Preparation method of phellinus igniarius compound granules

Abstract

The invention discloses a preparation method of phellinus igniarius compound granules. The invention particularly discloses a preparation method of phellinus igniarius compound granules. The preparation method comprises the following steps: mixing raw materials, carrying out rotary granulation, carrying out boiling drying, and finishing granules, so as to obtain the phellinus igniarius compound granules. The preparation method of the phellinus igniarius compound granules has one or more of the following advantages: the prepared product is low in bacterial content, good in safety, high in granulation efficiency, short in drying time, low in water content, high in overall process efficiency, good in product quality stability, uniform in granules, low in raw material loss and convenient for large-scale production.

Description

Technical Field

[0001] The invention relates to a preparation method of mulberry ignia compound granules. Background Art

[0002] Phellinus igniarius compound granules have antioxidant and anti-inflammatory effects, helping to enhance human immunity. Clinical studies have shown that mulberry igniarius compound granules also have certain anti-tumor properties. Existing methods for preparing mulberry igniarius compound granules have the following disadvantages: the resulting product is prone to microbial growth; the soft material produced during the raw material mixing stage is generally viscous and has strong adhesion, making it difficult to thoroughly clean the equipment and causing a high degree of contamination to the next batch of products; the risk factor is high; during the granulation stage, efficiency is low and uniformity is poor, and the soft material leaves a large amount of tailing in the equipment, making disassembly difficult during cleaning and easily causing injuries when cleaning the granulation net. After repeated disassembly of the equipment, the vibration caused by re-operation of the equipment can easily cause the granulation net to shift or fall off; during the drying stage, the drying temperature is generally high, the drying time is long, and the uniformity of the dried material is poor.

[0003] Given the importance of mulberry fungus compound granules, there is an urgent need to develop a preparation method that has a low bacterial content, good safety, high granulation efficiency, short drying time, low water content, high overall process efficiency, good product quality stability, uniform granules, low raw material loss and is easy to produce on a large scale. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the defects of the product prepared by the method for preparing mulberry ignia compound granules in the prior art, such as easy breeding of microorganisms, poor safety, low granulation efficiency, long drying time, high water content, poor product quality stability, and being unfavorable for large-scale production.

[0005] To this end, the present invention provides a method for preparing mulberry ignia compound granules, which has one or more of the following advantages: the prepared product has low bacterial content, good safety, high granulation efficiency, short drying time, low water content, high overall process efficiency, good product quality stability, uniform granules, low raw material loss and is easy for large-scale production.

[0006] The present invention solves the above technical problems through the following technical solutions.

[0007] The present invention provides a method for preparing mulberry linterus compound granules, which comprises the following steps:

[0008] (1) Phellinus igniarius extract, Polygonatum sibiricum extract, Astragalus membranaceus extract, maltodextrin and C 1-6 The alcohols are mixed to obtain a mixture;

[0009] (2) performing rotary granulation on the mixture to obtain a granulated material;

[0010] (3) boiling-drying the granulated material to obtain dry granules; the boiling-drying temperature is 50-90°C;

[0011] (4) The dried granules are granulated to obtain the mulberry ignia compound granules.

[0012] In certain preferred embodiments of the present invention, certain conditions, operations or materials in the preparation method of the Phellinus igniarius compound granules have the following definitions, and the conditions, operations or materials not mentioned are the same as those described in any embodiment of the present invention (referred to as "in a certain embodiment of the present invention").

[0013] In one embodiment of the present invention, the preparation method of the Phellinus igniarius extract comprises the following steps:

[0014] (1) Soften the cleaned Phellinus igniarius raw material by steaming and cutting it into irregular blocks; the diameter of the irregular blocks is preferably 1-3.5 cm;

[0015] (2) Soaking: Soaking the irregular block in water, discarding the supernatant, and obtaining the irregular block wet product A;

[0016] The soaking time is preferably 8-16 h, for example 12 h;

[0017] The mass ratio of the water to the irregular blocks is preferably (4:1)-(12:1), for example 8:1;

[0018] (3) First step: mixing water and irregular lump wet product A, soaking, steam heating, extraction, and filtering to obtain liquid A and irregular lump wet product B;

[0019] In one embodiment, the mass ratio of water to the mass ratio of the irregular blocks in step (1) is preferably (8:1)-(16:1), for example, 12:1;

[0020] The soaking time is preferably 10-60 min, preferably 20-40 min, for example 30 min;

[0021] The temperature of the steam heating is preferably 80-120°C, preferably 100-110°C, for example 105°C;

[0022] The steam heating pressure is preferably 0.2-0.4 Mpa, for example 0.3 Mpa;

[0023] The extraction time is preferably 100-400 min, preferably 200-300 min, for example 240 min;

[0024] The filtration is preferably performed using gauze filtration, for example, using 300 mesh gauze filtration;

[0025] (4) Second extraction: Mix water and irregular block wet product B, steam heat, extract, and filter to obtain liquid B;

[0026] In the second extraction, the mass ratio of water to the mass of the irregular blocks in step (1) is preferably (8:1)-(16:1), for example, 12:1;

[0027] The temperature of the steam heating is preferably 80-120°C, preferably 100-110°C, for example 105°C;

[0028] The steam heating pressure is preferably 0.2-0.4 Mpa, for example 0.3 Mpa;

[0029] The extraction time is preferably 100-300 min, preferably 150-250 min, for example 180 min;

[0030] The filtration is preferably performed using gauze filtration, for example, using 300 mesh gauze filtration;

[0031] (5) Combine liquid A and liquid B and concentrate to obtain a concentrated solution;

[0032] The concentration is preferably carried out at 80-90°C, for example, at 85°C;

[0033] The concentration is preferably carried out in a concentration tank;

[0034] The density of the concentrate is 1.15-1.2 g / mL, for example 1.2 g / mL;

[0035] (6) Drying the concentrated liquid to obtain a block;

[0036] The drying is preferably drying under reduced pressure;

[0037] The reduced pressure drying is preferably carried out in a reduced pressure drying oven, more preferably in a reduced pressure drying oven at 70-200°C (e.g., 85°C) and (-0.05 MPa)-(-0.2 MPa) (e.g., -0.09 MPa) for 14-42 h (e.g., 28 h);

[0038] The moisture content of the block is preferably ≤10%, more preferably ≤5%;

[0039] (7) crushing the block and sieving to obtain the Phellinus igniarius extract;

[0040] The sieving is preferably performed using an 80-mesh sieve;

[0041] Preferably, the preparation method of the Phellinus igniarius extract is carried out through the above steps (ie, without other steps).

[0042] In one embodiment of the present invention, the method for preparing the polygonatum extract comprises the following steps:

[0043] (1) Soften the cleaned raw material of Polygonatum odoratum by steaming and cutting it into irregular blocks; the diameter of the irregular blocks is preferably 1-3.5 cm;

[0044] (2) Soaking: Soaking the irregular block in water, discarding the supernatant, and obtaining the irregular block wet product A;

[0045] The soaking time is preferably 8-16 h, for example 12 h;

[0046] The mass ratio of the water to the irregular blocks is preferably (4:1)-(12:1), for example 8:1;

[0047] (3) First step: mixing water and irregular lump wet product A, soaking, steam heating, extraction, and filtering to obtain liquid A and irregular lump wet product B;

[0048] In one embodiment, the mass ratio of water to the mass ratio of the irregular blocks in step (1) is preferably (8:1)-(16:1), for example, 12:1;

[0049] The soaking time is preferably 10-60 min, preferably 20-40 min, for example 30 min;

[0050] The temperature of the steam heating is preferably 80-120°C, preferably 100-110°C, for example 105°C;

[0051] The steam heating pressure is preferably 0.2-0.4 Mpa, for example 0.3 Mpa;

[0052] The extraction time is preferably 100-400 min, preferably 200-300 min, for example 240 min;

[0053] The filtration is preferably performed using gauze filtration, for example, using 300 mesh gauze filtration;

[0054] (4) Second extraction: Mix water and irregular block wet product B, steam heat, extract, and filter to obtain liquid B;

[0055] In the second extraction, the mass ratio of water to the mass of the irregular blocks in step (1) is preferably (8:1)-(16:1), for example, 12:1;

[0056] The temperature of the steam heating is preferably 80-120°C, preferably 100-110°C, for example 105°C;

[0057] The steam heating pressure is preferably 0.2-0.4 Mpa, for example 0.3 Mpa;

[0058] The extraction time is preferably 100-300 min, preferably 150-250 min, for example 180 min;

[0059] The filtration is preferably performed using gauze filtration, for example, using 300 mesh gauze filtration;

[0060] (5) Combine liquid A and liquid B and concentrate to obtain a concentrated solution;

[0061] The concentration is preferably carried out at 80-90°C, for example, at 85°C;

[0062] The concentration is preferably carried out in a concentration tank;

[0063] The density of the concentrate is 1.15-1.2 g / mL, for example 1.2 g / mL;

[0064] (6) Drying the concentrated liquid to obtain a block;

[0065] The drying is preferably drying under reduced pressure;

[0066] The reduced pressure drying is preferably carried out in a reduced pressure drying oven, more preferably in a reduced pressure drying oven at 70-200°C (e.g., 85°C) and (-0.05 MPa)-(-0.2 MPa) (e.g., -0.09 MPa) for 14-42 h (e.g., 28 h);

[0067] The moisture content of the block is preferably ≤10%, more preferably ≤5%;

[0068] (7) crushing the block and sieving to obtain a polygonatum extract;

[0069] The sieving is preferably performed using an 80-mesh sieve;

[0070] Preferably, the preparation method of the Polygonatum sibiricum extract is carried out through the above steps.

[0071] In one embodiment of the present invention, the method for preparing the astragalus extract comprises the following steps:

[0072] (1) Soften the cleaned Astragalus membranaceus raw material by steaming and cutting it into irregular blocks; the diameter of the irregular blocks is preferably 1-3.5 cm;

[0073] (2) Soaking: Soaking the irregular block in water, discarding the supernatant, and obtaining the irregular block wet product A;

[0074] The soaking time is preferably 8-16 h, for example 12 h;

[0075] The mass ratio of the water to the irregular blocks is preferably (4:1)-(12:1), for example 8:1;

[0076] (3) First step: mixing water and irregular lump wet product A, soaking, steam heating, extraction, and filtering to obtain liquid A and irregular lump wet product B;

[0077] In one embodiment, the mass ratio of water to the mass ratio of the irregular blocks in step (1) is preferably (8:1)-(16:1), for example, 12:1;

[0078] The soaking time is preferably 10-60 min, preferably 20-40 min, for example 30 min;

[0079] The temperature of the steam heating is preferably 80-120°C, preferably 100-110°C, for example 105°C;

[0080] The steam heating pressure is preferably 0.2-0.4 Mpa, for example 0.3 Mpa;

[0081] The extraction time is preferably 100-400 min, preferably 200-300 min, for example 240 min;

[0082] The filtration is preferably performed using gauze filtration, for example, using 300 mesh gauze filtration;

[0083] (4) Second extraction: Mix water and irregular block wet product B, steam heat, extract, and filter to obtain liquid B;

[0084] In the second extraction, the mass ratio of water to the mass of the irregular blocks in step (1) is preferably (8:1)-(16:1), for example, 12:1;

[0085] The temperature of the steam heating is preferably 80-120°C, preferably 100-110°C, for example 105°C;

[0086] The steam heating pressure is preferably 0.2-0.4 Mpa, for example 0.3 Mpa;

[0087] The extraction time is preferably 100-300 min, preferably 150-250 min, for example 180 min;

[0088] The filtration is preferably performed using gauze filtration, for example, using 300 mesh gauze filtration;

[0089] (5) Combine liquid A and liquid B and concentrate to obtain a concentrated solution;

[0090] The concentration is preferably carried out at 80-90°C, for example, at 85°C;

[0091] The concentration is preferably carried out in a concentration tank;

[0092] The density of the concentrate is 1.15-1.2 g / mL, for example 1.2 g / mL;

[0093] (6) Drying the concentrated liquid to obtain a block;

[0094] The drying is preferably drying under reduced pressure;

[0095] The reduced pressure drying is preferably carried out in a reduced pressure drying oven, more preferably in a reduced pressure drying oven at 70-200°C (e.g., 85°C) and (-0.05 MPa)-(-0.2 MPa) (e.g., -0.09 MPa) for 14-42 h (e.g., 28 h);

[0096] The moisture content of the block is preferably ≤10%, more preferably ≤5%;

[0097] (7) crushing the block and sieving to obtain the astragalus extract;

[0098] The sieving is preferably performed using an 80-mesh sieve;

[0099] Preferably, the preparation method of the astragalus extract is carried out through the above steps.

[0100] In one embodiment of the present invention, in step (1), the C 1-6 The alcohol is preferably C 1-3 Alcohol, such as ethanol; the ethanol is preferably 95% ethanol.

[0101] In one embodiment of the present invention, in step (1), the C 1-6 Alcohol is a binder.

[0102] In one embodiment of the present invention, in step (1), the mass ratio of the Phellinus igniarius extract to the Polygonatum sibiricum extract is (1-2):1, for example, 1.5:1.

[0103] In one embodiment of the present invention, in step (1), the mass ratio of the Phellinus igniarius extract to the Astragalus membranaceus extract is (1-2):1, for example, 1.5:1.

[0104] In one embodiment of the present invention, in step (1), the mass ratio of the Phellinus igniarius extract to the maltodextrin is (0.5-1.5):1, for example, 1:1.

[0105] In one embodiment of the present invention, in step (1), the mass ratio of the Phellinus igniarius extract, Polygonatum sibiricum extract, Astragalus membranaceus extract and maltodextrin is 3:2:2:3.

[0106] In one embodiment of the present invention, in step (1), the C 1-6 The ratio of the mass of alcohol to the total mass of the Phellinus igniarius extract, the Polygonatum sibiricum extract, the Astragalus membranaceus extract and the maltodextrin is (0.30-0.60):1, for example, 0.45:1.

[0107] In one embodiment of the present invention, in step (1), the “mixing” is mixing in a mixer, preferably mixing in a mixer for 20-40 min, for example, mixing in a mixer for 30 min.

[0108] In one embodiment of the present invention, in step (2), the rotary granulation is preferably performed using a ZL-300 rotary granulator.

[0109] In one embodiment of the present invention, in step (2), the rotary granulation is performed until particles are visually visible;

[0110] Preferably, the rotary granulation time is 2-7 min, such as 5 min.

[0111] In one embodiment of the present invention, in step (3), the boiling drying temperature is 70°C.

[0112] In one embodiment of the present invention, in step (3), the boiling drying time is 5-10 minutes.

[0113] In one embodiment of the present invention, in step (3), the boiling drying is performed using a GFG high-efficiency boiling dryer.

[0114] In one embodiment of the present invention, in step (3), the moisture content of the dried particles is ≤10%, preferably ≤7%.

[0115] In one embodiment of the present invention, in step (4), the granulation is performed using a YK-160 swing granulator.

[0116] In one embodiment of the present invention, in step (4), the granulation is performed under 8-16 mesh conditions, for example, under 12 mesh conditions.

[0117] In one embodiment of the present invention, in step (4), after the granulation step, the steps of sealing, weighing, inner packaging and boxing are also included;

[0118] The inner packaging is preferably configured to package a single package with a net content of 2.85g-3.15g, for example, 3g;

[0119] The boxing is preferably carried out by packing a single box into 30 packages / box.

[0120] In a certain embodiment of the present invention, the Phellinus igniarius compound granules are prepared by the following steps (i.e., without other steps):

[0121] (1) The phellinus igniarius extract, the polygonatum sibiricum extract, the astragalus root extract and maltodextrin were placed in a mixer at a ratio of 30%:20%:20%:30% (mass ratio), and 45% (the mass of ethanol, compared to the total mass of the aforementioned medicinal materials and maltodextrin, the ratio is 45%) of 95% ethanol was added as a binder and uniformly mixed for 30 minutes to obtain a mixture;

[0122] (2) placing the mixture into a ZL-300 rotary granulator for rotary granulation (as long as granules are visually observed) to obtain granules;

[0123] (3) The granulated material is placed in a drying oven at 70°C for boiling drying to obtain dry granules (using a GFG high-efficiency boiling dryer); the boiling drying time is 5-10 minutes; the moisture content of the dry granules is ≤7%;

[0124] (4) The dried granules were placed in a granulator (using a YK-160 swing granulator, 12 mesh), sealed, and weighed;

[0125] (5) The granulated material is loaded into the machine hopper through a vacuum pump for automatic inner packaging. The net content of each package is 3g, with an allowable deviation of ±5% (2.85g-3.15g);

[0126] (6) The inner packages are packed into boxes at a specification of 30 packages per box to obtain the Phellinus Immaturus Compound Granules.

[0127] In one embodiment of the present invention, the relevant information of the medicinal material is as follows:

[0128] Phellinus igniarius: This product is the dried fruiting body of the fungus Sanghuangporus vaninii (Ljub) LWZhou et YCDai, a member of the family Pseudomonas. Depending on the culture medium, it is divided into "stubular mulberry" and "bag-grown mulberry." The fruiting bodies are harvested when mature, impurities removed, and then oven-dried at low temperature or sun-dried. Whole fruiting bodies are commonly known as "mulberry ignia individual"; fresh fruiting bodies are cut into thick slices and dried, commonly known as "mulberry ignia slices"; fresh fruiting bodies are cut into cubes and dried, commonly known as "mulberry ignia blocks."

[0129] Polygonatum sibiricum: The dried rhizome of Polygonatum kingianum Coll.et Hemsl, Polygonatum sibiricum Red, or Polygonatum cyrtonema Hua, all of the Liliaceae family. Depending on its shape, it is commonly known as "big polygonatum," "chicken-headed polygonatum," or "ginger-shaped polygonatum." Harvest in spring and autumn, remove the fibrous roots, wash, and briefly blanch in boiling water or steam until thoroughly cooked through, then dry.

[0130] Astragalus: The dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge., both of the Leguminosae family. Harvested in spring and autumn, the fibrous roots and root tips removed, and sun-dried.

[0131] Without violating the common sense in the art, the above-mentioned preferred conditions can be arbitrarily combined to obtain preferred embodiments of the present invention.

[0132] The reagents and raw materials used in the present invention are commercially available.

[0133] The positive progress effect of the present invention is:

[0134] (1) The method for preparing the mulberry linterus compound granules provided by the present invention has one or more of the following advantages: the prepared product has low bacterial content, good safety, high granulation efficiency, short drying time, low water content, high overall process efficiency, good product quality stability, uniform granules, low raw material loss, and is convenient for large-scale production;

[0135] (2) In the mixing process, ethanol is used as a binder for wet mixing. This process effectively reduces product loss and ensures that the product is processed under effective sterilization conditions. The use of ethanol significantly reduces the generation of potentially harmful substances in food and improves product safety. At the same time, this method achieves rapid and uniform dispersion, ensuring the uniformity of each component during the mixing process, thereby improving the consistency and stability of the product.

[0136] (3) The rotary granulation method is used in the granulation process, which has better uniformity and continuity compared to the common swing granulation method on the market. This innovation not only shortens the granulation time and improves the granulation efficiency, but also significantly improves the granulation effect, ensuring that each granule is uniform, thereby improving the overall quality of the product.

[0137] (4) The use of boiling drying method significantly improved production capacity and greatly shortened drying time. The process was carried out under the environmental conditions of 70 ° C. The material was heated evenly, the drying time was short, the moisture content of the product was lower, and the particles were uniform after drying. It effectively ensured that the nutrients in the product were not destroyed or decomposed, thereby maintaining the quality stability of the mulberry fungus compound granules. This innovation ensured the efficiency and safety of the product in large-scale production. DETAILED DESCRIPTION

[0138] The present invention is further illustrated by way of examples below, but the invention is not limited to the scope of the examples. Experimental methods in the following examples where specific conditions are not specified were performed according to conventional methods and conditions, or selected according to the product specifications. All reagents used in this application were commercially available and used without further purification.

[0139] The relevant information of the Chinese medicinal materials involved in the present invention is as follows:

[0140] Phellinus igniarius: This product is the dried fruiting body of the fungus Sanghuangporus vaninii (Ljub) LWZhou et YCDai, a member of the family Pseudomonas. Depending on the culture medium, it is divided into "stubular mulberry" and "bag-grown mulberry." The fruiting bodies are harvested when mature, freed of impurities, and then oven-dried at low temperature or sun-dried. Whole fruiting bodies are commonly known as "mulberry ignia individual"; fresh fruiting bodies cut into thick slices and dried are commonly known as "mulberry ignia slices"; fresh fruiting bodies cut into cubes and dried are commonly known as "mulberry ignia blocks."

[0141] Polygonatum sibiricum: The dried rhizome of Polygonatum kingianum Coll. et Hemsl, Polygonatum sibiricum Red., or Polygonatum cyrtonema Hua, all from the Liliaceae family. Depending on their shape, they are commonly known as "big polygonatum," "chicken-headed polygonatum," or "ginger-shaped polygonatum." Harvest in spring and autumn, remove the fibrous roots, wash, briefly blanch in boiling water or steam until thoroughly cooked, and then dry.

[0142] Astragalus: The dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge., both of the Leguminosae family. Harvested in spring and autumn, the fibrous roots and root tips removed, and sun-dried.

[0143] Example 1 Preparation of extract

[0144] Preparation of Phellinus igniarius extract

[0145] The Phellinus linteus raw material was cleaned to remove surface dust and impurities, softened using a steaming method, and then cut using a fully automatic cutting machine into irregular blocks with a diameter of approximately 1-3.5 cm. The cut Phellinus linteus raw material was then soaked in water (Pellinus linteus raw material: water = 1:8, mass ratio) for 12 hours. The supernatant was discarded, and the soaked wet Phellinus linteus raw material was placed in an extraction tank. Water was further added (material-liquid ratio of 1:12, so that the water surface covered the raw material; the material-liquid ratio is the mass of the initial dry material of Phellinus linteus raw material to the mass of the added water). After soaking for 30 minutes, the raw material was steam-heated to 105°C, pressure of 0.3 MPa, and extracted for 240 minutes. After the first extraction, the raw material was filtered through 300-mesh gauze, the liquid was discharged, and water was further added (material-liquid ratio of 1:12, so that the water surface covered the raw material; the material-liquid ratio is the mass of the initial dry material of Phellinus linteus raw material to the mass of the added water). Steam-heated to 105°C, pressure of 0.3 MPa, and extracted for 180 minutes. After the second extraction, the liquid was filtered through 300-mesh gauze and released. The combined liquids from the first and second extractions were concentrated in an 85°C concentrator to a density of 1.2 g / mL. The extract was then dried in a vacuum oven at 85°C, -0.09 MPa, for 28 hours to a moisture content of ≤5%. The dried extract was crushed and sieved through an 80-mesh sieve to obtain the Phellinus igniarius extract.

[0146] The polygonatum sibiricum extract and the astragalus root extract are prepared by the same method as the phellinus igniarius extract, with the only difference being the raw materials.

[0147] Example 2 Preparation of Phellinus Immaturus Compound Granules

[0148] (1) The aforementioned Phellinus igniarius extract, Polygonatum sibiricum extract, Astragalus membranaceus extract and maltodextrin were placed in a mixer at a ratio of 30%:20%:20%:30% (mass ratio), and 45% (the mass of ethanol, compared to the total mass of the aforementioned medicinal materials and maltodextrin, the ratio is 45%) of 95% ethanol was added as a binder and mixed evenly for 30 minutes;

[0149] (2) Place the mixture into a ZL-300 rotary granulator for rotary granulation (visually observe the presence of granules, about 5 minutes);

[0150] (3) The granulated material was placed in a drying oven at 70°C for boiling drying (using a GFG high-efficiency boiling dryer); the boiling drying time was 5-10 minutes;

[0151] (4) Place the dried and qualified granules (moisture ≤ 7%) into the granulator (using YK-160 swing granulator, 12 mesh), seal, and weigh;

[0152] (5) The granulated material is loaded into the machine hopper through a vacuum pump for automatic inner packaging. The net content of each package is 3g, with an allowable deviation of ±5% (2.85g-3.15g);

[0153] (6) The inner packages are packed into boxes at a specification of 30 packages per box to obtain the Phellinus Immaturus Compound Granules.

[0154] Comparative Example 1 Preparation of Phellinus Immaturus Compound Granules Using Traditional Process

[0155] (1) The aforementioned Phellinus igniarius extract, Polygonatum sibiricum extract, Astragalus membranaceus extract and maltodextrin (CAS: 9050-36-6) were placed in a mixer at a ratio of 30%:20%:20%:30% (mass ratio), and 45% (the mass of water, compared to the total mass of the aforementioned medicinal materials and maltodextrin, the ratio is 45%) of water was added as a binder and mixed evenly for 30 minutes;

[0156] (2) Shake the mixture to granulate (visually observe the presence of granules, about 15 minutes);

[0157] (3) The granulated material was dried in a hot air circulation drying oven (70°C); the hot air circulation drying time was about 180 minutes;

[0158] (4) Place the dried and qualified granules (moisture ≤ 7%) into the granulator (using YK-160 swing granulator, 12 mesh), seal, and weigh;

[0159] (5) The granulated material is loaded into the machine hopper through a vacuum pump for automatic inner packaging. The net content of each package is 3g, with an allowable deviation of ±5% (2.85g-3.15g);

[0160] (6) The inner packages are packed into boxes at a specification of 30 packages per box to obtain the Phellinus Immaturus Compound Granules.

[0161] Effect Example 1 Detection of Phellinus igniarius compound granules prepared by different methods

[0162] The parameters of the Phellinus Immaturus Compound Granules prepared by the methods of Example 2 and Comparative Example 1 were tested respectively, and the results were as follows:

[0163]

[0164] As shown in Table 1, the use of ethanol as a binder in the wet mixing process effectively reduces product loss while ensuring effective sterilization. The use of ethanol significantly reduces the formation of potentially harmful substances in food, improving product safety. Furthermore, this method achieves rapid and uniform dispersion, ensuring uniformity of all ingredients during mixing, thereby improving product consistency and stability.

[0165]

[0166] As shown in Table 2, the rotary granulation method used in the granulation process offers superior uniformity and continuity compared to the commonly used swing granulation method. This innovation not only shortens granulation time and increases efficiency, but also significantly improves the granulation effect, ensuring that each granule is uniform and consistent, thereby enhancing the overall quality of the product.

[0167]

[0168] As shown in Table 3, the fluidized bed drying method significantly increases production capacity and greatly shortens drying time. This process, performed at 70°C, heats the material evenly, shortens drying time, and reduces moisture content. The dried material forms uniform particles, effectively preventing the destruction or degradation of nutrients in the product and maintaining the quality stability of the Phellinus Immaturus Compound Granules. This innovation ensures the product's efficiency and safety in large-scale production.

Claims

1. A method for preparing Phellinus igniarius compound granules, comprising the following steps: (1) Phellinus igniarius extract, Polygonatum sibiricum extract, Astragalus membranaceus extract, maltodextrin and C 1-6 The alcohols are mixed to obtain a mixture; (2) performing rotary granulation on the mixture to obtain a granulated material; (3) boiling-drying the granulated material to obtain dry granules; the boiling-drying temperature is 50-90°C; (4) The dried granules are granulated to obtain the mulberry ignia compound granules.

2. The method for preparing the Phellinus igniarius compound granules according to claim 1, wherein: It meets one or more of the following conditions: (1) In step (1), the C 1-6 Alcohol is C 1-3 alcohol; (2) In step (1), the mass ratio of the Phellinus igniarius extract to the Polygonatum sibiricum extract is (1-2):1; (3) In step (1), the mass ratio of the Phellinus igniarius extract to the Astragalus membranaceus extract is (1-2):1; (4) In step (1), the mass ratio of the Phellinus igniarius extract to the maltodextrin is (0.5-1.5):1; (5) In step (1), the C 1-6 The ratio of the mass of the alcohol to the total mass of the Phellinus linteus extract, the Polygonatum sibiricum extract, the Astragalus membranaceus extract and the maltodextrin is (0.30-0.60): 1; (6) In step (1), the "mixing" refers to mixing in a mixer; (7) In step (1), the C 1-6 Alcohol is a binder.

3. The method for preparing the Phellinus igniarius compound granules according to claim 2, wherein: It meets one or more of the following conditions: (1) In step (1), the C 1-3 Alcohol is ethanol; (2) In step (1), the mass ratio of the Phellinus igniarius extract to the Polygonatum sibiricum extract is 1.5:1; (3) In step (1), the mass ratio of the Phellinus igniarius extract to the Astragalus membranaceus extract is 1.5:1; (4) In step (1), the mass ratio of the Phellinus igniarius extract to the maltodextrin is 1:1; (5) In step (1), the C 1-6 The ratio of the mass of the alcohol to the total mass of the Phellinus linteus extract, the Polygonatum sibiricum extract, the Astragalus membranaceus extract and the maltodextrin is 0.45:1; (6) In step (1), the "mixing" is mixing in a mixer for 20-40 min.

4. The method for preparing the Phellinus igniarius compound granules according to claim 3, wherein: It meets one or more of the following conditions: (1) In step (1), the ethanol is 95% ethanol; (2) In step (1), the mass ratio of the Phellinus igniarius extract, Polygonatum sibiricum extract, Astragalus membranaceus extract and maltodextrin is 3:2:2:3; (3) In step (1), the "mixing" is mixing in a mixer for 30 min.

5. The method for preparing the Phellinus igniarius compound granules according to claim 1, wherein: It meets one or both of the following conditions: (1) In step (2), the rotary granulation is performed using a ZL-300 rotary granulator; (2) In step (2), the rotary granulation is performed until particles are visually visible.

6. The method for preparing the Phellinus igniarius compound granules according to claim 5, wherein: In step (2), the rotary granulation time is 2-7 min.

7. The method for preparing the Phellinus igniarius compound granules according to claim 6, wherein: In step (2), the rotary granulation time is 5 min.

8. The method for preparing the Phellinus igniarius compound granules according to claim 1, wherein: It meets one or more of the following conditions: (1) In step (3), the boiling drying temperature is 70°C; (2) In step (3), the boiling drying time is 5-10 min; (3) In step (3), the boiling drying is carried out using a GFG high-efficiency boiling dryer; (4) In step (3), the moisture content of the dried particles is ≤10%; (5) In step (4), the granulation is performed using a YK-160 swing granulator; (6) In step (4), the granulation is carried out under the condition of 8-16 mesh; (7) In step (4), after the granulation step, the steps of sealing, weighing, inner packaging and boxing are also included.

9. The method for preparing the Phellinus igniarius compound granules according to claim 8, wherein: It meets one or more of the following conditions: (1) In step (3), the moisture content of the dried particles is ≤7%; (2) In step (4), the granulation is carried out under the condition of 12 mesh; (3) In step (4), after the granulation step, the steps of sealing, weighing, inner packaging and boxing are also included; the inner packaging is to pack a single package with a net content of 2.85g-3.15g; the boxing is to pack a single box into 30 packages / box.

10. The method for preparing the Phellinus igniarius compound granules according to claim 1, wherein: The Phellinus igniarius compound granules are prepared by the following steps: (1) The phellinus linteus extract, the polygonatum sibiricum extract, the astragalus root extract and maltodextrin were placed in a mixer at a ratio of 30%:20%:20%:30%, and 45% of 95% ethanol was added as a binder and uniformly mixed for 30 minutes to obtain a mixture; (2) placing the mixture into a ZL-300 rotary granulator and performing rotary granulation until particles are visible to the naked eye, thereby obtaining a granulated material; (3) placing the granulated material in a dryer at 70° C. for boiling drying to obtain dry granules; the boiling drying time is 5-10 min; the dryer is a GFG high-efficiency boiling dryer; the moisture content of the dry granules is ≤7%; (4) placing the dried granules into a granulator for granulation, sealing, and weighing; the granulator is a YK-160 swing granulator; (5) The granulated material is loaded into the machine hopper through a vacuum pump for automatic inner packaging. The net content of each package is 3g, and the allowable deviation is ±5%; (6) The inner packages are packed into boxes at a specification of 30 packages per box to obtain the Phellinus Immaturus Compound Granules.

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