telescopic frame strip pressure plate 533 is connected to the surface of the outer armature plate 513. The telescopic frame strip pressure plate 533 includes an upper frame pressure strip 5331 and a lower frame pressure strip 5332. The upper frame pressure strip 5331 is engaged and moved within the cavity of the lower frame pressure strip 5332 to adjust the length of the telescopic frame strip pressure plate 533. Multiple telescopic pressure rods 534 are provided at the bottom of the outer armature plate 513 and the lower cylinder 5112. The telescopic pressure rods 534 and the telescopic frame strip pressure plate 533 extend and retract synchronously. The lowest height at which the telescopic pressure rods 534 and the telescopic frame strip pressure plate 533 retract is the superimposed height of the upper silicone strip 5321 and the frame strip plate 5322.

[0054] The upper frame pressure strip 5331 is fixed to the surface of the outer armature plate 513, the lower frame pressure strip 5332 is fixed to the surface of the middle plate 522, one end of the telescopic pressure rod 534 is fixed to the middle plate 522, and the other end is fixed to the outer armature plate 513 or the lower cylinder of the disc 5112. There are multiple telescopic pressure rods 534, which are arranged on the middle plate 522 and avoid the position of the rectangular through groove 5221.

[0055] Example 2

[0056] Reference Figures 8-9 This is the second embodiment of the present application. This embodiment is based on the previous embodiment, except that the heat release component 540 includes two rectangular plates 541 and a connecting rod 542, and the two rectangular plates 541 are connected by the connecting rod 542.

[0057] The outer connecting plate 513 and the middle plate 522 are each provided with an L-shaped groove at their relative positions. Two rectangular plates 541 are rotatably connected in the L-shaped groove. The outer connecting plate 513 is equipped with a temperature sensor 543, and the cylinder 310 is equipped with a controller. When the temperature sensor 543 detects that the temperature of the transdermal drug leakage site has increased, the controller controls the output end of the cylinder 310 to move upward.

[0058] A vibrator is also fixed to the surface of the outer pressure cylinder 423.

[0059] Working principle: Manually push the second horizontal arm 220 and the third rotating arm 230 to rotate the third rotating arm 230 to the target skin area, start the cylinder 310 to press down the clamping component 400 and the transdermal drug delivery component 500, turn on the vibrator, and transmit the vibration to the transdermal drug delivery component 500 through the external pressure cylinder 423. The specific pressing position of the clamping component 400 and the transdermal drug delivery component 500 is determined according to the patient's own feeling.

[0060] The pyramidal tip of the silicone micro-convex 521 generates a certain pressure on the skin surface, forcing the lipid bilayer of the stratum corneum to undergo shear slippage, forming loosened pores with a gradient distribution of pore size. The pore size is further expanded by stratum corneum softening enzymes, thereby improving the efficiency of targeted drug transdermal delivery.

[0061] Air pump 514 injects compressed air into the air chamber of conical upper cylinder 5111, pushing partition plate 512 to move towards lower cylinder 5112, squeezing the compound Chinese medicine extract in the liquid chamber. The liquid flows out evenly through the guide hole 5113 of lower cylinder 5112, and passes through filter membrane 5222 and drug-loaded membrane 5223 in sequence, achieving effective and rapid drug permeation.

[0062] The telescopic frame pressure plate 533 automatically adapts to different body surface curvatures through the nesting and telescopic movement of the upper frame pressure strip 5331 and the lower frame pressure strip 5332. The telescopic pressure rod 534 is linked with the frame pressure plate 533, adjusting the pressure distribution in real time when the patient's position changes, ensuring that the pressure of the multiple silicone micro-protrusions 521 pressing against the skin surface is consistent, preventing excessive compression, and at the same time creating more effective channels to improve drug permeability.

[0063] When the temperature sensor 543 detects that the skin surface temperature is too high, the controller controls the output end of the cylinder 310 to move upward, so that the clamping component 400 and the transdermal drug delivery component 500 move upward. The vacuum adsorption strip 5312 is adsorbed onto the skin surface, and the telescopic frame bar pressure plate 533 and the telescopic pressure rod 534 are passively extended. The upward-moving lower cylinder 5112 and the outer armature plate 513 pull the middle plate 522 through the telescopic frame bar pressure plate 533 and the telescopic pressure rod 534, so that the silicone micro-protrusion 521 reduces the pressure on the skin surface. Secondly, the distance between the outer armature plate 513 and the middle plate 522 increases, and the two rectangular plates 541 are respectively installed in the L-shaped grooves of the outer armature plate 513 and the middle plate 522. The two rectangular plates 541 are flipped by the pull of the connecting rod 542, and the hot air exchanges airflow with the outside through the L-shaped groove.

[0064] After the preset drug administration time is completed, the edge of the vacuum adsorption strip 5312 is moved to detach it from the skin surface. The controller controls cylinder 310 to drive the clamping component 400 and the transdermal drug delivery component 500 to continue moving upward to a certain position. Cylinder 431 pulls the drive ring 432 upward, which drives the outer pressure cylinder 423 to rise through the linkage rod 424. The gripper 425 simultaneously unfolds along the mounting groove of the inner connecting cylinder 422, releasing the transdermal drug delivery component 500. Cylinder 310 drives the actuator plate 320 upward, and the rotating arm assembly 200 is manually pushed to automatically reset to the initial position, completing the entire drug administration cycle.

[0065] Of course, the above description is merely a preferred embodiment of this application and should not be considered as limiting the scope of the embodiments of this application. This application is also not limited to the examples above, and all equivalent changes and improvements made by those skilled in the art within the scope of this application should fall within the patent coverage of this application.

[0066] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.

[0067] Secondly: The accompanying drawings of the embodiments disclosed in this application only involve the structures involved in the embodiments disclosed in this application. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this application can be combined with each other.

[0068] Finally: The above are merely preferred embodiments of this application and are not intended to limit this application. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A targeted transdermal application device for traditional Chinese medicine, characterized in that, include: A base (100) is connected to a rotating arm assembly (200); The upper and lower telescopic component (300) has a fixed end of the rotating arm assembly (200), which achieves horizontal rotation through the rotating arm assembly (200); The clamping component (400) is suspended on the upper and lower telescopic component (300), and the clamping range of the clamping component (400) is adjusted by extending and retracting the upper and lower telescopic component (300); A transdermal drug delivery component (500) is held by a clamping component (400) and pressed against the back of a patient. The transdermal drug delivery component (500) includes a drug delivery component (510) and a dressing component (520). The drug delivery component (510) presses and delivers the drug to the dressing component (520). The dressing component (520) includes an intermediate plate (522) and a plurality of pyramid-shaped silicone micro-protrusions (521) arranged in an array on the surface of the intermediate plate (522). The upper and lower telescopic component (300) extends and retracts to transmit force to the drug delivery component (510) so that the silicone micro-protrusions (521) are pressed and thus closely adhere to the skin surface, so that the lipid arrangement of the stratum corneum of the skin surface is loosened to form a "honeycomb" pore.

2. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 1, characterized in that: The silicone micro-protrusion (521) includes a shell layer (5211), and micro-protrusions (5214) are provided on multiple sides of the shell layer (5211). The tip of the shell layer (5211) and the micro-protrusions (5214) are coated with keratin softening enzyme.

3. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 2, characterized in that: The drug delivery component (510) includes a drug delivery cylinder (511) and an outer connecting plate (513). The outer connecting plate (513) is connected to the outer side of the bottom end of the drug delivery cylinder (511). The drug delivery component (510) also includes an air pump (514) and an air tube (515). The air tube (515) is connected to the air outlet of the air pump (514). Air is introduced and discharged through the air pump (514) to squeeze the drug liquid in the drug delivery cylinder (511) and discharge it.

4. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 3, characterized in that: The transdermal drug delivery component (500) further includes a pressure-seal assembly (530) and a heat-releasing assembly (540). The pressure-seal assembly (530) includes a first pressure-seal component (531) and a second pressure-seal component (532). The first pressure-seal component (531) and the second pressure-seal component (532) are respectively disposed on both sides of the intermediate plate (522). The first pressure-seal component (531) is used to seal the gap between the intermediate plate (522) and the skin surface. The second pressure-seal component (532) is used to seal the gap between the intermediate plate (522) and the outer connecting plate (513). The surface of the intermediate plate (522) is provided with a plurality of rectangular through grooves (5221) arranged in an array. The plurality of rectangular through grooves (5221) correspond to the plurality of silicone micro-protrusions (521).

5. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 4, characterized in that: Each rectangular slot (5221) of the intermediate plate (522) is provided with a filter membrane (5222) and a drug-loaded membrane (5223), wherein the drug-loaded membrane (5223) is disposed on the side of the rectangular slot (5221) near the silicone micro-protrusion (521); both the filter membrane (5222) and the drug-loaded membrane (5223) are designed with a multi-layer structure.

6. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 5, characterized in that: The first pressure-distributing component (531) includes a lower silicone strip (5311) and a vacuum adsorption strip (5312) connected to the surface of the lower silicone strip (5311). The lower silicone strip (5311) forms a frame structure to enclose the lower surface of the intermediate plate (522). The second pressure-distributing component (532) includes an upper silicone strip (5321) and a frame plate (5322) connected to the surface of the upper silicone strip (5321). The frame plate (5322) is connected to the outer mounting plate (513) through the upper silicone strip (5321).

7. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 6, characterized in that: The surface of the outer armature plate (513) is connected to a telescopic frame strip pressure plate (533). The telescopic frame strip pressure plate (533) includes an upper frame pressure strip (5331) and a lower frame pressure strip (5332). The upper frame pressure strip (5331) is engaged and moved within the inner cavity of the lower frame pressure strip (5332) to adjust the length of the telescopic frame strip pressure plate (533). The bottom of the outer armature plate (513) and the lower cylinder of the disc (5112) is provided with multiple telescopic pressure rods (534). The telescopic pressure rods (534) and the telescopic frame strip pressure plate (533) extend and retract synchronously.

8. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 7, characterized in that: The minimum height at which the retractable pressure bar (534) and the retractable frame plate (533) retract is the superimposed height of the upper silicone strip (5321) and the frame plate (5322).

9. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 8, characterized in that: The heat release assembly (540) includes two rectangular plates (541) and a connecting rod (542), the two rectangular plates (541) being connected by the connecting rod (542).

10. The targeted transdermal drug delivery device for traditional Chinese medicine as described in claim 9, characterized in that: The telescopic component (300) includes a cylinder (310) and an actuator plate (320). The cylinder (310) is mounted on the rotating arm assembly (200), and the actuator plate (320) is fixed to the bottom of the cylinder (310). L-shaped grooves are provided at the relative positions of the outer connecting plate (513) and the intermediate plate (522). The two rectangular plates (541) are rotatably connected in the L-shaped grooves. A temperature sensor (543) is provided on the outer connecting plate (513). A controller is provided on the cylinder (310). When the temperature sensor (543) detects that the temperature of the transdermal drug leakage site has increased, the controller controls the output end of the cylinder (310) to move upward.

Images