Super-smooth hydrogel and preparation method thereof

Abstract

The preparation method comprises the following steps: mixing 2-aminoethyl methacrylate hydrochloride, alpha, omega-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide, a photoinitiator and a cross-linking agent in a container, adding a crosslinking agent, a crosslinking agent, a crosslinking agent, a crosslinking agent, a crosslinking agent, a crosslinking agent and a crosslinking agent, and uniformly stirring to obtain the super-smooth hydrogel with the cross-linking agent and the 2-aminoethyl methacrylate hydrochloride and the alpha, omega-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide. Adding hydroxyethyl methylacrylate and deionized water, and magnetically stirring at room temperature until the hydroxyethyl methylacrylate and the deionized water are completely dissolved; introducing nitrogen into the container to remove oxygen, and performing ultrasonic treatment to obtain a precursor solution; and injecting the precursor solution into a mold, carrying out ultraviolet irradiation crosslinking, and finally sealing, refrigerating and storing. The friction coefficient of the super-smooth hydrogel is lower than 0.02, the friction coefficient is basically kept stable, the raw materials are low in price, and the used materials are non-toxic and environmentally friendly; according to the dynamic micelle self-assembly boundary lubrication hydrogel, a permanent polymer network and a dynamic self-repairing lubrication interface are constructed, so that the long-acting stable lubrication function of the hydrogel is realized, and the application of a hydrogel material in the lubrication field is promoted.

Description

Technical Field

[0001] The present invention relates to a hydrogel and a preparation method thereof, in particular to a super-slippery hydrogel and a preparation method thereof. Background Art

[0002] Hydrogel is a material with high water content, good biocompatibility and tunable physical and chemical properties. Due to its unique properties, it has been widely used in many fields. Its three-dimensional network structure enables it to absorb and retain large amounts of water, showing excellent flexibility, biocompatibility and mechanical adjustability. These characteristics make hydrogels show great application potential in biomedicine, tissue engineering, sensors, flexible electronics and smart wearable devices. The application of hydrogels in the field of interface lubrication is particularly prominent. Its excellent lubrication properties and low friction coefficient make it of great value in articular cartilage repair, artificial joint lubrication and surface coating of medical devices. However, during long-term use, the lubrication properties of traditional hydrogels will significantly decrease due to friction loss and damage to the surface structure, resulting in shortened service life and functional failure. This problem seriously limits the promotion and use of hydrogel materials in practical applications. Summary of the Invention

[0003] Purpose of the invention: In order to overcome the deficiencies in the prior art, the purpose of the present invention is to provide a method for preparing a super-slippery hydrogel with dynamic self-assembly of micelles. Another purpose of the present invention is to provide a super-slippery hydrogel with good lubricity, strong load-bearing capacity and self-repairing function.

[0004] Technical solution: The method for preparing a super-slippery hydrogel according to the present invention comprises the following steps:

[0005] Step 1: 2-aminoethyl methacrylate hydrochloride (AMA·HCl), α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide (F127-CHO), a photoinitiator, and a crosslinker are mixed in a container, and then hydroxyethyl methacrylate (HEMA) and deionized water are added and mixed evenly;

[0006] Step 2: nitrogen is introduced into the container to remove oxygen, followed by ultrasonication to obtain a precursor solution;

[0007] Step three: inject the precursor solution into a polytetrafluoroethylene mold, perform ultraviolet light cross-linking, and finally seal and refrigerate to obtain a super-smooth hydrogel.

[0008] Furthermore, in step 1, the photoinitiator is 2959.

[0009] Furthermore, in step 1, the cross-linking agent is N,N'-methylenebisacrylamide (MBA) or polyethylene glycol diacrylate (PEGDA).

[0010] Furthermore, in step 1, the mass ratio of α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide, 2-aminoethyl methacrylate hydrochloride, photoinitiator, and crosslinking agent is 5:4~6:3~5:5~8.

[0011] Furthermore, in step 1, the mass ratio of hydroxyethyl methacrylate, α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide, and deionized water is 30:0.5:0.4-0.6.

[0012] Furthermore, in step 1, the purity of hydroxyethyl methacrylate is greater than 96%, and the purity of 2-aminoethyl methacrylate hydrochloride is greater than or equal to 98%.

[0013] Furthermore, in step 2, the time for introducing nitrogen is 5 to 10 minutes, and the introduction rate is 0.5 to 0.8 L / min.

[0014] Furthermore, in step 3, the wavelength of ultraviolet light for ultraviolet crosslinking is 365 nm and the intensity is 120-130 mJ / cm 2 , the lighting time is 2.3 to 2.5 hours.

[0015] Furthermore, in step three, the refrigeration temperature is 3-10°C.

[0016] The super-slippery hydrogel described in the present invention has a friction coefficient of less than 0.02.

[0017] Preparation Principle: HEMA and AMA·HCl are hydrophilic monomers, and MBA or PEGDA is used as a bifunctional crosslinker. Under UV light, photoinitiator 2959 initiates a free radical copolymerization reaction to form a permanent covalently crosslinked polymer network, poly(hydroxyethyl methacrylate-co-2-aminoethyl methacrylate) hydrochloride (P(HEMA-co-AMA·HCl)). AMA·HCl, a hydrophilic monomer containing amino groups, protonates the amino groups, enhancing interfacial hydration strength and surface hydrophilicity, endowing P(HEMA-co-AMA·HCl) with superior lubricity. At the same time, the network provides mechanical support and structural stability for the hydrogel through the addition polymerization reaction of the acrylate double bond, preventing the gel from disintegrating when swelling or under stress. The introduction of F127-CHO, under human physiological conditions (pH 7.4), the amino group (-NH2) of AMA·HCl and the aldehyde group (-CHO) of F127-CHO form dynamic covalent bonds (-C=N-) through the pH-sensitive Schiff base reaction, making the F127-CHO micelles and the main cross-linked network P(HEMA-co-AMA·HCl) dynamically associates via Schiff base bonds. F127-CHO, an amphiphilic triblock copolymer (α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide), dissolves and disperses in water at low temperatures. At elevated temperatures (above the critical micelle temperature), it self-assembles, forming spherical micelles at 37°C, composed of hydrophobic polypropylene oxide segments as the hydrophobic core and hydrophilic aldehyde-terminated polyethylene oxide as the hydrophilic shell. Under human physiological conditions, the hydrophilic shell of the F127-CHO micelles further optimizes the interfacial lubrication. Furthermore, after the interface is damaged by external forces such as friction and compression, the damaged F127-CHO micelles and P(HEMA-co-AMA·HCl) polymer chains can dynamically reassociate with the surface via Schiff base bonds, endowing the interface with self-healing properties. The resulting hydrogel exhibits excellent properties of high load-bearing capacity, low friction, and self-healing properties.

[0018] Beneficial effects: Compared with the prior art, the present invention has the following significant features:

[0019] 1. The main raw material used is hydroxyethyl methacrylate, which is inexpensive, non-toxic, and environmentally friendly. The resulting super-slippery hydrogel, unlike lubricating hydrogel materials, achieves long-lasting and stable lubrication by constructing a permanent polymer network and a dynamic lubricating interface. It has a low friction coefficient, strong load-bearing capacity, and excellent scratch repair performance, promising long-term and superior applications in biomedical and engineering fields such as articular cartilage lubrication and repair.

[0020] 2. The hydrogel obtained by the present invention has good hydrophilicity. The designed and introduced AMA·HCl and F127-CHO micelles continuously optimize the hydrophilicity of the hydrogel, and the water contact angle of the super-slippery hydrogel surface is finally 8.62°;

[0021] 3. The hydrogel obtained by the present invention has excellent lubricity and can maintain a stable low friction coefficient under a wide range of high-low load changes, with a friction coefficient of less than 0.02;

[0022] 4. The hydrogel obtained by the present invention has excellent self-repairing properties. The friction scratches generated during long-term friction can be self-repaired, and the friction coefficient remains basically stable;

[0023] 5. The preparation method of the present invention is convenient and the process difficulty is significantly reduced. The "one-pot method" is adopted to prepare the super-slippery hydrogel in one step through photoinitiation. The prepared super-slippery hydrogel has stable performance, controllable reaction conditions and strong universality. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a test diagram of the friction performance of the hydrogel prepared in Example 1;

[0025] Figure 2 This is a test diagram of the friction performance of the hydrogel prepared in Comparative Example 1;

[0026] Figure 3 This is a test diagram of the friction performance of the hydrogel prepared in Comparative Example 2;

[0027] Figure 4 1 is a graph showing the water contact angle test results of the hydrogels prepared in Example 1, Comparative Example 1, and Comparative Example 2, wherein a is Comparative Example 1, b is Comparative Example 2, and c is Example 1;

[0028] Figure 5 1 is a diagram showing the compression test results of the hydrogels prepared in Example 1, Comparative Example 1 and Comparative Example 2;

[0029] Figure 6 1 is a graph showing the tensile test results of the hydrogels prepared in Example 1, Comparative Example 1, and Comparative Example 2;

[0030] Figure 7 is a graph showing the scratch test results of the hydrogel prepared in Example 1;

[0031] Figure 8 This is a graph showing the scratch test results of the hydrogel prepared in Comparative Example 1;

[0032] Figure 9 This is a graph showing the scratch test results of the hydrogel prepared in Comparative Example 2. DETAILED DESCRIPTION

[0033] In the following examples, the materials and reagents used, unless otherwise specified, can be obtained from commercial sources. Experimental methods without specific conditions in the examples are usually carried out under conventional conditions or those recommended by the manufacturer. W 4000Da. HEMA purity is greater than 96%, AMA-HCl purity is 98%, MBA purity is 99%, and photoinitiator 2959 purity is 98%.

[0034] The preparation method of F127-CHO is as follows: F127-CHO was synthesized via a Steglich esterification reaction of F127 with 4-formylbenzoic acid. First, a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer (20 g, 0.8 mmol), 4-formylbenzoic acid (1.8 g, 6 mmol), and 4-dimethylaminopyridine (0.1 g, 0.4 mmol) were dissolved in 120 mL of tetrahydrofuran (THF) and sonicated. Then, 40 mL of a THF solution containing N,N'-dicyclohexylcarbodiimide (3.2 g, 7.8 mmol) was added. After stirring at room temperature for 40 hours, the mixture was concentrated under vacuum and precipitated twice from diethyl ether. The resulting white solid was dried and dissolved in deionized water. After centrifugation, the supernatant was collected and freeze-dried to yield a white powder of α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide.

[0035] Example 1

[0036] A method for preparing a super-slippery hydrogel based on dynamic micelle self-assembly comprises the following steps:

[0037] (1) Weigh 0.05 g AMA·HCl, 0.05 g F127-CHO, 0.03 g photoinitiator 2959, and 0.05 g crosslinker MBA into a 20 ml transparent glass bottle, add 3 ml HEMA liquid and 0.5 ml deionized water, and mix well.

[0038] (2) Nitrogen gas was introduced at a rate of 0.5 L / min for 10 min to remove oxygen from the transparent glass bottle to obtain a precursor solution.

[0039] (3) The deoxygenated precursor solution is injected into a polytetrafluoroethylene mold that has been cleaned with acetone-ethanol-deionized water and blown dry. The mold containing the precursor solution is placed in a UV box (ultraviolet light box) for ultraviolet light crosslinking. The ultraviolet light wavelength is 365nm and the intensity is 120mJ / cm 2 , the lighting time is 2.5h.

[0040] (4) The hydrogel after illumination was taken out and sealed and refrigerated in a refrigerator at 5°C to obtain a super-smooth hydrogel.

[0041] The friction coefficient μ of the super-slippery hydrogel obtained in this example is 0.016.

[0042] Example 2

[0043] A method for preparing a super-slippery hydrogel based on dynamic micelle self-assembly comprises the following steps:

[0044] (1) Weigh 0.05 g AMA·HCl, 0.05 g F127-CHO, 0.03 g photoinitiator 2959, and 0.05 g crosslinker PEGDA into a 20 ml transparent glass bottle, add 3 ml HEMA liquid and 0.5 ml deionized water, and mix well.

[0045] (2) Nitrogen gas was introduced at a rate of 0.5 L / min for 10 min to remove oxygen from the transparent glass bottle to obtain a precursor solution.

[0046] (3) The deoxygenated precursor solution is injected into a polytetrafluoroethylene mold that has been cleaned with acetone-ethanol-deionized water and blown dry. The mold containing the precursor solution is placed in a UV box (ultraviolet light box) for ultraviolet light crosslinking. The ultraviolet light wavelength is 365nm and the intensity is 125mJ / cm 2 , the lighting time is 2.5h.

[0047] (4) The hydrogel after illumination was taken out and sealed and refrigerated in a refrigerator at 3°C ​​to obtain a super-smooth hydrogel.

[0048] The friction coefficient of the super-slippery hydrogel obtained in this example is 0.016.

[0049] Example 3

[0050] A method for preparing a super-slippery hydrogel based on dynamic micelle self-assembly comprises the following steps:

[0051] (1) Weigh 0.04 g AMA·HCl, 0.05 g F127-CHO, 0.05 g photoinitiator 2959, and 0.08 g crosslinker MBA into a 20 ml transparent glass bottle, add 3 ml HEMA liquid and 0.4 ml deionized water, and mix well.

[0052] (2) Nitrogen gas was introduced at a rate of 0.8 L / min for 10 min to remove oxygen from the transparent glass bottle to obtain a precursor solution.

[0053] (3) The deoxygenated precursor solution is injected into a polytetrafluoroethylene mold that has been cleaned with acetone-ethanol-ultrapure water and blown dry. The mold containing the precursor solution is placed in a UV box (ultraviolet light box) for ultraviolet light crosslinking. The ultraviolet light wavelength is 365nm and the intensity is 120mJ / cm 2 , the lighting time is 2.3h.

[0054] (4) The hydrogel after illumination was taken out and sealed and refrigerated in a refrigerator at 5°C to obtain a super-smooth hydrogel.

[0055] The friction coefficient of the super-slippery hydrogel obtained in this example is 0.017.

[0056] Example 4

[0057] A method for preparing a super-slippery hydrogel based on dynamic micelle self-assembly comprises the following steps:

[0058] (1) Weigh 0.06 g AMA·HCl, 0.05 g F127-CHO, 0.05 g photoinitiator 2959, and 0.08 g crosslinker PEGDA into a 20 ml transparent glass bottle, add 3 ml HEMA liquid and 0.6 ml deionized water, and mix well.

[0059] (2) Nitrogen gas was introduced at a rate of 0.6 L / min for 5 min to remove oxygen from the transparent glass bottle to obtain a precursor solution.

[0060] (3) The deoxygenated precursor solution is injected into a polytetrafluoroethylene mold that has been cleaned with acetone-ethanol-deionized water and blown dry. The mold containing the precursor solution is placed in a UV box (ultraviolet light box) for ultraviolet light crosslinking. The ultraviolet light wavelength is 365nm and the intensity is 130mJ / cm 2 , the lighting time is 2.4h.

[0061] (4) The hydrogel after illumination was taken out and sealed and refrigerated in a refrigerator at 8°C to obtain a super-smooth hydrogel.

[0062] The friction coefficient of the super-slippery hydrogel obtained in this example is 0.019.

[0063] Example 5

[0064] A method for preparing a super-slippery hydrogel based on dynamic micelle self-assembly comprises the following steps:

[0065] (1) Weigh 0.04 g AMA·HCl, 0.05 g F127-CHO, 0.04 g photoinitiator 2959, and 0.06 g crosslinker MBA into a 20 ml transparent glass bottle, add 3 ml HEMA liquid and 0.5 ml deionized water, and mix well.

[0066] (2) Nitrogen gas was introduced at a rate of 0.7 L / min for 7 min to remove oxygen from the transparent glass bottle to obtain a precursor solution.

[0067] (3) The deoxygenated precursor solution is injected into a polytetrafluoroethylene mold that has been cleaned with acetone-ethanol-deionized water and blown dry. The mold containing the precursor solution is placed in a UV box (ultraviolet light box) for ultraviolet light crosslinking. The ultraviolet light wavelength is 365nm and the intensity is 120mJ / cm 2 , the lighting time is 2.5h.

[0068] (4) The hydrogel after illumination was taken out and sealed and refrigerated in a refrigerator at 4°C to obtain a super-smooth hydrogel.

[0069] The friction coefficient of the super-slippery hydrogel obtained in this example is 0.017.

[0070] Comparative Example 1

[0071] A method for preparing a HEMA hydrogel comprises the following steps:

[0072] (1) Weigh 0.03 g of photoinitiator 2959 and 0.05 g of MBA into a 20 ml transparent glass bottle, add 3 ml of HEMA liquid and 0.5 ml of deionized water, and mix well.

[0073] (2) Nitrogen gas is introduced to remove oxygen from the transparent glass bottle to obtain a precursor solution.

[0074] (3) The deoxygenated precursor solution is injected into a polytetrafluoroethylene mold that has been cleaned with acetone-ethanol-deionized water and blown dry. The mold containing the precursor solution is placed in a UV box (ultraviolet light box) for ultraviolet light crosslinking.

[0075] (4) Take out the hydrogel after illumination and place it in a refrigerator at 5°C.

[0076] Comparative Example 2

[0077] A method for preparing a HEMA-(AMA-HCl) hydrogel comprises the following steps:

[0078] (1) Weigh 0.05 g AMA·HCl, 0.03 g photoinitiator 2959, and 0.05 g MBA into a 20 ml transparent glass bottle, add 3 ml HEMA liquid and 0.5 ml deionized water, and mix well.

[0079] (2) Nitrogen gas is introduced to remove oxygen from the transparent glass bottle to obtain a precursor solution.

[0080] (3) The deoxygenated precursor solution is injected into a polytetrafluoroethylene mold that has been cleaned with acetone-ethanol-deionized water and blown dry. The mold containing the precursor solution is placed in a UV box (ultraviolet light box) for ultraviolet light crosslinking.

[0081] (4) Take out the hydrogel after illumination and place it in a refrigerator at 5°C.

[0082] The ingredients of Example 1, Comparative Example 1 and Comparative Example 2 are summarized in Table 1 below.

[0083] Table 1 Ingredients for Example 1, Comparative Example 1 and Comparative Example 2

[0084] HEMA / ml AMA·HCl / g Photoinitiator / g MBA / g Deionized water / ml F127-CHO / g Example 1 3 0.05 0.03 0.05 0.5 0.05 Comparative Example 2 3 0 0.03 0.05 0.5 0 Comparative Example 3 3 0.05 0.03 0.05 0.5 0

[0085] Performance Testing

[0086] A. The friction coefficient of the hydrogel prepared in Example 1, Comparative Example 1 and Comparative Example 2 was tested. The friction coefficient was tested using the linear module of a friction and wear tester (Bruker, USA). The load was 1N, the sliding speed was 3mm / s, and the single-stroke sliding distance of the reciprocating sliding was 6mm. The measured friction force was divided by the applied normal force to obtain the friction coefficient of Example 1, Comparative Example 1 and Comparative Example 2 respectively. The prepared hydrogel was subjected to a friction coefficient test using a friction and wear tester, and the test results are shown in FIG. Figures 1 to 3 As shown, under a load of 1 N, the friction force of Example 1 is 0.016 N, and the friction coefficient μ of Example 1 is 0.016; the friction force of Comparative Example 1 is 0.035 N, and the friction coefficient μ of Comparative Example 1 is 0.035; the friction force of Comparative Example 2 is 0.026 N, and the friction coefficient μ of Comparative Example 2 is 0.026. Under the same pressure of 1 N, the friction coefficient of Example 1 is lower than that of Comparative Examples 1 and 2. In addition, the friction force curve of Example 1 is smoother and has less fluctuation than that of Comparative Examples 1 and 2. Therefore, the surface friction stability of Example 1 is better than that of Comparative Examples 1 and 2.

[0087] B. The water contact angle of the hydrogels prepared in Example 1, Comparative Example 1, and Comparative Example 2 was tested. The water contact angle was tested using a contact angle meter (Oxford, UK). Deionized water was dropped onto the horizontal surfaces of Example 1, Comparative Example 1, and Comparative Example 2 using a pipette. The surface water contact angle was measured after the water droplets stabilized. The test results are shown in Figure 2. Figure 4As shown, the water contact angle measured in Comparative Example 1 was 19.07°, the water contact angle measured in Comparative Example 2 was 10.42°, and the water contact angle measured in Example 1 was 8.62°. In summary, the synergistic effect of AMA·HCl and F127-CHO reduced the contact angle of the hydrogel in Example 1 to 8.62°, which was 56% and 17% lower than that in Comparative Example 1 (19.07°) and Comparative Example 2 (10.42°), respectively, confirming that the micelle dynamic self-assembly strategy can improve the interfacial hydrophilicity of the hydrogel.

[0088] C. Compression and tensile tests were performed on the hydrogels prepared in Example 1, Comparative Example 1, and Comparative Example 2. The compression and tensile properties were tested using a universal testing machine (Shimadzu Corporation, Japan). The compression and tensile samples of Example 1, Comparative Example 1, and Comparative Example 2 were fixed on the universal testing machine and the compression and tensile properties of the samples were tested. The results are shown in Figure 2. Figures 5 and 6 As shown, the elastic modulus of Example 1 is about 345 MPa, which is higher than 37 MPa and 273 MPa of Comparative Example 1 and Comparative Example 2. The compression modulus of Example 1 is 119.2 MPa, which is higher than 44.1 MPa and 53.9 MPa of Comparative Example 1 and Comparative Example 2. Comparative Example 1 has a high compression modulus due to a single covalent network; Comparative Example 2 achieves a response of increasing the compression modulus by sacrificing energy through dynamic bonds; Example 1 enhances the gel network density and overall toughness due to the dynamic polymerization of the F127-CHO micelles themselves and the dynamic association with the main network, thereby enhancing the elastic modulus and compression modulus. Therefore, the elastic modulus and compression modulus of Example 1 are higher than those of Comparative Example 1 and Comparative Example 2.

[0089] D. The hydrogels prepared in Example 1, Comparative Example 1, and Comparative Example 2 were subjected to a scratch test. The scratch test was conducted using a linear module of a friction and wear tester (Bruker, USA) with a load of 3 N, a sliding speed of 3 mm / s, and a single-stroke sliding distance of 6 mm. The scratch depth variation was obtained. The test results are shown in Table 2. Figures 7 to 9 As shown in the figure, through the data analysis of the friction scratch depth of the three groups of hydrogels, it was found that there were significant differences in the damage behavior of Comparative Examples 1, Comparative Example 2 and Example 1. The scratch depth of Control Examples 1 and 2 gradually increased and then stabilized, while the scratch depth of Example 1 first increased and then gradually decreased. In the initial stage, due to the local stress in the load contact area, surface microcracks and scratches were caused. The detached F127-CHO micelles had not yet completely covered the damaged area, so the scratch depth increased temporarily. Subsequently, the damaged surface entered the repair stage (depth reduction), and the damaged and detached F127-CHO micelles and P (HEMA-co-AMAHCl) polymer chains continued to dynamically associate with the surface again through Schiff base bonds in a body fluid simulation environment (pH 7.4, 37 ° C), filling the scratches and reducing wear.

[0090] In summary, compared with Comparative Examples 1 and 2, Example 1 has a better friction coefficient, friction stability, good hydrophilicity and self-repairing ability.

Claims

1. A method for preparing a super-slippery hydrogel, characterized in that: The following steps are involved: Step 1: 2-aminoethyl methacrylate hydrochloride, α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide, a photoinitiator, and a crosslinker are mixed in a container, and then hydroxyethyl methacrylate and deionized water are added, and magnetic stirring is performed at room temperature until the mixture is completely dissolved; Step 2: nitrogen is introduced into the container to remove oxygen, followed by ultrasonication to obtain a precursor solution; Step three: inject the precursor solution into a polytetrafluoroethylene mold, perform ultraviolet light cross-linking, and finally seal and refrigerate to obtain a super-smooth hydrogel.

2. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In the step 1, the photoinitiator is 2959.

3. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In the step 1, the cross-linking agent is N,N'-methylenebisacrylamide or polyethylene glycol diacrylate.

4. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In the step 1, the mass ratio of α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide, 2-aminoethyl methacrylate hydrochloride, photoinitiator, and crosslinking agent is 5:4-6:3-5:5-8.

5. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In the step 1, the mass ratio of hydroxyethyl methacrylate, α,ω-dialdehyde-terminated polyethylene oxide-block-polypropylene oxide-block-polyethylene oxide, and deionized water is 30:0.5:0.4-0.

6.

6. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In the step 1, the purity of hydroxyethyl methacrylate is greater than 96%, and the purity of 2-aminoethyl methacrylate hydrochloride is greater than or equal to 98%.

7. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In the step 2, the time for introducing nitrogen is 5 to 10 minutes, and the introduction rate is 0.5 to 0.8 L / min.

8. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In step 3, the wavelength of ultraviolet light for ultraviolet crosslinking is 365 nm and the intensity is 120-130 mJ / cm 2 , the lighting time is 2.3 to 2.5 hours.

9. The method for preparing a super-slippery hydrogel according to claim 1, wherein: In the step 3, the refrigeration temperature is 3-10°C.

10. The super-slippery hydrogel obtained by the preparation method of super-slippery hydrogel according to claims 1 to 9, characterized in that: The friction coefficient is less than 0.02.

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