An antiperspirant deodorant composition and its use in a male antiperspirant deodorant product

Abstract

The present application relates to a kind of antiperspirant deodorant composition and its application in male antiperspirant deodorant product.The composition includes the following components: Sophora root extract, Oldenlandia diffusa extract, salvia extract, Hibiscus sabdariffa flower extract and Radix Ophiopogonis extract, the weight ratio of the Sophora root extract, Oldenlandia diffusa extract, salvia extract, Hibiscus sabdariffa flower extract and Radix Ophiopogonis extract is (0.05-2) :(0.01-1) :(0.01-1) :(0.005-2) :(0.01-1).The composition of the present application can achieve the purpose of deodorization from the two aspects of inhibition and bacteriostasis by reasonable collocation of the above ingredients, and specifically regulate the influence of androgen on sweating, more suitable for adding in male antiperspirant deodorant product.

Description

An antiperspirant and deodorant composition and its application in men's antiperspirant and deodorant products Technical Field

[0001] This invention relates to the technical field of men's antiperspirant and deodorant products, specifically to an antiperspirant and deodorant composition and its application in men's antiperspirant and deodorant products. Background Technology

[0002] In daily life, body odor can affect people's self-confidence and quality of life. Studies have shown that people tend to evaluate others more positively when they smell pleasant. Deodorant cosmetics are cosmetics designed to prevent or eliminate unpleasant body odor (mainly referring to armpit odor), and generally consist of antiperspirants, deodorants, bactericides, and fragrances.

[0003] Body odor is an abnormal physiological phenomenon resulting from the interaction of microorganisms and sweat. Human skin contains approximately 2 to 5 million sweat glands, divided into two types: eccrine glands and apocrine glands. Eccrine glands, also known as localized sweat glands or small sweat glands, are distributed throughout the skin, but the number varies significantly in different areas. Apocrine glands, also called large sweat glands, are mainly distributed in areas such as the armpits. Eccrine glands are extensively innervated by blood vessels and nerves, with nerve input primarily from sympathetic cholinergic fibers controlling the regulation of sweat secretion. Regarding apocrine glands, studies have shown that androgen receptors are highly expressed in them, indicating that androgens may promote apocrine gland activity, leading to the secretion of more non-volatile precursor substances. These precursor substances are decomposed by bacteria on the skin surface, forming volatile odorous substances, thus producing body odor. This is also why body odor is stronger in men than in women.

[0004] The axillary flora associated with body odor mainly includes Corynebacterium, Staphylococcus, and anaerobic bacteria. Studies have shown that Corynebacterium is the main cause of body odor.

[0005] Currently, most antiperspirant and deodorant products on the market rely on aluminum salts to stop sweating or add fragrances to mask odors, but their ability to inhibit the odor produced by bacteria decomposing sweat is relatively limited.

[0006] In summary, in addition to considering the antiperspirant and antibacterial effects, men's deodorant products also need to take into account the impact of androgens on underarm odor. Summary of the Invention

[0007] The purpose of this invention is to overcome the shortcomings of the prior art and provide an antiperspirant and deodorant composition and its application in men's antiperspirant and deodorant products.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] In a first aspect, the present invention provides an antiperspirant and deodorant composition comprising the following components: Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract and Ophiopogon japonicus root extract, wherein the weight ratio of Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract and Ophiopogon japonicus root extract is (0.05-2):(0.01-1):(0.01-1):(0.005-2):(0.01-1).

[0010] The effects of the components in the composition are as follows:

[0011] The alkaloids and flavonoids in Sophora flavescens root extract can disrupt bacterial cell membranes and interfere with protein synthesis, exhibiting inhibitory effects on various Gram-positive bacteria, Gram-negative bacteria, and fungi. Furthermore, Sophora flavescens root extract can inhibit 5-α reductase activity and reduce dihydrotestosterone production.

[0012] Some sesquiterpenes and flavonoids in the extract of Hedyotis diffusa can bind to androgen receptors and occupy binding sites. Therefore, it is speculated that this extract may reduce the binding of DHT to androgen receptors, thereby reducing sweat secretion.

[0013] Sage extract contains sage acid, which can inhibit cholinergic receptors in sweat glands, thereby reducing sweat gland secretion.

[0014] Roselle flower extract has a good inhibitory effect on Gram-negative and Gram-positive bacteria. In addition, the organic acids in it can change the alkaline environment of the armpit, which is not conducive to the growth of odor-producing bacteria (especially Corynebacterium).

[0015] The steroidal saponins, polysaccharides, and flavonoids in Ophiopogon japonicus root extract also have certain antibacterial and anti-inflammatory effects, which can alleviate the inflammatory response caused by bacterial overgrowth.

[0016] Preferably, the weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract and Ophiopogon japonicus root extract is (0.1-1):(0.1-0.5):(0.05-0.5):(0.01-0.05):(0.05-0.5).

[0017] More preferably, the weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Roselle flower extract and Ophiopogon japonicus root extract is (0.4-0.6):(0.2-0.4):(0.1-0.3):(0.1-0.3):(0.05-0.15).

[0018] Most preferably, the mass ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract and Ophiopogon japonicus root extract is 0.5:0.3:0.2:0.2:0.1.

[0019] In a second aspect, the present invention provides the use of the antiperspirant and deodorant composition of the first aspect in the preparation of antiperspirant and deodorant products for men.

[0020] Preferably, the men's antiperspirant and deodorant product is a spray, roll-on liquid, gel, or wipe, and the amount of the composition added is 1%-10% of the total weight of the men's antiperspirant and deodorant product.

[0021] Thirdly, the present invention provides a roll-on liquid comprising the following raw materials by weight percentage: 1%-10% of the antiperspirant and deodorant composition described in the first aspect, 4%-14% of a moisturizer, 0.5%-3% of a preservative, 0.01%-0.05% of a thickener and 0.01%-0.3% of a pH adjuster, with the balance being deionized water.

[0022] Preferably, the moisturizer is glycerin and / or sorbitol.

[0023] Preferably, the preservative includes at least one of 1,3-propanediol, 1,2-hexanediol, and p-hydroxyacetophenone.

[0024] Preferably, the thickener is xanthan gum.

[0025] Preferably, the pH adjuster is EDTA-disodium.

[0026] Fourthly, the present invention provides a method for preparing the roll-on liquid of the third aspect, comprising the following steps:

[0027] S1. Add 4-6 times the total mass of deionized water to each component of the antiperspirant and deodorant composition and mix and stir to obtain an antiperspirant and deodorant composition solution.

[0028] S2. Mix the preservative with some deionized water and dissolve it at 55-65℃ to obtain a mixture;

[0029] S3. After the temperature of the mixture in S2 drops to 35-45℃, add the moisturizer, thickener, antiperspirant and deodorant composition solution and the remaining deionized water, stir evenly, and finally add the pH adjuster to obtain the roll-on liquid.

[0030] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0031] The deodorizing and antiperspirant composition of this invention contains Sophora flavescens root extract and Hedyotis diffusa extract, which have a synergistic effect, reducing the promoting effect of androgens on apocrine sweat glands by inhibiting the conversion of testosterone to DHT and the binding of DHT to androgen receptors. Sage extract reduces the secretion of eccrine sweat glands by inhibiting cholinergic receptors. The reasonable combination of the three components can inhibit both types of sweat glands and enhance the antiperspirant effect. The reasonable combination of Sophora flavescens root extract, roselle flower extract and Ophiopogon japonicus root extract can better exert antibacterial effects in terms of broad-spectrum antibacterial, regulating the microbial living environment and anti-inflammation. The reasonable combination of the above components can achieve the purpose of deodorization by inhibiting sweating and inhibiting bacteria, and can specifically regulate the influence of androgens on sweating, making it more suitable for inclusion in men's antiperspirant and deodorant products. Detailed Implementation

[0032] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0033] The sources of the raw materials used in the following examples and comparative examples are as follows:

[0034] Sophora flavescens root extract: manufactured by Xi'an Jinheng Chemical Co., Ltd.;

[0035] Hedyotis diffusa extract: manufactured by Draco Natural Products.

[0036] Sage extract: manufactured by Shaanxi Haolin Biotechnology Co., Ltd.;

[0037] Roselle flower extract: manufactured by Xi'an Feida Biotechnology Co., Ltd.

[0038] Ophiopogon japonicus root extract: manufactured by Dongshengshengkang (Shaanxi) Biotechnology Co., Ltd.

[0039] Unless otherwise specified, all other materials, reagents, etc. used in the examples and comparative examples are commercially available.

[0040] Example 1

[0041] An antiperspirant composition comprising Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.5:0.3:0.2:0.2:0.1. The total mass fraction of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract is 100 parts.

[0042] Example 2

[0043] An antiperspirant composition comprising Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.4:0.2:0.1:0.1:0.05. The total mass fraction of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract is 100 parts.

[0044] Example 3

[0045] An antiperspirant composition comprising Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.6:0.4:0.3:0.3:0.15. The total mass fraction of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract is 100 parts.

[0046] Example 4

[0047] An antiperspirant composition comprising Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.1:0.5:0.05:0.05:0.5. The total mass fraction of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract is 100 parts.

[0048] Example 5

[0049] An antiperspirant composition comprising Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract in a weight ratio of 1:0.1:0.5:0.01:0.05. The total mass fraction of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract is 100 parts.

[0050] Example 6

[0051] An antiperspirant composition comprising Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.05:1:0.01:2:0.01. The total mass fraction of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract is 100 parts.

[0052] Example 7

[0053] An antiperspirant composition comprising Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract in a weight ratio of 2:0.01:1:0.005:1. The total mass fraction of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Roselle flower extract, and Ophiopogon japonicus root extract is 100 parts.

[0054] Comparative Example 1

[0055] The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not add Sophora flavescens root extract, but uses Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract and Ophiopogon japonicus root extract in a weight ratio of 0.3:0.2:0.2:0.1 to make up for the missing amount.

[0056] Comparative Example 2

[0057] The difference between Comparative Example 2 and Example 1 is that Comparative Example 2 does not add Hedyotis diffusa extract, but uses Sophora flavescens root extract, Sage extract, Roselle flower extract and Ophiopogon japonicus root extract in a weight ratio of 0.5:0.2:0.2:0.1 to make up for the missing amount.

[0058] Comparative Example 3

[0059] The difference between Comparative Example 3 and Example 1 is that Comparative Example 3 does not add sage extract, but uses Sophora flavescens root extract, Hedyotis diffusa extract, roselle flower extract and Ophiopogon japonicus root extract in a weight ratio of 0.5:0.2:0.2:0.1 to make up for the missing amount.

[0060] Comparative Example 4

[0061] The difference between Comparative Example 4 and Example 1 is that Comparative Example 4 does not add hibiscus flower extract, but uses Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract and Ophiopogon japonicus root extract in a weight ratio of 0.5:0.3:0.2:0.1 to make up for the missing amount.

[0062] Comparative Example 5

[0063] The difference between Comparative Example 5 and Example 1 is that Comparative Example 5 does not add Ophiopogon japonicus root extract, but uses Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract and Hibiscus rosa-sinensis flower extract in a weight ratio of 0.5:0.3:0.2:0.2 to make up for the missing amount.

[0064] Test Example 1: Antibacterial Zone Test

[0065] 1. Preparation before the experiment

[0066] 1.1 Material Preparation

[0067] Filter paper discs: 6mm diameter circular qualitative filter paper discs (sterilized at 121℃ for 30 minutes, dried, and then sealed for storage).

[0068] Sample solution: Accurately weigh the example / comparative sample, prepare a 1% concentration (w / v) solution with sterile physiological saline, and sterilize with a 0.22 μm filter membrane;

[0069] Culture medium: Nutrient agar medium (sterility needs to be verified; after melting, maintain a water bath at 45-50℃ for later use).

[0070] Bacterial suspension: Fresh cultures of Staphylococcus aureus ATCC 25923 standard strain within the third generation, adjusted to a McFarland turbidity of 0.5 (approximately 1.5 × 10⁻⁶) with 0.9% sterile physiological saline. 8 CFU / mL

[0071] 1.2 Equipment Calibration

[0072] The biosafety cabinet was turned on for UV sterilization 30 minutes in advance, the vernier calipers were calibrated to an accuracy of 0.01 mm, and the temperature of the constant temperature incubator was verified (37±1℃).

[0073] 2. Sample processing

[0074] Inside the biosafety cabinet, use a sterile pipette to add 20 μL of sample solution to a sterile filter paper. After allowing it to stand for 2 minutes to infiltrate, place it flat in a sterile Petri dish (in a single layer to avoid overlapping) and then dry it in a 37°C hot air drying oven until it reaches constant weight.

[0075] 3. Preparation of inoculation culture medium

[0076] Pour 15-18 mL of nutrient agar (4 mm ± 0.5 mm thick) into each dish, let it stand horizontally for 30 minutes to solidify, and label the plate with the plate number and the date of operation.

[0077] 4. Bacterial solution coating

[0078] Dip a sterile cotton swab in the bacterial suspension and spread it evenly on the agar surface in a "Z" shape three times, rotating the plate 60° each time to ensure that the bacterial layer coverage is >95%. Let it dry at room temperature for 5 minutes with the lid off.

[0079] 5. Place the filter paper.

[0080] Place 4 experimental groups + 1 blank control (sterile saline-treated filter paper discs) in a cross shape on each plate, with a spacing of ≥24mm between each disc and a distance of ≥15mm from the edge of the plate. Use sterile forceps to pick up the edge of the discs, gently touch the culture medium, and release them immediately.

[0081] 6. Cultivation and Observation

[0082] Place the above filter paper discs upright in a 37°C incubator and incubate for 17 hours.

[0083] 7. Result Measurement

[0084] After incubation, remove the petri dish and measure the diameter of the inhibition zone (accurate to 0.1 mm) using calipers under natural light or a colony counter. The measurement should be taken perpendicularly to the center of the inhibition zone in two mutually perpendicular directions, and the average value should be recorded as the diameter of the inhibition zone. For the blank control inhibition zone, no inhibition zone should appear. If an inhibition zone appears, it indicates potential contamination during the experiment, and the experiment must be repeated. See Table 1 for details.

[0085] Table 1. Data on the diameter of the inhibition zone for each group of samples.

[0086] The diameter of the inhibition zone of the sample (mm) is as follows: Example 1: 16.7; Example 2: 15.4; Example 3: 16.2; Example 4: 14.7; Example 5: 15.6; Example 6: 13.9; Example 7: 15.0; Comparative Example 1: 5.1; Comparative Example 2: 8.4; Comparative Example 3: 9.6; Comparative Example 4: 6.9; Comparative Example 5: 7.2 surface

[0087] As shown in Table 1, and based on the data from Examples 1, 2-7, and Comparative Examples 1-5, the components that affect the antibacterial properties of the composition from largest to smallest are: Sophora flavescens root extract, Hibiscus rosa-sinensis flower extract, Ophiopogon japonicus root extract, Hedyotis diffusa extract, and Salvia miltiorrhiza extract. Sophora flavescens root extract plays the main antibacterial role, but the combination of Sophora flavescens root extract, Hibiscus rosa-sinensis flower extract, Ophiopogon japonicus root extract, Hedyotis diffusa extract, and Salvia miltiorrhiza extract can synergistically enhance the antibacterial effect.

[0088] Test Example 2: Test on the inhibitory ability of the composition against 5α-reductase

[0089] 1. Reagent preparation

[0090] Sample solution: Accurately weigh an appropriate amount of the example or comparative composition and prepare a 2% aqueous solution using ultrapure water. During the preparation process, use an electronic balance (accuracy 0.0001g) to weigh accurately and stir thoroughly with a magnetic stirrer until completely dissolved. After the solution is prepared, store it in a refrigerator at 4°C for later use.

[0091] PBS solution: According to the PBS buffer formula, accurately weigh the reagents such as sodium chloride, potassium chloride, disodium hydrogen phosphate, and potassium dihydrogen phosphate, dissolve them in ultrapure water and make up to volume, adjust the pH to 7.3, and then autoclave (121℃, 20 minutes) for later use.

[0092] NADPH solution: Prepare a 2 mM solution using PBS solution at pH 7.3;

[0093] Testosterone solution: A 0.83 nM solution prepared from a 75% ethanol solution;

[0094] Positive control solution: Weigh finasteride and prepare a 2.5 mmol / L solution using a suitable solvent.

[0095] 2. Enzyme solution preparation

[0096] Remove the 5α-reductase lyophilized powder from the -80℃ freezer and dissolve and dilute it using the specific buffer solution as instructed in the product manual to prepare the enzyme solution of the required concentration for the experiment. Store the prepared enzyme solution in an ice bath to avoid prolonged exposure to room temperature, which could lead to a decrease in enzyme activity.

[0097] 3. Instrument Preparation

[0098] Preheat the microplate reader for at least 30 minutes to ensure it reaches a stable operating state. Simultaneously check the temperature accuracy of the 37℃ incubator; calibration can be performed using a standard thermometer, with an error range controlled within ±0.5℃. Prepare test tubes, pipettes (equipped with 100μL and 1mL tips, all sterilized), and 96-well microplates (sterile and transparent), among other experimental consumables.

[0099] 4. Sample tube handling

[0100] Add 1 mL of each example and comparative sample solution, 1 mL of enzyme solution, 1 mL of NADPH solution, and 1 mL of testosterone solution to a test tube, and gently shake to obtain a mixed liquid. Use a pipette to transfer 200 μL of the mixed liquid to a 96-well microplate. Perform three replicates for each sample. Measure the absorbance at 340 nm using a microplate reader; this is the first measurement value, A. 样品0 After incubating the sample at 37°C for 20 minutes, it was placed in an ELISA reader for detection. The absorbance was measured at 340 nm, which is the second measurement value A. 样品20 .

[0101] 5. Enzyme tube operation

[0102] Add 1 mL of PBS solution, 1 mL of enzyme solution, 1 mL of NADPH solution, and 1 mL of testosterone solution to a test tube, and gently mix to obtain a mixed liquid. Use a pipette to transfer 200 μL of the mixed liquid into a 96-well microplate. Perform three replicates for each sample. Measure the absorbance at 340 nm using a microplate reader; this is the first measurement value (A). 酶0 After incubating the sample at 37°C for 20 minutes, it was placed in an ELISA reader for detection. The absorbance was measured at 340 nm, which is the second measurement value A. 酶20Simultaneously, blank and positive control tests were performed. The blank control group consisted of replacing the sample solution in the sample tube with an equal volume of deionized water, and the positive control group consisted of 1 mL of finasteride solution with a concentration of 2.5 mmol / L. The procedure was the same as above.

[0103] 6. Inhibition rate calculation

[0104] The formula for calculating the inhibition rate is: The data for each group are shown in Table 2.

[0105] Table 2. 5-α reductase inhibition rate data for each group of samples.

[0106] 5-α reductase inhibition rate (%) Example 1: 54.5 Example 2: 50.6 Example 3: 53.7 Example 4: 42.2 Example 5: 47.4 Example 6: 40.4 Example 7: 45.4 Comparative Example 1: 15.0 Comparative Example 2: 16.2 Comparative Example 3: 17.9 Comparative Example 4: 21.7 Comparative Example 5: 22.5 Positive Control Group: 71.5 surface

[0107] As shown in Table 2, 5-α reductase is an enzyme that promotes the conversion of testosterone to dihydrotestosterone (DHT), and DHT is closely related to the overactivity of sebaceous glands. A higher 5-α reductase inhibition rate indicates a better performance of the sample in inhibiting androgens.

[0108] Based on the data from Example 1 and Comparative Examples 1-5, it can be seen that the components affecting androgen conversion in the composition, from largest to smallest, are Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract, and Ophiopogon japonicus root extract. However, the combination of Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract, and Ophiopogon japonicus root extract can synergistically inhibit androgen conversion and prevent it from stimulating sweat glands.

[0109] Based on the data from Examples 1 and 2-7, it can be seen that when the weight ratio of Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract and Ophiopogon japonicus root extract is (0.4-0.6):(0.2-0.4):(0.1-0.3):(0.1-0.3):(0.05-0.15), the 5-α reductase inhibition rate is at a relatively good level.

[0110] Application Example 1-7 and Comparative Application Example 1-5

[0111] The compositions of Examples 1-7 and Comparative Examples 1-5 were added to the roll-on liquid at a concentration of 5 wt% to obtain the roll-on liquids of Application Examples 1-7 and Comparative Application Examples 1-5. The formulations are shown in Table 3.

[0112] The preparation methods of the roll-on liquids in Application Examples 1-7 and Comparative Application Examples 1-5 include the following steps:

[0113] The preparation method of the roll-on liquid includes the following steps:

[0114] S1. Add 5 times the total mass of deionized water to each component of the antiperspirant and deodorant composition and mix and stir to obtain an antiperspirant and deodorant composition solution.

[0115] S2. Mix the preservative with half the amount of deionized water and dissolve it at 60°C to obtain a mixture;

[0116] S3. After the temperature drops to 40℃, add the moisturizer, thickener, antiperspirant and deodorant composition solution and the remaining deionized water, stir well, and finally add the pH adjuster to obtain the roll-on liquid.

[0117] Table 3 Rollerball Liquid Formulations for Application Examples 1-7 and Comparative Application Examples 1-5

[0118]

[0119] Comparative Application Example 6

[0120] In contrast, the roll-on liquid in Application Example 6 does not contain the antiperspirant and deodorant composition, but uses an equal amount of deionized water instead of the composition, and the preparation method is the same as in Application Example 1.

[0121] Test Example 3: Roll-on liquid test under the armpit

[0122] 1. Selection criteria:

[0123] (1) Males aged 18-45 years with a bromhidrosis level of 1 or above (based on the bromhidrosis grading method of the "Expert Consensus on Botox Injection Treatment of Hyperhidrosis and Axillary Odor").

[0124] (2) No history of axillary surgery and no use of other antiperspirant / antibacterial products for more than 7 days;

[0125] (3) No axillary skin damage, allergic diseases or systemic diseases (such as diabetes, liver and kidney dysfunction).

[0126] Sixty-five men who met the above criteria were randomly divided into 13 groups of five each.

[0127] 2. Grouping and Sample Size

[0128] Experimental group: using the roll-on liquids of Application Examples 1-7 and Control Application Examples 1-6;

[0129] Blank group: The subjects did not use any product under their right armpit as a blank control group;

[0130] 3. Deodorization effect test steps

[0131] The odor intensity rating (Wild II method) was used, and five trained odor evaluators independently rated the odors in a blind evaluation. The rating criteria are shown in Table 4.

[0132] Table 4 Wild Level II Scoring Criteria

[0133] The odor rating system is as follows: 0. No odor; 1. Threshold odor; 2. Very faint odor; 3. Faint odor; 4. Faint to moderate odor; 5. Moderate odor; 6. Slightly strong odor; 7. Moderately strong odor; 8. Strong odor; 9. Very strong odor; 10. Extremely strong odor. surface

[0134] Baseline score: On day 0 (before first use), volunteers lay with their arms outstretched, and olfactory assessors evaluated the odor in both armpits sequentially and recorded the average score (S). 前 ).

[0135] Final assessment: After sweat collection on day 14 of the test, the left axillary odor (S) was reassessed by the same group of olfactory evaluators. 后 The right axilla was used as a baseline control.

[0136] Deodorization rate calculation: Deodorization rate (%) = (S 后 -S 前 ) / S 前 ×100%; see Table 5 for specific data.

[0137] 4. Steps for testing antiperspirant effect

[0138] Preliminary preparations

[0139] Specialized gasket treatment: Sterile cotton fiber gaskets (5cm×5cm) are used. Each gasket is weighed using an electronic balance (accuracy 0.001g) and its initial mass is recorded (denoted as m). 前左 m 前右 Seal and individually package for sterilization and use.

[0140] Product usage instructions: Apply 0.3g of sample evenly to the left armpit (right armpit blank control) once in the morning and once in the evening for 14 consecutive days; during use, do not use other antiperspirant / deodorant products, and avoid spicy food and strenuous exercise.

[0141] Test Day Process

[0142] Cleaning and pretreatment: On the morning of the 15th day, wash both armpits with unscented neutral body wash (such as Cetaphil), rinse with warm water and dry with cool air; apply the sample to the left armpit once, and do not treat the right armpit.

[0143] Pad installation and sweat collection: Apply the pre-weighed pad to the armpit and secure it with breathable tape to ensure complete coverage of the sweat gland area; enter the constant temperature room (temperature 38℃±1℃, humidity 35%±5% RH) and sit quietly for 60 minutes (avoid large-scale limb movements).

[0144] Quantitative analysis of sweat:

[0145] Weigh immediately after removing the gasket (recorded as m) 后左 m 后右 );

[0146] The formula for testing antiperspirant effectiveness is: Specific data are shown in Table 5.

[0147] Table 5. Deodorization and antiperspirant rates of each sample group.

[0148] Sample Antiperspirant Rate / % Deodorant Rate / % Application Example 1 52.7 48.1 Application Example 2 47.6 44.1 Application Example 3 49.8 45.7 Application Example 4 43.2 40.2 Application Example 5 45.2 43.4 Application Example 6 42.8 38.5 Application Example 7 44.6 41.0 Comparison Application Example 1 21.2 18.1 Comparison Application Example 2 22.5 21.3 Comparison Application Example 3 23.7 22.0 Comparison Application Example 4 28.6 23.3 Comparison Application Example 5 31.2 24.6 Comparison Application Example 6 3.4 1.8 surface

[0149] As shown in Table 5, the main deodorizing and antiperspirant components of the roll-on liquid of the present invention are Sophora flavescens root extract, Hedyotis diffusa extract, Roselle flower extract, Ophiopogon japonicus root extract, and Sage extract. These five components work synergistically to reduce the secretion of eccrine and apocrine sweat glands to achieve the purpose of antiperspirant. They also reduce the growth of axillary flora by inhibiting bacteria and changing the bacterial growth environment. The combination of antiperspirant and antibacterial effects achieves the purpose of deodorization. At the same time, because this composition can effectively inhibit androgens, it is more suitable for men.

[0150] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A composition for preventing sweating and deodorizing, characterized in that, It is composed of the following components: Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract and Ophiopogon japonicus root extract, wherein the weight ratio of Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Hibiscus rosa-sinensis flower extract and Ophiopogon japonicus root extract is (0.05-2):(0.01-1):(0.01-1):(0.005-2):(0.01-1).

2. The antiperspirant and deodorant composition as described in claim 1, characterized in that, The weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Roselle flower extract and Ophiopogon japonicus root extract is (0.1-1):(0.1-0.5):(0.05-0.5):(0.01-0.05):(0.05-0.5).

3. The antiperspirant and deodorant composition as described in claim 1, characterized in that, The weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Salvia miltiorrhiza extract, Roselle flower extract and Ophiopogon japonicus root extract is (0.4-0.6):(0.2-0.4):(0.1-0.3):(0.1-0.3):(0.05-0.15).

4. The use of any one of the antiperspirant and deodorant compositions according to claims 1-3 in the preparation of men's antiperspirant and deodorant products.

5. The application of the antiperspirant and deodorant composition as described in claim 4 in the preparation of men's antiperspirant and deodorant products, characterized in that, The men's antiperspirant and deodorant product is a spray, roll-on liquid, gel, or wipe, and the amount of the composition added is 1%-10% of the total weight of the men's antiperspirant and deodorant product.

6. A roll-on liquid, characterized in that, The ingredients comprise the following ingredients by weight percentage: 1%-10% of the antiperspirant and deodorant composition according to any one of claims 1-3, 4%-14% of humectant, 0.5%-3% of preservative, 0.01%-0.05% of thickener and 0.01%-0.3% of pH adjuster, with the balance being deionized water.

7. The roll-on liquid as described in claim 6, characterized in that, The raw materials are selected from at least one of (a)-(d): (a) the humectant is glycerin and / or sorbitol; (b) the preservative includes at least one of 1,3-propanediol, 1,2-hexanediol and p-hydroxyacetophenone; (c) the thickener is xanthan gum; and (d) the pH adjuster is disodium EDTA.

8. The method for preparing the roll-on liquid according to claim 7, characterized in that, Includes the following steps: S1. Add 4-6 times the total mass of deionized water to each component of the antiperspirant and deodorant composition and mix and stir to obtain an antiperspirant and deodorant composition solution; S2. Mix the preservative and part of the deionized water and dissolve at 55-65℃ to obtain a mixture; S3. After the temperature of the mixture in S2 drops to 35-45℃, add the moisturizer, thickener, antiperspirant and deodorant composition solution and the remaining deionized water, stir evenly, and finally add the pH adjuster to obtain the roll-on liquid.

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