Use of a bmp9 inhibitor in the manufacture of a medicament for the treatment of hypertension

By constructing a BMP9 gene knockout rat model using CRISPR/Cas9 technology, the problem of difficulty in assessing the impact of BMP9 deficiency on hypertension in existing technologies has been solved. This demonstrates the effectiveness of BMP9 inhibitors in the treatment of hypertension, reducing blood pressure elevation and improving vascular dysfunction, and provides a new strategy for the development of hypertension drugs.

CN120586063BActive Publication Date: 2026-06-23THE SIXTH MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL +1
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Patent Information

Application Number
CN202510812810.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-06-18
Publication Date
2026-06-23
Estimated Expiration
2045-06-18

AI Technical Summary

Technical Problem

Existing animal models of hypertension lack precise regulation of specific gene functions, making it difficult to deeply analyze the role of gene-environment interactions in the development of hypertension. Furthermore, there is a lack of specific knockout rat models of the BMP9 gene, making it impossible to directly assess the impact of BMP9 deficiency on AngII-induced hypertension and explore its potential as a target for antihypertensive therapy.

Method used

A BMP9 gene knockout rat model was constructed using CRISPR/Cas9 technology. By targeting the BMP9 gene with sgRNA and using the Cas9 nuclease to cleave exon 1 and exon 2, the function of the BMP9 gene was lost. Cas9 and sgRNA were then injected into rat zygotes using microinjection technology to establish the BMP9 deletion model and verify the effectiveness of the BMP9 inhibitor.

Benefits of technology

The BMP9 knockout rat model showed that BMP9 deficiency can alleviate AngII-induced hypertension and vascular dysfunction, and improve vascular remodeling, providing new tools and ideas for the study of the pathogenesis of hypertension and drug development, and demonstrating the effectiveness of BMP9 inhibitors in the treatment of hypertension.

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Abstract

The application discloses application of a BMP9 inhibitor in preparation of a medicine for treating hypertension. It is found for the first time that knocking out BMP9 can reduce the blood pressure rise, vascular dysfunction and vascular remodeling phenomenon induced by AngII, that is, the BMP9 inhibitor can be used in effective treatment of hypertension, has a good application prospect and medicine development value in the technical field of hypertension treatment, and provides a brand-new thought and strategy for research and development of a hypertension treatment medicine.
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