Vacuum blood sampling centrifugal tube

Abstract

The invention relates to the technical field of blood sampling centrifugal tubes, and discloses a vacuum blood sampling centrifugal tube which comprises an outer tube, an inner tube, an extraction opening, an insertion hole block, an upper tube cap and a lower tube cap. Through the structural design of the extraction opening in the side wall, the breakthrough closed layered liquid extraction technology is achieved, the extraction opening is directly communicated with the inner pipe to form a closed liquid extraction channel, and therefore an operator can complete flat layer extraction of a target component layer in a completely closed environment without opening an upper pipe cap; air contact pollution caused by traditional uncovering liquid taking is fundamentally eradicated; meanwhile, the extraction opening preset at the height of the target liquid layer can be directly aligned with the required components for precise extraction, so that component mixing caused by the fact that a puncture needle penetrates through the upper-layer liquid is completely avoided, it is ensured that the target component with the highest purity is obtained, the whole liquid extraction process is completed in a completely-closed pipeline system, and the extraction efficiency is improved. The biological safety and component integrity of blood products are guaranteed, and high-yield extraction of target components can be achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical centrifugal equipment and consumables, in particular to a vacuum blood collection centrifuge tube. Background Art

[0002] Among current blood component separation technologies, centrifugation remains the mainstream method for extracting platelets and other blood components (such as plasma and red blood cells). Conventional procedures require the use of specialized blood collection centrifuge tubes. After separating the blood at a specific speed and time, the tube cap is manually opened and a pipette is used to penetrate the interlayer interface (such as the platelet-rich buffy coat) to extract targeted components.

[0003] To extract fluid from different layers after centrifugation, existing centrifuge tubes require opening the tube's lid and passing through the upper liquid layer, exposing the blood product to the environment and potentially causing bacterial contamination. Furthermore, when passing through the upper liquid layer to reach the target liquid layer, the upper and lower liquid layers will inevitably mix, making extraction difficult and preventing the extraction of high-purity, effective liquid layer material. Summary of the Invention

[0004] In view of the above problems existing in the existing blood collection centrifuge tube, the present invention is proposed.

[0005] Therefore, the purpose of the present invention is to provide a vacuum blood collection centrifuge tube, the purpose of which is to open a hole at any required position on the side of the vacuum blood collection centrifuge tube, which can withstand the set positive and negative pressures and facilitate accurate liquid collection from the side.

[0006] In order to solve the above technical problems, the present invention provides the following technical solution: it includes an outer tube, an inner tube, an extraction port, an insertion hole block, an upper tube cap and a lower tube cap, the inner tube is inserted into the inner cavity of the outer tube, the extraction port is opened on the outside of the outer tube, and the extraction port passes through the outer tube to the inner cavity of the inner tube, the end of the inner tube is sleeved with an insertion hole block for inserting a blood collection needle, one end of the outer tube is threadedly installed with an upper tube cap, and the other end of the outer tube is threadedly installed with a lower tube cap.

[0007] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, an annular gap is formed between the outer tube and the inner tube, and the gap is used to buffer the impact of blood flow during centrifugation.

[0008] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, the inner diameter of the inner tube is adapted to the outer diameter of the blood collection needle, ensuring that the needle and the inner wall of the inner tube are tightly matched during blood collection.

[0009] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, the axial position of the extraction port corresponds to the height of the platelet-rich layer after centrifugation.

[0010] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, the inner diameter of the extraction port is designed to be 3 to 5 mm, which is convenient for inserting a pipette tip or a syringe needle.

[0011] As a preferred solution of the vacuum blood collection centrifuge tube of the present invention, the insertion hole block is made of elastic silicone material, and a self-sealing puncture hole is provided in the center thereof.

[0012] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, the threads of the upper tube cap and the lower tube cap are rotated in opposite directions to prevent them from loosening during centrifugation.

[0013] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, an annular sealing gasket is provided on the inner surface of the upper tube cap to form an airtight connection with the end of the outer tube.

[0014] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, the outer surfaces of the upper tube cap and the lower tube cap are provided with anti-slip patterns to facilitate the tightening operation.

[0015] As a preferred embodiment of the vacuum blood collection centrifuge tube of the present invention, the outer tube and the inner tube are integrally injection-molded using transparent medical-grade polypropylene material.

[0016] The beneficial effects of the present invention are as follows: through the structural design of the side wall extraction port, a breakthrough closed layered liquid extraction technology is realized. The extraction port is directly connected to the inner tube to form a closed liquid extraction channel, so that the operator can complete the flat-layer extraction of the target component layer in a completely closed environment without opening the upper tube cap, fundamentally eliminating the air contact pollution caused by traditional opening the cover to extract liquid; at the same time, the extraction port preset at the target liquid layer height can be directly aimed at the required component for precise extraction, completely avoiding the mixing of components caused by the puncture needle penetrating the upper liquid, ensuring the highest purity of the target component, and completing the entire liquid extraction process in a completely closed pipeline system, which not only ensures the biological safety and component integrity of blood products, but also achieves high-yield extraction of target components, solving the problem that the traditional centrifuge tube liquid extraction method is difficult to strike a balance between safety and purity. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] To more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. Those skilled in the art can also derive other drawings based on these drawings without inventive effort. Among them:

[0018] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0019] Figure 2It is an exploded view of the overall structure of the present invention.

[0020] Figure 3 It is a cross-sectional view of the overall structure of the present invention.

[0021] In the figure: 1, outer tube; 2, inner tube; 3, extraction port; 4, insertion hole block; 5, upper tube cap; 6, lower tube cap. DETAILED DESCRIPTION

[0022] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0023] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0024] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive of other embodiments.

[0025] Furthermore, the present invention is described in detail with reference to schematic diagrams. For ease of illustration, when describing the embodiments of the present invention, cross-sectional views illustrating device structures may be partially enlarged and not to scale. Furthermore, the schematic diagrams are merely illustrative and should not limit the scope of protection of the present invention. Furthermore, in actual production, the three-dimensional dimensions of length, width, and depth should be included.

[0026] Example 1

[0027] Reference Figures 1 to 3 , which is the first embodiment of the present invention, provides a vacuum blood collection centrifuge tube, which includes an outer tube 1, an inner tube 2, an extraction port 3, an insertion hole block 4, an upper tube cap 5 and a lower tube cap 6. The inner tube 2 is inserted into the inner cavity of the outer tube 1, and the extraction port 3 is opened on the outside of the outer tube 1, and the extraction port 3 passes through the outer tube 1 to the inner cavity of the inner tube 2. The end of the inner tube 2 is provided with an insertion hole block 4 for inserting a blood collection needle. The upper tube cap 5 is threadedly installed on one end of the outer tube 1, and the lower tube cap 6 is threadedly installed on the other end of the outer tube 1.

[0028] Among them, through the nested structure of the outer tube 1 and the inner tube 2 and the design of the extraction port 3, direct flat extraction of the blood component layer after centrifugation is achieved from the side, completely avoiding the contamination risk caused by the traditional method of opening the upper tube cap 5 and passing through the upper liquid surface. At the same time, the insertion of the hole block 4 ensures the sealing during blood collection. The double sealing design of the upper tube cap 5 and the lower tube cap 6 not only ensures the negative pressure maintenance performance of vacuum blood collection, but also can withstand the positive pressure generated during centrifugation.

[0029] Specifically, an annular gap is formed between the outer tube 1 and the inner tube 2, which is used to buffer the impact of blood flow during centrifugation. The inner diameter of the inner tube 2 is adapted to the outer diameter of the blood collection needle, ensuring that the needle and the inner wall of the inner tube 2 fit tightly during blood collection.

[0030] Among them, the annular gap design between the outer tube 1 and the inner tube 2 plays a buffering role during the centrifugation process, effectively absorbing the impact force generated by the blood flow, and preventing the destruction of the blood component layer due to centrifugal force, thereby ensuring the integrity and purity of each component layer during the subsequent flat layer extraction through the extraction port 3; the precise matching design of the inner diameter of the inner tube 2 and the blood collection needle ensures the airtightness of the blood collection process, maintains the negative pressure state of vacuum blood collection, and avoids blood leakage, creating an ideal closed environment for subsequent centrifugal separation and side flat layer extraction, ensuring the biological safety of blood products.

[0031] Furthermore, the axial position of the extraction port 3 corresponds to the height of the platelet-rich layer after centrifugation, and the inner diameter of the extraction port 3 is designed to be 3 to 5 mm, which is convenient for inserting a pipette tip or a syringe needle.

[0032] Among them, the specific axial position setting of the extraction port 3 can directly correspond to the height of the platelet-rich layer after centrifugation, realizing the precise positioning of the target component layer, and completing the flat-layer extraction without penetrating the upper liquid surface, thereby ensuring the purity and yield of the extracted components to the greatest extent, while avoiding cross-contamination of the component layers. The 3-5mm inner diameter design of the extraction port 3 can ensure the smooth insertion of the pipette tip or syringe needle, while maintaining good sealing performance, maintaining the pressure balance in the tube during the extraction process, ensuring the stability of the vacuum negative pressure, and preventing pressure leakage due to an excessively large opening.

[0033] Preferably, the insertion hole block 4 is made of elastic silicone material, a self-sealing puncture hole is provided in the center thereof, and the threads of the upper tube cap 5 and the lower tube cap 6 are rotated in opposite directions to prevent loosening during centrifugation.

[0034] Among them, the insertion hole block 4 made of elastic silicone material and its self-sealing puncture hole design can automatically close after the blood collection needle is pulled out, effectively preventing blood leakage and air entry, maintaining the negative pressure environment of vacuum blood collection, and ensuring the sealing performance of the entire system to meet biosafety requirements. The upper tube cap 5 and the lower tube cap 6 adopt a thread design with opposite rotation directions to form an interlocking structure during the centrifugation process, effectively preventing the seal failure caused by the loosening of the tube cap, and ensuring the double sealing reliability of the system under positive pressure centrifugation and negative pressure blood collection conditions.

[0035] Furthermore, an annular sealing gasket is provided on the inner surface of the upper tube cap 5 to form an airtight connection with the end of the outer tube 1. The outer surfaces of the upper tube cap 5 and the lower tube cap 6 are provided with anti-slip patterns to facilitate the tightening operation.

[0036] Among them, the annular sealing gasket on the inner surface of the upper tube cap 5 enhances the airtight connection with the end of the outer tube 1, which not only ensures the negative pressure maintenance performance during vacuum blood collection, but also can withstand the internal positive pressure during the centrifugation process to prevent blood leakage and achieve true bidirectional pressure sealing. The anti-slip texture design on the bottom of the lower tube cap 6 enhances the grip during operation, facilitates the tightening and opening of the tube cap, ensures the reliability of the sealing connection, and avoids the risk of sealing failure due to improper operation.

[0037] Furthermore, the outer tube 1 and the inner tube 2 are integrally injection-molded using transparent medical-grade polypropylene material.

[0038] Among them, the outer tube 1 and inner tube 2 are made of transparent medical-grade polypropylene material by integral injection molding, which not only meets the biocompatibility requirements of medical devices, but also facilitates the observation of blood stratification in the tube, provides visual guarantee for the precise positioning of the extraction position of the extraction port 3, and ensures the strength and sealing performance of the overall structure under positive and negative pressure conditions.

[0039] During use, the blood collection needle is first inserted into the inner tube 2 through the insertion hole block 4 to complete the closed blood collection. After blood collection, when the needle is removed, the elastic silicone insertion hole block 4 automatically closes and maintains negative pressure. Then, the upper tube cap 5 and the lower tube cap 6 are tightened to form a double seal, and centrifugation is performed. After centrifugation, based on the blood stratification observed on the transparent tube wall, the pipette is aligned with the extraction port 3 preset at the target component layer height, and flat-layer extraction is directly performed without opening the lid or penetrating the upper liquid surface. This process achieves biosafety and precise component separation throughout the entire process of blood collection, centrifugation, and extraction under completely closed conditions.

[0040] In summary, through the nested structure of the outer tube 1 and the inner tube 2 and the innovative design of the side wall extraction port 3, fully enclosed blood component precise stratification extraction is achieved. During the blood collection stage, the insertion hole block 4 and the inner tube 2 form an airtight blood collection channel to ensure stable vacuum negative pressure. During the centrifugation stage, the upper tube cap 5 and the lower tube cap 6 with double reverse thread design cooperate with the annular gap buffer structure to effectively resist centrifugal positive pressure. During the extraction stage, the pre-positioned extraction port 3 can directly extract the target component layer in a flat layer, avoiding component contamination and stratification destruction caused by the traditional open-cap penetration method. It has both biosafety, pressure stability and operational visibility, and solves the problem of precise stratification and liquid extraction in a closed state of vacuum blood collection tubes.

[0041] Example 2

[0042] Reference Figure 3 , which is the second embodiment of the present invention. This embodiment is different from the first embodiment in that: the extraction port 3 is configured as a rotatable and adjustable structure, which includes an annular slide rail fixed on the outer tube 1 and a rotating sleeve with scale markings. The axial position of the extraction port 3 can be flexibly adjusted according to the centrifugal stratification height of different blood components, thereby realizing on-demand and precise extraction of multiple component layers.

[0043] Furthermore, the extraction port 3 is embedded with a magnetic valve plate, which is opened and closed by an external magnetic controller, further ensuring the sealing reliability in the non-liquid extraction state.

[0044] Furthermore, a spiral guide groove is added to the inner wall of the inner tube 2 to guide the blood to form a stable laminar flow during centrifugation, reduce the disturbance of turbulence on the stratification interface, make the boundaries of each component layer (such as plasma, platelets, and red blood cells) clearer, and improve the extraction accuracy.

[0045] When in use, first preset the centrifugal height of the target component layer such as platelets according to the blood testing requirements, rotate the sleeve to the corresponding scale position to lock the extraction port 3; after the centrifugation is completed, open the extraction port 3 through the external magnetic controller, and directly insert the pipette tip to extract the target layer, without opening the cover or penetrating the liquid layer during the whole process; after the operation is completed, the magnetic valve automatically resets to close the extraction port 3, and the remaining sample can continue to be stored or centrifuged again.

[0046] In summary, this embodiment not only retains the biosafety advantage of closed liquid extraction through the coordinated design of the adjustable extraction port 3 and the spiral guide groove, but also significantly improves the adaptability of the equipment to different detection requirements, and is particularly suitable for scenarios requiring multiple layered extractions or multi-index detection.

[0047] Example 3

[0048] Reference Figures 1 to 3 , which is the third embodiment of the present invention, differs from the second embodiment in that it provides an optimized vacuum blood collection step, specifically including the following operation process:

[0049] 1. Before blood collection, assemble the inner tube 2 and the insertion hole block 4 in advance to ensure that the self-sealing puncture hole is in a closed state;

[0050] 2. Tighten the upper tube cap 5 and the lower tube cap 6 to the specified torque to form an initial vacuum environment;

[0051] 3. When collecting blood, use a special puncture device to puncture the self-sealing puncture hole of the insertion hole block 4, and the blood automatically flows into the cavity of the inner tube 2 under the action of negative pressure;

[0052] 4. When the blood collection volume reaches the calibration mark, the puncture device is immediately pulled out. At this time, the elastic silicone material inserted into the hole block 4 automatically rebounds to close the puncture hole and maintain the vacuum state in the tube.

[0053] During use, place the centrifuge tube after blood collection into the centrifuge and set it to 3000rpm for centrifugation for 10 minutes; after centrifugation, observe the blood stratification in the transparent outer tube 1 to confirm the alignment position of the target component layer with the extraction port 3; use a sterile pipette to directly extract the required component layer through the extraction port 3, and keep the system completely closed during the whole process.

[0054] In summary, this embodiment ensures precise control of blood collection volume and minimizes the risk of contamination introduced by human operation through standardized vacuum blood collection steps and closed operation procedures, while maintaining the integrity of blood components. It is suitable for clinical application scenarios that require high-precision blood testing.

[0055] It is important to note that the construction and arrangement of the present application shown in a number of different exemplary embodiments are merely illustrative. Although only a few embodiments are described in detail in this disclosure, it should be readily understood by those who refer to this disclosure that many modifications are possible (e.g., the size, scale, structure, shape and proportion of various elements, as well as parameter values ​​(e.g., temperature, pressure, etc.), mounting arrangements, use of materials, color, directional changes, etc.) without departing substantially from the novel teachings and advantages of the subject matter described in this application. For example, an element shown as integrally formed may be composed of multiple parts or elements, the position of the element may be inverted or otherwise changed, and the nature or number or position of the discrete elements may be altered or changed. Therefore, all such modifications are intended to be included within the scope of the present invention. The order or sequence of any process or method steps may be changed or reordered according to alternative embodiments. In the claims, any "means plus function" clause is intended to cover the structure described herein that performs the function, and is not only structurally equivalent but also equivalent structures. Other replacements, modifications, changes, and omissions may be made in the design, operating conditions, and arrangement of the exemplary embodiments without departing from the scope of the present invention. Therefore, the invention is not limited to the specific embodiments, but extends to various modifications that still fall within the scope of the appended claims.

[0056] Additionally, in order to provide a concise description of exemplary embodiments, all features of an actual embodiment (ie, those features that are not relevant to the best mode presently contemplated for carrying out the invention or those that are not relevant to implementing the invention) may not be described.

[0057] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A vacuum blood collection centrifuge tube, characterized in that: The invention comprises an outer tube (1), an inner tube (2), an extraction port (3), an insertion hole block (4), an upper tube cap (5) and a lower tube cap (6); the inner tube (2) is inserted into the inner cavity of the outer tube (1); an extraction port (3) is opened on the outer side of the outer tube (1), and the extraction port (3) passes through the outer tube (1) and reaches the inner cavity of the inner tube (2); an insertion hole block (4) for inserting a blood collection needle is sleeved on the end of the inner tube (2); an upper tube cap (5) is threadedly installed on one end of the outer tube (1), and a lower tube cap (6) is threadedly installed on the other end of the outer tube (1).

2. The vacuum blood collection centrifuge tube according to claim 1, characterized in that: An annular gap is formed between the outer tube (1) and the inner tube (2), and the gap is used to buffer the impact of blood flow during centrifugation.

3. The vacuum blood collection centrifuge tube according to claim 2, characterized in that: The inner diameter of the inner tube (2) is adapted to the outer diameter of the blood collection needle, ensuring that the needle head and the inner wall of the inner tube (2) are tightly matched during blood collection.

4. The vacuum blood collection centrifuge tube according to claim 3, characterized in that: The axial position of the extraction port (3) corresponds to the height of the platelet-rich layer after centrifugation.

5. The vacuum blood collection centrifuge tube according to claim 4, characterized in that: The inner diameter of the extraction port (3) is designed to be 3-5 mm, which is convenient for inserting a pipette tip or a syringe needle.

6. The vacuum blood collection centrifuge tube according to claim 5, characterized in that: The insertion hole block (4) is made of elastic silicone material and has a self-sealing puncture hole at its center.

7. The vacuum blood collection centrifuge tube according to claim 6, characterized in that: The threads of the upper tube cap (5) and the lower tube cap (6) are rotated in opposite directions to prevent them from loosening during the centrifugation process.

8. The vacuum blood collection centrifuge tube according to claim 7, characterized in that: The inner surface of the upper tube cap (5) is provided with an annular sealing gasket, which forms an airtight connection with the end of the outer tube (1).

9. The vacuum blood collection centrifuge tube according to claim 8, characterized in that: The outer surfaces of the upper tube cap (5) and the lower tube cap (6) are provided with anti-slip patterns to facilitate the tightening operation.

10. The vacuum blood collection centrifuge tube according to claim 9, characterized in that: The outer tube (1) and the inner tube (2) are integrally injection-molded using a transparent medical-grade polypropylene material.

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