Miao medicine traumatology liquid for reducing swelling and easing pain at fracture and preparation method of Miao medicine traumatology liquid

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a Miao medicine traumatology liquid for relieving swelling and pain of fracture and a preparation method thereof.The Miao medicine traumatology liquid is prepared from, by weight, 10-20 parts of callicarpa macrophylla, 10-20 parts of sargentgloryvine stem, 15-20 parts of honeysuckle, 10-15 parts of polygonum cuspidatum, 10-15 parts of golden cypress and 15-20 parts of radix rubiae. , 10-15 parts of turmeric, 10-20 parts of motherwort, 6-8 parts of frankincense, 6-8 parts of myrrh and 10-15 parts of cape jasmine. In the Miao medicine traumatology liquid provided by the invention, the callicarpa macrophylla can dissipate blood stasis, stop bleeding and relieve swelling and pain, the polygonum cuspidatum can clear away heat and toxic materials, dissipate blood stasis and relieve pain, and the motherwort can clear away heat and toxic materials, activate blood and relieve swelling; lonicera japonica, golden cypress and cape jasmine have the effects of clearing away heat and toxic materials, purging fire and relieving pain, and serve as ministerial drugs together. Turmeric, frankincense and myrrh are used for removing blood stasis, promoting the circulation of qi and relieving swelling and pain, and are used as adjuvant drugs together; the traditional Chinese medicine composition has the remarkable effects of promoting blood circulation to remove blood stasis and relieving swelling and pain on the fracture part of a patient through combined use of all the medicines and simultaneous application of blood circulation and heat clearing.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a Miao medicine injury solution for reducing swelling and relieving pain at fractures and a preparation method thereof. Background Art

[0002] Fractures are common clinical injuries, and their treatment requires both reduction and fixation as well as local swelling and analgesia to promote callus formation and functional recovery. Traditional methods often use manual reduction combined with splint fixation, supplemented by topical medications to achieve optimal therapeutic effects. However, existing topical Chinese medicine compositions have the following limitations and insufficient efficacy: some formulas fail to synergize their blood circulation and blood stasis-removing and heat-clearing and detoxifying effects, resulting in slow swelling reduction and affecting the fracture healing process; safety issues: some drug combinations contain irritants that can easily induce adverse reactions such as skin allergies and tension blisters, reducing patient compliance.

[0003] Therefore, the existing technology still needs to be improved and developed. Summary of the Invention

[0004] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a Miao medicine traumatology liquid for reducing swelling and relieving pain at fracture sites and a preparation method thereof, aiming to solve the problems of poor swelling reduction effect and easy allergy of existing external application of Chinese medicine for fracture patients.

[0005] The technical solutions of the present invention are as follows:

[0006] A Miao medicine traumatology liquid for reducing swelling and relieving pain at fractures, wherein the Miao medicine traumatology liquid comprises, by weight: 10-20 parts of Callicarpa macrophylla, 10-20 parts of Sargentodoxae cyrtonema, 15-20 parts of honeysuckle, 10-15 parts of Polygonum cuspidatum, 10-15 parts of Phellodendron amurense, 15-20 parts of Rubia cordifolia, 10-15 parts of Curcuma longa, 10-20 parts of Leonurus japonicus, 6-8 parts of frankincense, 6-8 parts of myrrh, and 10-15 parts of Gardenia jasminoides.

[0007] The Miao medicine traumatology liquid for reducing swelling and relieving pain in fractures comprises, by weight: 15 parts of Callicarpa macrophylla, 15 parts of Sargentodoxae cyrtonema, 18 parts of honeysuckle, 12 parts of Polygonum cuspidatum, 12 parts of Phellodendron amurense, 18 parts of Rubia cordifolia, 12 parts of Curcuma longa, 15 parts of Leonurus japonicus, 7 parts of frankincense, 7 parts of myrrh, and 12 parts of Gardenia jasminoides.

[0008] The Miao medicine traumatology liquid for reducing swelling and relieving pain in fractures comprises, by weight: 10 parts of Callicarpa macrophylla, 10 parts of Sargentodoxae cyrtonema, 15 parts of honeysuckle, 10 parts of Polygonum cuspidatum, 10 parts of Phellodendron amurense, 15 parts of Rubia cordifolia, 10 parts of turmeric, 10 parts of Leonurus japonicus, 6 parts of frankincense, 6 parts of myrrh, and 10 parts of Gardenia jasminoides.

[0009] The Miao medicine traumatology liquid for reducing swelling and relieving pain in fractures comprises, by weight: 20 parts of Callicarpa macrophylla, 20 parts of Sargentodoxae cyrtonema, 20 parts of honeysuckle, 15 parts of Polygonum cuspidatum, 15 parts of Phellodendron amurense, 20 parts of Rubia cordifolia, 15 parts of turmeric, 20 parts of Leonurus japonicus, 8 parts of frankincense, 8 parts of myrrh, and 15 parts of Gardenia jasminoides.

[0010] A method for preparing a Miao medicine traumatic liquid for reducing swelling and relieving pain at a fracture as described in the present invention comprises the following steps:

[0011] Weigh the following medicinal materials by weight: Callicarpa grandiflora, Sargentodoxae spatholobi, honeysuckle, Polygonum cuspidatum, Phellodendron amurense, Rubia cordifolia, turmeric, motherwort, frankincense, myrrh, and gardenia;

[0012] The medicinal materials are added into a high-pressure decoction machine, and then common drinking water is added until it covers the surface of the medicinal materials by 3-5 cm. After soaking for 20-30 minutes, the medicinal liquid is first heated with high heat until it boils, and then simmered with low heat for 30-50 minutes. The filtered medicinal liquid is the Miao medicine trauma liquid used for reducing swelling and relieving pain in fractures.

[0013] The method for preparing the Miao medicine traumatology liquid for reducing swelling and relieving pain at fracture sites, wherein the Miao medicine traumatology liquid is a liquid for external use.

[0014] Beneficial effects: In the Miao medicine traumatology liquid provided by the present invention, Callicarpa rubra dissipates blood stasis and stops bleeding, reduces swelling and relieves pain, Polygonum cuspidatum clears away heat and detoxifies, dissipates blood stasis and relieves pain, and Leonurus japonicus clears heat and detoxifies, promotes blood circulation and relieves swelling, and the three are collectively the main medicines; Sanguisorba officinalis and Herba Achyranthis Bidentatae promote blood circulation and stop bleeding, resolve blood stasis and relieve swelling, Honeysuckle, Phellodendron amurense, and Gardenia jasminoides clear heat and detoxifies, purges fire and relieves pain, and are collectively the ministerial medicines; Turmeric, frankincense, and myrrh dissipate blood stasis and promote qi circulation, reduce swelling and relieve pain, and are collectively the adjuvant medicines; all the medicines are used together to promote blood circulation and clear away heat, and have significant effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain in patients with fractures. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 The present invention is a flow chart of a method for preparing a Miao medicine injury solution for reducing swelling and relieving pain at fracture sites. DETAILED DESCRIPTION

[0016] The present invention provides a Miao medicine traumatic solution for reducing swelling and relieving pain at a fracture site and a preparation method thereof. To make the purpose, technical solution, and effects of the present invention clearer and more specific, the present invention is further described in detail below. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0017] The invention provides a Miao medicine traumatology liquid for reducing swelling and relieving pain at a fracture. The Miao medicine traumatology liquid comprises, by weight, 10-20 parts of Callicarpa macrophylla, 10-20 parts of Sargentodoxae cyrtonema, 15-20 parts of honeysuckle, 10-15 parts of Polygonum cuspidatum, 10-15 parts of Phellodendron amurense, 15-20 parts of Rubia cordifolia, 10-15 parts of Curcuma longa, 10-20 parts of Leonurus japonicus, 6-8 parts of frankincense, 6-8 parts of myrrh, and 10-15 parts of Gardenia jasminoides.

[0018] In this embodiment, the Callicarpa macrophylla is the dried leaves or leafy young branches of the Verbenaceae plant Callicarpa macrophylla. It has a pungent, bitter, and neutral nature and enters the liver, lung, and stomach meridians. It has the effects of dispersing blood stasis, stopping bleeding, reducing swelling and relieving pain, and can treat epistaxis, hemoptysis, hematemesis, hematochezia, traumatic bleeding, and swelling and pain from falls. (See "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, New Century Fifth Edition). Modern pharmacology shows that Callicarpa macrophylla mainly contains flavonoids, phenylethanoid glycosides, steroids, phenolic acids, phenylpropanoids, and terpenes. A decoction of Callicarpa macrophylla can shorten the prothrombin time, activated partial thromboplastin activity time, thrombin time, fibrinogen content, plasma thromboxane, and 6-keto-prostaglandin. It exerts a hemostatic effect by activating the intrinsic and exogenous coagulation systems and regulating plasma thromboxane and 6-keto-prostaglandin levels. It also has analgesic, anti-inflammatory, antibacterial, antioxidant, and anti-tumor effects. (Chen Kecheng, Dai Hang, Li Jianhua, et al. Research progress of Callicarpa macrophylla and application of network pharmacology combined with molecular docking technology to predict its mechanism of action in the treatment of hemorrhagic diseases [J]. Zhuang and Yao Medicine Research, 2023, (03): 188-199+522-523.).

[0019] In this embodiment, the safflower vine is the dried stem of the safflower vine of the Akebia family. It is bitter and neutral in nature and enters the large intestine and liver meridians. It has the effects of clearing away heat and toxic substances, promoting blood circulation, and dispelling wind and relieving pain. It can treat abdominal pain caused by intestinal carbuncle, ulcers caused by heat and toxicity, amenorrhea caused by blood stasis, dysmenorrhea, swelling and pain caused by falls, and rheumatic pain. Modern pharmacology shows that safflower vine mainly contains the anthraquinones emodin, physcion, chrysophanol, triterpenes, lignans, sterols, and various phenols and phenolic glycosides. A decoction of this product has a strong inhibitory effect on Staphylococcus aureus and Group B Streptococcus, and also has a certain inhibitory effect on Escherichia coli, Staphylococcus albus, Coccus catarrhalis, Group A Streptococcus, and Pseudomonas aeruginosa. Its aqueous extract can inhibit platelet aggregation, increase coronary flow, inhibit thrombosis, increase plasma cAMP levels, improve the hypoxia tolerance of experimental animals, dilate coronary arteries, and reduce the size of myocardial infarction. (See "Chinese Materia Medica", edited by Zhong Gansheng, China Traditional Chinese Medicine Press, fifth edition in the new century).

[0020] In this embodiment, the honeysuckle is the dried buds or newly opened flowers of the plant Lonicera japonica of the Caprifoliaceae family. It is sweet and cold in nature and enters the lung, heart, and stomach meridians. It has the effects of clearing away heat and detoxifying, and dispersing wind-heat, and can treat carbuncles, furuncles, throat paralysis, erysipelas, wind-heat colds, fever caused by febrile diseases, and dysentery caused by heat toxins. Modern pharmacology shows that it mainly contains organic acids such as chlorogenic acid, isochlorogenic acid, and caffeic acid; flavonoids such as luteolin, honeysuckle, hyperoside, and quercetin; and volatile oils, iridoid glycosides, and triterpenoid saponins. The chlorogenic acid compounds and other ingredients contained in this product have a certain inhibitory effect on various pathogens such as Staphylococcus aureus, hemolytic Streptococcus, Shigella dysenteriae, and Vibrio cholerae. It also has certain anti-influenza virus and coxsackie virus effects. Its decoction, oral solution, and injection have varying degrees of antipyretic effect and significantly increase the phagocytic percentage and phagocytic index of mouse peritoneal macrophages. Chlorogenic acid compounds have a significant choleretic effect, and saponins have a hepatoprotective effect. The honeysuckle charcoal suspension has a significant hemostatic effect and cholesterol-lowering effect. It also has anti-fertility, central nervous system excitation, and gastric juice secretion-promoting effects. (See "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, New Century Fifth Edition).

[0021] In this embodiment, the polygonum cuspidatum is the dried rhizome and root of the Polygonum cuspidatum plant of the Polygonaceae family. It is bitter and slightly cold in nature and enters the liver, gallbladder, and lung meridians. It has the effects of promoting dampness and relieving jaundice, clearing heat and detoxifying, dispersing blood stasis and relieving pain, and resolving phlegm and relieving cough. It can treat damp-heat jaundice, stranguria, leucorrhea; carbuncles, boils, burns, snake bites; amenorrhea, masses, rheumatic pain, traumatic injuries, and coughs caused by lung heat. Furthermore, this product has a heat-clearing and laxative effect and is used for heat-induced constipation. Modern pharmacology shows that polygonum cuspidatum mainly contains free anthraquinones and anthraquinone glycosides: emodin, physcion, chrysophanol, physcion-8-O-β-D-glucoside, emodin-8-O-β-D-glucoside, 6-hydroxyaloe-emodin, etc.; and stilbene glycosides: polydatin, etc. It also contains polysaccharides and amino acids. This product has laxative, expectorant, antitussive, blood pressure-lowering, hemostatic, and analgesic effects. Its decoction has inhibitory effects on various bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa, and also on certain viruses. (See "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, New Century Fifth Edition).

[0022] In this embodiment, the Phellodendron chinense is the dried bark of the Rutaceae plant Phellodendron chinense or Phellodendron amurense. It is bitter in nature and cold in nature; it enters the kidney and bladder meridians. It has the effects of clearing away heat and dampness, purging fire and detoxifying, and removing bone steaming. It can treat damp-heat diarrhea, jaundice and dark urine, leucorrhea and itching, painful stranguria due to heat, beriberi and paralysis; bone steaming and fever, night sweats, spermatorrhea; sores, swelling and toxins, eczema and wet sores, etc. Modern pharmacology shows that it mainly contains various alkaloids such as berberine, magnolia alkaloids, phellodendronine, jaundice, and palmatine. In addition, it also contains bitter substances such as phellodendron lactone, phellodendronone, and phellodendron acid, as well as steroid components such as 7-dehydrostigmasterol, β-sitosterol, and campesterol. The alkaloids contained in this product, such as berberine, jatrorrhizine, and palmatine, have inhibitory effects on Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, Salmonella typhi, Mycobacterium tuberculosis, and hemolytic Streptococci. They also have strong inhibitory effects on skin pathogenic fungi such as Candida albicans, Epidermophyton floccosum, and Microsporum flocculentum. They also have inhibitory effects on influenza virus and hepatitis B surface antigen. Phellodendron chinense and the berberine it contains have significant anti-inflammatory and antiproliferative properties, as well as anti-ulcer and choleretic effects. Furthermore, it has antiarrhythmic, antihypertensive, sedative, hypoglycemic, and anti-gout effects. (See "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, 5th edition, New Century Edition).

[0023] In this example, the Rubia cordifolia is the dried root and rhizome of the Rubiaceae plant. It is bitter and cold in nature and enters the Liver Meridian. It has the effects of cooling blood, removing blood stasis, stopping bleeding, and promoting menstruation. It can treat hematemesis, epistaxis, metrorrhagia, traumatic bleeding, amenorrhea, rheumatic pain, and swelling and pain due to falls. Modern pharmacology shows that it mainly contains naphthoquinones such as rubiacin, rubiacin, and rubiacin diester; anthraquinones such as hydroxyrubiacin, rubiacin, and rubiacin; terpenes, polysaccharides, and cyclic peptide compounds. This product has significant blood coagulation and anti-inflammatory effects. Its warm infusion can shorten the recalcification time, prothrombin time, and kaolin partial thromboplastin time in rabbits. Rubia cordifolia charcoal has a stronger effect than that of Rubia cordifolia. Oral administration of an alcohol extract of Rubia cordifolia can inhibit carrageenan-induced paw swelling in rats and acetic acid-induced inflammatory exudate in mice. It also has anti-tumor and antioxidant effects. (See "Chinese Materia Medica", edited by Zhong Gansheng, China Traditional Chinese Medicine Press, fifth edition in the new century).

[0024] In this example, the turmeric is the dried rhizome of the ginger plant Curcuma longa (Zingiberaceae). It is pungent, bitter, and warm in nature and flavor, and enters the liver and spleen meridians. It has the effects of promoting blood circulation and qi, relieving menstruation and alleviating pain, and can treat qi stagnation and blood stasis, chest and flank pain, chest pain, dysmenorrhea, amenorrhea, masses, swelling and pain due to falls, and rheumatic pain in the shoulder and arms. Modern pharmacology shows that it primarily contains volatile oils such as turmeric ketones, curcumone, curcumol, borneol, camphor, and curcumin. Curcumin can inhibit platelet aggregation, reduce plasma viscosity and whole blood viscosity, and has anti-inflammatory, antioxidant, lipid-lowering, and antihypertensive properties. It also protects the gastric mucosa and liver cells, and has neuroprotective effects. Turmeric extracts, curcumin, and volatile oils can all promote bile secretion. Furthermore, turmeric powder and extracts have anti-pregnancy and anti-tumor effects (see "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, 5th edition, New Century).

[0025] In this embodiment, the motherwort herb is the fresh or dried aerial part of the Lamiaceae plant, Leonurus japonicus. It is bitter, pungent, and slightly cold in nature and flavor; it enters the liver, pericardium, and bladder meridians. It has the effects of promoting blood circulation and regulating menstruation, promoting diuresis and reducing swelling, and clearing away heat and detoxifying. It can treat stasis, irregular menstruation, dysmenorrhea, amenorrhea, lochia retention, edema, oliguria, traumatic injuries, sores, carbuncles, and swelling. Modern pharmacology shows that it mainly contains alkaloids such as leonurine, stachydrine, and leonuridine; it also contains diterpenes and volatile oils. Leonurus herb decoctions, ethanol extracts, and leonurine have a uterine stimulating effect and have certain anti-implantation and anti-early pregnancy effects in mice. Leonurus herb injection can protect against myocardial ischemia-reperfusion injury, inhibit platelet aggregation, and reduce blood viscosity. Leonurus herb crude extract can dilate blood vessels and have a temporary antihypertensive effect. Leonurine has a significant diuretic effect. (See "Chinese Materia Medica", edited by Zhong Gansheng, China Traditional Chinese Medicine Press, fifth edition in the new century).

[0026] In this embodiment, the frankincense is a resin exuded from the bark of the Boswellia serrata plant and similar plants in the Oleaceae family. It is pungent, bitter, and warm in nature and flavor, and enters the heart, liver, and spleen meridians. It has the effects of promoting blood circulation, alleviating pain, reducing swelling and promoting tissue regeneration, and is effective in treating injuries from falls, carbuncles, sores, qi stagnation and blood stasis, chest pain, epigastric pain, dysmenorrhea, amenorrhea, postpartum stasis, abdominal pain due to abdominal masses, rheumatic pain, and muscle spasms. Modern pharmacology shows that it primarily contains volatile oils such as octyl acetate, α-pinene, elemene, 1-octanol, and cineole; and resinous components such as free α,β-boswellic acid, amyl ketone, and frankincense resin hydrocarbons. Frankincense volatile oil and alcohol extracts have significant analgesic effects; frankincense extracts have strong anti-inflammatory and detumescent effects; frankincense has broad-spectrum antibacterial properties; frankincense resin has certain antioxidant activity; frankincense extracts can prevent gastric ulcers; vinegar-processed frankincense can reduce platelet adhesion; and frankincense has anti-tumor effects by inhibiting the spread and progression of tumor cells. (See "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, New Century Fifth Edition).

[0027] In this embodiment, the myrrh is the dried resin of the Oleaceae plant, the genus Myrrha. It is pungent, bitter, and neutral in nature and flavor; it enters the heart, liver, and spleen meridians. It has the effects of dispersing blood stasis, relieving pain, and reducing swelling and promoting tissue regeneration. Myrrh's main therapeutic effects are similar to those of frankincense, and it is often used in conjunction with frankincense to treat injuries from falls, pain caused by blood stasis, swelling and pain in carbuncles, persistent sores after ulceration, and various other pain syndromes caused by blood stasis. Modern pharmacology shows that it primarily contains volatile oils, resins, and furan sesquiterpenoids. The oily portion of myrrh has lipid-lowering effects and prevents the formation of atherosclerotic plaques in the arterial lining; myrrh extracts have significant analgesic effects; myrrh volatile oil and resins have anti-tumor properties; myrrh decoctions and volatile oils have antibacterial and anti-inflammatory effects; myrrh volatile oil can inhibit uterine smooth muscle contractions; and myrrh extracts have hepatoprotective effects. (See "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, 2007, 5th edition).

[0028] In this embodiment, the gardenia is the dried mature fruit of the Rubiaceae plant Gardenia jasminoides. It is bitter and cold in nature and enters the heart, lung, and triple burner meridians. It has the effects of purging heat and relieving restlessness, clearing heat and dampness, cooling blood and detoxifying. It can be used externally to reduce swelling and relieve pain, and can treat fever, damp-heat jaundice, painful stranguria, vomiting and bleeding due to blood heat, red and swollen eyes, ulcers caused by heat, and sprains and contusions. Modern pharmacology shows that it mainly contains gardenoside, hydroxyisogardenoside, gardeniain, crocin, crocetin, gardenia formic acid, gardenia acetic acid, and chlorogenic acid. It also contains volatile oils, polysaccharides, choline, and various trace elements. This product has hepatoprotective and choleretic effects, promoting bile secretion and bilirubin excretion, and lowering blood bilirubin. Its decoction can reduce pancreatic amylase, promote pancreatic secretion, enhance the disease resistance of pancreatic glandular cells in pancreatitis, and significantly increase normal hepatic blood flow. Gardenia jasminoides total glucosides can increase gastric mucosal blood flow, boost NO levels and NOS activity, and reduce ICAM-1 expression in gastric tissue, demonstrating a significant protective effect against gastric mucosal damage. Furthermore, it has antipyretic, analgesic, antibacterial, anti-inflammatory, sedative, and hypotensive effects. (See "Chinese Materia Medica," edited by Zhong Gansheng, published by China Traditional Chinese Medicine Press, New Century Fifth Edition).

[0029] In the Miao medicine traumatology liquid provided in this embodiment, Callicarpa ulmoides dissipates blood stasis and stops bleeding, reduces swelling and relieves pain, Polygonum cuspidatum clears away heat and detoxifies, dissipates blood stasis and relieves pain, and Leonurus japonicus clears heat and detoxifies, promotes blood circulation and relieves swelling, and these three are collectively the main medicines; Sanguisorba officinalis and Herba Achyranthis Bidentatae promote blood circulation and stop bleeding, resolve blood stasis and relieve swelling, Honeysuckle, Phellodendron amurense, and Gardenia jasminoides clear heat and detoxifies, purges fire and relieves pain, and are collectively the ministerial medicines; Turmeric, frankincense, and myrrh dissipate blood stasis and promote qi circulation, reduce swelling and relieve pain, and are collectively the adjuvant medicines; the combination of these medicines, which promotes blood circulation and clears heat, has a significant synergistic effect of promoting blood circulation, removing blood stasis, and relieving swelling and relieving pain in patients with fractures.

[0030] The Miao medicine Shangke liquid provided in this embodiment can achieve the therapeutic effect of reducing swelling and relieving pain in patients with fractures through a synergistic mechanism of multiple targets and multiple pathways. The following analyzes the synergistic effects of each component from the perspective of modern pharmacology:

[0031] In the monarch drug group, Callicarpa serrata: Its flavonoids and phenylethanoid glycosides activate the endogenous and exogenous coagulation systems, shortening clotting time and reducing local bleeding. They also inhibit plasma thromboxane levels, regulate microcirculation, and alleviate swelling associated with stasis. Their analgesic and anti-inflammatory effects can alleviate pain associated with acute injuries. Polygonum cuspidatum: Anthraquinones (such as emodin) and polydatin inhibit the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, reducing the release of inflammatory mediators such as prostaglandins (PGE2) and leukotrienes (LTB4), lowering capillary permeability and alleviating inflammatory exudative swelling. Their antibacterial effects can prevent secondary infections. Leonurus herb: Leonurine reduces inflammatory responses by inhibiting neutrophil infiltration and the expression of inflammatory factors (TNF-α, IL-6). It also dilates blood vessels, improves local microcirculation, accelerates the clearance of metabolic waste, and promotes tissue repair. The combination of the three forms a triple mechanism of "hemostasis-anti-inflammation-promoting circulation", which can quickly control acute bleeding and inflammatory swelling and create conditions for subsequent repair.

[0032] In the adjuvant group, Sargentodoxae: The anthraquinone component (emodin) inhibits platelet aggregation and prevents thrombosis; it also inhibits pathogenic bacteria such as Staphylococcus aureus, reducing the risk of infection. Rubia cordifolia: The naphthoquinone component (rubia cordifolia) promotes the conversion of fibrinogen to fibrin, accelerating blood clot formation; its anti-inflammatory effect is achieved by inhibiting the NF-κB pathway, reducing the release of inflammatory factors. Honeysuckle and Phellodendron chinense: Chlorogenic acid and berberine synergistically inhibit Gram-positive bacteria (such as Staphylococcus aureus) and Gram-negative bacteria (such as Escherichia coli), blocking the inflammatory cascade caused by bacterial endotoxins. Gardenia jasminoides: Gardenia jasminoides exerts anti-inflammatory and analgesic effects by inhibiting the expression of COX-2 and iNOS, reducing the production of nitric oxide (NO) and prostaglandins; its choleretic components promote the excretion of metabolic waste and reduce local tissue pressure. This group of drugs balances the coagulation and anticoagulation mechanisms (the anticoagulant effect of Sargentophyllum serrata and the procoagulant effect of Rubia cordifolia complement each other), while preventing infection and alleviating secondary inflammation through broad-spectrum antibacterial and anti-endotoxin effects.

[0033] In the adjuvant group, turmeric: Curcumin reduces the release of inflammatory mediators by inhibiting the NF-κB and MAPK signaling pathways; it also upregulates β-endorphin levels, directly acting on opioid receptors in the central nervous system to relieve pain. Frankincense and myrrh: Volatile oils (such as α-pinene) and resin components block peripheral pain transmission by inhibiting TRPV1 channels and bradykinin release; their antioxidant activity (such as scavenging ROS) protects damaged tissues from oxidative stress, promotes fibroblast proliferation, and accelerates callus formation. The three form a "peripheral-central" dual analgesic network, and simultaneously shorten the fracture healing period through antioxidant and pro-repair effects.

[0034] This embodiment optimizes the drug ratio and forms an integrated "hemostasis-anti-inflammatory-analgesia-promoting repair" action network through the coordinated regulation of multiple components and multiple links, ultimately achieving rapid swelling and pain relief for fracture patients, while providing a good microenvironment for bone healing; through clinical verification, the swelling reduction time is shortened to ≤3 days, and the total effective rate is 96.67%, confirming its significant therapeutic effect on injuries such as distal radius fractures, filling the gap in the modern research of Miao medicine compounds.

[0035] In some embodiments, a method for preparing the Miao medicine injury solution for reducing swelling and relieving pain at fractures according to the present invention is also provided, such as Figure 1 As shown, it includes the steps of:

[0036] S10. Weigh the following medicinal materials by weight: Callicarpa grandiflora, Sargentodoxae truncatula, Honeysuckle, Polygonum cuspidatum, Phellodendron amurense, Rubia cordifolia, Curcuma longa, Motherwort, Frankincense, Myrrh, and Gardenia jasminoides;

[0037] S20. Add the medicinal materials into a high-pressure decoction machine, then add common drinking water until it covers the surface of the medicinal materials by 3-5 cm, soak for 20-30 minutes, first heat with high heat until the medicinal liquid boils, then simmer with low heat for 30-50 minutes, and the filtered medicinal liquid is the Miao medicine trauma liquid for reducing swelling and relieving pain in fractures.

[0038] The method for preparing the Miao medicine injury liquid provided in the present embodiment has relatively simple operation steps. It is only necessary to put the weighed medicinal materials into a high-pressure decoction machine, add an appropriate amount of water, decoct them according to a certain degree of heat and time, and finally filter out the medicinal liquid. It does not require complicated equipment and technology and is convenient for actual production or family application. Before decocting the medicine, the medicinal materials are added to drinking water and soaked for 20-30 minutes, which allows the medicinal materials to fully absorb water and expand the cells, which is beneficial for the dissolution of the effective ingredients in the subsequent decoction process; first, heating the medicinal liquid with high heat until it boils can quickly heat the medicinal materials, accelerate cell rupture, promote the rapid dissolution of the effective ingredients into the medicinal liquid, shorten the decoction time, and improve efficiency; after the medicinal liquid boils, it is decocted with a slow fire for 30-50 minutes, which can allow the medicinal ingredients to be continuously and fully dissolved at a relatively mild temperature, while avoiding the problems of the medicinal liquid overflowing and the effective ingredients being destroyed due to continuous decoction with high heat, which is beneficial for protecting the effective ingredients in the medicinal materials and better exerting the drug effect.

[0039] In this embodiment, "high heat" and "low heat" are mainly distinguished based on the size of the firepower and the state of the medicinal liquid, rather than strictly corresponding to specific temperature values. High heat: that is, high heat or fierce fire, which usually makes the medicinal liquid boil quickly. At this time, the firepower is fully turned on and it is used to heat it to boiling quickly. Low heat: that is, low heat or slow fire, which maintains the medicinal liquid in a slightly boiling state to avoid violent boiling that causes the active ingredients to volatilize or the medicinal liquid to be over-concentrated. In this embodiment, the medicinal materials are added to a high-pressure decoction machine and the temperature is set to 110°C. At this time, high heat is used to quickly heat it to a boiling state to ensure the efficient dissolution of active ingredients such as flavonoids and anthraquinones and enhance the stability of the medicinal effect; after reaching the target temperature, the heating power is reduced and the constant temperature is maintained by low heat for a long time to ensure the stable dissolution of the active ingredients.

[0040] The present invention will be further explained below by means of specific embodiments:

[0041] 1. Specific cured cases

[0042] Case 1: Li XX, male, 33 years old, currently living in Taijiang County, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province. His main symptoms were swelling and pain in the right ankle joint, limited mobility, swelling of the right ankle, and acute tenderness in the medial malleolus caused by falling from a height. DR diagnosis showed: right medial malleolus fracture. After external application of 50ml / time of Miao medicine trauma solution of the present invention and external fixation with a fir bark splint, which was changed every 2-3 days for a course of 7 days, the patient completed 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line was basically gone, the ankle joint function gradually recovered, and he was completely cured.

[0043] Case 2: Tai XX, male, 63 years old, currently living in Fangzhao Township, Taijiang County, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province. The main symptoms are swelling and pain in the left calf, limited activity, swelling and tenderness in the left calf and left calf, and limited activity in the left ankle due to falling from a height. DR diagnosis showed: 1. Fracture of the distal end of the left tibia. 2. Comminuted fracture of the distal end of the left fibula. After external application of 50ml / time of Miao medicine trauma liquid of the present invention and external fixation with fir bark splint, which was changed every 2-3 days, and a course of 7 days, the patient underwent 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line basically disappeared, and the functional activity of the ankle joint gradually recovered, and the patient was completely cured.

[0044] Case 3: Yang XX, female, 55 years old, currently living in Nangong Township, Taijiang County, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province. The main symptoms are swelling and pain in the right shoulder with limited activity caused by falling, swelling and tenderness in the right shoulder, and limited activity of the right shoulder joint. DR diagnosis showed: right proximal humeral fracture. After external application of 50ml / time of Miao medicine trauma solution of the present invention and external fixation with fir bark splint, which was changed every 2-3 days and a course of 7 days, the patient went through 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line basically disappeared, the ankle joint function gradually recovered, and the patient was completely cured.

[0045] Case 4: Pan XX, female, 72 years old, currently living in Taigong Street, Taigong Town, Taijiang County, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province, the main symptoms are swelling and pain in the right wrist joint and limited movement caused by a fall. DR diagnosis shows: right proximal humeral fracture. After external application of 50ml / time of Miao medicine trauma solution of the present invention and external fixation with fir bark splint, which was changed every 2-3 days, and a course of 7 days, the patient completed 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line basically disappeared, the functional activity of the wrist joint gradually recovered, and the patient was completely cured.

[0046] Case 5: Zhou XX, female, 56 years old, currently resides in Group 3, Baocun, Nangong Township, Taijiang County, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province. The main symptoms are swelling and pain in the right wrist joint and limited activity caused by falling. The right wrist is swollen, with a stab-like deformity, sharp local tenderness, palpable bone friction, positive axial percussion pain, and limited right wrist joint activity. Diagnosis by DR shows: fracture of the right distal radius and right ulnar styloid process. 50ml / sub-application of the Miao medicine trauma liquid of the present invention, external fixation of fir bark splint, changing once every 2-3 days, 7 days as a course of treatment, the patient is through 6 courses of treatment, the fracture segment alignment is good, obvious callus can be seen in the fracture end, the fracture line basically disappears, and the functional activity of the wrist joint gradually recovers, and is completely cured.

[0047] Case 6: Zhang XX, male, 16 years old, currently lives in Zhangjia Village, Xiumei Street, Taigong Town, Taijiang County, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province. The main symptoms are swelling and pain in the left elbow with limited activity caused by falling. The left elbow is swollen, the medial tenderness of the left elbow joint is sharp, axial percussion pain (+), and the left elbow joint is limited in activity. DR diagnosis showed: supracondylar fracture of the left humerus. After external application of 50ml / time of Miao medicine traumatology liquid of the present invention and external fixation with fir bark splint, which was replaced every 2-3 days and 7 days as a course of treatment, the patient was treated with 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line basically disappeared, the functional activity of the wrist joint gradually recovered, and the patient was completely cured.

[0048] Case 7: Liu XX, male, 16 years old, currently lives in Xiumei Avenue, Taijiang County, Qiandongnan Prefecture, Guizhou Province. His main symptoms are pain and swelling in the right forearm caused by a fall. The right wrist joint is "fork-like" deformity, the right wrist joint is obviously swollen, the right wrist joint is acutely tender, bone friction can be palpated, axial percussion pain is positive, and the right wrist joint movement is limited. DR diagnosis shows: right distal ulna and radius fracture. After external application of 50ml / time of Miao medicine trauma liquid of the present invention and external fixation with fir bark splint, which is replaced every 2-3 days and a course of 7 days, the patient has undergone 6 courses of treatment. The fracture segment is well aligned, obvious callus can be seen at the fracture end, the fracture line has basically disappeared, the functional activity of the wrist joint has gradually recovered, and the patient has completely recovered.

[0049] Case 8: Ou XX, male, 21 years old, currently living in Taigong Town, Taijiang County, Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou Province. The main symptoms are swelling and pain in the left forearm and limited activity due to a fall. The left forearm is swollen and the wrist joint is pronated. No subcutaneous bruises or ecchymosis are seen. The lower 1 / 3 of the left forearm is tender, and bone friction and abnormal activity can be palpated. The left wrist joint is limited in activity. The left elbow joint is slightly swollen and tender. The left elbow joint activity is not limited. DR diagnosis shows: 1. Left radial shaft fracture, 2. Dislocation of the left inferior radioulnar joint, 3. Left elbow contusion. After 50ml / time external application of the present invention and external fixation with a fir bark splint, which is replaced every 2-3 days, and 7 days as a course of treatment, the patient has undergone 6 courses of treatment. The fracture segment is well aligned, obvious callus can be seen at the fracture end, the fracture line has basically disappeared, and the functional activity of the wrist joint has gradually recovered, and the patient has completely recovered.

[0050] Case 9: Pan XX, male, 66 years old, currently living in Miaojiang West Avenue, Taijiang County, Qiandongnan Prefecture, Guizhou Province. The main symptoms are left heel pain caused by falling from a height, swelling of the left heel, subcutaneous ecchymosis, widening of the transverse diameter of the calcaneus, flattening of the arch of the foot, acute tenderness of the calcaneus, palpable bone friction and abnormal activity, and limited left ankle movement. DR diagnosis showed: left calcaneal comminuted fracture. After external application of 50ml / time of Miao medicine trauma liquid of the present invention and external fixation of fir bark splint, which was changed every 2-3 days and 7 days as a course of treatment, the patient was treated with 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, and the fracture line was blurred. The functional activity of the ankle joint gradually recovered and was completely cured.

[0051] Case 10: Yang XX, male, 51 years old, currently living in Litang Lane, Taijiang County, Qiandongnan Prefecture, Guizhou Province. His main symptoms were swelling and pain in his left upper arm with limited mobility due to an accidental fall, mild swelling of the left upper arm, mild adduction deformity, mild tenderness in the middle section of the left humerus, and limited mobility of the left upper arm. DR diagnosis showed: left humeral middle section fracture. After 6 courses of treatment with 50ml / time external application of the present invention and external fixation with a fir bark splint, which was replaced every 2-3 days, with a course of 7 days, the patient showed good alignment of the fracture segments, obvious callus at the fracture ends, blurred fracture lines, and gradual recovery of shoulder and elbow joint functional activities, with complete recovery.

[0052] Case 11: Wan XX, male, 16 years old, currently living in Taoyuan Community, Taigong Town, Taijiang County, Qiandongnan Prefecture, Guizhou Province. The main symptoms are swelling and pain in the right wrist, limited mobility, swelling of the right wrist due to a fall, no obvious deformity, no skin lesions, no subcutaneous bruising, slightly high skin temperature, acute tenderness around the right wrist joint, positive axial percussion pain, and limited mobility of the right wrist joint. DR diagnosis showed: right distal radius greenstick fracture. After external application of 50ml / time of the Miao medicine trauma solution of the present invention and external fixation with a fir bark splint, which was changed every 2-3 days, with a course of 7 days, the patient underwent 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line was blurred, and the functional activity of the wrist joint gradually recovered, and the patient was completely cured.

[0053] Case 12: Wu XX, male, 14 years old, currently lives in Group 4, Fangzhao Village, Fangzhao Township, Taijiang County, Qiandongnan Prefecture, Guizhou Province. His main symptoms are swelling and pain in the left wrist and limited movement due to a fall. The left wrist is swollen, and the side view shows a "fork-like" deformity. There is acute tenderness around the left wrist joint, positive axial percussion pain, and limited movement of the left wrist joint. DR diagnosis showed: greenstick fracture of the distal left radius. After external application of 50ml / time of the Miao medicine trauma liquid of the present invention and external fixation with a fir bark splint, which was replaced every 2-3 days, and a course of treatment of 7 days, the patient went through 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line was blurred, the functional activity of the wrist joint gradually recovered, and the patient was completely cured.

[0054] Case 13: Zhang XX, female, 56 years old, currently lives in Gaoyang Village, Laotun Township, Taijiang County, Qiandongnan Prefecture, Guizhou Province. The main symptoms are swelling and pain in the left wrist and limited movement due to a fall. The left wrist is swollen, with a bayonet-like deformity and a fork-like deformity. The skin temperature is slightly higher, the tenderness around the left wrist joint is acute, the axial percussion pain is positive, and the left wrist joint movement is limited. DR diagnosis showed: left distal radius fracture. After external application of 50ml / time of the Miao medicine trauma liquid of the present invention and external fixation with a fir bark splint, which was changed every 2-3 days and a course of 7 days, the patient went through 6 courses of treatment. The fracture segment was well aligned, obvious callus was visible at the fracture end, the fracture line was blurred, the functional activity of the wrist joint gradually recovered, and the patient was completely cured.

[0055] 2. Clinical Trials

[0056] 1. Case sources and group treatment

[0057] Patients with fresh distal radius fractures undergoing conservative treatment were recruited from the orthopedics clinic of Taijiang County National Traditional Chinese Medicine Hospital and divided into an observation group and a control group, with 30 cases in each group. The observation group received manual reduction and splint fixation, external application of the Chinese medicine in the example, and oral administration of celecoxib capsules, while the control group received manual reduction and splint fixation, and oral administration of celecoxib capsules, as follows:

[0058] 1.1. Restoration method

[0059] Extension fracture: Under anesthesia, the patient lies on his back with his elbow flexed 90°. Two assistants pull and tug to correct overlapping displacement. The surgeon uses expansion, folding, reverse pulling, lifting, pressing, and internal and external pushing techniques to correct dorsal and radial displacement, while also flexing and ulnar deviation of the wrist joint.

[0060] Flexion fracture: If necessary, under anesthesia, the patient lies on his back with his elbow flexed 90°. Two assistants perform traction and the surgeon uses lifting, pressing, lowering, and internal and external pushing techniques to correct palmar and radial displacement. The assistant slowly extends the wrist joint dorsiflexion and ulnar deviation.

[0061] 1.2 Small splint fixation method

[0062] Non-displaced fractures are fixed with four small splints.

[0063] Extension fracture: After reduction, apply local medication, place a flat pad on the dorsal and proximal palm sides of the distal end of the fracture, and then place a small splint. The upper end of the splint should reach the upper and middle 1 / 3 of the forearm, and the lower end of the radial dorsal splint should exceed the wrist joint. Bandage it and fix it, and suspend the forearm on the chest.

[0064] Flexion fracture: After reduction, apply local medication, place a flat pad on the distal palm side and proximal dorsal side of the fracture, and place the lower end of the radial palm splint beyond the wrist joint. After the splint is fixed, a "mushroom head" splint can be placed on the palm side to fix the wrist joint in the dorsiflexion position.

[0065] 1.3 External application of the Miao medicine trauma liquid of the present invention: external application to the fracture site, the dosage of the liquid is 20 ml, the dressing is changed for the first time after 3 days, and then once every 5 days. During the dressing change period, the liquid is poured into the gap between the splints, once a day, 10 ml each time.

[0066] 1.4 Celecoxib capsules (0.2g / capsule, 20 capsules / box, Guowei Pharmaceutical, approval number: National Medicine Standard H20203357, orally taken after meals, 1 capsule at a time, twice a day).

[0067] 2. Diagnosis, classification, inclusion and exclusion criteria

[0068] 2.1 Diagnostic criteria

[0069] Refer to the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes" (ZY / T001.9-94) "Distal Radius Fracture" of the Traditional Chinese Medicine Industry Standard of the People's Republic of China issued by the State Administration of Traditional Chinese Medicine in 1994.

[0070] (1) There is a history of trauma, mostly caused by indirect violence.

[0071] (2) After the injury, there is swelling and pain around the wrist joint, deformity of the lower forearm, obvious tenderness, and dysfunction of wrist and arm movement.

[0072] (3) X-ray examination can confirm the diagnosis.

[0073] 2.2 Classification criteria

[0074] Refer to the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes" (ZY / T001.9-94) "Distal Radius Fracture" of the Traditional Chinese Medicine Industry Standard of the People's Republic of China issued by the State Administration of Traditional Chinese Medicine in 1994.

[0075] (1) Non-displaced type: The fracture is not displaced, or may be a mild embedded fracture, with mild swelling of the wrist joint, no obvious deformity, annular tenderness at the fracture end, longitudinal impact pain, and forearm rotation dysfunction.

[0076] (2) Extension type: The distal end is displaced dorsally, the lower end of the forearm presents a "fork-like" deformity, and a distal bone protrusion of the fracture can be palpated on the dorsal side of the wrist.

[0077] (3) Flexion type: The distal fracture end is displaced toward the palmar side, and the distal radioulnar joint may be dislocated. The distal bone protrusion of the fracture can be palpated on the palmar side of the wrist joint. The deformity is opposite to the extension type.

[0078] (4) Subluxation type: fracture of the dorsal margin of the distal radius, combined with subluxation of the wrist joint, swelling of the wrist joint, deformity in the shape of subluxation, and widening of the transverse diameter of the wrist.

[0079] 2.3 Inclusion criteria

[0080] (1) Aged 16-80 years. (2) Meet the above diagnostic criteria. (3) AO fracture type A or B. (4) Agree to randomization and treatment.

[0081] 2.4 Exclusion criteria

[0082] (1) Unable to cooperate with treatment. (2) Suffering from severe systemic diseases and unable to receive treatment. (3) Open injury at the fracture site. (4) Old fracture.

[0083] 2.5 Rejection and shedding standards

[0084] During the trial, subjects may not respond to treatment, or even have their condition aggravated or experience serious complications and serious adverse events; subjects may withdraw from the trial midway; subjects may not be followed up because they no longer receive medication or testing although they have not explicitly requested to withdraw from the trial; subjects may be found not to meet the inclusion criteria after enrollment; subjects may use banned drugs specified in the protocol; subjects may have their clinical research terminated or suspended early due to safety reasons determined by the researchers.

[0085] 3. Observation indicators

[0086] The degree of wrist swelling and the effect of swelling reduction were evaluated before treatment and on the third, sixth, and ninth days after treatment (with the degree of swelling reduction and the number of days as indicators, according to the "Guiding Principles for Clinical Research of Traditional Chinese Medicine"). The results were divided into markedly effective (anterior-posterior difference in the circumference of the swollen limb ≥ 0.9 cm, and swelling reduction time ≤ 3 days; effective (anterior-posterior difference in the circumference of the swollen limb 0.4-0.8 cm, and swelling reduction time 3-6 days; ineffective (anterior-posterior difference in the circumference of the swollen limb ≤ 0.2 cm, and swelling reduction time ≥ 6 days) and VAS scores. Adverse reactions observed included tension blisters, rash, and skin lesions.

[0087] 4. Test results

[0088] 4.1 Analysis of general information of the two groups of patients

[0089] The observation group included 12 males and 18 females, with a mean age of (54.38 ± 15.55) years. Among them, there were 2 cases of nondisplaced fractures, 21 cases of extension fractures, 7 cases of flexion fractures, and 0 cases of subluxation. The control group included 14 males and 16 females, aged 14 to 72 years (mean, (52.71 ± 17.93) years). Among them, there were 2 cases of nondisplaced fractures, 23 cases of extension fractures, 5 cases of flexion fractures, and 0 cases of subluxation. There were no statistically significant differences in age, gender, fracture type, and other general data among the three groups (P > 0.05), indicating comparability, as shown in Table 1.

[0090] Table 1 Data comparison

[0091]

[0092] 4.2 Comparison of swelling reduction effects between the two groups

[0093] The degree of swelling in the observation group was lower than that in the control group on days 3, 6, and 9 after treatment (P<0.05), as shown in Table 2. The swelling reduction effect in the observation group was better than that in the control group (P<0.05), as shown in Table 3.

[0094] Table 2 Comparison of swelling degree between the two groups on the 3rd, 6th and 9th day after treatment

[0095]

[0096] Table 3 Comparison of swelling reduction effect between the two groups

[0097]

[0098] 4.3 Comparison of pain and complications between the two groups

[0099] The pain levels of the observation group were lower than those of the control group on the 3rd, 6th, and 9th days after treatment, and the difference was statistically significant (P<0.05). There was no statistical difference in the incidence of complications between the two groups (P>0.05), as shown in Table 4.

[0100] Table 4 Comparison of pain severity and complication rates between the two groups

[0101]

[0102] In summary, in the Miao medicine traumatology liquid provided by the present invention, Callicarpa macrophylla has the functions of dispersing blood stasis and stopping bleeding, reducing swelling and relieving pain, Polygonum cuspidatum clears away heat and detoxifies, dispersing blood stasis and relieving pain, and Leonurus japonicus clears away heat and detoxifies, and promotes blood circulation and reduces swelling, and the three are collectively the main medicines; Sanguisorba officinalis and Herba Achyranthis Bidentatae promote blood circulation and stop bleeding, resolve blood stasis and reduce swelling, while Honeysuckle, Phellodendron amurense and Gardenia jasminoides clear away heat and detoxifies, and clears fire and relieves pain, and are collectively the ministerial medicines; Curcuma longa, frankincense and myrrh remove blood stasis, promote qi circulation, reduce swelling and relieve pain, and are collectively the adjuvant medicines; all the medicines are used together to promote blood circulation and clear away heat, and have significant effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain in patients with fractures.

[0103] It should be understood that the application of the present invention is not limited to the above examples. For those skilled in the art, improvements or changes can be made based on the above description. All these improvements and changes should fall within the scope of protection of the claims attached to the present invention.

Claims

1. A Miao medicine traumatology liquid for reducing swelling and relieving pain at fractures, characterized in that: The Miao medicine injury liquid comprises, by weight, 10-20 parts of Callicarpa macrophylla, 10-20 parts of Sargentodoxae cyrtonema, 15-20 parts of honeysuckle, 10-15 parts of Polygonum cuspidatum, 10-15 parts of Phellodendron amurense, 15-20 parts of Rubia cordifolia, 10-15 parts of Curcuma longa, 10-20 parts of Leonurus japonicus, 6-8 parts of frankincense, 6-8 parts of myrrh, and 10-15 parts of Gardenia jasminoides.

2. The Miao medicine traumatology liquid for reducing swelling and relieving pain in fractures according to claim 1, characterized in that: The Miao medicine injury liquid comprises, by weight, 15 parts of Callicarpa macrophylla, 15 parts of Sargentodoxae cuneata, 18 parts of honeysuckle, 12 parts of Polygonum cuspidatum, 12 parts of Phellodendron chinense, 18 parts of Rubia cordifolia, 12 parts of Curcuma longa, 15 parts of Leonurus japonicus, 7 parts of frankincense, 7 parts of myrrh, and 12 parts of Gardenia jasminoides.

3. The Miao medicine traumatology liquid for reducing swelling and relieving pain in fractures according to claim 1, characterized in that: The Miao medicine injury liquid comprises, by weight: 10 parts of Callicarpa macrophylla, 10 parts of Sargentodoxae cuneata, 15 parts of honeysuckle, 10 parts of Polygonum cuspidatum, 10 parts of Phellodendron chinense, 15 parts of Rubia cordifolia, 10 parts of Curcuma longa, 10 parts of Leonurus japonicus, 6 parts of frankincense, 6 parts of myrrh, and 10 parts of Gardenia jasminoides.

4. The Miao medicine traumatology liquid for reducing swelling and relieving pain in fractures according to claim 1, characterized in that: The Miao medicine injury liquid comprises, by weight: 20 parts of Callicarpa macrophylla, 20 parts of Sargentodoxae cuneata, 20 parts of honeysuckle, 15 parts of Polygonum cuspidatum, 15 parts of Phellodendron chinense, 20 parts of Rubia cordifolia, 15 parts of Curcuma longa, 20 parts of Leonurus japonicus, 8 parts of frankincense, 8 parts of myrrh, and 15 parts of Gardenia jasminoides.

5. A method for preparing a Miao medicine traumatic solution for reducing swelling and relieving pain in fractures as claimed in any one of claims 1 to 4, characterized in that: Including steps: Weigh the following medicinal materials by weight: Callicarpa grandiflora, Sargentodoxae spatholobi, honeysuckle, Polygonum cuspidatum, Phellodendron amurense, Rubia cordifolia, turmeric, motherwort, frankincense, myrrh, and gardenia; The medicinal materials are added into a high-pressure decoction machine, and then common drinking water is added until it covers the surface of the medicinal materials by 3-5 cm. After soaking for 20-30 minutes, the medicinal liquid is first heated with high heat until it boils, and then simmered with low heat for 30-50 minutes. The filtered medicinal liquid is the Miao medicine trauma liquid used for reducing swelling and relieving pain in fractures.

6. The method for preparing the Miao medicine traumatic liquid for reducing swelling and relieving pain in fractures according to claim 5, characterized in that: The Miao medicine injury liquid is a liquid for external use.

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