Traditional Chinese medicine composition for eye diseases, traditional Chinese medicine patch, preparation method and application

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for eye diseases, a traditional Chinese medicine patch, a preparation method and application, and the traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials in parts by weight: 0.5-2 parts of radix rehmanniae recen, 0.5-2 parts of radix ophiopogonis, 1-4 parts of chrysanthemum and 1-4 parts of nux prinsepiae. The traditional Chinese medicine composition can effectively prevent and / or treat eye diseases, and is simple in components, low in toxic and side effects, safe and reliable.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition, a traditional Chinese medicine patch, a preparation method and an application thereof for treating eye diseases. Background Art

[0002] Currently, Western medical treatments for eye conditions such as dry eyes, eye strain, and visual fatigue include artificial tear therapy, physical therapy, and lifestyle adjustments. Artificial tear therapy involves using eye drops such as sodium hyaluronate and chondroitin sulfate to relieve dryness. Physical therapy involves applying warm compresses (40-60°C hot towels) to promote blood circulation, or alternating hot and cold compresses to relieve fatigue. Lifestyle adjustments include adopting the 20-20-20 rule (looking at an object 20 feet away for 20 seconds every 20 minutes), supplementing with vitamins A / C (carrots and broccoli) and omega-3 (deep-sea fish), avoiding prolonged electronic device use, and wearing blue-light-blocking glasses. Traditional Chinese medicine treatments include syndrome differentiation based on Chinese medicine, such as Qiju Dihuang Wan, Shihu Yeguang Wan, and Longdan Xiegan Wan. Eye massage involves massaging acupoints such as Jingming, Sibai, and Taiyang. Acupuncture involves stimulating acupoints on the liver and kidney meridians (such as Taichong and Sanyinjiao) to regulate qi and blood. However, the effectiveness of these treatments for eye conditions is limited.

[0003] In view of this, the present invention is proposed. Summary of the Invention

[0004] In order to overcome the deficiencies in the above-mentioned prior art, the present invention addresses the technical problem of limited efficacy of existing treatments for eye diseases and proposes a traditional Chinese medicine composition, a traditional Chinese medicine patch, a preparation method and an application thereof for eye diseases.

[0005] The first aspect of the present invention provides a traditional Chinese medicine composition for eye diseases, which comprises the following traditional Chinese medicines in parts by weight: 0.5-2 parts by weight of Rehmannia root, 0.5-2 parts by weight of Radix Ophiopogonis, 1-4 parts by weight of Chrysanthemum and 1-4 parts by weight of Semen Rhizoma Cynanchifoliae.

[0006] The detailed pharmacology of the above components are as follows:

[0007] Rehmannia root: Sweet and bitter in flavor, cold in nature, enters the Heart, Liver, and Kidney meridians. It clears heat, promotes fluid production, cools the blood, and stops bleeding. It is used for yin damage caused by febrile illnesses, red tongue and thirst, rash caused by warm toxins, hematemesis, epistaxis, and sore throat.

[0008] Ophiopogon japonicus: Sweet, slightly bitter, and slightly cold. It enters the Heart, Lung, and Stomach meridians. It nourishes Yin and produces fluid, moistens the lungs, and relieves coughs. It is used for symptoms of lung and stomach Yin deficiency, such as thirst, dry cough, and hemoptysis; heart Yin deficiency, such as palpitations and fright, and late-stage fever, where heat damages body fluids. Combined with Adenophora Root and Fritillaria cirrhosa, it can treat dry coughs caused by lung Yin deficiency.

[0009] Chrysanthemum: Bitter and sweet, slightly cold in nature, it enters the lung and liver meridians. It dispels wind and heat, soothes the liver and improves eyesight, and clears heat and detoxifies. It is used for wind-heat colds, headaches and dizziness, red and swollen eyes, blurred vision, and sores, carbuncles, and swelling.

[0010] Rhizoma Rugosae: sweet, slightly cold, enters the liver meridian. It nourishes the liver and improves eyesight, dispels wind and dissipates heat, and is used for red, swollen and painful eyes, red and rotten eyelids, and dark eyes and photophobia.

[0011] In summary, it can be seen that the Chinese medicine composition of the present invention also has sufficient theoretical support at the level of modern pharmacological research, and the Chinese medicine composition of the present invention has a good therapeutic and / or preventive effect on eye diseases.

[0012] The prescription of the Chinese medicine composition of the present invention is explained as follows:

[0013] According to Traditional Chinese Medicine's Five Wheels theory, the eye is divided into five wheels, corresponding to the functions of the five internal organs: the Water Wheel (pupil), which belongs to the kidneys, reflects the surplus or deficiency of kidney essence. Insufficient kidney essence leads to blurred vision. The Wind Wheel (black eye), which belongs to the liver, nourishes the black eye with liver blood. The Blood Wheel (blood vessels in the inner and outer canthi), which belongs to the heart. Insufficient heart blood can cause congestion or stinging in the corners of the eyes, while excessive heart fire can cause redness and mucus in the eyes. The Qi Wheel (white eye), which belongs to the lungs, causes congestion in the white of the eye. The Flesh Wheel (eyelid), which belongs to the spleen, causes swollen or drooping eyelids. Those with excessive spleen dampness experience morning eye swelling. The liver and kidneys are the core organs of the body. "The liver opens the eyes," and liver blood directly nourishes the eyes. "The kidneys store essence, essence produces marrow, and marrow connects to the brain." Kidney essence is transported to the eyes through meridians, maintaining visual function. Qi and blood are transported to the eyes through meridians, such as the Foot Jueyin Liver Meridian and the Hand Shaoyin Heart Meridian, which are connected to the eyes. Insufficient or poorly circulated Qi and blood can lead to dry eyes and visual fatigue. In summary, Traditional Chinese Medicine improves eyesight by regulating liver and kidney functions and promoting Qi to nourish the eyes.

[0014] The causes and pathogenesis of eye diseases include the following aspects: (1) Exogenous factors: Six pathogenic factors: Wind, cold, heat, dampness, dryness, fire and other external pathogens invade the eyes through the meridians or directly. (2) Internal factors: Seven emotional imbalance: Anger, joy, worry, thought and other emotional extremes affect the qi of the internal organs. For example, liver depression and fire can cause red and painful eyes, long-term worry and thought can damage the spleen, and insufficient qi and blood production can cause blurred vision. (3) Diet and fatigue: Excessive consumption of spicy, fatty and sweet foods can produce phlegm and dampness, blocking the eye meridians; long-term vision and fatigue can damage the essence and blood, leading to dry eyes or myopia. (4) Other factors: Trauma, directly damaging the eye meridians or tissues, causing blood stasis and edema (such as traumatic retinopathy). Congenital deficiency, liver and kidney essence and blood deficiency, leading to congenital amblyopia, strabismus, etc. are the factors of the disease. And liver blood deficiency, kidney essence deficiency, spleen and stomach weakness and other internal organ dysfunction are the basic pathogenesis.

[0015] It can be seen that the etiology and pathogenesis of eye diseases are closely related. The Chinese medicine composition of the present invention comprehensively and dialectically analyzes eye diseases, and through the rational combination of monarch, minister, assistant and envoy, it takes clearing the liver and purging heat, nourishing yin and improving eyesight as the main treatment principles. The idea of ​​formulating the prescription is: chrysanthemum is the monarch medicine for clearing the liver and improving eyesight, and raw rehmannia is the minister medicine, which nourishes kidney yin to achieve the effect of nourishing water, containing wood and nourishing the liver. Ophiopogon japonicus is a sweet and cold adjuvant, which helps raw rehmannia to nourish yin, and at the same time clears heart fire and eliminates the heat of inflammation in the inner and outer canthus of the eyes. Rhizoma ...

[0016] Optionally, the traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 0.5-2 parts by weight of raw rehmannia root, 0.5-2 parts by weight of ophiopogon japonicus, 1-4 parts by weight of chrysanthemum and 1-4 parts by weight of rhubarb, and the amount of chrysanthemum and rhubarb is greater than the amount of raw rehmannia root and ophiopogon japonicus.

[0017] In this prescription, chrysanthemum clears the liver and improves eyesight, and its medicinal property is frivolous and can lead the medicine upward, so the dosage is too large. Rehmannia root clears heat and cools blood and enters the kidney meridian. According to the liver and kidney are of the same origin and the five-wheel theory, the black eye belongs to the kidney, which has the effect of nourishing the kidney and improving eyesight. At the same time, its nature is heavy, and the dosage should not be too large to prevent the medicine from going down into the kidney, so its dosage is less than that of the monarch medicine chrysanthemum. Ophiopogon japonicus is moist and clears the heart, effectively relieving congestion in the inner and outer canthus of the eye. Because it is greasy and nourishing, excessive dosage is not conducive to the processing of powder. Clinical experience shows that this ratio is more appropriate. Radix Rhizoma ...

[0018] Optionally, the traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 0.5-1 parts by weight of Rehmannia root, 0.5-1 parts by weight of Radix Ophiopogonis, 1-2 parts by weight of Flos Chrysanthemi and 1-2 parts by weight of Semen Rhizoma Cynomorii.

[0019] Optionally, the traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 1-2 parts by weight of Rehmannia root, 1-2 parts by weight of Radix Ophiopogonis, 2-4 parts by weight of Flos Chrysanthemi and 2-4 parts by weight of Semen Rhizoma Cynomorii.

[0020] Optionally, the traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 1 part by weight of Rehmannia root, 1 part by weight of Radix Ophiopogonis, 2 parts by weight of Flos Chrysanthemi and 2 parts by weight of Semen Rhizoma Cynanchifoliae.

[0021] The Chinese medicine composition of the present invention can be prepared into a powder, ointment, or patch. During use, the ointment can be applied directly to the bilateral liver shu acupoints, or the powder can be prepared into a medicine bag and applied to the bilateral liver shu acupoints. The patch can also be applied directly to the bilateral liver shu acupoints. The Chinese medicine composition of the present invention can also be prepared into a medicine bag and placed in an eye mask, playing a role in treating and / or preventing eye diseases while the child is wearing the eye mask. In actual application, the Chinese medicine dosage form can be flexibly selected based on a comprehensive consideration of the method of administration, the location of administration, and the efficacy.

[0022] The second aspect of the present invention provides a traditional Chinese medicine patch for eye diseases, wherein the traditional Chinese medicine preparation comprises a carrier and the traditional Chinese medicine composition for eye diseases proposed in the first aspect of the present invention.

[0023] Optionally, the Chinese medicine patch further comprises rice vinegar, and the ratio of the Chinese medicine composition to the rice vinegar is 1:1-2.

[0024] Optionally, the carrier includes non-woven fabric, gauze, adhesive tape, adhesive plaster or medical rubber.

[0025] The third aspect of the present invention provides a method for preparing a Chinese medicine patch for eye diseases, which is applied to the Chinese medicine patch for eye diseases proposed in the second aspect of the present application, and the preparation method comprises:

[0026] Weigh each Chinese medicinal material by weight and mix them;

[0027] The mixed Chinese medicinal materials are crushed and passed through a 40-100 mesh sieve, preferably an 80 mesh sieve, to obtain a powdered Chinese medicinal mixture;

[0028] Adding auxiliary materials to the powdered Chinese medicine mixture to prepare a dressing;

[0029] The dressing is placed on a carrier to prepare a Chinese medicine patch. In practical applications, the dressing can be prepared into a medicine ball, which is then pressed into a cake shape, and then the cake-shaped dressing is placed on a carrier to obtain the Chinese medicine patch.

[0030] An optional method of using the Chinese medicine patch of the present invention is as follows:

[0031] Treatment course: Apply for two weeks continuously, one patch a day, two hours each time;

[0032] Dosage: External acupuncture point application, apply to the liver points on both sides.

[0033] The fourth aspect of the present invention provides a use of the traditional Chinese medicine composition for eye diseases proposed in the first aspect of the present invention or the traditional Chinese medicine patch for eye diseases proposed in the second aspect of the present invention in the preparation of a medicine, wherein the medicine is used to prevent and / or treat eye diseases in children, including vision fluctuations, eye discomfort and accommodative abnormalities.

[0034] Among them, the vision fluctuations manifest as temporary vision loss or blurred vision, which can be partially recovered after rest; the eye discomfort manifests as dry eyes, soreness, photophobia, foreign body sensation, and even pain or headache around the eye sockets; the accommodation abnormalities manifest as slow focusing and double vision after close-range use of the eyes.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] The Chinese medicine composition and Chinese medicine patch of the present invention have good therapeutic effects on eye diseases, have simple and reasonable formulas, have little toxic and side effects, are safe and reliable, and after the Chinese medicine composition is made into a Chinese medicine patch, it is convenient to use and easily accepted by children, and is especially suitable for children's eye diseases. DETAILED DESCRIPTION

[0037] The present invention is further illustrated below by describing specific implementation methods, but this is not intended to limit the present invention. Those skilled in the art can make various modifications or improvements based on the basic ideas of the present invention, but as long as they do not deviate from the basic ideas of the present invention, they are all within the scope of the present invention.

[0038] Example 1

[0039] Step 1: Weigh 1 part by weight of Radix Rehmanniae, 1 part by weight of Radix Ophiopogonis, 2 parts by weight of Flos Chrysanthemi, and 2 parts by weight of Semen Rhizoma ...

[0040] Step 2: Grind the mixed Chinese medicinal materials and pass them through an 80-mesh sieve to obtain a powdered Chinese medicinal mixture;

[0041] Step 3: Add rice vinegar to the powdered Chinese medicine mixture to prepare a dressing, wherein the ratio of the Chinese medicine composition to the rice vinegar is 1:1.

[0042] Step 4: placing the dressing on a carrier to prepare a Chinese medicine patch;

[0043] Examples 2 to 10: Traditional Chinese medicine patches were prepared according to the preparation method of Example 1 using the formula, sieving process and preparation ratio in Table 1.

[0044] Table 1: Components, sieving conditions and blending ratios of each Chinese medicinal material in Examples 2-10

[0045]

[0046]

[0047] Test example

[0048] This test example is a clinical study on the use of the Chinese medicine patch prepared from the Chinese medicine composition of Example 1 in treating eye diseases.

[0049] Case selection: Sixty children with eye diseases were randomly selected from Beijing Huimin Children's Hospital of Traditional Chinese Medicine. The average age of the children was 6 years and 8 months, and the male to female ratio was 1:1.

[0050] 1. Patient grouping:

[0051] The control group and the experimental group were divided into groups based on the same number of men and women, the same average age, the same main symptoms, and similar severity.

[0052] 2. Diagnosis is based on:

[0053] (1) Symptom assessment

[0054] Vision fluctuations: manifested as temporary decreased vision or blurred vision, which can be partially recovered after rest;

[0055] Eye discomfort: including dryness, soreness, photophobia, foreign body sensation, and even pain around the eye sockets or headache;

[0056] Accommodation abnormalities: slow focusing and double vision after using the eyes at close range.

[0057] (2) Analysis of medical history and eye habits

[0058] Eye intensity: History of prolonged use of electronic products, reading, or fine work (more than 40 minutes without a break)

[0059] Environmental factors: insufficient / excessive light, exposure to blue light from the screen, or dry environment in an air-conditioned room.

[0060] Systemic condition: Lack of sleep, mental stress, or systemic diseases (such as diabetes, thyroid disease) may aggravate symptoms.

[0061] (3) Medical examination items

[0062] Basic examination:

[0063] Vision test: Assess both uncorrected and corrected visual acuity.

[0064] Slit lamp examination: Observe the cornea, conjunctiva and other structures for abnormalities.

[0065] Functional test:

[0066] Optometry and accommodation function test: confirm the degree of myopia / hyperopia / astigmatism through dilated pupil refraction and evaluate the accommodation ability of the ciliary muscle.

[0067] 3. Medication process: The Chinese medicine patch of this embodiment is applied to the bilateral Ganshu acupoints for 2 consecutive weeks, one patch per day, and each application lasts 2 hours.

[0068] 4. Scoring criteria: The commonly used Eye Strain Symptom Score (ESS) is used to subjectively assess the severity of eye fatigue and the effectiveness of treatment. The Eye Strain Symptom Score is shown in Table 2.

[0069] Table 2 Eye fatigue symptom scoring table

[0070]

[0071]

[0072] 5. Total score calculation and grading:

[0073] 5.1 Total score range: 0 to 27 points (sum of 9 symptoms).

[0074] 5.2 Severity Grading:

[0075] 0-5 points: normal / mild (no intervention required).

[0076] 6-12 points: Mild eye fatigue (it is recommended to adjust eye habits).

[0077] 13-18 points: Moderate eye fatigue (medical intervention required).

[0078] ≥19 points: severe eye fatigue (requires detailed eye examination).

[0079] 6 Reference for efficacy assessment

[0080] Markedly effective: total score decreased by ≥50%;

[0081] Effective: total score decreased by 20% to 50%;

[0082] Ineffective: total score decreased by <20% or worsened.

[0083] 7. Experimental results: The statistical data of the symptom scores of the same children before and after taking the medicine are shown in Table 3. Table 3 Statistics of the symptom scores of the same children before and after taking the medicine

[0084]

[0085]

[0086] From the above results, it can be seen that after using the Chinese medicine patch of this embodiment, the eye symptoms of most children were effectively alleviated, with an effective rate of more than 75%, and no obvious adverse reactions were found during the treatment process.

[0087] 8. Case analysis:

[0088] A 6-year-old boy recently developed dry, painful eyes and an irritable temper due to prolonged reading and study. Artificial tear application provided some relief, but the symptoms subsequently returned, along with red and painful eyes, a bitter taste in the mouth, and a dry throat. Physical examination revealed conjunctival hyperemia, a reddened tongue with raised tongue papillae, and a thready, stringy pulse. Diagnosis indicated excessive liver fire, and treatment principles included clearing the liver and purging heat, nourishing yin, and improving eyesight. Topical eye-clearing patches were used for treatment. After one week, the eye pain subsided, the dryness eased, the conjunctival hyperemia subsided slightly, and the irritable temper resolved. The results were satisfactory, and topical application was continued for another week to consolidate the effect.

[0089] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for eye diseases, characterized in that: The traditional Chinese medicine composition comprises the following traditional Chinese medicine materials in parts by weight: 0.5-2 parts by weight of raw rehmannia root, 0.5-2 parts by weight of ophiopogon japonicus, 1-4 parts by weight of chrysanthemum and 1-4 parts by weight of rhubarb seed.

2. The Chinese medicine composition for eye diseases according to claim 1, characterized in that The traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 0.5-2 parts by weight of raw rehmannia root, 0.5-2 parts by weight of ophiopogon japonicus, 1-4 parts by weight of chrysanthemum and 1-4 parts by weight of rhubarb, and the amount of the chrysanthemum and the rhubarb is greater than the amount of the raw rehmannia root and the ophiopogon.

3. The Chinese medicine composition for eye diseases according to claim 1, characterized in that: The traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 0.5-1 parts by weight of raw rehmannia root, 0.5-1 parts by weight of ophiopogon japonicus, 1-2 parts by weight of chrysanthemum and 1-2 parts by weight of rhubarb seed.

4. The Chinese medicine composition for eye diseases according to claim 1, characterized in that The traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 1-2 parts by weight of raw rehmannia root, 1-2 parts by weight of ophiopogon japonicus, 2-4 parts by weight of chrysanthemum and 2-4 parts by weight of rhubarb seed.

5. The Chinese medicine composition for eye diseases according to claim 1, characterized in that: The traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 1 part by weight of raw rehmannia root, 1 part by weight of ophiopogon japonicus, 2 parts by weight of chrysanthemum and 2 parts by weight of rhubarb seed.

6. A Chinese medicine patch for eye diseases, characterized in that: The traditional Chinese medicine preparation comprises a carrier and the traditional Chinese medicine composition for eye diseases according to any one of claims 1 to 5.

7. The Chinese medicine patch for eye diseases according to claim 6, characterized in that: The Chinese medicine patch also includes rice vinegar, and the ratio of the Chinese medicine composition to the rice vinegar is 1:1-2.

8. The Chinese medicine patch for eye diseases according to claim 6, characterized in that: The carrier includes non-woven fabric, gauze, adhesive tape, adhesive plaster or medical rubber.

9. A method for preparing a Chinese medicine patch for eye diseases, characterized in that: The preparation method is applied to the traditional Chinese medicine patch for eye diseases according to any one of claims 6 to 8, and the preparation method comprises: Weigh each Chinese medicinal material by weight and mix them; The mixed Chinese medicinal materials are crushed and passed through a 40-100 mesh sieve to obtain a powdered Chinese medicinal mixture; Adding auxiliary materials to the powdered Chinese medicine mixture to prepare a dressing; The dressing is placed on a carrier to prepare a Chinese medicine patch.

10. Use of the traditional Chinese medicine composition for eye diseases according to any one of claims 1 to 6 or the traditional Chinese medicine patch for eye diseases according to any one of claims 6 to 8 in the preparation of medicines, characterized in that: The medicament is used for preventing and / or treating pediatric eye disorders, including vision fluctuations, eye discomfort and accommodation abnormalities.

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