A raw material addition device for pharmaceutical production and processing

Abstract

This invention relates to the field of pharmaceutical manufacturing technology, specifically disclosing a raw material addition device for pharmaceutical manufacturing and processing, comprising: a main frame; a rotating frame, the rear end of which is rotatably mounted on the front middle of the main frame via bearings, the rear end of which extends rotatably beyond the rear of the main frame, a first rotating cavity being formed at the top of the front side of the rotating frame, and a second rotating cavity being formed in the middle of the front side of the rotating frame; and a first bevel gear, which is disposed in the middle of the front side of the main frame. This device avoids the problems of poor micro-mixing and differences in light and heavy powders inherent in convection mixers, and solves the drawbacks of forced shear mixers where dead corners appear at the bottom and materials are not fully mixed due to the non-rotating mixing cylinder. It can significantly improve the uniformity of pharmaceutical raw material powder mixing, ensure accurate dosage and stable efficacy of each component in the drug, thereby improving drug quality and safety, and providing a more reliable and efficient mixing solution for pharmaceutical manufacturing and processing.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical production technology, specifically to a raw material addition device for pharmaceutical production and processing. Background Technology

[0002] In the pharmaceutical manufacturing and processing field, mixing pharmaceutical raw material powders is a crucial process. The degree of uniform mixing of pharmaceutical raw material powders directly affects the quality, efficacy, and safety of the final drug. During the mixing process, it is necessary to ensure that each component of the pharmaceutical raw material powders can be fully and uniformly dispersed to ensure accurate dosage and stable efficacy of the active ingredients in the drug. If the mixing is uneven, it may result in the content of some components in the drug being too high or too low, thereby affecting the therapeutic effect of the drug and even causing adverse reactions, posing a potential threat to the health of patients.

[0003] In existing technologies, convection mixers or forced shear mixers are commonly used for mixing pharmaceutical raw material powders. Convection mixers mainly include V-type convection mixers, three-dimensional convection mixers, and double-cone convection mixers. The working principle of these mixers is to use the specific shape and movement of the container to make the material continuously roll and convect within the container, thereby achieving mixing. Their advantage is that they can achieve convection mixing without dead angles on a macroscopic scale, allowing the material to be fully turned over and contacted over a large area. However, these mixers have significant shortcomings in microscopic mixing. At the microscopic level, the mixing effect of the material is not ideal, and it is difficult to achieve a highly uniform mixing state. In addition, due to the difference in density of different materials, light and heavy powders will separate during the convection mixing process. That is, materials with higher density and materials with lower density are difficult to distribute evenly during the mixing process, which further affects the uniformity of the mixing.

[0004] Forced shear mixers mainly include horizontal ribbon forced shear mixers and vertical double-spiral forced shear mixers. These mixers rely on the rotation of the ribbon inside the barrel to generate strong shearing and flow forces, enabling materials to be mixed in a short time. The rotation of the ribbon can forcefully stir and shear the materials, effectively promoting the mixing between materials. However, this type of mixer has a fatal flaw: the mixing barrel does not rotate. Because the mixing barrel is fixed, dead corners are easily formed at the bottom of the mixer during the mixing process. The materials in these dead corner areas are difficult to participate in the mixing process, which may cause one or more materials added to accumulate at the bottom and fail to mix fully with other materials, thus affecting the overall uniformity of the mixing.

[0005] In summary, existing raw material addition devices for pharmaceutical production and processing, whether convection mixers or forced shear mixers, have obvious defects. Although convection mixers can achieve macroscopic mixing without dead corners, they perform poorly in microscopic mixing and the difference between light and heavy powders. Although forced shear mixers can mix materials quickly, the dead corner problem at the bottom of the mixing cylinder seriously affects the uniformity of mixing. Summary of the Invention

[0006] The purpose of this invention is to address the shortcomings of poor mixing effects in existing technologies by proposing a raw material addition device for pharmaceutical production and processing.

[0007] To achieve the above objectives, the present invention provides the following technical solution: a raw material addition device for pharmaceutical production and processing, comprising: a main frame, a rotating frame, a first rotating cavity, a second rotating cavity, a first bevel gear, a rotating rod, a second bevel gear, a shearing mechanism, a striking mechanism, a motor, a first connecting rod, a first pulley, a second pulley, a first belt, a mixing tank, a tank lid, a buckle, a gear ring, and gears. The rear end of the rotating frame is rotatably mounted on the front middle of the main frame via a bearing, and the rear end of the rotating frame rotatably extends beyond the rear of the main frame. The top of the front side of the rotating frame is open. A first rotating cavity is provided, and a second rotating cavity is formed in the middle of the front side of the rotating frame; a first bevel gear is disposed in the middle of the front side of the main frame, and the first bevel gear is rotatably sleeved on the rear side of the outer wall of the rotating frame via a bearing, the center of the first bevel gear and the center of the rear side of the outer wall of the rotating frame being the same; a rotating rod is rotatably disposed in the rear side of the top of the rotating frame via a bearing, the bottom end of the rotating rod rotatably extending out of the bottom end of the rotating frame, and the outer wall of the rotating rod rotatably penetrating the inner cavity of the first and second rotating cavities; the second bevel gear is sleeved on the rotating frame. The second bevel gear is located in the inner cavity of the second rotating chamber and meshes with the first bevel gear. The shearing mechanism is located at the bottom front end of the rotating frame. The striking mechanism is located at the top front end of the rotating frame. The motor screw is connected to the rear top of the main frame. One end of the first connecting rod is locked to the output end of the motor via a coupling, and the other end of the first connecting rod is rotatably located on the rear side of the main frame via a bearing. The first pulley is sleeved on the outer wall of the first connecting rod and locked. The pulley is fitted onto the rear side of the outer wall of the rotating frame and locked; the two ends of the first belt are respectively fitted onto the outer walls of the first pulley and the second pulley; the middle of the outer wall of the mixing barrel is fixedly inserted into the top of the inner cavity of the rotating frame; there are several buckles, which are equidistantly arranged on the top of the outer wall of the mixing barrel along the circumference; the barrel lid is detachably mounted on the top of the mixing barrel via buckles; the toothed ring is fitted onto the top of the outer wall of the mixing barrel and locked; the gear is fitted onto the top of the outer wall of the rotating rod and locked by a set screw, and the gear and the toothed ring mesh.

[0008] Furthermore, in order to apply a transverse shearing force to the pharmaceutical raw material powder in the inner cavity of the mixing tank, the shearing mechanism includes: a third pulley, a worm, a fourth pulley, a second belt, a telescopic rod, a slider, a helical ribbon, a sliding groove, a collar, a sliding column, a second connecting rod, and a worm wheel; the third pulley is sleeved on the bottom end of the outer wall of the rotating rod and locked; the worm is rotatably disposed on the front side of the bottom end of the inner cavity of the rotating frame through a bearing, and the bottom end of the worm extends rotatably out of the bottom end of the rotating frame; the fourth pulley is sleeved on the bottom end of the outer wall of the worm and locked; the two ends of the second belt are respectively sleeved on the outer walls of the third pulley and the fourth pulley; the telescopic rod is disposed at the top end of the worm; the helical ribbon is slidably sleeved on the outer wall of the telescopic rod, and the top end of the helical ribbon is rotatably and slidably adapted to extend into the inner cavity of the mixing tank; the collar is rotatably sleeved on the bottom end of the outer wall of the helical ribbon through a bearing; there are two sliding columns, and the two sliding columns are respectively disposed on the left and right sides of the outer wall of the collar.

[0009] Furthermore, in order to apply longitudinal shearing force to the pharmaceutical raw material powder in the inner cavity of the mixing tank, the shearing mechanism also includes: a swing frame, a moving groove, a connecting rod, and an eccentric wheel. The rear end of the swing frame is rotatably mounted on the front bottom of the rotating frame via a pin. The left and right front sides of the swing frame are each provided with a moving groove communicating with its inner cavity along the front-rear direction. The collar is embedded in the front side of the inner cavity of the swing frame. The two sliding columns are respectively slidably fitted and inserted into the front side of the inner cavity of the two moving grooves. The second connecting rod is rotatably mounted on the front bottom of the rotating frame via a bearing. The left and right ends of the second connecting rod rotatably extend to the left and right sides of the rotating frame, respectively; the worm gear is sleeved on the middle of the outer wall of the second connecting rod and locked by a set screw, and the worm gear and the worm mesh; there are two eccentric wheels, which are respectively sleeved on the left and right sides of the outer wall of the second connecting rod and locked by a set screw; there are two connecting rods, the bottom ends of which are rotatably sleeved on the outer walls of the two eccentric wheels by bearings, and the top ends of which are rotatably set on the middle of the left and right sides of the swing frame by pins.

[0010] Furthermore, the inner wall of the spiral ribbon is provided with several sliding grooves at equal intervals from top to bottom along the circumference, and the outer wall of the telescopic rod is provided with several sliders at equal intervals along the circumference. The sliders are respectively slidably adapted to be inserted into the inner cavity of the several sliding grooves.

[0011] Furthermore, in order to drive the rubber striking rod to swing, the striking mechanism includes: a first sprocket, a third connecting rod, a second sprocket, a chain, and a cam. The first sprocket is sleeved on the top of the outer wall of the rotating rod and locked by a set screw. The first sprocket is located in the inner cavity of the first rotating chamber. There are two third connecting rods, and the upper and lower ends of the two third connecting rods are rotatably disposed on the upper and lower sides and left and right ends of the rotating frame respectively through bearings. The second sprocket is sleeved on the outer wall of the third connecting rod and locked by a set screw. The chain is sleeved on the outer walls of the first sprocket and the two second sprockets. The cam is sleeved on the top of the outer wall of the third connecting rod and locked.

[0012] Furthermore, in order to strike the outer wall of the mixing tank, the striking mechanism also includes: a rubber striking rod and a spring. There are two rubber striking rods, one end of which is rotatably mounted on the top of the left and right sides of the rotating frame via pins. The outer wall of the rubber striking rod is in contact with the outer wall of the cam. One end of the spring is engaged with the outer wall of the rubber striking rod, and the other end of the spring is engaged with the outer wall of the rotating frame.

[0013] Furthermore, the distance from the bottom of the rotating frame to the rear side of the outer wall of the rotating frame is greater than the distance from the rear side of the outer wall of the rotating frame to the top of the bucket lid.

[0014] Compared with the prior art, the beneficial effects of the present invention are:

[0015] (1) The present invention can hold the pharmaceutical raw material powder to be mixed in the mixing barrel. The motor can drive the rotating frame to rotate through the cooperation between the first connecting rod, the first pulley, the second pulley and the first belt. The rotating frame can drive the mixing barrel to rotate around the rear side of the outer wall of the rotating frame. While the rotating frame is rotating, it will drive the second bevel gear to roll along the outer wall of the first bevel gear. The cooperation between the first bevel gear and the second bevel gear can drive the rotating rod to rotate. The rotation of the rotating rod can drive the gear to rotate. The cooperation between the gear and the gear ring can cause the mixing barrel to rotate, thereby achieving macroscopic mixing without dead angles.

[0016] (2) In this invention, the rotation of the rotating rod can drive the worm to rotate through the third pulley, the fourth pulley, and the second belt. The rotation of the worm can drive the telescopic rod and the worm wheel to rotate. The rotation of the telescopic rod can drive the screw ribbon to rotate through the cooperation between the slider and the slide groove, thereby applying a transverse shearing force to the pharmaceutical raw material powder in the inner cavity of the mixing barrel. The rotation of the worm wheel can drive the eccentric wheel to rotate through the second connecting rod. The rotation of the eccentric wheel can drive the swing frame to swing up and down through the connecting rod. The swing frame swings up and down through the sliding column and the collar to drive the screw ribbon to move up and down along the outer wall of the telescopic rod. At the same time, it causes the sliding column to slide back and forth along the inner cavity of the moving groove, thereby applying a longitudinal shearing force to the pharmaceutical raw material powder in the inner cavity of the mixing barrel.

[0017] (3) The present invention can drive the first sprocket to rotate by rotating the rotating rod, and then drive the third connecting rod to rotate by the cooperation between the chain and the second sprocket. The rotation of the third connecting rod can drive the cam to rotate. The rotation of the cam can push the rubber striking rod to swing outward and stretch the spring to undergo elastic deformation. As the cam rotates, when the rubber striking rod and the cam separate, the rubber striking rod can be pulled inward to swing back to the initial position under the elastic force of the spring. Thus, the rubber striking rod can be used to strike the outer wall of the mixing barrel, causing the outer wall of the mixing barrel to vibrate. This can prevent the pharmaceutical raw material powder from adhering to the inner wall of the mixing barrel due to static electricity and other reasons, thus affecting the mixing effect.

[0018] (4) This device avoids the problems of poor micro-mixing and differences between light and heavy powders in convection mixers, and solves the drawbacks of dead corners and insufficient material mixing caused by the non-rotation of the mixing cylinder in forced shear mixers. It can significantly improve the uniformity of pharmaceutical raw material powder mixing, ensure accurate dosage of each component in the drug and stable efficacy, thereby improving drug quality and safety, and providing a more reliable and efficient mixing solution for pharmaceutical production and processing. Attached Figure Description

[0019] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the structure of the present invention;

[0021] Figure 2 This is a schematic diagram of the motor structure;

[0022] Figure 3 This is a right view of the present invention;

[0023] Figure 4 This is an exploded view of the present invention;

[0024] Figure 5 This is a schematic diagram of the rotating frame.

[0025] Figure 6 Exploded view of the rotating frame;

[0026] Figure 7 This is a schematic diagram of the structure of a spiral ribbon;

[0027] Figure 8 for Figure 6 Enlarged view of point A;

[0028] Figure 9 for Figure 6 Enlarged view of point B;

[0029] Figure 10 for Figure 6 Enlarged view of point C;

[0030] Figure 11 for Figure 6 Enlarged view of point D;

[0031] Figure 12 for Figure 7 Enlarged view of point E;

[0032] Figure 13 for Figure 6 Enlarged view of point F.

[0033] The components represented by each number in the diagram are listed below: 1. Main frame; 2. Rotating frame; 3. First rotating cavity; 4. Second rotating cavity; 5. First bevel gear; 6. Rotating rod; 7. Second bevel gear; 8. Shearing mechanism; 81. Third pulley; 82. Worm gear; 83. Fourth pulley; 84. Second belt; 85. Telescopic rod; 86. Slider; 87. Screw ribbon; 88. Slide groove; 89. Collar; 810. Sliding column; 811. Second connecting rod; 812. Worm gear; 813. Swing frame; 814. Moving groove; 815. Connecting rod; 816. Eccentric wheel; 9. Striking mechanism; 91. First sprocket; 92. Third connecting rod; 93. Second sprocket; 94. Chain; 95. Cam; 96. Rubber striking rod; 97. Spring; 10. Motor; 11. First connecting rod; 12. First pulley; 13. Second pulley; 14. First belt; 15. Mixing tank; 16. Tank lid; 17. Fastener; 18. Gear ring; 19. Gear. Detailed Implementation

[0034] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0035] In the description of this invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0036] Reference Figures 1-13A raw material addition device for pharmaceutical production and processing includes: a main frame 1, a rotating frame 2, a first rotating cavity 3, a second rotating cavity 4, a first bevel gear 5, a rotating rod 6, a second bevel gear 7, a shearing mechanism 8, a striking mechanism 9, a motor 10, a first connecting rod 11, a first pulley 12, a second pulley 13, a first belt 14, a mixing tank 15, a tank lid 16, a buckle 17, a gear ring 18, and a gear 19. The rear end of the rotating frame 2 is rotatably mounted on the front middle of the main frame 1 via a bearing, and the rear end of the rotating frame 2 extends rotatably beyond the rear of the main frame 1. The first rotating cavity 3 is formed at the top of the front side of the rotating frame 2, and the second rotating cavity 4 is formed at the middle of the front side of the rotating frame 2. The rotating frame 2 is used to mount the mixing tank 15 and drive the mixing tank 15 into the mixing tank. The rotation is reversed. The first bevel gear 5 is located at the front center of the main frame 1. The first bevel gear 5 is rotatably sleeved on the rear side of the outer wall of the rotating frame 2 via a bearing. The center of the first bevel gear 5 is the same as the center of the rear side of the outer wall of the rotating frame 2. The rotating rod 6 is rotatably located at the rear top of the rotating frame 2 via a bearing. The bottom end of the rotating rod 6 rotatably extends out of the bottom end of the rotating frame 2. The outer wall of the rotating rod 6 rotatably passes through the inner cavity of the first rotating cavity 3 and the second rotating cavity 4. The second bevel gear 7 is sleeved on the middle of the outer wall of the rotating rod 6 and locked by a set screw. The second bevel gear 7 is located in the inner cavity of the second rotating cavity 4. The second bevel gear 7 and the first bevel gear 5 mesh. When the rotating frame 2 rotates, it will cause the second bevel gear 7 to move along the first bevel gear 5. The outer wall rolls, causing the second bevel gear 7 to drive the rotating rod 6 to rotate. The shearing mechanism 8 is located at the bottom front of the rotating frame 2. The shearing mechanism 8 is used to apply transverse and longitudinal shearing forces to the pharmaceutical raw material powder in the inner cavity of the mixing barrel 15. The striking mechanism 9 is located at the top front of the rotating frame 2. The striking mechanism 9 is used to strike the outer wall of the mixing barrel 15, causing the outer wall of the mixing barrel 15 to vibrate. The motor 10 is screwed to the rear top of the main frame 1. The motor 10 is existing technology. The motor 10 is a servo motor and is connected to a servo controller. It will not be described in detail here. The motor 10 is used to drive the rotating frame 2 to rotate through the first pulley 12, the second pulley 13 and the first belt 14. One end of the first connecting rod 11 is connected to the connecting rod 14. The shaft is locked to the output end of the motor 10. The other end of the first connecting rod 11 is rotatably mounted on the rear side of the main frame 1 via a bearing. The first pulley 12 is sleeved on the outer wall of the first connecting rod 11 and locked. The second pulley 13 is sleeved on the rear side of the outer wall of the rotating frame 2 and locked. The two ends of the first belt 14 are respectively sleeved on the outer walls of the first pulley 12 and the second pulley 13. The middle of the outer wall of the mixing barrel 15 is fixedly inserted into the top of the inner cavity of the rotating frame 2. The mixing barrel 15 is used to hold pharmaceutical raw material powder. There are several fasteners 17, which are equidistantly arranged on the top of the outer wall of the mixing barrel 15 along the circumference. The fasteners 17 are existing technology and will not be described in detail here. The fasteners 17 are used to fix the barrel lid 16 to the top of the mixing barrel 15.The lid 16 is detachably mounted on the top of the mixing drum 15 via a snap fastener 17. The lid 16 ensures the sealing of the inner cavity of the mixing drum 15. The distance from the bottom of the rotating frame 2 to the rear side of its outer wall is greater than the distance from the rear side of the outer wall of the rotating frame 2 to the top of the lid 16, ensuring that the rotating frame 2 can smoothly rotate the mixing drum 15. The gear ring 18 is fitted onto the top of the outer wall of the mixing drum 15 and locked. The gear ring 18 drives the mixing drum 15 to rotate. The gear 19 is fitted onto the top of the outer wall of the rotating rod 6 and locked by a set screw. The gear 19 meshes with the gear ring 18; rotation of the gear 19 engages with the gear ring 18 to cause the mixing drum 15 to rotate.

[0037] Specifically, the shearing mechanism 8 includes: a third pulley 81, a worm gear 82, a fourth pulley 83, a second belt 84, a telescopic rod 85, a slider 86, a threaded belt 87, a sliding groove 88, a collar 89, a sliding column 810, a second connecting rod 811, a worm wheel 812, a swing frame 813, a moving groove 814, a connecting rod 815, and an eccentric wheel 816. The third pulley 81 is sleeved on the bottom end of the outer wall of the rotating rod 6 and locked. The worm gear 82 is rotatably disposed on the front side of the bottom end of the inner cavity of the rotating frame 2 through a bearing. The bottom end of the worm gear 82 rotatably extends out of the bottom end of the rotating frame 2. The fourth pulley 83 is sleeved on the bottom end of the outer wall of the worm gear 82 and locked. The two ends of the second belt 84 are respectively sleeved on the outer walls of the third pulley 81 and the fourth pulley 83, extending... The telescopic rod 85 is located at the top of the worm gear 82. Several sliders 86 are equidistantly arranged on the outer wall of the telescopic rod 85. The cooperation between the sliders 86 and the grooves 88 causes the screw ribbon 87 to rotate with the telescopic rod 85. The screw ribbon 87 is slidably sleeved on the outer wall of the telescopic rod 85. The top of the screw ribbon 87 is rotatably and slidably extended into the inner cavity of the mixing tank 15. Several grooves 88 are equidistantly arranged from top to bottom on the inner wall of the screw ribbon 87. Several sliders 86 are slidably inserted into the inner cavities of the grooves 88. The screw ribbon 87 applies shear force to the pharmaceutical raw material powder in the inner cavity of the mixing tank 15. A collar 89 is rotatably sleeved on the outer wall of the screw ribbon 87 via a bearing. At the bottom, the collar 89 drives the screw ribbon 87 to reciprocate up and down. There are two sliding pins 810, respectively located on the left and right sides of the outer wall of the collar 89. The rear end of the swing frame 813 is rotatably mounted on the front bottom of the rotating frame 2 via a pin. The front of both sides of the swing frame 813 has a moving groove 814 communicating with its inner cavity along the front-back direction. The collar 89 is embedded in the front of the inner cavity of the swing frame 813. The two sliding pins 810 are slidably fitted into the front of the inner cavities of the two moving grooves 814. The swing frame 813 reciprocates up and down, driven by the sliding pins 810, causing the collar 89 to reciprocate up and down. The second connecting rod 811 is rotatably mounted on the front bottom of the rotating frame 2 via a bearing. The left and right ends of the second connecting rod 811 extend rotatably to the left and right sides of the rotating frame 2. The worm gear 812 is sleeved on the middle of the outer wall of the second connecting rod 811 and locked by a set screw. The worm gear 812 and the worm 82 mesh with each other. There are two eccentric wheels 816, which are respectively sleeved on the left and right sides of the outer wall of the second connecting rod 811 and locked by a set screw. There are two connecting rods 815, and the bottom ends of the two connecting rods 815 are rotatably sleeved on the outer walls of the two eccentric wheels 816 through bearings. The top ends of the two connecting rods 815 are rotatably set on the middle of the left and right sides of the swing frame 813 through pins. When the eccentric wheel 816 rotates, the connecting rod 815 can drive the swing frame 813 to swing up and down.

[0038] Specifically, the striking mechanism 9 includes: a first sprocket 91, a third connecting rod 92, a second sprocket 93, a chain 94, a cam 95, a rubber striking rod 96, and a spring 97. The first sprocket 91 is sleeved on the top of the outer wall of the rotating rod 6 and locked by a set screw. The first sprocket 91 is located in the inner cavity of the first rotating cavity 3. There are two third connecting rods 92, and their upper and lower ends are rotatably mounted on the upper and lower sides and left and right ends of the rotating frame 2 respectively via bearings. The second sprocket 93 is sleeved on the outer wall of the third connecting rod 92 and locked by a set screw. The chain 94 is sleeved on the outer walls of the first sprocket 91 and the two second sprockets 93. The cam 95 is sleeved on the top of the outer wall of the third connecting rod 92 and locked. When the cam 95 rotates, it can push the rubber striking rod 96. The 6 swings outward. There are two rubber striking rods 96. One end of each rubber striking rod 96 is rotatably mounted on the top of the left and right sides of the rotating frame 2 via pins. The outer wall of the rubber striking rod 96 is in contact with the outer wall of the cam 95. The rubber striking rod 96 is used to strike the outer wall of the mixing barrel 15, causing the mixing barrel 15 to vibrate, thereby shaking off the pharmaceutical raw material powder that is adhered to the inner wall of the mixing barrel 15 due to static electricity or other reasons. One end of the spring 97 is attached to the outer wall of the rubber striking rod 96, and the other end of the spring 97 is attached to the outer wall of the rotating frame 2. The spring 97 is a rotary spring. After being squeezed or stretched by external force, it undergoes elastic deformation and returns to its initial state after the external force is removed. The spring 97 is used here to pull the rubber striking rod 96 back to its initial position.

[0039] Step 1: When using this invention, open the buckle 17, remove the lid 16, pour the pharmaceutical raw material powder to be mixed into the inner cavity of the mixing bucket 15, close the lid 16, and lock it with the buckle 17. Start the motor 10. The rotation of the output end of the motor 10 can drive the first pulley 12 to rotate through the first connecting rod 11, and then drive the rotating frame 2 to rotate through the second pulley 13 via the first belt 14. The rotation of the rotating frame 2 can cause the mixing bucket 15 to rotate around the rear side of the outer wall of the rotating frame 2, while simultaneously causing the second... The bevel gear 7 rolls along the outer wall of the first bevel gear 5. When the second bevel gear 7 rolls along the outer wall of the first bevel gear 5, it can cause the second bevel gear 7 to drive the rotating rod 6 to rotate. The rotation of the rotating rod 6 can drive the gear 19, the third pulley 81 and the first sprocket 91 to rotate. The rotation of the gear 19 can cooperate with the gear ring 18 to cause the mixing barrel 15 to rotate. Thus, the mixing barrel 15 rotates while flipping, which can achieve macroscopic mixing of the pharmaceutical raw material powder in the inner cavity of the mixing barrel 15 without dead angles.

[0040] Step 2: When the first sprocket 91 rotates, the chain 94 can cause the second sprocket 93 to drive the third connecting rod 92 to rotate. The rotation of the third connecting rod 92 can drive the cam 95 to rotate. The rotation of the cam 95 can push the rubber striking rod 96 to swing outward and stretch the spring 97 to undergo elastic deformation until the rubber striking rod 96 and the cam 95 separate. Under the elastic force of the spring 97, the rubber striking rod 96 can be pulled to swing inward to the initial position. Then, the rubber striking rod 96 can be used to strike the outer wall of the mixing barrel 15, causing the outer wall of the mixing barrel 15 to vibrate. This can shake off the pharmaceutical raw material powder that is adhered to the inner wall of the mixing barrel 15 due to static electricity or other reasons, thereby enhancing the mixing effect.

[0041] Step 3: The rotation of the third pulley 81 drives the worm gear 82 to rotate via the second belt 84 and the fourth pulley 83. The rotation of the worm gear 82 drives the telescopic rod 85 and the worm wheel 812 to rotate. The rotation of the telescopic rod 85 drives the screw ribbon 87 to rotate via the cooperation between the slider 86 and the groove 88. Thus, the rotating screw ribbon 87 can apply a transverse shearing force to the pharmaceutical raw material powder in the inner cavity of the mixing tank 15. The rotation of the worm wheel 812 drives the eccentric wheel 816 to rotate via the second connecting rod 811. The rotation of the eccentric wheel 816 drives the swing frame 813 to rotate via the connecting rod 815. The reciprocating motion of the screw belt 87, through the cooperation between the reciprocating swing frame 813 and the sliding column 810, drives the screw belt 87 to reciprocate up and down. At the same time, the sliding column 810 reciprocates back and forth along the inner cavity of the moving groove 814. Thus, the reciprocating screw belt 87 applies a longitudinal shearing force to the pharmaceutical raw material powder in the inner cavity of the mixing tank 15, achieving micro-mixing of the pharmaceutical raw material powder in the inner cavity of the mixing tank 15. After mixing is completed, the motor 10 is turned off, the latch 17 is opened, the tank cover 16 is removed, and the mixed pharmaceutical raw material powder in the inner cavity of the mixing tank 15 is poured out.

[0042] This device avoids the problems of poor micro-mixing and differences between light and heavy powders in convection mixers, and solves the drawbacks of forced shear mixers, such as dead corners at the bottom and insufficient material mixing due to the non-rotation of the mixing cylinder. It can significantly improve the uniformity of pharmaceutical raw material powder mixing, ensure accurate dosage of each component in the drug and stable efficacy, thereby improving drug quality and safety, and providing a more reliable and efficient mixing solution for pharmaceutical production and processing.

[0043] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to specific implementations. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A raw material addition device for pharmaceutical production and processing, characterized in that, include: Main frame (1); The rear end of the rotating frame (2) is rotatably disposed in the middle of the front side of the main frame (1) via a bearing. The rear end of the rotating frame (2) extends rotatably out of the rear side of the main frame (1). A first rotating cavity (3) is provided on the top of the front side of the rotating frame (2), and a second rotating cavity (4) is provided in the middle of the front side of the rotating frame (2). The first bevel gear (5) is located in the middle of the front side of the main frame (1). The first bevel gear (5) is rotatably sleeved on the rear side of the outer wall of the rotating frame (2) through a bearing. The center of the first bevel gear (5) is the same as the center of the rear side of the outer wall of the rotating frame (2). Rotating rod (6), the rotating rod (6) is rotatably mounted on the rear side of the top of the rotating frame (2) via a bearing, the bottom end of the rotating rod (6) extends rotatably out of the bottom end of the rotating frame (2), and the outer wall of the rotating rod (6) rotatably penetrates the inner cavity of the first rotating cavity (3) and the second rotating cavity (4). The second bevel gear (7) is sleeved on the middle of the outer wall of the rotating rod (6) and locked by a set screw. The second bevel gear (7) is located in the inner cavity of the second rotating cavity (4). The second bevel gear (7) meshes with the first bevel gear (5). A shearing mechanism (8) is provided at the bottom front end of the rotating frame (2); A striking mechanism (9) is provided on the top front side of the rotating frame (2); The mixing barrel (15) is fixedly inserted into the top of the inner cavity of the rotating frame (2) at the middle of its outer wall; The shearing mechanism (8) includes: The third pulley (81) is sleeved on the bottom of the outer wall of the rotating rod (6) and locked. The worm (82) is rotatably disposed on the front side of the bottom end of the inner cavity of the rotating frame (2) via a bearing, and the bottom end of the worm (82) extends rotatably out of the bottom end of the rotating frame (2). The fourth pulley (83) is sleeved on the bottom of the outer wall of the worm (82) and locked. The second belt (84) has its two ends respectively fitted onto the outer walls of the third pulley (81) and the fourth pulley (83); Telescopic rod (85), the telescopic rod (85) is disposed at the top of the worm gear (82); A spiral ribbon (87) is slidably sleeved on the outer wall of the telescopic rod (85). The top end of the spiral ribbon (87) is rotatably and slidably adapted to extend into the inner cavity of the mixing tank (15). The inner wall of the spiral ribbon (87) is provided with several sliding grooves (88) equidistantly from top to bottom along the circumferential direction. The outer wall of the telescopic rod (85) is provided with several sliding blocks (86) equidistantly along the circumferential direction. The several sliding blocks (86) are respectively slidably adapted to be inserted into the inner cavity of the several sliding grooves (88). A collar (89) is rotatably sleeved on the bottom of the outer wall of the threaded ribbon (87) via a bearing; Sliding pins (810), there are two sliding pins (810), and the two sliding pins (810) are respectively disposed on the left and right sides of the outer wall of the collar (89); The swing frame (813) is rotatably mounted on the front bottom of the rotating frame (2) via a pin. The swing frame (813) has a moving groove (814) connected to its inner cavity on both the left and right front sides along the front-back direction. The collar (89) is embedded in the front side of the inner cavity of the swing frame (813). The two sliding columns (810) are respectively slidably fitted and inserted into the front side of the inner cavity of the two moving grooves (814). The second connecting rod (811) is rotatably mounted on the front bottom of the rotating frame (2) via a bearing, and the left and right ends of the second connecting rod (811) extend rotatably out of the left and right sides of the rotating frame (2). Worm wheel (812), the worm wheel (812) is sleeved on the middle of the outer wall of the second connecting rod (811) and locked by a set screw, the worm wheel (812) and the worm (82) mesh with each other; Eccentric wheel (816), there are two eccentric wheels (816), the two eccentric wheels (816) are respectively sleeved on the left and right sides of the outer wall of the second connecting rod (811) and locked by set screw; There are two connecting rods (815). The bottom ends of the two connecting rods (815) are rotatably sleeved on the outer walls of two eccentric wheels (816) through bearings. The top ends of the two connecting rods (815) are rotatably set in the middle of the left and right sides of the swing frame (813) through pins.

2. The raw material addition device for pharmaceutical production and processing according to claim 1, characterized in that, The pharmaceutical raw material addition device also includes: Fasteners (17), the number of fasteners (17) is several, and several fasteners (17) are respectively arranged at equal intervals along the circumference on the top of the outer wall of the mixing barrel (15); A bucket lid (16) is detachably mounted on the top of the mixing bucket (15) via a buckle (17).

3. The raw material addition device for pharmaceutical production and processing according to claim 2, characterized in that, The pharmaceutical raw material addition device also includes: Motor (10), which is screwed to the rear top of the main frame (1); The first connecting rod (11) has one end locked to the output end of the motor (10) by a coupling, and the other end of the first connecting rod (11) is rotatably set on the rear side of the main frame (1) by a bearing. The first pulley (12) is sleeved on the outer wall of the first connecting rod (11) and locked. The second pulley (13) is sleeved on the rear side of the outer wall of the rotating frame (2) and locked. The first belt (14) has its two ends respectively fitted onto the outer walls of the first pulley (12) and the second pulley (13); A toothed ring (18) is fitted onto the top of the outer wall of the mixing barrel (15) and locked in place; Gear (19) is sleeved on the top of the outer wall of the rotating rod (6) and locked by a set screw. Gear (19) meshes with gear ring (18).

4. The raw material addition device for pharmaceutical production and processing according to claim 3, characterized in that, The striking mechanism (9) includes: The first sprocket (91) is sleeved on the top of the outer wall of the rotating rod (6) and locked by a set screw. The first sprocket (91) is located in the inner cavity of the first rotating cavity (3). The third connecting rod (92) has two parts, and the upper and lower ends of the two third connecting rods (92) are rotatably set on the upper and lower sides and left and right ends of the rotating frame (2) respectively through bearings; The second sprocket (93) is sleeved on the outer wall of the third connecting rod (92) and locked by a set screw; A chain (94) is fitted onto the outer wall of a first sprocket (91) and two second sprockets (93); Cam (95) is sleeved on the top of the outer wall of the third connecting rod (92) and locked.

5. The raw material addition device for pharmaceutical production and processing according to claim 4, characterized in that, The striking mechanism (9) further includes: Two rubber striking rods (96) are provided. One end of each rubber striking rod (96) is rotatably mounted on the top of the left and right sides of the rotating frame (2) via a pin. The outer wall of the rubber striking rod (96) is in contact with the outer wall of the cam (95). A spring (97) is attached to the outer wall of a rubber striking rod (96) at one end and to the outer wall of a rotating frame (2) at the other end.

6. The raw material addition device for pharmaceutical production and processing according to claim 5, characterized in that, The distance from the bottom of the rotating frame (2) to the rear side of the outer wall of the rotating frame (2) is greater than the distance from the rear side of the outer wall of the rotating frame (2) to the top of the bucket lid (16).

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