Detection instrument

Abstract

The invention discloses a detection instrument which comprises a reaction unit and a pipetting unit, and a plurality of reaction positions for containing a first substance are arranged in the reaction unit. And the pipetting unit is arranged to move relative to the reaction unit so as to convey a second substance into the plurality of reaction positions.

Description

Technical Field

[0001] The present invention relates to the technical field of detection equipment, and in particular to a detection instrument. Background Art

[0002] Testing instruments require the mixing of at least two reactants, typically requiring multiple tests. For example, a home urine tester includes a reagent cartridge containing multiple reagents. These reagents are drawn into a common flow channel, mixed with the sample, and then tested.

[0003] However, after the reagents and samples are mixed, they will contaminate the common flow channel, affecting the next use. Cleaning equipment is also required for cleaning. The manufacturing cost of the entire device is relatively high, and the precise quantity of reagents extracted each time makes the manufacturing of the equipment somewhat difficult. Summary of the Invention

[0004] The purpose of the present invention is to provide a detection instrument to solve the problems of the prior art.

[0005] In order to solve the above technical problems, an embodiment of the present invention provides a detection instrument, which includes:

[0006] A reaction unit, wherein the reaction unit is provided with a plurality of reaction positions for containing the first substance;

[0007] The pipetting unit is configured to be movable relative to the reaction unit to transport the second substance into the plurality of reaction sites.

[0008] In one embodiment, the pipetting unit is configured to be capable of relative translational movement with respect to the reaction unit.

[0009] In one embodiment, the pipetting unit is configured to be rotatable relative to the reaction unit.

[0010] In one embodiment, the pipetting unit is configured to be capable of swinging relative to the reaction unit.

[0011] In one embodiment, the pipetting unit is configured to be capable of relative translation, rotation, or swinging, or a combination thereof, with the reaction unit.

[0012] In one embodiment, the detection instrument further comprises a main body unit;

[0013] The reaction unit and the main body unit are rotatably connected around a vertical axis;

[0014] The plurality of reaction sites are arranged at intervals along the circumference of the reaction unit.

[0015] In one embodiment, the detection instrument further comprises a mounting base and a first driving unit;

[0016] The first driving unit is connected to the main body unit;

[0017] The mounting seat is connected to the output shaft of the first driving unit;

[0018] The reaction unit is detachably connected to the mounting seat.

[0019] In one embodiment, the detection instrument further includes a quick-release part, which is connected to the mounting base and can be switched between a first state, a second state, and a third state. In the first state, the quick-release part restricts the reaction unit from being separated from the mounting base; in the second state, the reaction unit can be removed from the mounting base or installed on the mounting base; in the third state, the reaction unit is separated from the mounting base.

[0020] In one embodiment, a mounting groove is provided on the side of the mounting seat;

[0021] The detection instrument also includes:

[0022] a limiting member connected to an inner wall of the mounting groove and rotatable between a first state, a second state, and a third state, wherein in the first state, an outer end of the limiting member is located outside the mounting seat and abuts against the reaction unit; and in the second state and the third state, the outer end of the limiting member is located within the mounting groove;

[0023] A first restoring member is connected to the limiting member or the mounting seat and is used to drive the outer end of the limiting member to rotate toward the outside of the mounting groove.

[0024] In one embodiment, a rotating shaft is installed in the installation slot;

[0025] The inner end of the limiting member is rotatably connected to the rotating shaft;

[0026] The first restoring member is an elastic member installed on the rotating shaft, one end of the elastic member is fixedly connected to the limiting member, and the other end abuts against the inner wall of the installation groove.

[0027] In one embodiment, the limiting member includes a pressing surface and a limiting surface that are adjacent to each other, and the corners of the pressing surface and the limiting surface are the outer ends of the limiting member;

[0028] In the first state, the distance between the limiting surface and the mounting seat gradually increases from the bottom end to the top end, and the pressing surface is a horizontal surface.

[0029] In one embodiment, the mounting groove opens toward the top surface of the mounting seat;

[0030] The limiting member includes a pressing portion, the pressing portion is movably connected to the mounting seat along a vertical direction, and the bottom end of the pressing portion abuts against the pressing surface.

[0031] In one embodiment, the pressing portion is elastically connected to the mounting seat.

[0032] In one embodiment, the mounting seat is provided with a support surface, and a first elastic member is provided on the top surface of the support surface;

[0033] The reaction unit is located on the top surface of the first elastic member;

[0034] In the first state, the bottom surface of the reaction unit presses the first elastic member.

[0035] In one embodiment, the radial inner side of the reaction unit is cylindrical, and at least two areas of the radial inner side of the reaction unit have different distances from the center;

[0036] The radially outer shape of the mounting seat complements the radially inner shape of the reaction unit.

[0037] In one embodiment, the pipetting unit comprises:

[0038] transfer device; and

[0039] An insertion needle is movably connected to the transfer device and has a head end and a tail end, the head end is provided with a needle tip and can be moved into or out of the reaction position, and the tail end is connected to the collection chamber containing the second substance.

[0040] In one embodiment, the transfer device is provided with a moving channel, the two ends of the moving channel are respectively a first opening and a second opening, and the first opening is aligned with the reaction position;

[0041] The insertion pin is movably installed in the movable channel, with the head end of the insertion pin located at the first opening and the tail end located at the second opening.

[0042] In one embodiment, the reaction site is a cavity having a top opening;

[0043] The transfer device is located above the reaction unit;

[0044] The movable channel extends in a vertical direction, the first opening is located at the bottom end of the movable channel, and the second opening is located at the top end of the movable channel;

[0045] The insertion pin is installed in the movable channel in a vertically movable manner, and the head end of the insertion pin can be moved into or out of the reaction position from the top opening of the reaction position.

[0046] In one embodiment, a second driving unit is further provided in the movable channel, and the second driving unit is connected to the insertion pin and can operably drive the insertion pin to move in a vertical direction.

[0047] In one embodiment, the second driving unit includes:

[0048] a magnet connected to the pin;

[0049] A coil is connected to the moving channel.

[0050] In one embodiment, the moving unit further comprises a moving block, and the moving block is located in the moving channel;

[0051] The pin and the magnet are both connected to the moving block.

[0052] In one embodiment, the second opening is located on the top side of the transfer device;

[0053] The moving block is provided with an L-shaped transfer cavity, one end of which is open toward the bottom end of the moving block and is used to install the tail end of the pin; the other end of the transfer cavity is open toward the side of the moving block and is aligned with the second opening and is used to install the transfer tube;

[0054] The adapter tube is connected to the tail end of the pin to communicate with the collection cavity;

[0055] The magnet is connected to the top end of the moving block;

[0056] The coil is connected to the top wall of the moving channel.

[0057] In one embodiment, the detection instrument further comprises a pump or a piezoelectric micropump, wherein the pump or the piezoelectric micropump is connected to the transfer tube and is used to drive the second substance into the reaction site.

[0058] In one embodiment, the pipetting unit further includes a second elastic member installed in the moving channel and operable to drive the insertion pin to move upward.

[0059] In one embodiment, the moving channel includes a first section, a second section, and a third section arranged in sequence from the top end to the bottom end and connected to each other;

[0060] The first section is provided with the second opening;

[0061] The third section has the first opening;

[0062] The width of the first segment is greater than the width of the second segment, and the width of the second segment is greater than the width of the third segment;

[0063] The movable block is movably mounted in the first section, and the coil is mounted on the top wall of the first section;

[0064] The top end of the second elastic member is located in the first section and connected to the moving block, and the bottom end is located in the second section and connected to the bottom wall of the bottom end.

[0065] In one embodiment, the reaction unit is detachably connected to the main body unit;

[0066] The pipetting unit is rotatably connected to the main body unit around a horizontal axis. The pipetting unit can rotate between a first position and a second position. In the first position, the pipetting unit can transport the second substance into the reaction site; in the second position, the reaction unit can be removed from or installed on the main body unit.

[0067] In one embodiment, the reaction unit and the main body unit are detachably connected in a vertical direction;

[0068] The pin is connected to the transfer device so as to be movable along the vertical direction;

[0069] In the first position, the transfer device is located above the reaction position;

[0070] In the second position, the transfer device is offset from above the reaction position.

[0071] In one embodiment, the pipetting unit further comprises a rotating body, the bottom end of the rotating body is rotatably connected to the main body unit, and the top end of the rotating body is provided with a support column;

[0072] The bottom end of the transfer device is connected to the top end of the support column, and the bottom wall of the transfer device, the side wall of the support column and the top wall of the rotating body form a U-shaped groove;

[0073] In the first position, the reaction site is located in the U-shaped groove;

[0074] In the second position, the reaction site is located outside the U-shaped groove.

[0075] In one embodiment, the bottom wall of the transfer device is further mounted with a first roller;

[0076] The top wall of the rotating body is further provided with a second roller;

[0077] The radial outer side of the reaction unit is located in the U-shaped groove.

[0078] In one embodiment, the pipetting unit further includes a third driving unit, wherein the third driving unit is connected to the main body unit and the rotating body, and is configured to drive the rotating body to rotate from the second position to the first position.

[0079] In one embodiment, the third driving unit is two magnetic members attracted to each other.

[0080] In one embodiment, the pipetting unit further includes a fourth driving unit, wherein the fourth driving unit is connected to the main body unit and the rotating body, and is configured to drive the rotating body to rotate from the first position to the second position.

[0081] In one embodiment, the main body unit comprises:

[0082] a bottom plate, the rotating body being rotatably connected to the bottom plate; and

[0083] Two side plates, the two side plates are respectively located on both sides of the rotating body;

[0084] The third driving unit is connected to one of the side plates, and the fourth driving unit is connected to the other side plate.

[0085] In one embodiment, the reaction unit comprises:

[0086] A reagent tray, wherein the reagent tray is provided with a plurality of the reaction sites, and the top openings of the plurality of the reaction sites are located on the top surface of the reagent tray; and

[0087] a sealing film, the sealing film being sealingly connected to the top surface of the reagent disk and sealing the top opening of the reaction site;

[0088] The head end of the insertion needle can pierce the sealing membrane and move into or out of the reaction site through the top opening of the reaction site.

[0089] In one embodiment, the reaction site is provided with a window open toward the radially outer side of the reagent disk;

[0090] The reaction unit further includes a side cover, which is made of a light-transmitting material and covers the window;

[0091] The detection instrument further comprises an analysis unit;

[0092] The windows of a plurality of the reaction sites are operably aligned with the analysis unit.

[0093] In one embodiment, the analysis unit is connected to the support column;

[0094] The first substance is a plurality of test papers;

[0095] In the first position, a plurality of the test strips are operably aligned with the analyzing unit.

[0096] In one embodiment, a mounting plate is provided in the reaction position, and a groove for the test paper is provided on the outside of the mounting plate; the top of the mounting plate is aligned with the top opening of the reaction position and is provided with a guide structure, and the guide structure is connected to the groove.

[0097] In one embodiment, the detection instrument further includes a data processing unit, which is connected to the analysis unit and is used to receive and analyze data from the analysis unit.

[0098] In the detection instrument of the present invention, the reaction unit and the pipetting unit move relative to each other. The sample only needs to be sent to the reaction position of the reaction unit to react with the test paper or a quantitative reagent. Since multiple reaction positions are set, multiple tests can be performed without the need to clean the equipment, and the detection accuracy can also be guaranteed. BRIEF DESCRIPTION OF THE DRAWINGS

[0099] Figure 1 and Figure 2 It is a perspective view of an inspection instrument according to one embodiment of the present invention.

[0100] Figure 3 yes Figure 1 Exploded view of the detection instrument in the illustrated embodiment.

[0101] Figure 4 yes Figure 1 Assembly diagram of the mounting base and quick release member in the illustrated embodiment.

[0102] Figure 5 yes Figure 4 A cross-sectional view of the mounting base and quick release member along line AA in the illustrated embodiment.

[0103] Figure 6 、 Figure 7 and Figure 8 They are Figure 4 Exploded view of the mounting base and quick release assembly in the illustrated embodiment.

[0104] Figure 9 yes Figure 1 Exploded view of the reaction unit in the illustrated embodiment.

[0105] Figure 10 yes Figure 9 A perspective view of the mounting plate in the illustrated embodiment.

[0106] Figure 11 yes Figure 1 Exploded view of the detection instrument in the illustrated embodiment.

[0107] Figure 12 yes Figure 1 Exploded view of the pipetting unit and the main body unit in the illustrated embodiment.

[0108] Figure 13 yes Figure 1 Assembly diagram of the main unit and pipetting unit in the illustrated embodiment.

[0109] Figure 14 Figure 1 A perspective view of the transfer device of the illustrated embodiment.

[0110] Figure 15 yes Figure 14 A cross-sectional view along line BB of the transfer device, the pin, the moving block and the second elastic member after assembly in the illustrated embodiment.

[0111] Figure 16 yes Figure 1 A perspective view of the transfer device of the illustrated embodiment.

[0112] Figure 17 yes Figure 16 A cross-sectional view of the transfer device along line CC in the illustrated embodiment.

[0113] Figure numerals: 100, detection instrument; 1, main unit; 11, bottom plate; 12, first side plate; 13, second side plate; 2, reaction unit; 21, reagent disk; 22, sealing film; 23, mounting plate; 24, flow guide structure; 25, cavity; 26, top opening; 27, side cover; 28, test paper; 3, analysis unit; 4, pipetting unit; 41, transfer device; 411, moving channel; 412, first opening; 413, second opening; 414, first section; 415, second section; 416, third section; 42, pin; 421, head end; 422, tail end; 43, moving block; 431, transfer cavity; 44, magnet; 45, coil; 46, transfer tube; 47, second elastic member; 48, rotating body; 481, support column; 482, U-shaped groove; 483, first roller; 484, second roller; 491, first N-shaped magnetic block; 492, first S-shaped magnetic block; 493, second N-shaped magnetic block; 494, second S-shaped magnetic block; 5, first driving unit; 6, mounting seat; 61, prism; 611, mounting groove; 62, support plate; 621, support surface; 63, cover plate; 631, first avoidance hole; 632, second avoidance hole; 633, third avoidance hole; 64, first elastic member; 7, quick release member; 71, rotating shaft; 72, limiting member; 721, pressing surface; 722, limiting surface; 723, first corner; 724, second corner; 73, first reset member; 74, pressing portion; 741, top plate; 742, presser foot; 743, countersunk hole; 744, shoulder screw; DETAILED DESCRIPTION

[0114] To make the objectives, technical solutions, and advantages of the present invention more apparent, various embodiments of the present invention will be described in detail below with reference to the accompanying drawings. However, those skilled in the art will appreciate that many technical details are provided in various embodiments of the present invention to facilitate a better understanding of the present application. However, even without these technical details and the various variations and modifications based on the following embodiments, the technical solutions claimed in the claims of this application can be implemented.

[0115] Unless the context requires otherwise, throughout the specification and claims, the word "comprise" and variations such as "include" and "have" should be construed in an open, inclusive sense, that is, should be interpreted to mean "including, but not limited to."

[0116] The following will describe in detail various embodiments of the present invention in conjunction with the accompanying drawings to provide a clearer understanding of the objectives, features and advantages of the present invention. It should be understood that the embodiments shown in the accompanying drawings are not intended to limit the scope of the present invention, but are only intended to illustrate the essential spirit of the technical solution of the present invention.

[0117] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any manner in one or more embodiments.

[0118] As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. It should be noted that the term "or" is generally employed in its sense including "and / or" unless the context clearly dictates otherwise.

[0119] In the following description, in order to clearly show the structure and working mode of the present invention, many directional words will be used for description, but words such as "front", "back", "left", "right", "outside", "inside", "outward", "inward", "up", and "down" should be understood as convenient terms and should not be understood as restrictive terms.

[0120] The present invention relates to a detection instrument 100, which includes a main unit 1, a reaction unit 2, an analysis unit 3 and a pipetting unit 4, wherein the main unit 1 is used to accommodate the reaction unit 2, the analysis unit 3 and the pipetting unit 4, and the reaction unit 2 is provided with multiple reaction sites for holding a first substance. The pipetting unit 4 is used to transfer a second substance to the reaction site of the reaction unit 2 to facilitate the reaction of the second substance with the first substance, and the analysis unit 3 is used to optically detect the reaction between the first substance and the second substance.

[0121] The second substance can be one or more of a urine sample, a blood sample, a buffer, a cleaning solution, a catalyst, a marker, and the like. The first substance can be a reagent that reacts with the sample, multiple test strips 28 that react with the sample, or another reagent that reacts with the reagent within the aforementioned reaction site. In other words, the detection instrument 100 can be used to detect the product of the reaction between the sample and the reagent, or it can be used for reactions involving two or more reagents. This detection instrument is not only suitable for urine testing, but can also be used for blood testing, environmental water sample testing, food safety testing, and the like.

[0122] exist Figure 1 and Figure 2 In the illustrated embodiment, the detection instrument 100 is a urine test instrument, the second substance is a test paper 28 or a reagent, and the first substance is a sample, that is, urine.

[0123] by Figure 1 and Figure 2 In this embodiment, the main unit 1 of the detection instrument 100 includes at least a bottom plate 11 , and the bottom plate 11 is used to install the reaction unit 2 and the pipetting unit 4 .

[0124] In which, the reaction unit 2 is rotatably connected to the base plate 11 of the main unit 1 through a driving unit, and the driving unit is defined as a first driving unit 5. The first driving unit 5 is a motor, and its output shaft can rotate around a vertical axis. That is to say, the reaction unit 2 can be rotated around a vertical axis through the first driving unit 5.

[0125] The motor is fixedly connected to the base plate 11, and the motor's output shaft is fixedly connected to a mounting base 6. This mounting base 6 is used to mount the reaction unit 2, facilitating disassembly and assembly of the reaction unit 2. The reaction unit 2 is a consumable item. After the test strips 28 or reagents in the multiple reaction positions 25 within the reaction unit 2 are used up, they can be removed from the mounting base 6 and replaced with a new reaction unit 2. The mounting base 6 is mainly used to facilitate the rapid disassembly or assembly of the reaction unit 2.

[0126] like Figure 3 and Figure 4 As shown, the mounting base 6 includes a prism 61 and a support plate 62 that fits over the outside of the prism 61. The prism 61 is a hexagonal prism, but it can also be a quadrangular prism, a pentagonal prism, or other prisms. The support plate 62 is annular and located at the bottom end of the prism 61. The top surface of the support plate 62 serves as a support surface 621. The reaction unit 2 is a columnar structure that fits radially outwardly of the prism 61 and is located on top of the support surface 621. In other words, the support surface 621 is used to support the reaction unit 2, as will be described in detail below.

[0127] The center of the prism 61 is connected to the outside of the output shaft of the motor and is fixedly connected to the output shaft, while a quick-release part 7 is provided on the radial outer side.

[0128] The quick release member 7 is connected to the mounting base 6 and can be switched between a first state, a second state, and a third state. In the first state, the quick release member 7 can restrict the reaction unit 2 from being separated from the mounting base 6. In the second state, the quick release member 7 is separated from the reaction unit 2, and the reaction unit 2 can be removed from or installed on the mounting base 6. In the third state, the reaction unit 2 is separated from the mounting base 6.

[0129] exist Figure 5 In the specific embodiment shown, two mounting grooves 611 are provided on the radial outer side of the prism 61, and the two quick-release parts 7 are respectively located in the two mounting grooves 611. Since the structures of the two quick-release parts 7 and the assembly methods with the inner walls of the mounting grooves 611 are the same, one of the quick-release parts 7 and the mounting groove 611 is taken as an example.

[0130] The mounting groove 611 is open radially outward from the prism 61. The quick-release member 7 includes a rotating shaft 71, a stopper 72, a first return member 73, and a pressing portion 74. The rotating shaft 71 is fixed to the inner wall of the mounting groove 611, while the stopper 72 is located within the mounting groove 611 and connected to the rotating shaft 71. Alternatively, the rotating shaft 71 can be rotatably connected to the inner wall of the mounting groove 611 while the stopper 72 is fixedly connected to the rotating shaft 71. As long as the rotating shaft 71 is rotatable, any of the above arrangements will be acceptable.

[0131] The pressing portion 74 is disposed at the top end of the prism 61 , and the limiting member 72 is driven to move toward the installation groove 611 by the pressing portion 74 .

[0132] Specifically, if Figure 6 and Figure 7 As shown, the mounting groove 611 extends to the top surface of the prism 61 and opens toward the top surface of the prism 61. A cover plate 63 is provided on the top surface of the prism 61, and the cover plate 63 covers the top surface of the prism 61 and is movable in the vertical direction.

[0133] The cover plate 63 is provided with a first avoidance hole 631, two second avoidance holes 632 and multiple third avoidance holes 633. The first avoidance hole 631 is close to the center of the cover plate 63, and the two second avoidance holes 632 are aligned with the two mounting grooves 611 in the vertical direction respectively. The multiple third avoidance holes 633 can be evenly distributed on the periphery of the cover plate 63 or scattered on the cover plate 63, without limiting the specific position of the third avoidance holes 633.

[0134] The pressing portion 74 includes a top plate 741 and a presser foot 742 connected to the bottom end of the top plate 741. The top plate 741 is located above the cover plate 63 and is provided with a countersunk hole 743. Figure 8As shown, the countersunk hole 743 is aligned with the first avoidance hole 631, the head of the shoulder screw 744 is located in the countersunk hole, and the smooth shaft of the shoulder screw 744 passes through the countersunk hole 743 and the first avoidance hole 631, and is threadedly connected to the prism 61. It should be understood that the shoulder screw 744 does not lock the top plate 741 and the cover plate 63. After the screw and the prism 61 are fixedly connected, the top plate 741 can still move in the vertical direction.

[0135] The top ends of the springs are respectively connected to the bottom surface of the top plate 741 , and the bottom ends pass through the third avoidance holes 633 and are fixedly connected to the prism 61 . The springs can push the top cover to move upward.

[0136] The two presser feet 742 are respectively connected to the top surface of the top plate 741. The bottom ends of the two presser feet 742 pass through the two second avoidance holes 632 and enter the installation slot 611. They respectively press against the pressing surfaces 721 of the two limit members 72 in the two installation slots 611. Pressing the top plate 741 drives the two presser feet 742 downward, and the two presser feet 742 drive the limit members 72 to rotate toward the interior of the installation slot 611, facilitating the removal or installation of a new reaction unit 2.

[0137] Of course, in other embodiments, the cover plate 63 may not be provided, and the pressing portion 74 may be elastically connected to the top surface of the prism 61 via several springs, which can also achieve the above-mentioned effect.

[0138] The support surface 621 is provided with a plurality of first elastic members 64. The first elastic members 64 are springs, with their bottom ends connected to the support surface 621 and their top ends suspended above the support surface 621. In the first state, i.e., after the reaction unit 2 is mounted on the prism 61, the outer end of the stopper 72 is located outside the mounting base 6 and abuts the top end of the reaction unit 2. Specifically, the reaction unit 2 is located between the support plate 62 and the stopper 72. The bottom end of the reaction unit 2 presses against the first elastic members 64, while the top end abuts against the stopper 72, clamping the reaction unit 2, making it more stable and preventing it from separating from the prism 61.

[0139] In the second state, the pressing portion is pressed downward to retract the outer end of the limiting member 72 into the installation groove 611, and the reaction unit 2 can be moved upward to be removed from the prism 61, or a new reaction unit 2 can be installed outside the prism 61 from top to bottom.

[0140] In the third state, the pressing portion is released, the outer end of the limiting member 72 is located at the outer end of the mounting groove 611 , the reaction unit is completely separated from the mounting seat, and the first elastic member 64 is in a natural state.

[0141] The first restoring member 73 is connected to the limiting member 72 or the mounting seat 6 and is used to drive the outer end of the limiting member 72 to rotate toward the outside of the mounting groove 611. That is, in the first state, the first restoring member 73 can push the outer end of the limiting member 72 to rotate toward the outside of the prism 61, so that the outer end of the limiting member 72 squeezes the top of the reaction unit 2. External force acts on the limiting member 72, causing the limiting member 72 to resist the force of the first restoring member 73 and retract into the mounting groove 611, so that the reaction unit 2 can be removed from or installed on the prism 61.

[0142] In one embodiment, Figure 5 As shown, the limiting member 72 is in the shape of a triangular prism, one of the corners of which is located in the mounting groove 611 and connected to the rotating shaft 71, and is defined as the first corner 723, and the other corner can be rotated to the outside of the prism body 61, and is defined as the second corner 724.

[0143] The radial outer side of the triangular prism has three surfaces, and the two surfaces forming the second corner 724 are defined as a pressing surface 721 and a limiting surface 722 .

[0144] In an optional embodiment, in the first state, the pressing surface 721 is located on the top surface of the limiting surface 722 and is an inclined surface that gradually moves away from the radially outer side of the prism 61 from top to bottom. That is, the distance between the pressing surface 721 and the prism 61 gradually increases from top to bottom. When the reaction unit 2 is installed, its bottom end abuts against the pressing surface 721, driving the limiting member 72 to rotate toward the installation groove 611. When the second corner 724 of the limiting member 72 is fully rotated into the installation groove 611, the reaction unit 2 is inserted into the outside of the prism 61. Then, the limiting member 72 is driven by the first return member 73 to rotate from the installation groove 611 to the outside of the prism 61. The limiting surface 722 abuts against the top of the reaction unit 2, locking the reaction unit 2.

[0145] In another embodiment, in the first state, the distance between the limiting surface 722 and the radial outer side of the prism 61 gradually increases from bottom to top, and the limiting surface 722 is also an inclined surface. When the reaction unit 2 needs to be disassembled, the operator moves the reaction unit 2 from bottom to top, and the top end of the reaction unit 2 drives the limiting member 72 to move toward the installation groove 611 through the limiting surface 722. After the second corner 724 of the limiting member 72 is completely rotated into the installation groove 611, the reaction unit 2 can be disassembled from the prism 61.

[0146] In other optional embodiments, the pressing surface 721 or the limiting surface 722 may also be an arc surface. When the pressing surface 721 and the limiting surface 722 are both arc surfaces, the second corner 724 formed by the pressing surface 721 and the limiting surface 722 is not obvious, but does not affect the movement of the limiting reaction unit 2.

[0147] exist Figure 6 and Figure 7In the embodiment shown, the triangular prism is a regular triangular prism, that is, the three corners of the triangular prism are basically the same. In the first state, the distance between the limiting surface 722 and the radial outer side of the prism body 61 gradually increases from bottom to top, and the pressing surface 721 is a horizontal plane.

[0148] The first reset member 73 is an elastic member installed on the rotating shaft 71, which is a torsion spring. One end of the torsion spring is fixedly connected to the limiting member 72, and the other end abuts against the inner wall of the installation groove 611. The torsion spring can drive the second edge 724 of the limiting member 72 to move toward the outside of the installation groove 611.

[0149] The reaction unit 2 includes a reagent disk 21 , a mounting plate 23 , a side cover 27 and a sealing membrane 22 . As a preferred embodiment, the radially inner hole of the reagent disk 21 is hexagonal, and the radially outer side surface is cylindrical.

[0150] The shape of the radial inner side of the reagent disk 21 complements the shape of the radial outer side of the mounting seat 6, so that the mounting seat 6 can drive the reaction unit 2 to rotate around the vertical axis. It should be understood that in other embodiments, the reaction unit 2 can also be directly connected to the output shaft of the motor.

[0151] It can be understood that the radial outer side of the mounting seat 6 can also be other polygonal columns, and the mounting seat 6 can also be a cylinder, but at least one part of the cylinder is provided with a ridge extending in the vertical direction or a notch extending in the vertical direction, that is, in the radial outer side of the mounting seat 6, at least two areas are at different distances from its center, and the radial inner side of the reagent disk 21 is complementary to the radial outer side of the mounting seat 6, that is, at least two areas on the radial inner side of the reagent disk 21 are at different distances from the center, thereby preventing the mounting seat 6 from rotating alone relative to the reagent disk 21.

[0152] In the embodiment shown in the figure, the plurality of reaction sites are cavities 25. It should be understood that in other embodiments, the reaction sites may also be holes, grooves or other micro-reaction units.

[0153] The plurality of cavities 25 are evenly arranged along the circumference of the reagent disc 21 and are formed by depressions on the radial outer side of the reagent disc 21, as shown in FIG. Figure 9 As shown, the side cover 27 is installed at the outer opening of the cavity 25 , and the side cover 27 is made of a light-transmitting material to facilitate the projection of light from the side cover 27 into the cavity 25 .

[0154] Multiple mounting plates 23 are respectively installed in multiple cavities 25. Each mounting plate 23 is provided with a groove and a guide structure 24. The groove faces the outside of the mounting plate 23 and is arranged corresponding to the side cover 27 for installing the test paper 28. Figure 10As shown, the guide structure 24 is aligned with the top opening 26 of the wall at the top of the mounting plate 23. The guide structure 24 serves as a flow channel that connects to the groove, with the inner wall width gradually increasing from top to bottom. The sample enters the flow channel through the top opening 26 of the cavity 25 and flows along the guide structure 24 to the test paper 28 in the groove, ensuring that the entire sample flows into the test paper 28, avoiding waste.

[0155] The pipetting unit 4 is connected to the base plate 11 and is used to deliver samples into the multiple cavities 25 of the reaction unit 2. Therefore, it can be understood that relative movement between the pipetting unit 4 and the reaction unit 2 can accomplish sample delivery into the multiple cavities 25. If the reaction unit 2 is fixedly connected to the base plate 11, the pipetting unit 4 can also move relative to the reaction unit 2 to deliver samples into the multiple cavities 25. For example, the pipetting unit can be configured to translate relative to the reaction unit, and the reaction disk is configured in a strip shape, with the multiple cavities 25 spaced apart along the length of the reaction disk. The pipetting unit 4 can then move along the length of the reaction disk to deliver samples into the multiple cavities 25.

[0156] In another embodiment, the reaction unit is also cylindrical and hollow, with multiple reaction sites arranged circumferentially. The pipetting unit can be set at the center of the reaction unit and configured so that the reaction unit can rotate relatively. For example, the pipetting unit can rotate around a vertical axis. During the rotation of the pipetting unit, the second substance can be transported to the multiple reaction sites.

[0157] In another embodiment, the pipetting unit is rotatably connected to the main unit, and the reaction unit is rotatably connected to the main unit around a vertical axis. The reaction position of the pipetting unit that moves away from or close to the reaction unit during the swinging process is configured to swing relative to the reaction unit.

[0158] Of course, in some embodiments, the pipetting unit can be configured to move along a horizontal axis. When testing is required, the pipetting unit approaches the reaction unit, which then rotates about a vertical axis. During the rotation of the reaction unit, the multiple reaction sites gradually approach the pipetting unit, facilitating the pipetting unit to transfer the second substance to the multiple reaction sites. When the reaction unit needs to be disassembled, the pipetting unit is moved along the horizontal axis and away from the reaction unit.

[0159] exist Figure 11 and Figure 12In the illustrated embodiment, the pipetting unit 4 includes a transfer device 41 and a needle 42. The transfer device 41 is provided with a vertically extending movable channel 411, with a first opening 412 and a second opening 413 at either end. The first opening 412 is located at the bottom and aligned with the top opening 26 of the cavity 25. The needle 42 is movably mounted within the movable channel 411, with the tip 421 of the needle 42 located at the first opening 412 and the tail 422 located at the second opening 413. The tail 422 of the needle 42 is configured to communicate with the sample collection chamber. The tip 421 of the needle 42 is needle-tipped, facilitating piercing the sealing membrane 22 and entering the cavity 25.

[0160] The insertion needle 42 can move in the moving channel 411 along the vertical direction. During the movement, the head end 421 of the insertion needle 42 can pierce the sealing film 22 and move into or out of the cavity 25 from the top opening 26 of the cavity 25 .

[0161] It is also understood that in other embodiments, the needle 42 can also be configured to move in the horizontal direction, and the top opening 26 of the cavity 25 is arranged on the radial outside of the reagent disk 21 and sealed with a sealing film 22. The needle 42 can penetrate into the cavity 25 through the sealing film 22 and transport the sample into the cavity 25.

[0162] exist Figure 16 and Figure 17 In the embodiment shown, the moving channel 411 extends in a vertical direction, the first opening 412 opens toward the bottom end of the moving device, and the second opening 413 is located at the side of the moving device.

[0163] The movable channel 411 includes a first section 414, a second section 415, and a third section 416, which are arranged vertically from top to bottom and communicate with each other. The second opening 413 is located in the first section 414, and the first opening 412 is located in the third section 416. The first section 414 is in the shape of a quadrangular prism, and the second section 415 and the third section 416 are both cylindrical. The width of the first section is greater than the diameter of the second section 415, and the diameter of the second section 415 is greater than the diameter of the first end.

[0164] The pipetting unit 4 further includes a moving block 43, a second driving unit and a second elastic member 47, wherein Figure 15 As shown, the moving block 43 is used to connect the pin 42 to drive the pin 42 to move in the vertical direction, the second driving unit is used to drive the moving block 43 to move in the vertical direction, and the second elastic member 47 is used to drive the moving block 43 to drive the pin 42 to move upward, that is, away from the reaction position 25.

[0165] Specifically, the moving block 43 is in the shape of a rectangular block and can be installed in the first section 414 so as to be movable in the vertical direction. The moving block 43 is provided with an L-shaped transfer cavity 431. One end of the L-shaped transfer cavity 431 is open toward the bottom end of the moving block 43 and is used to connect the tail end 422 of the pin 42. The other end of the L-shaped transfer cavity 431 is open toward the side of the moving block 43 and is aligned with the second opening 413, and is used to connect the transfer tube 46. The transfer tube 46 can also penetrate into the L-shaped transfer cavity 431 and communicate with the tail end 422 of the pin 42. The transfer tube 46 can move up and down with the moving block 43, and the second opening 413 is mainly for avoiding the transfer tube 46. The transfer tube 46 is used to communicate with the collection cavity containing the second substance, for example, with the sample collection cavity.

[0166] It should be understood that the transfer tube may be provided with a peristaltic pump, a plunger pump or a piezoelectric micro pump, and the second substance may be transported into the reaction site of the reaction unit through these pumps.

[0167] The pipetting unit 4 further includes a second elastic member 47 , which is installed in the moving channel 411 and can operably drive the insertion pin 42 to move upward.

[0168] The moving block 43 is movably installed in the first section 414; the top end of the elastic member is located in the first section 414 and connected to the moving block 43, and the bottom end is located in the second section 415 and connected to the bottom wall of the bottom end.

[0169] The second driving unit includes a magnet 44 and a coil 45, such as Figure 15 As shown, the top of the moving block 43 is provided with a slot for mounting the magnet 44, and the coil 45 is connected to the top wall of the first section 414. Of course, the magnet 44 can also be connected to the top wall of the first section 414, and the coil 45 can be wound in the slot at the top of the moving block 43, without limiting the specific implementation of the second drive unit.

[0170] The top end of the pin 42 is located in the first section 414 and inserted into the adapter cavity 431, and the bottom end extends from the second section 415 to the third section 416. As the moving block 43 moves up and down, the moving block 43 can drive the pin 42 to penetrate into the cavity 25 when moving downward, and can drive the pin 42 to move into the third section 416 when moving upward.

[0171] The second elastic member 47 is a spring that fits over the exterior of the pin 42. The top of the second elastic member 47 is connected to the top of the movable block 43, while the bottom is located within the second section 415 and connected to the bottom wall of the second section 415. The second elastic member 47 has the force to drive the pin 42 upward and away from the cavity 25. In other words, when the coil 45 is not energized, the second elastic member 47 ensures that the pin 42 does not extend outside the movable channel 411. Of course, the second elastic member 47 can also be directly mounted on the exterior of the pin 42, without being connected to the movable block 43 or the bottom wall of the second section 415, to still drive the pin 42 upward.

[0172] Since the diameter of the second section 415 is greater than the diameter of the third section 416 , the second elastic member 47 is restricted from entering the third section 416 , thereby preventing the third section 416 from escaping from the moving channel 411 .

[0173] Of course, in some embodiments, the moving device can be configured as a vertical column, with the second opening 413 located on the top surface of the transfer device 41. The coil 45 can be directly mounted on the inner wall of the movable channel 411. The magnet 44 is disposed on the outer surface of the pin 42. The coil 45 cooperates with the magnet 44 to drive the pin 42 to move vertically. Alternatively, the pin 42 can be movably connected to the transfer device 41 via a guide rail, and the specific implementation of the pin 42 and the moving device is not limited.

[0174] In some embodiments, when the reaction unit 2 does not need to be disassembled, the pipetting unit 4 can be fixedly arranged above the reaction unit 2. When the cavity 25 rotates to below the pin 42 of the pipetting unit 4, the pin 42 inputs the sample into the cavity 25. By continuously rotating the reaction unit, the sample can be input into multiple cavities 25 until the reagents or test papers 28 in all cavities 25 are used up.

[0175] In some preferred embodiments, the reaction unit 2 is configured as a disposable consumable. After each reaction unit 2 is used, it can be removed from the mounting base 6 and replaced with a new reaction unit 2. The mounting base 6, the first drive unit 5, and the pipetting unit 4 can all be reused to avoid waste.

[0176] Optionally, in order to disassemble the reaction unit 2 , the pipetting unit 4 may be disassembled first and then the reaction unit 2 , but this operation is relatively complicated and inconvenient.

[0177] To facilitate quick disassembly of the reaction unit 2, the pipetting unit 4 is preferably configured to be rotatable. The pipetting unit 4 is rotatably connected to the main unit 1 around a horizontal axis. The pipetting unit 4 can rotate between a first position and a second position. In the first position, the pipetting unit 4 can transfer the second substance into the cavity 25. In the second position, the reaction unit 2 can be disassembled and assembled from the main unit 1.

[0178] like Figure 11 and Figure 12 As shown, the pipetting unit 4 includes a rotating body 48, a supporting column 481, a third driving unit and a fourth driving unit.

[0179] The rotating body 48 is plate-shaped and its bottom end is rotatably connected to the bottom plate 11 of the main unit 1 through an axis. The support column 481 is also plate-shaped and is installed on the top surface of the rotating body 48 and deviates from the position of the reaction unit 2. The support column 481 and the rotating body 48 are integrated into an L-shape, and the top end of the support column 481 is fixedly connected to the bottom surface of the transfer device 41. The bottom wall of the transfer device 41, the side wall of the support column 481 and the top wall of the rotating body 48 cooperate to form a U-shaped groove 482.

[0180] In the first position, the rotating body 48 is in a vertical state, and the radial outer edge of the reaction unit 2 is located in the U-shaped groove 482. At this time, the transfer device 41 is located above one of the cavities 25, the cavity 25 is located in the U-shaped groove 482, and the pin 42 is facing the top opening 26 of the cavity 25.

[0181] In the second position, the rotating body 48 rotates to an inclined state away from the reaction unit 2, and its transfer device 41 deviates from the top of the cavity 25. The cavity 25 is located outside the U-shaped groove 482. The reaction unit 2 can move in the vertical direction and be disassembled or assembled from the mounting seat 6.

[0182] That is, when the pipetting unit 4 is in the first position, the entire detection instrument 100 can be used normally. When the reaction unit 2 needs to be removed, the rotating body 48 needs to be moved to the second position, the reaction unit 2 is removed, and a new reaction unit 2 is replaced. The rotation of the rotating body 48 drives the transfer device 41 away from the reaction unit 2, which is simple to operate.

[0183] The main unit 1 also includes two side panels, the bottom ends of which are fixedly connected to the bottom plate 11 and are respectively located on both sides of the rotating body 48. One of the side panels extends in the vertical direction and is located between the rotating body 48 and the first drive unit 5, and is located below the reaction unit 2. This side panel is defined as the first side panel 12, and the other side panel is an inclined panel that gradually deviates from the rotating body 48 from the lower end to the top end. This side panel is defined as the second side panel 13.

[0184] The third driving unit includes two mutually attracting magnetic members, which are defined as a first N magnetic block 491 and a first S magnetic block 492 . The first N magnetic block 491 and the first S magnetic block 492 are respectively embedded in the rotating body 48 and the first side plate 12 and are arranged opposite to each other.

[0185] In the first position, the first N magnetic block 491 and the first S magnetic block 492 attract each other and fit completely together, and the rotating body 48 abuts against the first side plate 12, which can prevent the rotating body 48 from shaking, making the pipetting unit 4 more stable in the first position. In addition, when the pipetting unit 4 is transferred from the second position to the first position, the first N magnetic block 491 and the first S magnetic block 492 attract each other, which can also play a positioning role, preventing the pipetting unit 4 from deviating from the preset position. The pin 42 of the pipetting unit 4 needs to be precisely matched with the top opening 26 of the cavity 25. The top opening 26 of the cavity 25 is relatively small. If the pipetting unit 4 deviates slightly from the preset position, the pin 42 may not be able to be inserted into the cavity 25. Therefore, the cooperation between the first N magnetic block 491 and the first S magnetic block 492 can ensure that when the pipetting unit 4 rotates from the second position to the first position, the rotating body is fully rotated to the preset position and accurately positioned.

[0186] The fourth driving unit also includes two mutually attracting magnetic parts, which are defined as a second N magnetic block 493 and a second S magnetic block 494. The second N magnetic block 493 and the second S magnetic block 494 are respectively embedded in the opposite side surfaces of the rotating body 48 and the second side plate 13, and are arranged opposite to each other.

[0187] When the pipetting unit 4 rotates from the first position to the second position, the second N magnetic block 493 and the second S magnetic block 494 attract each other, and the rotating body 48 and the second side plate 13 fit together, restricting the rotating body 48 from continuing to rotate and ensuring that the rotating body 48 is in a stable state.

[0188] The third driving unit is used to drive the rotating body 48 to rotate from the second position to the first position, and the fourth driving unit is used to drive the rotating body 48 to rotate from the first position to the second position.

[0189] In addition, as a preferred embodiment, a first roller 483 is also installed on the bottom wall of the transfer device 41, and a second roller 484 is also provided on the top wall of the rotating body 48. The first roller 483 and the second roller 484 can be rolled and located in the U-shaped groove 482, and in the first position, the first roller 483 and the second roller 484 are spaced apart from the reaction unit 2, the first roller 483 is located above the reaction unit 2, and the second roller 484 is located below the reaction unit 2, and the axis of the second roller 484, the axis of the first roller 483 and the axis of rotation of the rotating body 48 are parallel to each other.

[0190] When the reaction unit 2 needs to be disassembled, the pipetting unit 4 is in the first position and needs to be moved from the first position to the second position. When the reaction unit 2 is moved upward, its top end contacts the first roller 483. As the reaction unit 2 moves upward, the first roller 483 rotates counterclockwise, thereby pushing the rotating body 48 toward the second position. In other words, the reaction unit 2 and the pipetting unit 4 form an integral linkage, eliminating the need to manually drive the pipetting unit 4 to rotate.

[0191] Due to the provision of the fourth driving unit, the rotating body 48 only needs to deviate from the reaction unit 2 and rotate a certain angle to be quickly adsorbed onto the second side plate 13 .

[0192] When the reaction unit 2 is to be installed, the pipetting unit 4 is in the second position. As the reaction unit 2 is lowered onto the mounting base 6, the pipetting unit 4 is offset from above the reaction unit 2 in the second position. Therefore, the reaction unit 2 will not contact the first roller 483 during the installation process. However, after the reaction unit 2 is installed, if the reaction unit 2 is further pressed downward, the bottom end of the reaction unit 2 will push the second roller 484 to roll, thereby driving the rotating body 48 to rotate toward the first position.

[0193] In addition, due to the provision of the third driving unit, the rotating body 48 only needs to rotate a certain angle toward the reaction unit 2 to be quickly and accurately adsorbed onto the first side plate 12 .

[0194] The analysis unit 3 is preferably mounted on the support column 481. When the pipetting unit 4 is in the first position, the analysis unit 3 is aligned with the window of one of the cavities 25 and the side cover 27, and the analysis unit 3 can read and receive the reflected spectrum signal of the test paper 28. As the optical reaction unit rotates, the windows of the multiple cavities are aligned with the analysis unit one by one, and the optical reaction unit can read the reflected spectrum signal of the test paper in each cavity.

[0195] Of course, in a preferred embodiment, multiple test strips 28 can be installed on the mounting plate. The multiple test strips 28 can be aligned with the analysis unit as the reaction unit rotates, and the analysis unit can read the emission spectrum signals of the multiple test strips.

[0196] When the user is in use, the collection chamber receives the urine sample, and sends the sample to the cavity 25 through the pump, the transfer tube 46 and the pin 42 structure, and reacts with the test paper 28. The data processing unit then sends a detection instruction to the analysis unit 3. The analysis unit 3 is an optical detection. After receiving the detection instruction, the light source of the analysis unit 3 emits a test light of a preset wavelength toward the cavity 25. The test light enters the cavity 25 through the side panel and is reflected on the test paper 28 in the cavity 25. The reflected light is irradiated onto the spectral sensor. The wavelength selection in the spectral sensor first selects light of a set wavelength from the incident light, and then converts the light of the set wavelength into an electrical signal. The electrical signal is the detection data. After generating the detection data, the spectral sensor sends the detection data to the data processing unit. The data processing unit produces liquid analysis results based on the detection data for the user to view.

[0197] In an alternative embodiment, after detection, the test paper 28 can spontaneously emit detection light, and the analysis unit 3 only needs to receive this detection light to complete the detection. For example, ECL reagents work by oxidation-induced luminescence. Luminol, the main component of the luminescent substrate, is oxidized under alkaline conditions by horseradish peroxidase (HRP) to produce an excited-state intermediate of 3-aminophthalic acid. When the intermediate returns to the ground state, it emits photons with a maximum emission wavelength of 425 nm. This photon signal can be captured by X-ray film or an imager.

[0198] In a urine analysis, multiple tests need to be performed on the urine. At this time, multiple detection reagents can also be installed in the multiple cavities 25 of the reaction unit 2. The multiple detection reagents react with the sample in the cavity 25 respectively. The analysis unit 3 will perform multiple optical tests on the sample to obtain multiple detection data, so that the data processing unit can generate urine analysis results based on these multiple detection data for the user to view.

[0199] The optical detection module can perform optical detection on the mixed liquid after the reaction of urine and detection reagent in the cavity 25 based on the received detection instructions to obtain detection data. That is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis, so that the user can view the urine analysis data and understand his or her own physical health status.

[0200] In other embodiments, different analysis units may be selected according to the reaction type between the first substance and the second substance. The analysis unit is used to analyze the reactants of the reaction between the first substance and the second substance. For example, the analysis unit 3 may also use electrochemical or mass spectrometry detection.

[0201] In the detection instrument of the present invention, the reaction unit and the pipetting unit move relative to each other. The sample only needs to be sent to the cavity of the reaction unit and react with the test paper or a quantitative reagent. Since multiple cavities are provided, multiple tests can be performed without the need for cleaning equipment, and the detection accuracy can also be guaranteed.

[0202] The present invention also relates to a control method for a detection instrument, the control method comprising the steps of:

[0203] S1. so that the first substance is disposed at the reaction site;

[0204] S2. Controlling the relative movement of the pipetting unit and the reaction unit so that one of the reaction positions is in the operating position;

[0205] S3. transferring the second substance from the pipetting unit to the reaction site, and the first substance and the second substance react and form a reactant;

[0206] S4. Using the analysis unit to analyze the reactants of the reaction site, and sending the analysis data to the data processing unit;

[0207] S5. Process the analysis data using a data processing unit, and obtain a final detection result by analyzing the analysis data.

[0208] If the first substance is a test paper and the second substance is a sample, the analysis unit can detect a reactant formed by the reaction between the sample and the test paper.

[0209] Furthermore, the detection instrument further comprises the aforementioned main unit, a first drive unit, and a mounting base, wherein the first drive unit is connected to the main unit. The mounting base is connected to the output shaft of the first drive unit. The reaction unit is detachably connected to the mounting base. The reaction unit is rotatably connected to the main unit about a vertical axis; the plurality of reaction positions are arranged at intervals along the circumference of the reaction unit.

[0210] In step S2, the mounting base and the reaction unit can be driven to rotate around the vertical axis by the first driving unit, and one of the reaction positions is rotated to a preset position, which is aligned with the analysis unit.

[0211] In an example of using an insertion needle, in step S3 , a pump drives the second substance in the collection chamber into the insertion needle, and the insertion needle moves into the reaction site and transfers the second substance to the reaction site.

[0212] Furthermore, the transfer device is provided with a movable channel, with a first opening and a second opening at both ends thereof, and the first opening is aligned with the reaction position. The reaction position is a cavity and has a top opening. The transfer device is located above the reaction unit. The movable channel extends in a vertical direction, with the first opening located at the bottom end of the movable channel and the second opening located at the top end of the movable channel. The pin can be moved in the vertical direction and installed in the movable channel, and the pin head can be moved into or out of the reaction position from the top opening of the reaction position;

[0213] In step S3, after the pump drives the second substance in the collection chamber to the insertion needle, the insertion needle moves downward into the reaction position and transfers the second substance to the reaction position.

[0214] As a preferred solution, a second driving unit is further provided in the movable channel, and the second driving unit is connected to the pin.

[0215] In step S3, after the pump drives the second substance in the collection chamber to the insertion needle, the second driving unit drives the insertion needle downward into the reaction position and transfers the second substance to the reaction position.

[0216] Optionally, the pipetting unit further comprises a second elastic member, and the second elastic member is installed in the moving channel;

[0217] In step S3 , the second driving unit drives the pins to move downward into the reaction position and transfers the second substance to the reaction position, and then the second elastic member drives the pins to move upward out of the reaction position.

[0218] Optionally, the reaction unit is detachably connected to the main unit. The pipetting unit is rotatably connected to the main unit about a horizontal axis. The pipetting unit can rotate between a first position and a second position. In the first position, the pipetting unit can deliver the second substance to the reaction site. In the second position, the reaction unit can be removed from or installed on the mounting base. The first position is the working state of the detection instrument, and the second position is mainly for easy removal and installation of the reaction unit.

[0219] In steps S2 to S5, the pipetting unit is in the first position;

[0220] After repeating steps S1-S5 for a preset period, the method further includes:

[0221] Step S6: rotating the pipetting unit to the second position, so that the pipetting unit deviates from the reaction unit, and removing the reaction unit from the mounting base.

[0222] Step S7, replace the new reaction unit, rotate the pipetting unit from the second position to the first position, and start the detection after returning to the working state, and repeat steps S1-S5 again.

[0223] Optionally, the pipetting unit further comprises a rotating body, the bottom end of which is rotatably connected to the main body unit, and the top end of the rotating body is provided with a support column. The bottom end of the transfer device is connected to the top end of the support column, and the bottom wall of the transfer device, the side walls of the support column, and the top wall of the rotating body form a U-shaped groove. In the first position, the reaction position is located within the U-shaped groove. In the second position, the reaction position is located outside the U-shaped groove.

[0224] Step S6: rotating the pipetting unit to the second position, rotating the reaction unit to the outside of the U-shaped groove, and removing the reaction unit from the lower upper mounting seat;

[0225] In step S7, after replacing the new reaction unit, the pipetting unit is rotated to the first position, the reaction unit is located in the U-shaped groove, and then steps S1 to S5 can be started.

[0226] Preferably, the bottom wall of the transfer device is further provided with a first roller; the top wall of the rotating body is further provided with a second roller. The radial outer side of the reaction unit is located in the U-shaped groove;

[0227] In step S6, the reaction unit moves from the first position to the second position, pushing the first roller to roll, and driving the pipetting unit to rotate to the second position, so that the reaction unit is outside the U-shaped groove, and the reaction unit is disassembled;

[0228] In step S7, the installation of the new reaction unit to the mounting seat pushes the second roller to roll and drives the pipetting unit to rotate to the first position. At this time, the new reaction unit moves into the U-shaped groove, completing the installation of the new reaction unit.

[0229] Optionally, the pipetting unit further includes a third driving unit, the third driving unit being connected to the main unit and the rotating body, and being configured to drive the rotating body to rotate from the second position to the first position;

[0230] In step S6 , the reaction unit pushes the first roller to roll during the process of moving from the first position to the second position, and the third driving unit drives the reaction unit to rotate to the second position.

[0231] Optionally, the pipetting unit further includes a fourth driving unit, the fourth driving unit being connected to the main unit and the rotating body, and being configured to drive the rotating body to rotate from the first position to the second position;

[0232] In step S7 , when the new reaction unit is installed on the mounting seat, the second roller is pushed to roll, driving the pipetting unit to rotate, and the fourth driving unit drives the pipetting unit to rotate to the first position.

[0233] The fourth driving unit and the third driving unit are the aforementioned magnetic blocks that attract each other.

[0234] Optionally, the reaction unit includes a reagent disk and a sealing film, wherein the reagent disk is provided with a plurality of reaction sites, top openings of the plurality of reaction sites are located on the top surface of the reagent disk, and the sealing film is sealingly connected to the top surface of the reagent disk and seals the top openings of the reaction sites;

[0235] In step S3, the pump drives the second substance in the collection chamber to the insertion needle, and the insertion needle pierces the sealing film downward and moves into the reaction site from the top opening of the reaction site, and then transfers the second substance to the reaction site.

[0236] Furthermore, the reaction position is provided with a window open toward the radial outer side of the reagent disc, and a side cover is installed outside the window, and the side cover is made of a light-transmitting material. The analysis unit is connected to the support column and can rotate with the rotating body.

[0237] In step S2, the first driving unit drives the mounting base and the reaction unit to rotate around the vertical axis, and aligns one of the reaction sites with the analysis unit;

[0238] Repeat steps S1-S5 for a preset period, the first driving unit drives the mounting base and the reaction unit to rotate around the vertical axis, and the multiple reaction positions are aligned with the analysis unit one by one.

[0239] While preferred embodiments of the present invention have been described in detail above, it should be understood that aspects of the embodiments can be modified, if necessary, to employ aspects, features and concepts of the various patents, applications and publications to provide further embodiments.

[0240] These and other changes can be made to the embodiments in light of the above detailed description.In general, in the claims, the terms used should not be construed as limited to the specific embodiments disclosed in the specification and claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which these claims are entitled.

[0241] Those skilled in the art will appreciate that the above-mentioned embodiments are specific examples for implementing the present invention, and that in actual applications, various changes may be made thereto in form and detail without departing from the spirit and scope of the present invention.

Claims

1. A detection instrument, characterized in that: The detection instrument comprises: A reaction unit, wherein the reaction unit is provided with a plurality of reaction positions for containing the first substance; The pipetting unit is configured to be movable relative to the reaction unit to transport the second substance into the plurality of reaction sites.

2. The detection instrument according to claim 1, characterized in that: The pipetting unit is configured to be capable of relative translational movement with the reaction unit.

3. The detection instrument according to claim 1, characterized in that: The pipetting unit is configured to be rotatable relative to the reaction unit.

4. The detection instrument according to claim 1, characterized in that The pipetting unit is configured to be capable of swinging relative to the reaction unit.

5. The detection instrument according to claim 1, characterized in that: The pipetting unit is configured to perform one or more combined movements of translation, rotation or swing relative to the reaction unit.

6. The detection instrument according to claim 3, characterized in that: The detection instrument also includes a main body unit; The reaction unit and the main body unit are rotatably connected around a vertical axis; The plurality of reaction sites are arranged at intervals along the circumference of the reaction unit.

7. The detection instrument according to claim 6, characterized in that: The detection instrument also includes a mounting base and a first driving unit; The first driving unit is connected to the main body unit; The mounting seat is connected to the output shaft of the first driving unit; The reaction unit is detachably connected to the mounting seat.

8. The detection instrument according to claim 7, characterized in that: The detection instrument also includes a quick-release part, which is connected to the mounting base and can be switched between a first state, a second state and a third state. In the first state, the quick-release part restricts the reaction unit from being separated from the mounting base; in the second state, the reaction unit can be removed from the mounting base or installed on the mounting base; in the third state, the reaction unit is separated from the mounting base.

9. The detection instrument according to claim 8, characterized in that: The side of the mounting seat is provided with a mounting groove; The detection instrument also includes: a limiting member connected to an inner wall of the mounting groove and rotatable between a first state, a second state, and a third state, wherein in the first state, an outer end of the limiting member is located outside the mounting seat and abuts against the reaction unit; and in the second state and the third state, the outer end of the limiting member is located within the mounting groove; A first restoring member is connected to the limiting member or the mounting seat and is used to drive the outer end of the limiting member to rotate toward the outside of the mounting groove.

10. The detection instrument according to claim 9, characterized in that: A rotating shaft is installed in the installation groove; The inner end of the limiting member is rotatably connected to the rotating shaft; The first restoring member is an elastic member installed on the rotating shaft, one end of the elastic member is fixedly connected to the limiting member, and the other end abuts against the inner wall of the installation groove.

11. The detection instrument according to claim 10, characterized in that: The limiting member includes a pressing surface and a limiting surface that are adjacently arranged, and the corners of the pressing surface and the limiting surface are the outer ends of the limiting member; In the first state, the distance between the limiting surface and the mounting seat gradually increases from the bottom end to the top end, and the pressing surface is a horizontal surface.

12. The detection instrument according to claim 11, characterized in that: The mounting groove opens toward the top surface of the mounting seat; The limiting member includes a pressing portion, the pressing portion is movably connected to the mounting seat along a vertical direction, and the bottom end of the pressing portion abuts against the pressing surface.

13. The detection instrument according to claim 11, characterized in that: The pressing portion is elastically connected to the mounting seat.

14. The detection instrument according to claim 11, characterized in that: The mounting seat is provided with a supporting surface, and a first elastic member is provided on the top surface of the supporting surface; The reaction unit is located on the top surface of the first elastic member; In the first state, the bottom surface of the reaction unit presses the first elastic member.

15. The detection instrument according to claim 14, characterized in that: The radial inner side of the reaction unit is cylindrical, and at least two areas of the radial inner side of the reaction unit have different distances from the center; The radially outer shape of the mounting seat complements the radially inner shape of the reaction unit.

16. The detection instrument according to claim 6, characterized in that: The pipetting unit comprises: transfer device; and An insertion needle is movably connected to the transfer device and has a head end and a tail end, the head end is provided with a needle tip and can be moved into or out of the reaction position, and the tail end is connected to the collection chamber containing the second substance.

17. The detection instrument according to claim 16, characterized in that: The transfer device is provided with a moving channel, the two ends of the moving channel are respectively a first opening and a second opening, and the first opening is aligned with the reaction position; The insertion pin is movably installed in the movable channel, with the head end of the insertion pin located at the first opening and the tail end located at the second opening.

18. The detection instrument according to claim 17, characterized in that: The reaction site is a cavity with a top opening; The transfer device is located above the reaction unit; The movable channel extends in a vertical direction, the first opening is located at the bottom end of the movable channel, and the second opening is located at the top end of the movable channel; The insertion pin is installed in the movable channel in a vertically movable manner, and the head end of the insertion pin can be moved into or out of the reaction position from the top opening of the reaction position.

19. The detection instrument according to claim 18, characterized in that: A second driving unit is further provided in the movable channel. The second driving unit is connected to the insertion pin and can operably drive the insertion pin to move in a vertical direction.

20. The detection instrument according to claim 19, characterized in that: The second driving unit includes: a magnet connected to the pin; A coil is connected to the moving channel.

21. The detection instrument according to claim 20, characterized in that: The moving unit further includes a moving block, and the moving block is located in the moving channel; The pin and the magnet are both connected to the moving block.

22. The detection instrument according to claim 21, characterized in that: The second opening is located at the top side of the transfer device; The moving block is provided with an L-shaped transfer cavity, one end of which is open toward the bottom end of the moving block and is used to install the tail end of the pin; The other end of the adapter cavity is opened toward the side of the moving block and is aligned with the second opening, for installing the adapter tube; The adapter tube is connected to the tail end of the pin to communicate with the collection cavity; The magnet is connected to the top end of the moving block; The coil is connected to the top wall of the moving channel.

23. The detection instrument according to claim 22, characterized in that: The detection instrument further comprises a pump or a piezoelectric micropump, which is connected to the transfer tube and is used to drive the second substance into the reaction site.

24. The detection instrument according to claim 22, characterized in that: The pipetting unit further includes a second elastic member installed in the moving channel and operable to drive the insertion pin to move upward.

25. The detection instrument according to claim 24, characterized in that: The moving channel includes a first section, a second section and a third section which are arranged in sequence from the top end to the bottom end and are connected to each other; The first section is provided with the second opening; The third section has the first opening; The width of the first segment is greater than the width of the second segment, and the width of the second segment is greater than the width of the third segment; The movable block is movably mounted in the first section, and the coil is mounted on the top wall of the first section; The top end of the second elastic member is located in the first section and connected to the moving block, and the bottom end is located in the second section and connected to the bottom wall of the bottom end.

26. The detection instrument according to claim 16, characterized in that: The reaction unit is detachably connected to the main body unit; The pipetting unit is rotatably connected to the main body unit around a horizontal axis. The pipetting unit can rotate between a first position and a second position. In the first position, the pipetting unit can transport the second substance into the reaction site; in the second position, the reaction unit can be removed from or installed on the main body unit.

27. The detection instrument according to claim 26, characterized in that: The reaction unit and the main body unit can be detachably connected in the vertical direction; The pin is connected to the transfer device so as to be movable along the vertical direction; In the first position, the transfer device is located above the reaction position; In the second position, the transfer device is offset from above the reaction position.

28. The detection instrument according to claim 27, characterized in that: The pipetting unit further comprises a rotating body, the bottom end of the rotating body is rotatably connected to the main body unit, and the top end of the rotating body is provided with a support column; The bottom end of the transfer device is connected to the top end of the support column, and the bottom wall of the transfer device, the side wall of the support column and the top wall of the rotating body form a U-shaped groove; In the first position, the reaction site is located in the U-shaped groove; In the second position, the reaction site is located outside the U-shaped groove.

29. The detection instrument according to claim 28, characterized in that The bottom wall of the transfer device is further provided with a first roller; The top wall of the rotating body is further provided with a second roller; The radial outer side of the reaction unit is located in the U-shaped groove.

30. The detection instrument according to claim 28, characterized in that The pipetting unit further includes a third driving unit connected to the main body unit and the rotating body, and configured to drive the rotating body to rotate from the second position to the first position.

31. The detection instrument according to claim 30, characterized in that The third driving unit is two magnetic members attracted to each other.

32. The detection instrument according to claim 30, characterized in that The pipetting unit further includes a fourth driving unit connected to the main body unit and the rotating body, and configured to drive the rotating body to rotate from the first position to the second position.

33. The detection instrument according to claim 32, characterized in that The main unit includes: a bottom plate, the rotating body being rotatably connected to the bottom plate; and Two side plates, the two side plates are respectively located on both sides of the rotating body; The third driving unit is connected to one of the side plates, and the fourth driving unit is connected to the other side plate.

34. The detection instrument according to claim 28, characterized in that The reaction unit comprises: A reagent tray, wherein the reagent tray is provided with a plurality of the reaction sites, and the top openings of the plurality of the reaction sites are located on the top surface of the reagent tray; and a sealing film, the sealing film being sealingly connected to the top surface of the reagent disk and sealing the top opening of the reaction site; The head end of the insertion needle can pierce the sealing membrane and move into or out of the reaction site through the top opening of the reaction site.

35. The detection instrument according to claim 34, characterized in that The reaction position is provided with a window open toward the radial outer side of the reagent disk; The reaction unit further includes a side cover, which is made of a light-transmitting material and covers the window; The detection instrument further comprises an analysis unit; The windows of a plurality of the reaction sites are operably aligned with the analysis unit.

36. The detection instrument according to claim 35, characterized in that The analysis unit is connected to the support column; The first substance is a plurality of test papers; In the first position, a plurality of the test strips are operably aligned with the analyzing unit.

37. The detection instrument according to claim 36, characterized in that A mounting plate is provided in the reaction position, and a groove for the test paper is provided on the outer side of the mounting plate; the top of the mounting plate is aligned with the top opening of the reaction position and is provided with a guide structure, and the guide structure is connected to the groove.

38. The detection instrument according to claim 35, characterized in that The detection instrument further includes a data processing unit, which is connected to the analysis unit and is used to receive and analyze data from the analysis unit.

Images