Nasal dispensing head for fluid product

Abstract

The invention relates to a dispensing head (10) for nasal dispensing of a fluid product, the head comprising a body (11) provided with a dispensing hole (12), the body (11) forming a reservoir (13, 14) containing a dose of a fluid product; a piston (20) sliding in a portion of the reservoir to dispense the dose of fluid product through the dispensing orifice (12), the dispensing head (10) comprising a member to first dispense the dose of fluid product in the form of a first fluid region inscribed in a first cylinder having a diameter D1, and to second fluid region inscribed in a second cylinder having a diameter D2, the piston (20) sliding in a portion of the reservoir to dispense the dose of fluid product through the dispensing orifice (12). The dose of fluid product is then dispensed after a distance L from the dispensing hole (12) in the form of a second fluid region following a second cylinder having a diameter D2, where D2 gt; d1, said reservoir comprising a first distal cylindrical portion (13) having a length l1 and a diameter d1 and a second proximal cylindrical portion (14) having a length l2 and a diameter d2, where d1 gt; the present invention relates to a method for producing a polymer, comprising the steps of: (1) forming a polymer, (2) having a diameter (d1) of 2 mm to 14 mm, preferably 2.9 mm to 12.5 mm, (2) having a diameter (d2) of 1 mm to 7 mm, preferably 2 mm to 6 mm, and a ratio (d2 / d1) of 0.3 to 0.8, preferably 0.4 to 0.7.

Description

[0001] The present invention relates to a nasal dispenser head for a fluid product and a device comprising such a dispenser head.

[0002] Nasal dispensing devices are well known. They generally comprise a reservoir containing one or more doses of a fluid product and a dispensing head that is movable relative to the reservoir to dispense the fluid product, in particular via a pump, a metering valve, or a piston sliding in the reservoir. When a user wishes to use the device, they insert the dispensing head into their nostril and activate the device to dispense a dose of the fluid product, typically in the form of a spray.

[0003] A drawback of prior art devices concerns the effectiveness of the dose delivered to the nostrils, particularly when the fluid product being delivered is intended to act on the brain. Indeed, with this type of treatment, only a small fraction of the dose typically reaches the target area, namely the olfactory area, including the ethmoid sinuses, due in particular to the shape of the intra-nostril spray, which is conical at the device's outlet. However, this conical shape does not appear to be optimal for achieving maximum deposition in the target area.

[0004] Documents US1155608 and WO2018109409A1 describe nasal inhalation devices that use external positioning devices to correctly orient the dispenser head in the user's nostrils. This embodiment improves the deposition of the fluid product on the target area, but this improvement is still limited due to the conical shape of the spray at the outlet of the device.

[0005] Documents US2017360831, US2011297145, WO2021069972, WO2021066195 and WO2016034803 describe other prior art devices, but none of these documents allow for the production of a dispensed fluid with two distinct fluid zones, wherein the second fluid zone is widened relative to the first fluid zone.

[0006] The object of the present invention is to provide a nasal dispensing head and a device comprising such a head which do not suffer from the above-mentioned disadvantages.

[0007] The present invention has for its object in particular to provide a nasal dispensing head and a device comprising such a head which improve the deposition rate of the active product on the olfactory area and / or on the ethmoid sinuses.

[0008] The invention also aims to provide a nasal dispensing head and a device comprising such a head which allow the shape of the spray in the nostrils to be controlled.

[0009] Another object of the present invention is to provide a nasal dispensing head and a device comprising such a head, which are simple and inexpensive to manufacture and assemble.

[0010] The present invention therefore provides a nasal dispenser head for a fluid product, comprising a body provided with a dispensing orifice, said body forming a reservoir containing a dose of fluid product; a piston that slides in a portion of said reservoir to dispense said dose of fluid product through said dispensing orifice, said dispenser head comprising a member that first dispenses said dose of fluid product in the form of a first fluid area inscribed in a first cylinder having a diameter D1 and then, after a distance L from said dispensing orifice, dispenses said dose of fluid product in the form of a second fluid area inscribed in a second cylinder having a diameter D2, wherein D2>D1, said reservoir comprising a first distal cylindrical portion having a length l1 and a diameter d1 and a second proximal cylindrical portion having a length l2 and a diameter d2, wherein d1>d2, said diameter d1 being between 2 mm and 14 mm, preferably between 2.9 mm and 12.5 mm, said diameter d2 being between 1 mm and 7 mm, preferably between 2 mm and 6 mm, and the ratio d2 / d1 being between 0.3 and 0.8, preferably between 0.4 and 0.7.

[0011] Advantageously, said second proximal cylindrical portion extends said first distal cylindrical portion and forms said dispensing orifice at its axial end.

[0012] Advantageously, said second proximal cylindrical portion extends coaxially with said first distal cylindrical portion along the longitudinal axis of said dispenser head.

[0013] Advantageously, said piston is configured to slide in said first distal cylindrical portion between a rest position and an actuated position.

[0014] Advantageously, said piston comprises a front extension which, in the actuated position, occupies the volume of said second proximal cylindrical portion.

[0015] Advantageously, the length l1 is 3 mm to 20 mm, preferably 4 mm to 19 mm.

[0016] Advantageously, the length l2 is 3 mm to 18 mm, preferably 5 mm to 15 mm.

[0017] Advantageously, the actuation force F of the piston is between 10N and 25N, preferably between 12N and 22N.

[0018] Advantageously, the volume V of the dose of fluid dispensed is between 0.02 ml and 5 ml.

[0019] Advantageously, said diameter D1 is between 1 mm and 3 mm, in particular approximately 2 mm.

[0020] Advantageously, the diameter D2 is 3.5 mm to 50 mm, in particular 5 mm to 20 mm.

[0021] Advantageously, the ratio D1 / D2 is between 0.05 and 0.8, in particular between 0.1 and 0.4.

[0022] Advantageously, the first fluid region forms a substantially axial jet through the outlet orifice, and the second fluid region forms a substantially conical spray, the substantially conical spray forming an angle α.

[0023] The invention also provides a device for nasal dispensing of a fluid product, comprising a dispensing head as described above.

[0024] These and other features and advantages will become more apparent in the following detailed description, which is given by way of non-limiting example with reference to the accompanying drawings, in which:

[0025] Figure 1 is a schematic cross-sectional view of a nasal dispensing tip according to a first advantageous embodiment inserted into a nostril;

[0026] Figure 2 yes Figure 1 A schematic cross-sectional view of a dispensing head in an actuated position showing the fluid region downstream of the dispensing orifice;

[0027] Figure 3 yes Figure 2 A schematic cross-sectional view of a dispensing head in an actuated position showing an advantageous spray shape downstream of the dispensing orifice;

[0028] Figure 4 is in a stationary position Figure 2 and Figure 3 A schematic cross-sectional view of a dispensing head;

[0029] Figure 5 is with Figure 4 a similar view in the actuated position;

[0030] Figure 6 is a schematic cross-sectional view of a nasal dispensing head according to a second advantageous embodiment;

[0031] Figure 7 is with Figure 6 A similar view in the actuated position, and

[0032] Figures 8 to 10 The distributions of three fluids of different viscosities are shown.

[0033] In this specification, the terms "axial" and "radial" are relative to the longitudinal axis X of the device, e.g. Figure 2 and Figure 3 The terms "proximal end" and "distal end" refer to the dispensing orifice.

[0034] Figure 1 a cross-sectional view of the nostril is shown; the roof P of the nasal cavity can be seen, which includes the ethmoid sinuses E. In front of this roof P are the nasal valves and turbinates, the presence of which makes it difficult to access the ethmoid sinuses E with conventional sprays that extend conically at the outlet of the dispensing orifice 12.

[0035] A dispenser head 10 comprising a body 11 provided with a dispenser orifice 12 is inserted into the nostril to dispense a dose of fluid during actuation. The dispenser head 10 contains a fluid reservoir in a portion of which a piston 20 slides axially to dispense the fluid through the dispenser orifice.

[0036] The piston 20 is connected to an actuation rod 25 which can be manually actuated by a user.

[0037] Alternatively, the dispenser head 10 can be integrated into a dispenser device comprising a dispenser member, such as a preloaded spring, adapted to act on the actuation lever 25, in particular upon a user command, such as an appropriate control button, to trigger the actuation of the spring. This solution has the advantage of always delivering the same actuation force, so that the nature of the spray produced during actuation is independent of the way in which the user actuates the device.

[0038] According to the invention, the fluid product is first dispensed in the form of a first fluid area inscribed in a first cylinder with a diameter D1, and then, after a distance L from the dispenser orifice 12, transforms into a second fluid area inscribed in a second cylinder with a diameter D2, where D2>D1.

[0039] Advantageously, from Figure 3 As can be seen in FIG. 1 , the fluid product is first distributed in the form of an approximately axial jet and then transforms into an approximately conical spray after a distance L from the dispensing orifice 12 .

[0040] from Figure 1 As can be seen in the figure, the present invention allows the fluid product of the first fluid area to pass through the nasal valve and the nasal concha, for example in the form of a jet, before being transformed into a second fluid area of ​​larger diameter (for example, into a conical spray), which will allow it to reach the ethmoid sinus E in a more significant amount (the portion of the fluid dose that reaches the ethmoid sinus) and in a more significant surface (the surface S of the ethmoid sinus affected by the fluid product).

[0041] To achieve this particular form of dual fluid zone, the reservoir comprises a first distal cylindrical portion 13 having a length l1 and a diameter d1 and a second proximal cylindrical portion 14 having a length l2 and a diameter d2, wherein d1 > d2.

[0042] The second proximal cylindrical portion 14 extending the first distal cylindrical portion 13 forms the dispensing orifice 12 at its axial end, which therefore also has a diameter d2.

[0043] Preferably, the second proximal cylindrical portion 14 extends coaxially along the longitudinal axis X of the first distal cylindrical portion 13 .

[0044] The piston 20 is located in the first distal cylindrical portion 13. Figure 4 and Figure 6 The rest position shown is the same as Figure 5 and Figure 7 Slide between the actuation positions shown.

[0045] exist Figure 6 and Figure 7 In a second embodiment, the piston 20 comprises a front extension 21 which, in the actuated position, will occupy the volume of the second proximal cylindrical portion 14, thus reducing the dead volume before actuation and dispensing substantially the entire dose of the fluid product contained in the reservoirs 13, 14.

[0046] refer to Figure 2 and Figure 3 In the example of FIG. 1 , at the start of actuation, a first volume of fluid product contained in the second proximal cylindrical portion 14 is discharged through the dispensing orifice 12 at a speed V1 to form a first fluid area inscribed in a cylinder having a diameter D1.

[0047] exist Figure 3 In the example, the first fluid region forms an approximately straight jet.

[0048] By continuing the actuation stroke, the second volume of fluid contained in the first distal cylindrical portion 13 enters the second proximal cylindrical portion 14, wherein the diameter decreases from d1 to d2, causing the fluid to accelerate. Consequently, the second volume of fluid from the first distal cylindrical portion 13 is dispensed through the dispensing orifice 12 at a velocity V2 greater than V1.

[0049] Thus, this second, faster volume of fluid will catch up with the first, slower volume of fluid and hit it at a distance L from the dispensing orifice 12, which will produce an explosion and thus form a second fluid zone inscribed in a cylinder with diameter D2, where D2>D1.

[0050] exist Figure 3 In the example of , the second fluid region forms an approximately V-shaped spray defining an angle α.

[0051] Thus, the spray produced by the present invention includes the following important characteristics for the efficiency of the device: length L, diameters D1 and D2, and ultimately angle α when the second fluid region forms a nearly conical spray.

[0052] By varying the characteristics of the dispenser head 10, such as the lengths l1 and / or l2, the diameters d1 and / or d2, and / or the actuation characteristics of the piston (such as the actuation force of the piston 20 and / or its actuation speed), and / or the volume of the dispensed dose, these parameters L, D1, D2, and α can be varied and thus adapted to different subject types, nostril sizes, or shapes. In particular, the length L can be selected to produce a second, wider spray zone at the correct location, which must vary depending on the person being treated, adult / child, man / woman, ethnic origin, etc. Similarly, variations in the diameter D2 and / or angle α are permitted to adjust the surface S to be treated, which also varies depending on the person being treated. Adjustment of the parameters L, D1, D2, and / or α is also permitted to target areas of the nasal cavity other than the ethmoid sinuses, such as the nasal concha, if desired.

[0053] Another advantage of the present invention is that it is no longer necessary to insert the dispenser head 10 deeply into the nostril, but it may be sufficient to position the dispenser hole 12 at the entrance of the nostril, depending on the length L. Advantageously, in this case, the dispenser head 10 may include an insertion limiting member, for example, a radial protrusion arranged around the body 11 of the dispenser head 10 near the outlet hole 12, and which may cooperate with the wall of the nostril to limit insertion.

[0054] The dispensing head advantageously comprises the following features:

[0055] - length l1 is 3 mm to 20 mm, preferably 4 mm to 19 mm;

[0056] - a diameter d1 of 2 mm to 14 mm, preferably 2.9 mm to 12.5 mm;

[0057] - length l2 is 3 mm to 18 mm, preferably 5 mm to 15 mm;

[0058] The diameter d2 is from 1 mm to 7 mm, preferably from 2 mm to 6 mm.

[0059] Tests have shown that an important parameter for obtaining a spray as desired is the ratio of diameters d2 / d1. Advantageously, this ratio d2 / d1 is between 0.3 and 0.8, preferably between 0.4 and 0.7.

[0060] The combination of dimensions d1 and d2, and the above ratio d2 / d1, is required to achieve the desired effect of dispensing fluid with a dual fluid region (having a first narrow region and a second wide region).

[0061] When a preload spring is used to move the piston and perform actuation, the choice of spring force has an impact on the properties of the resulting spray. The actuation force or force F of the piston 20 is advantageously between 10 N and 25 N, preferably between 12 N and 22 N. Tests have shown that, while the characteristics of the dispenser head 10 (l1, d1, l2, d2) are constant, the force F is greater, the angle α is smaller, and the length L is greater.

[0062] The volume V of the dose of fluid dispensed is advantageously between 0.02 ml and 5 ml.

[0063] Thus, the length L can advantageously vary from 5 mm to 50 mm, the diameter D1 can advantageously vary from 1 mm to 3 mm, the diameter D2 can advantageously vary from 3.5 mm to 50 mm, the ratio D1 / D2 can advantageously vary from 0.05 to 0.8, and the angle α can advantageously vary from 15° to 125°. Advantageously, the diameter D1 is approximately 2 mm, the diameter D2 can vary from 5 mm to 20 mm, and the ratio D1 / D2 can vary from 0.1 to 0.4.

[0064] The following table shows the basis Figure 3 The examples form the different configurations of the fluid area that were tested (with water as the fluid product):

[0065]

[0066] Reservoirs particularly suitable for the present invention include the following features:

[0067] - Volume V = 0.2 ml

[0068] - Length l1 = 18.5 (± 0.15) mm;

[0069] - diameter d1 = 3.73 (± 0.01) mm;

[0070] - length l2 = 11.142 (± 0.11) mm;

[0071] - diameter d2 = 2.025 (± 0.004) mm;

[0072] -Ratio d2 / d1 = 0.54.

[0073] A spring particularly suitable for this reservoir is one having the following characteristics:

[0074] - Free length = 80 (± 2.5) mm;

[0075] - Length at the start of actuation = 23.5 mm;

[0076] - Length at the end of actuation = 32.8 mm;

[0077] - Force F at the start of actuation (spring only) = 19.8 (± 0.5) N;

[0078] - Force at the end of actuation F (spring only) = 16.5 (± 0.5) N;

[0079] -Stiffness (spring only) = 0.348 (N / mm);

[0080] - Force at the start of actuation F (assembled spring) = 18.9 (± 0.5) N;

[0081] - Force at the end of actuation F (assembled spring) = 12.9 (± 0.5) N;

[0082] This particular device was tested with three fluids of different viscosities, a first fluid (water) having a viscosity of 2 cP, a second fluid having a viscosity of 23 cP, and a third fluid having a viscosity of 80 cP. These tests have demonstrated that the less viscous the fluid, the better the spray according to the invention.

[0083] Figure 8 shows the spray obtained with the first fluid, Figure 9 shows the spray obtained with the second fluid, and Figure 10 The spray obtained with the third fluid is shown.

[0084] Deposition of the device in the olfactory region was tested in an artificial nostril ("nose cast") at different orientations, namely, horizontal angles AH (the angle between the longitudinal axis of the device and the horizontal plane) of 30°, 45°, and 60°, and vertical angles AV (the angle between the longitudinal axis of the device and a plane perpendicular to the face) of 0°, 5°, 10°, and 20°. The PI insertion depth was 10 or 15 mm.

[0085] The above test was repeated three times and the following results are given for the deposition rate in the olfactory area (the table contains the average of the three tests):

[0086] 1. First fluid (viscosity 2 cP):

[0087]

[0088] 2. Second fluid (viscosity 23 cP):

[0089]

[0090] 3. Third fluid (viscosity 80 cP):

[0091]

[0092] By comparison, a standard device that produces a cone-shaped spray directly at the outlet of the device has been tested:

[0093] 1. First fluid (viscosity 2 cP):

[0094]

[0095] 2. Second fluid (viscosity 23 cP):

[0096]

[0097] It can be seen that the present invention significantly increases the deposition rate in the olfactory area, from less than 10% for devices delivering conventional sprays, to over 50% in most cases with the present invention.

[0098] A commercially available syringe (Gerresheimer Gx® Bulk Luer Tapered Syringe 0.5 ml) was tested for comparison. This syringe had the following characteristics:

[0099] - Volume V = 0.5 ml

[0100] - Diameter d1 = 4.65 (± 0.1) mm;

[0101] - diameter d2 = 1.10 (± 0.1) mm;

[0102] -Ratio d2 / d1 = 0.24.

[0103] According to the invention, this syringe does not allow obtaining the dispensing of a fluid with a dual fluid zone.

[0104] This demonstrates the importance of the diameters d1 and d2, and in particular the ratio d2 / d1.

[0105] The present invention is particularly suitable for treating Parkinson's disease or Alzheimer's type neurodegenerative diseases, which require drug delivery through the nose-brain barrier. Reaching the target area (especially the ethmoid sinus) through the nasal cavity is a simple and non-invasive means of delivering treatment to the brain.

[0106] The present invention can be advantageously used with the following drugs:

[0107] - Neurotransmitters and neuromodulators, such as: acetylcholine (ACH), anticholinergics, adenosine triphosphate (ATP), aspartate (Asp), beta-amyloid, beta-endorphin, bradykinin, dopamine (DA), L-DOPA, carbidopa, epinephrine, dynorphin, endomorphin, enkephalin, 5-hydroxytryptamine (5-HT), sumatriptan, sumatriptan, dihydroergotamine, zolmitriptan, zolmig, gamma-aminobutyric acid (GABA), glutamate (glu), glycine, histamine, leptin, nerve growth factor and other growth factors, norepinephrine, nitric oxide, substance P;

[0108] - General anesthetics, such as alfentanil, desflurane, enflurane, etomidate, fentanyl, halothane, isoflurane, ketamine, methotrexate, methoxyflurane, midazolam, lorazepam, diazepam, morphine, nitrous oxide (N2O), propofol, sevoflurane, sufentanil, Sublimase, and thiopental sodium;

[0109] - Local anesthetics, such as benzocaine, bupivacaine, cocaine, lidocaine, prilocaine, procaine, ropivacaine, tetracaine;

[0110] - Opioid analgesics, agonist antagonists, and cough suppressants, such as: agonists, codeine, diphenoxylate, fentanyl, heroin and other opioids, hydrocodone, 1-alpha-acetyl-methadone, levomethadone, loperamide, meperidine, methadone, morphine, oxycodone, d-propoxyphene, combinations of opioids with acetaminophen and asa, tramadol;

[0111] -Agonists / antagonists and antagonists, such as: buprenorphine, butorphanol, nalbuphine, nalorphine, naloxone, naltrexone, nalmefene, pentazocine, codeine, dextromethorphan, hydrocodone;

[0112] - Medications used to treat Parkinson's disease and movement disorders, such as amantadine, apomorphine, baclofen, benzodiazepines, benztropine, bromocriptine, carbidopa, cyclobenzaprine, dantrolene, dopamine, entacapone, haloperidol, L-DOPA, pergolide, pramipexole, ropinirole, selegiline (deprenyl), trihexyphenidyl, rasagiline, acitraque, selegiline, radostigide, rotigotine, neupro, monoamine oxidase inhibitors, and COMT inhibitors;

[0113] - Antiepileptic drugs, such as acetazolamide, carbamazepine, clonazepam, diazepam, ethosuximide, felbamate, gabapentin, lamotrigine, lorazepam, phenobarbital, phenytoin, primidone, tiagabine, topiramate, valproic acid, vigabatrin, midazolam;

[0114] - Medications used for mood disorders, such as antidepressants, amitriptyline, bupropion, citalopram, clomipramine, desipramine, fluoxetine, fluvoxamine, imipramine, nortriptyline, paroxetine, phenelzine, sertraline, trazodone, tranylcypromine, venlafaxine, antimanic drugs, carbamazepine, lithium carbonate, valproic acid;

[0115] - Antipsychotics (neuroleptics), such as chlorpromazine (CPZ), clozapine, fluphenazine, haloperidol, olanzapine, quetiapine, risperidone, sertindole, thioridazine, thiothixene, and ziprasidone;

[0116] - sedatives-hypnotics, anxiolytics, and centrally acting muscle relaxants, such as alprazolam, chloral hydrate, diphenhydramine, flumazenil, flurazepam, hydroxyzine, lorazepam, oxazepam, phenobarbital, temazepam, triazolam, zaleplon, zolpidem;

[0117] -Medications used for anxiety disorders and skeletal muscle relaxants, such as alprazolam, chlorpheniramine potassium, clorazepate, diazepam, flumazenil (antagonist), lorazepam, oxazepam;

[0118] - Alzheimer's disease treatment, for example: donepezil, galantamine, rivastigmine, tacrine, detemir, Novolin, Humulin, insulin, insulin-like hormones, insulin analogs such as insulin NPH, insulin lispro, insulin aspart, insulin glulisine, insulin glargine, insulin degludec, BDNF, GDNF, MIBG, anticancer agents, anticancer drugs, dopamine agonists, dopamine antagonists;

[0119] - Other drugs, for example: amphetamine, caffeine, ephedrine, methamphetamine, methylphenidate, phentermine, sibutramine, disulfiram, ethanol, methanol, naltrexone, atropine, scopolamine, ketamine, lysergic acid diethylamide (LSD), MDMA (methylenedioxy-methamphetamine), mescaline, phencyclidine (PCP), donabinol, cannabis / THC, organic solvents, nicotine, pentobarbital, neuroprotective compounds, neuroprotective peptides, neuroprotective factors, davutide, antipsychotic drugs, antidepressants, ketamine, entacapone, anti-TDAH agents, anti-TDAH drugs such as methylphenidate (Ritalin), autism drugs and autism symptoms.

[0120] The invention has been described with reference to advantageous embodiments, but it is understood that any modifications may be provided by a person skilled in the art without departing from the scope of the invention as defined in the accompanying claims.

Claims

1. A nasal dispenser head (10) for a fluid product, comprising a body (11) provided with a dispensing orifice (12), said body (11) forming a reservoir (13, 14) containing a dose of the fluid product; a piston (20) sliding in a portion of said reservoir to dispense said dose of fluid product through said dispensing orifice (12), characterized in that The dispensing head (10) comprises a member which first dispenses the dose of fluid product in the form of a first fluid area inscribed in a first cylinder with a diameter D1 and then, after a distance L from the dispensing orifice (12), dispenses the dose of fluid product in the form of a second fluid area inscribed in a second cylinder with a diameter D2, wherein D2>D1, the reservoir comprising a first distal cylindrical portion (13) with a length l1 and a diameter d1 and a second proximal cylindrical portion (14) with a length l2 and a diameter d2, wherein d1>d2, the diameter d1 is between 2 mm and 14 mm, preferably between 2.9 mm and 12.5 mm, the diameter d2 is between 1 mm and 7 mm, preferably between 2 mm and 6 mm, and the ratio d2 / d1 is between 0.3 and 0.8, preferably between 0.4 and 0.

7.

2. Head according to claim 1, wherein said second proximal cylindrical portion (14) extends said first distal cylindrical portion (13) and forms said dispensing orifice (12) at its axial end.

3. Head according to claim 2, wherein said second proximal cylindrical portion (14) extends coaxially with said first distal cylindrical portion (13) along the longitudinal axis (X) of said dispensing head (10).

4. The head according to any of the preceding claims, wherein the piston (20) is configured to slide in the first distal cylindrical portion (13) between a rest position and an actuated position.

5. Head according to any of the preceding claims, wherein the piston (20) comprises a front extension (21) which, in the actuated position, occupies the volume of the second proximal cylindrical portion (14).

6. A head according to any one of the preceding claims, wherein the length l1 is 3 mm to 20 mm, preferably 4 mm to 19 mm.

7. A head according to any one of the preceding claims, wherein the length l2 is 3 mm to 18 mm, preferably 5 mm to 15 mm.

8. Head according to any of the preceding claims, wherein the actuation force F of the piston (20) is from 10N to 25N, preferably from 12N to 22N.

9. Head according to any one of the preceding claims, wherein the volume V of the dose of fluid product dispensed is between 0.02 ml and 5 ml.

10. Head according to any of the preceding claims, wherein the diameter D1 is 1 mm to 3 mm, in particular about 2 mm.

11. Head according to any of the preceding claims, wherein the diameter D2 is 3.5 mm to 50 mm, in particular 5 mm to 20 mm.

12. Head according to any of the preceding claims, wherein the ratio D1 / D2 is from 0.05 to 0.8, in particular from 0.1 to 0.

4.

13. A head according to any one of the preceding claims, wherein the first fluid region forms an approximately axial jet through the outlet orifice (12) and the second fluid region forms an approximately conical spray forming an angle α.

14. Device for nasal dispensing of fluid products, characterized in that The device comprises a dispensing head according to any one of the preceding claims.

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