Traumatic injury pain relieving liquid and preparation method thereof

Abstract

The invention provides a traumatic injury pain relieving liquid and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. Comprising the following components: a Yi nationality medicine fresh medicine group: Yi nationality medicine fresh medicine group: Yi nationality medicine fresh medicine group: Yi nationality medicine fresh medicine group (fresh freeze-dried powder), radix angelicae sinensis (fresh freeze-dried powder), adhatoda ventricosa, adhatoda ventricosa The blood-activating and pain-relieving group comprises pseudo-ginseng, safflower, frankincense, myrrh and ground beeltle; the transdermal penetration enhancing group comprises borneol, camphor, menthol and radix angelicae; and the auxiliary material solvent group comprises yellow wine-based ethanol, azone, glycerol, cymbopogon distans oil and the balance of distilled water. The traumatic injury pain-relieving liquid is reasonable in component and synergistic in component, has the remarkable effects of promoting blood circulation to arrest pain, diminishing swelling and dissipating blood stasis, promoting reunion of fractured tendons and bones and the like, is good in transdermal absorption effect and high in bioavailability, and can quickly relieve uncomfortable symptoms caused by traumatic injuries.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traumatic analgesic liquid and a preparation method thereof. Background Art

[0002] Traumatic injuries refer to injuries (such as muscles, ligaments, joints, etc.) caused by external impact, falls or twists. The injured area often has pain, swelling, bleeding, and in severe cases, fractures, dislocations, etc. At present, the efficacy of drugs for treating such diseases at home and abroad is not significant, and there are problems such as high toxicity and irritation, and inconvenience in use. Western medicine often uses Voltaren emulsion, but there are many adverse reactions, mainly skin itching, redness, and stinging. In traditional Chinese medicine, bruises are classified as tendon injuries, so acupuncture and physical therapy, black ointment, white ointment, etc. are often used. However, they have shortcomings such as slow effect, long treatment course, and poor long-term efficacy.

[0003] Yi medicine, a vital component of traditional Chinese medicine, boasts extensive experience in treating injuries from falls, boasting numerous distinctive medicinal herbs and unique treatment methods. Combining the unique characteristics of Yi medicine with modern formulation techniques is crucial for developing a fast-acting, low-cost, convenient, and safe pain relief medication for injuries from falls. Summary of the Invention

[0004] The present invention aims to provide a Yi medicine-based analgesic solution and its preparation method, to address the problems of poor efficacy and significant side effects of existing traumatic injury treatment drugs. The solution has rational components, each of which works synergistically, and has significant effects such as promoting blood circulation and relieving pain, reducing swelling and dispersing blood stasis, and repairing tendons and bones. It also has good transdermal absorption and high bioavailability, and can quickly relieve the discomfort symptoms caused by traumatic injuries.

[0005] To this end, the technical solution of the present invention is a traumatic analgesic liquid, which comprises the following components in parts by weight: 22-28 parts of Yi medicine fresh medicine group: 8-10 parts of Jianzhongqing (fresh freeze-dried powder), 5-7 parts of blood angelica (fresh freeze-dried powder), 4-6 parts of large bone, 3-5 parts of small bone, 2-4 parts of small Baitong; 20-30 parts of blood circulation and analgesic group: 10-14 parts of Panax notoginseng, 4-6 parts of safflower, 2-4 parts of frankincense, and 2-3 parts of myrrh. The composition includes: 2-4 parts of medicine, 1-3 parts of Eupolyphaga sinensis; 8-19 parts of transdermal penetration enhancing group: 3-5 parts of borneol, 2-4 parts of camphor, 1-3 parts of menthol, 2-4 parts of Angelica dahurica; 35-45 parts of auxiliary material solvent group: 28-32 parts of rice wine-based ethanol (of which rice wine accounts for 14-16 parts and ethanol accounts for 14-16 parts), 0.5-1.5 parts of azone, 4-6 parts of glycerol, 3-5 parts of rue herb oil, and the balance is distilled water.

[0006] Furthermore, in the Yi medicine fresh medicine group, the Jianzhongqing (fresh freeze-dried powder) is 8 parts, the blood angelica (fresh freeze-dried powder) is 6 parts, the large bone is 5 parts, the small bone is 4 parts, and the small Baitong is 3 parts.

[0007] Furthermore, in the blood-activating and analgesic group, the Panax notoginseng is 12 parts, the safflower is 5 parts, the frankincense is 3 parts, the myrrh is 3 parts, and the earthworm is 2 parts.

[0008] Furthermore, in the transdermal penetration enhancement group, the borneol is 4 parts, the camphor is 3 parts, the menthol is 2 parts, and the angelica dahurica is 3 parts.

[0009] Furthermore, in the auxiliary material solvent group, the rice wine-based ethanol is 30 parts, wherein the weight ratio of rice wine to ethanol is 1:1.

[0010] Furthermore, in the auxiliary material solvent group, the azone is 1.2 parts, the glycerol is 5 parts, and the rue herb oil is 5 parts.

[0011] Furthermore, the Jianzhongqing (fresh freeze-dried powder) and Xue Danggui (fresh freeze-dried powder) are both prepared by the following method: fresh medicinal materials are taken, washed and freeze-dried (temperature -40°C to -30°C, vacuum degree 10-30Pa), crushed and then passed through an 80-mesh sieve.

[0012] A method for preparing a traumatic analgesic solution, using the components described above in parts by weight, comprises the following steps:

[0013] S1. Weigh each component in parts by weight, and mix the Yi medicine group (except fresh freeze-dried powder), the analgesic group and Angelica dahurica, respectively, through an 80-120 mesh sieve and set aside;

[0014] S2. Add rice wine-based ethanol to the mixed raw materials in step S1, stir evenly and seal and soak for 7-10 days (temperature 20-25 ° C), stirring 3-5 times a day for 5-10 minutes each time;

[0015] S3. After soaking, filter through gauze and then filter through filter paper to obtain an extract;

[0016] S4. Borneol, camphor, menthol, azone, glycerin, rue vanilla oil were added to the extract of step S3 and stirred at 30-40 ℃ until completely dissolved;

[0017] S5. Add distilled water to make up the balance, stir evenly, filter through a 0.45μm microporous filter membrane, and package.

[0018] Furthermore, in step S1, the crushed product is sieved through a 100-mesh sieve.

[0019] Furthermore, in step S2, the soaking temperature is 22°C, the soaking time is 8 days, and the mixture is stirred 3 times a day, each time for 8 minutes; in step S4, the stirring temperature is 35°C, and the stirring speed is 150 r / min.

[0020] The beneficial effect of the present invention is that it combines Yi medicine fresh medicine with traditional Chinese medicine for promoting blood circulation and relieving pain, and simultaneously adds transdermal penetration-promoting ingredients and suitable auxiliary materials and solvents to form a scientific and reasonable system. Jianzhongqing, Xue Danggui, Da Bogu, Xiao Bogu, and Xiao Baitong in the Yi medicine fresh medicine group are commonly used medicinal materials for Yi medicine to treat traumatic injuries and have unique therapeutic effects; Panax notoginseng, safflower, frankincense, myrrh, and Eupolyphagia sinensis in the blood circulation and relieving pain group are medicinal materials in traditional Chinese medicine with good blood circulation and analgesic, swelling-removing and blood stasis-dispersing effects, and synergistically act with the Yi medicine fresh medicine group to enhance the therapeutic effect; borneol, camphor, menthol, and Angelica dahurica in the transdermal penetration-promoting group can promote transdermal absorption of drugs and improve bioavailability; the rice wine-based ethanol in the auxiliary material and solvent group is not only a good solvent but also has certain pharmacological effects, azone further enhances the transdermal effect, glycerol plays a role in moisturizing and reducing irritation, and distilled water is used to adjust the concentration to make the components more stable. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The present invention is a process flow chart for the preparation of the traumatic analgesic liquid. DETAILED DESCRIPTION

[0022] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0023] The present invention provides a traumatic analgesic liquid based on the characteristics of Yi medicine, which comprises the following components in parts by weight: 22-28 parts of a Yi medicine fresh medicine group: 8-10 parts of Jianzhongqing (fresh freeze-dried powder), 5-7 parts of Xuedangui (fresh freeze-dried powder), 4-6 parts of Dabugu, 3-5 parts of Xiaobugu, and 2-4 parts of Xiaobaitong;

[0024] Blood circulation and analgesia group 20-30 parts: Panax notoginseng 10-14 parts, safflower 4-6 parts, frankincense 2-4 parts, myrrh 2-4 parts, and Eupolyphaga sinensis 1-3 parts;

[0025] Transdermal penetration enhancement group 8-19 parts: borneol 3-5 parts, camphor 2-4 parts, menthol 1-3 parts, angelica 2-4 parts;

[0026] The excipient solvent group comprises 35-45 parts: 28-32 parts rice wine-based ethanol (of which rice wine accounts for 14-16 parts and ethanol accounts for 14-16 parts), 0.5-1.5 parts azone, 4-6 parts glycerin, 3-5 parts rue herb oil, and the balance is distilled water. Rue herb oil is obtained from fresh rue herb leaves and stems through steam distillation to obtain 0.7-1% volatile oil. Rue herb is a traditional Chinese medicinal herb and aromatic plant with heat-clearing and detoxifying, wind-dispelling and analgesic, and antibacterial and anti-inflammatory properties. Modern research confirms that it contains active ingredients such as volatile oils and flavonoids, possessing both medicinal and anthelmintic properties.

[0027] like Figure 1 As shown, a method for preparing the above-mentioned Yi medicine-based analgesic solution for traumatic injuries comprises the following steps:

[0028] S1. Raw material pretreatment: Weigh each component by weight, crush the Yi medicine fresh medicine group (except freeze-dried powder), blood circulation and analgesia group and Angelica dahurica separately, pass through an 80-120 mesh sieve, mix well and set aside; 100 mesh is preferred, under which the dissolution rate of the active ingredient reaches more than 85%, and the filtration difficulty caused by too fine powder is avoided; Jianzhongqing (fresh freeze-dried powder) and Xue Danggui (fresh freeze-dried powder) are both prepared by the following method: take fresh medicinal materials, wash and freeze-dry (temperature -40℃ to -30℃, vacuum degree 10-30Pa), crush and pass through an 80 mesh sieve.

[0029] S2. Soaking extraction: Add rice wine-based ethanol to the mixed raw materials, stir evenly, and then seal and soak for 7-10 days (20-25°C), stirring 3-5 times a day, each time for 5-10 minutes.

[0030] S3. Preliminary filtration and purification: After soaking, filter through gauze to remove crude fibers, then filter through filter paper to obtain the extract.

[0031] S4. Dissolving ingredients: Add borneol, camphor, menthol, azone, glycerin, and rue oil to the extract and stir at 30-40°C until completely dissolved.

[0032] S5. Final filtration preparation: Add distilled water to make up the balance, stir evenly, filter through a 0.45μm microporous filter membrane, and package.

[0033] This preparation method ensures full contact between the raw materials and the solvent through reasonable control of the crushing particle size; appropriate soaking time and stirring operation are conducive to the full dissolution of the active ingredients; step-by-step filtration removes impurities to improve the purity of the drug solution; and controls the temperature and stirring conditions to fully dissolve the added ingredients, ensuring stable preparation quality.

[0034] The present invention utilizes a soaking method to treat raw materials, based on the solubility characteristics of the active ingredients in traditional Chinese medicine (TCM). Many active ingredients in TCM, such as alkaloids, volatile oils, and flavonoids, have a certain solubility in organic solvents such as ethanol or alcohol-water mixed solvents. Prolonged soaking allows the solvent to gradually penetrate the tissues of the medicinal material, allowing the active ingredients to fully dissolve and be released into the solvent. Studies have shown that soaking can effectively preserve the active ingredients in medicinal materials containing a high concentration of fat-soluble and volatile components, preventing the destruction of some components due to high-temperature decoction. Furthermore, the rice wine-based ethanol mixed solvent used in the present invention combines the strong permeability and solubility of ethanol with the multiple active ingredients found in rice wine, which interact with the active ingredients in the medicinal material and promote their dissolution. Furthermore, stirring during the soaking process increases the contact area between the medicinal material and the solvent, improving the dissolution efficiency of the active ingredients.

[0035] In the present invention, the method of slow-cooking is not adopted, mainly based on the following considerations. On the one hand, some of the medicinal materials in the component, such as Jianzhongqing (fresh freeze-dried powder) and Xuedangui (fresh freeze-dried powder), etc., are prepared by freeze-drying technology, and their active ingredients are retained at low temperatures. If high-temperature decoction is adopted, the structure and activity of these components may be destroyed. As for other medicinal materials in the blood-activating and analgesic group and the Yi medicine fresh medicine group, their active ingredients can be dissolved well under soaking conditions, and the expected extraction effect can be achieved without decoction. Therefore, considering the medicinal material characteristics and the stability of the active ingredients, the present invention selects the soaking method as the extraction method, instead of slow-cooking.

[0036] Example 1

[0037] 1. Components (parts by weight): 8 parts of Jianzhongqing (fresh freeze-dried powder), 6 parts of Blood Angelica (fresh freeze-dried powder), 5 parts of large bone, 4 parts of small bone, 3 parts of Xiaobaitong, 12 parts of Panax notoginseng, 5 parts of safflower, 3 parts of frankincense, 3 parts of myrrh, 2 parts of Eupolyphaga, 4 parts of borneol, 3 parts of camphor, 2 parts of menthol, 3 parts of Angelica dahurica, 30 parts of rice wine-based ethanol (15 parts of rice wine + 15 parts of ethanol), 1 part of azone, 5 parts of glycerol, 5 parts of rue herb oil, and the balance is distilled water;

[0038] 2. Preparation steps:

[0039] Grind through a 100-mesh sieve, seal and soak at 22°C for 8 days, stirring 3 times a day (8 minutes each time);

[0040] After initial filtration, the added ingredients were dissolved at 35°C (stirring speed 150 r / min);

[0041] After final filtration, divide into subpackages and you are done.

[0042] Example 2

[0043] 1. Ingredients: 10 parts of Jianzhongqing, 7 parts of Xuedangui, 6 parts of Dabogu, 5 parts of Xiaobogu, 4 parts of Xiaobaitong, 14 parts of Panax notoginseng, 6 parts of Safflower, 4 parts of Frankincense, 4 parts of Myrrh, 3 parts of Eupolyphaga, 5 parts of Borneolum, 4 parts of Camphor, 3 parts of Menthol, 4 parts of Angelica dahurica, 32 parts of Yellow Wine-based Ethanol (16 parts of Yellow Wine + 16 parts of Ethanol), 1.5 parts of Azone, 6 parts of Glycerin, 4 parts of Rutaecarpa Oil, and the balance is distilled water;

[0044] 2. Preparation steps: crush through 80 mesh sieve, soak at 20°C for 10 days, stir 5 times a day (5 minutes each time), dissolve at 30°C (stirring speed 100 r / min), and the rest is the same as Example 1.

[0045] Example 3

[0046] 1. Ingredients: 9 parts of Jianzhongqing, 5 parts of Xuedangui, 4 parts of Dabogu, 3 parts of Xiaobogu, 2 parts of Xiaobaitong, 10 parts of Panax notoginseng, 4 parts of Safflower, 2 parts of Frankincense, 2 parts of Myrrh, 1 part of Eupolyphaga, 3 parts of Borneolum, 2 parts of Camphor, 1 part of Menthol, 2 parts of Angelica dahurica, 28 parts of Yellow Wine-based Ethanol (14 parts of Yellow Wine + 14 parts of Ethanol), 0.5 parts of Azone, 4 parts of Glycerin, 5 parts of Rutaecarpa Oil, and the balance is distilled water;

[0047] 2. Preparation steps: crush through a 120-mesh sieve, soak at 25°C for 7 days, stir 4 times a day (10 minutes each time), dissolve at 40°C (stirring speed 200 r / min), and the rest is the same as Example 1.

[0048] The mechanism of action of the present invention is as follows: Yi medicine fresh medicine group: Jianzhongqing (fresh freeze-dried powder) has the effect of clearing away heat and detoxifying. As a holy medicine for Yi medicine trauma, it can effectively remove heat and toxins from the injured area; Xue Danggui (fresh freeze-dried powder) can replenish blood and promote blood circulation, and play a role in targeting the characteristics of Yi medicine trauma; Da Bogu can repair tendons and bones, and is the core medicine for Yi medicine bone injuries; Xiao Bogu works with Da Bogu to enhance the effect of dispersing blood stasis and reducing swelling; Xiao Baitong (Yi medicine) has the effect of dredging meridians and dispersing nodules, and is a secret medicine of Yi medicine.

[0049] Blood circulation and analgesia group: Panax notoginseng, as the main drug, has the effect of removing blood stasis and relieving pain, and can effectively relieve pain and blood stasis symptoms; Safflower promotes blood circulation and unblocks menstruation; Frankincense and Myrrh work synergistically to reduce swelling, promote tissue regeneration, and relieve pain; Eupolyphaga sinensis removes blood stasis and sets bones, which helps repair the injured area.

[0050] Transdermal penetration enhancement group: Borneol stimulates the skin and penetrates the skin, while also providing a cooling and analgesic effect; camphor warms and promotes penetration, also providing a local anesthetic effect; menthol cools and promotes penetration, relieving muscle spasms; and angelica dispels wind and dampness, enhancing transdermal efficacy. These ingredients work together to promote drug penetration through the skin and into the affected area.

[0051] Excipient solvent group: Yellow rice wine-based ethanol is used as a dual solvent. Yellow rice wine retains active substances such as amino acids and esters and has certain pharmacological effects. Ethanol, as a highly permeable carrier, can promote drug dissolution and transdermal penetration. Azone is a chemical penetration enhancer that can significantly improve the bioavailability of drugs. Glycerin moisturizes and prevents dryness and cracking, reducing drug irritation to the skin. Distilled water is used to adjust the concentration so that the components reach an appropriate usage concentration.

[0052] The invention has the synergistic effect of multiple components: the fresh medicine of Yi medicine is combined with traditional Chinese medicine, and each component plays its own advantages and works synergistically to achieve multiple functions such as clearing away heat and detoxifying, replenishing blood and activating blood circulation, repairing tendons and setting bones, dispersing blood stasis and reducing swelling, activating blood circulation and relieving pain, and has comprehensive therapeutic effects; the transdermal absorption effect is good: the combined effect of the transdermal penetration promoting group and the auxiliary material solvent group significantly improves the transdermal absorption efficiency of the drug, so that the drug can quickly reach the lesion site and take effect quickly; the therapeutic effect is significant: the various active ingredients in the components play a role in the pathological process of traumatic injury, can quickly relieve symptoms such as blood stasis, swelling, and pain, and promote the repair of the injured site; high safety: the use of natural medicinal materials and suitable auxiliary materials reduces irritation to the skin and has high safety; the preparation process is simple, and the preparation method of the invention is simple and easy to implement, and is suitable for industrial production.

[0053] However, the above description is merely a specific embodiment of the present invention and should not be used to limit the scope of implementation of the present invention. Therefore, the replacement of equivalent components, or equivalent changes and modifications made according to the scope of protection of the present invention should still fall within the scope of the claims of the present invention.

Claims

1. A traumatic analgesic solution, characterized in that: The invention comprises the following components in parts by weight: 22-28 parts of Yi medicine fresh medicine group: 8-10 parts of Jianzhongqing, 5-7 parts of Xuedangui, 4-6 parts of Dabogu, 3-5 parts of Xiaobogu, and 2-4 parts of Xiaobaitong; 20-30 parts of blood-activating and analgesic group: 10-14 parts of Panax notoginseng, 4-6 parts of safflower, 2-4 parts of frankincense, 2-4 parts of myrrh, and 1-3 parts of Eupolyphaga sinensis; 8-19 parts of transdermal penetration-promoting group: 3-5 parts of borneol, 2-4 parts of camphor, 1-3 parts of menthol, and 2-4 parts of Angelica dahurica; 35-45 parts of auxiliary material solvent group: 28-32 parts of rice wine-based ethanol, 0.5-1.5 parts of azone, 4-6 parts of glycerol, 3-5 parts of rue herb oil, and the balance is distilled water.

2. The analgesic liquid for traumatic injuries according to claim 1, characterized in that: In the Yi medicine fresh medicine group, the Jianzhongqing is 8 parts, the Xuedangui is 6 parts, the Dabogu is 5 parts, the Xiaobogu is 4 parts, and the Xiaobaitong is 3 parts.

3. The analgesic solution for traumatic injuries according to claim 1, characterized in that: In the blood-activating and analgesic group, the Panax notoginseng is 12 parts, the safflower is 5 parts, the frankincense is 3 parts, the myrrh is 3 parts, and the earthworm is 2 parts.

4. The analgesic liquid for traumatic injuries according to claim 1, characterized in that: In the transdermal penetration enhancement group, the borneol is 4 parts, the camphor is 3 parts, the menthol is 2 parts, and the angelica dahurica is 3 parts.

5. The analgesic liquid for traumatic injuries according to claim 1, characterized in that: In the auxiliary material solvent group, the rice wine-based ethanol is 30 parts, wherein the weight ratio of rice wine to ethanol is 1:

1.

6. The analgesic solution for traumatic injuries according to claim 1, characterized in that: In the auxiliary material solvent group, the amount of azone is 1.2 parts, the amount of glycerol is 5 parts, and the amount of rue herb oil is 5 parts.

7. The analgesic solution for traumatic injuries according to claim 1, characterized in that The Jianzhongqing and Xue Danggui herbal medicines are prepared by the following method: fresh medicinal materials are taken, washed, freeze-dried, crushed and then passed through an 80-mesh sieve.

8. A method for preparing a traumatic analgesic solution, characterized in that: Using the components according to any one of claims 1 to 7 in parts by weight, comprising the following steps: S1. Weigh each component in parts by weight, and the Yi medicine group except the freeze-dried powder, the analgesic group and Angelica dahurica were crushed, sieved through an 80-120 mesh, and mixed for standby; S2. Add rice wine-based ethanol to the mixed raw material in step S1, stir well and seal and soak for 7-10 days, stirring 3-5 times a day for 5-10 minutes each time; S3. After soaking, filter through gauze and then filter through filter paper to obtain an extract; S4. Borneol, camphor, menthol, azone, glycerin, rue vanilla oil were added to the extract of step S3 and stirred at 30-40 ℃ until completely dissolved; S5. Add distilled water to make up the balance, stir evenly, filter through a 0.45μm microporous filter membrane, and package.

9. The method for preparing a traumatic analgesic solution according to claim 8, characterized in that: In step S1, the crushed product is passed through a 100-mesh sieve.

10. The method for preparing a traumatic analgesic solution according to claim 8, characterized in that: In step S2, the soaking temperature is 22°C, the soaking time is 8 days, and the stirring is 3 times a day, each time for 8 minutes; in step S4, the stirring temperature is 35°C, and the stirring speed is 150 r / min.

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