Herbaceous plant collateral activating paste for promoting blood circulation to remove blood stasis and preparation method thereof

Abstract

The invention provides herbaceous plant collateral activating paste for promoting blood circulation to remove blood stasis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine agents.The herbaceous plant collateral activating paste is prepared from safflower carthamus, angelica sinensis, ligusticum wallichii, frankincense, pseudo-ginseng, turmeric, semen cassiae and myrrh. The safflower, the Chinese angelica, the szechuan lovage rhizome, the frankincense, the pseudo-ginseng, the turmeric and the myrrh are natural good medicines for promoting blood circulation and removing blood stasis, and can effectively promote blood circulation, dissipate blood stasis and relieve pain and swelling through mutual compatibility and synergistic interaction; the semen cassiae is rich in various components beneficial to skin, can assist other medicines in better playing roles, and has a certain nourishing effect on the skin; and through a method of combining alcohol extraction and water extraction, effective components in herbaceous plants are comprehensively extracted, so that the efficacy of the collateral activating ointment is ensured, the transdermal absorption efficiency of the collateral activating ointment is enhanced, and the medicine can reach a disease site more quickly to play a role.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and in particular to a herbal blood-activating and blood-stasis-removing ointment and a preparation method thereof. Background Art

[0002] In daily life, people will inevitably suffer from injuries, blood stasis, swelling and pain due to various reasons. They need effective drugs to promote blood circulation, dissipate blood stasis and relieve pain.

[0003] Although there are many Western medicine products for promoting blood circulation and removing blood stasis on the market, although they take effect quickly, they are accompanied by side effects, such as irritation to the gastrointestinal tract. Traditional Chinese medicine products for promoting blood circulation and removing blood stasis are mostly decoctions. Although they can be flexibly formulated according to individual differences, they are inconvenient to take, have a poor taste, and have low patient compliance. Summary of the Invention

[0004] The purpose of the present invention is to provide a herbal activating ointment for promoting blood circulation and removing blood stasis and a preparation method thereof, so as to solve the technical problems existing in the prior art.

[0005] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is:

[0006] A herbal activating paste for promoting blood circulation and removing blood stasis and a preparation method thereof are provided. The paste is prepared from the following raw materials: safflower, angelica, ligusticum chuanxiong, frankincense, notoginseng, turmeric, cassia seed and myrrh.

[0007] Furthermore, the weight of the raw materials is: safflower 15-40g, angelica 20-50g, chuanxiong 10-35g, frankincense 5-35g, panax notoginseng 18-35g, turmeric 15-35g, cassia seed 15-29g, and myrrh 30-75g.

[0008] Furthermore, the weight of the raw materials is: 25g of safflower, 35g of angelica, 20g of ligusticum, 18g of frankincense, 23g of Panax notoginseng, 18g of turmeric, 19g of cassia seed, and 45g of myrrh.

[0009] Furthermore, the invention comprises the following preparation method: S1: placing the processed raw materials of each flavor into an extraction tank, adding 60% to 70% ethanol solution at a total weight ratio of 1:8, sealing the extraction tank and heating it to 50-60°C, and reflux extraction once every 1-2 hours; filtering after each extraction, and collecting the filtered alcohol extract; S2: transferring the alcohol extract to a vacuum concentration device, and vacuum concentrating it at 55-65°C to a clear paste with a relative density of 1.15-1.35; S3: adding water 4-6 times the weight of the medicinal residue after alcohol extraction, heating it to 75-95°C, boiling it for 1.5-2.5 hours, and then filtering and collecting the water. S4: concentrating the water extract in S3 under reduced pressure at 65-75° C. to a concentrate with a relative density of 1.02-1.11; S5: mixing the clear paste and the water extract in S2 and S4 to form a mixed concentrate; S6: heating vaseline and beeswax to 85-95° C. and continuously stirring for 10-15 minutes, and then adding azone and continuing stirring for 20-30 minutes to form a matrix; S7: adding the mixed concentrate in S5 to the matrix, stirring at 55-65° C. and a speed of 250-350 r / min for 75-95 minutes to form a paste; S8: packaging the paste.

[0010] Compared with the prior art, the present invention has the following beneficial effects:

[0011] The safflower, angelica, ligusticum chuanxiong, frankincense, notoginseng, turmeric and myrrh in the present invention are all natural blood-activating and blood-stasis-removing medicines, which can effectively promote blood circulation, dissipate blood stasis and relieve pain and swelling through mutual compatibility and synergistic effect. The cassia seed is rich in multiple ingredients beneficial to the skin, which can assist other medicines to better exert their effects and has a certain nourishing effect on the skin. In addition, the effective ingredients in the herbal plants are fully extracted through the method of combining alcohol extraction and water extraction, thereby ensuring the efficacy of the active ointment and enhancing the transdermal absorption efficiency of the present invention, so that the medicine can reach the diseased area faster and exert its effect. DETAILED DESCRIPTION

[0012] In order to make the purpose, technical solution and technical effect of the present invention more clear, the specific embodiments of the present invention are described below. It should be understood that the specific embodiments described here are only used to explain the present invention and are not used to limit the present invention.

[0013] This embodiment provides a herbal herbal ointment for promoting blood circulation and removing blood stasis and a preparation method thereof, which is made from the following raw materials: safflower, angelica, ligusticum, frankincense, Panax notoginseng, turmeric, cassia seed, and myrrh. The specific effects are as follows:

[0014] Safflower: Pungent in taste and warm in nature, it enters the Heart and Liver meridians. It is a classic medicine for promoting blood circulation and removing blood stasis. It can promote blood circulation, unblock menstruation, disperse blood stasis and relieve pain.

[0015] Angelica sinensis: sweet, spicy, warm in nature, enters the liver, heart, and spleen meridians. It can nourish blood and promote blood circulation, regulate menstruation and relieve pain, and moisten the intestines and promote bowel movements.

[0016] Chuanxiong: spicy, warm in nature, enters the liver, gallbladder, and pericardium meridians, and has the effects of promoting blood circulation, promoting qi, dispelling wind and relieving pain;

[0017] Frankincense: pungent, bitter, warm in nature, enters the heart, liver, and spleen meridians, can promote blood circulation, relieve pain, reduce swelling and promote tissue regeneration;

[0018] Panax notoginseng: sweet, slightly bitter, warm in nature, enters the liver and stomach meridians, has the effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain;

[0019] Turmeric: pungent, bitter, warm in nature, enters the liver and spleen meridians, can break up blood and promote qi circulation, and relieve menstruation and pain;

[0020] Cassia seed: It tastes sweet, bitter, and salty, and is slightly cold in nature. It enters the liver and large intestine meridians, regulating liver function, thereby achieving the effects of clearing the liver and purging fire, improving eyesight and removing cataracts.

[0021] Myrrh: pungent and bitter in taste, neutral in nature, enters the heart, liver, and spleen meridians, can disperse blood stasis, relieve pain, reduce swelling and promote tissue regeneration, and enhance the effects of promoting blood circulation, relieving pain, reducing swelling and promoting tissue regeneration;

[0022] Example 1:

[0023] The weight of the raw materials is: 15g of safflower, 20g of angelica, 10g of ligusticum, 5g of frankincense, 18g of panax notoginseng, 15g of turmeric, 15g of cassia seed, and 30g of myrrh;

[0024] S1: placing the processed raw materials of each flavor into an extraction tank, adding 60% ethanol solution at a total weight ratio of 1:8, wherein the ethanol solution can effectively dissolve the alkaloids, flavonoids, terpenes and other active ingredients in the raw materials of each flavor, sealing the extraction tank and heating it to 50°C, and performing reflux extraction once every 1 hour. The reflux extraction can allow the solvent to evaporate after heating and then flow back to the extraction tank after condensation, constantly contacting the raw materials, thereby fully extracting the active ingredients therein; filtering after each extraction, and collecting the filtered alcohol extract; the above-mentioned processing method is: removing impurities from safflower, angelica, Chuanxiong, frankincense, Panax notoginseng, turmeric, cassia seed, and myrrh, washing and drying them, and slicing or cutting them to ensure that the active ingredients can be fully dissolved in the subsequent extraction process;

[0025] S2: The alcohol extract was transferred to a vacuum concentration device and concentrated under reduced pressure at 55°C to a thick clear paste with a relative density of 1.15;

[0026] S3: Add 4 times the weight of the medicinal residue to the alcohol-extracted residue in water, heat to 75°C, and boil for 1.5 hours to allow the water and the medicinal residue to fully contact and dissolve the water-soluble active ingredients in the water. Then filter and collect the water extract;

[0027] S4: The water extract in S3 is concentrated under reduced pressure at 65° C. to a concentrate with a relative density of 1.02. The concentrate retains the water-soluble active ingredients in the medicinal residue and can complement the alcohol-extracted clear paste;

[0028] S5: Mixing the clear paste and water extract in S2 and S4, and continuously adding water and stirring during the mixing process to ensure that the two can be fully blended to form a mixed concentrate;

[0029] S6: heating vaseline and beeswax to 85° C. and stirring continuously for 10 minutes, and then adding azone and stirring continuously for 20 minutes to form a matrix; the azone is a highly effective penetration enhancer that can significantly enhance the transdermal absorption of the drug;

[0030] S7: adding the mixed concentrate in S5 to the base, stirring at 250 rpm at 55°C for 75 minutes to form a paste with a uniform and fine texture;

[0031] S8: Conduct a comprehensive inspection on various indicators of the paste, and package the paste that passes the inspection.

[0032] How to use: Apply directly to the painful or uncomfortable area as needed, and gently massage until completely absorbed; use 2-3 times a day, and one week of continuous use is a course of treatment. The symptoms will be alleviated in one course of treatment, and the symptoms will disappear completely after three courses of treatment.

[0033] Example 2:

[0034] The weight of the raw materials is: 40g of safflower, 50g of angelica, 35g of chuanxiong, 35g of frankincense, 35g of panax notoginseng, 35g of turmeric, 29g of cassia seed, and 75g of myrrh;

[0035] S1: placing the processed raw materials of each flavor into an extraction tank, adding 65% ethanol solution at a total weight ratio of 1:8, wherein the ethanol solution can effectively dissolve the alkaloids, flavonoids, terpenes and other active ingredients in the raw materials of each flavor, sealing the extraction tank and heating it to 55°C, and performing reflux extraction once every 1.5 hours. The reflux extraction can make the solvent evaporate after heating and then flow back to the extraction tank after condensation, constantly contacting with the raw materials, thereby fully extracting the active ingredients therein; filtering after each extraction, and collecting the filtered alcohol extract; the above-mentioned processing method is: removing impurities from safflower, angelica, Chuanxiong, frankincense, Panax notoginseng, turmeric, cassia seed, and myrrh, washing and drying them, and slicing or cutting them to ensure that the active ingredients can be fully dissolved in the subsequent extraction process;

[0036] S2: The alcohol extract is transferred to a vacuum concentration device and concentrated under reduced pressure at 60°C to a thick clear paste with a relative density of 1.25;

[0037] S3: Add 5 times the weight of the medicinal residue to the alcohol-extracted residue in water, heat to 90°C, and boil for 2 hours to allow the water and the medicinal residue to fully contact and promote the dissolution of the water-soluble active ingredients in the water. Then filter and collect the water extract;

[0038] S4: Concentrating the water extract in S3 under reduced pressure at 70° C. to a concentrate with a relative density of 1.05. The concentrate retains the water-soluble active ingredients in the medicinal residue and can complement the alcohol-extracted clear paste;

[0039] S5: Mixing the clear paste and water extract in S2 and S4, and continuously adding water and stirring during the mixing process to ensure that the two can be fully blended to form a mixed concentrate;

[0040] S6: heating vaseline and beeswax to 90° C. and stirring continuously for 13 minutes, and then adding azone and stirring continuously for 25 minutes to form a matrix; the azone is a highly effective penetration enhancer that can significantly enhance the transdermal absorption of the drug;

[0041] S7: adding the mixed concentrate in S5 to the base, stirring at 290 rpm at 60° C. for 85 min to form a paste with uniform and fine texture;

[0042] S8: Conduct a comprehensive inspection on various indicators of the paste, and package the paste that passes the inspection.

[0043] How to use: Apply directly to the painful or uncomfortable area as needed, and gently massage until completely absorbed; use 2-3 times a day, and one week of continuous use is a course of treatment. The symptoms will be alleviated in one course of treatment, and the symptoms will disappear completely after three courses of treatment.

[0044] Example 3:

[0045] The weight of the raw materials is: 25g of safflower, 35g of angelica, 20g of ligusticum, 18g of frankincense, 23g of panax notoginseng, 18g of turmeric, 19g of cassia seed, and 45g of myrrh;

[0046] S1: placing the processed raw materials of each flavor into an extraction tank, adding 70% ethanol solution at a total weight ratio of 1:8, wherein the ethanol solution can effectively dissolve the alkaloids, flavonoids, terpenes and other active ingredients in the raw materials, sealing the extraction tank and heating it to 60°C, and performing reflux extraction once every 2 hours. The reflux extraction can allow the solvent to evaporate after heating and then flow back into the extraction tank after condensation, constantly contacting the raw materials, thereby fully extracting the active ingredients therein; filtering after each extraction, and collecting the filtered alcohol extract; the above-mentioned processing method is: removing impurities from safflower, angelica, Chuanxiong, frankincense, Panax notoginseng, turmeric, cassia seed, and myrrh, washing and drying them, and slicing or cutting them to ensure that the active ingredients can be fully dissolved in the subsequent extraction process;

[0047] S2: The alcohol extract is transferred to a vacuum concentration device and concentrated under reduced pressure at 55-65°C to a thick clear paste with a relative density of 1.35;

[0048] S3: Add 6 times the weight of the medicinal residue to the alcohol-extracted residue in water, heat to 95°C, and boil for 2.5 hours to allow the water and the medicinal residue to fully contact and promote the dissolution of the water-soluble active ingredients in the water. Then filter and collect the water extract;

[0049] S4: Concentrating the water extract in S3 under reduced pressure at 75° C. to a concentrate with a relative density of 1.11. The concentrate retains the water-soluble active ingredients in the medicinal residue and can complement the alcohol-extracted clear paste;

[0050] S5: Mixing the clear paste and water extract in S2 and S4, and continuously adding water and stirring during the mixing process to ensure that the two can be fully blended to form a mixed concentrate;

[0051] S6: heating vaseline and beeswax to 95° C. and stirring continuously for 15 minutes, and then adding azone and stirring continuously for 30 minutes to form a matrix; the azone is a highly effective penetration enhancer that can significantly enhance the transdermal absorption of the drug;

[0052] S7: adding the mixed concentrate in S5 to the base, stirring at 350 rpm at 65°C for 95 minutes to form a paste with uniform and fine texture;

[0053] S8: Conduct a comprehensive inspection on various indicators of the paste, and package the paste that passes the inspection.

[0054] How to use: Apply directly to the painful or uncomfortable area as needed, and gently massage until completely absorbed; use 2-3 times a day, and one week of continuous use is a course of treatment. The symptoms will be alleviated in one course of treatment, and the symptoms will disappear completely after three courses of treatment.

[0055] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the scope of protection of the present invention.

Claims

1. A herbal activating paste for promoting blood circulation and removing blood stasis, characterized by: It is made from the following ingredients: safflower, angelica, chuanxiong, frankincense, Panax notoginseng, turmeric, cassia seed, and myrrh.

2. The herbal plaster for promoting blood circulation and removing blood stasis according to claim 1, characterized in that: The weight of the raw materials is as follows: 15-40g of safflower, 20-50g of angelica, 10-35g of chuanxiong, 5-35g of frankincense, 18-35g of panax notoginseng, 15-35g of turmeric, 15-29g of cassia seed, and 30-75g of myrrh.

3. The herbal plaster for promoting blood circulation and removing blood stasis according to claim 2, characterized in that: The weight of the raw materials is: 25g of safflower, 35g of angelica, 20g of chuanxiong, 18g of frankincense, 23g of panax notoginseng, 18g of turmeric, 19g of cassia seed, and 45g of myrrh.

4. The herbal activating blood circulation and stasis-removing ointment according to any one of claims 1 to 3 and its preparation method, characterized in that: The invention comprises the following preparation methods: S1: Place the processed raw materials of each flavor into an extraction tank, add 60% to 70% ethanol solution at a total weight ratio of 1:8, seal the extraction tank and heat it to 50-60°C, and reflux extraction once every 1-2 hours; Filter after each extraction and collect the filtered alcohol extract; S2: The alcohol extract is transferred to a vacuum concentration device and concentrated under reduced pressure at 55-65°C to a clear paste with a relative density of 1.15-1.35; S3: Add 4-6 times the weight of the medicinal residue after alcohol extraction into water, heat to 75-95°C, boil for 1.5-2.5 hours, and then filter and collect the water extract; S4: Concentrating the aqueous extract in S3 under reduced pressure at 65-75° C. to a concentrate having a relative density of 1.02-1.11; S5: mixing the clear paste and water extract in S2 and S4 to form a mixed concentrate; S6: Heat the vaseline and beeswax to 85-95°C and continue stirring for 10-15 minutes, then add azone and continue stirring for 20-30 minutes to form a matrix; S7: adding the mixed concentrate in S5 to the base, stirring at 250-350 rpm for 75-95 minutes at 55-65°C to form a paste; S8: Packing the paste.