Bacteriostatic wet tissue containing plant extract and preparation process thereof

Abstract

The invention provides a bacteriostatic wet tissue containing a plant extract and a preparation process of the bacteriostatic wet tissue, and belongs to the technical field of bacteriostatic wet tissue preparation. The preparation process comprises the following steps: preparing a dialdehyde starch-catechin grafted copolymer; preparing the composite nano particles; preparing the antibacterial viscose fibers; pretreating the non-woven fabric; and preparing the antibacterial wet tissue. Through the synergistic effect of a plurality of antibacterial components, common pathogenic bacteria can be rapidly inhibited, and the hand sanitizer does not contain irritant components such as alcohol and formaldehyde, is mild and non-irritant, and is suitable for children and people with sensitive skin to use.

Description

Technical Field

[0001] The present invention relates to the technical field of antibacterial wet wipe preparation, and in particular to an antibacterial wet wipe containing a plant extract and a preparation process thereof. Background Art

[0002] With the rapid development of the global economy and the significant improvement in people's living standards, the use of cleaning and hygiene products in daily life has become increasingly widespread. Wet wipes, as convenient and efficient cleaning products, have become essential in various fields, including household, medical, and travel. At the same time, consumers' growing awareness of health and environmental protection has led to more stringent requirements for the safety, functionality, and environmental friendliness of wet wipes. Traditional wet wipes are no longer able to meet current market demand, and the development of new wet wipes with multiple advantages has become an inevitable trend in the industry.

[0003] Among existing wet wipes, some products, in pursuit of highly effective antibacterial effects, contain large amounts of chemical fungicides, such as benzalkonium chloride and triclosan. While these chemical fungicides effectively inhibit bacterial growth, they also pose potential safety risks. Long-term contact with or use of wet wipes containing these ingredients can cause skin irritation, disrupting the skin's natural barrier function and leading to adverse reactions such as allergies, redness, and swelling. Furthermore, chemical fungicides are difficult to degrade in the natural environment, causing ecological pollution and incompatible with current green and environmentally friendly development concepts.

[0004] Another group of wet wipes, marketed as mild, reduce the use of chemical additives, but their antibacterial properties are weak, failing to effectively kill common pathogens like E. coli and Staphylococcus aureus. This makes them unable to meet the high standards of cleanliness and hygiene required in specialized settings, such as healthcare and food processing. Furthermore, these wipes typically lack skin care functions, providing only basic cleansing and failing to meet consumers' growing demand for skin health.

[0005] Therefore, we proposed an antibacterial wet wipe containing plant extracts and its preparation process, which is not only environmentally friendly but also has efficient antibacterial function, is gentle and does not irritate the skin, and can also achieve skin care. Summary of the Invention

[0006] In view of the shortcomings of the prior art, the object of the present invention is to provide an antibacterial wet wipe containing plant extracts and a preparation process thereof.

[0007] A process for preparing antibacterial wet wipes containing plant extracts comprises the following steps: S1: Preparation of dialdehyde starch-catechin graft copolymer S2: Preparation of composite nanoparticles Microcrystalline cellulose is reacted with 6-bromohexanoyl chloride to prepare an intermediate product, which is added to N,N-dimethylacetamide and then reacted with N,N-dimethyltetradecylamine to prepare quaternized cellulose, which is then compounded with citric acid to prepare composite nanoparticles; S3: Preparation of antibacterial viscose fiber Antibacterial viscose fibers were prepared by adding collagen peptide, PVA and dialdehyde starch-catechin graft copolymer into viscose spinning solution for spinning. S4: Pretreatment of nonwoven fabrics An antibacterial finishing agent is prepared by mixing composite nanoparticles, sodium dodecyl sulfate, deionized water and aqueous polyurethane emulsion, an antibacterial viscose fiber is mixed with lyocell fiber to prepare a non-woven fabric, and the non-woven fabric is impregnated in the antibacterial finishing agent to obtain a pretreated non-woven fabric; S5: Preparation of antibacterial wipes Honeysuckle extract, Centella asiatica extract, calcium pyrrolidonecarboxylate, trehalose, citric acid, double-chain quaternary ammonium salt, alkyl glucoside and deionized water are mixed to prepare a wet wipe liquid, and the pretreated non-woven fabric is lubricated with the wet wipe liquid to obtain an antibacterial wet wipe.

[0008] Furthermore, step S1 of preparing the dialdehyde starch-catechin graft copolymer specifically comprises the following steps: S1.1: Add 1.25-1.42 parts by weight of dialdehyde starch to 3.3-3.5 parts by weight of a 1 mol / L hydrochloric acid aqueous solution, and stir to obtain a dialdehyde starch solution; S1.2: Add 0.62-1.32 parts by weight of catechin to 6.7-8.2 parts by weight of dimethyl sulfoxide, and stir for 30-40 minutes to obtain a catechin solution; S1.3: After mixing the dialdehyde starch solution and the catechin solution, react at 40-45° C. in the dark for 48-50 hours to obtain a reaction solution. The reaction solution is dialyzed against deionized water for 72-74 hours and then freeze-dried to obtain a dialdehyde starch-catechin graft copolymer.

[0009] Furthermore, step S2 of preparing the composite nanoparticles specifically includes the following steps: S2.1: Add 0.5-0.8 parts by weight of microcrystalline cellulose to 25-30 parts by weight of N,N-dimethylacetamide, stir and mix at 80-90°C for 20-30 minutes, then add 0.3-0.5 parts by weight of 6-bromohexanoyl chloride, react for 2-3 hours, then add 150-200 parts by weight of ethanol, stir for 1-2 hours, and then centrifuge to obtain an intermediate product; S2.2: 2-3 parts by weight of the intermediate product are added to N,N-dimethylacetamide to prepare a 25 mg / mL N,N-dimethylacetamide solution, which is then heated to 90-100°C. 5-8 parts by weight of N,N-dimethyltetradecylamine are then added. The reaction is carried out for 4-5 hours, followed by ethanol dialysis in a dialysis bag with a molecular weight cut-off of 3500. After dialysis, the solution is rotary evaporated to obtain the quaternized cellulose. S2.3: Add quaternized cellulose to ethanol to prepare a 20-25 mg / mL ethanol solution, then add citric acid and stir to obtain a mixed solution, wherein the citric acid accounts for 35-50 wt% of the mixed solution. Transfer the mixed solution to a dialysis bag with a molecular cutoff of 3500 for dialysis. After the dialysis is completed, filter to obtain composite nanoparticles.

[0010] Furthermore, step S3 of preparing the antibacterial viscose fiber specifically includes the following steps: S3.1: Add 0.56-1.23 parts by weight of a 20 wt% collagen peptide solution, 0.92-1.39 parts by weight of a 10 wt% PVA solution, and 3-5 parts by weight of a dialdehyde starch-catechin graft copolymer to 50-60 parts by weight of a viscose spinning solution, stir and mix for 20-30 minutes, and filter and degas the mixed solution to obtain a blended spinning solution; S3.2: The blended spinning solution is spun at a spinning speed of 15-16 m / min, a first roller speed of 14.825 m / min, a second roller speed of 22.196 m / min, a drafting multiple of 1.4-1.6 times, a coagulation bath length of 1.8-2.0 m, and 60-65°C, and then post-processed to prepare antibacterial viscose fiber.

[0011] Furthermore, step S4 of pre-treating the non-woven fabric specifically includes the following steps: S4.1: Add 13-15 parts by weight of composite nanoparticles and 5-8 parts by weight of sodium lauryl sulfate to 100-120 parts by weight of deionized water, then add 23-25 ​​parts by weight of an aqueous polyurethane emulsion, and stir at 300-500 rpm for 20-30 minutes to obtain an antibacterial finishing agent; S4.2: Antibacterial viscose fiber and lyocell fiber are mixed in a ratio of 3-5:1 to prepare a non-woven fabric, the non-woven fabric is immersed in an antibacterial finishing agent, and then ultrasonically treated at 30-50°C for 20-30 minutes, and then dried at 70-75°C for 3-5 minutes, and then dried at 35-40°C for 30-35 hours to obtain a pretreated non-woven fabric.

[0012] Furthermore, step S5 of preparing the antibacterial wet wipes specifically includes the following steps: S5.1: Mix 2-3 parts by weight of honeysuckle extract, 2-3 parts by weight of Centella asiatica extract, 1-2 parts by weight of calcium pyrrolidonecarboxylate, 0.21-0.42 parts by weight of trehalose, 0.3-0.5 parts by weight of citric acid, 0.13-0.15 parts by weight of a double-chain quaternary ammonium salt, 1-2 parts by weight of an alkyl glucoside, and 100-120 parts by weight of deionized water to obtain a wet wipes solution; S5.2: The pretreated non-woven fabric is wetted with a wet wipe liquid, sterilized after the wet treatment, and packaged to obtain antibacterial wet wipes.

[0013] Furthermore, in step S5.2, the weight ratio of the pretreated non-woven fabric to the wet wipes liquid is 1:2-4.

[0014] Disclosed is an antibacterial wet wipe containing a plant extract, which is prepared by the preparation process of the antibacterial wet wipe containing a plant extract.

[0015] Compared with the prior art, the present invention has at least the following beneficial effects: 1. The present invention can quickly inhibit common pathogens through the synergistic effect of multiple antibacterial ingredients, honeysuckle extract and double-chain quaternary ammonium salt, and does not contain irritating ingredients such as alcohol and formaldehyde. It is mild and non-irritating, suitable for children and people with sensitive skin. In addition, the calcium pyrrolidone carboxylate in the antibacterial wipes can synergize with the collagen synthesis of Centella asiatica by moisturizing and supplementing natural moisturizing factors, accelerate the barrier repair of sensitive skin, achieve a synergistic soothing effect, and realize skin care. Calcium pyrrolidone carboxylate is an electrolyte that can change the permeability of bacterial cell membranes and enhance the penetration efficiency of the antibacterial ingredients in honeysuckle, thereby improving the antibacterial effect.

[0016] 2. The present invention forms a stable structure through the grafting reaction of dialdehyde starch and catechin, which combines the strong oxidizing property of aldehydes and the polyphenol antibacterial mechanism of catechin. Catechins can destroy microbial cell membranes, inhibit enzyme activity and chelate metal ions, and have a broad-spectrum inhibitory effect on common pathogens such as Escherichia coli, Staphylococcus aureus, and Candida albicans. After grafting, the antibacterial components are not easily lost due to friction, ensuring the long-term antibacterial effect of the wet wipes. At the same time, the stability of catechins and the biological activity of polysaccharides can be improved, thereby enhancing the antibacterial ability. The antibacterial viscose fiber prepared by blending with collagen peptides has excellent antibacterial properties, making the wet wipes mild and non-irritating, and having skin-friendly and moisturizing capabilities.

[0017] 3. The present invention prepares nanoparticles with antibacterial function by using quaternized cellulose with a long alkane chain structure as a cation and compounding it with citric acid with an anionic structure through electrostatic action. The quaternary ammonium salt compound can be adsorbed onto the surface of the bacterial cell membrane through electrostatic action. The long alkane chain in the quaternary ammonium salt structure can then pierce the bacterial cell membrane and disintegrate it, causing leakage of intracellular substances and ultimately leading to cell apoptosis. The citric acid can effectively ionize the bacterial cell membrane and destroy the bacterial protein and cell membrane synthesis system, thereby achieving the effect of inhibiting bacterial growth. The composite nanoparticles can achieve antibacterial effects from multiple angles, thereby enhancing the antibacterial ability of the antibacterial wipes. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable one skilled in the art to make and use the invention.

[0019] Figure 1 This is a flow chart of the preparation process of antibacterial wet wipes containing plant extracts used in an embodiment of the present invention. DETAILED DESCRIPTION

[0020] The following describes in detail, with reference to the accompanying drawings and specific examples, an antibacterial wet wipe containing a plant extract and its preparation process provided by the present invention. It is also noted that, to provide a more detailed description, the following examples are best and preferred embodiments, and those skilled in the art may employ alternative methods for implementing certain known techniques. Furthermore, the accompanying drawings are intended only to provide a more detailed description of the embodiments and are not intended to limit the present invention.

[0021] Intermediate product structure diagram:

[0022] Quaternized cellulose structure diagram:

[0023] Example 1 A preparation process of antibacterial wet wipes containing plant extracts, such as Figure 1 As shown, the following steps are included: S1: Preparation of dialdehyde starch-catechin graft copolymer S1.1: Add 1.25 parts by weight of dialdehyde starch to 3.3 parts by weight of a 1 mol / L hydrochloric acid aqueous solution, and stir to obtain a dialdehyde starch solution; S1.2: Add 0.62 parts by weight of catechin to 6.7 parts by weight of dimethyl sulfoxide, and stir for 30 minutes to obtain a catechin solution; S1.3: Mix the dialdehyde starch solution and the catechin solution and react them in the dark at 40°C for 48 hours to obtain a reaction solution. The reaction solution is dialyzed against deionized water for 72 hours and then freeze-dried to obtain a dialdehyde starch-catechin graft copolymer. S2: Preparation of composite nanoparticles S2.1: Add 0.5 parts by weight of microcrystalline cellulose to 25 parts by weight of N,N-dimethylacetamide, stir and mix at 80°C for 20 minutes, then add 0.3 parts by weight of 6-bromohexanoyl chloride, react for 2 hours, then add 150 parts by weight of ethanol, stir for 1 hour, and then centrifuge to obtain an intermediate product; S2.2: 2 parts by weight of the intermediate product was added to N,N-dimethylacetamide to prepare a 25 mg / mL N,N-dimethylacetamide solution. The solution was then heated to 90°C and 5 parts by weight of N,N-dimethyltetradecylamine was added. The reaction was allowed to proceed for 4 h. The solution was then dialyzed against ethanol in a dialysis bag with a molecular weight cut-off of 3500. After completion of the dialysis, the solution was rotary evaporated to obtain the quaternized cellulose. S2.3: Adding quaternized cellulose to ethanol to prepare a 20 mg / mL ethanol solution, then adding citric acid and stirring to obtain a mixed solution, wherein the citric acid accounts for 35 wt % of the mixed solution. Transferring the mixed solution to a dialysis bag with a molecular weight cut-off of 3500 for dialysis. After the dialysis is complete, filtering to obtain composite nanoparticles; S3: Preparation of antibacterial viscose fiber S3.1: To 50 parts by weight of viscose spinning solution, 0.56 parts by weight of a 20 wt% collagen peptide solution, 0.92 parts by weight of a 10 wt% PVA solution, and 3 parts by weight of a dialdehyde starch-catechin graft copolymer were added and stirred for 20 minutes. The mixed blend was filtered and degassed to obtain a blended spinning solution; S3.2: The blended spinning solution was spun at a spinning speed of 15 m / min, a first roller speed of 14.825 m / min, a second roller speed of 22.196 m / min, a draft ratio of 1.4, a coagulation bath length of 1.8 m, and 60°C, followed by post-processing to produce an antibacterial viscose fiber. S4: Pretreatment of nonwoven fabrics S4.1: Add 13 parts by weight of composite nanoparticles and 5 parts by weight of sodium lauryl sulfate to 100 parts by weight of deionized water, then add 23 parts by weight of an aqueous polyurethane emulsion, and stir at 300 rpm for 20 minutes to obtain an antibacterial finishing agent; S4.2: preparing a non-woven fabric by mixing antibacterial viscose fiber and lyocell fiber in a ratio of 3:1, impregnating the non-woven fabric with an antibacterial finishing agent, and then ultrasonically treating the non-woven fabric at 30°C for 20 minutes, drying the non-woven fabric at 70°C for 3 minutes, and then drying the non-woven fabric at 35°C for 30 hours to obtain a pretreated non-woven fabric; S5: Preparation of antibacterial wipes S5.1: Mix 2 parts by weight of honeysuckle extract, 2 parts by weight of Centella asiatica extract, 1 part by weight of calcium pyrrolidonecarboxylate, 0.21 parts by weight of trehalose, 0.3 parts by weight of citric acid, 0.13 parts by weight of double-chain quaternary ammonium salt cetylpyridinium chloride, 1 part by weight of alkyl glucoside, and 100 parts by weight of deionized water to obtain a wet wipes solution; S5.2: The pretreated non-woven fabric is wetted with wet wipes liquid, wherein the weight ratio of the pretreated non-woven fabric to the wet wipes liquid is 1:2. After wetted with the liquid, the non-woven fabric is sterilized and packaged to obtain antibacterial wet wipes.

[0024] Example 2 A preparation process of antibacterial wet wipes containing plant extracts, such as Figure 1 As shown, the following steps are included: S1: Preparation of dialdehyde starch-catechin graft copolymer S1.1: Add 1.25 parts by weight of dialdehyde starch to 3.3 parts by weight of a 1 mol / L hydrochloric acid aqueous solution, and stir to obtain a dialdehyde starch solution; S1.2: Add 0.62 parts by weight of catechin to 6.7 parts by weight of dimethyl sulfoxide, and stir for 40 minutes to obtain a catechin solution; S1.3: Mix the dialdehyde starch solution and the catechin solution and react them in the dark at 45°C for 50 hours to obtain a reaction solution. The reaction solution is dialyzed against deionized water for 74 hours and then freeze-dried to obtain a dialdehyde starch-catechin graft copolymer. S2: Preparation of composite nanoparticles S2.1: Add 0.5 parts by weight of microcrystalline cellulose to 25 parts by weight of N,N-dimethylacetamide, stir and mix at 90°C for 30 minutes, then add 0.3 parts by weight of 6-bromohexanoyl chloride, react for 3 hours, then add 150 parts by weight of ethanol, stir for 2 hours, and then centrifuge to obtain an intermediate product; S2.2: 2 parts by weight of the intermediate product was added to N,N-dimethylacetamide to prepare a 25 mg / mL N,N-dimethylacetamide solution. The solution was then heated to 100°C and 5 parts by weight of N,N-dimethyltetradecylamine was added. The reaction was allowed to proceed for 5 h. The solution was then dialyzed against ethanol in a dialysis bag with a molecular weight cut-off of 3500. After the dialysis was complete, the solution was rotary evaporated to obtain the quaternized cellulose. S2.3: Adding quaternized cellulose to ethanol to prepare a 20 mg / mL ethanol solution, then adding citric acid and stirring to obtain a mixed solution, wherein the citric acid accounts for 50 wt % of the mixed solution. Transferring the mixed solution to a dialysis bag with a molecular weight cut-off of 3500 for dialysis. After the dialysis is complete, filtering to obtain composite nanoparticles; S3: Preparation of antibacterial viscose fiber S3.1: To 50 parts by weight of viscose spinning solution, 0.56 parts by weight of a 20 wt% collagen peptide solution, 0.92 parts by weight of a 10 wt% PVA solution, and 3 parts by weight of a dialdehyde starch-catechin graft copolymer were added and stirred for 30 minutes. The mixed blend was filtered and degassed to obtain a blended spinning solution; S3.2: The blended spinning solution was spun at a spinning speed of 16 m / min, a first roller speed of 14.825 m / min, a second roller speed of 22.196 m / min, a draft ratio of 1.6, a coagulation bath length of 2.0 m, and 65°C, followed by post-processing to produce an antibacterial viscose fiber. S4: Pretreatment of nonwoven fabrics S4.1: Add 13 parts by weight of composite nanoparticles and 5 parts by weight of sodium lauryl sulfate to 100 parts by weight of deionized water, then add 23 parts by weight of an aqueous polyurethane emulsion, and stir at 500 rpm for 30 minutes to obtain an antibacterial finishing agent; S4.2: preparing a non-woven fabric by mixing antibacterial viscose fiber and lyocell fiber in a ratio of 3:1, impregnating the non-woven fabric with an antibacterial finishing agent, and then ultrasonically treating the non-woven fabric at 50°C for 30 minutes, drying the non-woven fabric at 75°C for 5 minutes, and then drying the non-woven fabric at 40°C for 35 hours to obtain a pretreated non-woven fabric; S5: Preparation of antibacterial wipes S5.1: Mix 2 parts by weight of honeysuckle extract, 2 parts by weight of Centella asiatica extract, 1 part by weight of calcium pyrrolidonecarboxylate, 0.21 parts by weight of trehalose, 0.3 parts by weight of citric acid, 0.13 parts by weight of double-chain quaternary ammonium salt cetylpyridinium chloride, 1 part by weight of alkyl glucoside, and 100 parts by weight of deionized water to obtain a wet wipes solution; S5.2: The pretreated non-woven fabric is wetted with wet wipes liquid, wherein the weight ratio of the pretreated non-woven fabric to the wet wipes liquid is 1:2. After wetted with the liquid, the non-woven fabric is sterilized and packaged to obtain antibacterial wet wipes.

[0025] Example 3 A preparation process of antibacterial wet wipes containing plant extracts, such as Figure 1 As shown, the following steps are included: S1: Preparation of dialdehyde starch-catechin graft copolymer S1.1: Add 1.42 parts by weight of dialdehyde starch to 3.5 parts by weight of a 1 mol / L hydrochloric acid aqueous solution, and stir to obtain a dialdehyde starch solution; S1.2: Add 1.32 parts by weight of catechin to 8.2 parts by weight of dimethyl sulfoxide, and stir for 30 minutes to obtain a catechin solution; S1.3: Mix the dialdehyde starch solution and the catechin solution and react them in the dark at 40°C for 48 hours to obtain a reaction solution. The reaction solution is dialyzed against deionized water for 72 hours and then freeze-dried to obtain a dialdehyde starch-catechin graft copolymer. S2: Preparation of composite nanoparticles S2.1: Add 0.8 parts by weight of microcrystalline cellulose to 30 parts by weight of N,N-dimethylacetamide, stir and mix at 80°C for 20 minutes, then add 0.5 parts by weight of 6-bromohexanoyl chloride, react for 2 hours, then add 200 parts by weight of ethanol, stir for 1 hour, and then centrifuge to obtain an intermediate product; S2.2: 3 parts by weight of the intermediate product was added to N,N-dimethylacetamide to prepare a 25 mg / mL N,N-dimethylacetamide solution. The solution was then heated to 90°C and 8 parts by weight of N,N-dimethyltetradecylamine was added. The reaction was allowed to proceed for 4 h. The solution was then dialyzed against ethanol in a dialysis bag with a molecular weight cut-off of 3500. After completion of the dialysis, the solution was rotary evaporated to obtain the quaternized cellulose. S2.3: Adding quaternized cellulose to ethanol to prepare a 25 mg / mL ethanol solution, then adding citric acid and stirring to obtain a mixed solution, wherein the citric acid accounts for 50 wt % of the mixed solution. Transferring the mixed solution to a dialysis bag with a molecular weight cut-off of 3500 for dialysis. After the dialysis is complete, filtering to obtain composite nanoparticles; S3: Preparation of antibacterial viscose fiber S3.1: To 60 parts by weight of viscose spinning solution, 1.23 parts by weight of a 20 wt% collagen peptide solution, 1.39 parts by weight of a 10 wt% PVA solution, and 5 parts by weight of a dialdehyde starch-catechin graft copolymer were added and stirred for 20 minutes. The mixed blend was filtered and degassed to obtain a blended spinning solution; S3.2: The blended spinning solution was spun at a spinning speed of 15 m / min, a first roller speed of 14.825 m / min, a second roller speed of 22.196 m / min, a draft ratio of 1.4, a coagulation bath length of 1.8 m, and 65°C, followed by post-processing to produce an antibacterial viscose fiber. S4: Pretreatment of nonwoven fabrics S4.1: Add 15 parts by weight of composite nanoparticles and 8 parts by weight of sodium lauryl sulfate to 120 parts by weight of deionized water, then add 25 parts by weight of an aqueous polyurethane emulsion, and stir at 300 rpm for 20 minutes to obtain an antibacterial finishing agent; S4.2: preparing a non-woven fabric by mixing antibacterial viscose fiber and lyocell fiber in a ratio of 5:1, impregnating the non-woven fabric with an antibacterial finishing agent, and then ultrasonically treating the non-woven fabric at 30°C for 20 minutes, drying the non-woven fabric at 70°C for 3 minutes, and then drying the non-woven fabric at 35°C for 30 hours to obtain a pretreated non-woven fabric; S5: Preparation of antibacterial wipes S5.1: Mix 3 parts by weight of honeysuckle extract, 3 parts by weight of Centella asiatica extract, 2 parts by weight of calcium pyrrolidonecarboxylate, 0.42 parts by weight of trehalose, 0.5 parts by weight of citric acid, 0.15 parts by weight of double-chain quaternary ammonium salt cetylpyridinium chloride, 2 parts by weight of alkyl glucoside, and 120 parts by weight of deionized water to obtain a wet wipe solution; S5.2: The pretreated non-woven fabric is wetted with wet wipes liquid, wherein the weight ratio of the pretreated non-woven fabric to the wet wipes liquid is 1:4. After wetted with the liquid, the non-woven fabric is sterilized and packaged to obtain antibacterial wet wipes.

[0026] Comparative Example 1 Compared with Example 1, the difference of Comparative Example 1 is that the calcium pyrrolidone carboxylate in step S5 is removed in Comparative Example 1, and the other steps remain unchanged to prepare the antibacterial wipes, which is recorded as Comparative Example 1.

[0027] Comparative Example 2 Compared with Example 1, the difference of Comparative Example 2 is that the Centella asiatica extract in step S5 is removed in Comparative Example 2, and the other steps remain unchanged to prepare the antibacterial wipes, which is recorded as Comparative Example 2.

[0028] Comparative Example 3 Compared with Example 1, Comparative Example 3 is different in that step S1 is removed from Comparative Example 3, and the dialdehyde starch-catechin graft copolymer in step S3.1 is replaced with catechin. The other steps remain unchanged to prepare the antibacterial wipes, which is recorded as Comparative Example 3.

[0029] Comparative Example 4 Compared with Example 1, the difference of Comparative Example 4 is that the composite nanoparticles in step S2 and step S4.1 are removed in Comparative Example 4, and the other steps remain unchanged to prepare the antibacterial wipes, which is recorded as Comparative Example 4.

[0030] Antibacterial tests were performed on Examples 1-3 and Comparative Examples 1 and 3-4. The test results are shown in Table 1.

[0031] The bacterial strains were Staphylococcus aureus, Escherichia coli, Candida albicans, and Pseudomonas aeruginosa, mixed in a volume ratio of 1:1:1:1.

[0032] Table 1. Antibacterial test results of Examples 1-3 and Comparative Examples 1, 3-4

[0033] As can be seen from the data in Table 1, the antibacterial wipes prepared by the present invention exhibit significant antibacterial activity and have a broad-spectrum antibacterial effect. From the data in Comparative Example 1, it can be seen that the addition of calcium pyrrolidonecarboxylate can enhance the antibacterial effect. From the data in Comparative Example 3, it can be seen that the antibacterial ability can be improved by forming a stable structure through the grafting reaction of dialdehyde starch and catechin. From the data in Comparative Example 4, it can be seen that the composite nanoparticles can significantly enhance the antibacterial ability of the antibacterial wipes.

[0034] The antibacterial wipes prepared in Examples 1-3 and Comparative Example 3 were subjected to a 200 g / cm 2 Wipe back and forth 10 times to simulate the frequency of daily wiping. After wiping, perform the above antibacterial test again. The test results are shown in Table 2.

[0035] Table 2. Antibacterial test results after wiping

[0036] From the data in Table 2, it can be seen that a stable structure is formed by the grafting reaction of dialdehyde starch and catechin. After grafting, the antibacterial components are not easily lost due to friction, ensuring the long-term antibacterial effect of the wet wipes.

[0037] The redness and swelling soothing effect of the antibacterial wipes prepared in Examples 1-3 and Comparative Examples 1-2 was measured. 50 volunteers aged 20-50 years, 25 men and 25 women, were organized. Then, 5 areas were marked on the inside of the left and right arms of the volunteers to mark the test sites (4 cm × 4 cm). 5.0% capsaicin was used to stimulate the skin of the volunteers' arms, and three drops of capsaicin were dropped on the test sites to cause skin allergy and redness. Then, the antibacterial wipes prepared in Examples 1-3 and Comparative Examples 1 and 2 were used to repeatedly wipe one test site of the volunteer subjects 5 times. The test subjects were subjected to sensory evaluation 2 hours later. The measurement results are shown in Table 3.

[0038] Table 3. Results of redness and swelling relief effect

[0039] From the data in Table 3, it can be seen that the addition of calcium pyrrolidone carboxylate can achieve a synergistic soothing effect with Centella asiatica and achieve skin care.

[0040] The antibacterial wipes prepared in Examples 1-3 were subjected to a skin irritation test. Fifty volunteers aged 20-50 years, 25 men and 25 women, were recruited. Three test areas (4 cm × 4 cm) were marked on the inside of the left and right arms of the volunteers. The antibacterial wipes prepared in Examples 1-3 were then used to repeatedly wipe one test area of ​​each volunteer five times. The test subjects were observed after 12 hours. The observation results are shown in Table 4.

[0041] Table 4. Skin irritation test

[0042] As can be seen from Table 4, the antibacterial wet wipes prepared by the present invention are mild and non-irritating.

[0043] Determination of the grafting rate of dialdehyde starch-catechin graft copolymer: 1 mL of a 0.1 mg / mL aqueous solution of dialdehyde starch-catechin graft copolymer was reacted with 1 mL of Folin-Ciocalteu reagent (10-fold dilution) at 30°C in the dark for 5 min. 5 mL of saturated sodium carbonate solution was then added, and the mixture was reacted at 30°C in the dark for 2 h. The absorbance of the reaction mixture was measured at 760 nm. The grafting rate of the dialdehyde starch-catechin graft copolymer was calculated based on the catechin standard curve. The results were expressed as milligrams of catechin equivalent per gram of graft copolymer (mg / g). The grafting rate results are shown in Table 5.

[0044] Table 5. Grafting rate of dialdehyde starch-catechin graft copolymers of Examples 1-3

[0045] It can be seen from the data in Table 5 that the grafting rate of the dialdehyde starch-catechin graft copolymer prepared in the present invention is stable, and the dialdehyde starch-catechin graft copolymer can be successfully prepared.

[0046] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the present invention. Anyone skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by one of ordinary skill in the art without departing from the spirit and technical principles disclosed herein are intended to be covered by the claims of the present invention.

Claims

1. A process for preparing antibacterial wet wipes containing plant extracts, characterized in that: The steps include: S1: Preparation of dialdehyde starch-catechin graft copolymer S2: Preparation of composite nanoparticles Microcrystalline cellulose is reacted with 6-bromohexanoyl chloride to prepare an intermediate product, which is added to N,N-dimethylacetamide and then reacted with N,N-dimethyltetradecylamine to prepare quaternized cellulose, which is then compounded with citric acid to prepare composite nanoparticles; S3: Preparation of antibacterial viscose fiber Antibacterial viscose fibers were prepared by adding collagen peptide, PVA and dialdehyde starch-catechin graft copolymer into viscose spinning solution for spinning. S4: Pretreatment of nonwoven fabrics An antibacterial finishing agent is prepared by mixing composite nanoparticles, sodium dodecyl sulfate, deionized water and aqueous polyurethane emulsion, an antibacterial viscose fiber is mixed with lyocell fiber to prepare a non-woven fabric, and the non-woven fabric is impregnated in the antibacterial finishing agent to obtain a pretreated non-woven fabric; S5: Preparation of antibacterial wipes Honeysuckle extract, Centella asiatica extract, calcium pyrrolidonecarboxylate, trehalose, citric acid, double-chain quaternary ammonium salt, alkyl glucoside and deionized water are mixed to prepare a wet wipe liquid, and the pretreated non-woven fabric is lubricated with the wet wipe liquid to obtain an antibacterial wet wipe.

2. The process for preparing an antibacterial wet wipe containing a plant extract according to claim 1, wherein: Step S1: Preparation of dialdehyde starch-catechin graft copolymer, specifically comprising the following steps: S1.1: Add 1.25-1.42 parts by weight of dialdehyde starch to 3.3-3.5 parts by weight of a 1 mol / L hydrochloric acid aqueous solution, and stir to obtain a dialdehyde starch solution; S1.2: Add 0.62-1.32 parts by weight of catechin to 6.7-8.2 parts by weight of dimethyl sulfoxide, and stir for 30-40 minutes to obtain a catechin solution; S1.3: After mixing the dialdehyde starch solution and the catechin solution, react at 40-45° C. in the dark for 48-50 hours to obtain a reaction solution. The reaction solution is dialyzed against deionized water for 72-74 hours and then freeze-dried to obtain a dialdehyde starch-catechin graft copolymer.

3. The process for preparing an antibacterial wet wipe containing a plant extract according to claim 2, wherein: Step S2: Preparation of composite nanoparticles, specifically comprising the following steps: S2.1: Add 0.5-0.8 parts by weight of microcrystalline cellulose to 25-30 parts by weight of N,N-dimethylacetamide, stir and mix at 80-90°C for 20-30 minutes, then add 0.3-0.5 parts by weight of 6-bromohexanoyl chloride, react for 2-3 hours, then add 150-200 parts by weight of ethanol, stir for 1-2 hours, and then centrifuge to obtain an intermediate product; S2.2: 2-3 parts by weight of the intermediate product are added to N,N-dimethylacetamide to prepare a 25 mg / mL N,N-dimethylacetamide solution, which is then heated to 90-100°C. 5-8 parts by weight of N,N-dimethyltetradecylamine are then added. The reaction is carried out for 4-5 hours, followed by ethanol dialysis in a dialysis bag with a molecular weight cut-off of 3500. After dialysis, the solution is rotary evaporated to obtain the quaternized cellulose. S2.3: Add quaternized cellulose to ethanol to prepare a 20-25 mg / mL ethanol solution, then add citric acid and stir to obtain a mixed solution, wherein the citric acid accounts for 35-50 wt% of the mixed solution. Transfer the mixed solution to a dialysis bag with a molecular cutoff of 3500 for dialysis. After the dialysis is completed, filter to obtain composite nanoparticles.

4. The process for preparing an antibacterial wet wipe containing a plant extract according to claim 3, characterized in that: Step S3, preparation of antibacterial viscose fiber, specifically comprises the following steps: S3.1: Add 0.56-1.23 parts by weight of a 20 wt% collagen peptide solution, 0.92-1.39 parts by weight of a 10 wt% PVA solution, and 3-5 parts by weight of a dialdehyde starch-catechin graft copolymer to 50-60 parts by weight of a viscose spinning solution, stir and mix for 20-30 minutes, and filter and degas the mixed solution to obtain a blended spinning solution; S3.2: The blended spinning solution is spun at a spinning speed of 15-16 m / min, a first roller speed of 14.825 m / min, a second roller speed of 22.196 m / min, a drafting multiple of 1.4-1.6 times, a coagulation bath length of 1.8-2.0 m, and 60-65°C, and then post-processed to prepare antibacterial viscose fiber.

5. The process for preparing an antibacterial wet wipe containing a plant extract according to claim 4, characterized in that: Step S4: pre-treatment of the non-woven fabric, specifically comprising the following steps: S4.1: Add 13-15 parts by weight of composite nanoparticles and 5-8 parts by weight of sodium lauryl sulfate to 100-120 parts by weight of deionized water, then add 23-25 ​​parts by weight of an aqueous polyurethane emulsion, and stir at 300-500 rpm for 20-30 minutes to obtain an antibacterial finishing agent; S4.2: Antibacterial viscose fiber and lyocell fiber are mixed in a ratio of 3-5:1 to prepare a non-woven fabric, the non-woven fabric is immersed in an antibacterial finishing agent, and then ultrasonically treated at 30-50°C for 20-30 minutes, and then dried at 70-75°C for 3-5 minutes, and then dried at 35-40°C for 30-35 hours to obtain a pretreated non-woven fabric.

6. The process for preparing an antibacterial wet wipe containing a plant extract according to claim 5, characterized in that: Step S5: Preparation of antibacterial wipes, specifically comprising the following steps: S5.1: Mix 2-3 parts by weight of honeysuckle extract, 2-3 parts by weight of Centella asiatica extract, 1-2 parts by weight of calcium pyrrolidonecarboxylate, 0.21-0.42 parts by weight of trehalose, 0.3-0.5 parts by weight of citric acid, 0.13-0.15 parts by weight of a double-chain quaternary ammonium salt, 1-2 parts by weight of an alkyl glucoside, and 100-120 parts by weight of deionized water to obtain a wet wipes solution; S5.2: The pretreated non-woven fabric is wetted with a wet wipe liquid, sterilized after the wet treatment, and packaged to obtain antibacterial wet wipes.

7. The process for preparing an antibacterial wet wipe containing a plant extract according to claim 4, characterized in that: The weight ratio of the pretreated nonwoven fabric to the wet wipes liquid in step S5.2 is 1:2-4.

8. An antibacterial wet wipe containing plant extracts, characterized in that: The antibacterial wet wipes are prepared by the preparation process of the antibacterial wet wipes containing plant extracts according to claims 1-7.

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