Cartridge with needle mounting blocking system for autoinjector

Abstract

The present invention relates to a cartridge with a telescopic needle shield, wherein the cartridge is adapted to be received in an autoinjector.

Description

Technical Field

[0001] The present invention relates to a cassette with a retractable needle shield, wherein the cassette is adapted to be received in an autoinjector. Background Art

[0002] There are many different types of autoinjectors for delivering medication to patients, depending on the type of medication to be delivered to the patient. When the autoinjector is a reusable syringe component that is inserted into a disposable cartridge, there are some key requirements that need to be met for each of the two components. Mechanical stability is required for the cartridge, but at the same time, it is generally also desirable to use minimal material in the disposable cartridge in order to keep production costs low and the environmental impact small. Patent application WO 2021 / 069106 A1 discloses an example of a system comprising a reusable autoinjector and a disposable cartridge, wherein the disposable cartridge is free of major electronic components and a spring system. Summary of the Invention

[0003] Different types of medications place different demands on storage conditions. Certain types of medications can deteriorate or otherwise become damaged if left in contact with metal for extended periods. This presents numerous challenges in storing cartridges containing syringes containing these types of medications, as the connection between the injection needle and the syringe compartment containing the medication can have undesirable consequences. Other cartridge systems can readily accommodate syringes that include a needle that is already connected to the syringe compartment and fluidically connected to the medication within the syringe compartment.

[0004] The automatic syringe used in combination with the box is usually customized for the size of different functional components in the box, and its purpose is to reduce the number of components in the box to a minimum, so that maximum stability is obtained in the system. However, reusable automatic syringes are with significant flexibility, because they can easily be programmed by software to optimize the delivery of different medicaments. Programmable variables can include injection delivery duration, maximum plunger force, etc. However, the optimization that the automatic syringe is provided with has been restricted to the design of the box.

[0005] Therefore, in a first aspect, the present invention discloses a box for use in an automatic injector for administering a medicament, wherein the box extends from a proximal end to a distal end in a longitudinal direction (L). The box includes a syringe holder configured to receive a syringe containing the medicament. The syringe may include a seal at the proximal end of the syringe that is configured to be pierced by a needle to obtain fluid communication between the medicament in the syringe and the needle. The syringe holder includes a needle assembly securing member at the proximal end of the syringe holder, wherein the needle assembly securing member is configured to secure a needle assembly including the needle to the syringe holder after the box is installed in the automatic injector.

[0006] The box also includes:

[0007] ●First needle safety cover;

[0008] a second needle safety cover, wherein the first needle safety cover is displaceable relative to the second needle safety cover in a longitudinal direction; and

[0009] One or more release arms, wherein the one or more release arms are movable between at least two positions relative to the syringe holder, the at least two positions comprising:

[0010] o an initial position (PraIN) in which the first needle safety cover and the second needle safety cover are separated by at most a first separation distance; and

[0011] o A release position (PraR), in which the first needle safety cover and the second needle safety cover are allowed to move relative to each other to a second separation distance greater than the first separation distance.

[0012] The cartridge according to the first aspect enables the use of an autoinjector that is initially designed and optimized to receive a cartridge system having a syringe with a pre-installed needle for delivering a medication from the cartridge system, wherein the syringe requires the user to connect the needle to the syringe compartment at the user's end. This alleviates the flexibility of autoinjectors, which are typically limited by cartridges provided in a specific physical form. This reduces the production cost of reusable autoinjectors because modifications to the cartridge allow the same reusable syringe to support medication delivery processes using different cartridge types. For example, if a pre-installed needle is not present, the cartridge according to the first aspect ensures that the needle safety cover allows both the installation of the needle and the covering of the needle after medication delivery using the same autoinjector as used for medication delivery from a cartridge with a pre-installed needle. This cartridge avoids introducing any changes to the autoinjector. Modifying the software control process of an electronic reusable autoinjector is generally quite easy because it can be performed without affecting the mechanical structure of such a system. However, the use of alternative cartridges typically requires mechanical modifications to the autoinjector, which is avoided by this cartridge. Thus, with a cartridge as described above, the specific requirements and needs of delivering a medicament from a particular cartridge can be captured and addressed without modifying the reusable auto-injector. This reduces the cost of purchasing a complex and durable reusable auto-injector.

[0013] The telescoping functionality of the needle safety cover system further ensures that the needle safety cover can be extended to allow both securing the injection needle to the cassette and covering the needle after the final dose is delivered.

[0014] The one or more release arms can be part of the second needle safety cover or the first needle safety cover. The one or more release arms can be replaced by a release finger, a release protrusion, or any other release device that controls the relative movement of the first and second needle safety covers between the initial position and the released position. The second separation distance can be the extended position. The relative movement between the two needle safety cover components can be considered a telescopic movement.

[0015] The proximal movement of the first needle safety cover can allow the two needle safety covers to extend telescopically.Thus, the distance between the first needle safety cover and the second needle safety cover increases.

[0016] In a second aspect, disclosed herein is a cartridge for use in an autoinjector for administering a medicament, wherein the cartridge extends in a longitudinal direction (L) from a proximal end to a distal end. The cartridge comprises:

[0017] Needle safety cover;

[0018] An indexing ring rotatable relative to the needle safety cover between a plurality of rotational positions, the plurality of rotational positions comprising at least:

[0019] o a first rotational position (R1) in which the needle safety cover is prevented from distal movement; and

[0020] ○ A second rotational position (R2), in which the needle safety cover can be longitudinally

[0021] Toward movement;

[0022] A syringe holder configured to receive a syringe containing a medicament, the syringe comprising a seal at a proximal end of the syringe, the seal configured to be pierced by a needle to obtain fluid communication between the medicament in the syringe and the needle.

[0023] The syringe holder according to the second aspect comprises a needle assembly securing feature at a proximal end of the syringe holder, wherein the needle assembly securing feature is configured for securing the needle assembly including the needle to the syringe holder after the cartridge is installed in the autoinjector.

[0024] The cassette according to the second aspect may further comprise one or more indexing ring release tabs movable relative to the indexing ring between at least two positions, the at least two positions comprising:

[0025] o an initial position (PraIN) in which the indexing ring is prevented from rotating from the first rotational position (R1) to the second rotational position (R2); and

[0026] a release position (PraR) in which the indexing ring can be rotated from the first rotational position (R1) to the second rotational position (R2);

[0027] Wherein when the cartridge is secured in the autoinjector, movement of the one or more release members of the autoinjector to a first release member position within the cartridge moves the one or more indexing ring release tabs from an initial position (PraIN) to a released position (PraR).

[0028] The cartridge according to the second aspect enables the use of an autoinjector that is initially designed and optimized to receive a cartridge system having a syringe with a pre-installed needle for delivering medication from the cartridge system, wherein the syringe requires the user to connect the needle to the syringe compartment at the user's end. This alleviates the flexibility of autoinjectors, which are typically limited by cartridges provided in a specific physical form. This reduces the production cost of reusable autoinjectors because modifications to the cartridge allow the same reusable syringe to support medication delivery processes using different cartridge types. For example, if a pre-installed needle is not present, the cartridge according to the second aspect ensures that the needle safety cover allows both the installation of the needle and the covering of the needle after medication delivery using the same autoinjector as used for medication delivery from a cartridge with a pre-installed needle. This cartridge avoids introducing any changes to the autoinjector. Modifying the software control process of an electronic reusable autoinjector is generally quite easy because it can be performed without affecting the mechanical structure of such a system. However, the typical application of alternative cartridges requires mechanical modifications to the autoinjector, which is avoided by this cartridge. Thus, with a cartridge as described above, the specific requirements and needs of delivering a medicament from a particular cartridge can be captured and addressed without modifying the reusable auto-injector. This reduces the cost of purchasing a complex and durable reusable auto-injector.

[0029] In a third aspect, the present invention also discloses a box for use in an automatic syringe for administering a medicament, wherein the box extends from a proximal end to a distal end in a longitudinal direction (L). The box includes a syringe holder configured to receive a syringe containing a medicament. The syringe may include a seal at the proximal end of the syringe that is configured to be pierced by a needle to obtain fluid communication between the needle and the medicament in the syringe. The syringe holder includes a needle assembly fixing component at the proximal end of the syringe holder, wherein the needle assembly fixing component is configured to fix the needle assembly including the needle to the syringe holder after the box is installed in the automatic syringe. The box also includes a needle mounting blocking system, wherein the proximal end of the needle mounting blocking system is configured to move between a plurality of longitudinal positions relative to the syringe holder. The plurality of longitudinal positions include at least:

[0030] o a locked position (PnsL), which prevents the seal from being pierced by a needle; and

[0031] o A needle assembly connection position (PnsC) in which the seal is allowed to be pierced by the needle.

[0032] Movement of the proximal end of the needle mounting blocking system is configured to be controlled by the auto-injector after the cartridge is secured in the auto-injector.

[0033] By "controlled by the auto-injector after the cartridge is secured in the auto-injector" is meant that movement of the needle installation blocking system is prevented until the auto-injector changes a portion of the configuration of the cartridge thereby allowing distal movement of the needle installation blocking system.

[0034] Therefore, by the box according to the third aspect, any premature contact between the injection needle and the medicament in the syringe compartment is prevented. Before the user has fixed the box in the auto-injector, it is impossible for the user to fix the needle to the syringe and thus make the injection needle contact with the medicament fluid. This prevents the user from connecting the needle assembly to the box for the purpose of preparing for the rapid injection at a later time point. By the box according to the third aspect, a kind of auto-injector can be used, which is initially designed and optimized for receiving a box system with a syringe, which has a pre-installed needle for delivering medicament from the box system, wherein the syringe requires the user to connect the injection needle to the syringe compartment at the user end. Therefore, the flexibility of the box that the auto-injector is usually limited to being provided in a specific physical form is alleviated. This reduces the production cost of the reusable auto-injector, because the modification of the box makes it possible for the same reusable syringe to support the medicament delivery process using different box types. For example, if there is no pre-installed needle, the box according to the first aspect and / or the second aspect ensures that the needle safety cover can allow the needle to be installed, and can also allow the needle to be covered after the drug delivery is carried out using the same automatic injector as that used for the drug delivery from the box with the pre-installed needle. The above-mentioned box avoids introducing any changes to the automatic injector. It is usually quite easy to change the software control process of the electronic reusable automatic injector because they can be carried out without affecting the mechanical structure of such systems. However, the application of an alternative box usually requires mechanical changes to the automatic injector, which is avoided by the above-mentioned box. Therefore, by the box as described above, the specific requirements and needs of delivering the drug from a specific box can be captured and processed without modifying the reusable automatic injector. This reduces the cost of purchasing complex and durable reusable automatic injectors.

[0035] A syringe configured to be received in a cassette according to the first aspect, the second aspect or the third aspect may comprise a syringe compartment containing the medicament.The compartment may be a single chamber compartment.

[0036] Alternatively, the syringe compartment may be a two-compartment compartment comprising a first sub-compartment housing a first medicament component and a second sub-compartment housing a second medicament component, wherein a second stopper separates the two sub-compartments. In one or more examples, the syringe compartment comprises:

[0037] a first subcompartment housing a first medicament component;

[0038] a second subcompartment housing a second pharmaceutical component;

[0039] a bypass region positioned between the first subcompartment and the second subcompartment;

[0040] • a first stopper positioned distally in the first subcompartment prior to use; and

[0041] • a second stopper positioned between the first subcompartment and the second subcompartment prior to use;

[0042] When the first stopper moves in the proximal direction, the first medicament component moves proximally, thereby causing the second stopper to move proximally, thereby allowing the first medicament component to enter the second sub-compartment through the bypass area, thereby mixing the first medicament component and the second medicament component.

[0043] The first medicament component and the medicament in the second sub-compartment may be mixed prior to medicament delivery by proximal movement of the second stopper.

[0044] Alternatively, the syringe two-chamber compartment may be designed to contain two liquid substances, which are then injected, for example, through the same injection needle.

[0045] In one or more examples, the needle assembly securing member secures the needle assembly to the proximal end of the syringe holder by a threaded connection, a press fit connection, a snap fit connection, a bayonet connection, or a combination thereof. Alternative connection options are also contemplated. The defined options are examples only.

[0046] The needle assembly connection position (PnsC) is typically distal to the locking position (PnsL).

[0047] In one or more examples, the needle assembly is pre-installed at the proximal end of the needle mounting barrier system prior to use, and fluid connection between the syringe and the needle is achieved by distal movement of the needle assembly and the needle mounting barrier system relative to the syringe, which may be combined with rotational movement of the needle assembly relative to the syringe. Alternatively, or in combination, the needle assembly can be pre-installed at the first needle safety cover prior to use, and fluid connection between the syringe and the needle is achieved by distal movement of the needle assembly, the second needle safety cover, and the first needle safety cover relative to the syringe, which may be combined with rotational movement of the needle assembly relative to the syringe. Pre-installing the needle assembly at the proximal end of the needle mounting barrier system and / or the first needle safety cover means that the needle assembly can rest and be supported on the proximal end of the needle mounting barrier system and / or the first needle safety cover. This allows the user to have a pre-set system in which they do not need to keep track of the position of the needle assembly. Instead, the needle assembly and cartridge can be stored together as a unit, wherein needle penetration of the seal is still prevented until the cartridge and needle assembly system are secured in the autoinjector.

[0048] In one or more examples, the proximal end of the needle mount blocking system is configured as a needle safety cap that covers the needle after medicament delivery. Thus, the needle mount blocking system has a dual function.

[0049] In one or more examples, the needle mounting blocking system includes:

[0050] ●First needle safety cover;

[0051] a second needle safety cover, wherein the first needle safety cover is displaceable relative to the second needle safety cover in a longitudinal direction; and

[0052] One or more release arms, wherein the one or more release arms are movable between at least two positions relative to the syringe holder, the at least two positions comprising:

[0053] ○ Initial position (PraIN), in which the first needle safety cover and the second

[0054] The needle safety cover is separated by at most a first separation distance; and

[0055] o A release position (PraR), in which the first needle safety cover and the second needle safety cover are allowed to move relative to each other to a second separation distance greater than the first separation distance.

[0056] The one or more release arms can be part of the second needle safety cover or the first needle safety cover. The one or more release arms can be replaced by a release finger, a release protrusion, or any other release device that controls the relative movement of the first and second needle safety covers between the initial position and the released position. The second separation distance can be the extended position. The relative movement between the two needle safety cover components can be considered a telescopic movement.

[0057] In one or more examples, the proximal end of the needle installation blocking system is included in the second needle safety cover. Configurations are also conceivable in which the first needle safety cover includes the proximal end of the needle installation blocking system. As long as one of the parts includes this function, it is generally not critical which of the two cover components prevents the installation of the needle assembly.

[0058] In one or more examples, after the cartridge is secured in the autoinjector, the second needle safety cover is configured to be longitudinally unlocked, whereby the second needle safety cover can be moved distally relative to the syringe holder, thereby moving the proximal end of the needle installation blocking system and / or the second needle safety cover to a needle assembly connection position (PnsC), thereby allowing the needle assembly to be secured to the syringe holder. Unlocking the needle installation blocking system and / or the second needle safety cover allows the needle assembly to be installed in the cartridge.

[0059] In one or more examples, after securing the cartridge in the autoinjector, the first needle safety cover and the one or more cover springs are configured for longitudinal unlocking, whereby the first needle safety cover and the one or more cover springs are movable in a distal direction relative to the syringe holder.

[0060] In one or more examples, the cartridge (e.g., the needle installation blocking system) further comprises one or more cover springs biased between the first and second needle safety covers. The cover springs may be replaced by a spring system within the auto-injector that acts on the first needle safety cover relative to the second needle safety cover after the cartridge is installed in the auto-injector. Thus, after relative release of the two needle safety cover components, movement from the initial position (PraIN) to the released position (PraR) may be assisted by the one or more cover springs in the cartridge or by the spring system within the auto-injector.

[0061] In one or more examples, the second needle safety cover is longitudinally locked relative to the syringe holder when the proximal end of the needle mounting barrier system is in a locked position (PnsL) that prevents the seal from being pierced by a needle. The second needle safety cover thereby prevents the seal from being pierced by a needle. In configurations where the first needle safety cover includes the proximal end of the needle mounting barrier system, the first needle safety cover will typically be a cover component that is longitudinally locked in the locked position (PnsL) relative to the syringe holder.

[0062] In one or more examples, the plurality of longitudinal positions between which the proximal end of the needle mount blocking system can move further include a medication delivery position (PnsD) in which the needle is exposed, and a final locking position (PnsFL) in which further longitudinal movement of the needle mount blocking system is prevented, wherein the final locking position (PnsFL) is proximal to the medication delivery position (PnsD). The extended locking position of the needle mount blocking system can allow the needle mount blocking system to also function as a needle shield system, wherein the injection needle can be blocked after medication delivery.

[0063] In one or more examples, the plurality of longitudinal positions between which the proximal end of the needle mount blocking system is movable further includes a ready-to-use position (PnsR), in which the proximal end of the needle mount blocking system covers the needle, wherein the needle mount blocking system is in the ready-to-use position (PnsR) before being moved to the medication delivery position (PnsD). This prevents a user and / or a practitioner delivering medication to a patient from accidentally coming into contact with the needle before medication delivery begins.

[0064] In one or more examples, the cassette according to the first aspect further comprises an indexing ring rotatable relative to the first needle safety cover between a plurality of rotational positions, the plurality of rotational positions comprising at least:

[0065] a first rotational position (R1) in which the second needle safety cover is prevented from distal movement; and

[0066] a second rotational position (R2) in which the second needle safety cover is able to move longitudinally;

[0067] wherein when the cartridge is secured in the auto-injector, movement of one or more release members in the auto-injector causes the indexing ring to rotate. The indexing ring allows for easy unlocking of the cartridge components, wherein the rotation of the indexing ring is controlled by longitudinal movement of the one or more release members of the auto-injector into / out of the cartridge.

[0068] Likewise, in one or more examples, the cartridge according to the third aspect further comprises an indexing ring rotatable relative to the needle mounting blocking system between a plurality of rotational positions, the plurality of rotational positions comprising at least:

[0069] a first rotational position (R1) in which the needle mounting blocking system is prevented from distal movement; and

[0070] a second rotational position (R2) in which the needle mounting blocking system is movable between a locked position (PnsL) and a needle assembly connected position (PnsC);

[0071] wherein when the cartridge is secured in the autoinjector, rotation of the indexing ring is controlled by movement of one or more release members in the autoinjector. The indexing ring can facilitate unlocking of the needle installation blocking system, wherein rotation of the indexing ring is controlled by longitudinal movement of one or more release members of the autoinjector into / out of the cartridge.

[0072] The indexing ring according to all aspects of the cassette may include a track extending from a first corner to a second corner of a surface area of ​​the indexing ring.

[0073] In one or more examples, an indexing ring according to any of the aspects is configured to rotate from a first rotational position (R1) to a second rotational position (R2) when the cartridge is inserted into the autoinjector and one or more release members included in the autoinjector travel proximally within the track. The introduction of an inclined surface in the track allows for easy rotation of the indexing ring. Typically, the indexing ring is prevented from moving in a longitudinal direction relative to the syringe holder.

[0074] In one or more examples, the track extends from the first corner toward the second corner in an angled direction, wherein the angled direction is between 20 and 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as about 45 degrees relative to the longitudinal direction of the box. The track can be a track with the same angled direction angle along the entire track. Alternatively, the angled direction does not need to extend over the entire track portion or have the same angle over the entire track portion. Instead, it can have separate track portions with different angled directions.

[0075] In one or more examples, the track includes a first track segment and a second track segment, wherein:

[0076] o a first track segment extending in a first angular direction from a first corner toward a first midpoint;

[0077] o The second track segment extends in a second angular direction along the longitudinal direction of the cassette from the first midpoint to the second midpoint.

[0078] The first angled direction may be between 20 and 70 degrees relative to the longitudinal direction of the box, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees.

[0079] The second angled direction may be between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box.

[0080] This creates two track sections, wherein the one or more release members entering and moving proximally along the first track section rotates the indexing ring from the first rotational position R1 to the second rotational position R2. When the one or more release members advance distally, the indexing ring rotates back to the first rotational position. When the one or more release members are in and along the second track section, if the second angular direction is approximately 0 degrees, the indexing ring does not rotate further.

[0081] In one or more examples, the track further includes a third track segment, wherein the third track segment extends from the second midpoint toward the second corner in a third angular direction. The third angular direction may be between 20 and 70 degrees relative to the longitudinal direction of the cassette, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees. Including the third track segment allows the indexing ring to be further rotated from the second rotational position to the third rotational position. This provides the opportunity to further release and / or secure the cassette component to the indexing ring.

[0082] In one or more examples, the cartridge further comprises one or more indexing ring release tabs movable relative to the indexing ring, wherein when the cartridge is secured in the autoinjector, movement of the autoinjector's one or more release members to a first release member position within the cartridge moves the one or more indexing ring release tabs from an initial position (PraIN) to a released position (PraR). The one or more indexing ring release tabs may be part of the syringe holder.

[0083] In one or more examples, the one or more indexing ring release tabs include a protruding surface that engages a blocking surface on the indexing ring in an initial position (PraIN), thereby preventing the indexing ring from rotating from the first rotational position (R1) to the second rotational position (R2). The one or more indexing ring release tabs can be configured to deflect radially inwardly by proximal movement of the one or more release members when the cartridge is secured in the autoinjector. When the one or more indexing ring release tabs deflect radially inwardly, the protruding surface generally no longer engages the blocking surface on the indexing ring, thereby enabling the indexing ring to rotate from the first rotational position (R1) to the second rotational position (R2).

[0084] In one or more examples, the indexing ring is rotatable from a first rotational position ( R1 ) to a second rotational position ( R2 ) by distal movement of the needle safety cover.

[0085] In one or more examples, the indexing ring is configured to rotate from the first rotational position (R1) to the second rotational position (R2) upon distal movement of the first needle safety cover when the protruding surface no longer engages the blocking surface on the indexing ring.

[0086] In one or more examples, the indexing ring is configured to rotate from a first rotational position (R1) to a second rotational position (R2) by a second indexing ring engaging finger on a second needle safety cover traveling within a first secondary track segment on the indexing ring.

[0087] In one or more examples, when the one or more release members are in the first release member position within the cartridge, the indexing ring is prevented from further rotation from the second rotational position (R2) to the third rotational position (R3) by the one or more release members engaging a first track in the indexing ring.

[0088] In one or more examples, the indexing ring is rotatable from a second rotational position (R2) to a third rotational position (R3) as one or more release members of the autoinjector are moved proximally from a first release member position within the cartridge to a second release member position within the cartridge.

[0089] In one or more examples, the indexing ring is capable of rotating from a second rotational position (R2) to a third rotational position (R3) as one or more release members of the automatic injector move further proximally from a first release member position within the cartridge to a second release member position within the cartridge, the second release member position being proximal to the first release member position.

[0090] In one or more examples, the indexing ring is configured to rotate from the second rotational position (R2) to a third second rotational position (R3) by distal movement of the first needle safety cover after one or more release members of the automatic injector move proximally from a first release member position within the cartridge to a second release member position within the cartridge.

[0091] In one or more examples, the indexing ring is configured to rotate from the second rotational position (R2) to a third second rotational position (R3) by a second indexing ring engaging finger on the second needle safety cover traveling within a third secondary track segment on the indexing ring.

[0092] In one or more examples, when the indexing ring is in the third second rotational position (R3), the second indexing ring engaging finger no longer abuts at least one of the one or more release arms on the indexing ring, thereby allowing the first needle safety cover and the second needle safety cover to move proximally relative to the indexing ring to a final locked position.

[0093] In one or more examples, when the one or more release members are in the first release member position within the cartridge, the indexing ring is prevented from further rotation from the second rotational position (R2) to the third rotational position (R3) by the one or more release members engaging a first track in the indexing ring.

[0094] In one or more examples, if a dual chamber syringe is used, the indexing ring is in the second rotational position (R2) when the first and second medicament components are mixed.

[0095] The one or more release arms may be separate items. Alternatively, in one or more examples, the release arm is part of the indexing ring. The release arm may be positioned at the proximal end of the indexing ring.

[0096] In one or more examples, the first needle safety cover includes a first indexing ring engaging finger and the second needle safety cover includes a second indexing ring engaging finger. When the indexing ring is in a first rotational position (R1), the first indexing ring engaging finger and the second indexing ring engaging finger can abut at least one of the one or more release arms on the indexing ring, thereby preventing proximal movement of the first and second needle safety covers relative to the indexing ring.

[0097] When the indexing ring is in the second rotational position (R2), the first indexing ring engagement finger may no longer be adjacent to at least one of the one or more release arms on the indexing ring, whereby the one or more cover springs are configured to move the first needle safety cover proximally relative to the second needle safety cover, thereby moving the first needle safety cover to a locked cover position, in which further relative longitudinal movement between the first needle safety cover and the second needle safety cover is prevented.

[0098] Typically, there are two indexing ring engaging fingers on both the first and second needle safety covers. They are symmetrically positioned on opposite sides.

[0099] In one or more examples, the first needle safety cover and the second needle safety cover include a first locking pair and a second locking pair, wherein in the locked cover position, the first locking pair prevents proximal movement of the first needle safety cover relative to the second needle safety cover, and the second locking pair prevents distal movement of the first needle safety cover relative to the second needle safety cover. Proximal locking can be achieved by the first locking pair, which constitutes a proximal first needle safety cover interface on the first needle safety cover and a distal second needle safety cover locking tab on the second needle safety cover. Distal locking can be achieved by the second locking pair, which constitutes a distal first needle safety cover locking surface on the first needle safety cover and a proximal second needle safety cover locking tab on the second needle safety cover. The surfaces / components on the first needle safety cover and the second needle safety cover are adjacent to each other to form the locking pair.

[0100] In one or more examples, the indexing ring includes a second track extending from a first secondary corner to a second secondary corner of a surface area of ​​the indexing ring, wherein the indexing ring is configured to rotate from a first rotational position (R1) to a second rotational position (R2) by distal movement of the needle safety cover, whereby at least one protrusion on the needle safety cover travels within the second track, thereby causing the indexing ring to rotate.

[0101] In one or more examples, the indexing ring includes a second track extending from a first secondary corner to a second secondary corner of a surface area of ​​the indexing ring, wherein the indexing ring is configured to rotate from the first rotational position (R1) to the second rotational position (R2) by distal movement of the second needle safety cover, whereby a second indexing ring engaging finger on the second needle safety cover travels within the second track, thereby rotating the indexing ring.

[0102] In one or more examples, the second track includes a first secondary track segment and a second secondary track segment, wherein:

[0103] o a first secondary track segment extending in a first secondary angular direction from a first secondary corner toward a first secondary midpoint;

[0104] o The second secondary track segment extends from the first secondary midpoint to the second secondary midpoint in a second secondary angular direction along the longitudinal direction of the box.

[0105] The first pair of angled directions may be between 20 and 70 degrees relative to the longitudinal direction of the box, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees.

[0106] The second pair of angled directions may be between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box.

[0107] In one or more examples, the second track further comprises a third secondary track segment, wherein the third secondary track segment extends from the second secondary midpoint toward the second secondary corner in a third secondary angular direction. The third secondary angular direction can be between 20 and 70 degrees relative to the longitudinal direction of the box, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees.

[0108] In one or more examples, the second track further includes a fourth secondary track segment. The fourth secondary track segment generally extends distally from the second secondary corner. The fourth secondary track segment may have a platform track segment having a fourth angled orientation relative to the longitudinal direction of the cassette between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees.

[0109] In one or more examples, the indexing ring is configured to rotate from a first rotational position (R1) to a second rotational position (R2) when the cartridge is inserted into the autoinjector and one or more release members included in the autoinjector travel proximally within the track.

[0110] In one or more examples, the indexing ring is rotatable from a second rotational position (R2) to a third rotational position (R3) as one or more release members of the autoinjector are moved proximally from a first release member position within the cartridge to a second release member position within the cartridge.

[0111] In one or more examples, the indexing ring is configured to rotate from the second rotational position (R2) to a third second rotational position (R3) by distal movement of the first needle safety cover after one or more release members of the automatic injector move proximally from a first release member position within the cartridge to a second release member position within the cartridge.

[0112] In one or more examples, when the indexing ring is in the third second rotational position (R3), the second indexing ring engaging finger no longer abuts at least one of the one or more release arms on the indexing ring, thereby allowing the first needle safety cover and the second needle safety cover to move proximally relative to the indexing ring to a final locked position.

[0113] In one or more examples, in the initial position (PraIN), the first needle safety cover is prevented from moving proximally relative to the second needle safety cover. Similarly, in the released position (PraR), the first needle safety cover can be allowed to move proximally relative to the second needle safety cover. The proximal movement of the first needle safety cover can allow the needle mounting blocking system / needle safety cover component to be telescopically extended. When the first needle safety cover is positioned proximally of the second needle safety cover before telescopic extension, the telescopic extension by moving the first needle safety cover proximally relative to the second needle safety cover will generally increase the distance between the proximal end of the first needle safety cover and the proximal end of the second needle safety cover.

[0114] Before the cassette is secured in the autoinjector, the first and second needle safety covers may be allowed to move towards each other by compression of one or more cover springs. This may facilitate mounting of the needle assembly to the cassette.

[0115] In one or more examples, the first needle safety cover includes one or more cover locking tabs that lock the first needle safety cover in a final locked position by preventing distal movement of the first needle safety cover relative to the cartridge housing.

[0116] In one or more examples, the second needle safety cover includes at least one flexible arm, the first needle safety cover includes a first locking tab, and the one or more release arms each include a protruding surface release component, wherein the protruding surface release component limits proximal movement of the first needle safety cover relative to the second needle safety cover in an initial position (PraIN) by preventing the at least one flexible arm from flexing when abutting the first locking tab. In this manner, telescopic movement of both needle safety cover components is limited by the one or more release arms.

[0117] In one or more examples, the second needle safety cover, the first needle safety cover, and the one or more release arms are configured to move distally relative to the syringe holder when the needle assembly is secured to the syringe holder. The needle safety cover component / needle installation blocking system can be configured to be pushed distally when the user secures the needle assembly to the cartridge.

[0118] In one or more examples, when the needle assembly is secured to the syringe holder, each of the second needle safety cover, the first needle safety cover, and the one or more release arms move distally relative to the syringe holder by a different distance. When the second needle safety cover, the first needle safety cover, and the one or more release arms are pushed distally when the needle assembly is secured to the cassette, each of them can perform such movement relative to each other. Alternatively, two of the components can move longitudinally the same distance.

[0119] In one or more examples, the needle assembly further comprises a removable needle cap that covers and protects the needle prior to use, wherein after the needle assembly is secured to the syringe holder and the needle cap is removed, the one or more cover springs are adapted to push the first needle safety cover in a proximal direction relative to the second needle safety cover, whereby the first needle safety cover covers the needle in the ready-to-use position (PnsR). Thus, the proximal end of the needle mounting blocking system is in the ready-to-use position (PnsR). As described above, the one or more cover springs may alternatively be replaced by a spring system within the autoinjector that acts on the first needle safety cover relative to the second needle safety cover after the cartridge is mounted in the autoinjector.

[0120] In one or more examples, after securing the needle assembly to the syringe holder, the one or more release arms are locked relative to the syringe holder.

[0121] In one or more examples, when the one or more release arms are in the release position (PraR) after the needle assembly is secured to the syringe holder and the needle cap is removed, the second needle safety cover is adapted to be moved proximally by the autoinjector while the one or more release arms are locked relative to the syringe holder. Proximal movement of the second needle safety cover relative to the one or more release arms can push the first needle safety cover and the second needle safety cover to a position where telescopic movement between the second needle safety cover components is possible. Proximal movement of the second needle safety cover can cause the first needle safety cover to follow the movement. Alternatively, proximal movement of the first needle safety cover can cause the second needle shield to follow the movement.

[0122] In one or more examples, when the one or more release arms are in the released position (PraR) after securing the needle assembly to the syringe holder and removing the needle cap, the one or more cap springs are adapted to push the first needle safety cover in a proximal direction relative to the second needle safety cover, thereby causing the at least one flexible arm to move proximally and past the protruding surface release component into a position where the at least one flexible arm is deflected, thereby allowing the first locking tab of the first needle safety cover to pass through the at least one flexible arm, thereby pushing the first needle safety cover to the extended position relative to the second needle safety cover using the one or more cap springs. In the above examples, the proximal movement of the first needle safety cover causes the second needle safety cover to follow.

[0123] In one or more examples, when the cartridge is in the ready-for-use position (PnsR), the one or more locking arms are in a released position (PraR), and the needle safety cover component / needle mounting block system is in a locked cover position in which further relative longitudinal movement of the first needle safety cover relative to the second needle safety cover is prevented. The locked position of the first needle safety cover relative to the second needle safety cover does not prevent the two components from moving together as a combined needle safety cover.

[0124] In one or more examples, the first needle safety cover includes a second locking tab positioned distally of the first locking tab, and the second needle safety cover includes a stop surface positioned proximally of the flexible arm, wherein in the locked cover position, the second locking tab abuts the flexible arm, thereby preventing distal movement of the first needle safety cover relative to the second needle safety cover, and the first locking tab abuts the stop surface, thereby preventing proximal movement of the first needle safety cover relative to the second needle safety cover. Thus, the first needle safety cover is locked relative to the second needle safety cover.

[0125] In one or more examples, the first needle safety cover is movable relative to the syringe holder between a plurality of longitudinal positions, the plurality of longitudinal positions comprising:

[0126] ●Ready to use position (PnsR);

[0127] a drug delivery site (PnsD) at which the needle is exposed, wherein the drug delivery site (PnsD) is distal to the ready-to-use site (PnsR);

[0128] • A final locking position (PnsFL) in which further longitudinal movement of the first needle safety cover is prevented, wherein the final locking position (PnsFL) is proximal to the medicament delivery position (PnsD).

[0129] This ready-to-use position prevents the user and / or the practitioner delivering the medicament to the patient from accidentally contacting the needle before starting medicament delivery.In the final locked position, the injection needle can be covered after medicament delivery, thereby preventing accidental contact with the needle after medicament delivery.

[0130] In one or more examples, a first needle safety cover covers the needle in a ready to use position (PnsR).

[0131] In one or more examples, the final locked position (PnsFL) is proximal to the ready-to-use position (PnsR).

[0132] In one or more examples, after the medicament is delivered, distal movement of the one or more release members rotates the indexing ring back to the first rotational position (R1), thereby longitudinally locking the proximal end of the needle mounting block system and / or the first needle safety cover in the final locked position (PnsFL). Thus, the indexing ring can help secure the needle mounting block system and / or the first needle safety cover in the final locked position after the medicament is delivered.

[0133] In one or more examples, the second needle safety cover also functions as a needle installation blocking system configured to move between the following positions:

[0134] a locked position (PnsL) which prevents the seal from being pierced by a needle before the cartridge is secured in the autoinjector; and

[0135] - A needle assembly connection position (PnsC) which allows the seal to be pierced by a needle after the cartridge is secured in the autoinjector.

[0136] The movement of the second needle safety cover can be configured to be controlled by the auto-injector after the cartridge is secured in the auto-injector. Thus, any premature contact between the injection needle and the medicament in the syringe compartment is prevented. Before the user has secured the cartridge in the auto-injector, it is impossible for the user to secure the needle to the syringe and thereby bring the injection needle into contact with the medicament fluid. This prevents the user from attaching the needle assembly to the cartridge for the purpose of preparing for a rapid injection at a later point in time, thereby potentially piercing the seal.

[0137] In one or more examples, the needle assembly includes a removable needle cap, wherein removal of the needle cap allows the proximal end of the needle mounting barrier system to move proximally when the proximal end of the needle mounting barrier system is in the medicament delivery position (PnsD).

[0138] In one or more examples, the plurality of longitudinal positions between which the proximal end of the needle mounting block system is movable further comprises:

[0139] A drug delivery site (PnsD) where the needle is exposed;

[0140] a final locking position (PnsFL) in which further longitudinal movement of the needle mounting barrier system is prevented,

[0141] The drug delivery position (PnsD) and the final locking position (PnsFL) are in the same longitudinal position. Therefore, when locked after use, the needle mounting blocking system remains in the drug delivery position.

[0142] In one or more examples, after delivery of the medicament, distal movement of one or more release members in the automatic injector is configured to rotate the indexing ring back to the first rotational position (R1), whereby the proximal end of the needle mounting blocking system is longitudinally locked in the final locking position (PnsFL).

[0143] In one or more examples, when the indexing ring is in the second rotational position (R2), one or more cover springs cause the first needle safety cover to move proximally relative to the second needle safety cover to a locked cover position, in which further relative longitudinal movement between the first needle safety cover and the second needle safety cover is prevented by one or more locking devices.

[0144] In one or more examples, the one or more locking devices include a first locking pair, wherein the first needle safety cover and the second needle safety cover include the first locking pair that prevents proximal movement of the first needle safety cover relative to the second needle safety cover.

[0145] In one or more examples, the one or more locking devices include a second locking pair, wherein the first needle safety cover and the second needle safety cover include the second locking pair that prevents distal movement of the first needle safety cover relative to the second needle safety cover.

[0146] In one or more examples, the needle safety cover is configured to move between the following positions:

[0147] a locked position (PnsL) which prevents the seal from being pierced by a needle before the cartridge is secured in the autoinjector; and

[0148] - A needle assembly connection position (PnsC) which allows the seal to be pierced by a needle after the cartridge is secured in the autoinjector.

[0149] When the indexing ring is in the first rotational position (R1), the needle safety cover may be in a locked position (PnsL), and when the indexing ring is in the second rotational position (R2), the needle safety cover may be capable of moving to a needle assembly connection position (PnsC) by distal movement of the needle safety cover.

[0150] In one or more examples, the needle safety cover according to the third aspect includes:

[0151] Needle safety cover; and

[0152] A second needle safety cover, wherein the first needle safety cover is displaceable in a longitudinal direction relative to the second needle safety cover.

[0153] In the initial position (PraIN), the first needle safety cover and the second needle safety cover can be separated by at most a first separation distance. In the release position (PraR), the first needle safety cover and the second needle safety cover can be allowed to move relative to each other to a second separation distance greater than the first separation distance.

[0154] In one or more examples, a cartridge according to any of the aspects having a two-part safety device further comprises one or more cover springs biased between a first needle safety cover and a second needle safety cover. The first needle safety cover may include a first indexing ring engaging finger, and the second needle safety cover may include a second indexing ring engaging finger. When the indexing ring is in a first rotational position (R1), the first indexing ring engaging finger and the second indexing ring engaging finger on the second needle safety cover typically abut at least one of the one or more release arms on the indexing ring, thereby preventing proximal movement of the first and second needle safety covers relative to the indexing ring. When the indexing ring is in a second rotational position (R2), the first indexing ring engaging finger typically no longer abuts at least one of the one or more release arms on the indexing ring, thereby preventing the first and second needle safety covers from moving proximally relative to the second needle safety cover, thereby moving the first needle safety cover to a locked cover position, in which further relative longitudinal movement between the first and second needle safety covers is prevented.

[0155] In one or more examples, the first needle safety cover and the second needle safety cover include a first locking pair and a second locking pair, wherein in the locked cover position, the first locking pair prevents the first needle safety cover from moving proximally relative to the second needle safety cover, and the second locking pair prevents the first needle safety cover from moving distally relative to the second needle safety cover.

[0156] In one or more examples, the first needle safety cover includes one or more housing locking components that lock the first needle safety cover in a final locked position by preventing distal movement of the first needle safety cover relative to the cartridge housing.

[0157] In one or more examples, the first needle safety cover includes one or more housing locking components that lock the first needle safety cover in a final locked position by preventing distal movement of the first needle safety cover relative to the cartridge housing.

[0158] In one or more examples, the one or more release arms are separate components that do not form part of the indexing ring, the second needle safety cover, and the first needle safety cover.

[0159] In a fourth aspect, the present invention also discloses a system for use in an autoinjector for administering a medicament. The system includes a cartridge according to the first, second, or third aspects and a syringe containing the medicament. The syringe may include a seal at a proximal end of the syringe, the seal configured to be pierced by a distal end of a needle to establish fluid communication between the medicament in the syringe and the needle. Before the cartridge is secured in the autoinjector, a first needle safety cap prevents the distal end of the needle from piercing the seal. The proximal end of the needle is configured to pierce the seal of the syringe, and the proximal end of the needle is configured to pierce an injection site.

[0160] The system may also include a needle assembly including a needle, a needle assembly adapter for securing the needle assembly to the syringe holder, and a removable needle cap that covers and protects the needle.

[0161] The syringe may include a syringe compartment for accommodating the medicaments. The compartment may be a single-chamber compartment. Alternatively, the syringe compartment may be a two-chamber compartment comprising a first sub-compartment for accommodating a first medicament component and a second sub-compartment for accommodating a second medicament component, wherein a second stopper separates the two sub-compartments. The medicaments in the first medicament component and the second sub-compartment may be mixed prior to medicament delivery by proximal movement of the second stopper.

[0162] The syringe can be a 1 mL to 3 mL syringe, such as a 1 mL, 2.25 mL, or 3 mL syringe. Examples include a 3 mL liquid single-chamber cartridge and a 1 mL dual-chamber cartridge. When referring to a 1 mL dual-chamber cartridge, 1 mL can refer to the resulting reconstituted liquid dose to be injected, i.e., the total amount of the mixed dose. The syringe can also have a sleeve at the distal end of the syringe to facilitate installation in a syringe holder.

[0163] In one or more examples, the system further includes an autoinjector, wherein the autoinjector is configured to receive the cartridge.

[0164] The autoinjector may comprise one or more release members configured to move into the cartridge when the cartridge has been received in the autoinjector.

[0165] In one or more examples, the needle assembly further includes a needle assembly shield configured to be in a plurality of positions, the plurality of positions including:

[0166] an initial delivery position in which the needle assembly shield of the needle assembly covers the needle;

[0167] A drug delivery site at which the needle is exposed;

[0168] • A final locked position in which the needle assembly shield of the needle assembly covers the needle.

[0169] In a fifth aspect, an autoinjector for administering a medicament is disclosed herein, configured to receive any of the cartridges according to the first, second, or third aspects, and / or configured to receive the system according to the fourth aspect, without requiring modification. This allows the autoinjector to be used with different cartridge types without requiring modification. Any modifications required based on medication type requirements, differences in needle assembly design, etc., are included as modifications to the respective cartridges. Alternatively, minor modifications to, for example, the autoinjector electronics are contemplated.

[0170] In a sixth aspect, disclosed herein is a system comprising an autoinjector for administering a medicament and a cartridge according to the first, second, or third aspects. The system may further comprise a needle assembly comprising a needle, a needle assembly adapter for securing the needle assembly to a syringe holder, and a removable needle cap that covers and protects the needle, wherein a needle installation blocking system prevents a distal end of the needle from piercing a seal before the cartridge is secured in the autoinjector. The distal end of the needle is configured to penetrate a septum. The proximal end of the needle is configured to penetrate an injection site during medicament delivery. BRIEF DESCRIPTION OF THE DRAWINGS

[0171] Various examples are described below with reference to the accompanying drawings. Throughout the text, similar reference numerals refer to similar elements. Therefore, the same elements will not be described in detail with reference to the description of each figure. It should also be noted that the drawings are intended only to facilitate the description of the examples. They are not intended to be an exhaustive description of the claimed invention or to limit the scope of the claimed invention. In addition, the illustrated examples do not need to have all the aspects or advantages shown. An aspect or advantage described in conjunction with a particular example is not necessarily limited to that example and may be practiced in any other example even if not shown or explicitly described as such.

[0172] Figure 1 An exploded view of the different components of a first example of a cartridge is shown.

[0173] Figure 2A -I shows the individual parts of the first box.

[0174] Figure 3 AL shows the first cartridge in a partially cutaway perspective view during installation of the needle assembly and medicament delivery.

[0175] Figure 4 AL shows the first cartridge in cross-section during installation of the needle assembly and medicament delivery.

[0176] Figure 6 AH shows the second cartridge during installation of the needle assembly and during medicament delivery.

[0177] Figure 7 Shown Figure 6 Exploded views of the different parts of the second example of the cartridge shown in AH.

[0178] Figure 8 AF show the third cassette before connection to the needle assembly, during connection to the needle assembly, and after removal of the needle assembly.

[0179] Figure 9 AH shows the third cartridge during installation of the needle assembly and during medicament delivery.

[0180] Figure 10A -C shows a dual chamber syringe for use with any of the illustrated examples of cassettes.

[0181] Figure 11 An exploded view of the different components of a fourth example of a cartridge is shown.

[0182] Figure 12A -H shows a separate portion of the fourth first box.

[0183] Figure 13 AK shows the fourth cartridge in cross-section during installation of the needle assembly and medicament delivery.

[0184] Figure 14A -G shows a close-up of the interaction between the first needle safety cover, the second needle safety cover, the indexing ring and the syringe holder during the process of installing the needle assembly to the syringe holder.

[0185] Figure 15A -B shows an autoinjector configured to receive a cassette according to the first example or the second example, wherein Figure 15A The assembled syringe is shown, and Figure 15B A view of the surfaces in the autoinjector that come into contact with the cartridge is shown.

[0186] Figure 16 Shown Figure 15A Exploded view of the auto-injector. DETAILED DESCRIPTION

[0187] Now, the following will more fully describe the exemplary embodiments with reference to the accompanying drawings. In this regard, this example can have different forms and should not be construed as being limited to the specific embodiments set forth herein. Therefore, the following examples are described only with reference to the accompanying drawings to explain various aspects. As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items. In the aforementioned element list, a statement such as "at least one of ... " modifies the entire element list without modifying the individual elements in the list.

[0188] In the accompanying drawings, for clarity and ease of description, the thickness of multiple layers and regions is shown in an amplified manner. When a layer, region, element or plate is referred to as "being located on another layer, region, element or plate", it may be directly located on the other layer, region, element or plate, or an intermediate layer, region, element or plate may be present between them. On the contrary, when a layer, region, element or plate is referred to as "being directly located on another layer, region, element or plate", there is no intermediate layer, region, element or plate between them. In addition, when a layer, region, element or plate is referred to as "being located below another layer, region, element or plate", it may be directly located below other layers, region, element or plate, or an intermediate layer, region, element or plate may be present between them. On the contrary, when a layer, region, element or plate is referred to as "being directly located below another layer, region, element or plate", there is no intermediate layer, region, element or plate between them.

[0189] For ease of description, spatially relative terms such as "lower" or "bottom" and "upper" or "top," "below," "beneath," "lesser," "above," and the like may be used herein to describe the relationship between one element or component and another element or component as shown in the accompanying drawings. It should be understood that in addition to the orientation shown in the accompanying drawings, spatially relative terms may be intended to encompass different orientations of the device in use or operation. For example, if the device shown in the accompanying drawings is turned over, an element described as being on the "lower" side of another element or "below" or "beneath" another element would then be oriented to be on the "upper" side of the other element or "above" another element. Thus, depending on the particular orientation of the accompanying drawings, the illustrative terms "below" or "beneath" may include both "lower" and "upper" orientation positions. Similarly, if the device in one of the figures is turned over, an element described as being "below" or "beneath" another element would be oriented "above" the other element. Thus, the exemplary terms "below" or "beneath" may encompass both above and below orientations, and thus spatially relative terms may be interpreted differently depending on the orientation.

[0190] Throughout the specification, when an element is referred to as being “connected” to another element, the element is “directly connected” to the other element or “electrically connected” to the other element with one or more intervening elements interposed therebetween.

[0191] The terms used herein are only used for the purpose of describing specific examples and are not intended to be limiting. As used herein, unless the context clearly indicates otherwise, the singular forms "a", "an" and "the" are also intended to include the plural forms. "At least one" should not be understood as limiting "one" or "an". It should be understood that when used in this specification, the terms "comprise" and / or "include" specify the presence of the described features, integers, steps, operations, elements and / or parts, but do not exclude the presence or increase of one or more other features, integers, steps, operations, elements, parts and / or groups thereof.

[0192] It should be understood that although the terms "first," "second," "third," etc. may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. Thus, without departing from the teachings of this document, the "first element" discussed below may be referred to as the "second element" or the "third element," and the "second element" and the "third element" may be named similarly.

[0193] As used herein, "about" or "approximately" is inclusive of the specified value and means within an acceptable range of deviation from the specified value as determined by one of ordinary skill in the art, taking into account the measurement in question and the errors associated with the measurement of the particular quantity (i.e., the limitations of the measurement system). For example, "about" can mean within one or more standard deviations, or within ±30%, ±20%, ±10%, ±5% of the specified value.

[0194] Unless otherwise defined, all terms used herein (including technical and scientific terms) have the same meaning as commonly understood by those skilled in the art to which the present invention belongs. It should also be understood that, unless explicitly defined as such in this specification, terms (such as those defined in general dictionaries) should be interpreted as having a meaning consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense.

[0195] Exemplary examples are described herein with reference to cross-sectional views of schematic diagrams that are idealized examples, wherein the same reference numerals refer to the same elements throughout the specification. Therefore, variations in the illustrated shapes due to, for example, manufacturing techniques and / or tolerances are to be expected. Therefore, the examples described herein should not be interpreted as being limited to the specific shapes of the regions as shown herein, but will include deviations in shapes caused, for example, by manufacturing. For example, a region shown or described as flat may have rough and / or nonlinear features. In addition, the sharp corners shown may be rounded. Therefore, the regions shown in the figures are schematic in nature, and their shapes are not intended to illustrate the precise shape of the regions and are not intended to limit the scope of the present claims. Some parts that are not associated with the description may not be provided in order to specifically describe the exemplary examples of the present disclosure.

[0196] The proximal end / proximal surface means the end / surface portion pointing towards the needle, i.e. the end of the cartridge which is closest to the injection site during medicament delivery. The distal end / distal surface means the end / surface portion pointing in the direction away from the needle, i.e. opposite to the end of the cartridge which is closest to the injection site during medicament delivery.

[0197] Figure 1 An exploded view of the different parts of the first example of the cartridge 100 is shown, however Figure 2A -I shows the Figure 1 , which is a separate part of the box shown in the figure, which is enlarged to obtain a clearer view as a separate part. Box 100 includes a syringe holder 300 for receiving syringe 200, a first needle safety cover 410, a second needle safety cover 440, a release arm 480, a cover spring 470 and an indexing ring 500. The first needle safety cover 410, the second needle safety cover 440, the release arm 480 and the cover spring 470 are a part of the needle safety cover assembly 400. The needle safety cover assembly 400 is a telescopic assembly, wherein the distance between the two needle safety cover parts 410, 440 can be changed. The first needle safety cover 410 and the second needle safety cover 440 extend around the syringe holder 300.

[0198] exist Figure 2A and Figure 10AThe syringe 200, shown enlarged in FIG, extends from a proximal end 202 to a distal end 204. The medication is contained within a syringe compartment 206, 206d extending between the proximal and distal ends 204 of the syringe 200. At the proximal end of the syringe 200 is a seal / septum 208, which, when pierced by a needle 222 in a needle assembly 220, forms a syringe outlet 209 for allowing the medication to exit the syringe compartment 206, 206d. A first stopper 212 is located within the syringe compartment 206, 206d, which, when moved in a proximal direction, pushes the medication out of the syringe outlet 209. Typically, the first stopper 212 is pushed proximally using a plunger rod 1018 included in the autoinjector 1000 in which the cartridge 100 having the syringe 200 is installed.

[0199] You can use Figure 2A Alternatively, a single chamber syringe 200 as shown in Figure 10A -Dual chamber syringe 200d shown in -C.

[0200] In the dual-chamber syringe 200d, the syringe compartment 206d includes two sub-compartments 214 and 216. One sub-compartment 216 may include a liquid drug component, and the other sub-compartment 214 may include a solid / powder component. This type of cartridge may be referred to as a liquid-powder two-compartment cartridge. Alternatively, two different liquid components may be present as one liquid in each sub-compartment 214 and 216. This type of syringe 200d may be referred to as a liquid-liquid two-compartment cartridge. The two sub-compartments 214 and 216 may be separated by a second stop 218. The liquid drug component is typically positioned between the two stoppers 212 and 218. When the first stop 212 is moved proximally, the second stop 218 typically moves to a bypass region 217, in which the two drug components are allowed to contact and mix with each other. In the bypass region 217, the liquid component present in the subcompartment 216 between the two stops 212, 218 is allowed to pass near the second stopper 218, thereby entering the subcompartment 214 positioned on the most proximal side for mixing with the solid / powder / liquid component in the subcompartment 214. Further movement of the first stopper 212 pushes the second stopper 218 and the mixed medicament proximally for medicament delivery.

[0201] As an alternative to bypassing the region and mixing the two medicament components, sequential delivery is also conceivable. In this case, the cartridge will typically be a liquid-liquid two-compartment cartridge, wherein the medicament located in the most proximal subcompartment is delivered first, followed by the medicament located in the most distal subcompartment. To enable the use of the medicament located in the most distal subcompartment, one or more internal needles for penetrating the second stopper may be included in the cartridge.

[0202] Figure 2B The needle assembly 220 shown in FIG. 1 includes a needle 222 and a needle hub 224 through which the needle 222 extends. The needle 222 protrudes from both ends of the needle hub 224. During drug delivery, the proximal end 232 of the needle 222 is inserted into the injection site, i.e., into the patient's body. When the needle assembly 220 is fixed to the syringe 220, the distal end 234 of the needle 222 (see FIG. 2 ) is inserted into the syringe 220. Figure 4 A) penetrates the septum 208 in the syringe 200, 200d, thereby establishing the syringe outlet 209. The needle assembly 220 also includes a needle assembly adapter 226 by which the needle assembly 220 can be secured to the syringe holder 300. Prior to use, the needle 222 is protected by a needle cap 228 (e.g., a rigid needle shield).

[0203] Figure 2C The syringe holder 300 shown in FIG extends between a proximal end 302 and a distal end 304. Typically, the syringe holder 300 is positioned relative to the Figure 2I The cartridge housing 600 shown in FIG is longitudinally locked. The needle assembly locking member 306 for connecting the needle assembly 220 to the syringe holder 300 is located at the proximal end 302 of the syringe holder 300. The needle assembly locking member 306 on the syringe holder 300 is connected to the needle assembly adapter 226 on the needle assembly 220 via a threaded connection. The connection between the two components can also be any other type of connection that allows the needle assembly 220 to be fixed to the syringe holder 300. A press-fit connection is an example of such a connection. In addition, a press-fit connection may be the result of a special needle combined with a threaded interface, allowing the special needle to effectively slide on the thread without requiring user-induced rotation. At the end of the sliding movement, the interface between the thread and the interior of the needle holder ensures that the special needle cannot be easily pulled out again. As an alternative, a bayonet fixing principle is also conceivable. With the bayonet fixing principle, the user typically performs a combination of pressing the needle assembly against the syringe holder, which may be combined with a slight rotation of the needle assembly relative to the syringe holder.

[0204] The syringe holder 300 includes an elongated tubular member 308 within which the syringe 200, 200d resides when the syringe 200, 200d is installed in the syringe holder 300. The elongated tubular member 308 has a plurality of openings, including two windows 312 for inspecting the syringe 200, 200d. The elongated tubular member 308 also has two release arm receiving channels 314, each for receiving a release arm 480 (for release arms, see Figure 2GThe release arm receiving channel 314 is closed at the distal end, thereby providing a release arm blocking surface 315 that prevents further distal movement of the release arm 480 once the distal end 484 of the release arm 480 abuts the release arm blocking surface 315 .

[0205] A distal ring member 316 is located at the distal end 304 of the syringe holder 300. The distal ring member 316 includes a plunger opening 318 through which the plunger rod 1018 from the autoinjector 1000 can pass. The plunger opening 318 also allows the syringe 200, 200d to be inserted into the syringe holder 300. The distal ring member 316 also has two release member openings 319 through which the release member 1006 of the autoinjector can pass after the cartridge 100 is assembled in the autoinjector 1000.

[0206] Along the elongated tubular member 308 is a further indexing ring receiving opening 310 for receiving at least a portion of the indexing ring locking projection 506 of the indexing ring 500. The indexing ring locking projection 506 is permitted to rotate within the indexing ring receiving opening 310.

[0207] Figure 2D The first needle safety cover 410 shown in FIG. 1 extends between a proximal end 412 and a distal end 414 and has a tubular shape. An opening 426 in a proximally positioned surface plate 424 is located at the proximal end 412, through which the needle assembly 220 can be attached to the syringe holder 300. When the needle assembly 220 is connected to the syringe holder 300, the needle cap 228 in the needle assembly 220 abuts the proximal surface of the surface plate 424 of the first needle safety cover 410. When the first needle safety cover 410 is in the unlocked initial position Pns1IN, the user can push the needle assembly 220 distally to push the first needle safety cover 410 relative to the syringe holder 300. The first needle safety cover 410 extends at least partially around the second needle safety cover 440. Thus, when the first needle safety cover 410 is pushed distally before both needle safety cover components are in the extended locking position Pns12L, the distal surface of the surface plate 424 of the first needle safety cover 410 contacts the proximal end 442 of the second needle safety cover 440 .

[0208] The surface plate 424 is positioned a short distance distal to the proximal end 412 of the first needle safety cover 410. A narrow inner support surface 428 is thereby formed proximal to the surface plate 424 on the inner surface of the tubular first needle safety cover 410. The inner support surface 428 can be used to support the needle assembly 220 before it is connected to the syringe holder 300. In this way, the needle assembly 220 and the cartridge 100 can be delivered as a combined kit, wherein the needle 222 has not yet penetrated the septum 208.

[0209] The first needle safety cover 410 includes a first locking tab 416. The first locking tab 416 has a proximal ramp 417. The first needle safety cover 410 also includes a second locking tab 420. The two locking tabs 416, 420 are positioned on the inner surface of the first needle safety cover 410. The first locking tab 416 is proximal to the second locking tab 420. The second locking tab 417 also has a proximal ramp 421. The ramps 417, 421 facilitate the proximal movement of the first needle safety cover 410 relative to the second needle safety cover 440 by allowing the flexible arm 446 on the second needle safety cover 440 to move along and past the first ramp 417 and the second ramp 421. Once the flexible arm 446 has moved past either of the two locking tabs 416, 420, the distal surface 418 of the first locking tab 416 and the distal surface 422 of the second locking tab 420 prevent distal movement of the first needle safety cover 410 relative to the second needle safety cover 440. The distal locking tab surfaces 418, 422 are typically generally perpendicular to the longitudinal direction of the cassette 100 or angled in a direction to prevent proximal movement of the flexible arm 446 once the flexible arm is in position such that the flexible arm abuts the distal locking tab surfaces 418, 422.

[0210] The first needle safety cover 410 includes two cover locking tabs 430 that protrude distally and radially outwardly from the tubular cover. The distal end 431 of each cover locking tab 430 abuts against the housing locking protrusion 606 on the inner side of the cartridge housing 600 (see FIG. Figure 2I 606 ). The cover locking tab 430 is flexible, thereby allowing the two distal ends 431 to bend radially inward toward each other. This allows the first needle safety cover 410 to be pushed proximally relative to the cartridge case 600 to an extended position after the drug is injected. When the first needle safety cover 410 moves to the extended position relative to the cartridge case 600, the cover locking tab 430 moves along the ramp 608 on the housing locking protrusion 606. Once the proximal surface 610 of the housing locking protrusion 606 has moved to a position proximal to the housing locking protrusion 606, the proximal surface prevents the cover locking tab 430 from moving distally. This locks the first needle safety cover 410 in the extended position, in which the needle 222 is covered by the first needle safety cover 410 after the drug is delivered.

[0211] There are also two distally extending pins 432 at the distal end 414 of the first needle safety cover 410. The proximal end 472 of the cover spring 470 surrounds each pin 432 (see Figure 2E). The distal end 474 of each cover spring 470 extends around a proximally extending pin 454 on the second needle safety cover 440. Each pin 432, 454 supports the cover spring 470, but other supporting means, such as, for example, an inwardly protruding channel or an outer surface on the cover member 410, 440, may be used instead of a pin for support. In addition, two sets of pins / springs are shown, but the cartridge may also be constructed using only one set of pins / springs or only a single spring.

[0212] The second needle safety cover 440 is Figure 2F 4. The second needle safety cover 440 extends between a proximal end 442 and a distal end 444. The second needle safety cover 440 has a tubular component 452. The first needle safety cover 410 extends at least partially around the tubular component 452 of the second needle safety cover 440. A flexible arm 446 extends distally from the proximal end 442 of the needle safety cover 440. The distal end 447 of the flexible arm 446 has a ramp surface 448 that contacts the ramp surfaces 417, 421 on the locking tabs 416, 420 of the first needle safety cover 410 when the two needle safety cover components 410, 440 move away from each other. Once either locking tab 416, 420 has moved proximally past the flexible arm 446, a proximal stop surface 449 on the flexible arm 446 prevents the locking tabs 416, 420 from moving distally and rearwardly. When the two second locking tabs 420 have moved to a position proximal to the distal ends 447 of the flexible arms 446 , the stop surfaces 450 prevent further telescoping separation of the two needle safety cover components 410 , 440 when the first locking tabs 416 abut the stop surfaces 450 .

[0213] When the release arm 480 is in the initial position PraIN relative to the syringe holder 300, the release arm 480 prevents the two needle safety cover components 410, 440 from telescopically moving away from each other. In the initial position PraIN, the release arm 480 prevents the flexible arm 446 from flexing, thereby preventing the locking tabs 416, 420 of the first needle safety cover 410 from moving proximally past the ramp surface 448 of the flexible arm 446.

[0214] The tubular member 452 has an inspection opening 458 for inspecting the syringe 200, 200d. The flexible arm 446 is positioned within the inspection opening 458. A distally extending pin 456 extends distally from the tubular member 452. A proximally extending pin 454, around which the cover spring 470 is positioned, extends from the proximal end surface of the distally extending pin 456. The second needle safety cover 440 generally has the distally extending pin 456 and the inspection opening 458 symmetrically disposed on both sides of the second needle safety cover 440.

[0215] The distal end 457 of the distally extending pin 456 may interact with the autoinjector 1000 by activating a sensor that notifies the autoinjector 1000 that the cartridge 100 has been secured in the autoinjector 1000 .

[0216] The distally extending pin 456 includes a first locking recess 460 and a safety cover locking protrusion 462. The safety cover locking protrusion 462 is located distal to the first locking recess 460. The first locking recess 460 and the safety cover locking protrusion 462 interact and couple with the indexing ring 500. The indexing ring 500 (see Figure 2H ) includes an indexing ring locking projection 506 that is secured within the first locking recess 460 prior to securing the cartridge 100 in the autoinjector. When the indexing ring locking projection 506 is fully positioned within the first locking recess 460, the second needle safety cover 440 is longitudinally locked to the indexing ring 500. Because the indexing ring 500 is typically longitudinally locked to the syringe holder 300, when the indexing ring locking projection 506 is fully positioned within the first locking recess 460, the second needle safety cover 440 is longitudinally locked to the syringe holder 300.

[0217] The indexing ring 500 is rotatable relative to the second needle safety cover 440. Rotation of the indexing ring 500 is controlled by movement of one or more release members 1006 in the autoinjector 1000 into and out of the cartridge 100. When the indexing ring 500 is rotated from the initial first rotational position R1 to the second rotational position R2, the indexing ring locking projection 506 moves to a position where it no longer prevents distal movement of the second needle safety cover 440. In the second rotational position R2, the second needle safety cover 440 is still prevented from proximal movement by the safety cover locking projection 462. The safety cover locking projection 462 extends radially further than the surface 464 of the distally extending pin 456 located proximal to the first locking recess 460. In some examples, there is no difference between the first locking recess 460 and the surface 464. In the second rotational position R2, the second needle safety cover 440 can be pushed distally, thereby securing the needle assembly 220 to the syringe holder 300.

[0218] Further rotational movement of the index ring 500 from the second rotational position R2 to the third rotational position R3 completely disengages the index ring locking projection 506 from contact with the safety cover locking projection 462 and the first locking recess 460. In the third position R3, the second needle safety cover 440 is permitted to move proximally relative to the syringe holder 300. Typically, when drug delivery is initiated by proximal movement of the plunger rod 1018 in the autoinjector, the autoinjector 1000 rotates the index ring 500 to the third rotational position R3.

[0219] When the user removes the cartridge 100 and autoinjector 1000 system from the injection site, the needle safety cover spring system 1026 in the autoinjector 1000 pushes the second needle safety cover 440 proximally to the extended position. After the medicament is delivered, the autoinjector 1000 retracts the one or more release members 1006. The retraction of the one or more release members 1006 rotates the indexing ring 500 from the third rotational position R3 to the first rotational position R1. When the indexing ring 500 has rotated to the first rotational position R1, the cartridge is in the final locked position PnsFL, from which both needle safety cover components 410, 440 are prevented from moving distally. This is because the safety cover locking projection 462 is now located proximal to the indexing ring locking projection 506, which prevents distal movement of the second needle safety cover 440.

[0220] The second needle safety cover 440 also includes a proximal end surface 465 against which the first needle safety cover 410 abuts when the needle assembly 220 is secured to the syringe holder 300 .

[0221] Figure 2G The release arms 480 shown in FIG each extend between a proximal end 482 and a distal end 484. At the distal end 484 of each release arm 480 are two flexible fingers 490 that can flex toward each other. The release arms 480 are positioned in a release arm receiving channel 341 in the syringe holder 300. When the release arms 480 move distally from an initial position PraIN to a release position PraR within the release arm receiving channel 341, the flexible fingers 490 on each release arm 480 are forced toward each other by the narrowing of the release arm receiving channel 341. The release arm receiving channel 314 closes at the distal end, thereby providing a release arm blocking surface 315 that prevents further distal movement of the flexible fingers 490 once they abut the release arm blocking surface 315. At the proximal end 482 of the release arm 480, the release arm 480 is bent toward the center of the cartridge 100 when the release arm 480 is positioned in the release arm receiving channel 341. Instead of two separate release arms 480, a release ring is also contemplated in which a tubular ring member connects the release arms. Using only one release arm is also an option.

[0222] When the release arm 480 is positioned in the release arm receiving channel 341, the protruding surface release member 486 on the release arm 480 is located on the outwardly directed surface side. In the initial position PraIN, the protruding surface release member 486 is positioned distally compared to when it is in the release position PraR. In the initial position PraIN, the protruding surface release member 486 prevents the first needle safety cover 410 from moving proximally because the flexible arm 446 on the second needle safety cover 440 cannot flex to allow the first locking tab 416 on the first needle safety cover 410 to pass. When the release arm 480 moves to the release position PraR, the flexible arm 446 on the second needle safety cover 440 can flex, allowing the first needle safety cover 410 to be pushed to the extended position relative to the second needle safety cover 440 by the pressure from the cover spring 470 between the two needle safety covers 410, 440.

[0223] Figure 2H The indexing ring 500 shown in FIG extends from a proximal end 502 to a distal end 504. The indexing ring 500 is positioned around the syringe holder 300 and is typically longitudinally locked to the syringe holder 300. The indexing ring 500 is rotationally movable relative to the syringe holder 300 between a plurality of rotational positions, the plurality of rotational positions including at least a first rotational position R1 in which the second needle safety cover 440 is prevented from moving distally and a second rotational position R2 in which the second needle safety cover 440 is able to move distally. Figure 3 AL and Figure 4 Shown in AL.

[0224] The indexing ring 500 has two indexing ring locking tabs 506, each located at the distal end of an indexing ring arm 508. The release function of the indexing ring locking tabs 506 is described above.

[0225] The indexing ring 500 also has a tubular indexing ring component 510 that extends around the syringe holder 300. The indexing ring 500 also includes a surface area 512 that partially constitutes a portion of the tubular indexing ring component 510. The surface area 512 includes a track 514 that extends from a first corner 516 of the surface area 512 to a second corner 518 of the surface area 512. The track 514 extends in an angled direction from the first corner 516 toward the second corner 518. The angled direction is typically between 20 degrees and 70 degrees, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees, relative to the longitudinal direction of the cartridge.

[0226] exist Figure 2HIn the track 514 shown in FIG, the track 514 includes a first track segment 520, a second track segment 522, and a third track segment 524. The first track segment 520 extends from the first corner 516 toward a first midpoint 526 in a first angular direction, the second track segment 522 extends from the first midpoint 526 to a second midpoint 528 in a second angular direction along the longitudinal direction of the box, and the third track segment 524 extends from the second midpoint 528 toward the second corner 518 in a third angular direction. The first angular direction and / or the third angular direction are normally inclined directions having an angle of between 20 and 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees, relative to the longitudinal direction of the box. The second track segment 522 is typically a platform track segment having a second angled orientation relative to the longitudinal direction of the cassette between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees.

[0227] When the cartridge 100 is secured in the autoinjector 1000, the rotational position of the indexing ring locking projection 506, and thereby the rotational position of the indexing ring 500 relative to the second needle safety cover 440, is controlled by one or more release members 1006 in the autoinjector 1000. More specifically, the indexing ring 500 is configured to rotate from a first rotational position R1 to a second rotational position R2 and then to a third rotational position R3 when the cartridge 100 is inserted into the autoinjector 1000 and the track guide projections 1008 on the one or more release members 1006 travel proximally within the tracks 514. When the track guide projections 1008 travel distally again, the indexing ring 500 rotates from the third rotational position R3 back to the second rotational position R2 and then back to the first rotational position R1. Thus, by retrieving the release member 1006 with the track guide projections 1008 into the autoinjector, the indexing ring rotates back to its initial rotational position R1.

[0228] Figure 2I600 extends from a proximal end 602 to a distal end 604 and has an opening 612 at the distal end 604 through which the indexing ring 500, the needle safety cover components 410, 440 and the syringe holder 300 are mounted. When the cassette 100 is assembled, the cassette housing 600 at least partially (if not completely) surrounds the syringe holder 300, the syringe 200, 200d when positioned in the syringe holder 300, the needle safety cover components 410, 440 and the indexing ring 500. The syringe holder 300 will typically be longitudinally and rotationally locked to the cassette housing 600. The cassette housing 600 has an inspection window 614 on at least one surface side that allows a user to inspect the syringe compartment 206, 206d containing the medicament when the syringe 200, 200d is mounted inside the cassette 100. The cartridge 100 can be symmetrically configured so that it can be installed in different orientations in the autoinjector 1000. A cartridge securing tab 616 is positioned at the distal end 604 of the cartridge housing 600. The cartridge securing tab 616 is flexible and is used to secure the cartridge 100 in the autoinjector 1000.

[0229] As described above, the housing locking protrusions 606 on the inside of the cartridge housing 600 interact with the cover locking tabs 430 of the first needle safety cover 410 .

[0230] Figure 3 AL shows the cartridge 100 in a partially cutaway perspective view during installation of the needle assembly 220 and medicament delivery, and Figure 4 AL shows a cutaway portion in the middle of the cartridge 100. Figure 3 A and Figure 4 As shown in A, the cartridge 100 extends from a proximal end 102 to a distal end 104. Figure 3 A and Figure 4 In Figure 6A, the cartridge 100 is in a delivery state prior to attaching the needle assembly 220. The proximal end 412 of the first needle safety cover 410 protrudes slightly outside the cartridge housing 600. The first needle safety cover 410 is urged proximally by the cover spring 470. However, the release arm 480 prevents the first needle safety cover 410 from further proximal movement to the fully extended position Pns12L, in which the two needle safety cover components 410, 440 are locked relative to each other.

[0231] exist Figure 3 B and Figure 4 In B, needle assembly 220 rests against inner bearing surface 428 and proximally positioned surface plate 424. Figure 3 C and Figure 4In Figure C, the needle assembly 220 and the first needle safety cover 410 have been pushed distally, causing the proximally positioned surface plate 424 of the first needle safety cover 410 to contact the proximal end 442 of the second needle safety cover 440. Further distal movement of the two needle safety cover components 410, 440 is prevented by longitudinally locking the indexing ring 500 of the second needle safety cover 440. The needle assembly 220 cannot be connected to the syringe holder 300 in this position, and the needle safety cover components 410, 440 serve as a needle assembly blocking system.

[0232] exist Figure 3 D and Figure 4 In D, the indexing ring 500 has been released from the automatic injector 1000 by the release member 1006 (not visible). Figure 3 The first rotation position R1 shown in AC is rotated to the second rotation position R2, and the release member moves into the box 100, thereby rotating the index ring 500. Figure 3 E and Figure 4 As shown in FIG. E, when the needle assembly 220 is fixed to the syringe holder 300, the distal movement of the two needle safety cover components 410, 440 is now possible. When the needle assembly 220 is fixed to the syringe holder 300, the release arm 480 is moved from the initial position PraIN (as shown in FIG. Figure 3 A and Figure 4 When the needle cap 228 is removed from the needle assembly 220, the cover spring 470 pushes the first needle safety cover 410 in the proximal direction, thereby moving the second needle safety cover 440. Figure 3 F and Figure 4 F. Depending on the strength of the cover springs 470, the movement pattern of the two needle safety covers 410, 440 can vary. If the two cover springs 470 have a higher spring force than the spring force of the needle safety cover spring system 1026 in the autoinjector 1000 acting on the second needle safety cover 440, the two cover springs 470 will expand first and the second needle safety cover 440 will initially remain behind. Alternatively, if the two cover springs 470 have a lower spring force than the spring force of the needle safety cover spring system 1026 in the autoinjector 1000 acting on the second needle safety cover 440, the two needle safety covers 410, 440 will initially move simultaneously until the final stop of the movement of the needle safety cover spring system 1026, after which the cover springs 470 will expand for the corresponding end position of the first needle safety cover, as shown in FIG. Figure 3 As shown in F.

[0233] When the safety cover locking projection 462 of the second needle safety cover 440 contacts the indexing ring locking projection 506, the second needle safety cover 440 is prevented from further moving in the proximal direction, as shown in FIG. Figure 3 G and Figure 4G. However, since the release arm 480 is in the release position PraR, the first needle safety cover 410 is allowed to continue to move proximally, which allows the first needle safety cover 410 to enter the position as shown in FIG. Figure 3 H and Figure 4 H. In the fully extended position Pns12L, the first needle safety cover 410 and the second needle safety cover 440 are locked relative to each other, thereby forming a combined needle safety cover 408, which is allowed to move distally as a single object. Figure 3 I and Figure 4 I, and medication delivery begins when the user presses the cartridge against the syringe site.

[0234] The autoinjector can detect that the combined needle safety cover 408 has been activated, for example, by the distal end 457 of the distally extending pin 456 contacting the needle safety cover pin 1024 to activate the switch and push it distally, thereby activating the delivery of the drug. Alternatively, the user can manually press the button on the autoinjector 1000 and activate the drug delivery. During the activation of the drug delivery, the indexing ring 500 is rotated by the release member 1006, which is further moved into the cartridge 100, thereby causing the indexing ring 500 to rotate further. This is Figure 3 J and Figure 4 Shown in J.

[0235] The needle safety cover spring system 1026 in the automatic injector 1000 pushes the syringe needle safety cover pin 1024 proximally. The syringe needle safety cover pin 1024 then contacts the distal end 457 of one of the distally extending pins 456 on the second needle safety cover 440. During the delivery of the medicament, the syringe needle safety cover pin 1024 moves proximally, thereby biasing the needle safety cover spring system 1026. When the user removes the cartridge from the injection site after finishing the medicament delivery, the combined needle safety cover 408 is pushed proximally by the needle safety cover spring system 1026. Since the indexing ring 500 is in the third rotational position R3, the combined needle safety cover 408 is now allowed to move to the extended position covering the needle 222. This is Figure 3 K and Figure 4 As shown in K. Figure 4 As best seen in Figure K, the first needle safety cover 410 is locked in place within the cartridge housing 600. When the release member 1006 is again retracted distally into the autoinjector 1000, the indexing ring 500 rotates back to the first rotational position R1, wherein the indexing ring 500 prevents distal movement of the combined needle safety cover 408, as shown in Figure 1. Figure 3 L and Figure 4 L. The cartridge 100 is now locked in a position where the needle 222 is protected and can be removed from the autoinjector 1000.

[0236] Figure 5 A shows an alternative example of the second needle safety cover 440', in which there is no difference between the first locking recess 460 and the surface 464. This means that in both the first rotational position R1 and the second rotational position R2 of the index ring 500, the needle assembly 220 can be fixed to the syringe holder 300 because the second needle safety cover 440' can be pushed distally. Figure 5 B and Figure 5 C, further rotational movement of the index ring 500 from the second rotational position R2 to the third rotational position R3 completely disengages the index ring locking projection 506 from contact with the safety cover locking projection 462 and the first locking recess 460. Typically, the autoinjector 1000 rotates the index ring 500 to the third rotational position R3 when medicament delivery is initiated by proximal movement of the plunger rod 1018 in the autoinjector. Figure 5 The drug delivery location is shown in D, and Figure 5 The final locked position after drug delivery is shown in E.

[0237] Figure 6 AH show the second cartridge 100b during installation of the needle assembly 220b and during medicament delivery. Figure 7 An exploded view of the different parts of the second example of the cartridge 100b and the second example of the needle assembly 220b is shown. Similar parts are labeled with "b", but the same reference numerals are used for the same parts. Figure 6 As shown in FIG. 1A , the cartridge 100b extends from a proximal end 102b to a distal end 104b .

[0238] and Figure 1 、 Figure 2A -I. Figure 3 AL and Figure 4 Compared with the needle assembly 220 shown in AL, the needle assembly 220b that is configured to be connected to the second box 100b comprises needle assembly shield 235b, and this needle assembly shield can deflect in the distal direction to expose pin 222b.Needle assembly shield spring (not shown) pushes needle assembly shield 235b in the proximal direction after use, for protecting pin 222b.Other parts of needle assembly 220b also comprise needle seat 224b, needle assembly adapter 226b and needle cap 228b.After needle assembly 200b is fixed to syringe holder 300 by needle assembly adapter 226b being fixed to the needle assembly locking part 306 of syringe holder 300, needle cap 228b can be removed from needle assembly 220b.

[0239] and Figure 1 、 Figure 2A -I. Figure 3 AL and Figure 4Compared to the cartridge 100 shown and described in AL, Figure 7 The box 100b shown in the exploded view does not have a telescopically extendable component, but rather includes a single-piece needle mounting and blocking system 400b. The needle mounting and blocking system 400b includes the same components as shown in FIG. Figure 1 、 Figure 2A -I. Figure 3 AL and Figure 4 AL shows and describes similar components to the second needle safety cover 440. The needle mount barrier system 400b extends from a proximal end 402b to a distal end 404b.

[0240] The needle mounting and blocking system 400b has a tubular member 452b. Extending distally from the tubular member 452b is a distally extending pin 456b. The needle mounting and blocking system 400b is generally symmetrical, with a distally extending pin 456b on each side of the needle mounting and blocking system 400b.

[0241] The distal end 457b of the distally extending pin 456b may interact with the autoinjector 1000 by activating a sensor that notifies the autoinjector 1000 that the cartridge 100b has been secured in the autoinjector 1000. Alternatively, the cartridge insertion detection sensor system may be positioned at a different location in the autoinjector 1000.

[0242] The distally extending pin 456b includes a first locking recess 460b and a blocking system locking projection 462b. The blocking system locking projection 462b is positioned distal to the first locking recess 460b. The first locking recess 460b and the blocking system locking projection 462b interact and couple with the indexing ring 500. The indexing ring 500 (see Figure 2H ) includes an indexing ring locking projection 506 that is secured within the first locking recess 460b prior to securing the cartridge 100b in the autoinjector 1000. When the indexing ring locking projection 506 is fully positioned within the first locking recess 460b, the needle installation blocking system 400b is longitudinally locked to the indexing ring 500. Since the indexing ring 500 is typically longitudinally locked to the syringe holder 300, the needle installation blocking system 400b is longitudinally locked to the syringe holder 300 when the indexing ring locking projection 506 is fully positioned within the first locking recess 460b.

[0243] The indexing ring 500 is rotatable relative to the needle mounting block system 400b. The rotation of the indexing ring 500 is controlled by the movement of one or more release members 1006 in the automatic injector 1000 into / out of the cartridge 100b. When the indexing ring 500 is rotated from the initial first rotational position R1 to the second rotational position R2, the indexing ring locking projection 506 moves to a position where it no longer prevents the needle mounting block system 400b from moving distally. This can be seen by comparing Figure 6 AC. In the second rotational position R2, the needle mounting blocking system 400b is prevented from moving proximally by the blocking system locking protrusion 462b. The blocking system locking protrusion 462b extends radially farther than the surface 464b of the distally extending pin 456b present on the proximal side of the first locking recess 460b. In some examples, there is no difference between the first locking recess 460b and the surface 464b. In the second rotational position R2, since the needle mounting blocking system 400b can be pushed distally, the needle assembly 220b can be fixed to the syringe holder 300. Figure 6 In FIG. 4C , needle installation blocking system 400b has been pushed distally and needle assembly 220b is installed.

[0244] Figure 6 AH shows the second cartridge during installation of the needle assembly 220b and medicament delivery and its interaction with the autoinjector 1000 during this process. Figure 6 At AH, the rotation of the indexing ring 500 by the release member 1006 in the syringe 1000 can be seen. Figure 6 In A, the cartridge 100b has just been installed in the autoinjector 1000. Figure 6 In B, the autoinjector 1000 has detected the presence of the cartridge 100b and has locked the cartridge 100b to the autoinjector 1000 and has moved the release member 1006 proximally to rotate the indexing ring 500 to the second rotational position R2. Figure 6 When the needle assembly 220b is pushed distally as shown in FIG. C to secure it to the cartridge 100b, the switch 1032 is activated. This causes the release member 1006 to move further proximally to rotate the indexing ring 500 to the third rotational position R3, as shown in FIG. Figure 6 As shown in D. When the needle cap 228b is removed, the needle mounting blocking system 400b moves proximally, as shown in FIG. Figure 6 E. To deliver the medication, the autoinjector 1000 and cartridge 100b system is pressed against the patient's skin and the needle assembly shield 235b of the needle assembly 220b is pushed distally. Figure 6 F. After the medicament is delivered, the release member 1006 in the syringe 1000 is retracted distally, thereby rotating the indexing ring 500 to the first rotational position R1, as shown in FIG. Figure 6 G. When the cartridge 100b is removed from the patient's skin, the needle assembly shield spring within the needle assembly 220b forces the needle assembly shield 235b of the needle assembly 220b to proximally cover the needle 222b, as shown in FIG. Figure 6 As shown in H.

[0245] Figure 8AF shows the third cassette 100c extending from the proximal end 102c to the distal end 104c before being connected to the needle assembly 220b, during installation of the needle assembly 220b, and during medicament delivery. Like components are labeled "c", but the same reference numerals are used for like components compared to the first and second examples of the cassettes 100, 100b described previously. Figure 9 AH with Figure 6 Similar views AH show the third cartridge 100c during installation of a second example of a needle assembly 220b and during medicament delivery.

[0246] exist Figure 8 In A, the cartridge 100c is in the pre-use position, with the needle mounting blocking system 400b in the unlocked initial position Pns1IN. Figure 8 In BD, the cartridge 100c is in a position where the needle assembly 220b has been secured to the cartridge 100c, and the needle mounting blocking system 400b is in the needle assembly connection position PnsC. Figure 8 In EF, the cartridge 100c is in a post-use position with the needle mounting blocking system 400b in the final locked position PnsFL. Figure 8 D and Figure 8 In F, the cartridge housing 600 is removed from the cartridge 100c. Figure 8 D and Figure 8 F and Figure 8 C and Figure 8 Same as E.

[0247] exist Figure 9 In A, the cartridge 100c has been inserted into the autoinjector 1000 but has not yet been secured therein. Therefore, the indexing ring 500 has not yet been rotated from the initial first rotational position R1 to the second rotational position R2. Therefore, installation of the needle assembly 220b is not yet possible. Figure 9 In FIG. 1B , the cartridge 100c has been locked in the autoinjector 1000 and the index ring 500 has been rotated to a first rotational position R1 in which the index ring locking projection 506 has moved to a position where it no longer prevents the needle installation blocking system 400b from moving distally. In the second rotational position R2 , the needle installation blocking system 400b can be pushed distally so that the needle assembly 220b can be secured to the syringe holder 300. Figure 9 In C, needle installation blocking system 400b has been pushed distally and needle assembly 220b is installed. Figure 9 In D, the needle cap 228b is removed. To deliver the medication, the autoinjector 1000 and cartridge 100c system is pressed against the patient's skin and the needle assembly shield 235b of the needle assembly 220b is pushed distally. Figure 9E. The plunger rod 1018 moves proximally to push the medication out of the syringe 200, 200d. Figure 9 F. After the medicament is delivered, the release member 1006 in the syringe 1000 is retracted distally, thereby rotating the indexing ring 500 to the first rotational position R1, as shown in FIG. Figure 9 G. When the cartridge 100c is removed from the patient's skin, the needle assembly shield spring within the needle assembly 220b forces the needle assembly shield 235b of the needle assembly 220b to proximally cover the needle 222b, as shown in FIG. Figure 9 H. When the indexing ring 500 has been rotated to the first rotational position R1, the cartridge 100c is in the final locking position PnsFL, from which the needle installation blocking system 400b is prevented from moving distally or proximally. This is achieved by the indexing ring locking protrusion 506 now fitting into the second locking recess 461b of the distally extending pin 456b. When the cartridge 100c is used for drug delivery, the needle installation blocking system 400b is thus in the final locking position PnsFL, which is distal to the locking position PnsL. Therefore, the final locking position PnsFL is identical to the needle assembly connection position PnsC and the drug delivery position PnsD.

[0248] The indexing ring can be Figure 9 The indexing ring 500 shown in FIG. 1A and FIG. 1H differs from the indexing ring 500 shown in FIG. 1A and FIG. 1H because it does not rotate to the third rotational position R3. The indexing ring 500 used in cassette 100c may lack the equivalent of the third track segment 524 of the first example of the indexing ring 500. During medicament delivery, the indexing ring 500 may be in the second rotational position R2. If the distally extending pin 456b is not extended far enough in the distal direction for the needle safety cover spring system 1026 to apply a proximal thrust to the distally extending pin 456b, the needle safety cover spring system 1026 in the autoinjector 1000 does not need to proximally push the needle installation blocking system 400b to the extended position. After medicament delivery, when the autoinjector 1000 retracts the one or more release members 1006, the indexing ring 500 rotates from the second rotational position R2 to the first rotational position R1.

[0249] Figure 10A -C shows a dual chamber syringe 200d having a first sub-compartment 214 and a second sub-compartment 216 as previously described.

[0250] Figure 11The fourth cartridge 100d is shown in an exploded view. The fourth cartridge 100d includes a syringe holder 300d, a first needle safety cover 410d, a second needle safety cover 440d, a cover spring 470, an indexing ring 500d, and a cartridge housing 600d. With the exception of the cover spring 470, the other cartridge components 410d, 440d, 500d, 600d are slightly alternative examples of the previously discussed components in the first example of cartridge 100. Like components are labeled with "d," but the same reference numerals are used for like components compared to the first, second, and third examples of cartridges 100, 100b, 100c described previously. Compared to the first example of cartridge 100, the fourth example of cartridge 100d lacks a separate release arm. Instead, the release arm 580 in the fourth example of cartridge 100d is positioned as part of the indexing ring 500d, as Figure 12E As shown in .

[0251] Figure 12A In addition to the components already described for the first version of the cartridge housing 600, Figure 12A d. The cartridge case 600d shown in FIG. 6 includes a first needle safety cover stop surface 618 that prevents the first needle safety cover 410d from being pushed out of the cartridge case 600d toward the proximal side in the final locked position by making the distal end cover locking tab 431 abut against the first needle safety cover 410d. The cartridge case 600d also includes at least one first needle safety cover passage 620, in which the cartridge case guide tab 429 advances. The passage 620 and the guide tab 429 couple to rotationally locking the cartridge case 600d and the first needle safety cover 410d.

[0252] Figure 12B -C shows the first needle safety cover 410d from two different directions. In addition to the above-mentioned cartridge housing stop surface 438 and cartridge housing guide tab 429 and the components already described for the first version of the first needle safety cover 410, Figure 12B-C shows the first needle safety cover 410d further comprising a cover locking tab 430, wherein the distal cover locking tab 431d prevents the first needle safety cover 410d from being proximally pushed out of the cartridge housing 600d in the final locked position. The first needle safety cover 410d further comprises a distal first needle safety cover locking surface 436 and a proximal first needle safety cover locking surface 437. In the Pns12L position, the distal first needle safety cover locking surface 436 abuts the proximal second needle safety cover locking tab 466 on the second needle safety cover 440d, thereby preventing distal movement of the first needle safety cover 410d relative to the second needle safety cover 440d. Similarly, in the Pns12L position, the first needle safety cover interface 435 abuts the distal second needle safety cover locking tab 467 on the second needle safety cover 440d, thereby preventing proximal movement of the first needle safety cover 410d relative to the second needle safety cover 440d. In this way, the two needle safety cover components 410d, 440d are locked relative to each other in the Pns12L position.

[0253] The first needle safety cover 410d also includes a first needle safety cover arm 434 having a first indexing ring engaging finger 433 and a first needle safety cover interface 435. When the indexing ring 500d is in the first rotational position R1, the first indexing ring engaging finger 433 on the first safety cover 410d abuts at least one of the one or more release arms 580 on the indexing ring 500d, thereby preventing proximal movement of the first needle safety cover 410d relative to the indexing ring 500d. When the first needle safety cover 410d and the second needle safety cover 440d are in the extended locked position, the first needle safety cover interface 435 abuts the distal second needle safety cover locking tab 467, thereby preventing further proximal movement of the first needle safety cover 410d relative to the second needle safety cover 440d.

[0254] Figure 12D100d. The second needle safety cover 440d is shown. In addition to the above-mentioned proximal second needle safety cover locking tab 466 and distal second needle safety cover locking tab 467 and the components described for the first version of the second needle safety cover 440, the second needle safety cover 440d also includes a second indexing ring engaging finger 469 and a second needle safety cover interface 468. When assembled with the indexing ring 500d, the second needle safety cover interface 468 holds the two needle safety cover components 410d and 440d together. Before the box 100d is positioned in the automatic injector 1000, the second needle safety cover interface 468 abuts the release arm 580. The cover spring 470 positioned around the proximally extending pin 454 on the second needle safety cover 410d and the distally extending pin 432 on the first needle safety cover 440d will attempt to push the needle safety cover components 440d and 410d away from each other. However, before the needle safety cover components 410d, 440d are released relative to each other by the release arm 580 on the index ring 500d, the release arm 580 locks the needle safety cover components 410d, 440d together in the unlocked initial position Pns1IN.

[0255] Figure 12F -G shows the syringe holder 300d from two different directions. In addition to the indexing ring release arm 330 having the protruding surface 332 and the components already described for the first version of the syringe holder 300, the syringe holder 300d also includes a cartridge detection tab 320 (also present in FIG. Figure 2C ), which abuts the cartridge detection pin 1080 inside the autoinjector 1000 for cartridge detection. Figure 12F The syringe holder 300d shown in FIG. 1-G further includes a syringe support surface 322 and a syringe fixing hook 324 for supporting and fixing the syringes 200, 200d in the syringe holder 300d. These components may be omitted.

[0256] Figure 12E In addition to the components already described for the first version of the indexing ring 500, Figure 12EThe indexing ring 500d shown in FIG includes a second track 544 positioned on the indexing ring arm 508. The second track 544 includes a first sub-track segment 550, a second sub-track segment 552, a third sub-track segment 554, and a fourth sub-track segment 555. The first sub-track segment 550 extends in a first angular direction from the first sub-corner 546 toward the first sub-midpoint 556. The second sub-track segment 552 extends in a second angular direction along the longitudinal direction of the cassette 100d from the first sub-midpoint 556 to the second sub-midpoint 558. The third sub-track segment 554 extends in a third angular direction from the second sub-midpoint 558 toward the second sub-corner 548. The fourth sub-track segment 555 extends distally from the second sub-corner 548. The first angled direction and / or the third angled direction are normally tilted directions having an angle of between 20 and 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees, relative to the longitudinal direction of the box. The second secondary track segment 522 is typically a platform track segment having a second angled direction of between -20 and 20 degrees, such as between -10 and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box. The fourth secondary track segment 555 is also typically a platform track segment having a fourth angled direction of between -20 and 20 degrees, such as between -10 and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box.

[0257] Before the cartridge 100d is inserted into the autoinjector 1000, the indexing ring 500d is locked relative to the needle safety covers 410d, 440d. This is due to the blocking surface 540 on the indexing ring 500d abutting the protruding surface 332 on the indexing ring release tab 330 on the syringe holder 300d. When the cartridge 100d is positioned in the autoinjector 1000, one or more release members 1006 in the autoinjector 1000 advance proximally into the cartridge 100d, contacting the indexing ring release tab 330. This causes the indexing ring release tab 330 to flex radially inward. By doing so, the blocking surface 540 on the indexing ring 500d no longer abuts the protruding surface 332. This allows the indexing ring 500d to rotate from the first rotational position R1 to the second rotational position R2.

[0258] Rotation of the index ring 500d from the first rotational position R1 toward the second rotational position R2 is controlled by the user attaching the needle assembly 220 to the needle assembly locking member 306 on the syringe holder 300d by pushing the needle safety cover components 410d, 440d distally. The second index ring engagement finger 469 on the second needle safety cover 440d abuts the first secondary track 550 of the second track 544, thereby forcing the index ring 500d to rotate toward the second rotational position R2 when the user pushes the needle safety cover components 410d, 440d distally.

[0259] Rotation of the indexing ring 500d causes the release arm 580 to release from the first indexing ring engagement finger 433. This allows the cover spring 470 to move the first needle safety cover 410d proximally relative to the second needle safety cover 440d after the needle assembly 220 is installed. The cover spring 470 causes the first needle safety cover 410d to move proximally relative to the second needle safety cover 440, pushing the needle safety covers 410d, 440d into a locked cover position, in which further relative longitudinal movement between the first and second needle safety covers 410d, 440d is prevented. As described above, proximal locking is achieved by a first locking pair comprising the proximal first needle safety cover interface 435 and the distal second needle safety cover locking tab 467. Distal locking is achieved by a second locking pair comprising the distal first needle safety cover locking surface 436 and the proximal second needle safety cover locking tab 466, as described above.

[0260] In the second rotational position R2 of the indexing ring 500d, the second indexing ring engagement finger 469 on the second needle safety cover 440d abuts the release arm 580, thereby preventing further proximal movement of the needle safety covers 410d, 440d. Figure 14G Visible in.

[0261] After the one or more release members 1006 of the autoinjector are proximally moved from a first release member position within the cartridge 100d to a second release member position within the cartridge 100d, the indexing ring 500d can be rotated from the second rotational position R2 to the third rotational position R3. After the proximal movement of the one or more release members 1006 of the autoinjector 1000, the indexing ring 500d can be rotated from the second rotational position R2 to the third rotational position R3 by distal movement of the first needle safety cover 410d. This is accomplished when the user presses the first needle safety cover 410d against the injection site for needle insertion. For more details, see Figure 13 HI.

[0262] When the indexing ring 500d is rotated from the second rotational position R2 to the third rotational position R3 by the distal movement of the first needle safety cover 410d for needle insertion and drug delivery, the second indexing ring engaging finger 469 no longer abuts the release arm 580 in the proximal direction. This allows the needle safety cover 410d, 440d to move proximally relative to the indexing ring 500d to the final locking position PnsFL after drug delivery is completed. Therefore, the second indexing ring engaging finger 469 is allowed to move proximally to the release arm 580 to the final locking position PnsFL, as shown in FIG. Figure 13 As shown in JK.

[0263] Figure 13 AK is shown in cross-section with Figure 3 A similar sequence is shown in AL with a fourth cartridge during installation of the needle assembly and subsequent medicament delivery. Figure 13 In A, the cartridge 100d has not yet been inserted into the autoinjector and the needle assembly 220 has not yet been attached to the cartridge 100d. Figure 13 In B, the cartridge 100d has been positioned within the auto-injector and the release member 1006 has been moved proximally to lock the cartridge 100d within the auto-injector. The indexing ring 500d has not yet been rotated, but can now be rotated from the first rotational position R1 to the second rotational position R2 by the user installing the needle assembly 220. Figure 13 In C, the first needle safety cover 410d has moved distally relative to the second needle safety cover 440d. This causes the indexing ring 500d to rotate slightly (see Figure 14C ), and with Figure 13 The cover spring 470 is further compressed compared to that shown in B.

[0264] exist Figure 13 In FIG. 3 , the needle assembly 220 has been secured to the syringe holder 300 d and the indexing ring 500 d has been rotated to the second rotational position R2 by the second indexing ring engaging finger 469 travelling along the first and second sub-tracks 550, 552 of the second track 544 (see FIG. 3 ). Figure 14D -F). In this position, the first needle safety cover 410d is unlocked relative to the second needle safety cover 440d. Figure 13 In E, the needle cap 228 has been removed, whereby the first needle safety cover 410d is urged by the spring force of the cover spring 470 to a proximally extended position covering the needle 208. The release arm 580 prevents movement to the outermost proximal position of the needle safety covers 410d, 440d by abutment with the second indexing ring engagement finger 469. However, in this position, the needle safety covers 410d, 440d are locked relative to each other. Figure 13In FIG. 5 , the needle safety covers 410d and 440d are pushed distally to remove the rigid needle shield 236. After the rigid needle shield 236 is removed, the needle safety covers 410d and 440d are moved to the position where they are located due to the needle safety cover spring system 1026 of the autoinjector. Figure 13 The location of E.

[0265] Figure 13 H shows the movement of the plunger rod 1018 and release member 1006 for mixing the medicaments in the two sub-compartments 214, 216 when the dual chamber syringe 200d is used. This step can be omitted if the single chamber syringe 200 is used.

[0266] exist Figure 13 In FIG. 1 , the needle 208 is inserted into the injection site by pushing the first needle safety cover 410 d against the injection site, and the medicament is delivered. Pushing the first needle safety cover 410 d against the injection site also causes the indexing ring 500 d to rotate from the second rotational position R2 to the third rotational position R3 by the second indexing ring engaging finger 469 traveling along the third secondary track segment 554. After traveling along the third secondary track segment 554, the second indexing ring engaging finger 469 travels along the fourth secondary track segment 555, as shown in FIG. Figure 13 As shown in I.

[0267] Rotation of the indexing ring 500d to the third rotational position R3 allows the second indexing ring engagement finger 469 to pass the release arm 580 in the proximal direction after the device is removed from the injection site. Figure 13 J. The distal end of the cover locking tab 431 now locks the first needle safety cover 410d in the extended proximal position, ie the final locking position PnsFL. Figure 13 Distal movement of the release member 1006 shown in K rotates the indexing ring 500d back to the first rotational position R1 and the cartridge 100d is now removed from the autoinjector.

[0268] Figure 14A -G shows a close-up of the interaction between the first needle safety cover 410d, the second needle safety cover 440d, the indexing ring 500d and the syringe holder 300d during the process of installing the needle assembly 220 into the syringe holder 300d. Figure 14A In FIG-B (shown from a different direction), the cartridge 100d is in its home position before being installed in the autoinjector. The release arm 580 is positioned in the indexing ring receiving opening 310 and between the first indexing ring engaging finger 433 and the ramp 439 on the first needle safety cover arm 434. The second needle safety cover interface 468 on the second needle safety cover 440d is positioned in the indexing ring receiving opening 310. Figure 14A It can also be seen that it is positioned against the release arm 580. Figure 14BThe first needle safety cover interface 435 and the distal second needle safety cover locking tab 467 can be seen in the figure.

[0269] When the cartridge 100d has been locked in the autoinjector 1000 and the indexing ring 500d is rotationally released from the syringe holder 300d by proximal movement of the release member 1006 in the autoinjector, as shown in FIG. Figure 13 As shown in FIG. 4B , the first needle safety cover 410d can be moved distally relative to the second needle safety cover 440d. As the ramp 439 on the first needle safety cover arm 434 abuts against the release arm 580 on the indexing ring 500d, this causes the indexing ring 500d to rotate slightly. This moves the system to Figure 14C The position shown in the figure is Figure 13 Close-up of the position shown in C. Needle assembly 220 can now be attached.

[0270] exist Figure 14D -F (illustration shown from a different direction), the needle assembly is attached. When doing so, the first needle safety cover 410d and the second needle safety cover 440d are moved further distally. As the second indexing ring engagement finger 469 travels in the second track 544 against the first sub-track 550 and the second sub-track 552 of the second track 544, this rotates the indexing ring 500d to the second rotational position R2. This moves the system to Figure 13 Position shown in D. Needle assembly 220 is now attached.

[0271] As the second indexing ring engagement finger 469 travels in the secondary track 552 of the second track 544, the indexing ring 500d rotates to the second rotational position R2. The rotation of the indexing ring 500d moves the release arm 580 out of engagement with the first indexing ring engagement finger 433. When the needle cap 228 is removed, the first needle safety cover 410d moves proximally relative to the second needle safety cover 440d due to the cover spring 470 pushing the two cover components away from each other. The two needle safety covers 410d, 440d are now locked in the extended position, as shown in FIG. Figure 13 E. Proximal locking of the two needle safety covers 410d, 440d is achieved by the first needle safety cover interface 435 and the distal second needle safety cover locking tab 467.

[0272] Figure 15A -B shows the autoinjector 1000 in an assembled view, and Figure 16An exploded view of an autoinjector 1000 configured to receive cartridges 100, 100b, 100c, 100d is shown. All of the examples of cartridges 100, 100b, 100c, 100d described above can be received in the autoinjector 1000. Different cartridge types can also be received in the autoinjector 1000. The autoinjector 1000 extends along a longitudinal axis L from a proximal end 1002 to a distal end 1004 and includes a syringe housing 1040 and a plurality of internal syringe components positioned within the syringe housing 1040.

[0273] The cartridge 100, 100b, 100c, 100d is removably received in the autoinjector 1000 along the longitudinal axis L. Typically, the cartridge 100, 100b, 100c, 100d will be received at the proximal end 1002 of the autoinjector 1000, making it a front-loading autoinjector. Figure 15B , the view of the interior of the syringe 1000 shows the cartridge abutment surface 1042 against which the cartridge 100, 100b, 100c, 100d abuts when the cartridge is assembled in the syringe 1000. The view shows openings in the cartridge abutment surface 1042 through which internal syringe components extend during the delivery of the medicament and the preparatory steps leading to the delivery of the medicament. The openings include a cartridge detection pin opening 1081 through which the cartridge detection pin 1080 extends. The openings also include a needle safety cover pin opening 1028 through which the syringe needle safety cover pin 1024 extends. A release member opening 1043 through which the release member 1006 extends is also present in the cartridge abutment surface 1042. In Figure 15B Also visible in FIG. 1 are cartridge locking tabs 1086 on the inside of the syringe housing 1040 for securing the cartridge 100 within the autoinjector 1000 .

[0274] like Figure 16 As best seen in the figure, the internal syringe components include a plunger rod 1018 configured for proximal movement to deliver the medicament. The plunger rod 1018 has an internal threaded surface that threadably engages an external threaded surface of a threaded rod 1014 positioned within the plunger rod 1018. When the threaded rod 1014 within the plunger rod 1018 rotates, the plunger rod 1018 moves in either a proximal or distal direction along the longitudinal axis L, depending on how the threaded rod 1014 rotates.

[0275] The autoinjector 1000 includes a release member 1006 having two release member pins 1007, each having a track guide protrusion 1008. When the autoinjector 1000 is activated after the cartridge 100, 100b, 100c, 100d is installed in the autoinjector, the release member 1006 travels within the indexing ring track 514, thereby rotating the indexing ring 500. The release member pins 1007 are connected to the plunger rod opening 1012 via a release member bridge 1010, thereby allowing the plunger rod 1018 to pass through for medicament delivery.

[0276] The release member 1006 and the plunger rod 1018 are connected to a clutch 1030 that is configured to move between a first clutch position in which the plunger rod 1018 and the one or more release members 1006 are longitudinally coupled for proximal movement together, and a second clutch position in which the plunger rod 1018 is disengaged from the one or more release members 1006, thereby allowing the plunger rod 1018 to move longitudinally while the one or more release members 1006 are longitudinally stationary.

[0277] The autoinjector 1000 also includes a syringe needle safety cover pin 1024 and a needle safety cover spring system 1026 that urges the syringe needle safety cover pin 1024 proximally. When the cartridge 100, 100b, 100c, 100d is installed in the autoinjector 1000, the syringe needle safety cover pin 1024 will urge the second needle safety cover 440 proximally while the needle safety cover 440 is free to move proximally, and the user will not simultaneously depress it distally. Typically, the syringe needle safety cover pin 1024 will abut one of the distally extending pins 454 in the needle safety cover 440.

[0278] Also present inside the autoinjector 1000 is a cartridge detection pin 1080 and cartridge detection spring 1082 which detect when a cartridge 100 , 100 b , 100 c , 100 d has been installed in the autoinjector 1000 by contacting the other distally extending pin 454 in the needle safety cover 440 .

[0279] like Figure 15A , the syringe housing 1040 has a distal housing section 1044 that covers the internal syringe components and a proximal cartridge covering section 1046 that at least partially covers the cartridge 100, 100b, 100c, 100d when installed in the autoinjector 1000. When the cartridge 100, 100b, 100c, 100d is installed in the autoinjector 1000, the distal end 104 of the cartridge 100, 100b, 100c, 100d abuts a cartridge abutment surface 1042 on the interior of the autoinjector 1000.

[0280] The internal syringe components also include a drive module adapted to move the plunger rod 1018 proximally. The drive module can be configured in a variety of ways, Figure 16 The solution shown in is just one example of this approach. Figure 16 The drive module shown in the figure includes a motor 1076 and a motor gear 1078 for rotating the threaded rod 1014 within the plunger rod 1018, a battery 1056 (e.g., rechargeable from a USB charger connected to the printed circuit board 1054), and a plurality of base structural components 1070, 1077, 1090, 1094, 1095 and a screw 1079 for supporting the drive module components.

[0281] The autoinjector 1000 may also include a processor that controls the drive module, the processor including a printed circuit board (PCB) 1054. A visual indication to the user may be included in the form of a light emitting diode (LED) 1064, which may be located on a PCB placeholder 1062 or the like. The LED is displayed via the LED window frame 1050, the light box placeholder 1058, and the light guide placeholder 1060.

[0282] The autoinjector can be activated by pressing an activation button 1052 located on the user interface housing component 1048. Typically, a protective foil 1049 is included to protect the electronic components inside the injector 1000. For other internal injector components, reference is made to the list of reference numerals.

[0283] The invention is further described in the following items:

[0284] 1. A cartridge (100, 100d) for use in an autoinjector for administering a medicament, wherein the cartridge extends in a longitudinal direction (L) from a proximal end (102) to a distal end (104), and comprises:

[0285] a syringe holder (300, 300d) configured to receive a syringe (200, 200d) containing the medicament, the syringe (200, 200d) comprising a seal (208) at a proximal end (202) of the syringe (200, 200d), the seal (208) being configured to be pierced by a needle (222) to obtain fluid communication between the medicament in the syringe (200, 200d) and the needle (222);

[0286] wherein the syringe holder (300, 300d) includes a needle assembly securing feature (306) at a proximal end (302) of the syringe holder (300, 300d), wherein the needle assembly securing feature (306) is configured to secure a needle assembly (220) including the needle (222) to the syringe holder (300, 300d) after the cartridge (100, 100d) is installed in the autoinjector (1000);

[0287] ●First needle safety cover (410, 410d);

[0288] a second needle safety cover (440, 440d), wherein the first needle safety cover (410, 410d) is displaceable relative to the second needle safety cover (440, 440d) along the longitudinal direction (L); and

[0289] One or more release arms (480, 580), wherein the one or more release arms (480, 580) are movable between at least two positions relative to the syringe holder (300, 300d), the at least two positions comprising:

[0290] ○ Initial position (PraIN), in which the first needle safety cover (410,

[0291] 410d) and said second needle safety cover (440, 440d) are separated by at most a first separation distance; and

[0292] o Release position (PraR), in which the first needle safety cover (410,

[0293] 410d) and the second needle safety cover (440, 440d) move relative to each other to a second separation distance greater than the first separation distance.

[0294] 2. The cartridge according to item 1, wherein in the initial position (PraIN), the first needle safety cover (410, 410d) is prevented from moving proximally relative to the second needle safety cover (440, 440d).

[0295] 3. The cartridge according to any of the preceding items, wherein in the release position (PraR), the first needle safety cover (410, 410d) is allowed to move proximally relative to the second needle safety cover (440, 440d).

[0296] 4. A box according to any of the preceding items, wherein the box (100, 100d) further includes one or more cover springs (470), and the one or more cover springs are biased between the first needle safety cover (410, 410d) and the second needle safety cover (440, 440d).

[0297] 5. A box according to item 4, wherein the needle assembly (220) further includes a removable needle cap (228) that covers and protects the needle (222) before use, wherein after the needle assembly (220) is secured to the syringe holder (300, 300d) and the needle cap (228) is removed, the one or more cover springs (470) are suitable for pushing the first needle safety cover (410, 410d) in the proximal direction relative to the second needle safety cover (440, 440d), thereby the first needle safety cover (410, 410d) covers the needle (222) in the ready to use position (PnsR).

[0298] 6. The cassette according to any of the preceding items, wherein the first needle safety cover (410, 410d) is movable between a plurality of longitudinal positions relative to the syringe holder (300, 300d), the plurality of longitudinal positions comprising:

[0299] ●Ready to use position (PnsR);

[0300] a drug delivery position (PnsD) at which the needle (222) is exposed, wherein the drug delivery position (PnsD) is distal to the ready-to-use position (PnsR);

[0301] A final locking position (PnsFL) in which further longitudinal movement of the first needle safety cover (410) is prevented, wherein the final locking position (PnsFL) is proximal to the medicament delivery position (PnsD).

[0302] 7. The cartridge according to item 6, wherein the first needle safety cover (410, 410d) covers the needle (222) in the ready to use position (PnsR).

[0303] 8. The cartridge according to item 6 or 7, wherein said final locking position (PnsFL) is proximal to said ready-to-use position (PnsR).

[0304] 9. The cartridge according to any of the preceding items, wherein the second needle safety cover (440, 440d) also serves as a needle mounting blocking system (400) configured to move between the following positions:

[0305] a locked position (PnsL) that prevents puncture of the seal (208) by the needle (222) before the cartridge (100, 100d) is secured in the autoinjector (1000); and

[0306] a needle assembly connection position (PnsC) that allows the seal (208) to be pierced by the needle (222) after the cartridge (100, 100d) is secured in the autoinjector (1000);

[0307] The movement of the second needle safety cover (440, 440d) is configured to be controlled by the auto-injector (1000) after the cartridge (100, 100d) is secured in the auto-injector (1000).

[0308] 10. The cartridge according to item 9, wherein the needle assembly connection position (PnsC) is distal to the locking position (PnsL).

[0309] 11. A box according to any one of items 9-10, wherein after the box (100, 100d) is fixed in the automatic injector (1000), the second needle safety cover (440, 440d) is configured for longitudinal unlocking, whereby the second needle safety cover (440, 440d) can be moved in the distal direction relative to the syringe holder (300, 300d), thereby moving the second needle safety cover (440, 440d) to the needle assembly connection position (PnsC), thereby allowing the needle assembly (220) to be fixed to the syringe holder (300, 300d).

[0310] 12. A box according to item 11, wherein after the box (100, 100d) is fixed in the automatic injector (1000), the first needle safety cover (410, 410d) and the one or more cover springs (470) are configured for longitudinal unlocking, whereby the first needle safety cover (410, 410d) and the one or more cover springs (470) are able to move in the distal direction relative to the syringe holder (300, 300d).

[0311] 13. A box according to any of the preceding items, wherein the needle assembly fixing component (306) fixes the needle assembly (220) to the proximal end (302) of the syringe holder (300, 300d) by a threaded connection, a press fit connection, a snap fit connection, a bayonet connection, or a combination of these.

[0312] 14. The cassette according to any of the preceding items, wherein the cassette (100, 100d) further comprises an indexing ring (500, 500d) rotatable relative to the first needle safety cover (410, 410d) between a plurality of rotational positions, the plurality of rotational positions comprising at least:

[0313] a first rotational position (R1) in which the second needle safety cover (440, 440d) is prevented from distal movement; and

[0314] a second rotational position (R2), in which the second needle safety cover (440, 440d) is able to move longitudinally;

[0315] wherein movement of one or more release members (1006) in the autoinjector allows rotation of the indexing ring (500, 500d) when the cartridge (100, 100d) is secured in the autoinjector (1000).

[0316] 15. The cartridge of item 14, wherein the indexing ring (500, 500d) comprises a first track (514) extending from a first corner (516) to a second corner (518) of a surface area of ​​the indexing ring (500, 500d).

[0317] 16. A box according to item 15, wherein the first track (514) extends from the first corner (516) toward the second corner (518) in an angled direction, wherein the angled direction is between 20 degrees and 70 degrees relative to the longitudinal direction of the box, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees.

[0318] 17. The cartridge of item 16, wherein the first track (514) comprises a first track section (520) and a second track section (522), wherein:

[0319] o The first track segment (520) extends in a first angular direction from the first corner (516) toward a first midpoint (526);

[0320] o the second track segment (522) extends in a second angular direction along the longitudinal direction of the box from the first midpoint (526) to a second midpoint (528);

[0321] wherein the first angled direction is between 20 and 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees, relative to the longitudinal direction of the cartridge, and

[0322] Wherein the second angled direction is between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box.

[0323] 18. A box according to item 17, wherein the first track (514) also includes a third track segment (524), wherein the third track segment (524) extends from the second midpoint (528) toward the second corner (518) in a third angled direction, wherein the third angled direction is between 20 degrees and 70 degrees relative to the longitudinal direction of the box, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees.

[0324] 19. A box according to any one of items 14-18, wherein after the delivery of the drug, distal movement of the one or more release members (1006) causes the indexing ring (500, 500d) to rotate back to the first rotational position (R1), whereby the first needle safety cover (410, 410d) is longitudinally locked in the final locking position (PnsFL).

[0325] 20. A box according to any one of items 6-19, wherein the first needle safety cover (410, 410d) includes one or more cover locking tabs (431), which lock the first needle safety cover (410, 410d) in the final locking position (PnsFL) by preventing the first needle safety cover (410, 410d) from moving distally relative to the box housing (600, 600d).

[0326] 21. A box according to any of the preceding items, wherein the needle assembly (220) is pre-installed at the first needle safety cover ((410, 410d)) before use, and wherein the fluid connection between the syringe (200, 200d) and the needle (222) is obtained by distal movement of the needle assembly (220), the second needle safety cover (440, 440d) and the first needle safety cover (410, 410d) relative to the syringe (410, 410d), and the distal movement may be combined with a rotational movement of the needle assembly (220) relative to the syringe (200, 200d).

[0327] 22. The cartridge according to any one of items 14-21, wherein the release arm (580) is part of the indexing ring (500d).

[0328] 23. The cartridge of item 22, wherein the release arm (580) is positioned at the proximal end (502) of the indexing ring (500d).

[0329] 24. The cassette of any of items 14-23, wherein the first needle safety cover (410d) includes a first indexing ring engaging finger (433), and the second needle safety cover (440d) includes a second indexing ring engaging finger (469);

[0330] wherein when the indexing ring (500d) is in the first rotational position (R1), the first indexing ring engagement finger (433) and the second indexing ring engagement finger (469) abut at least one of the one or more release arms (580) on the indexing ring (500d), thereby preventing proximal movement of the first needle safety cover (410d) and the second needle safety cover (440d) relative to the indexing ring (500d); and

[0331] Wherein, when the indexing ring (500d) is in the second rotational position (R2), the first indexing ring engaging finger (433) no longer abuts at least one of the one or more release arms (580) on the indexing ring (500d), whereby the one or more cover springs (470) are configured to move the first needle safety cover (410d) proximally relative to the second needle safety cover (440d).

[0332] 25. A box according to item 24, wherein when the indexing ring (500d) is in the second rotational position (R2), the one or more cover springs (470) cause the first needle safety cover (410d) to move proximally relative to the second needle safety cover (440d) to a locked cover position, in which further relative longitudinal movement between the first needle safety cover (410d) and the second needle safety cover (440d) is prevented by one or more locking devices.

[0333] 26. A box according to item 25, wherein the one or more locking devices include a first locking pair (435, 467), wherein the first needle safety cover (410d) and the second needle safety cover (440d) include the first locking pair (435, 467), and the first locking pair prevents proximal movement of the first needle safety cover (410d) relative to the second needle safety cover (440d).

[0334] 27. A box according to item 25 or 26, wherein the one or more locking devices include a second locking pair (436, 466), wherein the first needle safety cover (410d) and the second needle safety cover (440d) include the second locking pair (436, 466), and the second locking pair prevents distal movement of the first needle safety cover (410d) relative to the second needle safety cover (440d).

[0335] 28. A box according to any one of items 14-27, wherein the indexing ring (500d) includes a second track (544) extending from a first secondary corner (546) to a second secondary corner (548) of a surface area of ​​the indexing ring (500d), wherein the indexing ring (500d) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) by distal movement of the second needle safety cover (440d), whereby the second indexing ring engaging finger (469) on the second needle safety cover (440d) travels within the second track (544), thereby rotating the indexing ring (500d).

[0336] 29. The cartridge of item 28, wherein the second track (544) comprises a first sub-track segment (550) and a second sub-track segment (552), wherein:

[0337] o The first secondary track segment (550) extends in a first secondary angular direction from the first secondary corner (546) toward a first secondary midpoint (526);

[0338] o The second secondary track segment (552) extends from the first secondary midpoint (556) to a second secondary midpoint (558) in a second secondary angular direction along the longitudinal direction of the box;

[0339] wherein the first pair of angled directions is between 20 and 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees, relative to the longitudinal direction of the cartridge, and

[0340] Wherein the second pair of angled directions is between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box.

[0341] 30. A box according to item 29, wherein the second track (544) further includes a third sub-track segment (554), wherein the third sub-track segment (554) extends from the second sub-midpoint (558) toward the second sub-corner (548) in a third sub-angled direction, wherein the third sub-angled direction is between 20 degrees and 70 degrees relative to the longitudinal direction of the box, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees.

[0342] 31. A box according to any one of items 14-30, wherein the box further comprises one or more indexing ring release tabs (330) capable of moving relative to the indexing ring (500d), wherein when the box (100d) is fixed in the automatic injector (1000), one or more release members (1006) of the automatic injector move to a first release member position within the box (100d), causing the one or more indexing ring release tabs (330d) to move from the initial position (PraIN) to the release position (PraR).

[0343] 32. The cartridge of item 31, wherein the one or more indexing ring release tabs (330) are part of the syringe holder (300d).

[0344] 33. The cartridge of any of items 31-32, wherein the one or more indexing ring release tabs (330) comprise a protruding surface (332) that engages a blocking surface (540) on the indexing ring (500d) in the initial position (PraIN) thereby preventing the indexing ring (500d) from rotating from the first rotational position (R1) to the second rotational position (R2);

[0345] wherein the one or more indexing ring release tabs (330) are configured to be deflected radially inwardly by proximal movement of the one or more release members (1006) when the cartridge (100d) is secured in the autoinjector (1000);

[0346] wherein when the one or more indexing ring release tabs (330) are deflected radially inwardly, the protruding surface (332) no longer engages the blocking surface (540) on the indexing ring (500d), thereby enabling the indexing ring (500d) to rotate from the first rotational position (R1) to the second rotational position (R2).

[0347] 34. A box according to item 33, wherein the indexing ring (500d) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) by distal movement of the first needle safety cover (410d) when the protruding surface (332) no longer engages the blocking surface (540) on the indexing ring (500d).

[0348] 35. A box according to item 33 or 34, wherein the indexing ring (500d) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) by the second indexing ring engaging finger (469) on the second needle safety cover (440d) moving within the first sub-track section (550) on the indexing ring (500d).

[0349] 36. A box according to any one of items 31-35, wherein when the one or more release members (1006) are in the first release member position within the box (100d), further rotation of the indexing ring (500d) from the second rotational position (R2) to the third rotational position (R3) is prevented by the one or more release members (1006) engaging the first track (514) in the indexing ring (500d).

[0350] 37. A box according to item 34, wherein when the one or more release members (1006) of the automatic syringe move further proximally from the first release member position within the box (100d) to the second release member position within the box (100d), the dividing ring (500d) is capable of rotating from the second rotational position (R2) to the third rotational position (R3), and the second release member position is proximal to the first release member position.

[0351] 38. A box according to item 37, wherein the indexing ring (500d) is configured to rotate from the second rotational position (R2) to the third rotational position (R3) by distal movement of the first needle safety cover (410d) after the one or more release members (1006) of the automatic injector move proximally from the first release member position within the box (100d) to the second release member position within the box (100d).

[0352] 39. A box according to item 37 or 38, wherein the indexing ring (500d) is configured to rotate from the second rotational position (R2) to the third second rotational position (R3) by the second indexing ring engaging finger (469) on the second needle safety cover (440d) moving within the third sub-track section (554) on the indexing ring (500d).

[0353] 40. A box according to any one of items 34-39, wherein when the indexing ring (500d) is in the third second rotational position (R3), the second indexing ring engaging finger (469) no longer abuts at least one of the one or more release arms (580) on the indexing ring (500d), thereby allowing the first needle safety cover (410d) and the second needle safety cover (440d) to move proximally relative to the indexing ring (500d) to a final locked position.

[0354] 41. A box according to item 40, wherein the first needle safety cover (410d) includes one or more housing locking components, which lock the first needle safety cover (410d) in the final locking position by preventing the first needle safety cover (410d) from moving distally relative to the box housing (600d).

[0355] 42. A box according to any of items 4-19, wherein the first needle safety cover (410) and the second needle safety cover (440) are allowed to move toward each other by compression of the one or more cover springs (470) before the box (100) is secured in the automatic injector (1000).

[0356] 43. A cartridge according to any one of items 4-19 and 42, wherein the one or more release arms are separate components that do not form part of the indexing ring (500), the second needle safety cover (440) and the first needle safety cover (410).

[0357] 44. A box according to any one of items 4-19 and 42-43, wherein the second needle safety cover (440) includes at least one flexible arm (446), and the first needle safety cover (410) includes a first locking tab (416), and the one or more release arms (480) each include a protruding surface release member (486), wherein the protruding surface release member (486) limits proximal movement of the first needle safety cover (410) relative to the second needle safety cover (440) in the initial position (PraIN) by preventing the at least one flexible arm (446) from flexing when adjacent to the first locking tab (416).

[0358] 45. A box according to any one of items 4-19 and 42-44, wherein when the needle assembly (220) is secured to the syringe holder (300), the second needle safety cover (440), the first needle safety cover (410) and the one or more release arms (480) are configured to move distally relative to the syringe holder (300).

[0359] 46. ​​A box according to item 45, wherein when the needle assembly (220) is secured to the syringe holder (300), each of the second needle safety cover (440), the first needle safety cover (410) and the one or more release arms (480) moves distally a different distance relative to the syringe holder (300).

[0360] 47. A cartridge according to any one of items 4-19 and 42-46, wherein the one or more release arms (480) are locked relative to the syringe holder (300) after the needle assembly (220) is secured to the syringe holder (300).

[0361] 48. A box according to item 47, wherein when the one or more release arms (480) are in the release position (PraR) after the needle assembly (220) is secured to the syringe holder (300) and the needle cap (228) is removed, the second needle safety cover (440) is suitable for being moved proximally by the automatic injector (1000) while the one or more release arms (480) are locked relative to the syringe holder (300).

[0362] 49. A box according to any one of items 47-48 that are subordinate to any one of items 44-46, wherein items 44-46 are subordinate to any one of items 4-19 and 42-43, wherein when the one or more release arms (480) are in the release position (PraR) after the needle assembly (220) is fixed to the syringe holder (300) and the needle cap (228) is removed, the one or more cover springs (470) are suitable for pushing the first needle safety cover (410) in the proximal direction relative to the second needle safety cover (440), thereby causing the at least one flexible arm (446) to move proximally and enter the flexed position of the at least one flexible arm (446) through the protruding surface release part (486), thereby allowing the first locking tab (416) of the first needle safety cover (410) to pass through the at least one flexible arm (446), thereby using the one or more cover springs (470) to push the first needle safety cover (410) to the extended position relative to the second needle safety cover (440).

[0363] 50. A box according to any one of items 46-49, wherein when the box is in the ready to use position (PnsR), the one or more release arms (480) are in the release position (PraR) and the needle safety cover components (410, 440) are in a locked cover position, in which further relative longitudinal movement of the first needle safety cover (410) relative to the second needle safety cover (440) is prevented.

[0364] 51. A box according to item 50, wherein the first needle safety cover (410) includes a second locking tab (420) positioned distal to the first locking tab (416), and the second needle safety cover (440) includes a stop surface (450) positioned proximal to the flexible arm (446), wherein in the locked cover position, the second locking tab (420) abuts the flexible arm (446) thereby preventing distal movement of the first needle safety cover (410) relative to the second needle safety cover (440), and the first locking tab (416) abuts the stop surface (450) thereby preventing proximal movement of the first needle safety cover (410) relative to the second needle safety cover (440).

[0365] 52. The cartridge of any one of items 4-19 and 42-51, wherein movement of one or more release members (1006) in the autoinjector causes the indexing ring (500) to rotate when the cartridge (100) is secured in the autoinjector (1000).

[0366] 53. A box according to any one of items 4-19 and 42-52, wherein the indexing ring (500) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) when the box (100) is inserted into the automatic injector (1000) and the one or more release members (1006) included in the automatic injector (1000) move proximally within the track (514).

[0367] 54. A system for use in an automatic injector for administering a medicament, the system comprising:

[0368] ● A cartridge (100, 100d) according to any one of items 1-53; and

[0369] a syringe (200, 200d) comprising a syringe compartment (206, 206d) containing the medicament and a seal (208) at a proximal end (202) of the syringe (200, 200d), the seal (208) being configured to be pierced by a distal end of a needle (222) to obtain fluid communication between the medicament in the syringe (200, 200d) and the needle (222);

[0370] The first needle safety cover (410, 100d) prevents the distal end of the needle (222) from piercing the seal (208) before the cartridge (100, 100d) is secured in the autoinjector (1000).

[0371] 55. The system according to item 54, wherein the syringe compartment (206d) comprises:

[0372] A first sub-compartment (214) containing a first pharmaceutical component;

[0373] A second sub-compartment (216) containing a second pharmaceutical component;

[0374] a bypass region (217) positioned between the first sub-compartment (214) and the second sub-compartment (216);

[0375] • a first stopper (212) positioned distally in said first sub-compartment (214) prior to use; and

[0376] • a second stopper (218) positioned between the first sub-compartment (214) and the second sub-compartment (216) prior to use;

[0377] Wherein, when the first stop member (212) moves in the proximal direction, the first drug component moves proximally, thereby causing the second stop member (218) to move proximally, thereby allowing the first drug component to enter the second sub-compartment (216) through the bypass area (217), thereby mixing the first drug component and the second drug component.

[0378] 56. The system according to item 55, wherein the indexing ring (500, 500d) is in the second rotational position (R2) when the first medicament component and the second medicament component are mixed.

[0379] 57. A system according to any one of items 54-56, wherein the system further comprises a needle assembly (220), the needle assembly comprising the needle (222), a needle assembly adapter (226) for securing the needle assembly (220) to the syringe holder (300), and a removable needle cap (228) covering and protecting the needle (222), wherein the proximal end of the needle (222) is configured to pierce the seal (208) of the syringe (200, 200d), and the proximal end of the needle (222) is configured to pierce an injection site.

[0380] 58. The system according to any one of items 54-57, further comprising the autoinjector (1000), wherein the autoinjector (1000) is configured to receive the cartridge (100, 100d).

[0381] 59. An automatic injector (1000) for administering a medicament, the automatic injector (1000) being configured to receive, without modification, any of the cartridges (100, 100d) according to items 1-53 and / or any of the systems according to items 54-57.

[0382] 60. An automatic injector (1000) according to item 59, wherein the automatic injector (1000) includes one or more release members (1006), which are configured to move into the box (100, 100d) when the box has been received in the automatic injector (1000).

[0383] 61. A cartridge (100, 100d) for use in an autoinjector for administering a medicament, wherein the cartridge extends in a longitudinal direction (L) from a proximal end (102) to a distal end (104), and comprises:

[0384] Needle safety cover (400, 410, 410d, 440, 440d);

[0385] An indexing ring (500, 500d) rotatable relative to the needle safety cover (400, 410, 410d, 440, 440d) between a plurality of rotational positions, the plurality of rotational positions comprising at least:

[0386] ○ A first rotational position (R1), in which the needle is prevented from being secured

[0387] The cover (400, 410, 410d, 440, 440d) moves distally; and

[0388] ○ The second rotation position (R2), in which the needle safety cover (400,

[0389] 410, 410d, 440, 440d) capable of longitudinal movement;

[0390] a syringe holder (300, 300d) configured to receive a syringe (200, 200d) containing the medicament, the syringe (200, 200d) comprising a seal (208) at a proximal end (202) of the syringe (200, 200d), the seal (208) being configured to be pierced by a needle (222) to obtain fluid communication between the medicament in the syringe (200, 200d) and the needle (222);

[0391] wherein the syringe holder (300, 300d) includes a needle assembly securing feature (306) at a proximal end (302) of the syringe holder (300, 300d), wherein the needle assembly securing feature (306) is configured to secure a needle assembly (220) including the needle (222) to the syringe holder (300, 300d) after the cartridge (100, 100d) is installed in the autoinjector (1000);

[0392] One or more indexing ring release tabs (330, 330d) movable relative to the indexing ring (500, 500d) between at least two positions, the at least two positions comprising:

[0393] an initial position (PraIN) in which the indexing ring (500, 500d) is prevented from rotating from the first rotational position (R1) to the second rotational position (R2); and

[0394] a release position (PraR), in which the indexing ring (500, 500d) is rotatable from the first rotational position (R1) to the second rotational position (R2);

[0395] wherein when the cartridge (100, 100d) is secured in the auto-injector (1000), movement of the one or more release members (1006) of the auto-injector to a first release member position within the cartridge (100, 100d) causes the one or more indexing ring release tabs (330) to move from the initial position (PraIN) to the release position (PraR).

[0396] 62. The cartridge of item 61, wherein when the one or more release members (1006) are in the first release member position within the cartridge (100, 100d), the indexing ring (500, 500d) is prevented from rotating from the second rotational position (R2) by the one or more release members (1006) engaging a first track (514) in the indexing ring (500, 500d).

[0397] Further rotation to a third rotational position (R3).

[0398] 63. The cartridge of any one of items 61-62, wherein the one or more indexing ring release tabs (330) are part of the syringe holder (300, 300d).

[0399] 64. A cartridge according to any of items 61-63, wherein the one or more indexing ring release tabs (330) comprise a protruding surface (332) that engages a blocking surface (540) on the indexing ring (500, 500d) in the initial position (PraIN) thereby preventing the indexing ring (500, 500d) from rotating from the first rotational position (R1) to the second rotational position (R2);

[0400] wherein the one or more indexing ring release tabs (330) are configured to be deflected radially inwardly by proximal movement of the one or more release members (1006) when the cartridge (100, 100d) is secured in the autoinjector (1000);

[0401] wherein when the one or more indexing ring release tabs (330) are deflected radially inwardly, the protruding surface (332) no longer engages the blocking surface (540) on the indexing ring (500, 500d), thereby enabling the indexing ring (500, 500d) to rotate from the first rotational position (R1) to the second rotational position (R2).

[0402] 65. A cartridge according to any one of items 61-64, wherein the indexing ring (500, 500d) is rotatable from the first rotational position (R1) to the second rotational position (R2) by distal movement of the needle safety cover (400, 410, 410d, 440, 440d).

[0403] 66. A cartridge according to any one of items 61-65, wherein the indexing ring (500, 500d) comprises a second track (544) extending from a first minor corner (546) to a second minor corner (548) of a surface area of ​​the indexing ring (500, 500d), wherein the indexing ring (500, 500d) is configured to be rotated from the first rotational position (R1) to the second rotational position (R2) by distal movement of the needle safety cover (400, 410, 410d, 440, 440d), whereby at least one protrusion on the needle safety cover (400, 410, 410d, 440, 440d) travels within the second track (544), thereby causing the indexing ring (500, 500d) to rotate from the first rotational position (R1) to the second rotational position (R2)

[0404] Rotate.

[0405] 67. A cartridge according to any one of items 61-66, wherein the needle safety cover (400, 410,

[0406] 410d, 440, 440d) are configured to move between the following positions:

[0407] A locked position (PnsL) which prevents the cartridge (100, 100d) from being opened.

[0408] piercing the seal (208) by the needle (222) prior to being secured in the autoinjector (1000); and

[0409] a needle assembly connection position (PnsC) that allows the seal (208) to be pierced by the needle (222) after the cartridge (100, 100d) is secured in the autoinjector (1000);

[0410] wherein when the indexing ring (500, 500d) is in the first rotational position (R1), the needle safety cover (400, 410, 410d, 440, 440d) is in the locked position (PnsL), and

[0411] When the indexing ring (500, 500d) is in the second rotation position (R2), the needle safety cover (400, 410, 410d, 440, 440d) can move to the needle assembly connection position (PnsC) by distally moving the needle safety cover (400, 410, 410d, 440, 440d).

[0412] 68. A cartridge according to any one of items 61-67, wherein the needle safety cover (400, 410,

[0413] 410d, 440, 440d) include:

[0414] A needle safety cover (410, 410d); and

[0415] ●A second needle safety cover (440, 440d), wherein the first needle safety cover (410, 410d) is capable of being shifted along the longitudinal direction relative to the second needle safety cover (440, 440d), wherein in the initial position (PraIN), the first needle safety cover (410, 410d) and the second needle safety cover (440, 440d) are separated by at most a first separation distance, and wherein in the release position (PraR), the first needle safety cover (410, 410d) and the second needle safety cover (440, 440d) are allowed to move relative to each other to a second separation distance greater than the first separation distance.

[0416] 69. The cassette of item 68, wherein the cassette (100d) further comprises one or more cover springs (470) biased between the first needle safety cover (410d) and the second needle safety cover (440d);

[0417] wherein the first needle safety cover (410d) includes a first indexing ring engaging finger (433), and the second needle safety cover (440d) includes a second indexing ring engaging finger (469);

[0418] wherein when the indexing ring (500d) is in the first rotational position (R1), the first indexing ring engagement finger (433) and the second indexing ring engagement finger (469) on the second needle safety cover (440d) abut at least one of the one or more release arms (580) on the indexing ring (500d), thereby preventing proximal movement of the first needle safety cover (410) and the second needle safety cover (440) relative to the indexing ring (500d); and

[0419] wherein when the indexing ring (500d) is in the second rotational position (R2), the first indexing ring engaging finger (433) no longer abuts at least one of the one or more release arms (580) on the indexing ring (500d), whereby the one or more cover springs (470) are configured to move the first needle safety cover (410d) proximally relative to the second needle safety cover (440d), thereby moving the first needle safety cover (410d) to a locked cover position in which the first needle safety cover is prevented from being released.

[0420] (410d) and the second needle safety cover (440d) further relative longitudinal movement between.

[0421] 70. The cartridge of item 69, wherein the first needle safety cover (410d) and the second needle safety cover (440d) comprise a first locking pair (435, 467) and a second locking pair (436, 466), wherein in the locked cover position, the first locking pair prevents the first needle safety cover (410d) from

[0422] Relative to proximal movement of the second needle safety cover (440d), the second locking pair prevents distal movement of the first needle safety cover (410d) relative to the second needle safety cover (440d).

[0423] 71. A box according to any of items 66-70, wherein the second track (544) comprises

[0424] A first secondary track segment (550) and a second secondary track segment (552), wherein:

[0425] o The first secondary track segment (550) extends in a first secondary angular direction from the first secondary corner (546) toward a first secondary midpoint (526);

[0426] The second secondary track segment (552) extends from the first secondary midpoint (556) to a second secondary midpoint (558) along the longitudinal direction of the box in a second secondary angular direction; wherein the first secondary angular direction is between 20° and 100° relative to the longitudinal direction of the box.

[0427] degrees and 70 degrees, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees

[0428] degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees, and

[0429] The second pair of angles is between -20 and -20 degrees relative to the longitudinal direction of the box.

[0430] degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees.

[0431] 72. The box according to item 71, wherein the second track (544) further includes a third secondary track segment (554), wherein the third secondary track segment (554) extends from the second secondary midpoint (558) toward the second secondary corner (548) in a third secondary angular direction, wherein the third secondary angular direction is between 20 degrees and 10 degrees relative to the longitudinal direction of the box.

[0432] Between 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees.

[0433] 73. A box according to any one of items 62-72, wherein the indexing ring (500d) is capable of rotating from the second rotational position (R2) to the third rotational position (R3) when the one or more release members (1006) of the automatic syringe move proximally from the first release member position within the box (100d) to the second release member position within the box (100d).

[0434] 74. The cartridge of any one of items 62-73, wherein the indexing ring (500d) is configured for engaging the first secondary track segment (550) on the indexing ring (500d) via the second indexing ring engagement finger (469) on the second needle safety cover (440d).

[0435] The first rotation position (R1) is rotated to the second rotation position (R2) by moving inward.

[0436] 75. A box according to item 73 or 74, wherein the indexing ring (500d) is configured to rotate from the second rotational position (R2) to the third rotational position (R3) by distal movement of the first needle safety cover (410d) after the one or more release members (1006) of the automatic syringe move proximally from the first release member position within the box (100d) to the second release member position within the box (100d).

[0437] 76. A box according to item 75, wherein the indexing ring (500d) is configured to rotate from the second rotational position (R2) to the third second rotational position (R3) by the second indexing ring engaging finger (469) on the second needle safety cover (440d) moving within the third sub-track section (554) on the indexing ring (500d).

[0438] 77. A box according to item 75 or 76, wherein when the indexing ring (500d) is in the third rotational position (R3), the second indexing ring engaging finger (469) no longer abuts at least one of the one or more release arms (580) on the indexing ring (500d), thereby allowing the first needle safety cover (410d) and the second needle safety cover (440d) to move proximally relative to the indexing ring (500d) to a final locked position.

[0439] 78. A box according to item 77, wherein the first needle safety cover (410d) includes one or more housing locking components, which lock the first needle safety cover (410d) in the final locking position by preventing the first needle safety cover (410d) from moving distally relative to the box housing (600d).

[0440] Reference Mark

[0441] 100, 100b, 100c, 100d boxes

[0442] 102, 102b, 102c proximal end of the cartridge 104, 104b, 104c distal end of the cartridge 200, 200d syringe

[0443] 202 Proximal end of syringe

[0444] 204 distal end of the syringe

[0445] 206, 206d syringe compartment

[0446] 208 Seal / Septum at the outlet end of the syringe 209 Syringe outlet

[0447] 212 first stopper

[0448] 214 First Subcompartment

[0449] 216 Second Subcompartment

[0450] 217 Bypass Area

[0451] 218 Second stopper

[0452] 220, 220b needle assembly

[0453] 222, 222b needle

[0454] 224, 224b needle seat

[0455] 226, 226b needle assembly adapter

[0456] 228, 228b Needle cap / rigid needle shield / RNS 232, 232b Proximal end of needle

[0457] 234, 234b distal end of the needle 235b needle assembly shield 236 rigid needle shield, RNS

[0458] 300, 300d syringe holder

[0459] 302 Proximal end of syringe holder

[0460] 304 Distal end of syringe holder

[0461] 306 Needle Assembly Locking Part

[0462] 308 slender tubular parts

[0463] 310 Indexing ring receiving opening

[0464] 312 Window allowing viewing of syringe barrel

[0465] 314 Release arm receiving channel

[0466] 315 Release arm blocking surface

[0467] 316 distal ring component

[0468] 318 plunger opening

[0469] 319 Release member opening

[0470] 320 Box Detection Tab

[0471] 322 syringe support surface

[0472] 324 syringe fixing hook

[0473] 330 Indexing ring release arm on syringe holder

[0474] 332 protruding surface

[0475] 400, 400b Needle Safety Cover Assembly / Needle Mounting Blocking System

[0476] 402, 402b needle safety cover assembly / needle installation barrier system proximal end

[0477] 404b Needle Safety Cap Assembly / Distal End of Needle Mounting Blocking System

[0478] 408 Combination Fully Extended Needle Safety Cover

[0479] 410, 410d first needle safety cover

[0480] 412 Proximal end of first needle safety cover

[0481] 414 Distal end of first needle safety cover

[0482] 416 First locking tab on the first needle safety cover

[0483] 417 Proximal slope of first locking tab

[0484] 418 distal surface of the first locking tab

[0485] 420 Second locking tab on the first needle safety cover

[0486] 421 Proximal slope of the second locking tab

[0487] 422 distal surface of the second locking tab

[0488] 424 Proximally positioned surface plate

[0489] 426 Opening at the proximal end of the first needle safety cover

[0490] 428 inner bearing surface

[0491] 429 Cassette housing guide tab

[0492] 430 Cover Locking Tab

[0493] 431 Distal end of cover locking tab

[0494] 432 distally extending pin

[0495] 433 First indexing ring engagement finger

[0496] 434 First needle safety cover arm

[0497] 435 First pin safety cover interface

[0498] 436 Distal first needle safety cover locking surface

[0499] 437 Proximal first needle safety cover locking surface

[0500] 438 Cartridge housing stop surface

[0501] 439 Slope on the first needle safety cover arm

[0502] 440, 440', 440b, 440d second needle safety cover

[0503] 442 Proximal end of the second needle safety cover

[0504] 444 Distal end of second needle safety cover

[0505] 446 Flexible arm on the second needle safety cover

[0506] 447 distal end of the flexible arm

[0507] 448 Slope on the flexible arm

[0508] 449 Proximal stop surface on flexible arm

[0509] 450 Stop surface of the second needle safety cover

[0510] 452, 452b tubular components

[0511] 454 proximally extending pin

[0512] 456, 456b distally extending pins

[0513] 457, 457b distal end of the pin extending distally

[0514] 458 Inspection Opening

[0515] 460, 460b first locking recess

[0516] 461b second locking recess

[0517] 462, 462b Safety cover locking protrusion / blocking system locking protrusion

[0518] 464, 464b The surface of the distally extending pin

[0519] 465 proximal end surface

[0520] 466 Proximal Second Needle Safety Cover Locking Tab

[0521] 467 Distal Second Needle Safety Cover Locking Tab

[0522] 468 Second pin safety cover interface

[0523] 469 Second indexing ring engagement finger

[0524] 470 cover spring

[0525] 472 Proximal end of cover spring

[0526] 474 distal end of cover spring

[0527] 480 Release Arm

[0528] 482 proximal end of release arm

[0529] 484 Distal end of release arm

[0530] 486 Release arm with raised surface to release component

[0531] 490 flexible fingers

[0532] 500, 500d indexing ring

[0533] 502 Proximal end of indexing ring

[0534] 504 Distal end of indexing ring

[0535] 506 Indexing ring locking protrusion

[0536] 508 Indexing Ring Arm

[0537] 510 Tubular component of indexing ring

[0538] 512 Surface area of ​​indexing ring

[0539] 514 Tracks in the surface area of ​​the indexing ring

[0540] 516 The first corner of the track

[0541] 518 The second corner of the track

[0542] The first section of the 520 track

[0543] 522 The second section of the track

[0544] 524 The third section of the track

[0545] 526 The first midpoint of the track

[0546] 528 The second midpoint of the track

[0547] 540 blocking surface

[0548] 544 Second Track

[0549] 546 First Corner

[0550] 548 Second Corner

[0551] 550 The first sub-track of the second track

[0552] 552 The second sub-track of the second track

[0553] 554 The third sub-track of the second track

[0554] 555 The fourth sub-track of the second track

[0555] 556 The first secondary midpoint of the second track

[0556] 558 The second secondary midpoint of the second track

[0557] 580 Release arm on indexing ring

[0558] 600, 600d box shell

[0559] 602 proximal end of the cartridge housing

[0560] 604 distal end of the cartridge housing

[0561] 606 Housing locking protrusion

[0562] 608 Slope of the housing locking protrusion

[0563] 610 proximal surface of the housing locking protrusion

[0564] 612 opening in the box housing

[0565] 614 Inspection Window

[0566] 616 Box fixing tab

[0567] 618d First needle safety cover stop surface

[0568] 620d First needle safety cover channel

[0569] 1000 Auto-injectors

[0570] 1002 Proximal end of autoinjector

[0571] 1004 Distal end of autoinjector

[0572] 1006 Release component

[0573] 1007 Release member pin

[0574] 1008 Track guide protrusion

[0575] 1010 Release member bridge portion

[0576] 1012 piston rod opening

[0577] 1014 threaded rod

[0578] 1016 Motor and Threaded Rod Connector

[0579] 1018 plunger rod

[0580] 1019 Clutch tab

[0581] 1020 First piston rod plug component

[0582] 1022 Second plunger rod plug member engaging the stopper

[0583] 1024 Syringe Needle Safety Pin

[0584] 1026 Needle Safety Cover Spring System

[0585] 1028 Needle safety cover latch opening in box abutment surface

[0586] 1030 Clutch

[0587] 1032 Switch

[0588] 1040 syringe housing

[0589] 1042 Box Adjacent Surfaces

[0590] 1043 Release member opening in cartridge abutment surface

[0591] 1044 distal shell segment

[0592] 1046 boxes cover the segment

[0593] 1048 first user interface housing component

[0594] 1049 Protective Foil

[0595] 1050 LED window frame

[0596] 1052 Start button

[0597] 1054 Printed Circuit Board (PCB)

[0598] 1055 RCT battery

[0599] 1056 Battery

[0600] 1057 Adhesive

[0601] 1058 Lightbox Placeholder

[0602] 1060 Light Guide Placeholder

[0603] 1062 PCB placeholder

[0604] 1064 LED placeholder with LED

[0605] 1066 Content Management System (CMS)

[0606] 1068 USB gasket

[0607] 1070 proximal basic structure

[0608] 1076 Motor

[0609] 1077 Motor flange

[0610] 1078 Motor Gear

[0611] 1079 Screw

[0612] 1080 Box Detection Pins

[0613] 1081 Box detection pin opening for box abutment surface

[0614] 1082 Box Detection Spring

[0615] 1084 Box Detection Holder

[0616] 1086 Cartridge locking tab in syringe housing

[0617] 1088 NFC antenna for detecting RFID chip on the box

[0618] 1090 Distal end member connected to housing

[0619] 1092 bearings

[0620] 1094 Intermediate infrastructure components

[0621] 1095 distal base structural components

[0622] L Longitudinal orientation of the cartridge and autoinjector

[0623] Pns12L first and second pin safety cover locked position

[0624] Pns1IN unlocks the initial position

[0625] PnsL Locked position to prevent seal from being pierced by a needle

[0626] PnsC needle assembly connection location

[0627] PnsR Ready to Use Location

[0628] PnsD drug delivery location

[0629] PnsFL final locking position

[0630] Initial position of the PraIN release arm

[0631] Release position of the PraR release arm

[0632] R1 First rotation position of the indexing ring

[0633] R2 Second rotation position of the indexing ring

[0634] R3 Third rotation position of the indexing ring

Claims

1. A cartridge (100, 100b, 100c, 100d) for use in an autoinjector for administering a medicament, wherein the cartridge extends in a longitudinal direction (L) from a proximal end (102) to a distal end (104), and comprises: a syringe holder (300, 300d) configured to receive a syringe (200, 200d) containing the medicament, the syringe comprising a seal (208) at a proximal end (202) of the syringe (200, 200d), the seal (208) being configured to be pierced by a needle (222, 222b) to obtain fluid communication between the needle (222, 222b) and the medicament in the syringe (200, 200d); wherein the syringe holder (300, 300d) includes a needle assembly securing member (306) at a proximal end (302) of the syringe holder (300, 300d), wherein the needle assembly securing member (306) is configured to secure a needle assembly (220, 220b) including the needle (222, 222b) to the syringe holder (300, 300d) after the cartridge (100, 100b, 100c, 100d) is installed in the autoinjector (1000); a needle mounting blocking system (400, 400b), wherein a proximal end portion (402, 402b) of the needle mounting blocking system (400, 400b) is configured to move between a plurality of longitudinal positions relative to the syringe holder (300, 300d), wherein the plurality of longitudinal positions comprises at least: o a locked position (PnsL) that prevents the seal (208) from being pierced by the needle (222, 222b); and o a needle assembly connection position (PnsC) that allows the seal (208) to be pierced by the needle (222, 222b); and wherein movement of the proximal end (402, 402b) of the needle mounting blocking system (400, 400b) is configured to be controlled by the autoinjector (1000) after the cartridge (100, 100b, 100c, 100d) is secured in the autoinjector (1000).

2. Cassette according to any of the preceding claims, wherein the needle assembly connection position (PnsC) is distal to the locking position (PnsL).

3. A cartridge according to any one of the preceding claims, wherein the needle assembly securing member (306) secures the needle assembly (220, 220b) to the proximal end (302) of the syringe holder (300, 300d) by a threaded connection, or a press fit connection, or a snap fit connection, or a bayonet connection, or a combination thereof.

4. A cartridge according to any one of the preceding claims, wherein the needle assembly (220, 220b) is pre-mounted at the proximal end of the needle mounting blocking system (400, 400b) prior to use, and wherein a fluid connection between the syringe (200, 200d) and the needle (222, 222b) is obtained by distal movement of the needle assembly (220, 220b) and the needle mounting blocking system (400, 400b) relative to the syringe (200, 200d), the distal movement possibly being combined with a rotational movement of the needle assembly (220, 220b) relative to the syringe (200, 200d).

5. The cassette according to any of the preceding claims, wherein the cassette (100, 100b, 100c, 100d) further comprises an indexing ring (500, 500d) rotatable relative to the needle mounting blocking system (400, 400b) between a plurality of rotational positions, the plurality of rotational positions comprising at least: a first rotational position (R1) in which distal movement of the needle mounting blocking system (400, 400b) is prevented; and a second rotational position (R2) in which the needle mounting blocking system (400, 400b) is movable between the locking position (PnsL) and the needle assembly connection position (PnsC); Wherein when the cartridge (100, 100b, 100c, 100d) is secured in the autoinjector (1000), rotation of the indexing ring (500, 500d) is controlled by movement of one or more release members (1006) in the autoinjector (1000).

6. The cassette of claim 5, wherein the indexing ring (500, 500d) includes a track (514) extending from a first corner (516) to a second corner (518) of a surface area of ​​the indexing ring (500, 500d).

7. A box according to claim 6, wherein the track (514) extends from the first corner (516) toward the second corner (518) in an angled direction, wherein the angled direction is between 20 degrees and 70 degrees relative to the longitudinal direction of the box, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees.

8. The cartridge of claim 7, wherein the track (514) comprises a first track section (520) and a second track section (522), wherein: o The first track segment (520) extends in a first angular direction from the first corner (516) toward a first midpoint (526); o the second track segment (522) extends in a second angular direction along the longitudinal direction of the box from the first midpoint (526) to a second midpoint (528); wherein the first angled direction is between 20 and 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees, relative to the longitudinal direction of the cartridge, and Wherein the second angled direction is between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box.

9. A box according to claim 8, wherein the track (514) further includes a third track segment (524), wherein the third track segment (524) extends from the second midpoint (528) toward the second corner (518) in a third angled direction, wherein the third angled direction is between 20 degrees and 70 degrees relative to the longitudinal direction of the box, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees.

10. The cartridge of any one of the preceding claims, wherein the plurality of longitudinal positions between which the proximal end portion (402, 402b) of the needle mounting blocking system (400) is movable further comprises: a drug delivery site (PnsD) where the needle (222, 222b) is exposed; A final locking position (PnsFL) in which further longitudinal movement of the needle mounting blocking system (400, 400b) is prevented, wherein the final locking position (PnsFL) is proximal to the medicament delivery position (PnsD).

11. A box according to claim 10, wherein after the delivery of the drug, the distal movement of the one or more release members (1006) causes the indexing ring (500, 500d) to rotate back to the first rotational position (R1), whereby the proximal end (402, 402b) of the needle mounting blocking system (400, 400b) is longitudinally locked in the final locking position (PnsFL).

12. The cartridge according to any one of claims 10-11, wherein the plurality of longitudinal positions between which the proximal end portion (402, 402b) of the needle mounting blocking system (400, 400b) is movable further comprises: a ready-to-use position (PnsR) in which the proximal end (402, 402b) of the needle mounting blocking system (400, 400b) covers the needle (222, 222b), The needle mounting blocking system (400, 400b) is in the ready-to-use position (PnsR) before being moved to the drug delivery position (PnsD).

13. The cartridge according to any one of the preceding claims, wherein the proximal end (402, 402b) of the needle mounting blocking system (400, 400b) is further configured as a needle safety cap covering the needle after medicament delivery.

14. The cartridge according to any one of the preceding claims, wherein the needle mounting blocking system (400, 400d) comprises: ●First needle safety cover (410, 410d); ● a second needle safety cover (440, 440d), wherein the first needle safety cover (410, 410d) is displaceable in the longitudinal direction relative to the second needle safety cover (440, 440d); and One or more release arms (480, 580), wherein the one or more release arms (480, 580) are movable between at least two positions relative to the syringe holder (300, 300d), the at least two positions comprising: o an initial position (PraIN) in which the first needle safety cover (410, 410d) and the second needle safety cover (440, 440d) are separated by at most a first separation distance; and o A release position (PraR), in which the first needle safety cover (410, 410d) and the second needle safety cover (440, 440d) are allowed to move relative to each other to a second separation distance greater than the first separation distance.

15. The cassette of claim 14, wherein in the initial position (PraIN) the first needle safety cover (410, 410d) is prevented from proximal movement relative to the second needle safety cover (440, 440d).

16. The cassette according to any one of claims 14-15, wherein in the release position (PraR), the first needle safety cover (410, 410d) is allowed to move proximally relative to the second needle safety cover (440, 440d).

17. A box according to any one of claims 14 to 16, wherein the first needle safety cover (410, 410d) includes one or more cover locking tabs (431), which lock the first needle safety cover (410, 410d) in the final locking position (PnsFL) by preventing the first needle safety cover (410, 410d) from moving distally relative to the box housing (600, 600d).

18. The cartridge according to any one of claims 14-17, wherein the proximal end (402, 402d) of the needle mounting blocking system (400) is included in the second needle safety cover (440, 440d).

19. A box according to claims 14-18, wherein the second needle safety cover (440, 440d) is longitudinally locked relative to the syringe holder (300, 300d) when the proximal end (402) of the needle mounting blocking system (400) is in the locked position (PnsL) that prevents the seal (208) from being pierced by the needle (222).

20. A box according to any one of claims 14 to 19, wherein after the box (100, 100d) is secured in the automatic injector (1000), the second needle safety cover (440, 440d) is configured for longitudinal unlocking, whereby the second needle safety cover (440, 440d) can be moved in the distal direction relative to the syringe holder (300, 300d) to move the proximal end (402) of the needle mounting blocking system (400) to the needle assembly connection position (PnsC), thereby allowing the needle assembly (220) to be secured to the syringe holder (300, 300d).

21. The cassette of any one of claims 14-20, wherein the needle mounting blocking system (400) further comprises one or more cover springs (470) biased between the first needle safety cover (410, 410d) and the second needle safety cover (440, 440d).

22. The cartridge of claim 21 , wherein after securing the cartridge (100, 100d) in the autoinjector (1000), the first needle safety cover (410, 410d) and the one or more cover springs (470) are configured for longitudinal unlocking, whereby the first needle safety cover (410, 410d) and the one or more cover springs (470) are capable of moving in the distal direction relative to the syringe holder (300, 300d).

23. A box according to any one of claims 5 to 22, wherein the box (100d) further comprises one or more indexing ring release tabs (330), which are capable of moving relative to the indexing ring (500d), wherein when the box (100d) is fixed in the automatic injector (1000), movement of the one or more release members (1006) of the automatic injector to the first release member position inside the box (100d) causes the one or more indexing ring release tabs (330) to move from the initial position (PraIN) to the release position (PraR).

24. The cartridge of claim 23, wherein the one or more indexing ring release tabs (330) are part of the syringe holder (300d).

25. The cartridge of any one of claims 23-24, wherein the one or more indexing ring release tabs (330) comprise a protruding surface (332) that engages a blocking surface (540) on the indexing ring (500d) in the initial position (PraIN) to prevent the indexing ring (500d) from rotating from the first rotational position (R1) to the second rotational position (R2); wherein the one or more indexing ring release tabs (330) are configured to be deflected radially inwardly by proximal movement of the one or more release members (1006) when the cartridge (100d) is secured in the autoinjector (1000); wherein when the one or more indexing ring release tabs (330) are deflected radially inwardly, the protruding surface (332) no longer engages the blocking surface (540) on the indexing ring (500d), thereby enabling the indexing ring (500d) to rotate from the first rotational position (R1) to the second rotational position (R2).

26. A box according to claim 25, which is dependent on any one of claims 14-24, wherein the indexing ring (500d) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) by distal movement of the first needle safety cover (410d) when the protruding surface (332) no longer engages the blocking surface (540) on the indexing ring (500d).

27. A box according to claim 25 or 26, wherein the indexing ring (500d) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) by moving the second indexing ring engaging finger (469) on the second needle safety cover (440d) within the first sub-track section (550) on the indexing ring (500d).

28. A box according to any one of claims 23-27, wherein when the one or more release members (1006) are in the first release member position within the box (100d), the one or more release members (1006) engage the first track (514) in the dividing ring (500d) to prevent further rotation of the dividing ring (500d) from the second rotational position (R2) to the third rotational position (R3).

29. A box according to claim 26, wherein the indexing ring (500d) is capable of rotating from the second rotational position (R2) to the third rotational position (R3) when one or more release members (1006) of the automatic injector move proximally from the first release member position within the box (100d) to the second release member position within the box (100d).

30. A cartridge according to any one of claims 26 to 29 as dependent upon any one of claims 14 to 25, wherein the indexing ring (500d) is configured to rotate from the second rotational position (R2) to the third rotational position (R3) by distal movement of the first needle safety cover (410d) after the one or more release members (1006) of the automatic injector move proximally from the first release member position within the cartridge (100d) to the second release member position within the cartridge (100d).

31. A box according to any one of claims 26-30 dependent on any one of claims 14-25, wherein the indexing ring (500d) is configured to rotate from the second rotational position (R2) to the third second rotational position (R3) by moving the second indexing ring engaging finger (469) on the second needle safety cover (440d) within a third sub-track section (554) on the indexing ring (500d).

32. A box according to any one of claims 26-31, wherein when the indexing ring (500d) is in the third second rotational position (R3), the second indexing ring engaging finger (469) no longer abuts at least one of the one or more release arms (580) on the indexing ring (500d), thereby allowing the first needle safety cover (410d) and the second needle safety cover (440d) to move proximally relative to the indexing ring (500d) to a final locked position.

33. The cartridge of any one of claims 14-32, wherein the release arm (580) is part of the indexing ring (500d).

34. The cartridge of claim 33, wherein the release arm (580) is positioned at the proximal end (502) of the indexing ring (500d).

35. The cassette of any one of claims 14-34, wherein the first needle safety cover (410d) includes a first indexing ring engaging finger (433) and the second needle safety cover (440d) includes a second indexing ring engaging finger (469); wherein when the indexing ring (500d) is in the first rotational position (R1), the first indexing ring engagement finger (433) and the second indexing ring engagement finger (469) abut at least one of the one or more release arms (580) on the indexing ring (500d), thereby preventing proximal movement of the first needle safety cover (410d) and the second needle safety cover (440d) relative to the indexing ring (500d); and Wherein, when the indexing ring (500d) is in the second rotational position (R2), the first indexing ring engaging finger (433) no longer abuts at least one of the one or more release arms (580) on the indexing ring (500d), whereby the one or more cover springs (470) are configured to move the first needle safety cover (410d) proximally relative to the second needle safety cover (440d), thereby moving the first needle safety cover (410d) to a locked cover position, in which further relative longitudinal movement between the first needle safety cover (410d) and the second needle safety cover (440d) is prevented.

36. A box according to claim 35, wherein the first needle safety cover (410d) and the second needle safety cover (440d) include a first locking pair and a second locking pair, and in the locked cover position, the first locking pair prevents the first needle safety cover (410d) from moving proximally relative to the second needle safety cover (440d), and the second locking pair prevents the first needle safety cover (410d) from moving distally relative to the second needle safety cover (440d).

37. A box according to any one of claims 14-36, wherein the indexing ring (500d) includes a second track (544) extending from a first secondary corner (546) to a second secondary corner (548) of a surface area of ​​the indexing ring (500d), wherein the indexing ring (500d) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) by distal movement of the second needle safety cover (440d), whereby the second indexing ring engaging finger (469) on the second needle safety cover (440d) travels within the second track (544), thereby rotating the indexing ring (500d).

38. The cartridge of claim 37, wherein the second track (544) comprises a first secondary track segment (550) and a second secondary track segment (552), wherein: o The first secondary track segment (550) extends in a first secondary angular direction from the first secondary corner (546) toward a first secondary midpoint (526); o The second secondary track segment (552) extends from the first secondary midpoint (556) to a second secondary midpoint (558) in a second secondary angular direction along the longitudinal direction of the box; wherein the first pair of angled directions is between 20 and 70 degrees, such as between 30 and 60 degrees, such as between 35 and 55 degrees, such as between 40 and 50 degrees, such as approximately 45 degrees, relative to the longitudinal direction of the cartridge, and Wherein the second pair of angled directions is between -20 degrees and 20 degrees, such as between -10 degrees and 10 degrees, such as approximately 0 degrees, relative to the longitudinal direction of the box.

39. A box according to claim 38, wherein the second track (544) further includes a third sub-track segment (554), wherein the third sub-track segment (554) extends from the second sub-midpoint (558) toward the second sub-corner (548) in a third sub-angled direction, wherein the third sub-angled direction is between 20 degrees and 70 degrees relative to the longitudinal direction of the box, such as between 30 degrees and 60 degrees, such as between 35 degrees and 55 degrees, such as between 40 degrees and 50 degrees, such as approximately 45 degrees.

40. A cartridge according to any one of claims 1-6, wherein the indexing ring (500), wherein the indexing ring (500) is configured to rotate from the first rotational position (R1) to the second rotational position (R2) when the cartridge (100) is inserted into the auto-injector (1000) and the one or more release members (1006) included in the auto-injector (1000) move proximally within the track (514).

41. The cartridge of any one of claims 14-21 and 40, wherein the first needle safety cover (410) and the second needle safety cover (440) are permitted to move toward each other by compression of the one or more cover springs (470) prior to securing the cartridge (100) in the autoinjector (1000).

42. A box according to any one of claims 14-21 and 40-41, wherein the second needle safety cover (440) includes at least one flexible arm (446), the first needle safety cover (410) includes a first locking tab (416), and the one or more release arms (480) each include a protruding surface release component (486), wherein the protruding surface release component (486) limits the proximal movement of the first needle safety cover (410) relative to the second needle safety cover (440) in the initial position (PraIN) by preventing the at least one flexible arm (446) from flexing when adjacent to the first locking tab (416).

43. A box according to any one of claims 14-21 and 40-42, wherein when the needle assembly (220) is secured to the syringe holder (300), the second needle safety cover (440), the first needle safety cover (410) and the one or more release arms (480) are configured to move distally relative to the syringe holder (300).

44. A box according to claim 43, wherein when the needle assembly (220) is secured to the syringe holder (300), each of the second needle safety cover (440), the first needle safety cover (410) and the one or more release arms (480) moves distally a different distance relative to the syringe holder (300).

45. A box according to any one of claims 14-21 and 40-44, wherein the needle assembly (220) further includes a removable needle cap (228) that covers and protects the needle (222) prior to use, wherein after the needle assembly (220) is secured to the syringe holder (300) and the needle cap (228) is removed, the one or more cover springs (470) are suitable for pushing the first needle safety cover (410) in the proximal direction relative to the second needle safety cover (440), whereby the first needle safety cover (410) covers the needle (222) and the proximal end (402) of the needle mounting blocking system (400) is in a ready-to-use position (PnsR).

46. ​​A cassette according to any one of claims 14-21 and 40-45, wherein the one or more release arms (480) are locked relative to the syringe holder (300) after the needle assembly (220) is secured to the syringe holder (300).

47. A box according to claim 46, wherein when the one or more release arms (480) are in the release position (PraR) after the needle assembly (220) is secured to the syringe holder (300) and the needle cap (228) is removed, the second needle safety cover (440) is suitable for being moved proximally by the automatic injector (1000) while the one or more release arms (480) are locked relative to the syringe holder (300).

48. A box according to any one of claims 46-47, wherein when the one or more release arms (480) are in the release position (PraR) after the needle assembly (220) is fixed to the syringe holder (300) and the needle cap (228) is removed, the one or more cover springs (470) are suitable for pushing the first needle safety cover (410) in the proximal direction relative to the second needle safety cover (440), thereby causing the at least one flexible arm (446) to move proximally and enter into a position where the at least one flexible arm (446) is deflected through the protruding surface release component (486), thereby allowing the first locking tab (416) of the first needle safety cover (410) to pass through the at least one flexible arm (446), thereby using the one or more cover springs (470) to push the first needle safety cover (410) to the extended position relative to the second needle safety cover (440).

49. A box according to any one of claims 14-21 and 40-48, wherein when the box is in the ready to use position (PnsR), the one or more locking arms (440) are in the release position (PraR) and the needle mounting blocking system (400) is in a locked cover position, in which the first needle safety cover (410) is prevented from further relative longitudinal movement relative to the second needle safety cover (440).

50. A box according to claim 49, wherein the first needle safety cover (410) includes a second locking tab (420) positioned distal to the first locking tab (416), and the second needle safety cover (440) includes a stop surface (450) positioned proximal to the flexible arm (446), wherein in the locked cover position, the second locking tab (420) abuts the flexible arm (446) to prevent distal movement of the first needle safety cover (410) relative to the second needle safety cover (440), and the first locking tab (416) abuts the stop surface (450) to prevent proximal movement of the first needle safety cover (410) relative to the second needle safety cover (440).

51. A box according to claim 50, wherein the needle assembly (220) includes a removable needle cap (228), and wherein when the proximal end (402) of the needle mounting blocking system (400) is in the drug delivery position (PnsD), removal of the needle cap (228) will allow the proximal end (402) of the needle mounting blocking system (400) to move proximally.

52. The cartridge of any one of claims 1-8, wherein the plurality of longitudinal positions between which the proximal end portion (402b) of the needle mounting blocking system (400b) is movable further comprises: A drug delivery site (PnsD) where the needle (222) is exposed; a final locking position (PnsFL) in which further longitudinal movement of the needle mounting blocking system (400b) is prevented, The drug delivery position (PnsD) and the final locking position (PnsFL) are at the same longitudinal position.

53. A box according to claim 52, wherein after delivery of the medicament, distal movement of the one or more release members (1006) in the automatic injector (1000) is configured to rotate the indexing ring (500) back to the first rotational position (R1), whereby the proximal end (402b) of the needle mounting blocking system (400b) is longitudinally locked in the final locking position (PnsFL).

54. A system for use in an automatic injector for administering a medicament, the system comprising: ● A box according to any one of claims 1 to 53; a syringe (200, 200d) containing the medicament and a seal (208) at a proximal end (202) of the syringe (200, 200d), the seal (208) being configured to be pierced by a distal end of a needle (222) to obtain fluid communication between the medicament in the syringe (200, 200d) and the needle (222, 222b); and a needle assembly (220, 220b) comprising the needle (222, 222b), a needle assembly adapter (226, 226b) for securing the needle assembly (220, 220b) to the syringe holder (300, 300d), and a removable needle cap (228) covering and protecting the needle (222); wherein the needle installation blocking system (400, 400b) prevents the distal end of the needle (222, 222b) from piercing the seal (208) before the cartridge (100, 100d) is secured in the autoinjector (1000).

55. The system of claim 54, wherein the needle assembly (220b) further comprises a needle assembly shield (235b), the needle assembly shield being configured to be in a plurality of positions, the plurality of positions comprising: An initial delivery position, in which the needle assembly shield (235b) of the needle assembly (220b) covers the needle (222b); A drug delivery site, where the needle (222b) is exposed; • A final locked position, in which the needle assembly shield (235b) of the needle assembly (220b) covers the needle (222b).

56. The system according to any one of claims 54-55, further comprising the autoinjector (1000), wherein the autoinjector (1000) is configured to receive the cartridge (100, 100d).

57. The system of claim 56, wherein the autoinjector (1000) comprises one or more release members (1006) configured to move into the cartridge (100, 100d) when the cartridge has been received in the autoinjector (1000).

58. An autoinjector (1000) for administering a medicament, the autoinjector (1000) being configured to receive any one of the cartridges (100, 100d) according to claims 1-53 and / or any one of the systems according to claims 54-55 without requiring modification of the autoinjector (1000).

59. A system comprising an autoinjector (1000) for administering a medicament, the autoinjector (1000) being configured to receive any of the cartridges (100, 100d) according to claims 1-53 without modification.

60. The system of claim 59, further comprising a needle assembly (220, 220b) comprising the needle (222, 222b), a needle assembly adapter (226) for securing the needle assembly (222, 222b) to the syringe holder (300, 300d), and a removable needle cap (228) covering and protecting the needle (220, 220b), wherein the needle installation blocking system (400, 400b) prevents the distal end of the needle (222, 222b) from piercing the seal (208) prior to securing the cartridge (100, 100d) in the autoinjector (1000).

61. The system of claim 60, wherein the needle assembly (220) further comprises a needle assembly shield (235b), the needle assembly shield being configured to be in a plurality of positions, the plurality of positions comprising: An initial delivery position, in which the needle assembly shield (235b) of the needle assembly (220b) covers the needle (222b); A drug delivery site, where the needle (222b) is exposed; • A final locked position, in which the needle assembly shield (235b) of the needle assembly (220b) covers the needle (222b).

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