Processing method suitable for feeding raw materials of wine-processed rhizoma polygonati formula granules

Abstract

The invention discloses a processing method suitable for feeding raw materials of wine-processed rhizoma polygonati formula granules. The processing method comprises the following steps: cleaning and leaching rhizoma polygonati raw medicinal materials, slightly draining off the rhizoma polygonati raw medicinal materials, and steaming the rhizoma polygonati raw medicinal materials in a steam box for 1 hour; after the rhizoma polygonati is cooled, the rhizoma polygonati is cut, and the thickness of slices is controlled to be 2-4 mm; drying the cut thick rhizoma polygonati slices at a low temperature of 50-60 DEG C; according to the mass ratio of the rhizoma polygonati to the yellow rice wine being 100: 20, the dried rhizoma polygonati thick slices and the yellow rice wine are evenly stirred and moistened, and the moistened time is 2-4 h; putting the thoroughly moistened rhizoma polygonati thick slices into a steam box to be steamed for 6-10 hours, and collecting steaming liquid; uniformly stirring the thick rhizoma polygonati slices and the steaming liquid, and absorbing completely; and drying the rhizoma polygonati thick slices mixed with the distilled liquid at a low temperature of 50-60 DEG C, and detecting that the water content of the rhizoma polygonati thick slices is lower than 13% by a rapid detector, so as to obtain a clean medicinal material for feeding the wine rhizoma polygonati formula granules. By controlling the technological parameters such as steaming times, steaming time, drying temperature and the like, the pure medicinal material which can be used for feeding the wine-processed rhizoma polygonati (polygonatum cyrtonema) formula granules is processed.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparation, and in particular to a preparation method suitable for raw materials of wine-scented polygonatum formula granules. Background Art

[0002] Huangjing (Polygonatum cyrtonema Hua) is a processed product of the dried rhizome of Polygonatum cyrtonema Hua, a plant of the Liliaceae family, which has been processed through wine. It has the effects of replenishing qi and nourishing yin, strengthening the spleen and moistening the lungs, nourishing the kidneys and benefiting essence, and enhancing immunity. Traditional wine-processed Huangjing relies on the experience of "nine steaming and nine drying", supplemented by stewing or steaming with rice wine to achieve the quality standard of "black as lacquer and sweet as honey". However, traditional processing methods have obvious limitations and are difficult to meet the standardization requirements of modern Chinese medicine production. First, traditional processes rely on empirical operations, and there is a lack of unified standards for the number of steaming times, time, temperature, and amount of rice wine used, resulting in large fluctuations in the quality of processed products. For example, the "nine steaming and nine drying" process takes up to several weeks, with low production efficiency, and the color, smell, and taste of different batches vary significantly, affecting the stability of clinical efficacy. Secondly, the mechanism of component changes during the processing process is unclear. In particular, the degradation and transformation between Polygonatum sibiricum polysaccharide, the content index component specified in the medicinal materials and decoction pieces, and fructose, the index component specified in the formula granules, has not been systematically studied. As a result, the judgment of the processing endpoint of Polygonatum sibiricum (Polygonatum multiflorum) formula granules as a raw material is still mainly based on empirical observation and lacks objective indicators. In addition, the traditional processing process is energy-intensive and has a long cycle, making it difficult to adapt to the needs of industrial continuous production, which restricts the large-scale application of Polygonatum sibiricum in the field of traditional Chinese medicine formula granules.

[0003] As a modern alternative to traditional decoctions, Chinese herbal formula granules place higher demands on the preparation of raw materials. According to the Technical Requirements for Quality Control and Standardization of Chinese Herbal Formula Granules, the raw materials of formula granules must maintain the same material basis as the standard decoction, so the preparation process must be repeatable, efficient, and controllable. Specifically, the preparation of Huangjing (Shenghuangjing) must meet the following conditions: (1) process parameters (such as the number of steaming times, steaming time, and drying temperature) must be quantified to ensure batch-to-batch quality stability; (2) the dynamic changes of key components (such as fructose and polysaccharides) must be clarified, and quality control indicators related to efficacy must be established; (3) the production process must be optimized, the cycle must be shortened, and the feasibility of industrialization must be improved. Summary of the Invention

[0004] The present invention aims to address the current processing issues of Polygonatum odoratum (Polygonatum multiflorum) in the industry and to provide a method for preparing Polygonatum odoratum (Polygonatum multiflorum) formula granules. By optimizing the number of steaming steps, steaming time, and drying temperature, the present invention significantly increases the fructose content while retaining active polysaccharides, ensuring the efficacy and taste of the processed product.

[0005] A method for preparing raw materials for wine-scented polygonatum granules, comprising the following steps:

[0006] Step (1): clean and rinse the raw material of Polygonatum sibiricum, drain it slightly and then steam it in a steamer;

[0007] Step (2): After the polygonatum is cooled, cut it into thick slices;

[0008] Step (3): low-temperature drying the cut thick slices of Polygonatum sibiricum;

[0009] Step (4): Mix the dried thick slices of polygonatum and yellow rice wine in a mass ratio of 100:20 and let them soak;

[0010] Step (5): placing the soaked thick slices of Polygonatum sibiricum into a steamer for steaming, and collecting the steamed liquid;

[0011] Step (6): Mix the thick slices of Polygonatum sibiricum with the steamed liquid and absorb them thoroughly;

[0012] Step (7): Dry the thick slices of polygonatum mixed with the steamed liquid at low temperature to obtain the clean medicinal materials used for the wine polygonatum formula granules.

[0013] Preferably, in step (1), the steaming time is 1 hour and the temperature is 100°C.

[0014] Preferably, in step (2), the slice thickness is approximately 2 to 4 mm.

[0015] Preferably, in step (3) and step (7), the low-temperature drying temperature is 50-60° C., and the drying is stopped when the moisture content of the thick slices of Polygonatum sibiricum is lower than 13%.

[0016] Preferably, in step (4), the soaking time is 2 to 4 hours.

[0017] Preferably, in step (5), the steaming time is 6-10 hours and the temperature is 100°C.

[0018] The beneficial effects produced by the present invention are:

[0019] 1. Improve the scientificity and controllability of the preparation process: Through systematic research on the transformation rules of fructose, clarify the dynamic relationship between polysaccharide degradation and fructose accumulation, establish the "fructose / polysaccharide ratio" as a key quality control indicator, and shift the preparation process from empirical judgment to data-driven, greatly improving batch consistency and ensuring the quality stability of the raw materials for formula granules.

[0020] 2. Optimize production efficiency and reduce production costs: The traditional "nine steaming and nine drying" process has a long cycle and high energy consumption. This study optimizes the number of steaming times (such as reducing it to 2 times), steaming time (6-10 hours) and drying temperature of 50-60°C. While ensuring efficacy, it significantly shortens the production cycle and reduces energy consumption, making it more suitable for industrial continuous production needs.

[0021] 3. The fructose / polygonatum polysaccharide ratio in the processed pure medicinal material is within the range of 7.9 to 12.5, which not only meets the requirements for the content of polygonatum polysaccharide in wine-scented polygonatum slices stipulated in the 2020 edition of the Chinese Pharmacopoeia, but can also be used as a raw material for wine-scented polygonatum (polygonatum multiflorum) formula granules. The quality of the finished granules produced fully meets the various technical indicators for wine-scented polygonatum (polygonatum multiflorum) formula granules in the formula granule standards of Hubei and other provinces: the fructose content is stably controlled within the range of 200.0 to 380.0 mg / g, and the paste yield is maintained between 42% and 58%. This production process is stable and reliable, and the product quality is excellently controllable. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a morphology diagram of the prepared decoction pieces in Comparative Example 1;

[0023] Figure 2 This is a schematic diagram of the test results of the content of polygonatum polysaccharide and fructose in the wine-cured polygonatum medicinal material at different steaming times in the experimental example. DETAILED DESCRIPTION

[0024] The present invention is explained in detail below with reference to examples, but the following examples do not limit the present invention in any way.

[0025] In the following examples, the content of polygonatum polysaccharide contained in the original medicinal material of polygonatum (polygonatum multiflorum) and the pure medicinal material of wine polygonatum (polygonatum multiflorum) was detected according to the detection requirements of the [Content Determination] under the item of polygonatum in the 2020 edition of the "Chinese Pharmacopoeia"; the content of fructose was detected with reference to the detection method under the [Content Determination] item of Hubei Province Wine Polygonatum (polygonatum multiflorum) formula granules.

[0026] Example 1

[0027] This embodiment provides a method for preparing raw materials for the formula granules of Polygonatum odoratum (Polygonatum multiflorum), comprising the following steps:

[0028] Step (1): clean and rinse the raw material of Polygonatum sibiricum (Polygonatum multiflorum), drain it slightly, and then steam it in a steamer at 100° C. for 1 hour;

[0029] Step (2): After the polygonatum (polygonatum multiflorum) has cooled, it is cut into slices with a thickness of 3 mm;

[0030] Step (3): Drying the sliced Polygonatum sibiricum (Polygonatum multiflorum) at 55° C. until the moisture content is lower than 13% as detected by a rapid detector;

[0031] Step (4): Mix the dried thick slices of polygonatum (polygonatum multiflorum) and yellow rice wine in a ratio of 100:20 by mass, and let them soak for 2 hours;

[0032] Step (5): placing the soaked thick slices of Polygonatum sibiricum (Polygonatum multiflorum) into a steamer at 100° C. for 6 h, and collecting the steamed liquid;

[0033] Step (6): Mix the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) with the steamed liquid and absorb it completely;

[0034] Step (7): Dry the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) mixed with the steamed liquid at 55°C, and wait until the moisture content is less than 13% as detected by a rapid detector, and the clean medicinal materials used for the preparation of the Polygonatum sibiricum (Polygonatum multiflorum) formula granules can be obtained.

[0035] The purified medicinal materials of Polygonatum odoratum (Polygonatum multiflorum) obtained in step (7) were used as raw materials for the preparation of the formula granules, and the preparation was carried out according to the Hubei Province Polygonatum odoratum (Polygonatum multiflorum) formula granules. The results are shown in Table 1.

[0036] Table 1

[0037] project Clean medicinal materials as raw materials Fructose content% 39.81％ Polygonatum polysaccharide content% 5.04％ Fructose / Polygonatum polysaccharide content ratio 7.90 Formula granule paste yield% 49.86％ Formula granules fructose content mg / g 325.3mg / g

[0038] The experimental results show that the pure medicinal materials obtained in step (7) of this embodiment are used as the raw materials for the preparation of the formula granules of Polygonatum odoratum (Polygonatum multiflorum), which is better than the raw materials directly used as the raw materials in step (1). The formula granules produced not only have a qualified paste yield but also a higher content, and meet the requirements of the formula granules of Polygonatum odoratum (Polygonatum multiflorum) in many provinces such as Hubei Province.

[0039] Example 2

[0040] This embodiment provides a method for preparing raw materials for the formula granules of Polygonatum odoratum (Polygonatum multiflorum), comprising the following steps:

[0041] Step (1): clean and rinse the raw material of Polygonatum sibiricum (Polygonatum multiflorum), drain it slightly, and then steam it in a steamer at 100° C. for 1 hour;

[0042] Step (2): After the polygonatum (polygonatum multiflorum) has cooled, it is cut into slices with a thickness of 3 mm;

[0043] Step (3): Drying the sliced Polygonatum sibiricum (Polygonatum multiflorum) at 57° C.; stopping the drying process when the moisture content is lower than 13% as detected by a rapid detector;

[0044] Step (4): Mix the dried thick slices of polygonatum (polygonatum multiflorum) and yellow rice wine in a ratio of 100:20 by mass, and let them soak for 3 hours;

[0045] Step (5): placing the soaked thick slices of Polygonatum sibiricum (Polygonatum multiflorum) into a steamer at 100° C. for 8 h, and collecting the steamed liquid;

[0046] Step (6): Mix the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) with the steamed liquid and absorb it completely;

[0047] Step (7): Dry the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) mixed with the steamed liquid at 57°C, and wait until the moisture content is less than 13% as detected by a rapid detector, and the clean medicinal materials used for the preparation of the wine-brewed Polygonatum sibiricum (Polygonatum multiflorum) formula granules can be obtained.

[0048] The purified medicinal material of Polygonatum odoratum (Polygonatum multiflorum) obtained in step (7) was used as the raw material for the formula granules thereof, and the production was carried out according to the Hubei Province Polygonatum odoratum (Polygonatum multiflorum) formula granule production method. The results are shown in Table 2.

[0049] Table 2

[0050] project Clean medicinal materials as raw materials Fructose content% 46.01％ Polygonatum polysaccharide content% 4.28％ Fructose / Polygonatum polysaccharide content ratio 10.75 Formula granule paste yield% 52.83％ Formula granules fructose content mg / g 369.2mg / g

[0051] The experimental results show that the clean medicinal materials obtained in step (7) of this embodiment are used as the raw materials for the preparation of wine-scented Polygonatum (polygonatum sibiricum) formula granules. The produced formula granules not only have a qualified paste yield but also a high content, which meets the requirements of wine-scented Polygonatum (polygonatum sibiricum) formula granules in many provinces such as Hubei Province.

[0052] Example 3

[0053] This embodiment provides a method for preparing raw materials for the formula granules of Polygonatum odoratum (Polygonatum multiflorum), comprising the following steps:

[0054] Step (1): clean and rinse the raw material of Polygonatum sibiricum (Polygonatum multiflorum), drain it slightly, and then steam it in a steamer at 100° C. for 1 hour;

[0055] Step (2): After the polygonatum (polygonatum multiflorum) has cooled, it is cut into slices with a thickness of 3 mm;

[0056] Step (3): Drying the sliced Polygonatum sibiricum (Polygonatum multiflorum) at 60° C.; stopping the drying process when the moisture content is lower than 13% as detected by a rapid detector;

[0057] Step (4): Mix the dried thick slices of polygonatum (polygonatum multiflorum) and yellow rice wine in a ratio of 100:20 by mass, and let them soak for 3 hours;

[0058] Step (5): placing the soaked thick slices of Polygonatum sibiricum (Polygonatum multiflorum) into a steamer at 100° C. for 10 h, and collecting the steamed liquid;

[0059] Step (6): Mix the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) with the steamed liquid and absorb it completely;

[0060] Step (7): Dry the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) mixed with the steamed liquid at 60°C, and wait until the moisture content is less than 13% as detected by a rapid detector, and the clean medicinal materials used for the preparation of the Polygonatum sibiricum (Polygonatum multiflorum) formula granules can be obtained.

[0061] The purified medicinal material of Polygonatum odoratum (Polygonatum multiflorum) obtained in step (7) was used as the raw material for the formula granules thereof, and the production was carried out according to the Hubei Province Polygonatum odoratum (Polygonatum multiflorum) formula granule preparation method. The results are shown in Table 3.

[0062] Table 3

[0063] project Clean medicinal materials as raw materials Fructose content% 50.86％ Polygonatum polysaccharide content% 4.07％ Fructose / Polygonatum polysaccharide content ratio 12.50 Formula granule paste yield% 55.84％ Formula granules fructose content mg / g 378.7mg / g

[0064] The experimental results show that the clean medicinal materials obtained in step (7) of this embodiment are used as the raw materials for the preparation of wine-scented Polygonatum (polygonatum sibiricum) formula granules. The produced formula granules not only have a qualified paste yield but also a high content, which meets the requirements of wine-scented Polygonatum (polygonatum sibiricum) formula granules in many provinces such as Hubei Province.

[0065] Comparative Example 1

[0066] This comparative example is the same as Example 3 except that in step (5), the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) after being thoroughly moistened are placed in a steamer and steamed for 4 hours.

[0067] The purified medicinal material of Polygonatum odoratum (Polygonatum multiflorum) obtained in step (7) was used as the raw material for the formula granules thereof, and the production was carried out according to the Hubei Province Polygonatum odoratum (Polygonatum multiflorum) formula granule production method. The results are shown in Table 4.

[0068] Table 4

[0069] project Clean medicinal materials as raw materials Fructose content% 27.08％ Polygonatum polysaccharide content% 6.28％ Fructose / Polygonatum polysaccharide content ratio 4.31 Formula granule paste yield% 39.27％ Formula granules fructose content mg / g 198.8mg / g

[0070] The experimental results show that the fructose / polysaccharide ratio of the purified medicinal material obtained in step (7) of this embodiment as the raw material for the preparation of Polygonatum odoratum (Polygonatum multiflorum) is 4.31, and the surface color of the prepared medicinal pieces is mostly brownish yellow. Figure 1As shown, it does not meet the requirements of the 2020 edition of the "Chinese Pharmacopoeia" under the [Properties] "The surface is brown to black, shiny, brown to light brown in the center, and small spots of veins are visible", and the content and yield of the formula granules produced by it as the raw material for wine-flavored polygonatum (polygonatum sibiricum) formula granules do not meet the requirements of the provincial standards for wine-flavored polygonatum (polygonatum sibiricum) formula granules, which are fructose content of 200.0-380.0 mg / g and paste yield of 42%-58%.

[0071] Comparative Example 2

[0072] This comparative example is the same as Example 3 except that in step (5), the thick slices of Polygonatum sibiricum (Polygonatum multiflorum) after being thoroughly moistened are placed in a steamer and steamed for 12 hours.

[0073] The purified medicinal material of Polygonatum odoratum obtained in step (7) was used as the raw material for the formula granules thereof, and the production was carried out according to the Hubei Province Polygonatum odoratum (Polygonatum odoratum) formula granule preparation method. The results are shown in Table 5.

[0074] Table 5

[0075] project Clean medicinal materials as raw materials Fructose content% 52.47％ Polygonatum polysaccharide content% 3.91％ Fructose / Polygonatum polysaccharide content ratio 13.42 Formula granule paste yield% 59.03％ Formula granules fructose content mg / g 400.2mg / g

[0076] The experimental results show that the fructose / polysaccharide ratio of the purified medicinal material obtained in step (7) of this embodiment as the raw material for the fermented Polygonatum odoratum (polygonatum multiflorum) is 13.42, and the polysaccharide content is 3.91%, which does not meet the requirements of the "Content" of the "Polygonatum odoratum" in the 2020 edition of the Chinese Pharmacopoeia. 12 O6), shall not be less than 4.0%". Moreover, the fructose content and the paste yield of the formula granules produced by using it as the raw material for wine-scented polygonatum (polygonatum sibiricum) formula granules do not meet the provincial standards for wine-scented polygonatum (polygonatum sibiricum) formula granules, which require a fructose content of 200.0-380.0 mg / g and a paste yield of 42%-58%.

[0077] Test example

[0078] This test case investigates the changes in the content of Polygonatum odoratum polysaccharide and fructose in the pure medicinal materials of Polygonatum odoratum obtained by steaming for different times. The results are as follows: Figure 2 shown.

[0079] like Figure 2It is shown that 1. After the raw medicinal materials of wine-soaked Polygonatum (polygonatum sibiricum) were cleaned and rinsed, and steamed for 1 hour, the contents of polygonatum polysaccharide and fructose contained in them increased; 2. With the extension of the steaming time after cutting, the content of polygonatum polysaccharide continued to decrease, and the decreasing trend was relatively gentle, while the fructose content increased sharply within the first 10 hours and reached a plateau. As the steaming time was further extended, the fructose content decreased slightly; 3. The fructose / polygonatum polysaccharide content ratio in the clean medicinal materials used as raw materials for wine-soaked Polygonatum (polygonatum sibiricum) formula granules was controlled within the range of 7.9-12.5, which not only ensured that the content of polygonatum polysaccharide in the clean medicinal materials met the requirements of the wine-soaked Polygonatum decoction pieces in the 2020 edition of the "Chinese Pharmacopoeia", but also ensured that the content and paste yield of the wine-soaked Polygonatum (polygonatum sibiricum) formula granules produced met the provincial standards for formula granules in each province. 4. During the second steaming of the raw material of Polygonatum odoratum (Polygonatum multiflorum), the color of the cleaned medicinal material gradually deepened from yellow to brownish yellow, then gradually turned to tan, and finally to black. After steaming for another 6 hours, the cleaned medicinal material was tan-brown with a slight sheen, with a brown to light brown center and small veins visible. The texture was relatively soft, and the taste was sweet with a slight wine aroma. This met the properties requirements of Polygonatum odoratum in the Pharmacopoeia.

[0080] The above embodiments are merely examples of preferred embodiments of the present invention and do not include all possible implementations of the invention. Any modifications and improvements made by those skilled in the art without departing from the spirit and scope of the present invention are deemed to fall within the scope of protection of the claims of the present invention.

Claims

1. A method for preparing raw materials for Huangjing formula granules, characterized in that: The steps include: Step (1): clean and rinse the raw material of Polygonatum sibiricum, drain it slightly and then steam it in a steamer; Step (2): After the polygonatum is cooled, cut it into thick slices; Step (3): low-temperature drying the cut thick slices of Polygonatum sibiricum; Step (4): Mix the dried thick slices of polygonatum and yellow rice wine in a mass ratio of 100:20 and let them soak; Step (5): placing the soaked thick slices of Polygonatum sibiricum into a steamer for steaming, and collecting the steamed liquid; Step (6): Mix the thick slices of Polygonatum sibiricum with the steamed liquid and absorb them thoroughly; Step (7): Dry the thick slices of polygonatum mixed with the steamed liquid at low temperature to obtain the clean medicinal materials used for the wine polygonatum formula granules.

2. The preparation method according to claim 1, characterized in that: In the step (1), the steaming time is 1 hour and the temperature is 100°C.

3. The processing method according to claim 1, characterized in that: In the step (2), the slice thickness is approximately 2 to 4 mm.

4. The processing method according to claim 1, characterized in that: In the steps (3) and (7), the low-temperature drying temperature is 50-60° C.; when the moisture content of the thick slices of Polygonatum sibiricum is lower than 13%, the drying is stopped.

5. The processing method according to claim 1, characterized in that: In the step (4), the soaking time is 2 to 4 hours.

6. The processing method according to claim 1, characterized in that: In the step (5), the steaming time is 6 to 10 hours and the temperature is 100°C.

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