Traditional Chinese medicine compound with function of removing stasis, pharmaceutical preparation and preparation method of traditional Chinese medicine compound

Abstract

The invention relates to the field of traditional Chinese medicine clinic, and particularly provides a traditional Chinese medicine compound with a stasis removing function, a pharmaceutical preparation and a preparation method thereof, and the traditional Chinese medicine compound with the stasis removing function comprises at least two of radix astragali, raw oyster and radix scutellariae. Compared with the prior art, the astragalus mongholicus in the traditional Chinese medicine compound with the function of removing stasis, provided by the invention, can resist inflammation, relieve swelling and promote cell growth and tissue repair; the raw oysters can soften hard lumps, dissipate stagnation, astringe and induce astringency, so that the hard lumps are softened, and local swelling and pain are relieved; the radix scutellariae has anti-inflammatory and antibacterial effects and can relieve swelling and pain and relieve inflammatory response of intramuscular injection parts; at least one of radix astragali and radix scutellariae is matched with raw oyster, so that the traditional Chinese medicine composition can be effectively used for relieving local induration caused by intramuscular injection of progesterone, and has the effects of relieving redness, swelling and pain accompanied by induration.

Description

Technical Field

[0001] The present application relates to the clinical field of traditional Chinese medicine, specifically to a traditional Chinese medicine compound with a knot-dispersing function, a pharmaceutical preparation for treating local muscle nodules, and a preparation method of a pharmaceutical preparation for treating local muscle nodules. Background Art

[0002] With changes in the environment and lifestyle in modern society, the incidence of threatened abortion is on the rise. In particular, with the gradual increase in the incidence of infertility and the popularization of assisted reproductive technology (ART), the number of patients who successfully conceive through assisted reproductive technology has increased year by year. These patients are usually accompanied by problems such as luteal insufficiency and insufficient support for early embryonic development, and require long-term use of progestins for pregnancy preservation. Oral progestins need to be absorbed through the gastrointestinal tract to produce a first-pass effect. Often, when oral progestins cannot achieve the desired therapeutic effect, intramuscular progesterone injection can achieve better clinical effects.

[0003] However, intramuscular injection of progesterone often causes patients to experience intense discomfort due to local injection reactions, which seriously affects treatment compliance. Some patients even discontinue treatment due to this, increasing the risk of threatened abortion. This problem not only affects the continuity and effectiveness of patients' treatment, but also has a negative impact on their psychological state and increases the complexity of communication between doctors and patients. As an oily injection, progesterone injection, due to its large molecular weight and poor absorption properties, often causes local tissue damage during long-term and repeated intramuscular injections, resulting in adverse reactions such as swelling, pain, and nodules, and even complications such as secondary infection and abscesses.

[0004] Currently, clinical treatments for issues caused by intramuscular progesterone injections typically involve local physical therapy or medication-assisted therapies. Local physical therapy, such as heat compresses and massage, can promote local blood circulation and accelerate drug absorption, but the effects are limited. Medication-assisted therapies, such as magnesium sulfate compresses, can only alleviate milder symptoms like local swelling but have little effect on established nodules. Furthermore, medication-assisted therapies are cumbersome to administer. Summary of the Invention

[0005] This application mainly provides a traditional Chinese medicine compound with a knot-dispersing function, a pharmaceutical preparation for treating local muscle knots, and a preparation method of a pharmaceutical preparation for treating local muscle knots, which can effectively relieve the knots caused by intramuscular injection of progesterone.

[0006] In order to solve the above technical problems, a technical solution adopted in this application is: to provide a traditional Chinese medicine compound with the function of dispersing nodules, including at least two of raw oysters, scutellaria baicalensis, and astragalus.

[0007] In a specific embodiment, the traditional Chinese medicine compound with the function of dispersing nodules includes astragalus, raw oyster and scutellaria.

[0008] In a specific embodiment, the Chinese herbal compound with the function of dispersing nodules comprises 6 to 4 parts of astragalus, 6 to 4 parts of raw oyster and 1 to 2 parts of scutellaria in terms of mass ratio.

[0009] In a specific embodiment, the mass ratio of astragalus, raw oyster and scutellaria is 4:4:1.

[0010] In order to solve the above technical problems, another technical solution adopted in this application is: to provide a pharmaceutical preparation for treating local muscle nodules, wherein the pharmaceutical preparation for treating local muscle nodules comprises the Chinese herbal compound with the function of dispersing nodules described in any one of the above specific embodiments and optional pharmaceutically acceptable excipients.

[0011] In a specific embodiment, the pharmaceutical preparation for treating local muscle induration comprises an external ointment.

[0012] In order to solve the above technical problems, another technical solution adopted in the present application is: to provide a pharmaceutical preparation for treating local muscle nodules as described in any one of the above specific embodiments for use in alleviating the nodules caused by intramuscular injection of progesterone.

[0013] In order to solve the above technical problems, another technical solution adopted in this application is: to provide a method for preparing a pharmaceutical preparation for treating local muscle nodules, comprising mixing and grinding at least one of astragalus and scutellaria with raw oysters to prepare a pharmaceutical powder; mixing the pharmaceutical powder with a plaster base to prepare the pharmaceutical preparation for treating local muscle nodules.

[0014] In one embodiment, the plaster base comprises petrolatum.

[0015] In one specific embodiment, the mass ratio of the drug powder to vaseline is 1:(1-2).

[0016] The present application has the beneficial effects as follows: different from the situation of the prior art, the present application embodiment provides a Chinese medicine compound with a stagnation-dispersing function, a pharmaceutical preparation for treating local muscle induration and a preparation method for treating local muscle induration, and the Chinese medicine compound with a stagnation-dispersing function includes at least two of raw oyster, radix scutellariae, and astragalus. Wherein, raw oyster has the effect of softening and dispersing hard masses, astringing and consolidating, can be used to soften the induration caused by intramuscular injection of progesterone, and helps to reduce tissue fluid oozing and swelling, thus can alleviate the local swelling and pain caused by induration. Astragalus has diuretic and detumescence, supports toxins and discharges pus, and has the effect of promoting granulation, can alleviate the edema accompanied by induration, and can suppress the process of induration formation, and promote cell growth, tissue repair, thus by enhancing the body's immune function and anti-inflammatory effect, helps to alleviate inflammation and the local swelling and pain caused by intramuscular injection of progesterone. The ingredients contained in Scutellaria baicalensis, such as baicalin and baicalein, can inhibit the release of inflammatory mediators and have significant anti-inflammatory and antibacterial effects. They can effectively reduce the local inflammatory response caused by intramuscular injection of progesterone and relieve the redness, swelling and pain in the nodule area.

[0017] Compared with the existing technology, by combining at least one of Astragalus and Scutellaria with raw oyster, the anti-inflammatory effect of at least one of Astragalus and Scutellaria and the knot-dispersing effect of raw oyster can be effectively utilized, so that the traditional Chinese medicine compound with knot-dispersing function provided by the present application can be effectively used to soften and dispel local nodules caused by intramuscular injection of progesterone, and has the effect of reducing inflammation, swelling and pain associated with the nodules. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0019] Figure 1 This is a schematic flow chart of an embodiment of a method for preparing a pharmaceutical preparation for treating local muscle induration according to the present application. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application are described clearly and in detail below. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of the embodiments. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present application. The terms used in the specification of the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application.

[0021] The embodiments of the present invention will be described in detail below with reference to the examples, but those skilled in the art will appreciate that the following examples are intended only to illustrate the present invention and should not be construed as limiting the scope of the invention. Where specific conditions are not specified in the examples, the methods were performed according to conventional conditions or the conditions recommended by the manufacturer. Where the manufacturers of the reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0022] Reference herein to an "embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it refer to independent or alternative embodiments that are mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0023] With changes in the environment and lifestyle in modern society, the incidence of threatened abortion is on the rise. In particular, with the gradual increase in the incidence of infertility and the popularization of assisted reproductive technology (ART), the number of patients who successfully conceive through assisted reproductive technology has increased year by year. These patients are usually accompanied by problems such as luteal insufficiency and insufficient support for early embryonic development, and require long-term use of progestins for pregnancy preservation. Oral progestins need to be absorbed through the gastrointestinal tract to produce a first-pass effect. Often, when oral progestins cannot achieve the desired therapeutic effect, intramuscular progesterone injection can achieve better clinical effects.

[0024] However, intramuscular injection of progesterone often causes patients to experience intense discomfort due to local injection reactions, which seriously affects treatment compliance. Some patients even discontinue treatment due to this, increasing the risk of threatened abortion. This problem not only affects the continuity and effectiveness of patients' treatment, but also has a negative impact on their psychological state and increases the complexity of communication between doctors and patients. As an oily injection, progesterone injection, due to its large molecular weight and poor absorption properties, often causes local tissue damage during long-term and repeated intramuscular injections, resulting in adverse reactions such as swelling, pain, and nodules, and even complications such as secondary infection and abscesses.

[0025] Currently, clinical treatments for issues caused by intramuscular progesterone injections typically involve local physical therapy or medication-assisted therapies. Local physical therapy, such as hot compresses, massage, and potato chip applications, can promote local blood circulation and accelerate drug absorption, but the effects are limited and unsuitable for some patients. Medication-assisted therapies, such as magnesium sulfate compresses, can only alleviate milder symptoms like local swelling but have little effect on established nodules. Furthermore, medication-assisted therapies are cumbersome to administer.

[0026] In Traditional Chinese Medicine (TCM), the "Sanjie San" (Sanjie San) method offers significant advantages in treating localized inflammation and promoting the dissipation of blood stasis. As a classic TCM formula for softening and dispersing nodules, promoting blood circulation and removing blood stasis, and relieving swelling and pain, it is widely used in external treatments. In TCM clinical practice, this method is primarily used to treat various nodule and mass conditions, such as thyroid nodules, breast hyperplasia, breast tumors, gynecological conditions, and skin diseases.

[0027] Traditional Chinese medicine (TCM) has demonstrated significant efficacy in the treatment of thyroid nodules. Combining topical and oral administration, it can effectively reduce nodule size and improve clinical symptoms such as chest tightness and poor appetite. Breast hyperplasia, a condition considered a breast disease in Traditional Chinese Medicine, is effectively alleviated and reduced by TCM through mechanisms such as soothing the liver and regulating qi, resolving phlegm and dispersing nodules, and promoting blood circulation and removing blood stasis.

[0028] In gynecology, traditional Chinese medicine (TCM)-based methods for dispersing nodules are widely used to treat conditions such as uterine fibroids and ovarian cysts. These methods primarily reduce the size of tumors by softening and dispersing nodules and promoting blood circulation and removing blood stasis. Studies have shown that TCM-based methods for dispersing nodules are significantly effective in improving symptoms, reducing tumor size, and alleviating the side effects of Western medication, particularly in adult women. In dermatology, TCM-based methods for dispersing nodules are widely used to treat cystic acne. Using a self-prepared dispersing decoction combined with topical application of Jinhuang San can effectively reduce cysts and alleviate related symptoms.

[0029] However, in the field of reproductive medicine, traditional Chinese medicine-based nodule-dispersing methods have not been well applied. To improve or resolve the above technical problems, the inventors of this application have explored the use of traditional Chinese medicine-based nodule-dispersing methods in treating localized nodules after intramuscular injection of progesterone. After long-term research, they have proposed at least the following embodiments.

[0030] The specific embodiment of the present application provides a traditional Chinese medicine compound with the function of dispersing nodules, including at least two of raw oyster, scutellaria baicalensis, and astragalus.

[0031] Among them, Astragalus is slightly warm in nature and sweet in taste. It belongs to the lung meridian and spleen meridian. It has the effects of replenishing qi and strengthening the exterior, promoting diuresis and reducing swelling, expelling toxins and draining pus, and promoting tissue regeneration. It can relieve edema associated with nodules, and promote cell growth and tissue repair. It helps to reduce inflammation and local swelling and pain caused by intramuscular injection of progesterone by enhancing the body's immune function and anti-inflammatory effects.

[0032] Specifically, astragalus polysaccharides, astragalus saponins and other ingredients contained in astragalus can regulate the human immune system and reduce the inflammatory response caused by intramuscular injection of progesterone by inhibiting proinflammatory factors such as TNF-α (tumor necrosis factor α) and IL-6 (interleukin 6).

[0033] The flavonoids in Astragalus membranaceus can dilate blood vessels, improve blood circulation, and act as a diuretic, thereby accelerating the absorption of intramuscularly injected progesterone and reducing local drug accumulation, effectively alleviating induration. Flavonoids also have antioxidant properties, scavenging free radicals, reducing oxidative damage to tissues, inhibiting fibrosis, and promoting the repair of damaged muscles at the injection site.

[0034] Scutellaria baicalensis is bitter and cold in nature, and enters the lung, gallbladder, spleen, stomach, large intestine, and small intestine meridians. The baicalin and baicalein contained in it can inhibit the NF-κB (nuclear factor kappa-B) signaling pathway, reduce the levels of inflammatory factors such as TNF-α (tumor necrosis factor α) and IL-6, and alleviate the local redness, swelling, and pain caused by intramuscular injection of progesterone.

[0035] At the same time, baicalin can reduce oxidative stress damage, protect local tissues from free radical damage, and reduce fibroblast proliferation and collagen synthesis by regulating the TGF-β (transforming growth factor-β) / Smad (a protein that plays a core role in the TGF-β signaling pathway) pathway, so that baicalin can delay the process of nodule fibrosis and play a role in preventing nodule formation after intramuscular injection of progesterone.

[0036] Raw oysters are salty and slightly cold in nature, entering the liver, gallbladder, and kidney meridians. They have the properties of softening and dispersing lumps, as well as astringing and consolidating. They can help improve induration caused by intramuscular progesterone injection by regulating local metabolism and inhibiting fibrosis. The elements and amino acids they contain can regulate fibroblast activity, reduce excessive collagen synthesis, and slow the progression of induration, thereby preventing the formation of induration after intramuscular progesterone injection.

[0037] The taurine, zinc and other ingredients contained in raw oysters have certain anti-inflammatory and antioxidant effects, which can reduce local oxidative stress damage, and by regulating pathways such as NF-κB, reduce the levels of pro-inflammatory factors such as IL-6 and TNF-α, thereby reducing the inflammation associated with nodules.

[0038] Different from the situation of the prior art, the present application embodiment provides a Chinese medicine compound with a stagnation-dispersing function, a pharmaceutical preparation for treating local muscle induration, and a preparation method for treating local muscle induration, and the Chinese medicine compound with a stagnation-dispersing function includes at least two of Radix Astragali, Radix Scutellariae, and Concha Ostreae. Wherein, Concha Ostreae has the effects of softening and dispersing stagnation, astringing and consolidating, can be used to soften the induration caused by intramuscular injection of progesterone, and helps to reduce tissue fluid exudation and swelling, thereby can alleviate the local swelling and pain caused by induration. Radix Astragali has diuretic and detumescence, supports toxins and discharges pus, and has the effect of promoting granulation, can alleviate the edema accompanied by induration, and can promote cell growth, tissue repair, thereby by enhancing the body's immune function and anti-inflammatory effect, helps to alleviate the inflammation and local swelling and pain caused by intramuscular injection of progesterone. The ingredients contained in Scutellaria baicalensis, such as baicalin and baicalein, can inhibit the release of inflammatory mediators and have significant anti-inflammatory and antibacterial effects. They can effectively reduce the local inflammatory response caused by intramuscular injection of progesterone and relieve the redness, swelling and pain in the nodule area.

[0039] Compared with the existing technology, by combining at least two of astragalus, scutellaria and raw oyster, the anti-inflammatory effect of at least one of astragalus and scutellaria and the nodule-dispersing effect of at least one of raw oyster and scutellaria can be effectively utilized, so that the traditional Chinese medicine compound with nodule-dispersing function provided by the present application can be effectively used to prevent, soften and dispel local nodules caused by intramuscular injection of progesterone, and has the effect of reducing inflammation, swelling and pain associated with the nodules.

[0040] It should be noted that the drugs used in the traditional Chinese medicine compound with the function of dispersing knots provided in this application do not violate the "Eighteen Antidotes" and "Nineteen Fears" of traditional Chinese medicine compatibility. These drugs do not have the possibility of conflict, thus ensuring the safety and effectiveness of the medication.

[0041] In a specific embodiment of the present application, a traditional Chinese medicine compound with a knot-dispersing function includes astragalus, raw oyster, and scutellaria. Furthermore, the traditional Chinese medicine compound with a knot-dispersing function can include three ingredients: astragalus, raw oyster, and scutellaria. This can effectively utilize the anti-inflammatory effects of astragalus and scutellaria, as well as the knot-dispersing effects of raw oyster and scutellaria. This allows the traditional Chinese medicine compound with a knot-dispersing function provided in this application to be effectively used to prevent, soften, and dispel localized induration caused by intramuscular progesterone injection, and has the efficacy of alleviating the inflammation, swelling, and pain associated with the induration.

[0042] In one embodiment of the present application, the herbal compound with a knot-dispersing function comprises, by weight, 6-4 parts of Astragalus, 6-4 parts of Raw Oyster, and 1-2 parts of Scutellaria. The herbal compound with a knot-dispersing function configured according to the weight ratios provided in this embodiment balances the efficacy of the three ingredients, enabling it to be effectively used to prevent, soften, and dissipate localized induration caused by intramuscular progesterone injection, while also alleviating the inflammation, swelling, and pain associated with the induration.

[0043] In a specific embodiment of the present application, preferably, the mass ratio of astragalus, raw oyster and scutellaria is 4:4:1.

[0044] Specifically, in clinical use, considering the size of the affected area produced during the intramuscular injection of progesterone, 120mg-80mg of astragalus, 120mg-80mg of raw oyster, and 20mg-40mg of scutellaria can be prepared into a single dose for use.

[0045] Preferably, in a single dose, the mass of Astragalus membranaceus, the mass of raw oyster, and the mass of Scutellaria baicalensis can be 80 mg, 80 mg, and 20 mg respectively.

[0046] The specific embodiments of the present application also provide a pharmaceutical preparation for treating local muscle induration. The pharmaceutical preparation for treating local muscle induration may include any one of the Chinese herbal compound with the function of dispersing nodules described in the above specific embodiments and optional pharmaceutically acceptable excipients.

[0047] The raw oyster in this pharmaceutical preparation has the effects of softening and dispersing nodules, astringing and consolidating, and can be used to soften the induration caused by intramuscular injection of progesterone, and helps reduce tissue fluid exudation and swelling, thereby alleviating the local swelling and pain caused by the induration. Astragalus has the effects of diuresis and swelling reduction, detoxification and pus removal, and has the effect of promoting tissue regeneration, which can relieve the edema associated with induration, and can promote cell growth and tissue repair, thereby helping to alleviate the inflammation and local swelling and pain caused by intramuscular injection of progesterone by enhancing the body's immune function and anti-inflammatory effects. The ingredients such as baicalin and baicalein contained in Scutellaria baicalensis can inhibit the release of inflammatory mediators, have significant anti-inflammatory and antibacterial effects, and can effectively reduce the local inflammatory reaction caused by intramuscular injection of progesterone, relieving the redness, swelling and pain at the site of the induration.

[0048] Compared with the existing technology, by combining at least one of Astragalus and Scutellaria with raw oysters and configuring them with pharmaceutically acceptable excipients, a pharmaceutical preparation is obtained that can effectively utilize the anti-inflammatory effect of at least one of Astragalus and Scutellaria and the knot-dispersing effect of raw oysters, so that the pharmaceutical preparation for treating local muscle nodules provided by the present application can be effectively used to soften and dispel local nodules caused by intramuscular injection of progesterone, and has the effect of reducing inflammation, swelling and pain associated with the nodules.

[0049] In the present application, a specific embodiment, the pharmaceutical preparation for treating local induration of muscle can include an external ointment. Due to the intramuscular injection of progesterone in the tissue of the human body surface, the adverse reactions such as the induration, inflammation formed are also mostly present in the tissues close to the human body surface such as skin and superficial muscles. Therefore, compared to the oral administration method that needs to bring the drug ingredients to the affected part through blood circulation, the drug ingredients in raw oyster, astragalus, and scutellaria can be absorbed by the patient's skin during the application of the external ointment, so as to be able to act more directly on the position where adverse reactions occur, the pertinence of the pharmaceutical preparation for treating local induration of muscle can be improved, and the adverse reactions caused by intramuscular injection of progesterone can be alleviated faster and more efficiently.

[0050] Referring to the background art, it can be found that although traditional Chinese medicine dispersing knot method is a classic treatment method, it has not been well applied in the field of reproductive medicine. The specific embodiments of this application also provide a pharmaceutical preparation for treating local muscle induration as described in any of the above specific embodiments for alleviating induration caused by intramuscular injection of progesterone. This can improve on the existing traditional Chinese medicine dispersing knot method, explore the use of traditional Chinese medicine dispersing knot method in treating local induration after intramuscular injection of progesterone, and provide a more effective method for the adverse reactions caused by intramuscular injection of progesterone.

[0051] Figure 1 This is a schematic flow chart of an embodiment of the method for preparing a pharmaceutical preparation for treating local muscle induration. It should be noted that if there is substantially the same result, this embodiment is not based on Figure 1 The process sequence shown is limited. Figure 1 As shown, the specific embodiment of the present application also provides a method for preparing a pharmaceutical preparation for treating local muscle induration, and the method for preparing a pharmaceutical preparation for treating local muscle induration comprises:

[0052] S100: mixing and grinding at least one of astragalus and scutellaria with raw oyster to prepare a medicinal powder.

[0053] The astragalus and / or scutellaria in the traditional Chinese medicine compound with the function of dispersing nodules provided in the present application are mixed with raw oysters, and ground into a medicinal powder, so that it can be evenly mixed with other pharmaceutically acceptable excipients to prepare a medicinal preparation for treating local muscle nodules.

[0054] S200: Mixing the drug powder with the plaster base to prepare a drug preparation for treating local muscle induration.

[0055] The drug powder is mixed with a plaster base, thereby preparing a drug preparation for treating local muscle induration.

[0056] The raw oyster in this pharmaceutical preparation has the effects of softening and dispersing nodules, astringing and consolidating, and can be used to soften the induration caused by intramuscular injection of progesterone, and helps reduce tissue fluid exudation and swelling, thereby alleviating the local swelling and pain caused by the induration. Astragalus has the effects of diuresis and swelling reduction, detoxification and pus removal, and has the effect of promoting tissue regeneration, which can relieve the edema associated with induration, and can promote cell growth and tissue repair, thereby helping to alleviate the inflammation and local swelling and pain caused by intramuscular injection of progesterone by enhancing the body's immune function and anti-inflammatory effects. The ingredients such as baicalin and baicalein contained in Scutellaria baicalensis can inhibit the release of inflammatory mediators, have significant anti-inflammatory and antibacterial effects, and can effectively reduce the local inflammatory reaction caused by intramuscular injection of progesterone, relieving the redness, swelling and pain at the site of the induration.

[0057] Compared with the existing technology, by combining at least one of astragalus and scutellaria with raw oyster and making it into powder and mixing it with the plaster base, a pharmaceutical preparation can be prepared that can effectively utilize the anti-inflammatory effect of at least one of astragalus and scutellaria and the knot-dispersing effect of raw oyster, so that the pharmaceutical preparation for treating local muscle nodules provided by the application can be effectively used to soften and dispel local nodules caused by intramuscular injection of progesterone, and has the effect of reducing inflammation, swelling and pain associated with the nodules.

[0058] In one embodiment of the present application, the plaster base may include vaseline. Vaseline is stable and does not react with the medicinal ingredients contained in any of Astragalus, Scutellaria, and Raw Oyster, thus maintaining the stability and effectiveness of the drug preparation for treating local muscle induration.

[0059] When a drug preparation is applied to an affected area of ​​the skin, the microorganisms that grow in it remain in contact with the affected area during use, making it more susceptible to inflammation. Vaseline, however, does not contain water and is less susceptible to microbial growth. Therefore, it can improve the storage stability of drug preparations used to treat localized muscle abscesses, extending their shelf life while maintaining their safety.

[0060] In addition, vaseline has a soft texture, good ductility, non-toxicity, low sensitization, and can maintain a moist environment on the skin, promote hydration of the stratum corneum, and thus enhance drug penetration. When used in conjunction with the traditional Chinese medicine compound with the function of dispersing nodules provided in this application, it can ensure the therapeutic effect of the drug preparation used to treat local muscle nodules.

[0061] Optionally, the plaster base may further include at least one of traditional plant oil bases with good adhesion, such as sesame oil, castor oil, tung oil, etc.

[0062] Optionally, the plaster matrix may further include at least one of traditional natural resin preparations with good adhesion, such as rosin and beeswax.

[0063] Optionally, the plaster matrix may further include at least one of gel matrices prepared with gel forming agents such as gelatin, gum arabic, pectin, carbomer, xanthan gum, and ammonium alginate. Such plaster matrices have good transparency, a cool feel on the skin, and good analgesic and antipyretic effects.

[0064] Alternatively, the plaster base may include at least one water-soluble base prepared from polymer materials such as PVP (polyvinyl pyrrolidone), sodium carboxymethyl cellulose (CMC-Na), PVA (polyvinyl alcohol), HEC (hydroxyethyl cellulose), and HPMC (hydroxypropyl methyl cellulose) in combination with plasticizers such as glycerol and propylene glycol. This type of plaster base has good air permeability, is easy to clean after application, and is less irritating, making it suitable for use on swollen, painful, and sensitive skin.

[0065] Alternatively, the plaster base may also include an emulsion-type base comprising an oil phase, an aqueous phase, and an emulsifier. This type of plaster base has a soft texture, good moisturizing effect, and can carry fat-soluble drugs. The oil phase may include at least one of liquid paraffin and stearic acid. The aqueous phase may include at least one of water, glycerol, and propylene glycol. The emulsifier may include at least one of Tween and Span.

[0066] Optionally, the plaster matrix may further include at least one of pressure-sensitive adhesive matrices such as acrylic, silicone, and natural rubber.

[0067] Optionally, the plaster matrix may also include a polymer material matrix prepared by mixing colloids such as EVA (ethylene-vinyl acetate copolymer) and PU (polyurethane) with biocompatible materials such as chitosan and hyaluronic acid.

[0068] Optionally, the plaster matrix may also include biodegradable matrices such as PLA (polylactic acid) and PCL (polycaprolactone).

[0069] In a specific embodiment of the present application, the mass ratio of the drug powder to the vaseline is 1:(1-2). When the mass ratio of the drug powder to the vaseline is 1:(1-2), the vaseline can be evenly blended with the drug powder, so that the prepared drug preparation does not suffer from the problems of easy drying, easy shedding, poor ductility, and poor adhesion caused by too little plaster base, nor does it suffer from the problem of limited therapeutic effect caused by too much plaster base and too little drug powder. Therefore, the usability and efficacy of the drug preparation for treating local muscle induration can be taken into account.

[0070] The following are examples and comparative examples of pharmaceutical preparations provided in this application for treating local muscle induration.

[0071] Example 1

[0072] Mix 80mg of Astragalus, 80mg of Raw Oyster, and 20mg of Scutellaria Baicalensis and grind them into a powder. Then, mix 180mg of petroleum jelly with the powder in a 1:1 mass ratio to prepare a pharmaceutical preparation for treating localized muscle induration. Apply a 0.2cm to 0.5cm thick layer of the pharmaceutical preparation to the site of progesterone intramuscular injection. Apply medical tape to the site of progesterone intramuscular injection to secure and protect the pharmaceutical preparation. Keep the pharmaceutical preparation applied to the site of progesterone intramuscular injection for 2 to 4 hours. Repeat this process once daily after the intramuscular progesterone injection.

[0073] Comparative Example 1

[0074] Take a fresh, clean potato, peel it, and slice it into thin slices approximately 2 mm thick. Place the slices over the site where the patient received the intramuscular progesterone injection, and cover the potato with plastic wrap. Keep the slices in place for 1 to 2 hours. Repeat this process 2 or 3 times daily after the intramuscular progesterone injection.

[0075] Patients who had received intramuscular progesterone were divided into an observation group (128 patients) and a control group (100 patients). The observation group was treated using the method provided in Example 1, while the control group was treated using the method provided in Comparative Example 1. After the same number of days of treatment, the therapeutic effects of the observation and control groups were observed using indicators such as the size, texture, and tenderness of the nodules at the intramuscular injection site.

[0076] The evaluation criteria for treatment effect are:

[0077] 1. Significant effect: No nodules appear at the site where the patient receives intramuscular progesterone injection, or the nodules are less than 5 cm in diameter, are soft, and have no tenderness or pain.

[0078] 2. Effective: Patients develop a lump at the site of intramuscular progesterone injection, and the diameter of the lump is between 5 cm and 10 cm. The lump is hard and slightly tender, but does not interfere with intramuscular injection.

[0079] 3. Ineffective: A lump appears at the site of intramuscular progesterone injection, and the diameter of the lump is greater than 10 cm, the texture is hard, there is obvious tenderness and it hinders intramuscular injection.

[0080] According to relevant clinical studies, the observation group treated with Example 1 showed significant results in preventing and treating muscle induration, with a total effective rate of 91.4%, while the control group treated with Comparative Example 1 had a total effective rate of 72%. This indicates that the traditional Chinese medicine compound with a knot-dispersing function provided by this application is more effective than traditional methods in preventing and treating muscle induration caused by intramuscular progesterone injection, and has obvious advantages.

[0081] The above description is only part of the implementation methods of the present application, and does not limit the scope of protection of the present application. Any equivalent device or equivalent process transformation made using the contents of the description and drawings of this application, or directly or indirectly used in other related technical fields, are also included in the scope of patent protection of this application.

Claims

1. A Chinese medicinal compound with a stagnation-dispersing function, characterized in that: Includes at least two of raw oysters, scutellaria baicalensis, and astragalus.

2. The Chinese medicinal compound with the function of dispersing nodules according to claim 1, characterized in that: The traditional Chinese medicine compound with the function of dispersing nodules comprises astragalus, raw oyster and scutellaria.

3. The Chinese medicinal compound with the function of dispersing nodules according to claim 2, characterized in that: Calculated by mass ratio, the Chinese medicinal compound with the function of dispersing knots contains 6 to 4 parts of astragalus, 6 to 4 parts of raw oyster and 1 to 2 parts of scutellaria.

4. The Chinese medicinal compound with the function of dispersing nodules according to claim 3, characterized in that: The mass ratio of astragalus, raw oyster and scutellaria is 4:4:

1.

5. A pharmaceutical preparation for treating local muscle induration, characterized in that: The pharmaceutical preparation for treating local muscle induration comprises the Chinese medicinal compound with the function of dispersing induration according to any one of claims 1 to 4 and optional pharmaceutically acceptable excipients.

6. The pharmaceutical preparation for treating local muscle induration according to claim 5, characterized in that The pharmaceutical preparation for treating local muscle induration includes an external ointment.

7. Use of the pharmaceutical preparation for treating local muscle induration according to claim 5 or claim 6 in alleviating induration caused by intramuscular injection of progesterone.

8. A method for preparing a pharmaceutical preparation for treating local muscle induration, characterized in that: include: Mixing and grinding at least one of Astragalus and Scutellaria with raw oyster to prepare a medicinal powder; The drug powder is mixed with a plaster matrix to prepare the drug preparation for treating local muscle induration.

9. The method for preparing the pharmaceutical preparation for treating local muscle induration according to claim 8, characterized in that: The plaster base includes petrolatum.

10. The method for preparing the pharmaceutical preparation for treating local muscle induration according to claim 9, characterized in that: The mass ratio of the drug powder to vaseline is 1:(1-2).

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