Medical auditory meatus cleaning fluid for auditory meatus cleaning and preparation method of medical auditory meatus cleaning fluid

Abstract

The invention relates to a medical auditory meatus cleaning solution for auditory meatus cleaning and a preparation method thereof, and belongs to the technical field of production of medical supplies. Comprising a traditional Chinese medicine extract, a cutin softener and water for injection, the traditional Chinese medicine extracting solution is an extracting solution of fructus cnidii powder, cortex phellodendri powder, radix sophorae flavescentis powder, mint powder, herba artemisiae scopariae powder, fructus forsythiae powder, cortex dictamni powder, dandelion powder and borneol. The preparation method comprises the following steps: mixing the raw materials of the traditional Chinese medicine composition in parts by weight, adding water, decocting, filtering to obtain filtrate, concentrating the filtrate under reduced pressure to obtain the traditional Chinese medicine extracting solution, and uniformly mixing the traditional Chinese medicine extracting solution with the cutin softener and the water for injection to obtain the medical ear canal cleaning solution for cleaning the ear canal. The medical ear canal cleaning fluid for cleaning the ear canal has the following beneficial effects that the cleaning fluid can be used for removing dust, cerumen (earwax), insects and other foreign matters in the ear canal, and relieving itching, tinnitus and other uncomfortable symptoms.

Description

Technical Field

[0001] The invention relates to a medical ear canal cleaning liquid for cleaning the ear canal, belonging to the technical field of medical product production. Background Art

[0002] Fungal otitis externa is a common ear disease. It is a skin infection caused by fungi that invade the patient's external auditory canal. Excessive discharge from the external auditory canal can cause a blocked feeling in the ear and may even lead to otitis media or eardrum perforation, which can damage hearing.

[0003] Ear irrigation is a common medical procedure, widely used to remove cerumen blockages, inflammatory secretions, or foreign matter. Current technologies are incomplete and have the following drawbacks: 1. Traditional cleaning methods (such as cotton swabs and ear picks) tend to push earwax deeper into the ear canal and are difficult to remove foreign matter such as tiny dust particles or insects. 2. Existing products may have a narrow antibacterial spectrum, making them limitedly effective against fungal otitis externa, requiring hospitalization for treatment.

[0004] In order to solve one of the above problems, a medical ear canal cleaning solution for cleaning the ear canal is urgently needed. Summary of the Invention

[0005] In view of the above deficiencies in the prior art, the technical problem to be solved by the present invention is: how to control infections such as otitis externa, reduce inflammation and pain, avoid hospitalization and treatment of patients with fungal otitis externa, and reduce their economic burden. To this end, a medical ear canal cleaning solution for ear canal cleaning is provided.

[0006] The medical ear canal cleaning solution for ear canal cleaning of the present invention is characterized by comprising a traditional Chinese medicine extract, a keratin softener and water for injection; the traditional Chinese medicine extract is an extract of Cnidium monnieri, Phellodendron amurense, Sophora flavescens, Mentha, Artemisia capillaris, Forsythia suspensa, Dictamni cortex, Taraxacum mongolicum and borneol.

[0007] Preferably, the Chinese medicine extract is composed of the following raw materials in parts by mass: 10-20 parts of Cnidium monnieri, 12-15 parts of Phellodendron amurense, 10-12 parts of Sophora flavescens, 8-10 parts of Menthol, 8-10 parts of Artemisia capillaris, 5-8 parts of Forsythia suspensa, 4-5 parts of Dictamni bark, 8-10 parts of Taraxacum mongolicum, and 2-3 parts of Borneol; 1-2 parts of the keratin softener; The water for injection is 1100-1300 parts.

[0008] Preferably, the Chinese medicine extract is composed of the following raw materials in parts by mass: 15 parts of Cnidium monnieri, 12 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 8 parts of Menthol, 10 parts of Artemisia capillaris, 8 parts of Forsythia suspensa, 5 parts of Dictamni cortex, 10 parts of Taraxacum mongolicum and 3 parts of Borneol; 1 part of the keratin softener; and 1100 parts of water for injection.

[0009] Preferably, the keratin softening agent is a polyhydroxy acid (PHA).

[0010] The present invention also discloses a method for preparing a medical ear canal cleaning solution for cleaning the ear canal, characterized in that the preparation method comprises the following steps: mixing the raw materials of the above-mentioned traditional Chinese medicine composition in parts by weight, decocting with water, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to obtain the traditional Chinese medicine extract, and uniformly mixing the traditional Chinese medicine extract with a keratin softener and water for injection to obtain the medical ear canal cleaning solution for cleaning the ear canal.

[0011] Preferably, the preparation method comprises the following steps: weighing Cnidium monnieri parts, Phellodendron chinense parts, Sophora flavescens parts, Mentha parts, Artemisia capillaris parts, Forsythia suspensa parts, Dictamni cortex parts, Taraxacum mongolicum parts and borneol as needed; mixing the above raw material components and decocting them with water for 1 hour, wherein the amount of water added is 10 to 20 times the total weight of the raw materials; filtering the above traditional Chinese medicine liquid and concentrating the filtrate under reduced pressure, wherein the relative density of the filtrate after reduced pressure concentration is 0.9 to 1.1, and the pressure of reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract.

[0012] Preferably, when filtering the traditional Chinese medicine liquid and the filtration mesh size needs to be gradually increased, 120 mesh, 180 mesh and 200 mesh are used respectively.

[0013] Preferably, the filtrate is concentrated under reduced pressure to a relative density of 1.0.

[0014] Compared with the prior art, the present invention has the following beneficial effects: The medical ear canal cleaning liquid for cleaning the ear canal of the present invention can remove foreign matter such as dust, cerumen (earwax), insects, etc. in the ear canal, and relieve discomfort symptoms such as itching and tinnitus.

[0015] The medical ear canal cleaning solution for ear canal cleaning of the present invention can reduce bacterial growth and lower the risk of diseases such as otitis externa and otitis media through regular cleaning.

[0016] The medical ear canal cleaning solution for ear canal cleaning of the present invention has antibacterial components, can control infections such as otitis externa, relieve inflammation and pain, avoid hospitalization and treatment of patients with fungal otitis externa, and reduce their economic burden. DETAILED DESCRIPTION

[0017] The present invention will be further described below with reference to embodiments: The present invention will be further illustrated below by specific embodiments, but the present invention is not limited thereto. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

[0018] Example 1, a medical ear canal cleaning solution for ear canal cleaning, comprising a traditional Chinese medicine extract, a keratin softener and water for injection; the traditional Chinese medicine extract is composed of the following raw materials in parts by mass: 15 parts of Cnidium monnieri, 12 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 8 parts of Menthol, 10 parts of Artemisia capillaris, 8 parts of Forsythia suspensa, 5 parts of Dictamni cortex, 10 parts of Taraxacum mongolicum and 3 parts of Borneol; 1 part of the keratin softener; and 1100 parts of water for injection.

[0019] Furthermore, the keratin softener is polyhydroxy acid (PHA).

[0020] The preparation method comprises the following steps: weighing Cnidium monnieri, Phellodendron chinense, Sophora flavescens, Mentha, Artemisia capillaris, Forsythia suspensa, Dictamni cortex, Taraxacum officinale and Borneolum Syntheticum as needed; mixing the raw material components, adding water and boiling for 1 hour, wherein the amount of water added is 20 times the total weight of the raw materials; filtering the traditional Chinese medicine liquid, and concentrating the filtrate under reduced pressure, wherein the relative density of the filtrate after reduced pressure concentration is 1.0, and the pressure of reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract; and uniformly mixing the traditional Chinese medicine extract with a keratin softener and water for injection to obtain a medical ear canal cleaning solution for ear canal cleaning.

[0021] Furthermore, when filtering the Chinese medicine liquid, it is necessary to gradually increase the filtration mesh number, using 120 mesh, 180 mesh and 200 mesh respectively.

[0022] Example 2, a medical ear canal cleaning solution for ear canal cleaning, comprising a traditional Chinese medicine extract, a keratin softener and water for injection; the traditional Chinese medicine extract is composed of the following raw materials in parts by mass: 10 parts of Cnidium monnieri, 15 parts of Phellodendron amurense, 12 parts of Sophora flavescens, 8 parts of Menthol, 10 parts of Artemisia capillaris, 5 parts of Forsythia suspensa, 4 parts of Dictamnus cortex, 10 parts of Taraxacum mongolicum and 3 parts of Borneol; 1 part of the keratin softener; and 1200 parts of water for injection.

[0023] Furthermore, the keratin softener is polyhydroxy acid (PHA).

[0024] The preparation method comprises the following steps: weighing Cnidium monnieri, Phellodendron chinense, Sophora flavescens, Mentha, Artemisia capillaris, Forsythia suspensa, Dictamni cortex, Taraxacum officinale and Borneolum Syntheticum as needed; mixing the raw material components, adding water and boiling for 1 hour, wherein the amount of water added is 15 times the total weight of the raw materials; filtering the traditional Chinese medicine liquid, and concentrating the filtrate under reduced pressure, wherein the relative density of the filtrate after reduced pressure concentration is 1.0, and the pressure of reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract; and uniformly mixing the traditional Chinese medicine extract with a keratin softener and water for injection to obtain a medical ear canal cleaning solution for ear canal cleaning.

[0025] Furthermore, when filtering the Chinese medicine liquid, it is necessary to gradually increase the filtration mesh number, using 120 mesh, 180 mesh and 200 mesh respectively.

[0026] Example 3, a medical ear canal cleaning solution for ear canal cleaning, comprising a traditional Chinese medicine extract, a keratin softener and water for injection; the traditional Chinese medicine extract is composed of the following raw materials in parts by mass: 20 parts of Cnidium monnieri, 15 parts of Phellodendron amurense, 12 parts of Sophora flavescens, 8 parts of Menthol, 10 parts of Artemisia capillaris, 5 parts of Forsythia suspensa, 4 parts of Dictamni cortex, 10 parts of Taraxacum mongolicum and 3 parts of Borneol; 2 parts of the keratin softener; and 1200 parts of water for injection.

[0027] Furthermore, the keratin softener is polyhydroxy acid (PHA).

[0028] The preparation method comprises the following steps: weighing Cnidium monnieri, Phellodendron chinense, Sophora flavescens, Mentha, Artemisia capillaris, Forsythia suspensa, Dictamni cortex, Taraxacum officinale and Borneolum Syntheticum as needed; mixing the raw material components, adding water and boiling for 1 hour, wherein the amount of water added is 15 times the total weight of the raw materials; filtering the traditional Chinese medicine liquid, and concentrating the filtrate under reduced pressure, wherein the relative density of the filtrate after reduced pressure concentration is 1.0, and the pressure of reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract; and uniformly mixing the traditional Chinese medicine extract with a keratin softener and water for injection to obtain a medical ear canal cleaning solution for ear canal cleaning.

[0029] Furthermore, when filtering the Chinese medicine liquid, it is necessary to gradually increase the filtration mesh number, using 120 mesh, 180 mesh and 200 mesh respectively.

[0030] Example 4, a medical ear canal cleaning solution for ear canal cleaning, comprising a traditional Chinese medicine extract, a keratin softener and water for injection; the traditional Chinese medicine extract is composed of the following raw materials in parts by mass: 10 parts of Cnidium monnieri, 15 parts of Phellodendron amurense, 12 parts of Sophora flavescens, 8 parts of Menthol, 10 parts of Artemisia capillaris, 5 parts of Forsythia suspensa, 4 parts of Dictamnus cortex, 10 parts of Taraxacum mongolicum and 3 parts of Borneol; 2 parts of the keratin softener; and 1300 parts of water for injection.

[0031] Furthermore, the keratin softener is polyhydroxy acid (PHA).

[0032] The preparation method comprises the following steps: weighing parts of Cnidium monnieri, Phellodendron chinense, Sophora flavescens, Mentha, Artemisia capillaris, Forsythia suspensa, Dictamni cortex, Taraxacum officinale and borneol as needed; mixing the raw material components, adding water and boiling for 1 hour, wherein the amount of water added is 15 times the total weight of the raw materials; filtering the traditional Chinese medicine liquid, and concentrating the filtrate under reduced pressure, wherein the relative water density of the filtrate after reduced pressure concentration is 1.0, and the pressure of reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract.

[0033] Furthermore, when filtering the Chinese medicine liquid, it is necessary to gradually increase the filtration mesh number, using 120 mesh, 180 mesh and 200 mesh respectively.

[0034] Performance Testing The external auditory canals of the affected sides of 110 patients were irrigated with a combination of medical ear canal cleaning solution and 75% medical alcohol.

[0035] The medical ear canal cleaning solution prepared in Example 1 and warm water were mixed in a ratio of 1:1. The patient's affected external auditory canal was then bathed 2 to 3 times daily for 7 to 10 consecutive days. Rigid otoscopy was then performed on the patient's affected external auditory canal. If the results of the rigid otoscopy showed no obvious exudate or fungal secretions in the patient's external auditory canal, the patient was treated further.

[0036] The patient's affected external auditory canal is irrigated with 75% medical alcohol. The specific method is to drip 75% medical alcohol into the patient's affected external auditory canal for 2 seconds, 1-2 times a day, for 20 consecutive days.

[0037] Among these 110 patients, 104 were cured and 6 were ineffective, with an overall effective rate of 94.55%.

[0038] Criteria for determining efficacy Cure: After treatment, the patient's clinical symptoms completely resolved, and there was no abnormal secretion or exudate in the external auditory canal. Rigid otoscopy revealed no fungal hyphae in the external auditory canal secretions, no inflammatory lesions in the external auditory canal, and no secretions adhering to the tympanic membrane. A smear examination of the ear canal secretions was negative for fungal hyphae.

[0039] Ineffective: After treatment, the patient's clinical symptoms improved, but the external auditory canal was damaged, the skin surface of the external auditory canal was abnormally colored, and abnormal secretions were present in the external auditory canal. Rigid otoscopy revealed inflammation of the eardrum and adhesions of the abnormal secretions. A smear examination of the ear canal secretions was positive for fungal hyphae.

[0040] The medical ear canal cleaning solution prepared in Example 1 of the present application is a pure traditional Chinese medicine preparation with anti-inflammatory and detoxifying effects, heat-clearing and dampness-removing, and insecticidal and antipruritic properties. 75% medical alcohol can effectively kill Candida albicans, pathogenic yeasts, intestinal pathogens, and pyogenic cocci, and is therefore commonly used for skin disinfection or surface disinfection. It is safe and easy to use, and can be used to treat outpatients, avoiding hospitalization for fungal otitis externa and reducing their financial burden.

[0041] The basic principles, main features, and advantages of the present invention are shown and described above. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

[0042] Any matters not described in detail in the present invention are well-known technologies to those skilled in the art.

Claims

1. A medical ear canal cleaning solution for cleaning the ear canal, characterized in that: The invention comprises a traditional Chinese medicine extract, a cuticle softener and water for injection; the traditional Chinese medicine extract is an extract of Cnidium monnieri, Phellodendron amurense, Sophora flavescens, Mentha, Capillaris ternata, Forsythia suspensa, Dictamnus dasycarpa, Taraxacum mongolicum and Borneol.

2. The medical ear canal cleaning solution for ear canal cleaning according to claim 1, characterized in that: The Chinese medicine extract is composed of the following raw materials in parts by weight: 10-20 parts of Cnidium monnieri, 12-15 parts of Phellodendron amurense, 10-12 parts of Sophora flavescens, 8-10 parts of Menthol, 8-10 parts of Artemisia capillaris, 5-8 parts of Forsythia suspensa, 4-5 parts of Dictamnus cortex, 8-10 parts of Taraxacum mongolicum, and 2-3 parts of Borneol; 1-2 parts of the keratin softener; The water for injection is 1100-1300 parts.

3. The medical ear canal cleaning solution for ear canal cleaning according to claim 2, characterized in that: The Chinese medicine extract is composed of the following raw materials in parts by mass: 15 parts of Cnidium monnieri, 12 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 8 parts of Menthol, 10 parts of Artemisia capillaris, 8 parts of Forsythia suspensa, 5 parts of Dictamni cortex, 10 parts of Taraxacum mongolicum and 3 parts of Borneol; 1 part of the keratin softener; and 1100 parts of water for injection.

4. The medical ear canal cleaning solution for ear canal cleaning according to claim 3, characterized in that: The keratin softener is a polyhydroxy acid (PHA).

5. A method for preparing a medical ear canal cleaning solution for cleaning the ear canal, characterized in that: The preparation method comprises the following steps: mixing the raw materials of the Chinese medicine composition according to claim 4 in parts by weight, decocting with water, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to obtain the Chinese medicine extract; and mixing the Chinese medicine extract with a keratin softener and water for injection to obtain a medical ear canal cleaning solution for ear canal cleaning.

6. The method for preparing the medical ear canal cleaning solution for ear canal cleaning according to claim 5, characterized in that: The preparation method comprises the following steps: weighing parts of Cnidium monnieri, Phellodendron chinense, Sophora flavescens, Mentha, Artemisia capillaris, Forsythia suspensa, Dictamni cortex, Taraxacum officinale and borneol as needed; mixing the raw material components, adding water and decocting for 1 hour, wherein the amount of water added is 10 to 20 times the total weight of the raw materials; filtering the traditional Chinese medicine liquid, and concentrating the filtrate under reduced pressure, wherein the relative density of the filtrate after reduced pressure concentration is 0.9 to 1.1, and the pressure of the reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract.

7. The method for preparing the medical ear canal cleaning solution for ear canal cleaning according to claim 6, characterized in that: When filtering Chinese medicine liquid, it is necessary to gradually increase the filtration mesh number, using 120 mesh, 180 mesh and 200 mesh respectively.

8. The method for preparing the medical ear canal cleaning solution for ear canal cleaning according to claim 7, characterized in that: The filtrate was concentrated under reduced pressure to a relative density of 1.0.