Macrocyclic compound as well as preparation method and application thereof

Abstract

Compounds represented by formula (I) or stereoisomers thereof, or pharmaceutically acceptable salts, solvates or prodrugs thereof, in which the definition of each group is described in the specification, pharmaceutical compositions containing the compounds and their use in the preparation of drugs for prevention and / or treatment of RAS protein activity-related diseases or disorders (e.g., cancers) are provided, as well as pharmaceutical compositions containing the compounds and their use in the preparation of drugs for prevention and / or treatment of RAS protein activity-related diseases or disorders (e.g., cancers).

Description

Macrocyclic compound and its preparation method and use

[0001] The present invention belongs to the field of medicine, and in particular relates to a macrocyclic compound capable of inhibiting RAS protein, and a preparation method and use thereof.

[0002] The RAS gene (Rat sarcoma viral oncogene homolog) encodes a family of small GTP hydrolase proteins with a molecular weight of approximately 21 kDa. The mammalian RAS family includes three members: HRAS, KRAS, and NRAS. They function as molecular switches in the signaling pathways of various cellular pathways. When bound to GDP, RAS is in a dormant or inactive state. When cells are exposed to certain growth-promoting stimuli, RAS is induced to exchange the bound GDP for GTP, thereby becoming activated. It then recruits and activates other downstream target proteins (such as Raf and PI3K), promoting cell proliferation. RAS proteins inherently have the ability to hydrolyze GTP to GDP (thus converting themselves to an inactive state), but the conversion rate is low. However, when bound to GTPase-activating proteins (GAPs), the interaction greatly accelerates the rate at which RAS proteins convert GTP to GDP, allowing them to rapidly return to their inactive state upon termination of cellular stimulation and shut down signaling pathways.

[0003] Approximately 30% of human tumors harbor RAS gene mutations; KRAS mutations are the most common, accounting for approximately 85%, followed by NRAS and HRAS at 12% and 3%, respectively. KRAS mutations are predominant in pancreatic cancer (86%), colorectal cancer (41%), and lung cancer (32%). NRAS mutations are more common in melanoma and acute myeloid leukemia, and HRAS mutations are more common in bladder cancer and head and neck cancer. In tumors, RAS gene mutations primarily occur through point mutations. Over 150 different RAS point mutations have been identified, with mutations at positions G12 and G13, as well as Q61, being the most common. These pathogenic mutations typically affect the interaction between RAS and GAP and the endogenous GTP hydrolase activity of RAS, resulting in the mutant RAS protein being primarily present in the GTP-bound, activated form within the cell. This results in the RAS protein maintaining a persistently activated signaling pathway, leading to uncontrolled cell proliferation and ultimately promoting tumor formation.

[0004] Currently, the targeted drugs AMG510 and MRTX849 have been approved for the treatment of KRAS G12C mutation-positive non-small cell lung cancer. However, there are no approved targeted drugs for KRAS G12D and KRAS G12V mutations, which are frequently seen in pancreatic and colorectal cancers, or for NRAS and HRAS mutations, which are common in melanoma and head and neck cancers. Therefore, the development of highly effective inhibitors targeting multiple RAS mutations holds significant clinical value and represents both a hot topic and a challenge in the field of new drug development.

[0005]

[0006] The present invention provides a class of RAS inhibitors. The RAS inhibitors of the present invention have the advantages of high activity, low toxicity and side effects, and good physical and chemical properties and drug-forming properties.

[0007] The first aspect of the present invention provides a compound represented by formula (I8) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0008] Where,

[0009] for

[0010] X is

[0011] Y1 is N, CH, or CR 4a , CR 4b or CR5; where N can be oxidized (N + -O - );

[0012] Y2 is N, CH, or CR 4a , CR 4b or CR5; where N can be oxidized (N + -O - );

[0013] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0014] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0015] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0016] R 00 is hydrogen or C 1-6 alkyl;

[0017] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0018] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0019] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0020] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, or -P(=O)-(C 1-6 Alkyl)2;

[0021] R 4a is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0022] R 4b is deuterium, halogen, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0023] R5 is hydrogen, -NR 01 R 02 、-C(R05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C1-4 Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkenyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R05 )R 03 R 04 );

[0024] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 alkyl)3-Si-; or,

[0025] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or

[0026] R 01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0027] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0028] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0029] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C1-6 alkyl;

[0030] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0031] Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkyl-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0032] or Y3, R 12 Together with the nitrogen atom to which they are attached, they form a substituted or unsubstituted nitrogen-containing 3- to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0033] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0034] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0035] R07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0036] R 08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0037] or R 07 and R 08 Together with the atoms to which it is attached, it forms a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0038] Y5 is O or S;

[0039] Y4 is O or S;

[0040] R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl or -P(=O)-(C 1-6 Alkyl)2; R 14 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl or -P(=O)-(C 1-6 alkyl)2; or

[0041] R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0042] In each of the above groups, the substitution independently refers to the above groups being independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from Group S1; the groups of Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-hydroxyl, -OC 1-4 Alkyl-cyano, -OC 1-4 Alkyl-C 1-6 Alkyl, -OC 1-4 Alkyl-C 1-6 Alkoxy, -OC 1-4 Alkyl-C 3-20Cycloalkyl, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl, -OC 1-4 Alkyl-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-C 6-14 Aryl, -OC 1- 4-alkyl-OC 6-14 Aryl, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1- 4-alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1- 6-alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6-14aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1-S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-N=S(=O)(R g1 )(R h1 )、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2; the nitrogen atom in the 5- or 6-membered monocyclic heteroaryl group may be optionally oxidized (N + -O - );

[0043] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0044] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0045] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0046] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0047] In the above groups, R g1 、R h1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R g1 、R h1 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0048] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, cyano, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0049] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR eR f replace;

[0050] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0051] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0052] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the aryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0053] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0054] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR eThe group substituted; R e Same definition as above.

[0055] In the present invention, when R6 is dimethylcyclopropyl, Y4 is O, Y5 is O, R1 and R2 are hydrogen, L1 is thiazole, R 42 、R 43 is methyl, R 13 、R 14 When R3 is ethyl, R5 is not methylpiperazinyl.

[0056] In one embodiment, for

[0057] In one embodiment, for Further Further

[0058] In one embodiment, Y1 is N, CH, CR 4a , CR 4b or CR5; where N can be oxidized (N + -O - ).

[0059] In one embodiment, Y1 is N.

[0060] In one embodiment, Y1 is N or CH; wherein N can be oxidized (N + -O - ).

[0061] In one embodiment, Y2 is N, CH, CR 4a , CR 4b or CR5; where N can be oxidized (N + -O - ).

[0062] In one embodiment, Y2 is CH or CR 4b ; Among them, R 4b is deuterium, halogen, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 1-6 Heteroalkyl.

[0063] In one embodiment, Y2 is CH.

[0064] In one embodiment, R 42 is methyl; R 43It is a methyl group.

[0065] In one embodiment, R 42 and R 43 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted cyclopropyl group.

[0066] In one embodiment, L1 is thiazole.

[0067] In one embodiment, R1 is hydrogen; R2 is hydrogen.

[0068] In one embodiment, R3 is a substituted or unsubstituted C 1-6 alkyl.

[0069] In one embodiment, R3 is unsubstituted C 1-6 Alkyl or halogenated C 1-6 alkyl.

[0070] In one embodiment, R 4a is substituted or unsubstituted C 1-6 alkyl.

[0071] In one embodiment, R 4a C substituted with hydroxy or methoxy 1-6 alkyl.

[0072] In one embodiment, R5 is -C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4Alkyl-NR 01 R 02 ;

[0073] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 alkyl)3-Si-; or,

[0074] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or

[0075] R 01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0076] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0077] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0078] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C1-6 alkyl.

[0079] In one embodiment, R5 is -C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 ;

[0080] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl; or

[0081] R 01 、R 02Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted azetidinyl, a substituted or unsubstituted oxazepanyl, a substituted or unsubstituted dioxepanyl, a substituted or unsubstituted morpholinyl, a substituted or unsubstituted pyrrolidinyl, a substituted or unsubstituted piperidinyl, a substituted or unsubstituted piperazinyl, a substituted or unsubstituted 3-oxa-8-azabicyclo[3.2.1]octyl, a substituted or unsubstituted tetrahydro-1H-pyrrolazinyl, a substituted or unsubstituted thiomorpholinyl, a substituted or unsubstituted tetrahydro-5H-pyrazolo[4,3-c]pyridinyl, a substituted or unsubstituted 1,2,5-diazadiazepanyl, a substituted or unsubstituted 1,4-thiazepanyl, a substituted or unsubstituted 3,8-diazabicyclo[3.2.1]octyl, or a substituted or unsubstituted 4-oxa-7-azaspiro[2.5]octyl group;

[0082] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted azetidinyl, a substituted or unsubstituted oxazepanyl, a substituted or unsubstituted dioxepanyl, a substituted or unsubstituted morpholinyl, a substituted or unsubstituted pyrrolidinyl, a substituted or unsubstituted piperidinyl, a substituted or unsubstituted piperazinyl, a substituted or unsubstituted 3-oxa-8-azabicyclo[3.2.1]octyl, a substituted or unsubstituted tetrahydro-1H-pyrrolazine substituted or unsubstituted thiomorpholinyl, substituted or unsubstituted tetrahydro-5H-pyrazolo[4,3-c]pyridinyl, substituted or unsubstituted 1,2,5-dithiadiazepanyl, substituted or unsubstituted 1,4-thiazepanyl, substituted or unsubstituted 3,8-diazabicyclo[3.2.1]octyl, substituted or unsubstituted 4-oxa-7-azaspiro[2.5]octyl, substituted or unsubstituted cyclobutyl;

[0083] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl.

[0084] In one embodiment, R5 is -C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C 2-4Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 or -C 2-4 Alkynyl-C(R 05 )R 03 R 04 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0085] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0086] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0087] R 06 is hydrogen, deuterium or C 1-6 alkyl.

[0088] In one embodiment, R5 is -C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group.

[0089] In one embodiment, R5 is -C 2-4 Alkynyl-NR01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group.

[0090] In one embodiment, R5 is -C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group.

[0091] In one embodiment, R5 is -C 2-4 Alkynyl-C(R 05 )R 03 R 04 ; R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group; R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl.

[0092] In one embodiment, R5 is -C 2-4 Alkynyl-C(R 05 )R 03 R 04 ; R 03 、R 04Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group; R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl.

[0093] In one embodiment, R5 is -C 2-4 Alkynyl-C(R 05 )R 03 R 04 ; R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl.

[0094] In one embodiment, R5 is -C 2-4 Alkynyl-C(R 05 )R 03 R 04 ; R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl group or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group; R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl.

[0095] In one embodiment, R5 is -OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl;

[0096] R01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 alkyl)3-Si-; or,

[0097] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or

[0098] R 01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0099] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0100] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0101] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0102] R 06 is hydrogen, deuterium or C1-6 alkyl.

[0103] In one embodiment, R5 is -OC 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group.

[0104] In one embodiment, R5 is -OC 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group.

[0105] In one embodiment, R5 is -OC 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group.

[0106] In one embodiment, R5 is -OC 1-4 Alkyl-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group.

[0107] In one embodiment, R5 is -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group.

[0108] In one embodiment, R5 is -OC 1-4 Alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group.

[0109] In one embodiment, R5 is -C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1- 4-alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-CH=CR 01 R 02 、-C 2-4 Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkenyl-C 1-4 Alkyl-C(R 05 )R 03 R 04、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C=CR 03 R 04 、-N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );

[0110] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 alkyl)3-Si-; or,

[0111] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or

[0112] R01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0113] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0114] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0115] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0116] R 06 is hydrogen, deuterium or C 1-6 alkyl.

[0117] In one embodiment, R5 is -NR 01 R 02 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4Alkyl-C(R 05 )R 03 R 04 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-CH=CR 01 R 02 ;or,

[0118] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0119] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0120] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0121] R 06 is hydrogen, deuterium or C 1-6 alkyl.

[0122] In one embodiment, R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group.

[0123] In one embodiment, R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group.

[0124] In one embodiment, R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group.

[0125] In one embodiment, Y3 is -C(=O)R6; R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl.

[0126] In one embodiment, Y3 is R 11 ; R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl.

[0127] In one embodiment, R 12 For hydrogen.

[0128] In one embodiment, Y5 is O; Y4 is O.

[0129] In one embodiment, R 13 is hydrogen; R 14 For hydrogen.

[0130] In one embodiment, in each group described herein, the substitution each independently means that the above group is each independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from Group S1.

[0131] In one embodiment, the groups of group S1 are each independently selected from the group consisting of deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-8 Cycloalkyl, 3 to 8 membered heterocyclic group, phenyl, 5 or 6 membered monocyclic heteroaryl, 8 to 10 membered bicyclic heteroaryl, -OC 3-8 Cycloalkyl, -O-3 to 8-membered heterocyclic group, -O-phenyl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-8Cycloalkyl, -C≡C-3 to 8-membered heterocyclic group, -C≡C-phenyl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡C- 1-4 Alkyl-C 3-8 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 8-membered heterocyclic group, -C≡CC 1-4 Alkyl-phenyl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-8 Cycloalkyl, -C 1-4 Alkyl-OC 3-8 Cycloalkyl, -C 1-4 Alkyl-3 to 8 membered heterocyclic group, -C 1-4 Alkyl-O-3 to 8-membered heterocyclic group, -C 1-4 Alkyl-phenyl, -C 1-4 Alkyl-O-phenyl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-hydroxyl, -OC 1-4 Alkyl-cyano, -OC 1-4 Alkyl-C 1-6 Alkyl, -OC 1-4 Alkyl-C 1-6 Alkoxy, -OC 1-4 Alkyl-C 3-8 Cycloalkyl, -OC 1-4 Alkyl-OC 3-8 Cycloalkyl, -OC 1-4 Alkyl-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-phenyl, -OC 1-4 Alkyl-O-phenyl, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -OC1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-8 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3- 8-cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-8 Cycloalkyl, -C(=O)-phenyl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-8 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-8 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-8 Cycloalkyl, -C 1- 4-alkyl-C(=O)-phenyl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-8 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 8-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-phenyl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-N=S(=O)(R g1 )(R h1 )、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-8The cycloalkyl, the 3 to 8 membered heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2; the nitrogen atom in the 5 or 6 membered monocyclic heteroaryl may be optionally oxidized (N + -O - ).

[0132] In one embodiment, the groups of group S1 are each independently selected from the following groups: oxo (=O), thio (=S), ═CR e R f 、=NR e , halogen, cyano, hydroxyl, C 1-6 Alkyl, C 1-6 Alkoxy, phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -C(=O)OC 1-6 Alkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-NR a1 R b1 、-N=S(=O)(R g1 )(R h1 )、-P(=O)-(C 1-6 alkyl)2, -C(=O)-C 1-4 Alkyl-hydroxy, -C(=O)-C 1-4 Alkyl-cyano; wherein the C 1-6 The alkyl group is optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxyl; the phenyl group, the 5 or 6-membered monocyclic heteroaryl group is optionally substituted by 1, 2, 3 or 4 groups selected from Group S2; the nitrogen atom in the 5 or 6-membered monocyclic heteroaryl group may be optionally oxidized (N + -O - ).

[0133] In one embodiment, in each group described herein, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2.

[0134] In one embodiment, in each group described herein, each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2.

[0135] In one embodiment, in each group described herein, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0136] In one embodiment, in each group described herein, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2.

[0137] In one embodiment, among the groups described herein, R g1 、R h1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R g1 、R h1 Together with the connected sulfur atom, they form a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group.

[0138] In one embodiment, among the groups described herein, the groups of each S2 group are independently selected from the group consisting of deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, cyano, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5.

[0139] In one embodiment, in the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace.

[0140] In one embodiment, in the above groups, the -C 1-4 Alkyl- is unsubstituted.

[0141] In one embodiment, in the above groups, the -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from C 1-4 Alkyl, halogenated C 1-4 Alkyl, deuterated C 1-4 substituted with an alkyl group.

[0142] In one embodiment, in the above groups, the C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group wherein j is 2, 3, 4, 5 or 6.

[0143] In one embodiment, in the above groups, the C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace.

[0144] In one embodiment, among the groups described herein, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl. Further R e are each independently H or halogen.

[0145] In one embodiment, among the groups described herein, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl. Further R f are each independently H or halogen.

[0146] In one embodiment, in each group described herein, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclyl, 3- to 10-membered heterocyclyl, or 3- to 8-membered monocyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0147] In one embodiment, in each group described herein, the C 1-6 One or more (eg, 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0148] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0149] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0150] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0151] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, or 4) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0152] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, 4, or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0153] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0154] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl is a heteroatom selected from nitrogen, oxygen, sulfur, or phosphorus.

[0155] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0156] In one embodiment, in each group described herein, one or more (eg, 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus.

[0157] In one embodiment, in each group described herein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

[0158] In one embodiment, in each group described herein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above.

[0159] The first aspect of the present invention provides a compound represented by formula (I7) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0160] Where,

[0161] X is

[0162] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0163] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0164] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0165] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0166] L1 is -N(R 00)C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0167] R 00 is hydrogen or C 1-6 alkyl;

[0168] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0169] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0170] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0171] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0172] R 4a is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0173] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06)C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkenyl-C 1-4 Alkyl-C(R 05)R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );

[0174] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0175] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0176] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0177] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0178] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0179] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0180] Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkyl-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C1-4 Alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0181] or Y3, R 12 Together with the nitrogen atom to which they are attached, they form a substituted or unsubstituted nitrogen-containing 3- to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0182] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0183] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0184] R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0185] R 08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0186] Y5 is O or S;

[0187] Y4 is O or S;

[0188] R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 14 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0189] R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0190] In each of the above groups, the substitution independently refers to the above groups being independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from Group S1; the groups of Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-hydroxyl, -OC 1-4 Alkyl-cyano, -OC 1-4 Alkyl-C 1-6 Alkyl, -OC 1-4 Alkyl-C 1-6 Alkoxy, -OC 1-4 Alkyl-C 3-20 Cycloalkyl, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl, -OC 1-4 Alkyl-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-C 6-14 Aryl, -OC 1- 4-alkyl-OC 6-14 Aryl, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NRa1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1- 4-alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1- 6-alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2- 6 alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0191] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0192] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0193] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0194] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0195] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl) 2, -(C=O)C 1-6 Alkyl, SF5;

[0196] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-41, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace;

[0197] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0198] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0199] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the aryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0200] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0201] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above.

[0202] Alternatively, a compound represented by formula (I6) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof is provided:

[0203] Where,

[0204] X is

[0205] Y1 is N or CH;

[0206] Y2 is N or CH;

[0207] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0208] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0209] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0210] R 00 is hydrogen or C 1-6 alkyl;

[0211] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0212] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0213] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0214] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0215] R 4a is substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl;

[0216] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C 1-4Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkenyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R03 R 04 );

[0217] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0218] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0219] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0220] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0221] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0222] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0223] Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07)(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ) or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0224] or Y3, R 12 Together with the nitrogen atom to which they are attached, they form a substituted or unsubstituted nitrogen-containing 3- to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0225] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0226] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0227] R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0228] R 08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0229] Y5 is O or S;

[0230] Y4 is O or S;

[0231] R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 14 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0232] R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0233] In each of the above groups, the substitution independently refers to the substitution of 1, 2, 3, 4, 5 or 6 hydrogen atoms on the above group by a group selected from Group S1; the groups in Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1- 6-alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C1-4 Alkyl-C(=O)-C 6- 14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NRa1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0234] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0235] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0236] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0237] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C1-6 Alkyl)2;

[0238] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl) 2, -(C=O)C 1-6 alkyl;

[0239] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace;

[0240] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0241] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C1-6 alkyl;

[0242] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the aryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0243] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0244] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above.

[0245] Alternatively, a compound represented by formula (I5) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof is provided:

[0246] Where,

[0247] X is

[0248] Y1 is N or CH;

[0249] Y2 is N or CH;

[0250] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0251] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0252] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0253] R 00 is hydrogen or C 1-6 alkyl;

[0254] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0255] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0256] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0257] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0258] R4 is C 1-6Alkyl or deuterated C 1-6 alkyl;

[0259] R 41 C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0260] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkenyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1- 4-Alkyl-NR01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );

[0261] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0262] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0263] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0264] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0265] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0266] R06 is hydrogen, deuterium or C 1-6 alkyl;

[0267] Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 07 ) or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0268] or Y3, R 12 Together with the nitrogen atom to which they are attached, they form a substituted or unsubstituted nitrogen-containing 3- to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0269] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0270] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0271] R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0272] Y5 is O or S;

[0273] Y4 is O or S;

[0274] R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 14is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0275] R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0276] In each of the above groups, the substitution independently refers to the substitution of 1, 2, 3, 4, 5 or 6 hydrogen atoms on the above group by a group selected from Group S1; the groups in Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1- 6-alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6- 14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 Rb1 ; wherein, the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0277] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0278] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0279] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0280] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0281] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl) 2, -(C=O)C 1-6 alkyl;

[0282] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace;

[0283] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0284] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0285] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the aryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0286] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0287] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above.

[0288] Alternatively, a compound represented by formula (I4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof is provided:

[0289] Where,

[0290] Y1 is N or CH;

[0291] Y2 is N or CH;

[0292] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0293] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0294] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0295] R 00 is hydrogen or C 1-6 alkyl;

[0296] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0297] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0298] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0299] R4 is C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0300] R 41 C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0301] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C2-4 Alkenyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );

[0302] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0303] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0304] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0305] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0306] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0307] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0308] Y3 is -C(=O)R6 or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0309] or Y3, R 12 Together with the nitrogen atom to which they are attached, they form a substituted or unsubstituted nitrogen-containing 3- to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, or sulfur;

[0310] R6 is substituted or unsubstituted C1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0311] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0312] Y5 is O or S;

[0313] Y4 is O or S;

[0314] R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 14 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0315] R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0316] In each of the above groups, the substitution independently refers to the substitution of 1, 2, 3, 4, 5 or 6 hydrogen atoms on the above group by a group selected from Group S1; the groups in Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1- 6-alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-ORc1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6- 14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、 -NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 ; wherein, the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0317] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0318] Each R a1 and R b1Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0319] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0320] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0321] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl) 2, -(C=O)C 1-6 alkyl;

[0322] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace;

[0323] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0324] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0325] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, or sulfur; 1-6 One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the aryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur;

[0326] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; Re Same definition as above.

[0327] Alternatively, a compound represented by formula (I3) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof is provided:

[0328] Where,

[0329] Y1 is N or CH;

[0330] Y2 is N or CH;

[0331] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0332] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0333] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0334] R 00 is hydrogen or C 1-6 alkyl;

[0335] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0336] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0337] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0338] R4 is C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0339] R 41 C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0340] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-CH=CR01 R 02 、-C 2-4 Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkenyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );

[0341] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0342] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0343] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0344] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0345] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C1-6 alkyl;

[0346] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0347] Y3 is -C(=O)R6 or R 11 ;

[0348] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0349] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0350] R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0351] R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 14 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0352] R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0353] In each of the above groups, the substitution independently refers to the substitution of 1, 2, 3, 4, 5 or 6 hydrogen atoms on the above group by a group selected from Group S1; the groups in Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1- 6-alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6- 14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 ; wherein, the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0354] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0355] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0356] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0357] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0358] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl) 2, -(C=O)C 1-6 alkyl;

[0359] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace;

[0360] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0361] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0362] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, or sulfur; 1-6One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur. or 5) ring atoms are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3 or 4) ring atoms of the 3 to 6 membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 5 to 15 membered tricyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 6 to 12 membered heteroaryl and heterocycloalkyl group are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 6 to 12 membered heteroaryl and heterocycloalkyl group are heteroatoms selected from nitrogen, oxygen or sulfur; wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally replaced by one or two heteroatoms selected from oxo and =NR e The group substituted; R e Same definition as above.

[0363] Alternatively, a compound represented by formula (I2) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof is provided:

[0364] Where,

[0365] Y1 is N or CH;

[0366] Y2 is N or CH;

[0367] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0368] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0369] L1 is -N(R 00)C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0370] R 00 is hydrogen or C 1-6 alkyl;

[0371] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0372] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0373] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0374] R4 is C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0375] R 41 C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0376] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02)、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );

[0377] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0378] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0379] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0380] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0381] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6alkyl;

[0382] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0383] Y3 is -C(=O)R6 or R 11 ;

[0384] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0385] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, or a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl;

[0386] R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0387] R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 14 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0388] R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0389] In each of the above groups, the substitution independently refers to the substitution of 1, 2, 3, 4, 5 or 6 hydrogen atoms on the above group by a group selected from Group S1; the groups in Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1- 6-alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6- 14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 ; wherein, the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0390] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0391] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0392] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0393] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0394] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl) 2, -(C=O)C 1-6 alkyl;

[0395] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace;

[0396] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0397] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0398] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, or sulfur; 1-6One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur. or 5) ring atoms are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3 or 4) ring atoms of the 3 to 6 membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 5 to 15 membered tricyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 6 to 12 membered heteroaryl and heterocycloalkyl group are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 6 to 12 membered heteroaryl and heterocycloalkyl group are heteroatoms selected from nitrogen, oxygen or sulfur; wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally replaced by one or two heteroatoms selected from oxo and =NR e (For example, when the ring atom is a sulfur atom, the sulfur atom can be substituted with S(=O), S(=O)2, S(=O)(=NR e ). ); R e Same definition as above.

[0399] Alternatively, a compound represented by formula (I1) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof is provided:

[0400] Where,

[0401] Y1 is N or CH;

[0402] Y2 is N or CH;

[0403] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0404] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0405] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0406] R 00 is hydrogen or C 1-6 alkyl;

[0407] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0408] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0409] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0410] R4 is C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0411] R 41 C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0412] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );

[0413] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0414] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0415] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0416] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0417] R 05 is hydrogen, deuterium, halogen or C 1-6 alkyl;

[0418] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0419] Y3 is -C(=O)R6 or R 11 ;

[0420] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0421] R11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, or a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl;

[0422] The substitutions are independently selected from the group consisting of deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 ; wherein, the C 1-6 Alkyl, the C 1-6Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0423] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0424] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0425] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0426] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0427] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 alkyl;

[0428] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f replace;

[0429] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0430] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0431] In the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, or sulfur; 1-6One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; One or more (e.g., 1, 2, 3, or 4) ring atoms of the 8- to 10-membered monocyclic heteroaryl are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen, or sulfur.

[0432] In one embodiment, R 4a for

[0433] In one embodiment, R 4a for

[0434] In one embodiment, R 4a C 1-6 Alkyl, preferably isopropyl.

[0435] In one embodiment, R 4b For deuterium, halogen, C 1-6 Alkyl or C 1-6 Heteroalkyl.

[0436] In one embodiment, R 4b For deuterium, halogen, C 1-6 Alkyl or C 1-6 Alkoxy.

[0437] In one embodiment, R 4b is chlorine, methyl or methoxy.

[0438] In one embodiment, the compound of the present invention (including but not limited to the compound of formula (I), the compound of formula (I1), the compound of formula (I2), the compound of formula (I3), the compound of formula (I4), the compound of formula (I5), the compound of formula (I6), the compound of formula (I7), the compound of formula (I8)) is as shown in formula (I-1) or formula (I-2):

[0439] Wherein, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 , Y1, Y2, Y3, and L1 are each as defined herein.

[0440] In one embodiment, the compound of the present invention (including but not limited to the compound of formula (I), the compound of formula (I1), the compound of formula (I2), the compound of formula (I3), the compound of formula (I4), the compound of formula (I5), the compound of formula (I6), the compound of formula (I7), the compound of formula (I8)) is as shown in formula (I-11) or formula (I-12):

[0441] Wherein, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 , Y1, Y2, R6, and L1 are each as defined herein.

[0442] In one embodiment, the compound of the present invention (including but not limited to the compound of formula (I), the compound of formula (I1), the compound of formula (I2), the compound of formula (I3), the compound of formula (I4), the compound of formula (I5), the compound of formula (I6), the compound of formula (I7), the compound of formula (I8)) is as shown in formula (I-111), formula (I-121), formula (I'-111) or formula (I'-121):

[0443] Where, R3, R4, R5, R 41 、R 42 、R 43 Each is as defined herein.

[0444] In one embodiment, the compound of the present invention (including but not limited to the compound of formula (I), the compound of formula (I1), the compound of formula (I2), the compound of formula (I3), the compound of formula (I4), the compound of formula (I5), the compound of formula (I6), the compound of formula (I7), the compound of formula (I8)) is as shown in formula (I-112), formula (I-122), formula (I'-112) or formula (I'-122):

[0445] Where, R3, R4, R5, R41 、R 42 、R 43 、R 46 Each is as defined herein.

[0446] In one embodiment, the compound of the present invention (including but not limited to the compound of formula (I), the compound of formula (I1), the compound of formula (I2), the compound of formula (I3), the compound of formula (I4), the compound of formula (I5), the compound of formula (I6), the compound of formula (I7), the compound of formula (I8)) is as shown in formula (I-21) or formula (I-22):

[0447] Wherein, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 、Y1、Y2、R 11 , L1 are each as defined herein.

[0448] In one embodiment, the above compound is represented by formula (I-3) or formula (I-4):

[0449] Where, Y1, Y2, R1, R2, R3, R 4a , R5, R 42 、R 43 , L1 are defined as before.

[0450] In one embodiment, Y1 is N; wherein N can be oxidized (N + -O - ).

[0451] In one embodiment, Y2 is CR 4b ; R 4b For deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 Heteroalkyl.

[0452] In one embodiment, the compound of formula (I-3) is as shown in formula (I-31) or (I-32):

[0453] Where, R1, R2, R3, R 4a , R5, R 42 、R 43 , L1 are defined as before.

[0454] In one embodiment, R 4b Halogen, C1-6 Alkyl or C 1-6 Alkoxy.

[0455] In one embodiment, R 4b is chlorine, methyl or methoxy.

[0456] In one embodiment, R 4a C 1-6 Alkyl, preferably isopropyl.

[0457] In one embodiment, R3 is ethyl.

[0458] In one embodiment, L1 is thiazolyl.

[0459] In one embodiment, R 43 、R 42 It is a methyl group.

[0460] In one embodiment, R1 and R2 are hydrogen.

[0461] In one embodiment, R5 is -NR 01 R 02 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, or sulfur; the substitutions independently refer to 1, 2, 3, 4, 5, or 6 hydrogen atoms on the above group being replaced by a group selected from Group S1; the group S1 is selected from ═CR e R f ; R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0462] In one embodiment, R5 is -OC 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02Together with the connected nitrogen atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; one or more (such as 1, 2, 3 or 4) ring atoms of the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; the substitutions independently refer to 1, 2, 3, 4, 5 or 6 hydrogen atoms on the above group being replaced by a group selected from Group S1; wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0463] In one embodiment, R5 is -C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 ; R 01 、R 02 Together with the connected nitrogen atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; one or more (such as 1, 2, 3 or 4) ring atoms of the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; the substitutions independently refer to 1, 2, 3, 4, 5 or 6 hydrogen atoms on the above group being replaced by a group selected from Group S1; wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1- 6-alkyl or deuterated C 1-6 alkyl.

[0464] In one embodiment, the 7- to 12-membered bicyclic heterocyclyl is selected from the group consisting of:

[0465] In one embodiment, the 3- to 8-membered monocyclic heterocyclyl is selected from the group consisting of:

[0466] In one embodiment, the 3- to 8-membered monocyclic heterocyclyl is selected from the group consisting of:

[0467] In one embodiment, the 3 to 8 membered monocyclic heterocyclic group is optionally selected from cyano, hydroxy, 5 or 6 membered monocyclic heteroaryl, -NR a1 R b1 or -N=S(=O)(R g1 )(R h1) is substituted by a substituent.

[0468] In one embodiment, the 5- or 6-membered monocyclic heteroaryl group is pyridine, wherein the nitrogen atom in the pyridine group may be optionally oxidized (N + -O - ).

[0469] In one embodiment, R a1 、R b1 Each independently is H or phenyl; the phenyl group is optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2.

[0470] In one embodiment, R a1 、R b1 Each is independently H or phenyl; said phenyl is optionally substituted with -P(=O)-(CH3)2.

[0471] In one embodiment, R g1 、R h1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl, preferably C 1-6 alkyl.

[0472] In one embodiment, R5 is

[0473] The first aspect of the present invention further provides a compound represented by formula (A) or formula (A') or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0474] Where,

[0475] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl; and R 42 and R 43 are not methyl at the same time; or

[0476] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0477] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0478] R 00 is hydrogen or C 1-6 alkyl;

[0479] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0480] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0481] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0482] R4 is C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0483] R 41 C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0484] R5 is -NR 01 R 02 or -C(R 05 )R03 R 04 ;

[0485] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group; the 5- to 15-membered tricyclic heterocyclic group has, in addition to the existing nitrogen atom, 0 or more (e.g., 0, 1, 2, 3, 4 or 5) ring atoms selected from nitrogen, oxygen or sulfur heteroatoms;

[0486] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 9- to 11-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen, or sulfur;

[0487] R 05 is hydrogen, deuterium or C 1-6 alkyl;

[0488] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0489] The substitutions are independently selected from the group consisting of deuterium, oxo (=O), thio (=S), CR e R f , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1- 6-alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NRa1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 ; wherein, the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0490] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1- 6-alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1- 4-alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0491] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6Alkyl)2;

[0492] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0493] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0494] In the above groups, the groups of each S2 group are independently selected from the following groups: oxo (C=O), thio (=S), =CR e R f , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 alkyl;

[0495] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl groups or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6;

[0496] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0497] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0498] In the above groups, one or more (such as 1, 2, 3 or 4) ring atoms of the 3- to 8-membered heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; 1-6 One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 9- to 11-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; 5) ring atoms are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3 or 4) ring atoms of the 5- or 6-membered monocyclic heteroaryl are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3 or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen or sulfur.

[0499] In one embodiment, the compound is represented by formula (A-1), formula (A-2), formula (A'-1) or formula (A'-2):

[0500] wherein R1, R2, R3, R4, R5, R6, and L1 are each as defined herein.

[0501] In one embodiment, the compound is represented by formula (A-3) or formula (A'-3):

[0502] wherein R1, R2, R3, R4, R5, R6, and L1 are each as defined herein.

[0503] In one embodiment, the compound is represented by formula (A-4) or formula (A'-4):

[0504] wherein R1, R2, R3, R4, R5, R6, and L1 are each as defined herein.

[0505] In one embodiment, R6 is substituted or unsubstituted C 3-6 cycloalkyl; the substitution is as defined herein.

[0506] In one embodiment, R6 is C 1-6 Preferably, R6 is a cyclopropyl group substituted by methyl. Preferably, R6 is a cyclopropyl group substituted by two methyl groups. For example, R6 is

[0507] In one embodiment, R4 is methyl or deuterated methyl (eg, CD3).

[0508] In one embodiment, R 41 is a methyl group or a deuterated methyl group (eg, CD3).

[0509] In one embodiment, R5 is

[0510] R 011 、R 012 are independently hydrogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R 011 、R 012 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 Cycloalkyl; the substitution is as defined herein;

[0511] X1 is a bond, S, O or N(R 013 );R 013 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0512] R 05 is hydrogen, deuterium or C 1-6 alkyl.

[0513] In one embodiment, R5 is

[0514] In one embodiment, R5 is

[0515] In one embodiment, R5 is Preferably, R5 is

[0516] In one embodiment, R3 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0517] In one embodiment, R3 is methyl, ethyl or propyl (including isopropyl or n-propyl).

[0518] In one embodiment, R3 is hydrogen, C 1-6 Alkyl or halogenated C 1-6 alkyl.

[0519] In one embodiment, R3 is trifluoromethyl, trifluoroethyl or trifluoropropyl.

[0520] In one embodiment, R1 is hydrogen, C 1-6 Alkoxy or deuterated C 1-6 Alkoxy; R2 is hydrogen.

[0521] In one embodiment, R1 is hydrogen, methoxy, ethoxy, propoxy, or butoxy; and R2 is hydrogen.

[0522] In one embodiment, R1 is hydrogen; R2 is hydrogen.

[0523] In one embodiment, R1 is ethoxy; and R2 is hydrogen.

[0524] In one embodiment, L1 is a 5- or 6-membered monocyclic heteroaryl.

[0525] In one embodiment, L1 is thiazolyl.

[0526] In one embodiment, R 42 is methyl, R 43 It is trifluoromethyl.

[0527] In one embodiment, R 42 is hydrogen, R 43 It is trifluoromethyl.

[0528] In one embodiment, R 42 is fluorine, R 43 It is trifluoromethyl.

[0529] In one embodiment, R 42 is hydrogen, R 43 For fluorine.

[0530] In one embodiment, R 42 is hydrogen, R 43 It is a methyl group.

[0531] In one embodiment, R 42 and R 43 Together with the carbon atom to which it is attached, it forms a cyclopropyl or cyclobutyl group.

[0532] In one embodiment, R 42 and R 43 Not methyl at the same time.

[0533] In one embodiment, R 42 is hydrogen; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl.

[0534] In one embodiment, R 42 and R 43 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted cyclopropyl group, a substituted or unsubstituted cyclobutyl group, or a substituted or unsubstituted cyclopentyl group.

[0535] In one embodiment, R 42 and R 43 Together with the attached carbon atom, it forms an unsubstituted cyclopropyl group.

[0536] In one embodiment, R6 is halogen-substituted or unsubstituted C 1-6 alkyl.

[0537] In one embodiment, R 42 、R 43 At the same time it is methyl.

[0538] In one embodiment, R5 is hydrogen or methylpiperazinyl.

[0539] In one embodiment, R 14 For hydrogen.

[0540] In one embodiment, R 13 For hydrogen.

[0541] In one embodiment, R 12 For hydrogen.

[0542] In one embodiment, R 42 and R 43 All are methyl.

[0543] In one embodiment, R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 Cycloalkyl.

[0544] In one embodiment, R6 is a halogen-substituted C 1-6 Alkyl, preferably F-substituted C 1-6 alkyl.

[0545] In one embodiment, R6 is substituted or unsubstituted cyclopropyl.

[0546] In one embodiment, R6 is C 1-6 The cyclopropyl group substituted by an alkyl group is preferably a cyclopropyl group substituted by one or two methyl groups.

[0547] In one embodiment, R6 is

[0548] In one embodiment, R6 is

[0549] In one embodiment, R6 is

[0550] In one embodiment, R6 is

[0551] The first aspect of the present invention further provides a compound represented by formula (C) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0552] Wherein, Y1, Y2, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 , L1 are each as defined herein.

[0553] In one embodiment, R5 is -NR 01 R 02 、-CR 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06)C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 Alkyl-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl;

[0554] R 01 、R 02 Each independently selected from C 1-6 Alkyl; or

[0555] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 8-membered monocyclic heterocyclic group;

[0556] The C 1-6The alkyl group or the 5- to 8-membered monocyclic heterocyclic group is optionally substituted with a substituent selected from the aforementioned S1 group;

[0557] Furthermore, the C 1-6 The alkyl group is optionally replaced by -C 1-4 Alkyl-3 to 20-membered heterocyclic group or -C(=O)-3 to 20-membered heterocyclic group, wherein the 3 to 20-membered heterocyclic group is optionally substituted by a substituent selected from the aforementioned S2 group.

[0558] R 03 、R 04 are each independently selected from substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group wherein j is 2, 3, 4, 5 or 6.

[0559] The C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 The alkynyl group is optionally substituted with a substituent selected from the aforementioned S1 group.

[0560] In one embodiment, R5 is

[0561] In one embodiment, R5 is

[0562] In one embodiment, R5 is selected from the group consisting of:

[0563] In one embodiment, R3 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0564] In one embodiment, R3 is methyl, ethyl or propyl (including isopropyl or n-propyl).

[0565] In one embodiment, R1 is hydrogen, C 1-6 Alkoxy or deuterated C 1-6 Alkoxy; R2 is hydrogen.

[0566] In one embodiment, R1 is hydrogen, methoxy, ethoxy, propoxy, or butoxy; and R2 is hydrogen.

[0567] In one embodiment, L1 is a 5- or 6-membered monocyclic heteroaryl.

[0568] In one embodiment, L1 is thiazolyl.

[0569] The first aspect of the present invention further provides a compound represented by formula (B) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0570] Where,

[0571] A is N, C(H) or C(D);

[0572] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0573] R 00 is hydrogen or C 1-6 alkyl;

[0574] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0575] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0576] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0577] R7 is C1-6 Alkyl or deuterated C 1-6 alkyl;

[0578] R 71 C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0579] R8 is C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0580] And when R8 does not 10 When forming a ring, R7, R 71 and R8 is deuterated C 1-6 alkyl;

[0581] R9 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0582] R 10 is hydrogen, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0583] The above substitutions are each independently substituted by 1, 2, 3 or 4 hydrogen atoms on the above groups with groups selected from S1 group; the groups of S1 group are each independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1- 6-alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1-S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 ; wherein, the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0584] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1- 4-alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1- 6-alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1- 4-alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0585] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1- 6 alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0586] In the above groups, each R d1Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0587] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0588] Or R8 and R 10 Together with the atoms to which it is attached, it forms a 3- to 20-membered heterocyclic group which is unsubstituted or substituted by 1, 2, 3 or 4 groups selected from Group S2, a 5- or 6-membered monocyclic heteroaryl group which is unsubstituted or substituted by 1, 2, 3 or 4 groups selected from Group S2, or an 8- to 10-membered bicyclic heteroaryl group which is unsubstituted or substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0589] In the above groups, the groups of each S2 group are independently selected from the following groups: oxo (C=O), thio (=S), =CR e R f , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 alkyl;

[0590] In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl groups or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6;

[0591] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0592] In the above groups, Rf are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0593] In the above groups, one or more (such as 1, 2, 3 or 4) ring atoms of the 3- to 8-membered heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; 1-6 One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur.

[0594] In one embodiment, the compound is represented by formula (B-1) or formula (B-2):

[0595] wherein R1, R2, R3, R7, R8, R9, and L1 are each as defined herein.

[0596] In one embodiment, the compound is represented by formula (B-3):

[0597] wherein R1, R2, R3, R7, R8, R9, and L1 are each as defined herein.

[0598] In one embodiment, the compound is represented by formula (B-4):

[0599] wherein R1, R2, R3, R7, R8, R9, and L1 are each as defined herein.

[0600] In one embodiment, R 71 It is methyl or deuterated methyl.

[0601] In one embodiment, R7 is methyl or deuterated methyl.

[0602] In one embodiment, R8 is methyl or deuterated methyl.

[0603] In one embodiment, R8 and R 10 Together with the atoms to which it is connected, it forms a 5-membered heterocyclic group which is unsubstituted or substituted by 1, 2, 3 or 4 groups selected from Group S2, a 6-membered heterocyclic group which is unsubstituted or substituted by 1, 2, 3 or 4 groups selected from Group S2, or a 5- or 6-membered monocyclic heteroaryl which is unsubstituted or substituted by 1, 2, 3 or 4 groups selected from Group S2.

[0604] In one embodiment, R9 is a halo-C 1-6 Preferably, R9 is fluoromethyl, fluoroethyl, fluoropropyl or fluorobutyl.

[0605] In one embodiment, R9 is substituted or unsubstituted C 3-6 Cycloalkyl.

[0606] In one embodiment, R9 is substituted or unsubstituted cyclopropyl. In one embodiment, R9 is C 1-6 The cyclopropyl group substituted by an alkyl group is preferably a cyclopropyl group substituted by one or two methyl groups.

[0607] In one embodiment, R9 is

[0608] In one embodiment, R3 is hydrogen or C 1-6 alkyl.

[0609] In one embodiment, R3 is methyl, ethyl or propyl (including isopropyl or n-propyl).

[0610] In one embodiment, R1 is hydrogen or C 1-6 Alkoxy; R2 is hydrogen.

[0611] In one embodiment, R1 is hydrogen, methoxy, ethoxy, propoxy, or butoxy; and R2 is hydrogen.

[0612] In one embodiment, L1 is a 5- or 6-membered monocyclic heteroaryl.

[0613] In one embodiment, L1 is thiazolyl.

[0614] In one embodiment, the S2 group of substituents is selected from the group consisting of halogen, oxo, methyl, ethyl, halomethyl, haloethyl, deuterated methyl, deuterated ethyl, ═CR e R f .

[0615] In one embodiment, R e are each independently H, fluoro, methyl, ethyl, halomethyl, haloethyl, deuterated methyl or deuterated ethyl; Rf Each is independently H, fluorine, methyl, ethyl, halomethyl, haloethyl, deuterated methyl or deuterated ethyl.

[0616] In one embodiment, the compound is selected from the group consisting of Z63 and Z66.

[0617] In one embodiment, the compound is selected from the group consisting of Z64, Z65, Z67, and Z68.

[0618] The first aspect of the present invention further provides a compound represented by formula (D) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0619] Wherein, Y1, Y2, R1, R2, R3, R4, R5, R 11 、R 41 、R 42 、R 43 , L1, are each as defined herein.

[0620] In one embodiment, the compound is represented by Formula (D-1), Formula (D-2), Formula (D-3), Formula (D-4), Formula (D'-1), Formula (D'-2), Formula (D'-3) or Formula (D'-4):

[0621] Wherein, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 、R 11 , L1, are each as defined herein.

[0622] In one embodiment, the compound is represented by formula (D-11), formula (D-21), formula (D-31), formula (D-41), formula (D'-11), formula (D'-21), formula (D'-31) or formula (D'-41):

[0623] Wherein, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 、R 11 , L1, are each as defined herein.

[0624] In one embodiment, R 11 for

[0625] Where X2 is NH, O or CR 013 ; X3, X4 are each independently N or CR 013 ;

[0626] R 013 、R 014 are independently hydrogen, halogen, oxo, C 1-6 Alkyl or C 1-6 Alkoxy; m is 1, 2, or 3;

[0627] R 015 、R 016 are independently hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl or -C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl; or R 015 、R 016 Together with the attached carbon atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl; the substitution is as defined herein.

[0628] In one embodiment, R 11 is pyrrolidinyl, isoxazolyl, triazolyl, pyridazinyl or triazolopyridinyl, wherein the pyrrolidinyl, isoxazolyl, triazolyl, pyridazinyl or triazolopyridinyl is optionally selected from oxo, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, -C 1-4 The substituents of the alkyl-5- or 6-membered heteroaryl group are substituted.

[0629] In one embodiment, R 11 for

[0630] In one embodiment, R 11 for

[0631] In one embodiment, R 11 for

[0632] In one embodiment, R 11 for

[0633] In one embodiment, R 11 for

[0634] In one embodiment, R 11 for

[0635] In one embodiment, R 11 for

[0636] In one embodiment, R 11 for,

[0637] In one embodiment, R3 is hydrogen or C 1-6 alkyl.

[0638] In one embodiment, R3 is hydrogen, halo 1-6 Alkyl or C 1-6 alkyl.

[0639] In one embodiment, R3 is methyl, ethyl or propyl (including isopropyl or n-propyl).

[0640] In one embodiment, R3 is ethyl.

[0641] In one embodiment, R3 is haloethyl. In one embodiment, R3 is trifluoroethyl.

[0642] In one embodiment, R1 is hydrogen or C 1-6 Alkoxy; R2 is hydrogen.

[0643] In one embodiment, R1 is hydrogen, methoxy, ethoxy, propoxy, or butoxy; and R2 is hydrogen.

[0644] In one embodiment, R1 is hydrogen; R2 is hydrogen.

[0645] In one embodiment, L1 is a 5- or 6-membered monocyclic heteroaryl.

[0646] In one embodiment, L1 is thiazolyl.

[0647] The first aspect of the present invention further provides a compound represented by formula (E) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0648] Wherein, R1, R2, R3, R4, R5, R6, R 41 、R 42 、R 43 , Y1, Y2, L1, are each as defined herein.

[0649] In one embodiment, the compound of formula (E) is represented by formula (E1) or (E2):

[0650] Wherein, R1, R2, R3, R4, R5, R6, R 41 , L1, are each as defined herein.

[0651] In one embodiment, R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 Cycloalkyl.

[0652] In one embodiment, R6 is a halogen-substituted C 1-6 Alkyl, preferably F-substituted C 1-6 alkyl.

[0653] In one embodiment, R6 is C 1-6 The cyclopropyl group substituted by an alkyl group is preferably a cyclopropyl group substituted by one or two methyl groups.

[0654] In one embodiment, R6 is

[0655] In one embodiment, R5 is -NR 01 R 02 、-CR 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 Alkyl-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl;

[0656] R 01 、R 02 Each independently selected from C 1-6Alkyl; or

[0657] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 8-membered monocyclic heterocyclic group;

[0658] The C 1-6 The alkyl group or the 5- to 8-membered monocyclic heterocyclic group is optionally substituted with a substituent selected from the aforementioned S1 group;

[0659] Furthermore, the C 1-6 The alkyl group is optionally replaced by -C 1-4 Alkyl-3 to 20-membered heterocyclic group or -C(=O)-3 to 20-membered heterocyclic group, wherein the 3 to 20-membered heterocyclic group is optionally substituted by a substituent selected from the aforementioned S2 group;

[0660] R 03 、R 04 are each independently selected from substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6;

[0661] The C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 The alkynyl group is optionally substituted with a substituent selected from the aforementioned S1 group.

[0662] In one embodiment, R5 is -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1- 4-alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-5 to 15-membered tricyclic heterocyclic group, -OC 1-4Alkyl-7 to 12 membered bicyclic heterocyclyl, -O-3 to 8 membered monocyclic heterocyclyl, -O-5 to 15 membered tricyclic heterocyclyl, -O-7 to 12 membered bicyclic heterocyclyl; wherein each group is as defined herein.

[0663] In one embodiment, R5 is

[0664] In one embodiment, R5 is

[0665] In one embodiment, R5 is selected from the group consisting of:

[0666] In one embodiment, R3 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0667] In one embodiment, R3 is methyl, ethyl or propyl (including isopropyl or n-propyl).

[0668] In one embodiment, R1 is hydrogen, C 1-6 Alkoxy or deuterated C 1-6 Alkoxy; R2 is hydrogen.

[0669] In one embodiment, R1 is hydrogen, methoxy, ethoxy, propoxy, or butoxy; and R2 is hydrogen.

[0670] In one embodiment, L1 is a 5- or 6-membered monocyclic heteroaryl.

[0671] In one embodiment, L1 is thiazolyl.

[0672] In one embodiment, Y1 is N; and Y2 is CH.

[0673] In one embodiment, Y1 is CH; Y2 is N.

[0674] In one embodiment, Y1 is N; Y2 is N.

[0675] In one embodiment, Y1 is Y2 is CH.

[0676] In one embodiment, Y1 is CH; Y2 is

[0677] The first aspect of the present invention further provides a compound represented by formula (F) or formula (G) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0678] Wherein, R1, R2, R3, R4, R6, R 41 、R 42 、R 43 、R 11 , Y1, Y2, L1, respectively defined as before;

[0679] R 15 Selected from-NR 01 R 02 、-C(=O)-NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 or -C 1-4 Alkyl-C(R 05 )R 03 R 04 ;

[0680] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 alkyl)3-Si-; or,

[0681] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or

[0682] R 01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0683] R 03 、R 04are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0684] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0685] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0686] The substitutions independently refer to 1, 2, 3 or 4 hydrogen atoms on the above groups being replaced by groups selected from Group S1; the groups in Group S1 are as defined above.

[0687] The first aspect of the present invention further provides a compound represented by formula (F1) or formula (G1) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

[0688] Wherein, R1, R2, R3, R4, R6, R 41 、R 42 、R 43 、R 11 , Y1, Y2, L1, respectively defined as before;

[0689] R 15 Selected from-NR 01 R 02 、-C(=O)-NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 or -C 1-4 Alkyl-C(R 05)R 03 R 04 ;

[0690] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 alkyl)3-Si-; or,

[0691] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or

[0692] R 01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0693] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0694] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0695] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6alkyl;

[0696] The substitutions independently refer to 1, 2, 3 or 4 hydrogen atoms on the above groups being replaced by groups selected from Group S1; the groups in Group S1 are as defined above.

[0697] In one embodiment, the compound is a compound prepared in any of the Examples.

[0698] The aforementioned compounds of the present invention do not include specific compound structures disclosed in the prior art for inhibiting RAS activity.

[0699] The second aspect of the present invention provides a pharmaceutical composition comprising the compound described in the first aspect above or its stable deuterated derivative or stereoisomer, or its pharmaceutically acceptable salt, solvate or prodrug; and a pharmaceutically acceptable carrier.

[0700] The third aspect of the present invention provides the aforementioned compound as a medicament.

[0701] As used herein, the term "pharmaceutically acceptable carrier" refers to any formulation or carrier medium capable of delivering an effective amount of the active substance of the present invention, without interfering with the biological activity of the active substance and without toxic side effects on the host or subject. Representative carriers include water, oils, vegetables and minerals, cream bases, lotion bases, ointment bases, etc. These bases include suspending agents, viscosity increasing agents, transdermal enhancers, etc. Their preparation is well known to those skilled in the field of cosmetics or topical medicine.

[0702] In an embodiment of the present invention, the pharmaceutical composition can be administered in any of the following ways: orally, by spray inhalation, rectally, nasally, buccally, topically, parenterally, such as by subcutaneous, intravenous, intramuscular, intraperitoneal, intrathecal, intraventricular, intrasternal, and intracranial injection or infusion, or by means of an explanted reservoir. Among these, oral, intraperitoneal, or intravenous administration is preferred. When administered orally, the compounds of the present invention can be prepared into any orally acceptable dosage form, including but not limited to tablets, capsules, aqueous solutions, or aqueous suspensions. Carriers used in tablets generally include lactose and corn starch, and lubricants such as magnesium stearate may also be added. Diluents used in capsule formulations generally include lactose and dried corn starch. Aqueous suspension formulations are typically prepared by mixing the active ingredient with a suitable emulsifier and suspending agent. If desired, sweeteners, flavorings, or coloring agents may also be added to the above oral formulations. For topical administration, particularly for the treatment of affected areas or organs readily accessible by topical application, such as the eyes, skin, or lower intestinal neurological disorders, the compounds of the present invention can be formulated into different topical formulations depending on the affected area or organ. For topical ophthalmic administration, the compounds of the present invention can be formulated into a micronized suspension or solution in an isotonic, sterile saline solution at a specific pH, with or without a preservative such as benzyl chloride. For ophthalmic administration, the compounds can also be formulated into an ointment such as vaseline. For topical skin administration, the compounds of the present invention can be formulated into a suitable ointment, lotion, or cream formulation, wherein the active ingredient is suspended or dissolved in one or more carriers. Carriers that can be used for ointment preparations include, but are not limited to, mineral oil, liquid petrolatum, white petrolatum, propylene glycol, polyethylene oxide, polypropylene oxide, emulsifying wax, and water; carriers that can be used for lotions or creams include, but are not limited to, mineral oil, sorbitan monostearate, Tween 60, cetyl esters wax, hexadecene aryl alcohol, 2-octyldodecanol, benzyl alcohol, and water. The compounds of the present invention can also be administered in the form of sterile injectable preparations, including sterile water for injection or oil suspensions or sterile injectable solutions. Useful carriers and solvents include water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils such as monoglycerides or diglycerides can also be used as solvents or suspending media.

[0703] Another aspect of the present invention provides the use of the compound described in the first aspect above, or its stable deuterated derivative or stereoisomer, or its pharmaceutically acceptable salt, solvate or prodrug, or the pharmaceutical composition described in the second aspect above, in the preparation of a medicament for preventing and / or treating a disease or condition; the disease or condition is a disease or condition related to RAS protein activity.

[0704] Another aspect of the present invention provides a method for preventing and / or treating diseases or conditions related to RAS protein activity, comprising the steps of: administering to a subject in need thereof a therapeutically effective amount of the compound of the first aspect of the invention or its stable deuterated derivative or stereoisomer, or a pharmaceutically acceptable salt, solvate or prodrug thereof; or administering to a subject in need thereof a therapeutically effective amount of the pharmaceutical composition of the second aspect of the invention.

[0705] Herein, in one embodiment, the disease or disorder associated with RAS protein activity is cancer, including but not limited to pancreatic cancer, colorectal cancer, non-small cell lung cancer, acute myeloid leukemia, multiple myeloma, thyroid adenocarcinoma, myelodysplastic syndrome, squamous cell lung cancer, esophageal cancer, ovarian cancer, uterine cancer, melanoma, bladder cancer or head and neck cancer.

[0706] In one embodiment, the cancer comprises wild-type RAS and RAS mutations. The RAS includes HRAS, KRAS, and NRAS.

[0707] In one embodiment, the RAS mutation is KRAS G12C, KRAS G12D, KRAS G12V, KRAS G12S, KRAS G13C, KRAS G13D, KRAS Q61L, KRAS Q61H, NRAS G12C, NRAS Q61K, NRAS Q61R, or other RAS mutations.

[0708] Herein, the use or method further comprises administering an additional anti-cancer therapy. In some embodiments, the additional anti-cancer therapy is a HER2 inhibitor, an EGFR inhibitor, a second RAS inhibitor, a SHP2 inhibitor, an SOS1 inhibitor, a RAF inhibitor, a MEK inhibitor, an ERK inhibitor, a PI3K inhibitor, a PTEN inhibitor, an AKT inhibitor, an mTORC1 inhibitor, a BRAF inhibitor, a PD-L1 inhibitor, a PD-1 inhibitor, a CDK4 / 6 inhibitor, or a combination thereof.

[0709] Another aspect of the present invention provides a method for treating cancer in a subject in need thereof, the method comprising:

[0710] (a) determining that the cancer is associated with RAS protein activity; and

[0711] (b) administering to the subject a therapeutically effective amount of the compound of the first aspect of the invention or its stable deuterated derivative or stereoisomer, or a pharmaceutically acceptable salt, solvate or prodrug thereof; or administering to the subject a therapeutically effective amount of the pharmaceutical composition of the second aspect of the invention.

[0712] In one embodiment, the administration is accomplished by a route selected from the group consisting of parenteral, intraperitoneal, intradermal, intracardiac, intraventricular, intracranial, intracerebrospinal, intracavitary, intrasynovial, intrathecal, intramuscular, intravitreal, intravenous, intraarterial, oral, buccal, sublingual, transdermal, topical, intratracheal, rectal, subcutaneous, and local administration.

[0713] Another aspect of the present invention provides a method for inhibiting RAS protein activity in a cell, comprising the steps of: contacting the cell with the compound of the first aspect of the present invention, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof; or contacting the cell with the pharmaceutical composition of the second aspect of the present invention. The cell may be in vivo or in vitro.

[0714] Another aspect of the present invention provides the use of the compound described in the first aspect above, or its stable deuterated derivative or stereoisomer, or its pharmaceutically acceptable salt, solvate or prodrug, or the pharmaceutical composition described in the second aspect above, in the preparation of a RAS protein activity inhibitor.

[0715] Another aspect of the present invention provides a method for preparing the compound of the first aspect, comprising:

[0716] In the formula, B2 is an amino protecting group well known in the art, such as an alkoxycarbonyl group, such as tert-butyloxycarbonyl (Boc); a formyl group; an acyl group, such as an alkanoyl group (such as acetyl, trichloroacetyl or trifluoroacetyl); an arylmethoxycarbonyl group, such as benzyloxycarbonyl (Cbz) and 9-fluorenylmethoxycarbonyl (Fmoc); an arylmethyl group, such as benzyl (Bn), trityl (Tr), 1,1-bis-(4'-methoxyphenyl)methyl; a silyl group, such as trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS), etc. R1, R2, R 42 、R 43 、R 12 、R 13 、R 14 , L1, Y3, Y4, Y5, and ring A are defined as before.

[0717] The compound of formula (a) of the present invention can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible or similar to those described in the following examples, or reaction conditions known in the art (e.g., the method or conditions described in WO2022060836A1) are used;

[0718] In the formula, B2 is an amino protecting group well known in the art, such as an alkoxycarbonyl group, such as tert-butyloxycarbonyl (Boc); a formyl group; an acyl group, such as an alkanoyl group (such as acetyl, trichloroacetyl or trifluoroacetyl); an arylmethoxycarbonyl group, such as benzyloxycarbonyl (Cbz) and 9-fluorenylmethoxycarbonyl (Fmoc); an arylmethyl group, such as benzyl (Bn), trityl (Tr), 1,1-bis-(4'-methoxyphenyl)methyl; a silyl group, such as trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS), etc. Q2 and Q3 are each independently selected from a halogen atom, a boronic acid group or a boronic ester group; provided that: when Q2 is selected from a halogen atom, Q3 is selected from a boronic acid group or a boronic ester group, and when Q3 is selected from a halogen atom, Q2 is selected from a boronic acid group or a boronic ester group; the boronic acid group or boronic ester group is selected from Or -B(OH)2. R1, R2, R 42 、R 43 、R 12 、R 13 、R 14 , L1, Y3, Y4, and Y5 are defined as before. for for

[0719] The compound of formula (i) of the present invention can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible with or similar to those described in the following examples, or reaction conditions known in the art are used;

[0720] Wherein, B1 is a hydroxy protecting group well known in the art, for example, ethers, such as methyl, tert-butyl, benzyl, methoxybenzyl, trityl, silane ethers (trimethylsilane (TMS), tert-butyldimethyl (TBDMS), tert-butyldiphenyl (TBDPS), triethylsilane (TES), triisopropylsilane (TIPS)); sulfonyl chloride, such as trifluoromethanesulfonyl (Tf); acetals, such as MOM, THP, etc. B2 is an amino protecting group well known in the art, such as an alkoxycarbonyl group, such as tert-butyloxycarbonyl (Boc); a formyl group; an acyl group, such as an alkanoyl group (such as acetyl, trichloroacetyl or trifluoroacetyl); an arylmethoxycarbonyl group, such as benzyloxycarbonyl (Cbz) and 9-fluorenylmethoxycarbonyl (Fmoc); an arylmethyl group, such as benzyl (Bn), trityl (Tr), 1,1-bis-(4'-methoxyphenyl)methyl; a silyl group, such as trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS), etc. Q1 and Q2 are each independently selected from a halogen atom, a boronic acid group or a boronic ester group; provided that: when Q2 is selected from a halogen atom, Q1 is selected from a boronic acid group or a boronic ester group, and when Q1 is selected from a halogen atom, Q2 is selected from a boronic acid group or a boronic ester group; the boronic acid group or the boronic ester group is selected from Or -B(OH)2. R1, R2, R 42 、R 43 、R 12 、R 13 、R 14 , L1, Y3, Y4, Y5, and ring A are defined as before. for

[0721] Another aspect of the present invention provides the following intermediate compound and a preparation method thereof, which comprises:

[0722] The compound of formula (ii) can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible with or similar to those described in Preparation Example 3, or reaction conditions known in the art are used;

[0723] The compound of formula (iii) can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible with or similar to those described in Preparation Example 4, or reaction conditions known in the art are used;

[0724] The compound of formula (iv) can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible with or similar to those described in Preparation Example 5, or reaction conditions known in the art are used;

[0725] The compound of formula (v) or formula (vA) can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible or similar to those described in Preparation 6 or Preparation Example 7, or reaction conditions known in the art are used;

[0726] Synthesis Route 1:

[0727] Synthesis route 2:

[0728] The compound of formula (vi) can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible or similar to those described in Preparation 8 or Preparation Example 9, or reaction conditions known in the art are used;

[0729] Synthesis route 3:

[0730] Synthesis route

[0731] The compound of formula (vii) can be synthesized by the following method, wherein the solvent, temperature and other reaction conditions in each step are compatible or similar to those described in Preparation 10, or reaction conditions known in the art are used;

[0732] In the above formula, Q1 and Q2 are each independently selected from the aforementioned halogen atom, boronic acid group or borate ester group; B2 and B3 are selected from the aforementioned amino protecting group; B1 and B4 are selected from the aforementioned hydroxyl protecting group.

[0733] As used herein, the term "subject" refers to an animal, particularly a mammal, preferably a human.

[0734] As used herein, the term "effective amount" or "therapeutically effective amount" refers to a non-toxic but sufficient amount of a drug or medicament that achieves the desired effect. In embodiments of the present invention, when treating a patient according to the present invention, the amount of a given drug depends on many factors, such as specific dosing regimen, disease or condition type and severity thereof, the uniqueness (e.g., body weight) of the patient or host in need of treatment, but, according to specific surrounding circumstances, including, for example, the specific drug, route of administration, condition for treatment, and the patient or host for treatment, the dosage can be conventionally determined by methods known in the art. Typically, for adult treatment, the dosage is typically in the range of 0.02-5000 mg / day, such as about 1-1500 mg / day. The desired dose can be conveniently expressed as a single dose, or simultaneously administered (or in a short period of time) or in divided doses at appropriate intervals, such as two, three, four, or more divided doses per day. It will be appreciated by those skilled in the art that, although the above-mentioned dosage range has been provided, the specific effective amount can be appropriately adjusted according to the patient's situation and in conjunction with the physician's diagnosis.

[0735] As used herein, the term "pharmaceutically acceptable salt" refers to a salt of a compound of the present invention that is pharmaceutically acceptable and possesses the pharmacological activity of the parent compound. Such salts include acid addition salts formed with inorganic or organic acids, such as nitric, phosphoric, and carbonic acids; organic acids, such as propionic, hexanoic, cyclopentylpropionic, glycolic, pyruvic, gluconic, stearic, and muconic acids; salts formed when an acidic proton present in the parent compound is replaced by a metal ion, such as an alkali metal or alkaline earth metal ion; or coordination compounds formed with an organic base, such as ethanolamine. Pharmaceutically acceptable salts of the present invention can be synthesized from parent compounds containing acid or base groups by conventional chemical methods. Generally, such salts are prepared by reacting the free acid or base form of these compounds with a stoichiometric amount of an appropriate base or acid in water, an organic solvent, or a mixture of both. Generally, non-aqueous media, such as ether, ethyl acetate, ethanol, isopropanol, or acetonitrile, are preferred. In addition to salt forms, the compounds provided herein also exist in prodrug form. Prodrugs of the compounds described herein readily undergo chemical changes under physiological conditions to convert to the compounds of the invention. Additionally, prodrugs can be converted to the compounds of the invention by chemical or biochemical methods in an in vivo environment.

[0736] As used herein, the term "solvate" refers to a compound of the present invention in combination with a pharmaceutically acceptable solvent. Pharmaceutically acceptable solvents include acetic acid, etc. Solvates include stoichiometric solvates and non-stoichiometric solvates. Certain compounds of the present invention may exist in unsolvated or solvated forms. Generally speaking, solvated forms are equivalent to unsolvated forms and are encompassed by the present invention.

[0737] As used herein, the term "stereoisomer" includes conformational isomers and configurational isomers, wherein configurational isomers mainly include cis-trans isomers and optical isomers. The compounds of the present invention may exist in the form of stereoisomers, and therefore encompass all possible stereoisomeric forms, including but not limited to cis-trans isomers, tautomers, enantiomers, diastereomers, atropisomers, etc. The compounds of the present invention may also exist in the form of any combination or any mixture of the aforementioned stereoisomers, such as mesomorphs, racemates, equal mixtures of atropisomers, etc. For example, a single enantiomer, a single diastereomer or a mixture thereof, or a single atropisomer or a mixture thereof. When the compound of the present invention contains an olefin double bond, unless otherwise specified, it includes cis-isomers and trans-isomers, and any combination thereof. The atropisomers of the present invention are stereoisomers with axial or planar chirality based on restricted intramolecular rotation. And as a drug, stereoisomers with excellent activity are preferred. The compounds of the present invention have optical isomers arising from asymmetric carbon atoms, etc., and individual isomers can be resolved and obtained, if necessary, by methods known in the art, such as crystallization or chiral chromatography.

[0738] As used herein, the term "alkyl" refers to a straight-chain or branched saturated aliphatic hydrocarbon group. 1-20 "Alkyl" refers to a straight or branched chain alkyl group having 1 to 20 carbon atoms. Preferably, C 1-10 Alkyl. More preferably C 1-6 Alkyl (i.e., linear or branched alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms). More preferably, C 1-4 Alkyl. More preferably C 1-3Alkyl. Specific examples include, but are not limited to, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, sec-butyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 2-methylbutyl, 3-methylbutyl, n-hexyl, 1-ethyl-2-methylpropyl, 1,1,2-trimethylpropyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2-ethylbutyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 2,3-dimethylbutyl, and various branched isomers thereof. In the present invention, the alkyl group may be optionally substituted. When substituted, the substituent is preferably one or more of the substituent groups described in this application.

[0739] As used herein, the term "heteroalkyl" refers to an alkyl group in which at least one carbon atom is replaced by a heteroatom (e.g., an O, N, or S atom), wherein alkyl is as defined above. The heteroatom may be present in the middle or at the end of the group. In the present invention, the heteroalkyl group may be optionally substituted. When substituted, the substituent is preferably one or more of the substituent groups described in this application.

[0740] As used herein, the term "alkoxy" refers to a group having the structure -O-alkyl, wherein alkyl is as defined above. 1-10 "Alkoxy" refers to an alkoxy group having 1 to 10 carbon atoms. Preferably, C 1-6 Alkoxy. More preferably C 1-4 Alkoxy. More preferably C 1-3 Alkoxy. Specific examples include, but are not limited to, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, tert-butoxy, isobutoxy, n-pentoxy, and the like. In the present invention, the alkoxy group may be optionally substituted. When substituted, the substituent is preferably one or more of the substituent groups described in this application.

[0741] As used herein, the term "alkenyl" refers to an alkyl group as defined above having one or more carbon-carbon double bonds at any position of the chain. 2-8 "Alkenyl" refers to an alkenyl group having 2 to 8 carbon atoms and at least one (e.g., 1 to 2) carbon-carbon double bond. Preferably, C 2-6 Alkenyl (ie, alkenyl having 2 to 6 carbon atoms and 1 to 2 carbon-carbon double bonds). More preferably C 2-4 Alkenyl (i.e., an alkenyl group having 2 to 4 carbon atoms and 1 to 2 carbon-carbon double bonds). Specific examples include, but are not limited to, ethenyl, 1-propenyl, 2-propenyl, 1-, 2-, or 3-butenyl, pentenyl, hexenyl, butadienyl, and the like. In the present invention, the alkenyl group may be optionally substituted, and when substituted, the substituent is preferably one or more of the substituent groups described herein.

[0742] As used herein, the term "alkynyl" refers to an alkyl group as defined above having one or more carbon-carbon triple bonds at any position of the chain. 2-8 "Alkynyl" refers to an alkynyl group having 2 to 8 carbon atoms and at least one (e.g., 1 to 2) carbon-carbon triple bond. Preferably, C 2-6 Alkynyl (i.e., an alkynyl group having 2 to 6 carbon atoms and 1 to 2 carbon-carbon triple bonds). More preferably, C 2-4 Alkynyl (i.e., an alkynyl having 2 to 4 carbon atoms and 1 to 2 carbon-carbon triple bonds). Specific examples include, but are not limited to, ethynyl, 1-propynyl, 2-propynyl, 1-, 2-, or 3-butynyl, and the like. In the present invention, the alkynyl group may be optionally substituted, and when substituted, the substituent is preferably one or more of the substituent groups described herein.

[0743] As used herein, the term "halogen" refers to fluorine, chlorine, bromine, or iodine.

[0744] As used herein, the term "halo" refers to fluoro, chloro, bromo, or iodo.

[0745] As used herein, the term "haloalkyl" refers to an alkyl group in which one or more (e.g., 1, 2, 3, 4, or 5) hydrogen atoms are replaced by halogen, wherein alkyl is as defined above. 1-10 "Alkyl" refers to a halogenated alkyl group having 1 to 10 carbon atoms. Preferably, the halogenated C 1-6 Alkyl. More preferably halogenated C 1-4 Alkyl. More preferably halogenated C 1-3 Specific examples include, but are not limited to, monochloromethyl, dichloromethyl, trichloromethyl, monochloroethyl, 1,2-dichloroethyl, trichloroethyl, monobromoethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, and the like.

[0746] As used herein, the term "haloalkoxy" refers to an alkoxy group in which one or more (eg, 1, 2, 3, 4, or 5) hydrogen atoms are replaced by halogen, wherein the definition of alkoxy is as described above. 1-10 "Alkoxy" refers to a halogenated alkoxy group having 1 to 10 carbon atoms. Preferably, the halogenated C 1-6 Alkoxy. More preferably halogenated C 1-4 Alkoxy. More preferably halogenated C 1-3 Specific examples include, but are not limited to, trifluoromethoxy, trifluoroethoxy, monofluoromethoxy, monofluoroethoxy, difluoromethoxy, difluoroethoxy, and the like.

[0747] As used herein, the term "deuterated" refers to a group in which one or more hydrogen atoms are replaced by deuterium atoms.

[0748] As used herein, the term "deuterated alkyl" refers to an alkyl group in which one or more (e.g., 1, 2, 3, 4, or 5) hydrogen atoms are replaced by deuterium atoms, wherein the definition of alkyl is as described above. 1-10 "Alkyl" refers to a deuterated alkyl group having 1 to 10 carbon atoms. Preferably, it is a deuterated C 1-6 More preferably, deuterated C 1-4 More preferably, deuterated C 1-3 Specific examples include, but are not limited to, monodeuteriomethyl, dideuteriomethyl, trideuteriomethyl, monodeuterioethyl, 1,2-dideuterioethyl, trideuterioethyl, and the like.

[0749] As used herein, the term "deuterated alkoxy" refers to an alkoxy group in which one or more (e.g., 1, 2, 3, 4, or 5) hydrogen atoms are replaced by deuterium atoms, wherein the definition of alkoxy is as described above. 1-10 "Alkoxy" refers to a deuterated alkoxy group having 1 to 10 carbon atoms. Preferably, it is a deuterated C 1-6 Alkoxy. More preferably deuterated C 1-4 Alkoxy. More preferably deuterated C 1-3 Specific examples include, but are not limited to, trideutermethoxy, trideuterethoxy, monodeutermethoxy, monodeuterethoxy, dialdeutermethoxy, dialdeuterethoxy, and the like.

[0750] As used herein, the terms "cycloalkyl" and "cycloalkyl ring" are used interchangeably to refer to saturated monocyclic or polycyclic cyclic hydrocarbon groups, including, for example, monocyclic cycloalkyl, spirocycloalkyl, fused cycloalkyl and bridged cycloalkyl. The ring carbon atoms of the cycloalkyl group described in the present invention may be optionally substituted with 1, 2 or 3 oxo groups to form a cyclic ketone structure. The terms "3 to 20 membered cycloalkyl" or "C 3-20 "Cycloalkyl" refers to a cycloalkyl group having 3 to 20 ring carbon atoms, including monocyclic cycloalkyl, spirocyclic alkyl, fused cycloalkyl and bridged cycloalkyl. Preferably, C 3-12 Cycloalkyl, C 5-20 Spiroalkyl, C 5-20 Fused cycloalkyl or C 5-20 More preferably C 3-8 Monocyclic cycloalkyl.

[0751] The term "C 3-8 "Monocyclic cycloalkyl" and "3 to 8 membered monocyclic cycloalkyl" refer to saturated monocyclic hydrocarbon groups having 3 to 8 ring carbon atoms. Preferably, C 3-6 Monocyclic cycloalkyl (i.e., 3 to 6-membered monocyclic cycloalkyl) or C 4-6 Monocyclic cycloalkyl (i.e., 4- to 6-membered monocyclic cycloalkyl). More preferably, it is a C3, C4, C5, or C6 monocyclic cycloalkyl. Specific examples of monocyclic cycloalkyl include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and the like.

[0752] As used herein, the terms "spiroalkyl" and "spiroalkyl ring" refer to a polycyclic hydrocarbon group formed by two or more monocyclic rings sharing a carbon atom (called a spiro atom). Spiroalkyl groups are divided into monospiroalkyl, dispiroalkyl and polyspiroalkyl groups according to the number of spiro atoms shared between the rings. The terms "5- to 20-membered spiroalkyl" or "C 5-20 Spiroalkyl refers to a polycyclic hydrocarbon group having 5 to 20 ring carbon atoms, wherein the monocyclic ring sharing the spiro atom is a 3 to 8-membered monocyclic cycloalkyl ring. Preferably, the ring is a 6 to 14-membered (i.e., C 6-14 ) spirocycloalkyl. More preferably, it is a 6- to 14-membered monospirocycloalkyl. More preferably, it is a 7- to 11-membered (i.e., C 7- 11 ) spirocycloalkyl. More preferably, it is a 7- to 11-membered monospirocycloalkyl. Most preferably, it is a 7-membered (4-membered monocyclic cycloalkyl ring / 4-membered monocyclic cycloalkyl ring), an 8-membered (4-membered monocyclic cycloalkyl ring / 5-membered monocyclic cycloalkyl ring), a 9-membered (4-membered monocyclic cycloalkyl ring / 6-membered monocyclic cycloalkyl ring, a 5-membered monocyclic cycloalkyl ring / 5-membered monocyclic cycloalkyl ring), a 10-membered (5-membered monocyclic cycloalkyl ring / 6-membered monocyclic cycloalkyl ring) or an 11-membered (6-membered monocyclic cycloalkyl ring / 6-membered monocyclic cycloalkyl ring) monospirocycloalkyl. Specific examples of spirocycloalkyl include, but are not limited to:

[0753] These spirocycloalkyl groups may be attached to the rest of the molecule via any of the ring atoms.

[0754] As used herein, the terms "fused cycloalkyl" and "fused cycloalkyl ring" refer to a polycyclic hydrocarbon group formed by two or more monocyclic rings sharing a pair of adjacent carbon atoms. Depending on the number of rings formed, fused cycloalkyl groups can be classified as bicyclic, tricyclic, tetracyclic or polycyclic. The terms "5- to 20-membered fused cycloalkyl" or "C 5-20 "Fused cycloalkyl" refers to a polycyclic hydrocarbon group having 5 to 20 ring carbon atoms, wherein the monocyclic ring sharing adjacent carbon atom pairs is a 3 to 8-membered monocyclic cycloalkyl ring. Preferably, the monocyclic ring is a 6 to 14-membered (i.e., C 6-14 ) fused cycloalkyl. More preferably, it is a 6- to 14-membered difused cycloalkyl. More preferably, it is a 7- to 10-membered (i.e., C 7-10 ) fused cycloalkyl. More preferably, it is a 7- to 10-membered di-fused cycloalkyl. Most preferably, it is an 8-membered (5-membered monocyclic cycloalkyl ring fused to a 5-membered monocyclic cycloalkyl ring), 9-membered (5-membered monocyclic cycloalkyl ring fused to a 6-membered monocyclic cycloalkyl ring), or 10-membered (6-membered monocyclic cycloalkyl ring fused to a 6-membered monocyclic cycloalkyl ring) di-fused cycloalkyl. Specific examples of fused cycloalkyl groups include, but are not limited to:

[0755] These fused cycloalkyl groups may be attached to the rest of the molecule via any one of the ring atoms.

[0756] As used herein, the terms "bridged cycloalkyl" and "bridged cycloalkyl ring" refer to a polycyclic hydrocarbon group formed by sharing two carbon atoms that are not directly connected between two or more monocyclic rings. Depending on the number of rings formed, it can be divided into bicyclic, tricyclic, tetracyclic or polycyclic bridged cycloalkyl groups. The terms "5- to 20-membered bridged cycloalkyl" and "C 5-20 "Bridged cycloalkyl" refers to a polycyclic hydrocarbon group having 5 to 20 ring carbon atoms, wherein any two rings share two carbon atoms that are not directly connected. Preferably, the cycloalkyl group is 6 to 14 members (i.e., C 6-14 ) bridged cycloalkyl. More preferably 7 to 10 members (ie C 7-10 ) bridged cycloalkyl. Specific examples of bridged cycloalkyl include, but are not limited to:

[0757] These bridged cycloalkyl groups can be attached to the rest of the molecule via any ring atom.

[0758] In the present invention, the cycloalkyl group may be optionally substituted. When substituted, the substituent is preferably one or more substituent groups described in this application.

[0759] As used herein, the term "halocycloalkyl" refers to a cycloalkyl group in which one or more (eg, 1, 2, 3, 4, or 5) hydrogen atoms are replaced by a halogen, wherein cycloalkyl is as defined above.

[0760] As used herein, the term "halogenated C 3-8 "Monocyclic cycloalkyl" refers to a halogenated monocyclic cycloalkyl group having 3 to 8 ring carbon atoms. Preferably, the halogenated C 3-6 Monocyclic cycloalkyl. More preferably, it is a halogenated C3, halogenated C4, halogenated C5 or halogenated C6 monocyclic cycloalkyl. Specific examples include, but are not limited to, trifluorocyclopropyl, monofluorocyclopropyl, monofluorocyclohexyl, difluorocyclopropyl, difluorocyclohexyl, etc.

[0761] As used herein, the terms "heterocyclyl" and "heterocyclyl ring" are used interchangeably to refer to saturated or partially unsaturated monocyclic or polycyclic cyclic hydrocarbon groups, including, for example, monocyclic heterocyclyls, spiro heterocyclyls, fused heterocyclyls, and bridged heterocyclyls. The ring carbon atoms of the heterocyclyl group described in the present invention may be optionally substituted with 1, 2, or 3 oxo groups to form a cyclic ketone, cyclic lactone, or cyclic lactam structure. The term "3 to 20 membered heterocyclyl" refers to a saturated or partially unsaturated monocyclic or polycyclic cyclic hydrocarbon group having 3 to 20 ring atoms, wherein one or more (preferably 1, 2, 3, or 4) ring atoms are selected from nitrogen, oxygen, or S(=O). m' (wherein m' is an integer from 0 to 2) heteroatoms, excluding the ring portion of -OO-, -OS- or -SS-, and the remaining ring atoms are carbon. Wherein, when the ring atom is a nitrogen atom, it may be substituted or unsubstituted (i.e., N or NR, R is hydrogen or other substituents as defined herein). The 3 to 20 membered heterocyclyl of the present invention includes monocyclic heterocyclyl (e.g., 3 to 8 membered monocyclic heterocyclyl), 5 to 20 membered spiro heterocyclyl, 5 to 20 membered fused heterocyclyl and 5 to 20 membered bridged heterocyclyl.

[0762] As used herein, the terms "3 to 8 membered monocyclic heterocyclyl", "3 to 8 membered monocyclic heterocyclyl" and "3 to 8 membered monocyclic heterocyclyl ring" refer to a group having 3 to 8 ring atoms, wherein 1, 2 or 3 of the ring atoms are selected from nitrogen, oxygen or S(=O). m ' (wherein m' is an integer from 0 to 2) is a saturated or partially unsaturated monocyclic hydrocarbon group containing a heteroatom. Preferably, it is a 3- to 6-membered monocyclic heterocyclic group having 3 to 6 ring atoms, wherein 1 or 2 ring atoms are heteroatoms. More preferably, it is a 4- to 6-membered monocyclic heterocyclic group having 4 to 6 ring atoms, wherein 1 or 2 ring atoms are heteroatoms. More preferably, it is a 5- or 6-membered monocyclic heterocyclic group having 5 or 6 ring atoms, wherein 1 or 2 ring atoms are heteroatoms. When the heteroatom is a nitrogen atom, the nitrogen atom may be substituted or unsubstituted (i.e., N or NR, R is hydrogen or other substituents defined herein). When the heteroatom is a sulfur atom, the sulfur atom may be optionally oxidized (i.e., S(=O) m', m' is an integer from 0 to 2). The ring carbon atoms of the monocyclic heterocyclic group may be optionally substituted by 1, 2 or 3 oxo groups to form a cyclic ketone, cyclic lactone or cyclic lactam structure. Specific examples of monocyclic heterocyclic groups include, but are not limited to, aziridine, oxirane, azetidine, azetidine-2-one, oxetane, oxetane-2-one, oxazolidine, pyrrolidone, pyrrolidine-2,5-dione, 1,3-dioxolane, dihydrofuran-2(3H)-one, dihydrofuran-2,5-dione, piperidine-2-one, piperidine-2,6-dione, tetrahydro-2H-pyran-2-one, imidazolidine, tetrahydrofuran, tetrahydrothiophene, tetrahydropyrrole, 1,3-dioxolane-2-one, oxazolidin-2-one, imidazolidin-2-one, piperidine, piperazine, piperazin-2-one, morpholine, morpholine-3-one, morpholine-2-one, thiophene ... Morpholin-3-one 1,1-dioxide, thiomorpholine, thiomorpholine-1,1-dioxide, tetrahydropyran, 1,2-dihydroazetadiene, 1,2-dihydrooxetadiene, 2,5-dihydro-1H-pyrrole, 2,5-dihydrofuran, 2,3-dihydrofuran, 2,3-dihydro-1H-pyrrole, 3,4-dihydro-2H-pyran, 1,2,3,4-tetrahydropyridine, 3,6-dihydro-2H-pyran, 1,2,3,6-tetrahydropyridine, 1,3-oxazinane, hexahydropyrimidine, 1,4-dioxane, tetrahydropyrimidin-2(1H)-one, 1,4-dioxane-2-one, 5,6-dihydro-2H-pyran-2-one, 5,6-dihydropyrimidin-4(3H)-one, 3,4-dihydropyridin-2(1H)-one, 5,6-dihydropyridin-2(1H)-one, 5,6-dihydropyrimidin-4(1H)-one, pyrimidin-4(3H)-one, pyrimidin-4(1H)-one, 4,5-dihydro-1H-imidazole, 2,3-dihydro-1H-imidazole, 2,3-dihydrooxazole, 1,3-dioxole, 2,3-dihydrothiophene, 2,5-dihydrothiophene, 3,4-dihydro-2H-1,4-oxazine, 3,4-dihydro-2H-1,4-thiazine 1,1-dioxide, 1,2,3,4-tetrahydropyrazine, 1,3-dihydro-2H-pyrrole-2- Ketone, 1,5-dihydro-2H-pyrrol-2-one, 1H-pyrrole-2,5-dione, furan-2(3H)-one, furan-2(5H)-one, 1,3-dioxol-2-one, oxazole-2(3H)-one, 1,3-dihydro-2H-imidazole-2-one, furan-2,5-dione, 3,6-dihydropyridine-2(1H)-one, pyridine-2,6-(1H,3H)-dione, 5,6-dihydro-2H-pyran-2-one, 3,6-dihydro-2H-pyran-2-one, 3,4-dihydro-2H-1,3-oxazine, 3,6-dihydro-2H-1,3-oxazine, 1,2,3,4-tetrahydropyrimidine, etc.

[0763] As used herein, the term "3- to 6-membered nitrogen-containing heterocyclic group" refers to a group having 3 to 6 ring atoms, wherein one ring atom is a nitrogen atom and the other one or two ring atoms are selected from nitrogen, oxygen or S(=O). m m' is an integer from 0 to 2. Specific examples include, but are not limited to, aziridine, azetidinyl, azopentyl (i.e., tetrahydropyrrole), azohexyl (i.e., hexahydropyridine), morpholinyl, piperazinyl, and oxazolidine.

[0764] As used herein, the term "3- to 8-membered monocyclic heterocycloalkyl" refers to a saturated monocyclic hydrocarbon group having 3 to 8 ring atoms, 1 or 2 of which are heteroatoms. Preferably, it is a 3- to 6-membered monocyclic heterocycloalkyl group, i.e., a saturated monocyclic hydrocarbon group having 3 to 6 ring atoms, 1 or 2 of which are heteroatoms. Specific examples of heterocycloalkyl include, but are not limited to, aziridine, oxiranyl, azetidinyl, oxetanyl, oxazolidinyl, 1,3-dioxolane, dioxane, imidazolidinyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, thiomorpholine-1,1-dioxide, tetrahydropyranyl, 1,4-oxazepanyl, 1,3-oxazinyl, hexahydropyrimidinyl, and 1,4-dioxanyl.

[0765] The two ring atoms connected to the monocyclic heterocyclyl ring, including C—C and C—N, can be optionally fused with a cycloalkyl, heterocyclyl, aryl, or heteroaryl group, such as a monocyclic cycloalkyl ring, a monocyclic heterocyclyl ring, a monoaryl ring, a 5- or 6-membered monocyclic heteroaryl ring, as defined herein, to form a fused polycyclic ring. The two ring atoms connected to the monocyclic heterocyclyl ring forming a fused ring with another ring are preferably C—C.

[0766] As used herein, the terms "spiroheterocyclyl" and "spiroheterocyclyl ring" refer to a polycyclic heterocyclic group formed by two or more saturated or partially unsaturated monocyclic rings sharing a carbon atom (called a spiro atom), wherein one or more (e.g., 1, 2, or 3) ring atoms are selected from nitrogen, oxygen, or S(=O). m' (wherein m' is an integer from 0 to 2) heteroatom, and the remaining ring atoms are carbon. When the heteroatom is a nitrogen atom, the nitrogen atom can be substituted or unsubstituted (i.e. N or NR, R is hydrogen or other substituents defined herein). Each monocycle can contain one or more double bonds, but no ring has a completely conjugated π electron system. Spiro heterocyclic groups are divided into monospiro heterocyclic groups, dispiro heterocyclic groups or polyspiro heterocyclic groups according to the number of shared spiro atoms between the rings. The term "5 to 20 yuan spiro heterocyclic group" refers to a spiro heterocyclic group with 5 to 20 ring atoms, wherein one monocycle in the monocycle sharing the spiro atom is a 3 to 8 yuan monocyclic heterocyclic ring, and the other monocycle is a 3 to 8 yuan monocyclic heterocyclic ring or a 3 to 8 yuan monocyclic cycloalkyl ring. Preferably, there are 6 to 14 ring atoms, wherein 1 or 2 ring atoms are 6 to 14 yuan spiro heterocyclic groups with heteroatoms. More preferably, it is a 7 to 11-membered spiro heterocyclic radical having 7 to 11 ring atoms, wherein 1 or 2 ring atoms are heteroatoms. Most preferably, it is a 7-membered (4-membered monocyclic heterocyclic radical ring / 4-membered monocyclic heterocyclic radical ring or 4-membered monocyclic heterocyclic radical ring / 4-membered monocyclic cycloalkyl or 4-membered monocyclic cycloalkyl ring / 4-membered monocyclic heterocyclic radical ring), an 8-membered (4-membered monocyclic heterocyclic radical ring / 5-membered monocyclic heterocyclic radical ring), a 9-membered (4-membered monocyclic heterocyclic radical ring / 6-membered monocyclic heterocyclic radical ring, a 5-membered monocyclic heterocyclic radical ring / 5-membered monocyclic heterocyclic radical ring), a 10-membered (5-membered monocyclic heterocyclic radical ring / 6-membered monocyclic heterocyclic radical ring) or an 11-membered (6-membered monocyclic heterocyclic radical ring / 6-membered monocyclic heterocyclic radical ring) monospiro heterocyclic radical. Specific examples of spiro heterocyclic radicals include, but are not limited to:

[0767] These spiroheterocyclyl groups may be attached to the rest of the molecule via any suitable ring atom.

[0768] As used herein, the terms "fused heterocyclyl" and "fused heterocyclyl ring" refer to a polycyclic heterocyclyl formed by two or more saturated or partially unsaturated monocyclic rings sharing a pair of adjacent ring atoms, wherein one or more (e.g., 1, 2, or 3) ring atoms are selected from nitrogen, oxygen, or S(=O). m' (wherein m' is an integer from 0 to 2) heteroatom, and the remaining ring atoms are carbon. When the heteroatom is a nitrogen atom, the nitrogen atom may be substituted or unsubstituted (i.e., N or NR, R is hydrogen or other substituents defined herein). Each monocyclic ring may contain one or more double bonds, but no ring has a completely conjugated π electron system. The shared adjacent ring atom pairs may be CC or NC. Depending on the number of constituent rings, it can be divided into bicyclic, tricyclic, tetracyclic or polycyclic fused heterocyclic groups. The term "5 to 20 membered fused heterocyclic group" refers to a fused heterocyclic group having 5 to 20 ring atoms, wherein the monocyclic ring sharing adjacent ring atom pairs is a 3 to 8 membered monocyclic heterocyclic ring. Preferably, it is a 6 to 14 membered fused heterocyclic group having 6 to 14 ring atoms, wherein 1 or 2 ring atoms are heteroatoms. More preferably, it is a 6 to 10 membered fused heterocyclic group having 6 to 10 ring atoms, wherein 1 or 2 ring atoms are heteroatoms. More preferably, it is an 8- to 10-membered fused heterocyclic group having 8 to 10 ring atoms, of which 1 or 2 ring atoms are heteroatoms. Most preferably, it is an 8-membered (5-membered monocyclic heterocyclic ring fused to a 5-membered monocyclic heterocyclic ring), a 9-membered (5-membered monocyclic heterocyclic ring fused to a 6-membered monocyclic heterocyclic ring) or a 10-membered (6-membered monocyclic heterocyclic ring fused to a 6-membered monocyclic heterocyclic ring) bicyclic fused heterocyclic group. Specific examples of fused heterocyclic groups include, but are not limited to:

[0769] These fused heterocyclic groups may be attached to the rest of the molecule through any suitable ring atom.

[0770] As used herein, the terms "bridged heterocyclyl" and "bridged heterocyclyl ring" refer to a polycyclic heterocyclyl formed by two or more saturated or partially unsaturated monocyclic rings sharing two ring atoms that are not directly connected, wherein one or more (e.g., 1, 2, or 3) ring atoms are selected from nitrogen, oxygen, or S(=O). m ' (wherein m' is an integer from 0 to 2) heteroatoms, and the remaining ring atoms are carbon. According to the number of rings formed, it can be divided into bicyclic, tricyclic, tetracyclic or polycyclic bridged cycloalkyl groups. The term "5 to 20 membered bridged heterocyclic group" refers to a saturated or partially unsaturated polycyclic heterocyclic group having 5 to 20 ring atoms, wherein any two rings share two ring atoms that are not directly connected, each monocyclic ring may contain one or more double bonds, but no ring has a completely conjugated π electron system. Preferably it is a 6 to 14 membered bridged heterocyclic group. More preferably it is a 7 to 10 membered bridged heterocyclic group. Specific examples of bridged heterocyclic groups include, but are not limited to:

[0771] These bridged heterocyclic groups may be attached to the rest of the molecule via any suitable ring atom.

[0772] In the present invention, the various heterocyclic groups mentioned above may be optionally substituted. When substituted, the substituents are preferably one or more substituent groups described in this application.

[0773] The term "5- to 15-membered tricyclic heterocyclic group" refers to a tricyclic heterocyclic group having 5 to 15 ring atoms, wherein the three rings may be connected by one or more means selected from spiro-connection, fusion connection, and bridge connection. Specific examples include, but are not limited to, a first monocyclic ring being a 6-membered monocyclic heterocyclic ring, a second monocyclic ring being a 6-membered monocyclic heterocyclic ring, and a third monocyclic ring being a 3- to 6-membered monocyclic heterocyclic ring; wherein the first monocyclic ring is fused to the second monocyclic ring, and the third monocyclic ring is spiro-connected to the second monocyclic ring.

[0774] The term "7- to 12-membered bicyclic heterocyclic group" refers to a bicyclic heterocyclic group having 7 to 12 ring atoms, wherein the two rings are connected by a method selected from spiro, fused, and bridged. Specific examples can be selected from the specific examples of spiro heterocyclic groups, fused heterocyclic groups, and bridged heterocyclic groups described above.

[0775] The term "9- to 11-membered bicyclic heterocyclic group" refers to a bicyclic heterocyclic group having 9 to 11 ring atoms, wherein the two rings are connected by a method selected from spiro, fused, and bridged. Specific examples can be selected from the specific examples of the above-mentioned spiro heterocyclic group, the specific examples of the fused heterocyclic group, and the specific examples of the bridged heterocyclic group.

[0776] As used herein, the terms "aryl", "aryl ring" and "aromatic ring" are used interchangeably to refer to an all-carbon monocyclic, all-carbon non-fused polycyclic (rings are connected by covalent bonds and are not fused) or all-carbon fused polycyclic (i.e., rings that share adjacent pairs of carbon atoms) group, wherein at least one ring in the group is aromatic, i.e., has a conjugated π electron system. The term "C 6-14 "Aryl" refers to an aromatic group having 6 to 14 ring atoms. Preferably, C 6-10 Aryl. In the present invention, C 6-14 The aryl group includes a monocyclic aryl group, a non-condensed polycyclic aryl group, and an aromatic condensed polycyclic group. Examples of the monocyclic aryl group include a phenyl group, and examples of the non-condensed polycyclic aryl group include a biphenyl group.

[0777] In the present invention, when C 6-14 When the aryl group is an aromatic fused polycyclic ring, the aromatic fused polycyclic ring may be a polycyclic group formed by condensing a single aryl ring with one or more single aryl rings, and non-limiting examples thereof include naphthyl, anthracenyl, and the like.

[0778] In some embodiments of the present invention, when C 6-14When the aromatic group is an aromatic fused polycyclic ring, the aromatic fused polycyclic ring may also be a polycyclic group formed by the fusion of a single aromatic ring (such as a phenyl group) and one or more non-aromatic rings, wherein the ring connected to the parent structure is an aromatic ring or a non-aromatic ring. The non-aromatic ring includes but is not limited to a 3- to 6-membered monocyclic heterocyclic ring (preferably a 5- or 6-membered monocyclic heterocyclic ring, the ring carbon atoms of which may be substituted by 1 to 2 oxo groups to form a cyclic lactam or cyclic lactone structure), a 3- to 6-membered monocyclic cycloalkyl ring (preferably a 5- or 6-membered monocyclic cycloalkyl ring, the ring carbon atoms of which may be substituted by 1 or 2 oxo groups to form a cyclic ketone structure). The polycyclic group in which the above-mentioned single aromatic ring is fused to one or more non-aromatic rings may be connected to other groups or the parent structure through nitrogen atoms or carbon atoms, and the ring connected to the parent structure is a single aromatic ring or a non-aromatic ring.

[0779] In the present invention, the above-mentioned various aryl groups may be substituted or unsubstituted. When substituted, the substituent is preferably one or more substituent groups described in this application.

[0780] As used herein, the terms "heteroaryl", "heteroaryl ring" and "heteroaromatic ring" are used interchangeably and refer to monocyclic or fused polycyclic (i.e., sharing adjacent pairs of ring atoms, where the shared adjacent pairs of ring atoms can be CC or NC) groups in which the ring atoms are substituted by at least one heteroatom independently selected from nitrogen, oxygen or sulfur, wherein the nitrogen and sulfur atoms can be optionally oxidized and the nitrogen atom can be optionally quaternized. The heteroaryl group has 6, 10 or 14 shared π electrons, and at least one ring in the group is aromatic. The term "5- to 14-membered heteroaryl" refers to a group having 5 to 14 ring atoms, wherein 1, 2, 3, 4 or 5 ring atoms are selected from nitrogen, oxygen or S(=O) m The heteroaryl group is preferably a 5- to 10-membered heteroaryl group having 5 to 10 ring atoms, of which 1, 2, 3 or 4 ring atoms are heteroatoms. The 5- to 14-membered heteroaryl group of the present invention may be a monocyclic heteroaryl group, a fused bicyclic heteroaryl group or a fused tricyclic heteroaryl group.

[0781] As used herein, the term "5- or 6-membered monocyclic heteroaryl" refers to a group having 5 or 6 ring atoms, wherein 1, 2 or 3 ring atoms are selected from nitrogen, oxygen or S(=O). m m' (wherein m' is an integer from 0 to 2). Specific examples of monocyclic heteroaryl groups include, but are not limited to, thiophene, furan, thiazole, isothiazole, imidazole, oxazole, pyrrole, pyrazole, triazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,5-triazole, 1,3,4-triazole, tetrazole, isoxazole, oxadiazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine, and the like.

[0782] As used herein, the term "8- to 10-membered bicyclic heteroaryl" refers to a bicyclic heteroaryl group having 8 to 10 ring atoms, wherein 1, 2, 3, 4 or 5 ring atoms are selected from nitrogen, oxygen or S(=O). m The fused bicyclic heteroaryl group may be a bicyclic group (preferably a 9- or 10-membered bicyclic heteroaryl ring) formed by the fusion of a monocyclic heteroaryl ring (such as a phenyl group) and a monocyclic heteroaryl ring (preferably a 5- or 6-membered monocyclic heteroaryl ring), or a bicyclic group (preferably a 5- or 6-membered monocyclic heteroaryl ring) and a monocyclic heteroaryl ring (preferably a 5- or 6-membered monocyclic heteroaryl ring).

[0783] Any two connected ring atoms on the monocyclic heteroaryl ring, including CC, NC, and NN, can be fused with a cycloalkyl, heterocyclyl, aryl, or heteroaryl group, such as a monocyclic cycloalkyl ring, a monocyclic heterocyclyl ring, a monoaryl ring, a 5- or 6-membered monocyclic heteroaryl ring, to form a fused polycyclic ring. The two connected ring atoms on the monocyclic heteroaryl ring forming ...

Claims

A compound represented by formula (I) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: Where, for X is Y1 is N, CH, or CR 4a , CR 4b or CR5; where N can be oxidized (N + -O - ); Y2 is N, CH, CR 4a , CR 4b or CR5; where N can be oxidized (N + -O - );R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 Cycloalkyl or substituted or unsubstituted 3 to 8 membered heterocyclic group; L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl; R 00 is hydrogen or C 1-6 Alkyl; R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 Heteroalkyl; R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 Heteroalkyl; R 3a C 1-6 Alkyl or deuterated C 1-6 Alkyl; R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, or -P(=O)-(C 1-6 Alkyl)2; R 4a is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 Cycloalkyl or substituted or unsubstituted 3 to 8-membered heterocyclic group; R 4b is deuterium, halogen, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl; R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-N(R 06 )C(=O)-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-NR 01 R 02 、-OC 1-4 Alkyl-C(R 05 )R 03 R 04 、-OC 1-4 Alkyl-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 、-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenyl-NR 01 R 02 、-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkenyl-C(R 05 )R 03 R 04 、-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkenyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkenyl-C 1-4 Alkyl-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkyl-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkyl-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 alkyl-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkyl-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)(-C 1-4 Alkyl-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkyl-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkyl-C(R 05 )R 03 R 04 );R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 Alkyl) 3-Si-; or, R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or R 01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or R 03 、R 04 Together with the carbon atom to which it is attached, R forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group; 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 Alkyl; R 06 is hydrogen, deuterium or C 1-6 Alkyl; Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkyl-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkyl-N=S(=O)(R 07 )(R 08 ) or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 Alkyl; or Y3, R 12 and the nitrogen atom to which they are attached together form a substituted or unsubstituted nitrogen-containing 3 to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3 to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (such as 1, 2 or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; R6 is a substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl; R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl; R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; R 08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; or R 07 and R 08 Together with the atoms to which it is attached, it forms a substituted or unsubstituted 3- to 8-membered heterocyclic group; Y5 is O or S; Y4 is O or S; R 13 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl or -P(=O)-(C 1-6 Alkyl)2; R 14 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl or -P(=O)-(C 1-6 alkyl)2; or R 13 and R 14 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 Cycloalkyl or substituted or unsubstituted 3 to 8 membered heterocyclic group; in each of the above groups, the substitution means that the above groups are independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from S1 group; the groups of S1 group are independently selected from the following groups: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-hydroxyl, -OC 1-4 Alkyl-cyano, -OC 1-4 Alkyl-C 1-6 Alkyl, -OC 1-4 Alkyl-C 1-6 Alkoxy, -OC 1-4 Alkyl-C 3-20 Cycloalkyl, -OC 1-4 Alkyl-OC 3-20 Cycloalkyl, -OC 1-4 Alkyl-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkyl-C 6-14 Aryl, -OC 1-4 Alkyl-OC 6-14 Aryl, -OC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkyl-R c1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkyl-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-N=S(=O)(R g1 )(R h1 )、-P(=O)-(C 1-6 alkyl)2; wherein, The C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2; the nitrogen atom in the 5- or 6-membered monocyclic heteroaryl group may be optionally oxidized (N + -O - ); In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl) 2; In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; in the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl) 2; In the above groups, R g1 、R h1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R g1 、R h1 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; in the above groups, each group of S2 is independently selected from the following group: deuterium, oxo (C=O), thio (=S), =CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, cyano, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5; In the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl group substituted; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or C 1-4 The two hydrogen atoms on the same carbon atom of the alkyl group are simultaneously replaced by =CR e R f Substituted; In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; in the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; in the above groups, one or more (such as 1, 2, 3 or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; the C 1-6 One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus. or 5) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more (such as 1, 2, 3 or 4) ring atoms of the 3 to 6 membered monocyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 5 to 15 membered tricyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 6 to 12 membered heteroaryl and heterocycloalkyl are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 6 to 12 membered heteroaryl and heterocyclyl are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two heteroatoms selected from oxo and =NR e The group substituted; R e Same as above; wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same as above; provided that, when R6 is dimethylcyclopropyl, Y4 is O, Y5 is O, R1, R2 are hydrogen, L1 is thiazole, R 42 、R 43 is methyl, R 13 、R 14 When R3 is ethyl, R5 is not methylpiperazinyl. The compound according to claim 1, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is represented by formula (A) or formula (A'): Where R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl; and R 42 and R 43 are not methyl at the same time; or R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 Cycloalkyl or substituted or unsubstituted 3 to 8 membered heterocyclic group; L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl; R 00 is hydrogen or C 1-6 Alkyl; R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 Heteroalkyl; R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl; R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl; R4 is C 1-6 Alkyl or deuterated C 1-6 Alkyl; R 41 C 1-6 Alkyl or deuterated C 1-6 Alkyl; R5 is -NR 01 R 02 or -C(R 05 )R 03 R 04 ; R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group; the 5- to 15-membered tricyclic heterocyclic group has, in addition to the existing nitrogen atom, 0 or more (e.g., 0, 1, 2, 3, 4 or 5) ring atoms selected from nitrogen, oxygen or sulfur heteroatoms; R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 9- to 11-membered bicyclic heterocyclic group, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, or sulfur; R 05 is hydrogen, deuterium or C 1-6 Alkyl; R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl; the substitutions independently refer to 1, 2, 3 or 4 hydrogen atoms on the above groups being replaced by groups selected from Group S1; the groups in Group S1 are independently selected from the following groups: deuterium, oxo (=O), thioxo (=S), ═CR e R f , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkyl-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkyl-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkyl-C 6-14 Aryl, -C≡CC 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-C 3-20 Cycloalkyl, -C 1-4 Alkyl-OC 3-20 Cycloalkyl, -C 1-4 alkyl-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-O-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C 6-14 Aryl, -C 1-4 Alkyl-OC 6-14 Aryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-OR c1 、-C 1-4 Alkyl-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkyl-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkyl-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkyl-C(=O)OC 1-6 Alkyl, -C 1-4 Alkyl-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 1-6 Alkyl, -C 1-4 Alkyl-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkyl-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1-6 alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-NR a1 R b1 、-C 1-4 Alkyl-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkyl-C(=O)-NR a1 R b1 、-C 1-4 Alkyl-OR c1 、-C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkyl-NR d1 -C(=O)-R c1 、-C 1-4 Alkyl-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-R c1 、-C 1-4 Alkyl-S(=O)2-NR a1 R b1 、-C 1-4 Alkyl-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 ; wherein, the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2; in each of the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkyl-hydroxyl, -C 1-4 Alkyl-cyano, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkyl-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl) 2; In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; in the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkyl, -C 1-4 Alkyl-deuterated C 1-6 Alkyl, -C 1-4 Alkyl-C 1-6 Alkoxy, -C 1-4 Alkyl-halide C 1-6 Alkoxy, -C 1-4 Alkyl-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkyl-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkyl-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkyl-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkyl-phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkyl-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkyl-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl) 2; in the above groups, each group of S2 is independently selected from the following groups: oxo (C=O), thio (=S), =CR e R f , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkyl-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl; in the above groups, the -C 1-4 Alkyl- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkyl group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -CH2-hydroxy, -CH2-cyano, phenyl or -C 1-4 The two hydrogen atoms on the same carbon atom of an alkyl group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; in the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; in the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; in the above groups, one or more (such as 1, 2, 3 or 4) ring atoms of the 3 to 8 membered heterocyclic group are heteroatoms selected from nitrogen, oxygen or sulfur; 1-6 One or more (e.g., 1, 2, 3, or 4) atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 9- to 11-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, or sulfur; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, or sulfur; 5) ring atoms are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3 or 4) ring atoms of the 5- or 6-membered monocyclic heteroaryl are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3, 4 or 5) ring atoms of the 8- to 10-membered bicyclic heteroaryl are heteroatoms selected from nitrogen, oxygen or sulfur; one or more (such as 1, 2, 3 or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl are heteroatoms selected from nitrogen, oxygen or sulfur. The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is represented by formula (A-1), formula (A-2), formula (A'-1) or formula (A'-2): Wherein, R1, R2, R3, R4, R5, R6, and L1 are defined as above. The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is represented by formula (A-3) or formula (A'-3): Wherein, R1, R2, R3, R4, R5, R6, and L1 are defined as above. The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R4 is methyl or deuterated methyl. The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R5 is -C 2-4 Alkynyl-NR 01 R 02 、-C 2-4 Alkynyl-C(=O)-NR 01 R 02 、-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-NR 01 R 02 、-C 1-4 Alkyl-C 2-4 Alkynyl-C(R 05 )R 03 R 04 、-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 、-C 2-4 Alkynyl-C 1-4 Alkyl-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-C 2-4 Alkynyl-C 1-4 Alkyl-NR 01 R 02 . The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R5 is Among them, R 011 、R 012 are independently hydrogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R 011 、R 012 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 Cycloalkyl; the substitution is as defined above; X1 is a bond, S, O or N (R 013 );R 013 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 Alkyl; R 05 is hydrogen, deuterium or C 1-6 alkyl. The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R3 is hydrogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl. The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R1 is hydrogen, C 1-6 Alkoxy or deuterated C 1-6 Alkoxy; R2 is hydrogen. The compound according to claim 1 or 2, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, L1 is a 5- or 6-membered monocyclic heteroaryl group. The compound according to claim 1, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is shown in formula (C): Wherein, Y1, Y2, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 , L1 are defined as before. The compound according to claim 1, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is shown in formula (D): Wherein, Y1, Y2, R1, R2, R3, R4, R5, R 11 、R 41 、R 42 、R 43 , L1 are defined as before. The compound according to claim 12, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is represented by formula (D-1), formula (D-2), formula (D-3), formula (D-4), formula (D'-1), formula (D'-2), formula (D'-3) or formula (D'-4): Wherein, R1, R2, R3, R4, R5, R 41 、R 42 、R 43 、R 11 、L1, the definitions are the same as before. The compound according to claim 1, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is shown in formula (E): Wherein, R1, R2, R3, R4, R5, R6, R 41 、R 42 、R 43 , Y1, Y2, L1, are defined as before. The compound according to claim 14, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is represented by formula (E1) or (E2): Wherein, R1, R2, R3, R4, R5, R6, R 41 、L1, the definitions are the same as before. The compound according to claim 1, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is represented by formula (F) or formula (G): Wherein, R1, R2, R3, R4, R6, R 41 、R 42 、R 43 、R 11 , Y1, Y2, L1, respectively defined as above; R 15 Selected from-NR 01 R 02 、-C(=O)-NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkyl-NR 01 R 02 or -C 1-4 Alkyl-C(R 05 )R 03 R 04 ; R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl or (substituted or unsubstituted C 1-6 Alkyl) 3-Si-; or, R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; or R 01 、R 02 Jointly formed R 001 、R 002 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or R 03 、R 04 Together with the carbon atom to which it is attached, R forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl group, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl group; 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 Alkyl; the substitutions independently refer to 1, 2, 3 or 4 hydrogen atoms on the above groups being replaced by groups selected from S1 group; the groups in S1 group are as defined above. The compound according to claim 1 or 12, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R5 is hydrogen, [Corrected 01.02.2024 in accordance with Rule 26] A compound according to claim 1 or 12, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R 11 Select from the following groups: [Corrected 01.02.2024 in accordance with Rule 26] A compound according to claim 1 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R 11 is pyrrolidinyl, oxazolyl, isoxazolyl, dihydrooxazolyl, triazolyl, pyridazinyl, triazolopyridinyl, tetrahydrotriazolopyridinyl or triazolomorpholinyl, wherein the pyrrolidinyl, oxazolyl, isoxazolyl, dihydrooxazolyl, triazolyl, pyridazinyl, triazolopyridinyl, tetrahydrotriazolopyridinyl or triazolomorpholinyl is optionally selected from oxo, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, -C 1-4 The substituent of the alkyl-5 or 6-membered heteroaryl group is substituted. [Corrected 01.02.2024 in accordance with Rule 26] A compound according to claim 1 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, Select from the following groups: [Corrected 01.02.2024 in accordance with Rule 26] A compound according to claim 1 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, R6 is [Corrected 01.02.2024 in accordance with Rule 26] A compound according to claim 1 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein, The compound is selected from Table A or the compounds of Examples. [Corrected 01.02.2024 in accordance with Rule 26] A pharmaceutical composition comprising a compound according to any one of claims 1 to 22, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof; and a pharmaceutically acceptable carrier. [Corrected 01.02.2024 in accordance with Rule 26] Use of a compound according to any one of claims 1 to 22, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, or a pharmaceutical composition according to claim 23, in the preparation of a medicament for preventing and / or treating a disease or condition associated with RAS protein activity. [Corrected 01.02.2024 according to Rule 26] The use according to claim 24, wherein The disease or disorder associated with RAS protein activity is cancer. [Corrected 01.02.2024 according to Rule 26] The use according to claim 25, wherein The cancer is pancreatic cancer, colorectal cancer, non-small cell lung cancer, acute myeloid leukemia, multiple myeloma, thyroid adenocarcinoma, myelodysplastic syndrome, squamous cell lung cancer, esophageal cancer, ovarian cancer, uterine cancer, melanoma, bladder cancer or head and neck cancer.

Images