Vacuum plasma treatment device and treatment method for leukocyte-depleted filter body

Abstract

The invention relates to a vacuum plasma treatment device and method for a leukocyte-depleting filter body, and belongs to the technical field of vacuum treatment of leukocyte-depleting filters. Comprising a placing frame assembly, a conveying belt and plasma treatment equipment. The placing frame assembly is placed on the conveying belt, and a connecting port of the liquid inlet end or the liquid outlet end of the leukocyte-depleted filter is vertically arranged upwards. The two ends, in the width direction, of the conveying belt are each provided with a horizontally-arranged bottom linear module, stand columns are fixed to sliding parts of the two bottom linear modules, a top linear module is jointly erected on the tops of the two stand columns, and a sliding part of the top linear module is fixedly connected with a plasma spray head of plasma treatment equipment. And the plasma nozzle is vertically arranged downwards. The liquid inlet port and the liquid outlet port of the leukocyte-depleted filter are modified through the vacuum plasma technology, the bonding strength of the leukocyte-depleted filter and the adhesive interface of the polyvinyl chloride pipeline is remarkably improved, and the hidden danger of interface separation in the moist heat sterilization process is effectively solved.

Description

Technical Field

[0001] The present application belongs to the technical field of vacuum treatment of leukocyte depletion filters, and specifically relates to a vacuum plasma treatment device and treatment method for a leukocyte depletion filter body. Background Art

[0002] In the field of blood component separation technology, leukocyte removal filters are one of the key devices for achieving clinical transfusion safety. Through physical interception or adsorption mechanisms, these filters can effectively remove white blood cells from whole blood or blood components, reducing the risk of transfusion-related immune reactions. Currently, the core filter material of leukocyte removal filters is mostly polypropylene (PP), which has advantages including high chemical stability and good biocompatibility. It can also be formed into a uniform microporous structure through precision injection molding, meeting the precision requirements for white blood cell retention.

[0003] The inlet and outlet ends of the filter need to be connected to external pipes to construct a closed blood transmission channel. Due to cost and processing convenience considerations, polyvinyl chloride (PVC) is usually used for such pipes. PVC has the characteristics of high flexibility and strong pressure resistance, and can adapt to the needs of repeated bending and pressure changes in clinical operations. However, PP and PVC belong to different categories of thermoplastic polymer materials, and the molecular polarity of the two is significantly different, which makes direct melt welding more difficult. Therefore, the existing technology mostly uses adhesives to achieve the interface bonding between the two.

[0004] In the medical device production process, moist heat sterilization is a necessary step to ensure product sterility, and it usually needs to be maintained at 120°C in a saturated steam environment for 20-30 minutes. However, the thermal expansion coefficients of PP and PVC differ significantly, and stress concentration is prone to occur at the interface under moist heat conditions. In addition, the adhesive itself has insufficient moisture and heat resistance, and long-term high temperature and high humidity environments can cause its molecular chains to break or the interface to debond. In actual production, it was found that approximately 15%-20% of filter-pipe connectors experienced sealing failure after sterilization, manifested as leakage or complete separation at the interface, which may cause blood contamination or equipment failure. Summary of the Invention

[0005] The technical problem to be solved by this application is: to overcome the shortcomings of the existing technology and provide a vacuum plasma treatment device and treatment method for the leukocyte removal filter body. This application uses vacuum plasma technology to modify the liquid inlet and discharge ports of the leukocyte removal filter, significantly improving the bonding strength of the adhesive interface with the polyvinyl chloride pipeline, and effectively solving the hidden danger of interface separation during wet heat sterilization.

[0006] The technical solution adopted by this application to solve the problems existing in the prior art is:

[0007] A vacuum plasma processing device for a leukocyte removal filter body comprises a placement rack assembly, a conveyor belt and plasma processing equipment.

[0008] The display rack assembly is placed on the conveyor belt and is used for vertically displaying a plurality of leukocyte removal filters, with the connection ports of the liquid inlet end or the liquid outlet end of the leukocyte removal filters arranged vertically upward.

[0009] A horizontally arranged bottom linear module is provided at each end of the conveyor belt in the width direction. A column is fixed on the sliding part of the two bottom linear modules. A top linear module is jointly mounted on the top of the two columns. The sliding part of the top linear module is fixedly connected to the plasma nozzle of the plasma treatment equipment, and the plasma nozzle is arranged vertically downward.

[0010] Preferably, the display rack assembly includes a plurality of placement tables arranged in parallel, and the placement tables include a circular frame, and a plurality of sliding locking devices are slidingly provided in the middle of the circular frame, and a leukocyte removal filter is clamped between two adjacent sliding locking devices.

[0011] Preferably, a slideway is provided on the edge frame in the length direction of the circular frame.

[0012] The sliding locking device comprises a vertical plate, and a first sliding block is fixed to each of the two ends of the vertical plate. The first sliding block is slidably arranged inside the slideway.

[0013] Preferably, a first push rod is protruding from the front end of the vertical plate, and the end of the first push rod abuts against the leukocyte removal filter.

[0014] Preferably, the vertical plate is provided with a second slot with an open upper end, and the protrusion of the liquid outlet end of the leukocyte removal filter is clamped in the second slot.

[0015] Preferably, the front end of the circular frame is fixedly connected to a fixing block, and the fixing block is provided with a first slot with an open upper end.

[0016] A locking block is slidably provided at the rear end of the middle channel of the circular frame, and a second sliding block fixedly connected at both ends of the locking block is slidably provided inside the slideway.

[0017] A nut sleeve is fixed to the rear end of the return frame, a screw rod threadedly connected to the nut sleeve is passed through the interior of the nut sleeve, and the front end of the screw rod is passed through the interior of the locking block, and the two are rotatably connected.

[0018] Preferably, the display rack assembly includes a box body, and a vertical plate is respectively provided at the front and rear ends above the box body, and the display rack assembly is arranged between the two vertical plates.

[0019] Preferably, the front end of the circular frame is fixedly connected to the first gear via a connecting shaft, the connecting shaft passes through the through hole of the front end vertical plate, and the first gear is arranged at the front end of the vertical plate.

[0020] A first sliding rod is fixed to the rear end of the screw rod. The first sliding rod passes through the through hole of the rear end vertical plate. The screw rod is coaxially arranged with the first gear.

[0021] A driving assembly is provided at the front end of the box body, and the driving assembly drives the first gear to rotate.

[0022] Preferably, a support device and a support device adjustment assembly are provided inside the box body.

[0023] The supporting device includes a plurality of vertically arranged supporting rods. When the circular frame is in a horizontal state, the top surfaces of the supporting rods abut against the bottom surface of the circular frame.

[0024] The support device adjustment assembly controls the up and down movement of the support rod.

[0025] A vacuum plasma treatment method for a leukocyte removal filter body is provided, based on the above-mentioned vacuum plasma treatment device for a leukocyte removal filter body, and comprises the following steps:

[0026] S01. Place several leukocyte removal filters vertically in the middle channel of the circular frame. The frame of the circular frame in the length direction supports the leukocyte removal filters. The protrusions of the liquid outlet ends of the leukocyte removal filters are inserted into the corresponding first and second slots. Rotate the screw and push each sliding locking device in turn through the sliding of the locking block to clamp each leukocyte removal filter.

[0027] S02. Place the rack assembly on the conveyor belt, which drives the rack assembly forward until it moves below the plasma nozzle.

[0028] S03. The conveyor belt stops running, and the plasma nozzle performs plasma modification on the port of the leukocyte removal filter. The bottom linear module and the top linear module drive the plasma nozzle to move and change its position, thereby modifying the port of each leukocyte removal filter.

[0029] S04. After the ports at one end of all leukocyte removal filters in the placement rack assembly have been modified, the support device adjustment assembly controls the support rod to move downward, releasing the contact with the return frame. The drive assembly drives the first gear to rotate, thereby driving the placement table as a whole to rotate degrees, so that the ports at the other end of the leukocyte removal filter are arranged upward, the support rod moves upward, and contacts the return frame. The plasma nozzle modifies the ports of the leukocyte removal filter.

[0030] S05. After the modification of both ends of the leukocyte removal filter is completed, the conveyor belt starts to move the display rack assembly forward.

[0031] Compared with the prior art, this application has the following beneficial effects:

[0032] (1) The end of the leukocyte removal filter made of PP material was modified by plasma to increase its reliability after gluing with the PVC pipe, effectively eliminating the separation of the two during the subsequent wet heat sterilization.

[0033] (2) Plasma modification can be performed on leukocyte removal filters in batches to improve efficiency.

[0034] (3) Avoiding secondary filling of the leukocyte removal filter, the placement table can be rotated 180 degrees, and the inlet and outlet ports on both sides of the leukocyte removal filter can be plasma modified without the need for secondary filling, thereby improving the overall efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The present application is further described below with reference to the accompanying drawings and examples.

[0036] Figure 1 This is a structural diagram of a vacuum plasma treatment device for a leukocyte removal filter body in this application.

[0037] Figure 2 for Figure 1 Front view of

[0038] Figure 3 This is a structural diagram of the connection between the rack assembly and the power supply assembly in a vacuum plasma treatment device for a leukocyte removal filter body according to the present application;

[0039] Figure 4 for Figure 3 Front view of

[0040] Figure 5 This is a structural diagram of the rack assembly with a leukocyte removal filter installed for this application.

[0041] Figure 6 This is the first structural diagram of the rack assembly without the leukocyte removal filter installed in this application.

[0042] Figure 7 This is the second structural diagram of the rack assembly without the leukocyte removal filter installed in this application.

[0043] Figure 8 This is the internal structure diagram of the rack assembly box for this application.

[0044] Figure 9 This is the support device adjustment assembly in the display rack assembly of this application.

[0045] Figure 10 This is the structure diagram of the placement table in the placement rack assembly for this application.

[0046] Figure 11 This is the first structural diagram of the single-unit placement platform in the placement rack assembly of this application.

[0047] Figure 12 This is the second structural diagram of the single-unit placement platform in the placement rack assembly of this application.

[0048] Figure 13 for Figure 11 Exploded diagram of

[0049] Figure 14 This is the structural diagram of the power supply assembly for this application.

[0050] In the figure: 1-box body, 101-bearing seat, 2-vertical plate, 3-return frame, 301-slide, 302-first gear, 4-fixed block, 401-first slot, 5-sliding locking device, 501-vertical plate, 502-second slot, 503-first push rod, 504-first slider, 6-locking block, 601-second slider, 602-second push rod, 7-nut sleeve, 8-screw, 801-first slide rod, 9-tooth plate, 10-first telescopic device, 11-electrical column, 12-electric control box, 13-support rod, 14-connecting plate, 15-first spring, 16-spring base, 1 7-longitudinal connecting plate, 18-transverse connecting plate, 1801-slide groove, 19-oblique rod, 1901-third slider, 20-rotating rod, 2001-second gear, 21-return drive sleeve, 2101-rack portion, 22-second telescopic device, 23-leukocyte removal filter, 2301-liquid outlet end protrusion, 24-power connection plate, 2401-guide plate, 25-second slide rod, 26-second spring, 27-U-shaped frame, 2701-connecting seat, 28-transmission belt, 2801-limit baffle, 29-bottom linear module, 30-column, 31-top linear module, 32-plasma nozzle. DETAILED DESCRIPTION

[0051] The vacuum plasma treatment device and treatment method for the leukocyte removal filter body of the present application are further described in detail with reference to the accompanying drawings, but are not intended to limit the present application.

[0052] Depend on Figures 1 to 14 As shown, a vacuum plasma treatment device for a leukocyte removal filter body includes a rack assembly, a conveyor belt 28 and a plasma treatment device. The conveyor belt 28 and the plasma treatment device both adopt existing technologies.

[0053] The rack assembly is placed on the conveyor belt 28 and is used to vertically place a plurality of leukocyte depletion filters 23 , with the connection ports of the liquid inlet or liquid outlet of the leukocyte depletion filters 23 arranged vertically upward.

[0054] A horizontally arranged bottom linear module 29 is located at each end of the conveyor belt 28's width. A column 30 is fixed to the sliding portion of each bottom linear module 29. A top linear module 31 is mounted on top of each column 30. The sliding portion of the top linear module 31 is fixedly connected to the plasma head 32 of the plasma treatment equipment, which is arranged vertically downward. Both the bottom linear module 29 and the top linear module 31 are electric linear modules, with the top linear module 31 mounted horizontally above the conveyor belt 28. An electric telescopic rod can be installed between the sliding portion of the plasma head 32 and the top linear module 31. This rod can drive the plasma head 32 up and down, changing its distance from the leukocyte removal filter 23 and thereby optimizing the plasma modification effect.

[0055] The display rack assembly includes a plurality of placement tables arranged in parallel, each of which includes a circular frame 3 , wherein a plurality of sliding locking devices 5 are slidingly provided in the middle of the circular frame 3 , and a leukocyte removal filter 23 is clamped between two adjacent sliding locking devices 5 .

[0056] The longitudinal side of the circular frame 3 is provided with a slideway 301 . The sliding locking device 5 comprises a vertical plate 501 , and a first slider 504 is fixed to each end of the vertical plate 501 . The first slider 504 is slidably arranged inside the slideway 301 .

[0057] In order to extend the distance between two adjacent leukocyte-removing filters 23 and avoid affecting the adjacent leukocyte-removing filters 23 when modifying one leukocyte-removing filter 23, a first push rod 503 is protruded from the front end of the vertical plate 501, and the end of the first push rod 503 abuts against the leukocyte-removing filter 23.

[0058] In order to ensure that the leukocyte removal filter 23 is arranged vertically with its port facing vertically upward, the vertical plate 501 is provided with a second slot 502 with an open upper end, and the liquid outlet protrusion 2301 of the leukocyte removal filter 23 is clamped inside the second slot 502.

[0059] In order to clamp the leukocyte removal filter 23 , the front end of the circular frame 3 is fixedly connected to a fixing block 4 , and the fixing block 4 is provided with a first slot 401 with an open upper end.

[0060] A locking block 6 is provided at the rear end of the middle channel of the circular frame 3 for sliding movement. A second slider 601 fixedly connected at both ends of the locking block 6 is slidably provided inside the slideway 301 . A second push rod 602 is provided at one end of the locking block 6 facing the sliding locking device 5 .

[0061] A nut housing 7 is fixed to the rear end of the circular frame 3. A screw 8 is threadedly connected to the nut housing 7. The front end of the screw 8 is inserted into the locking block 6, and the two are rotatably connected. Rotation of the screw 8 causes the locking block 6 to slide, thereby clamping the leukocyte depletion filter 23 through the sliding locking device 5 and the fixed block 4.

[0062] Since both the inlet and outlet ports on both sides of the leukocyte depletion filter 23 need to be plasma modified, and to avoid refilling the leukocyte depletion filter 23, the placement table needs to be able to rotate 180 degrees. To achieve this function, the placement rack assembly includes a box body 1, with a vertical plate 2 respectively provided at the front and rear ends of the box body 1, and the placement rack assembly is arranged between the two vertical plates 2.

[0063] The front end of the circular frame 3 is fixedly connected to a first gear 302 via a connecting shaft that passes through a through-hole in the front upright plate 2. The first gear 302 is mounted on the front end of the upright plate 2. A first slide bar 801 is fixed to the rear end of the screw rod 8, which passes through a through-hole in the rear upright plate 2. The screw rod 8 and the first gear 302 are coaxially arranged. A drive assembly is provided at the front end of the box body 1, which drives the first gear 302 to rotate.

[0064] The length of the first slide bar 801 is greater than the distance of unidirectional movement of the locking block 6, so as to prevent the first slide bar 801 from being separated from the vertical plate 2. The end of the first slide bar 801 away from the screw rod 8 is provided with a rotation device, such as an inner hexagonal slot or an outer hexagonal block or a rotating handle, to facilitate the rotation of the screw rod 8.

[0065] In this embodiment, the drive assembly includes a toothed plate 9 and a first telescopic device 10. The toothed plate 9 meshes with each first gear 302. The telescopic rod of the first telescopic device 10 pulls the toothed plate 9, which in turn rotates the first gear 302, thereby driving the placement table to achieve a 180-degree rotation. The first telescopic device 10 utilizes an electric cylinder, which is conventional technology. The first telescopic device 10 is fixedly connected to the outer wall of the box body 1.

[0066] Since both ends of the placement table are rotatably connected to the vertical plate 2 and can rotate, in order to prevent the leukocyte removal filter 23 from rotating in its normal state, causing the port to not face vertically upward, thereby affecting the plasma modification effect, in this embodiment, the box body 1 is provided with a support device and a support device adjustment assembly.

[0067] The support device includes several vertically arranged support rods 13. When the circular frame 3 is in a horizontal position, the top surface of the support rods 13 abuts the bottom surface of the circular frame 3. The arrangement of the support rods 13 prevents the placement table from rotating. When the placement table needs to rotate, the support device adjustment assembly controls the support rods 13 to move downward to avoid interference.

[0068] Specifically, the support rods 13 at one end of the same placement platform are fixedly connected by a common connecting plate 14. The connecting plates 14 under all placement platforms are fixedly connected by a plurality of longitudinal connecting plates 17 and transverse connecting plates 18. A spring base 16 is provided at the bottom of the box body 1. A first spring 15 is provided between the spring base 16 and the connecting plate 14. Under the action of the first spring 15, the upper end of the support rod 13 abuts the bottom surface of the circular frame 3.

[0069] The support device driving assembly includes two parallel rotating rods 20, each end of which is provided with an inclined rod 19 vertically connected thereto, a third slider 1901 is provided at the end of the inclined rod 19, and a slide groove 1801 is provided on the transverse connecting plate 18, and the third slider 1901 is slidably arranged inside the slide groove 1801.

[0070] A second gear 2001 is provided in the middle of the rotating rod 20 , and both ends of the rotating rod 20 are rotatably connected to the bearing seat 101 , and the bearing seat 101 is fixedly connected to the bottom surface of the box body 1 .

[0071] The support device drive assembly also includes an electrically controlled second telescopic device 22. The end of the telescopic rod of the second telescopic device 22 is connected to a circular drive sleeve 21, which is mounted on the second gears 2001 of the two rotating rods 20. The circular drive sleeve 21 has a rack portion 2101 on the upper and lower end surfaces, respectively, which meshes with the two second gears 2001.

[0072] In the free state, the support rod 13 moves upward under the action of the first spring 15, providing support for the horizontally arranged circular frame 3. When the circular frame 3 needs to be rotated, the telescopic rod of the second telescopic device 22 moves, pushing the circular drive sleeve 21, which in turn rotates the two second gears 2001. The rotating rod 20 rotates, causing the diagonal rod 19 to move downward, pulling the connecting plate 14 and the support rod 13 downward through the transverse connecting plate 18, leaving space for the circular frame 3 to rotate.

[0073] The box body 1 is provided with an electric control box 12, which controls the operation of the first telescopic device 10. The electric control box 12 includes a control module and a signal receiving module, both of which are prior art. In order to power the electric control box 12 and the first telescopic device 10, the following two methods can be used:

[0074] The first type is that a power module is provided inside the box body 1 , the power module adopts a battery, and the power module is electrically connected to the electric control box 12 .

[0075] The second type is that two power connection posts 11 are protruding from the bottom of the box body 1 . The two power connection posts 11 represent the positive and negative poles of the power supply respectively, and the power connection posts 11 are connected to the electric control box 12 .

[0076] Two power supply assemblies are connected to the frame of the conveyor belt 28, and the two power supply assemblies are respectively connected to the positive and negative poles of the external power supply. The two power supply assemblies are respectively connected to the two power posts 11. Furthermore, the power supply assembly includes two oppositely arranged power connection plates 24, and a second slide bar 22 is provided on the back of the power connection plates 24. The two power connection plates 24 are slidably arranged inside a U-shaped frame 27 with an opening facing upward, and the end of the second slide bar 22 passes through the side plate of the U-shaped frame 27 and is provided with a limit plate. A second spring 26 is sleeved on the second slide bar 22 located inside the U-shaped frame 27. The bottom of the U-shaped frame 27 is fixedly connected to the frame of the conveyor belt 8 through a connecting seat 2701.

[0077] When the conveyor belt 28 transports the display rack assembly to the power supply assembly position, the power post 11 is inserted between the two power connection plates 24 from the gap at the ends of the two power connection plates 24. Under the push of the second spring 26, the two power connection plates 24 clamp the power post 11 to achieve conductive connection.

[0078] To facilitate insertion of the power posts 11, guide plates 2401 are angled outward at the ends of the power strips 24, creating a V-shaped opening at the ends of the two power strips 24. To enhance electrical reliability, the power posts 11 are rectangular with semicircular ends. The power posts 11 are located on either side of the conveyor belt 28, with the bottom surface of the box body 1 abutting the belt.

[0079] A stopper 2801 is provided on either side of the conveyor belt 28 in the width direction, allowing the box body 1 to move between the two stoppers 2801 to prevent deviation and ensure that the power supply post 11 can be inserted between the two power supply plates 24 of the power supply assembly. A through-beam photoelectric sensor is installed on the stopper 2801 to detect the position of the display rack assembly. When the display rack assembly is in place, it is located within the active area of the plasma shower head 32, and the power supply post 11 is electrically connected to the power supply plates 24.

[0080] A vacuum plasma treatment method for a leukocyte removal filter body is provided, based on the above-mentioned vacuum plasma treatment device for a leukocyte removal filter body, and comprises the following steps:

[0081] S01. Place several leukocyte removal filters 23 vertically in the middle channel of the circular frame 3. The longitudinal side frames of the circular frame 3 support the leukocyte removal filters 23. Insert the liquid outlet protrusions 2301 of the leukocyte removal filters 23 into the corresponding first slots 401 and second slots 502. Rotate the screw 8, and the sliding locking devices 5 are pushed in sequence by the sliding of the locking blocks to clamp the leukocyte removal filters 23.

[0082] S02, placing the display rack assembly on the conveyor belt 28, and the conveyor belt 28 drives the display rack assembly forward until it moves below the plasma shower head 32;

[0083] S03, the conveyor belt 28 stops running, and the plasma nozzle 32 performs plasma modification on the ports of the leukocyte removal filter 23. The bottom linear module 29 and the top linear module 31 drive the plasma nozzle 32 to move and change its position, thereby modifying the ports of each leukocyte removal filter 23.

[0084] S04. When the ports on one end of all leukocyte depletion filters 23 in the placement rack assembly have been modified, the support device adjustment assembly controls the support rod 13 to move downward, releasing the contact with the circular frame 3. The drive assembly drives the first gear 302 to rotate, thereby causing the placement rack to rotate 180° as a whole, so that the ports on the other end of the leukocyte depletion filters 23 face upward. The support rod 13 moves upward, contacting the circular frame 3, and the plasma nozzle 32 modifies the ports of the leukocyte depletion filters 23.

[0085] S05. After the modification of both ends of the leukocyte removal filter 23 is completed, the conveyor belt 28 starts to move the display rack assembly forward.

[0086] The principle of improving the reliability of the connection between the PP leukocyte removal filter 23 and the PVC pipe by plasma modification is as follows:

[0087] The non-polar surface of PP material can lead to weak interfacial bonding during direct bonding due to insufficient intermolecular forces. Vacuum plasma treatment bombards the PP surface with high-energy particles, forming polar functional groups such as hydroxyl (-OH) and carboxyl (-COOH) groups, enhancing chemical bonding with the adhesive. Etching also creates a nanoscale rough structure, improving mechanical intercalation. This increases the surface energy of PP from 30mN / m to over 70mN / m, achieving wettability compatible with the adhesive.

[0088] The difference in thermal expansion coefficients between PP and PVC is the main cause of interfacial delamination during sterilization. The adhesive interface modified by plasma has the following stress resistance properties:

[0089] The polar groups form covalent bonds with the adhesive, increasing the bond energy; the roughened surface releases thermal expansion stress along a multi-level microstructure gradient, avoiding local stress concentration; the modified layer maintains chemical stability in a high-temperature steam environment, preventing the adhesive layer from hydrolyzing and breaking.

[0090] The above describes the implementation methods of the present application in detail in conjunction with the accompanying drawings, but the present application is not limited to the above implementation methods. Various changes can be made within the scope of knowledge possessed by ordinary technicians in the relevant technical field without departing from the purpose of the present application.

Claims

1. A vacuum plasma treatment device for a leukocyte removal filter body, characterized in that: It includes a rack assembly, a conveyor belt (28) and plasma processing equipment; The rack assembly is placed on the conveyor belt (28) and is used to vertically place a plurality of leukocyte removal filters (23), with the connection ports of the liquid inlet end or the liquid outlet end of the leukocyte removal filter (23) arranged vertically upward; A horizontally arranged bottom linear module (29) is provided at each end of the width direction of the conveyor belt (28), a column (30) is fixed on the sliding part of the two bottom linear modules (29), a top linear module (31) is jointly supported on the top of the two columns (30), the sliding part of the top linear module (31) is fixedly connected to the plasma nozzle (32) of the plasma treatment equipment, and the plasma nozzle (32) is arranged vertically downward.

2. The vacuum plasma treatment device for a leukocyte removal filter according to claim 1, characterized in that: The placement rack assembly comprises a plurality of placement tables arranged in parallel, wherein the placement tables comprise a circular frame (3), wherein a plurality of sliding locking devices (5) are slidingly provided in the middle of the circular frame (3), and a leukocyte removal filter (23) is clamped between two adjacent sliding locking devices (5).

3. The vacuum plasma treatment device for a leukocyte removal filter according to claim 2, characterized in that: A slideway (301) is provided on the edge frame in the longitudinal direction of the circular frame (3); The sliding locking device (5) comprises a vertical plate (501), and a first sliding block (504) is fixed to each of the two ends of the vertical plate (501). The first sliding block (504) is slidably arranged inside the slideway (301).

4. The vacuum plasma treatment device for a leukocyte removal filter according to claim 3, characterized in that: A first push rod (503) is protruding from the front end of the vertical plate (501), and the end of the first push rod (503) abuts against the leukocyte removal filter (23).

5. The vacuum plasma treatment device for a leukocyte removal filter according to claim 3 or 4, characterized in that: The vertical plate (501) is provided with a second slot (502) with an open upper end, and the liquid outlet protrusion (2301) of the leukocyte removal filter (23) is clamped inside the second slot (502).

6. The vacuum plasma treatment device for the leukocyte removal filter body according to claim 5, characterized in that: The front end of the return frame (3) is fixedly connected to a fixed block (4), and the fixed block (4) is provided with a first slot (401) with an open upper end; A locking block (6) is slidably provided at the rear end of the middle channel of the return frame (3), and a second sliding block (601) fixedly connected to both ends of the locking block (6) is slidably provided inside the slideway (301); A nut sleeve (7) is fixed to the rear end of the return frame (3), a screw rod (8) threadedly connected to the nut sleeve (7) is passed through the interior of the nut sleeve (7), and the front end of the screw rod (8) is passed through the interior of the locking block (6), and the two are rotatably connected.

7. The vacuum plasma treatment device for the leukocyte removal filter body according to claim 6, characterized in that: The display rack assembly comprises a box body (1), wherein a vertical plate (2) is respectively provided at the front and rear ends above the box body (1), and the display rack assembly is arranged between the two vertical plates (2).

8. The vacuum plasma treatment device for the leukocyte removal filter body according to claim 7, characterized in that: The front end of the return frame (3) is fixedly connected to a first gear (302) via a connecting shaft, the connecting shaft passes through a through hole of the front end vertical plate (2), and the first gear (302) is arranged at the front end of the vertical plate (2); A first slide bar (801) is fixed to the rear end of the screw rod (8), and the first slide bar (801) passes through the through hole of the rear end vertical plate (2). The screw rod (8) and the first gear (302) are coaxially arranged; A driving assembly is provided at the front end of the box body (1), and the driving assembly drives the first gear (302) to rotate.

9. The vacuum plasma treatment device for a leukocyte removal filter according to claim 6, characterized in that: The box body (1) is provided with a support device and a support device adjustment assembly inside; The supporting device comprises a plurality of vertically arranged supporting rods (13). When the return frame (3) is in a horizontal state, the top surface of the supporting rods (13) abuts against the bottom surface of the return frame (3); The support device adjustment assembly controls the support rod (13) to move up and down.

10. A method for vacuum plasma treatment of a leukocyte depletion filter body, based on the vacuum plasma treatment device for a leukocyte depletion filter body according to claim 9, characterized in that: The following steps are involved: S01. Place a plurality of leukocyte-removing filters (23) vertically in the middle channel of the circular frame (3). The frame of the circular frame (3) in the longitudinal direction supports the leukocyte-removing filters (23). Insert the protrusion (2301) of the liquid outlet end of the leukocyte-removing filter (23) into the corresponding first slot (401) and the second slot (502). Rotate the screw (8) and push each sliding locking device (5) in turn by sliding the locking block to clamp each leukocyte-removing filter (23). S02, placing the rack assembly on the conveyor belt (28), and the conveyor belt (28) drives the rack assembly to move forward until it moves below the plasma nozzle (32); S03, the conveyor belt (28) stops running, and the plasma nozzle (32) performs plasma modification on the ports of the leukocyte removal filter (23), and the plasma nozzle (32) is driven to move by the bottom linear module (29) and the top linear module (31), and its position is changed, thereby achieving modification of the ports of each leukocyte removal filter (23); S04. When the ports at one end of all the leukocyte-removing filters (23) in the placement rack assembly are modified, the support device adjustment assembly controls the support rod (13) to move downward, releasing the contact with the return frame (3), and the drive assembly drives the first gear (302) to rotate, thereby driving the placement rack as a whole to rotate 180 degrees, so that the ports at the other end of the leukocyte-removing filters (23) are arranged upward, the support rod (13) moves upward, contacts the return frame (3), and the plasma nozzle (32) modifies the ports of the leukocyte-removing filters (23); S05. After the modification of both ends of the leukocyte removal filter (23) is completed, the conveyor belt (28) is operated to move the display rack assembly forward.

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