Angelica keiskei peptide hypoglycemic pill with hypoglycemic activity

Abstract

A antler peptide hypoglycemic pill with hypoglycemic activity belongs to the technical field of Chinese patent medicine production, all the raw materials need to be processed into powder, all the powdery raw materials are crushed into fine powder with the particle size of 200 meshes by a crusher, and the powdery raw materials are prepared from 50% of peptide-enriched tenebrio molitor powder, 25% of selenium-enriched wheat leaf powder, 2% of ginseng powder, 6% of corn stigma powder, 5% of corn stigma powder, 5% of corn stigma powder and 5% of corn stigma powder. The peptide-enriched tenebrio molitor powder is prepared from, by weight, 3% of fructus schizandrae powder, 10% of inonotuso bliquus (Fr) Pilat powder and 4% of radix polygonati officinalis powder. Before the selenium-rich wheat leaf powder is used, the selenium content is detected in advance, and after the selenium content in the selenium-rich wheat leaf powder is detected, the selenium-rich wheat leaf powder can be used only when the selenium content exceeds 40 micrograms per kilogram; the ginseng powder is powder prepared from commercially available ginseng, and the ginseng must be ginseng growing for 8 years or more than 8 years. The invention has the advantages of simple manufacture, convenient use, low cost and obvious effect.

Description

Technical Field

[0001] The invention relates to Rongpeptide hypoglycemic pills having blood sugar lowering activity, belonging to the technical field of Chinese patent medicine preparation. Background Art

[0002] Diabetes, known as "xiaoke disease" in Traditional Chinese Medicine, is a chronic systemic metabolic disease caused by a combination of genetic and environmental factors. The current global picture of diabetes is as follows: First, the number of people suffering from the disease is increasing: the number of people with diabetes worldwide has surged from approximately 200 million in 1990 to 828 million in 2022. Prevalence is also rising: in 2022, the global diabetes prevalence among adults aged 18 and over was 14%, a significant increase from 7% in 1990. Secondly, the situation varies across regions: High-income countries have relatively stable prevalence rates, but the absolute number of patients is still increasing due to factors such as aging populations. Low- and middle-income countries have seen rapid increases in prevalence rates, making them the primary regions for the increase in diabetes cases. Finally, there are the mortality and complications of diabetes. Some cases result in direct death: in 2021, diabetes directly caused 1.6 million deaths, with an additional 47% of diabetes-related deaths occurring in people under 70 years of age. Other cases result in death from complications: diabetes and diabetic kidney disease caused over 2 million deaths in 2021, and hyperglycemia also accounted for approximately 11% of cardiovascular deaths. Finally, regarding the incidence trends of diabetes, there are two key factors: 1. It will continue to rise: the global diabetes prevalence is projected to rise from 6.28% in 2021 to 7.079‰ by 2030, a bleak outlook. 2. It is also affecting younger people: the incidence of diabetes is increasing not only among the elderly but also among young people and even children, a phenomenon closely linked to unhealthy lifestyles. Diabetes has a certain genetic predisposition. For example, among patients with type 1 diabetes, the risk of first-degree relatives (parents, siblings) developing the disease is 3-40 times higher than in the general population. Type 2 diabetes has a stronger familial clustering: if both parents have type 2 diabetes, the risk for their children can be as high as 50%. Environmental factors primarily include an unhealthy lifestyle, such as a long-term high-calorie diet and lack of exercise. These factors can lead to energy intake exceeding energy expenditure, leading to obesity, increased insulin resistance, and the development of diabetes. Furthermore, negative psychological factors such as chronic stress, excessive stress, and lack of sleep are also associated with the development of diabetes. Typical symptoms include increased drinking, urination, and food intake, as well as weight loss—the "three excesses and one deficiency" symptom. The patient's blood sugar rises, which leads to increased blood osmotic pressure, stimulating the thirst center and causing polydipsia. At the same time, a large amount of sugar is excreted in the urine, taking away a large amount of water, causing polyuria. Since the body cannot fully utilize glucose, the patient will feel hungry and eat more. However, due to the accelerated decomposition of fat and protein in the body, weight will decrease instead. Some patients have atypical symptoms: especially in the early stages of diabetes or type 2 diabetes, they may only show fatigue, itchy skin, slow wound healing, blurred vision, etc. Diagnostic blood sugar test: It is the main basis for diagnosing diabetes. Fasting blood sugar ≥7.0mmol / L, or blood sugar ≥11.1mmol / L 2 hours after a meal, or random blood sugar ≥11.1mmol / L accompanied by typical symptoms can be diagnosed as diabetes.Other tests, such as glycated hemoglobin (HbA1c), reflect average blood sugar levels over the past two to three months. An HbA1c ≥ 6.5% is also used to diagnose diabetes. Many people are diligently striving to treat and manage diabetes. Common methods and approaches for lowering blood sugar include the following: Lifestyle interventions and dietary control: This is the foundational approach to lowering blood sugar. A balanced diet is essential, controlling total calorie intake and ensuring a balanced diet. Increasing dietary fiber, such as vegetables and whole grains, can help slow blood sugar spikes. Reducing intake of foods high in sugar, fat, and salt, and avoiding sugary foods such as candy, pastries, and beverages, as well as high-fat foods such as fried or pan-fried foods, should be avoided. Eating small, frequent meals is recommended, and overeating is recommended. Exercise: Appropriate exercise can increase the body's utilization of glucose, improve insulin sensitivity, and help lower blood sugar. Aerobic exercise, such as brisk walking, jogging, swimming, and cycling, is a good option. Exercise for at least 30 minutes each session, with at least 150 minutes per week. In addition, you can also incorporate strength training, such as weightlifting and push-ups, to increase muscle strength and improve your basal metabolic rate. Exercise safely to avoid hypoglycemia and eat a proper meal before exercise. Weight control: For overweight or obese diabetics, weight loss can improve insulin resistance and lower blood sugar. It is recommended to maintain a body mass index (BMI) between 18.5 and 23.9 kg / m2. 2within the normal range. Gradually lose weight through a reasonable diet and regular exercise, and avoid rapid weight loss to avoid adverse effects on the body. Quit smoking and limit alcohol consumption: Smoking can aggravate insulin resistance, affect blood sugar control, and increase the risk of diabetic complications. Drinking alcohol can make blood sugar difficult to control and may also cause damage to organs such as the liver. Therefore, diabetic patients should quit smoking and limit alcohol consumption. Drug treatment: Oral hypoglycemic drugs Biguanides: such as metformin, lower blood sugar by reducing liver gluconeogenesis and increasing peripheral tissue sensitivity to insulin, and are the first-line medication for type 2 diabetes. Sulfonylureas: such as gliclazide and glimepiride, mainly lower blood sugar by stimulating pancreatic beta cells to secrete insulin, and are suitable for type 2 diabetic patients with a certain degree of pancreatic function. α-Glucosidase inhibitors: such as acarbose, can delay the absorption of carbohydrates in the intestine and lower postprandial blood sugar, and are suitable for patients with elevated postprandial blood sugar. Thiazolidinediones: such as rosiglitazone and pioglitazone, mainly act to increase peripheral tissue sensitivity to insulin and improve insulin resistance. Meglitinides, such as repaglinide and nateglinide, have a similar mechanism of action to sulfonylureas, but with a faster onset and shorter duration of action. They can mimic physiological insulin secretion and are primarily used to control postprandial blood glucose. Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as sitagliptin and saxagliptin, inhibit DPP-4 activity, increasing glucagon-like peptide-1 (GLP-1) levels, promoting insulin secretion, and inhibiting glucagon secretion, thereby lowering blood glucose. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors, such as dapagliflozin and empagliflozin, inhibit the activity of the sodium-glucose cotransporter-2, increasing glucose and sodium excretion and lowering blood glucose. Insulin therapy is indicated for patients with type 1 diabetes, gestational diabetes, acute complications of diabetes, and type 2 diabetes inadequately responding to oral hypoglycemic medications. Numerous types and dosage forms of insulin are available, including short-acting, intermediate-acting, long-acting, and premixed insulins. The dosage can be selected and adjusted based on the patient's condition and blood glucose levels. Insulin is generally administered by subcutaneous injection. Attention should be paid to the rotation of the injection site to avoid local fat atrophy or hyperplasia. Blood glucose monitoring is an important means of controlling blood sugar. By regularly monitoring blood sugar, we can understand the changes in blood sugar and adjust the treatment plan in time. The frequency and time of blood glucose monitoring should be determined according to the patient's condition, treatment plan and blood sugar control goals. In general, fasting blood sugar, blood sugar 2 hours after meals and blood sugar before bed are commonly used monitoring time points. For patients using insulin or oral hypoglycemic drugs, more frequent blood sugar monitoring may be required, such as 3-7 times a day, including before three meals, 2 hours after three meals, before bedtime, and other time points. Other methods to control blood pressure and blood lipids: High blood pressure and high blood lipids will aggravate the condition of diabetes and increase the risk of diabetic complications.Therefore, patients with diabetes should manage both their blood pressure and blood lipid levels, keeping their blood pressure below 130 / 80 mmHg and their low-density lipoprotein cholesterol (LDL-C) below 2.6 mmol / L. Patients with a history of cardiovascular disease should keep their levels below 1.8 mmol / L. Psychological adjustment: Long-term stress, anxiety, depression, and other negative emotions can affect blood sugar control. Patients with diabetes should maintain a positive attitude, learn to regulate their emotions, and avoid excessive stress and anxiety. They can relieve stress by listening to music, traveling, chatting with friends, and seeking help from a psychologist if necessary. Others are actively developing related drugs and methods. For example, CN202411293551.1 provides a plant-based hypoglycemic composition and its preparation method and application; CN202411025416.9 provides a herbal active compound and its preparation method and application; CN202211338119.0 provides a Guangdong Cordyceps hypoglycemic formula for treating type 2 diabetes and its related complications and its preparation method; CN202011455823.5 provides a preparation process for a hypoglycemic drug composition; CN20181115 provides a herbal active compound and its preparation method and application; CN202211338119.0 provides a herbal Cordyceps hypoglycemic formula for treating type 2 diabetes and its related complications; CN202011455823.5 provides a herbal Cordyceps hypoglycemic formula and its preparation method; CN20181115 ...181115 provides a herbal Cordyceps hypoglycemic formula for treating type 2 diabetes and its related complications; CN20181115 provides a herbal Cordyceps hypoglycemic formula and its preparation method; CN20181115 provides a herbal Cordyceps hypoglycemic formula for treating type 2 diabetes and its related complications; CN20181115 provides a herbal Cordyceps hypoglycemic formula and its preparation method; CN20181115 provides a herbal Cordyceps hypoglycemic formula for treating type 2 diabetes and its related complications; CN20181115 6546.0 provides a hypoglycemic pharmaceutical composition containing catalpol, its preparation method and use, CN201811155491.1 provides a sustained-release hypoglycemic pharmaceutical composition, its preparation method and use, CN201811119915.9 provides a bitter melon peptide extraction method and its use, CN201810561855.X provides a hypoglycemic plant extract effective part and its preparation method and use, CN201710423277.9 provides a preparation method of hypoglycemic yellow tea, CN2017104047 74.4 provides a hypoglycemic composition, CN201510445856.4 provides a food, health product or pharmaceutical composition containing wolfberry leaves, CN201510429197.5 provides a hypoglycemic composition containing wolfberry, its use and preparation method, CN201510429198.X provides a hypoglycemic composition containing wolfberry, its use, CN201580081128.8 provides a composition containing coastal pine stem bark extract, papain and aloe extract, and its preparation method, CN20 1310331919.4 provides a hypoglycemic pharmaceutical composition and a preparation method thereof, CN201310199383.5 provides a hypoglycemic pharmaceutical composition and a preparation method thereof, CN201210581798.4 provides a hypoglycemic compound, a preparation method thereof, a pharmaceutical composition containing the same and its use, CN201110459787.4 provides a new use of loofah seeds, CN200810000003.X provides a hypoglycemic pharmaceutical composition, and CN97120257.5 provides a hypoglycemic pharmaceutical composition.However, both drug treatments and other treatments currently have various shortcomings. For example, acarbose is an oral hypoglycemic drug that inhibits α-glucosidase on the small intestinal mucosa, delaying the absorption of carbohydrates in the upper small intestine and reducing the rise in blood sugar after a meal. However, acarbose often causes a number of adverse reactions, such as gastrointestinal reactions: This is the most common adverse reaction, mainly manifested as abdominal distension and increased flatulence. A small number of patients may experience abdominal pain, diarrhea, and constipation. These reactions are usually temporary. As the medication is used for a longer period of time and the body adapts, the symptoms of some patients may be alleviated or disappear. Abnormal liver function: Some patients may experience abnormal liver function, such as elevated transaminases. Therefore, during the use of acarbose, liver function should be monitored regularly, and if abnormalities are found, seek medical attention promptly. Metformin is also a commonly used oral drug for the treatment of diabetes. It mainly lowers blood sugar through multiple pathways: reducing hepatic gluconeogenesis: it can inhibit the production of glucose in the liver and reduce the amount of glucose released into the blood by the liver; increasing the sensitivity of peripheral tissues to insulin: making it easier for peripheral tissues such as muscles to absorb and utilize glucose in the blood, thereby lowering blood sugar; inhibiting intestinal absorption of glucose: in the intestine, metformin can delay the absorption of glucose and reduce the rate at which glucose enters the blood. However, taking metformin often causes some adverse reactions, such as: Gastrointestinal reactions: This is the most common adverse reaction of metformin, including nausea, vomiting, diarrhea, abdominal pain, etc.; generally appear in the early stage of medication, and as the medication time increases, the gastrointestinal reactions of most patients will gradually ease; Vitamin B12 deficiency: Long-term use of metformin may lead to vitamin B12 absorption disorders, thereby causing vitamin B12 deficiency; patients may experience anemia, neuropathy and other symptoms; Lactic acidosis: This is a rare but serious adverse reaction, which mainly occurs in patients with renal insufficiency or severe hypoxia; once lactic acidosis occurs, patients may experience fatigue, drowsiness, difficulty breathing and other symptoms, and need to seek medical attention immediately. Precautions: Patients with renal insufficiency: Metformin should be used with caution in patients with renal insufficiency, as metformin is primarily excreted through the kidneys. Renal insufficiency may cause the drug to accumulate in the body, increasing the risk of lactic acidosis. Before surgery or angiography: Metformin should be temporarily discontinued before invasive examinations or surgery to prevent the contrast agent or surgery from affecting renal function, thereby increasing the risk of lactic acidosis. Alcohol consumption: Alcohol may increase the risk of metformin-induced lactic acidosis, so alcohol consumption should be avoided during metformin use. Therefore, the technical challenge is to develop a pharmaceutical product that can rapidly lower blood sugar levels while ensuring that it does not significantly affect the body, allowing diabetic patients to lower their blood sugar levels without affecting their body functions. Therefore, it is necessary to utilize the combined regulatory effects of active substances such as bioactive peptides, organic selenium, ginseng, and polysaccharides to achieve the goal of safely and effectively lowering blood sugar. The invention of Rongpeptide Jiangtang Pills with blood sugar-lowering activity is necessary. Summary of the Invention

[0003] In order to overcome the technical difficulty of developing a pharmaceutical product that can quickly lower blood sugar levels while ensuring that it does not cause significant effects on the body, so that diabetic patients can lower their blood sugar levels without affecting their body functions, the present invention provides Rongpeptide Hypoglycemic Pills with blood sugar lowering activity. The Rongpeptide Hypoglycemic Pills with blood sugar lowering activity utilize a variety of specially treated material powders that are active in lowering blood sugar, with the help of the repair function of active peptides and the antioxidant function of organic selenium, and then mix them evenly and make honey pills with refined honey, thereby achieving the purpose of lowering blood sugar levels after taking them.

[0004] The technical solution adopted by the present invention to solve its technical problem is:

[0005] The invention discloses a peptide-lowering sugar pill having blood sugar lowering activity. All raw materials used in the pill need to be processed into powder, and all the powdered raw materials are crushed into fine powder with a particle size of 200 meshes by a grinder. The powdered raw materials are characterized in that: the powdered raw materials are composed of 50% peptide-rich mealworm powder, 25% selenium-rich wheat leaf powder, 2% ginseng powder, 6% corn silk powder, 3% schisandra powder, 10% birch mushroom powder, and 4% polygonatum powder. The peptide-rich mealworm powder is made from the seventh or eighth-instar mature larvae of the mealworm; the selenium-rich wheat leaf powder is a commercially available foliar fertilizer that has been tested multiple times to be effective in selenium enrichment. When the winter wheat seedlings grow to about 10 cm, the wheat leaves are sprayed on the leaves. After being treated for 20-30 days, the wheat leaves are harvested. After the wheat leaves are harvested, they are first cleaned and then placed. Dry in the sun or drain and then dry directly. When the moisture content of the wheat leaves drops to 10% or below, first use an agricultural grinder to crush the wheat leaves. At this time, the wheat leaves are not too broken, generally around 10 meshes. Then use a high-power grinder that can grind and crush the material into ultrafine powder to crush the previously broken wheat leaves. The obtained wheat leaf powder must be guaranteed to be around 200 meshes, thereby making the selenium-rich wheat leaf powder required for the Rongpeptide Hypoglycemic Pills. The selenium content of the selenium-rich wheat leaf powder must be tested in advance before use. The selenium content in the selenium-rich wheat leaf powder must be more than 40 micrograms / kg after testing before it can be used. Ginseng powder is a powder made from commercially available ginseng. The ginseng used must be ginseng that has grown for 8 years or more. When processing ginseng powder, fresh ginseng must be used. During processing, the fresh ginseng is first crushed with a grinder. The ginseng is broken into small pieces of about 10 mesh, and then the small ginseng pieces are dried. After that, a high-power grinder that can grind and crush materials into ultrafine powder is used to grind the dried ginseng small pieces into about 200 mesh, thereby making the ginseng powder required for the Rongpeptide Hypoglycemic Pills; corn silk powder is directly collected from the surface of the kernels when the corn is harvested and broken into cobs. Before powdering, the corn silk needs to be cleaned first, and then dried to a moisture content of 20-30%, and then chopped with a guillotine to a length of 1-2 cm. Then, the chopped corn silk is further dried to a moisture content of less than 10%, and a high-power grinder that can grind and crush materials into ultrafine powder is used to grind the dried chopped corn silk into about 200 mesh, thereby making the corn silk required for the Rongpeptide Hypoglycemic Pills. Powder; Schisandra chinensis powder is prepared by first cleaning the harvested Schisandra chinensis fruits, then drying them in the sun until the moisture content is 20-30%, breaking the Schisandra chinensis fruits into small pieces with a pulper, then further drying the Schisandra chinensis fruit pieces until the moisture content is less than 10%, and then using a high-power grinder capable of grinding and crushing materials into ultrafine powder to grind the dried Schisandra chinensis fruit pieces to about 200 mesh, thereby producing the Schisandra chinensis powder required for Rongpeptide Jiangtang Pills; Chaga powder is prepared by first cleaning the harvested Chaga mushrooms, then drying the surface moisture, and breaking the Chaga mushrooms into small pieces with a hammer, then placing the Chaga mushroom pieces in a high-power grinder capable of grinding and crushing materials into ultrafine powder, and grinding the Chaga mushroom pieces to about 200 mesh, thereby producing the Chaga powder required for Rongpeptide Jiangtang Pills;Polygonatum odoratum powder is prepared by first cleaning the rhizomes of Polygonatum odoratum after harvesting, then sun-drying them until the moisture content is 20-30%. The rhizomes are then broken into small pieces using a pulper. The pieces are then further dried until the moisture content is less than 10%. The dried pieces are then crushed to approximately 200 mesh using a high-power grinder capable of grinding materials into ultrafine powder. This is the polygonatum odoratum powder required for Rongtide Jiangtang Pills.

[0006] The manual dough-making process of the Rongpeptide Hypoglycemic Pills is as follows: first, all raw materials are crushed into powder using a grinder, then all the powder is poured into a bag and mixed evenly. After mixing, the dough is kneaded into a dough bowl with refined honey, and then the dough is pinched into pieces. Each piece is weighed on a scale, and any excess is reduced or supplemented. Ensure that each piece weighs 11 grams. Then, each piece is rolled into a spherical pill. If rolled by hand, the dough is first kneaded and pressed with the palms of the hands to fully clumping the dough. Then, the palms are slowly separated. As the palms are separated, the rolled pill becomes increasingly rounder. When the whole pill is formed into a regular spherical shape, it is considered to be preliminarily rolled. After the preliminarily rolled pill is preliminarily rolled, a small amount of sesame oil is dipped into the palms and rubbed several times to evenly coat the palms. The preliminarily rolled pill is then taken and further rolled to make the Rongpeptide Hypoglycemic Pills shiny. The amount of refined honey used is 1-1.2 times the total weight of the powder used.

[0007] Usage and dosage of the Rongpeptide Hypoglycemic Pills: Chew: Mix all the powders in proportion to make honey pills, each pill weighs 11 grams, take 1 pill each time, 3 times a day, and every 7 days is a course of treatment.

[0008] The beneficial effects of the present invention are as follows: Rongpeptide Hypoglycemic Pills, which have blood sugar-lowering activity, utilize a variety of specially treated powdered materials with blood sugar-lowering activity. Leveraging the repairing function of active peptides and the antioxidant function of organic selenium, these are uniformly mixed and then made into honey pills with refined honey, thereby achieving the goal of lowering blood sugar levels after administration. Rongpeptide Hypoglycemic Pills have a very significant blood sugar-lowering effect. Experiments conducted by the inventors and others have shown that fasting blood sugar levels can be reduced by up to 2 points after one day of administration. The present invention is simple to manufacture, convenient to use, low in cost, and highly effective. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] The present invention will be further described below with reference to the accompanying drawings.

[0010] Figure 1 A diagram showing the overall size and appearance of Rongtide Jiangtang Pills, which have blood sugar-lowering activity. A one-yuan coin is used to compare the size of the Rongtide Jiangtang Pills.

[0011] Figure 2This diagram shows several finished products of Rongpeptide Jiangtang Pills, which have blood sugar-lowering activity, wrapped in plastic wrap. The plastic wrap shown is commercially available; in actual production, specialized wrapping paper can also be used. Wrapping the Rongpeptide Jiangtang Pills in plastic wrap or paper prevents adhesion between the pills and the wrapping film.

[0012] Figure 3 This diagram shows the blood sugar-lowering results after a subject, the inventor of the Rongtide Jiangtang Pill, took the pill. The number on the glucose meter in the figure represents the subject's actual fasting blood sugar level. The date next to it represents the date and time of the blood sugar measurement the following morning after taking the Rongtide Jiangtang Pill. The first measurement was taken at 7:08 AM on April 9, 2025. The subject took the Rongtide Jiangtang Pill three times a day, morning, noon, and evening, for a total of three pills, chewed orally. The second measurement was taken at 7:11 AM on April 10, 2025. The subject took the Rongtide Jiangtang Pill three times a day, morning, noon, and evening, for a total of three pills, chewed orally. The measurements were taken upon waking up the following morning. DETAILED DESCRIPTION

[0013] The following embodiments of the present invention are described in further detail with reference to the accompanying drawings and examples. The following examples are used to illustrate the present invention but are not intended to limit the scope of the present invention.

[0014] Example 1:

[0015] All raw materials used in the velvet peptide hypoglycemic pills with blood sugar lowering activity of the present invention need to be processed into powder. The powdered raw materials used are composed of 50% peptide-rich mealworm powder, 25% selenium-rich wheat leaf powder, 2% ginseng powder, 6% corn silk powder, 3% schisandra chinensis powder, 10% birch mushroom powder, and 4% polygonatum powder. All the powdered raw materials are crushed into particles with a particle size of 200 meshes by a grinder. The manual dough making process of the velvet peptide hypoglycemic pills is as follows: first, all the raw materials are crushed into powder by a grinder, then all the powders are poured into a bag and mixed evenly, and after mixing evenly, refined honey is used in a mixing basin to form dough, and then the dough is pinched into pieces, and each piece is weighed with a scale, and the excess is refunded and the deficiency is supplemented. Make sure that the weight of each dough piece is 11 grams, and then roll each dough piece into a ball. If you roll it by hand, first use the palms of your two hands to squeeze and press the dough piece to make the dough piece fully roll together, and then slowly separate the two palms when rolling. As the palms are separated, the dough piece will become more and more round. When the whole dough piece becomes a regular ball, it is considered to be preliminarily rolled. After the preliminarily rolling, dip a little sesame oil in the palm of your hand and rub the two palms a few times to evenly coat the palms with sesame oil. Take the dough piece that has just been preliminarily rolled and roll it further to make the surface of the Rongpeptide Hypoglycemic Pills shiny. The amount of refined honey used is 1-1.2 times the total weight of the powder used.

[0016] Usage and dosage: Chewable: Mix all powders in proportion and make into honey pills. Each pill weighs 11 grams. Take according to the dosage instructions, usually 1 pill (11 grams) each time, 3 times a day, and one course of treatment is 7 days.

[0017] Applicable symptoms: polydipsia, polyuria, polyphagia and weight loss, namely the "three mores and one less" symptoms; fatigue, itchy skin, slow wound healing, blurred vision; diabetic ketoacidosis, hyperosmolar hyperglycemic syndrome, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and cardiovascular disease.

[0018] Notes:

[0019] 1. Pregnant women should use with caution: Due to the risk of allergies to the active peptides in the prescription, long-term high-dose (>9g / day) consumption of ginseng may induce insomnia, palpitations, or abnormal blood sugar. There is a lack of safety data for pregnant women, lactating women, and those with abnormal liver and kidney function to consume corn silk and Schisandra chinensis. Pregnant women should use with caution.

[0020] 2. People with allergies should avoid eating mealworms: Mealworms contain large molecular weight heterologous proteins. People who are allergic to insect protein should avoid eating them.

[0021] 3. It is not suitable for patients with Yin deficiency and hyperactivity of fire, or real heat syndrome: If the patient shows symptoms of Yin deficiency and hyperactivity of fire (such as hot flashes, night sweats, fever in the five hearts, etc.), it is not suitable for use, especially not for excessive use.

[0022] 4. Professional guidance: Consult a Chinese medicine practitioner before use to avoid misuse.

[0023] 5. Diet adjustment: Avoid eating raw, cold, greasy, and spicy foods during the medication period to avoid affecting the efficacy of the medicine.

[0024] Peptide-rich mealworm powder is the raw material with the highest content in Rongpeptide Jiangtang Pills. It is made from the seventh or eighth-instar mature larvae of mealworms, accounting for half of the entire powder. The protein content is 50-57%, which is significantly higher than that of common animal foods such as eggs and beef, and is easy to digest and absorb. The active polypeptides in mealworm powder are mainly dipeptidyl peptidase IV (DPP-IV) and α-glucosidase inhibitory peptides, with a content of 0.2-0.5%. The chitin and antimicrobial peptides in mealworms have the effect of lowering blood pressure and regulating blood lipids and blood sugar. The fat content of mealworms is 27.3-37.6%, and the content of unsaturated fatty acids in the fat of mealworms is relatively high, accounting for 2.5% of the total fatty acids. Mealworm powder contains 80.7% of the total protein and 34.0% of the total protein, with a fatty acid profile similar to that of rice bran and sesame oil. Its high protein and fat content provides nutritional benefits. Furthermore, mealworm powder contains various immunomodulatory factors and polysaccharides that stimulate interferon production and enhance disease resistance. Its unique chitin and bioactive peptides have antibacterial, disease-fighting, and cell-damage repair properties, helping to boost immunity. During production, mealworms must be sourced reliably, freshly, and safely, avoiding unclean or spoiled mealworms to ensure food safety. Mealworm larvae and adults prefer darkness and often lurk beneath the surface of feed. They are omnivorous, consuming a variety of grains, oilseeds, and byproducts of grain and oil processing, as well as a variety of vegetables and leaves. They tolerate high-density stockings and have an optimal temperature range of 15-30°C. They grow fastest at 25-28°C. They will not feed or grow below 10°C, and will overheat and die at temperatures exceeding 35°C. When rearing mealworms at high densities, the temperature inside the swarm often rises by more than 5°C above room temperature. Therefore, it's important to monitor the actual temperature within the swarm to prevent overheating. A relative humidity of 60% to 79% and a feed moisture content of around 15% promote good growth. Regarding mealworm rearing, consider the following: First, consider the equipment. Mealworm rearing requires a smooth interior and a depth of at least 15 cm to prevent the worms from crawling out. Ideally, use a rectangular wooden box. For example, a rectangular box 100 cm long, 10 cm wide, and 50 cm high can be constructed by nailing boards together. The bottom should be secured with plywood, and the sides should be taped with wide tape to ensure the interior is smooth and prevent the worms from crawling out. Alternatively, for adult worms to lay eggs, place an 80 cm long, 40 cm wide, and 10 cm high wooden box with a 51-mesh wire mesh (used for sifting wheat bran) nailed to the bottom. Place the adult worms inside the box and allow them to lay eggs, extending their tails through the mesh. A layer of bran can be placed inside the box to prevent damage. Instructions: Place a 100mm long, 50mm wide, and 10mm high square wooden box at the bottom, and a 80cm long, 40cm wide, and 10cm high iron sieve on top. Place the eggs of adult insects inside, and sprinkle with bran, vegetable leaves, fruit peels, etc., allowing them to feed freely. When spreading the feed, the thickness should not exceed 1cm to prevent the tails of the adults from extending beyond the iron sand net when they lay eggs. When the adults have been laying eggs for about 7 days, replace the egg-laying box. The egg-laying box should be placed separately, and care should be taken to avoid squeezing the eggs to avoid damage.When the eggs hatch, there's no need to add feed. The bran in the original egg-laying box is sufficient for the larvae. As the worms grow, add feed and regularly screen their feces according to their needs. Secondly, consider feed: Mealworms can be fed from a wide variety of sources, including wheat bran, cornmeal, soybean cake, carrots, vegetable leaves, and fruit peels. A typical mealworm feed ratio is 80% wheat bran, 10% cornmeal, and 10% peanut meal. A proper combination of these feeds is beneficial to the growth and development of mealworms while also conserving feed. Please note that all feeds used for Rongtide Hypoglycemic Pills must be processed, that is, after determining which piece of land will be used to produce wheat bran, corn, bean cake, carrots, vegetable leaves or melon and fruit peels, 20-30 days before the harvest of these feed raw material plants, commercially available effective foliar fertilizers should be sprayed on the leaves of the raw material plants used to ensure that the organic selenium content in the produced feed is not less than 40 micrograms / kg. The selenium content in the mealworms fed with such feed must exceed the national standard of 40 micrograms / kg. The produced mealworms must be tested by atomic fluorescence spectrometer (AFS) or inductively coupled plasma mass spectrometer (IPC-MS). Only those with test results higher than the national standard of 40 micrograms / kg can be used. At this time, the mealworms can be called mealworms. Next, consider temperature: Mealworms are relatively cold-resistant. Mature larvae can overwinter at temperatures as low as -2°C, while younger larvae die en masse at around 0°C. Their survival limit is 2°C, with development starting at 10°C and hibernation occurring above 8°C. Their optimal temperature range is 25-30°C. Growth and development are fastest at 32°C, but prolonged exposure to high temperatures can lead to disease and death above 32°C (all temperatures refer to internal body temperature). For larvae older than the fourth instar, when the air temperature is 26°C and the moisture content of the feed is 15%-18%, the internal body temperature can rise 110°C above the air temperature, reaching 36°C. Cooling measures should be taken promptly to prevent temperatures from exceeding 38°C, especially during the hot summer months. Next, consider humidity: Mealworms are drought-tolerant and can survive on feed with a moisture content below 10%. However, in dry environments, their growth and development are slowed, their body weight decreases, and a significant amount of feed is wasted. The ideal feed moisture content is 15%, and the relative humidity is 50% to 80%. If the feed moisture content exceeds 18% and the air humidity exceeds 85%, growth and development will be slowed and adults will be more susceptible to disease. If the breeding room is too dry, sprinkle some water; if the humidity is too high, ventilate the room promptly. Finally, consider light: Mealworms, originally warehouse pests, are photophobic and active, both day and night. Female adults lay more eggs in dimly lit areas than in bright light. After mealworm larvae are produced, they are dried as quickly as possible to a moisture content of 0.87-9.83%. This dried mealworm is then crushed to a 200-mesh particle size using a grinder to produce peptide-rich mealworm powder. Peptide-rich mealworm powder is added to Rongpeptide Jiangtang Pills at a concentration of 50%. Active peptides are short-chain molecules composed of amino acids linked by peptide bonds, and they typically possess specific biological activities.Studies have shown that certain bioactive peptides may affect blood sugar levels through various mechanisms, but the specific effects vary depending on the type of peptide, its source, and its pathway of action. Potential mechanisms by which bioactive peptides regulate blood sugar include: First, bioactive peptides can promote insulin secretion. Certain bioactive peptides (such as those derived from fish collagen, soy, or whey protein) may stimulate pancreatic beta cells to secrete insulin, thereby directly lowering blood sugar. For example, GLP-1 (glucagon-like peptide-1) analogs have been used to treat diabetes by activating receptors to promote insulin release. Second, bioactive peptides can improve insulin sensitivity. Bioactive peptides may enhance the sensitivity of muscle, fat, and other tissues to insulin by regulating insulin signaling pathways (such as the PI3K / Akt pathway), thereby reducing insulin resistance. For example, soy peptides and marine collagen peptides have been shown to improve insulin resistance in animal studies. Third, bioactive peptides can inhibit gluconeogenesis and glycogenolysis. Some peptides may lower fasting blood sugar by inhibiting glucose production (gluconeogenesis) in the liver or reducing glycogenolysis. Next, active peptides can delay carbohydrate absorption, inhibit α-glucosidase or α-amylase activity, and slow intestinal carbohydrate digestion and absorption, similar to the effects of acarbose. For example, wheat germ peptides and bitter melon peptides may have such functions. Finally, active peptides have antioxidant and anti-inflammatory effects. Chronic inflammation and oxidative stress are important causes of insulin resistance. Active peptides indirectly improve blood sugar regulation by scavenging free radicals and inhibiting inflammatory factors (such as TNF-α and IL-6). At the same time, data show that the most important function of active peptides is repair. When active peptides enter the body through direct absorption or intestinal digestion and absorption and are converted into specific active peptides, they can exert powerful repair activity, quickly and promptly repairing various damages during cellular metabolism and restoring cells to optimal activity. For example, "Bioactive peptides and proteins for tissue repair: an update on proteins and peptides with regenerative potential" describes the mechanisms of action of various active peptides in tissue repair, including antioxidant, immune cell regulation, cell survival promotion, recruitment of repair cells, and promotion of cell adhesion and differentiation. The current status and limitations of active peptide hypoglycemic research: First, experimental evidence: Most studies focus on cell or animal models, clinical trial data are limited, and dose-response relationships are not yet clearly defined. Some active peptides demonstrate hypoglycemic effects in vitro, but their bioavailability in humans may be low. Second, safety: naturally derived active peptides are generally safer, but allergy risks (such as soy and milk-derived peptides) require caution.Selenium-enriched wheat leaf powder is a commercially available foliar fertilizer that has been tested many times to be effective in enriching selenium. When the winter wheat seedlings grow to about 10 cm, spray it on the leaves of the winter wheat. After 20-30 days of treatment, harvest the wheat seedlings. This is exactly when the winter wheat seedlings begin to grow vigorously but cannot grow vigorously. At this time, if the wheat seedlings grow vigorously, farmers will use sheep to gnaw them or machines to press the seedlings. Therefore, when harvesting wheat leaves after spraying foliar fertilizer, only the wheat leaves are harvested without damaging the wheat roots, wheat stems and growth points, that is, the cutting position is 2-3 cm from the ground. According to experiments, harvesting at this time will not only not reduce the yield of winter wheat, but when harvesting the following year, the wheat grains are still very full and the yield is slightly increased, generally by 3-5%. After the wheat leaves are harvested, first The wheat leaves are washed and then dried in the sun or directly dried after draining. When the moisture content of the wheat leaves drops to 10% or less, they are crushed with an agricultural grinder. At this point, the wheat leaves are not too fine, generally around 10 mesh. The previously crushed wheat leaves are then crushed with a high-power grinder capable of grinding materials into ultrafine powder. The resulting wheat leaf powder is guaranteed to be around 200 mesh, thus making the selenium-enriched wheat leaf powder required for the Rongpeptide Jiangtang Pills. The selenium content of the selenium-enriched wheat leaf powder must be tested before use. The selenium content in the selenium-enriched wheat leaf powder must exceed 40 micrograms / kg before use, as the national selenium-enriched standard is 40 micrograms / kg. The amount of wheat leaf powder added to the Rongpeptide Jiangtang Pills is 25%. Organic selenium refers to compounds formed by the combination of selenium and organic molecules (such as amino acids and proteins), such as selenomethionine (Se-Met), selenocysteine ​​(Se-Cys), and selenium in selenium yeast. Compared to inorganic selenium (such as sodium selenite), organic selenium has higher bioavailability and safety. Research has shown that selenium, an essential trace element for the human body, may affect blood glucose metabolism through multiple pathways. Potential mechanisms by which organic selenium regulates blood glucose include: First, organic selenium has antioxidant properties. Selenium is a core component of glutathione peroxidase (GPx), which scavenges free radicals and reduces oxidative stress. Oxidative stress is a key factor in insulin resistance and pancreatic beta-cell damage. Selenium indirectly promotes blood glucose stability by protecting pancreatic cells and improving insulin signaling pathways (such as PI3K / Akt). Second, organic selenium can modulate the insulin signaling pathway. Selenium may enhance insulin sensitivity in tissues such as muscle and adipose tissue by activating insulin receptor substrates (IRS) and downstream signaling molecules. Third, organic selenium has anti-inflammatory effects. By inhibiting inflammatory pathways such as NF-κB, selenium reduces the release of inflammatory factors (such as TNF-α and IL-6), thereby improving insulin resistance associated with chronic inflammation. Finally, organic selenium can affect thyroid hormone metabolism. Selenium is an important cofactor for thyroid hormone deiodinase, and abnormal thyroid function is closely associated with impaired glucose metabolism. Selenium indirectly regulates blood sugar by maintaining stable thyroid function. The dose-effect relationship between organic selenium and blood sugar is as follows: Appropriate supplementation with organic selenium may improve blood sugar levels.Animal studies have shown that supplementing diabetic mice with selenium yeast (200 μg / kg) can reduce fasting blood glucose and improve insulin resistance. Observational studies in some populations have found a U-shaped relationship between serum selenium levels and diabetes risk: both low and high levels may increase risk, with moderate levels (60-120 μg / L) being the safest. Excessive selenium intake may increase blood glucose. Epidemiological evidence suggests that long-term excessive selenium intake (>200 μg / day) may increase the risk of type 2 diabetes, possibly through increased oxidative stress or abnormalities in the insulin signaling pathway. The proposed mechanism is that high-dose selenium may induce endoplasmic reticulum stress, interfere with pancreatic beta-cell function, or inhibit insulin signaling through overexpression of selenoprotein P (SelP). Current research and controversy include supporting evidence that selenium supplementation may be beneficial for glycemic control in selenium-deficient populations (such as those in Keshan disease-affected areas of China), and that selenomethionine has been shown in clinical trials to improve oxidative stress markers in diabetic patients. However, the results of the SELECT trial showed that high-dose selenium supplementation (200 μg / day) did not show a blood sugar-lowering effect, but may increase the risk of diabetes. The reason for this result may be that the selenium used was inorganic selenium. At the same time, the results of the meta-analysis also showed that the effect of selenium on blood sugar was heterogeneous, which may be due to baseline selenium levels and genetic differences among the population (such as GPx gene polymorphisms). Ginseng powder is made from commercially available ginseng. The ginseng used must be eight years or older and can be grown in gardens or forests, with forest-grown ginseng being preferred. Fresh ginseng should be used for ginseng powder processing, rather than pre-dried white ginseng or sun-dried ginseng. Fresh ginseng is used because it is first crushed into small pieces of approximately 10 mesh in a grinder. These pieces are then dried and then pulverized to approximately 200 mesh in a high-power grinder capable of grinding the material into an ultrafine powder. This creates the ginseng powder needed for Rongpeptide Jiangtang Pills. The amount of ginseng powder used in Rongpeptide Jiangtang Pills is 2%. Ginseng (Panax ginseng) is a traditional Chinese medicinal herb whose roots and rhizomes contain a variety of active ingredients, including ginsenosides, polysaccharides, and peptides. Studies have shown that ginseng may regulate blood sugar metabolism through multiple targets, but its effects are bidirectional and dose-dependent, and the effects are affected by the type of ginseng (such as American ginseng, Korean ginseng), the extraction method, and individual differences. The potential mechanism of ginseng in regulating blood sugar: First, ginseng can promote insulin secretion and protect pancreatic beta cells. Ginsenosides (such as Rb1, Rg1, Re) may stimulate pancreatic beta cells to secrete insulin by activating adenylate cyclase (AC) or inhibiting KATP channels. Ginseng also has antioxidant effects: ginseng can reduce oxidative damage to pancreatic beta cells (such as inhibiting ROS generation) and maintain their functional integrity.Secondly, ginseng can improve insulin resistance. Ginsenosides can enhance insulin sensitivity in skeletal muscle, liver, and adipose tissue by activating the PI3K / Akt and AMPK signaling pathways, promoting glucose uptake and utilization. Furthermore, ginseng can inhibit the expression of inflammatory factors (such as TNF-α and IL-6), alleviating insulin resistance caused by chronic inflammation. Thirdly, ginseng can regulate the activity of enzymes involved in glucose metabolism. Ginseng extracts can downregulate the activity of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) in the liver, reducing hepatic glucose output and inhibiting gluconeogenesis. Ginseng activates the glucose transporter 4 (GLUT4) and hexokinase (HK), accelerating glucose utilization in peripheral tissues and promoting glycolysis. Finally, ginseng can regulate the gut microbiota and short-chain fatty acids (SCFAs). Ginseng polysaccharides may indirectly enhance insulin sensitivity by improving the structure of the gut microbiota (e.g., increasing the abundance of probiotics) and promoting the production of SCFAs (such as butyrate). Experimental and clinical research evidence for ginseng's blood sugar regulation: First, animal studies have shown that supplementing diabetic rats with ginsenosides (50-100 mg / kg) significantly lowers fasting blood sugar and improves glucose tolerance, with effects comparable to metformin. Korean ginseng extract has been shown to reduce fat accumulation and lower insulin resistance in obese mice. Second, clinical trials have shown short-term effects: some studies have shown that taking red ginseng (3-6 g / day) for 8 weeks significantly reduces fasting blood sugar (FPG) and postprandial blood sugar (PPG) in patients with type 2 diabetes. Long-term controversy: Meta-analyses have shown inconsistent improvements in HbA1c (glycosylated hemoglobin), potentially due to differences in dosage, ginseng type, and treatment duration. Corn silk powder is made by collecting the silk directly from the surface of corn kernels during corn cob breaking after harvesting. Because corn silk is long and fluffy, it must be cleaned before being ground into powder. Then, it is sun-dried to a moisture content of 20-30%, chopped with a guillotine into 1-2 cm long pieces. The chopped corn silk is then further dried to a moisture content of less than 10%. A high-powered grinder capable of grinding the dried and chopped corn silk into an ultrafine powder is used to grind the dried and chopped corn silk to a size of approximately 200 mesh, thus producing the corn silk powder required for Rongpeptide Jiangtang Pills. The amount of corn silk powder added to Rongpeptide Jiangtang Pills is 6%. Corn silk, the style and stigma of the pistil of corn (Zea mays), is commonly used in traditional medicine as a diuretic, antihypertensive, and blood sugar regulator. Modern research indicates that corn silk contains active ingredients such as flavonoids (such as kaempferol and quercetin), polysaccharides, saponins, organic acids (such as caffeic acid and chlorogenic acid), and minerals, which may affect blood sugar metabolism through various pathways. The potential mechanism of corn silk in regulating blood sugar: First, corn silk can inhibit the activity of α-glucosidase: the flavonoids and polysaccharides in corn silk can inhibit intestinal α-glucosidase, delay the decomposition of carbohydrates into glucose, and reduce the increase in blood sugar after meals (similar to the effect of acarbose).Secondly, corn silk can improve insulin sensitivity: Corn silk extract may promote glucose uptake and utilization in skeletal muscle and liver by activating AMP-activated protein kinase (AMPK). Corn silk also possesses anti-inflammatory and antioxidant properties. Its flavonoids can reduce oxidative stress and inflammatory factors (such as IL-6 and TNF-α), alleviating insulin resistance. Thirdly, corn silk can protect pancreatic beta cells: Corn silk polysaccharides scavenge free radicals (ROS), reducing oxidative damage to pancreatic beta cells and maintaining insulin secretion. Finally, corn silk can regulate hepatic glucose metabolism by inhibiting the activity of key gluconeogenic enzymes (such as PEPCK and G6Pase), reducing hepatic glucose output, while promoting hepatic glycogen synthesis and lowering fasting blood glucose. Experimental and clinical evidence for corn silk's blood glucose regulation includes animal studies: In diabetic rats, oral administration of a corn silk aqueous extract (200-400 mg / kg) for four weeks resulted in a 20-30% decrease in fasting blood glucose and a significant improvement in glucose tolerance. Corn silk flavonoids can also reduce the homeostasis model (HOMA-IR) of insulin resistance in mice fed a high-fat diet. Secondly, clinical trials: Small-scale human trials showed that after 8 weeks of daily consumption of corn silk tea (5-10g of dry product) by patients with type 2 diabetes, postprandial blood sugar levels decreased by approximately 15%, but HbA1c levels did not improve significantly. It is important to note that the combination of corn silk and conventional hypoglycemic drugs (such as metformin) may enhance efficacy, but caution is advised regarding the risk of hypoglycemia. Schisandra powder is prepared by washing the harvested schisandra berries, then sun-drying them to a moisture content of 20-30%. The berries are then broken into small pieces using a blender. The pieces are then further dried to a moisture content of less than 10%. The dried pieces are then crushed to approximately 200 mesh using a high-powered grinder capable of grinding the material into ultrafine powder, creating the schisandra powder needed for Rongpeptide Jiangtang Pills. The amount of schisandra powder added to Rongpeptide Jiangtang Pills is 3%. Schisandra chinensis (Schisandra chinensis) is a traditional Chinese medicinal herb. Its fruit contains active ingredients such as lignans (such as schisandrin A and B), polysaccharides, organic acids, and volatile oils. Studies have shown that schisandra chinensis may affect blood glucose metabolism through pathways such as regulating insulin secretion, improving insulin resistance, and providing antioxidant benefits. However, these effects are complex and dose-dependent, requiring careful evaluation based on research evidence. The potential mechanisms by which schisandra chinensis regulates blood glucose include, firstly, promoting insulin secretion and protecting pancreatic β-cells. The lignans in schisandra chinensis (such as schisandrin A and schisandrol A) may activate Ca in β-cells. 2+Channels or inhibit KATP channels to stimulate insulin secretion; Schisandra chinensis also has antioxidant effects, by scavenging free radicals (ROS), reducing oxidative damage to pancreatic beta cells and maintaining their function. Secondly, Schisandra chinensis can improve insulin sensitivity: Schisandra chinensis polysaccharides may promote glucose uptake in skeletal muscle and adipose tissue by activating the PI3K / Akt and AMPK signaling pathways; Schisandra chinensis can inhibit the expression of inflammatory factors (such as TNF-α, IL-6) and reduce insulin resistance associated with chronic inflammation. Thirdly, Schisandra chinensis can regulate liver glucose metabolism: inhibit key enzymes of gluconeogenesis (such as PEPCK and G6Pase), reduce liver glucose output; promote liver glycogen synthesis, and lower fasting blood sugar. Finally, Schisandra chinensis can inhibit intestinal sugar absorption: some components in Schisandra chinensis may inhibit the activity of α-glucosidase and delay the decomposition of carbohydrates into glucose (similar to the effect of acarbose). Experimental and clinical research evidence that Schisandra chinensis lowers blood sugar levels: First, animal studies have shown that after four weeks of gavage with Schisandra chinensis extract (100-200 mg / kg) in diabetic mice, fasting blood sugar levels dropped by approximately 25%, and insulin sensitivity significantly improved. Schisandra chinensis lignans can alleviate high-fat diet-induced hepatic steatosis, indirectly improving glucose metabolism. Second, clinical trials have shown that after 12 weeks of taking Schisandra chinensis capsules (containing 30 mg / day of lignans) in patients with type 2 diabetes, fasting blood sugar and glycosylated hemoglobin (HbA1c) decreased slightly, but the effect was weaker than that of conventional glucose-lowering drugs. It is important to note that when Schisandra chinensis is used in combination with metformin, some patients are at increased risk of hypoglycemia, suggesting that dosage adjustments should be made with caution. Chaga powder is made by first cleaning the harvested Chaga mushrooms, drying them in the sun, and then breaking them into small pieces with a hammer. These pieces are then placed in a high-powered grinder capable of grinding materials into ultrafine powders, where they are crushed to approximately 200 mesh. This is the Chaga powder needed for Rongpeptide Jiangtang Pills. Chaga powder is added to Rongpeptide Jiangtang Pills at a dosage of 10%. Chaga (Inonotus obliquus), a medicinal fungus that grows on birch trees, is commonly used in traditional medicine for its immune-boosting, anti-inflammatory, and antioxidant properties. Modern research has revealed that Chaga contains active ingredients such as polysaccharides, triterpenes, polyphenols (such as melanin), sterols, and trace elements, which may regulate blood sugar metabolism through multiple targets. The potential mechanism of Chaga in regulating blood sugar: First, Chaga can improve insulin sensitivity: On the one hand, the Chaga polysaccharides contained in Chaga may promote the uptake and utilization of glucose by skeletal muscle and liver by activating AMP-activated protein kinase (AMPK), thereby reducing insulin resistance; on the other hand, the anti-inflammatory factors contained in Chaga: triterpenes and polyphenols can reduce the levels of inflammatory factors such as TNF-α and IL-6, and alleviate insulin resistance associated with chronic inflammation.Secondly, the melanin and polyphenols in Chaga have strong antioxidant properties, scavenging free radicals (ROS), reducing oxidative damage to pancreatic beta cells, maintaining insulin secretion, and protecting pancreatic beta cells. Furthermore, Chaga extract may downregulate the activity of PEPCK (phosphoenolpyruvate carboxykinase) and G6Pase (glucose-6-phosphatase) in the liver, reducing gluconeogenesis, lowering fasting blood sugar, and inhibiting gluconeogenesis and hepatic glucose output. Furthermore, Chaga polysaccharides may inhibit α-glucosidase activity, delaying the breakdown of carbohydrates into glucose, reducing postprandial blood sugar fluctuations, and delaying intestinal sugar absorption. Experiments have shown that after four weeks of oral administration of Chaga polysaccharides (100-200 mg / kg) to diabetic mice, fasting blood sugar decreased by approximately 20-30%, and the insulin sensitivity index (HOMA-IR) significantly improved. Chaga aqueous extract can reduce liver fat accumulation and improve glucose tolerance in rats fed a high-fat diet. Cell experiments have shown that Chaga triterpenoids can promote glucose uptake by adipocytes in vitro, similar to metformin. Small-scale human trials have shown that after eight weeks of daily use of Chaga extract (containing 500 mg of polysaccharides) in patients with type 2 diabetes, fasting and postprandial blood sugar levels decreased by approximately 10% and 15%, respectively, but no significant change in HbA1c was observed. Of course, using Chaga alone for glucose-lowering studies has its limitations: existing clinical trials have small sample sizes (<100 cases) and lack long-term follow-up data, so the effectiveness still needs to be further verified. Polygonatum odoratum powder is made by harvesting and cleaning the rhizomes of Polygonatum odoratum, then sun-drying them until the moisture content is 20-30%. The rhizomes are then broken into small pieces using a pulper. The pieces are then further dried to a moisture content of less than 10%. The dried pieces are then crushed to a size of approximately 200 mesh using a high-power grinder capable of grinding materials into ultrafine powder. This powder is then added to the Rongpeptide Jiangtang Pills at a rate of 4%. Polygonatum odoratum, also known as wilting radix, is a plant of the genus Polygonatum in the Liliaceae family. Its rhizomes are used in traditional Chinese medicine to nourish yin, moisten dryness, and promote the production of body fluids and quench thirst. Modern research indicates that Polygonatum odoratum contains active ingredients such as polysaccharides, saponins, flavonoids (such as quercetin), amino acids, and trace elements, which may regulate blood sugar metabolism through multiple pathways. The potential mechanism of Polygonatum odoratum in regulating blood sugar: First, Polygonatum odoratum can improve insulin sensitivity: Polygonatum odoratum polysaccharides can activate the PI3K / Akt and AMPK signaling pathways, promote the uptake of glucose by skeletal muscle and adipose tissue, and reduce insulin resistance; Polygonatum odoratum can also inhibit the expression of inflammatory factors (such as TNF-α, IL-6), and alleviate insulin resistance associated with chronic inflammation.Secondly, Polygonatum odoratum can promote insulin secretion and protect pancreatic beta cells. Flavonoids in Polygonatum odoratum (such as quercetin) scavenge free radicals (ROS), reducing oxidative damage to pancreatic beta cells, exerting antioxidant effects and maintaining their secretory function. Animal studies have shown that Polygonatum odoratum extract may indirectly stimulate insulin release by regulating the secretion of GLP-1 (glucagon-like peptide-1). Thirdly, Polygonatum odoratum can reduce hepatic glucose output by inhibiting the activity of key gluconeogenic enzymes PEPCK and G6Pase. It also regulates hepatic glucose metabolism by promoting hepatic glycogen synthesis and lowering fasting blood glucose levels. Finally, Polygonatum odoratum polysaccharides may inhibit intestinal α-glucosidase activity, delaying carbohydrate breakdown and absorption, and reducing postprandial blood glucose fluctuations. In animal studies, oral administration of Polygonatum odoratum polysaccharides (100-200 mg / kg) to diabetic rats showed a 20-30% decrease in fasting blood glucose after four weeks, and a significant improvement in the insulin sensitivity index (HOMA-IR). Treating mice fed a high-fat diet with ethanol extract of Polygonatum odoratum showed that it could reduce visceral fat accumulation and improve impaired glucose tolerance. In cell experiments, in vitro experiments with Polygonatum odoratum saponins showed that Polygonatum odoratum saponins could promote glucose uptake in adipocytes, similar to insulin sensitizers (such as rosiglitazone). In a small-scale clinical human trial, patients with type 2 diabetes took Polygonatum odoratum extract (containing 300 mg of polysaccharides) daily. After 12 weeks, the average fasting blood sugar decreased by about 10%, but the improvement in glycated hemoglobin (HbA1c) was limited. Limitations of using Polygonatum odoratum alone for hypoglycemic experiments: the sample size of existing studies is small (usually <100 cases), and there is a lack of long-term follow-up data. The hypoglycemic effect needs further verification.

[0025] Among the above-mentioned powders, the small molecule bioactive peptides contained in the peptide-rich mealworm powder can repair damaged cell structures, and the high content of organic selenium obtained by these methods can quickly and efficiently decompose or remove the waste reactive oxygen free radicals produced by cell metabolism, play an antioxidant role, and thus provide a complete and efficient environment for cell growth and metabolism, thereby greatly reducing the chance of cell damage; ginseng has the effect of replenishing vital energy, can enhance the body's positive energy, and improve the body's disease resistance; in addition, ginseng can also nourish the spleen and lungs, promote the production of body fluids and quench thirst, calm the mind and improve intelligence, regulate immune function, resist fatigue, and lower blood Sugar, anti-tumor; Chaga is a medicinal fungus that parasitizes on birch trees and mainly grows in the extremely cold zone between 40 and 50 degrees north latitude. The polysaccharide component in Chaga is one of the natural substances with the best blood sugar lowering effect known so far. Its blood sugar lowering effect can last for 48 hours. Generally, one course of treatment can reduce glycosylated hemoglobin by 0.1-0.2 points and reduce the incidence of complications by 40-50%. In addition, Chaga also has the functions of protecting cardiovascular, anti-tumor, anti-inflammatory and antibacterial, antioxidant and anti-aging, protecting the liver, relieving joint pain, improving skin condition, improving nervous system function, and enhancing immunity. Fasting blood glucose (FPG) refers to the blood glucose value measured after not eating for at least 8 hours. The normal range is 3.9-6.1mmol / L. Its clinical significance is that when FPG ≥ 7.0mmol / L, it may indicate diabetes and requires repeated testing for confirmation; when the FPG value is 6.1-6.9mmol / L, it indicates impaired fasting blood glucose (IFG), which is a pre-diabetes state; FPG < 3.9mmol / L, it can be preliminarily identified as hypoglycemia, but it needs to be evaluated in combination with symptoms. Figure 3 It can be seen that after the inventor and many other people took the medicine as experimenters, the test results showed that the fasting blood sugar value could be reduced by up to 2 points, and the blood sugar lowering effect was very obvious.

[0026] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principles of the present invention. These improvements and modifications of the above assumptions should also be regarded as the scope of protection of the present invention.

Claims

1. The raw materials used in the Rongpeptide Hypoglycemic Pills, which have the activity of lowering blood sugar, need to be processed into powder. All the powdered raw materials are crushed into fine powder with a particle size of 200 mesh using a grinder. The characteristics are: The powdered raw material consists of 50% peptide-rich mealworm powder, 25% selenium-rich wheat leaf powder, 2% ginseng powder, 6% corn silk powder, 3% schisandra powder, 10% birch powder, and 4% polygonatum powder. The peptide-rich mealworm powder is made from the seventh or eighth-instar mature larvae of the mealworm. The selenium-rich wheat leaf powder is a commercially available foliar fertilizer that has been tested multiple times to be effective in selenium enrichment. When the winter wheat seedlings grow to about 10 cm, the wheat leaves are sprayed on the leaves. After 20-30 days of treatment, the wheat leaves are harvested. After harvesting, the wheat leaves are first washed, and after washing, they are placed in the sun to dry or dried directly after draining. When the moisture in the wheat leaves drops to 10% or below, they are first crushed with an agricultural crusher. The leaves are not too broken, generally about 10 meshes, and then the previously broken wheat leaves are crushed with a high-power grinder that can grind the material into ultrafine powder. The obtained wheat leaf powder must be guaranteed to be about 200 meshes, thereby making the selenium-rich wheat leaf powder required for the peptide hypoglycemic pills; the selenium content of the selenium-rich wheat leaf powder must be tested in advance before use, and the selenium content in the selenium-rich wheat leaf powder must be more than 40 micrograms / kg after testing before it can be used; ginseng powder is a powder made from commercially available ginseng, and the ginseng used must be ginseng that has grown for 8 years or more. When processing ginseng powder, fresh ginseng needs to be used. During processing, the fresh ginseng is first crushed into small ginseng pieces of about 10 meshes with a grinder, and then the small ginseng pieces are dried, and then used to grind A high-power grinder that grinds materials into ultrafine powders crushes the dried ginseng small pieces into about 200 meshes, thereby making the ginseng powder required for Rongpeptide Jiangtang Pills; corn silk powder is obtained by directly collecting the corn silk on the surface of the kernels when the corn is harvested and broken into pieces. Before powdering, the corn silk needs to be cleaned first, then dried to a moisture content of 20-30%, and chopped with a guillotine to a length of 1-2 cm. Then, the chopped corn silk is further dried to a moisture content of less than 10%, and a high-power grinder that can grind materials into ultrafine powder is used to crush the dried chopped corn silk to about 200 meshes, thereby making the corn silk powder required for Rongpeptide Jiangtang Pills; Schisandra powder is obtained by first grinding the Schisandra fruit after harvesting. The schisandra fruit is cleaned and then dried in the sun until the moisture content is 20-30%. The schisandra fruit is broken into small pieces with a beater. The schisandra fruit pieces are then further dried until the moisture content is less than 10%. The dried schisandra fruit pieces are crushed to about 200 mesh with a high-power grinder capable of grinding and crushing materials into ultrafine powder, thereby producing the schisandra fruit powder required for the Rongpeptide Jiangtang Pills. The chaga powder is prepared by first cleaning the chaga after harvesting, drying the surface moisture in the sun, and breaking the chaga into small pieces with a hammer. The chaga pieces are then placed in a high-power grinder capable of grinding and crushing materials into ultrafine powder and crushed to about 200 mesh, thereby producing the chaga powder required for the Rongpeptide Jiangtang Pills.Polygonatum odoratum powder is prepared by first cleaning the rhizomes of Polygonatum odoratum after harvesting, then sun-drying them until the moisture content is 20-30%. The rhizomes are then broken into small pieces using a pulper. The pieces are then further dried until the moisture content is less than 10%. The dried pieces are then crushed to approximately 200 mesh using a high-power grinder capable of grinding materials into ultrafine powder. This is the polygonatum odoratum powder required for Rongtide Jiangtang Pills.

2. The Rongpeptide Hypoglycemic Pills having blood sugar lowering activity according to claim 1, characterized in that: The manual dough-making process of the Rongpeptide Hypoglycemic Pills is as follows: first, all raw materials are crushed into powder by a crusher, then all the powder is poured into a bag and mixed evenly, after mixing evenly, dough is formed by using refined honey in a mixing basin, and then the dough is pinched into pieces, each piece is weighed with a scale, and any excess is reduced or supplemented to ensure that the weight of each piece is 11 grams, and then each piece is rolled into a spherical pill. If rolled by hand, the palms of two hands are first used to squeeze and press the dough to fully roll together, and then the two palms are slowly separated during the rolling process. As the palms are separated, the rolled piece becomes more and more round. When the whole piece is formed into a regular spherical shape, it is considered to be preliminarily rolled. After the preliminarily rolling is completed, a little sesame oil is dipped into the palms, and the two palms are rubbed several times to evenly coat the palms with the sesame oil, and the preliminarily rolled piece is taken and further rolled to make the Rongpeptide Hypoglycemic Pills have a shiny appearance. The amount of refined honey used is 1-1.2 times the total weight of the powder used.

3. The Rongpeptide Hypoglycemic Pills having blood sugar lowering activity according to claim 1, characterized in that: Usage and dosage of the Rongpeptide Hypoglycemic Pills: Chew: Mix all the powders in proportion to make honey pills, each pill weighing 11 grams, take 1 pill each time, 3 times a day, and 7 days as a course of treatment.

Images