Rodent eye fixing system and control method thereof

Abstract

The invention relates to the technical field of animal fixing devices, in particular to a rodent eye fixing system and a control method thereof.The rodent eye fixing system comprises a head clamping piece with the rotational freedom degree in the first direction; the two eye rod assemblies are oppositely arranged, the eye rod assemblies and the head clamping clamp are arranged in a T shape, and each eye rod assembly has the moving freedom degree in the second direction and the third direction; wherein the first direction, the second direction and the third direction are perpendicular to one another. According to the technical scheme, through cooperative cooperation of the head clamping piece and the two eye rod assemblies, accurate adjustment of three degrees of freedom is achieved, and accurate positioning of animal head postures and micron-sized adjustment of eyeball contact points can be achieved; the device has the advantages that the eye fixing precision is improved, breathing vibration is effectively restrained, the device is suitable for animals of different body types, and operation convenience is improved.

Description

Technical Field

[0001] The present disclosure relates to the technical field of animal fixation devices, and in particular to a rodent eye fixation system and a control method thereof. Background Art

[0002] Rodents such as mice, rats, and guinea pigs are crucial research subjects in ophthalmic disease model research. Researchers often use precision instruments such as microscopes, anterior segment / fundus cameras, and optical coherence tomography scanners to observe and manipulate the eyes of living animals. These procedures, including microsurgeries like retinal and corneal stroma injections, require extremely precise fixation of the animal's eyes.

[0003] There are currently many technical difficulties in the experimental process: First, experimental animals are usually fixed laterally on the laboratory table and rely on manual adjustment of their body position, which is not only cumbersome to operate, but also difficult to accurately calibrate the position of the eyeballs. Secondly, the animal's breathing can cause micron-level vibrations in the eyeballs, seriously affecting the accuracy of delicate operations such as puncture. Furthermore, the traditional fixation device adopts a rigid structure and a single design, which is not only unable to adapt to rodents of different sizes, but also easily causes damage to the animal's eye tissue. In addition, the existing fixation system lacks an effective multi-degree-of-freedom adjustment mechanism, making it difficult to achieve precise control of the eyeball position.

[0004] While some existing animal eye fixation devices exist, they generally suffer from low fixation efficiency, poor stability, and inadequate compatibility. Rigid fixation structures can easily injure the animal, while simple fixation methods cannot meet the stringent stability requirements of microsurgery. Especially during high-precision ocular procedures, minute vibrations caused by the animal's breathing can often lead to surgical failure or inaccurate data collection. Summary of the Invention

[0005] In order to solve the problems in the related art, the embodiments of the present disclosure provide a rodent eye fixation system and a control method thereof.

[0006] In a first aspect, an embodiment of the present disclosure provides a rodent eye fixation system, comprising:

[0007] a head clamp having a rotational degree of freedom along a first direction;

[0008] Two eyebar assemblies are arranged opposite to each other and are arranged in a T-shape with the head clamp, and each eyebar assembly has a degree of freedom of movement along the second direction and the third direction;

[0009] The first direction, the second direction and the third direction are perpendicular to each other.

[0010] According to an embodiment of the present disclosure, the head clamping member includes:

[0011] Oppositely arranged bite blocks and pressing blocks;

[0012] A first knob provided through the engaging block and the pressing block;

[0013] An elastic member located between the engaging block and the pressing block, and sleeved on the first knob;

[0014] The clamping frame has a moving space, one end of the engaging block is fixed in the moving space, and one end of the pressing block is movably arranged in the moving space.

[0015] According to an embodiment of the present disclosure, a flexible nose clip is provided at the front end of the compression block.

[0016] According to an embodiment of the present disclosure, it further includes:

[0017] The first slide has a degree of freedom of movement in a first direction. A second knob is provided on the first slide, and one end of the second knob is connected to the head clamping member.

[0018] According to an embodiment of the present disclosure, each eyebar assembly comprises:

[0019] Eye rod;

[0020] an eyebar fixing member, used for fixing the eyebar;

[0021] The second slide has a degree of freedom of movement in the second direction and the third direction, and the eyebar fixing member is arranged on the second slide.

[0022] According to an embodiment of the present disclosure, the eyebar comprises:

[0023] a first portion, fixed by the eyebar fixing member;

[0024] The second part is detachably connected to the first part.

[0025] According to an embodiment of the present disclosure, the front end of the second part is wrapped with silicone resin.

[0026] According to an embodiment of the present disclosure, a body placement seat is also included.

[0027] According to an embodiment of the present disclosure, the body placement seat is made of transparent material.

[0028] In a second aspect, the present disclosure also provides a method for controlling a rodent eye fixation system as described in any one of the first aspects, comprising the following steps:

[0029] adjusting the fixed position and angle of the rodent's head along a first direction;

[0030] The fixed position and angle of the adaptable head are adjusted along the second direction and the third direction.

[0031] The rodent eye fixation system provided by the embodiments of the present disclosure includes: a head clamp having rotational freedom along a first direction; two eye bar assemblies arranged opposite each other in a T-shape with the head clamp, each eye bar assembly having movement freedom along a second direction and a third direction; wherein the first direction, the second direction, and the third direction are mutually perpendicular. This technical solution, through the coordinated cooperation between the head clamp and the two eye bar assemblies, achieves precise adjustment of three degrees of freedom, enabling precise positioning of the animal's head posture and micrometer-level adjustment of the eye contact point. It has the advantages of improving eye fixation accuracy, effectively suppressing respiratory tremors, adapting to animals of different sizes, and enhancing operational convenience.

[0032] It is to be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Other features, objects and advantages of the present disclosure will become more apparent from the following detailed description of non-limiting embodiments taken in conjunction with the accompanying drawings.

[0034] Figure 1 A front view of a rodent eye fixation system according to an embodiment of the present disclosure is shown.

[0035] Figure 2 A top view of a rodent ocular fixation system according to an embodiment of the present disclosure is shown.

[0036] Figure 3 A side view of a rodent ocular fixation system is shown according to an embodiment of the present disclosure.

[0037] Figure 4 An exploded view of a rodent ocular fixation system according to an embodiment of the present disclosure is shown. DETAILED DESCRIPTION

[0038] Hereinafter, exemplary embodiments of the present disclosure will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily implement them. In addition, for the sake of clarity, parts not related to the description of the exemplary embodiments are omitted in the accompanying drawings.

[0039] In the present disclosure, it should be understood that terms such as "include" or "have" are intended to indicate the presence of features, numbers, steps, actions, components, parts, or combinations thereof disclosed in the present specification, and are not intended to exclude the possibility that one or more other features, numbers, steps, actions, components, parts, or combinations thereof exist or are added.

[0040] It should also be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present disclosure may be combined with each other. The present disclosure will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0041] In existing technologies, ophthalmic experimental procedures on rodents rely on manual adjustment of the animal's position, which results in low fixation efficiency and poor stability. Traditional fixation devices use a rigid structure and lack multi-directional adjustment capabilities, resulting in poor adaptability to different species. During the experiment, micro-movements caused by the animal's breathing are difficult to suppress, affecting the accuracy of microsurgery. For example, during retinal injection operations, the operator needs to repeatedly adjust the angle of the animal's head, and there is still a risk of eye displacement after fixation.

[0042] To address the aforementioned issues, the presently disclosed embodiments provide a rodent eye fixation system, comprising: a head clamp having rotational freedom along a first direction; two eyebar assemblies disposed opposite each other in a T-shape with the head clamp, each eyebar assembly having movement freedom along a second direction and a third direction; wherein the first, second, and third directions are perpendicular to each other. This technical solution, through the coordinated cooperation between the head clamp and the two eyebar assemblies, achieves precise adjustment of three degrees of freedom, enabling precise positioning of the animal's head posture and micrometer-level adjustment of the eye contact point. It offers the advantages of improved eye fixation accuracy, effective suppression of respiratory tremors, adaptability to animals of varying sizes, and enhanced operational convenience.

[0043] like Figures 1 to 4 As shown, the rodent eye fixation system includes: a head holder 3 having rotational freedom along a first direction, and two eyebar assemblies 6 arranged in a T-shape with the head holder 3. The two eyebar assemblies 6 are arranged opposite each other, and each eyebar assembly 6 has two mutually perpendicular degrees of freedom of movement along a second direction and a third direction. The first, second, and third directions are mutually perpendicular, and the three adjustment directions form an orthogonal coordinate system.

[0044] In the disclosed method, the rotational freedom of the head clamp 3 can be achieved by using a rotary joint with an angle scale, and the rotation accuracy is controlled by a worm gear transmission mechanism. This feature allows the animal's head to be tilted at a specific angle, adapting to the craniofacial tilt characteristics of different species. The movement freedom of the eyebar assembly 6 includes a linear displacement mechanism, which can be specifically achieved by using a precision ball screw in conjunction with a guide rail, and fine-tuned with a differential head. This structure enables the eyebar contact point to be accurately positioned within a plane, compensating for individual size differences. At the same time, it can also adapt to the adjustment of the head's rotational freedom, for example, adjusting the height of the two eyebar assemblies in the vertical plane for adaptation. The T-type setting refers to the spatial perpendicular relationship formed by the axes of the two eyebar assemblies and the axis of the head clamp.

[0045] According to an embodiment of the present disclosure, the head clamping structure 3 includes an engaging block 31 and a pressing block 32 arranged opposite each other, a first knob 33 extending therethrough, an elastic member 34 sleeved on the first knob 33, and a clamping frame 35 with a movable space. One end of the engaging block 31 is fixed within the movable space of the clamping frame 35, while one end of the pressing block 32 is movably disposed within the movable space.

[0046] In the disclosed method, the bite block 31 refers to a rigid support component for contacting one side of the animal's head. Specifically, it can be made of polycarbonate material, and its surface can be provided with anti-slip grooves to enhance friction. The clamping block 32 refers to a movable component that cooperates with the bite block 31 to form a clamping force. Specifically, it can be made of aluminum alloy, and its contact surface can be covered with a silicone layer to increase cushioning. The first knob 33 refers to an adjustment component with a threaded structure. Specifically, it can be made of stainless steel. The clamping block is driven by rotation to move toward the bite block to change the clamping distance. The elastic member 34 refers to a mechanical element that provides a buffering force. Specifically, it can be a coil spring sleeved on the outer surface of the first knob. When the knob is locked, it generates elastic deformation to absorb overload pressure. The clamping frame 35 refers to a frame that supports the clamping structure. Specifically, it can be a U-shaped metal frame. Its moving space is limited to the range of motion of the clamping block by a slide groove structure.

[0047] When the first knob 33 is rotated, its threaded structure pushes the pressure block 32 toward the bite block 31, generating a progressive clamping force through the compression deformation of the elastic member. The sliding groove structure of the clamping frame 35 allows the pressure block 32 to move within the movable space at the millimeter level, while the fixed position of the bite block 31 provides a reference point for the clamping operation. During the clamping process, the nonlinear compression characteristics of the elastic member ensure that when the clamping force reaches the set threshold, even if the knob is further rotated, the pressure will not increase significantly, thus preventing mechanical damage to the animal's head.

[0048] Through the above technical solution, this application effectively solves the problems of rigid materials damaging eye tissue and insufficient adjustment precision. The buffering effect of the elastic member controls the clamping pressure within a safe threshold, avoiding soft tissue contusion. The combination of the knob and the slide achieves a displacement adjustment accuracy of 0.1 mm, ensuring that the animal's eye can be accurately aligned with the microsurgical instrument.

[0049] According to an embodiment of the present disclosure, a flexible nose clip 36 is provided at the front end of the compression block 32 .

[0050] In the present disclosure, flexible nose clip 36 refers to a clamping component made of an elastic material, specifically silicone or rubber, which absorbs external pressure through its inherent compressibility. The provision of flexible nose clip 36 at the front end of the compression block 32 means that the flexible nose clip is mounted at the contact end of the compression block near the animal's nose, achieving stable fixation by adjusting the mechanical distribution of the clamping contact surface.

[0051] The flexible nose clamp elastically deforms when the clamping block applies clamping force. This deformation adapts to the animal's nasal anatomy, evenly distributing the clamping pressure across the contact area. When the animal experiences slight displacements due to breathing, the flexible material's hysteresis-rebound properties dynamically compensate for these displacements, avoiding localized stress concentrations caused by rigid contact. The flexible material's cushioning effect reduces peak clamping pressure, preventing vascular compression and epidermal contusions. Its flexible deformation properties accommodate differences in nasal size between species, such as the width of the nasal bridge between mice and rats, enabling stable fixation without the need for component replacement.

[0052] According to an embodiment of the present disclosure, the rodent eye fixation system further includes: a first slide 2 having freedom of movement in a first direction, a second knob 5 being provided on the first slide 2, and one end of the second knob 5 being connected to the head clamp 3.

[0053] In the disclosed embodiment, the first slide 2 is a movable base that supports the head clamp 3. Specifically, it can be implemented using a linear guide rail and slider structure. The guide rail's guiding action limits the movement trajectory of the head clamp 3, allowing the head clamp 3 to move back and forth along a first horizontal direction. Specifically, the second slide 2 can be driven to move back and forth along the first horizontal direction by operating the third knob 4.

[0054] The second knob 5 refers to a manual adjustment component with a threaded rod, which can be specifically realized by connecting a threaded pair with the first slide 2. By rotating the knob, the threaded rod is driven to produce axial displacement, thereby driving the head clamp 3 to rotate along the first direction. Specifically, the threaded rod of the second knob passes through the side wall of the slide and cooperates with the threaded hole in the slide, and the end of the knob is connected to the rotating shaft of the head clamp through a bearing. When the knob is rotated, the head clamp produces an angular deflection around the rotating axis. Due to the transmission ratio characteristics of the threaded pair, the operator's tiny hand rotation movement can be converted into a millimeter-level displacement, thereby realizing sub-millimeter-level angular adjustment of the head clamp.

[0055] Through the above technical solution, this application achieves single-handed precise adjustment of the rodent's head fixation position, solving the problems of low adjustment precision and cumbersome steps in traditional manual operations. In microsurgery scenarios, the operator can quickly fine-tune the head angle by rotating the second knob, avoiding the repeated operation of loosening and tightening the fixing device, while ensuring that the eyeball positioning accuracy meets the requirements of delicate operations such as puncture and injection.

[0056] According to an embodiment of the present disclosure, each eyebar assembly 6 includes an eyebar, an eyebar fixing member 10 for fixing the eyebar, and a second slide having movement freedom in the second and third directions, and the eyebar fixing member 10 is disposed on the second slide.

[0057] In the present disclosure, an eyebar refers to an operating component that directly contacts an animal's eye. Specifically, it can be implemented as a cylindrical rod structure, with its front end wrapped in a flexible material to reduce the risk of injury. In one embodiment, the eyebar includes a first portion 11 secured by an eyebar fixture 10 and a second portion 12 detachably connected to the first portion 11. In another embodiment, the eyebar can be a single unit without distinguishing between the first and second portions, which is not a limitation of this disclosure.

[0058] The eye bar fixing member 10 refers to a mechanical structure for clamping the eye bar, and can be specifically implemented by a clamp with a locking screw. The eye bar can be fixed and its angle adjusted by tightening the screw.

[0059] The second slide is a support component capable of bidirectional movement in both horizontal and vertical directions. Specifically, the second slide includes a horizontal slide 61 and a vertical slide 62. Operating the fourth knob 7 drives the horizontal slide 61 forward and backward along the second horizontal direction, while operating the fifth knob 8 drives the vertical slide 62 up and down along the third vertical direction.

[0060] Through this technical solution, the second slide has freedom of movement in the second and third directions. To accommodate the eye structures of animals of varying sizes, the horizontal and vertical displacements of the second slide can be adjusted separately to precisely align the eyebar with the animal's eye socket. The combined design of the eyebar holder and the second slide allows for a rigid, secure lock after positioning, preventing shifting during operation. Eyebars of varying lengths or diameters can be interchanged for different animal species without adjusting the overall slide structure. The clamping function of the eyebar holder accommodates a wide range of eyebar sizes.

[0061] According to the embodiments of the present disclosure, the first part 11 included in the eye rod refers to a basic support structure that forms a rigid connection with the eye rod fixing part, which can be specifically achieved by threaded locking of the metal rod body and the fixing part, and its function is to establish a stable positioning reference. The second part 12 included in the eye rod refers to a functional module that is in direct contact with the eye, which can be specifically achieved by plugging a contact end wrapped in medical silicone into the first part, and its function is to achieve eye protection and adaptive adjustment through material softening and structural replaceability. The detachable connection refers to a mechanical connection method between modules, which can be specifically achieved by a magnetic interface or a snap-on structure, and its function is to achieve rapid replacement of contact parts to adapt to different experimental needs.

[0062] According to an embodiment of the present disclosure, the front end of the second portion 12 included in the eyebar is wrapped with silicone resin.

[0063] Silicone resin coating involves covering the contact end of the eyebar with a flexible material. This can be achieved through compression molding, where silicone resin is attached to the metal substrate, creating a 0.5-1.2 mm thick coating. This material absorbs impact forces during contact between the device and tissue through its elastic deformation. The second section, the front end, is the area where the eyebar tip directly contacts the animal's eyeball. This can be designed as a hemispherical structure with a diameter of 2-3 mm, increasing the contact area and reducing local pressure.

[0064] The silicone resin coating forms a buffering interface at the end of the eye rod. When the eye rod contacts the animal's cornea, the silicone material compresses and deforms, distributing the contact pressure evenly over a larger area. During microsurgery, this structure prevents direct pressure from rigid metal on the eye surface while maintaining the grip required to secure the eye through the silicone's coefficient of friction.

[0065] According to an embodiment of the present disclosure, the eye fixation system for rodents further includes a body placement seat 9 .

[0066] In the present disclosure, the torso support 9 refers to a support structure used to support and restrain the torso of the experimental animal. Specifically, it can be made of a transparent material with a grooved plate or trough-shaped structure. The groove shape can adapt to the torso contours of animals of different sizes. This structure limits the horizontal displacement of the animal's torso by physically limiting it, while allowing for vertical movement caused by breathing, thereby reducing the impact of torso movement on the head.

[0067] The torso rest 9 is configured to form a spatial linkage with the head clamp and eyebar assembly. When the animal's torso is placed in the groove, its chest and abdomen contact and are constrained by the groove's sidewalls, while the head is fixed at a preset angle by the clamp, and the eyebar assembly abuts the surface of the eyeball. During breathing, the vertical movement of the torso is not completely restricted due to the longitudinal extension of the groove, but horizontal displacement is blocked by the groove's sidewalls, thereby suppressing the mechanical fluctuations of the torso's movement transmitted to the head through the spine. This three-level fixation system gradually reduces the freedom of movement of the animal's torso, head, and eyeball, ultimately maintaining submillimeter static stability of the eyeball during microsurgery.

[0068] According to the embodiments of the present disclosure, the torso support seat 9 is made of a transparent material. Transparent material refers to a solid material that allows visible light to penetrate, specifically polycarbonate or acrylic. Its transmittance must be at least 85% to meet visual observation requirements. The torso support seat is a support structure that supports the chest and abdomen of the experimental animal. It is specifically designed as a plate-like member with an arc-shaped depression, manufactured through a compression molding process. The arc of the depression matches the physiological curvature of the rodent spine.

[0069] During microsurgery, the animal's trunk is restrained in a transparent support frame. The optical transparency of the material allows researchers to observe the animal's respiratory fluctuations in the chest and abdomen, as well as the micro-movements of its extremities, directly through the support structure. During retinal microinjections, the operator can adjust the timing of the puncture based on the observed respiratory rhythm, effectively avoiding instrument vibration caused by respiratory movement. The transparent support structure also allows for accurate inspection of the animal's position while it is fixed, preventing ischemia caused by prolonged compression.

[0070] According to an embodiment of the present disclosure, the rodent eye fixation system further includes a fixation base 1 .

[0071] The first slide 2, the second slide, and the body support 9 are all mounted on the fixed base 1. The body support 9 is detachably fixed to the fixed base 1, so that the body support 9 can be used to first fix the driving part of the experimental animal, and then the body support 9 is connected to the experimental animal and fixed to the fixed base 1 together, and then the eye positioning operation is carried out.

[0072] The following is a specific example to illustrate how to use the fixation system disclosed herein to perform rodent ocular microsurgery experiments:

[0073] 1. First, select a magnetic detachable eye bar of appropriate size according to the size of the experimental animal (such as a mouse) and assemble the two parts of the eye bar together.

[0074] 2. Place the anesthetized mouse in the trunk holder and secure its head with a flexible nose clip. Using the second knob, adjust the angle of the nose clip to maintain the mouse's head in the desired position without causing any compression damage.

[0075] 3. Use the fourth and fifth buttons to precisely adjust the position of the mouse's eyeball. Make fine adjustments with an accuracy of 0.1mm each time until the eyeball is perfectly positioned for surgery.

[0076] 4. Adjust the position of the microscope or other surgical instruments and begin ocular microsurgery, such as retinal injection, corneal stroma injection, or suprachoroidal space injection.

[0077] 5. During the operation, even if the mouse has slight breathing movements, the stabilizing effect of the trunk fixator will greatly reduce the micro-movement of the eyeball, ensuring the accuracy of the operation.

[0078] 6. After the operation is completed, the magnetic eye rod and flexible nose clip can be easily removed to remove the mouse and complete the experiment.

[0079] In this way, the fixation system of the present invention achieves beneficial effects such as high stability, multi-species adaptability (compatible with mice, rats, and guinea pigs), improved safety, and automated operation, greatly improving the efficiency and success rate of rodent eye microsurgery experiments.

[0080] The present disclosure further proposes a control method for a rodent eye fixation system, comprising the following steps: adjusting the fixed position and angle of the rodent's head along a first direction; and adjusting the position of the eyebar assembly along a second direction and a third direction according to the fixed position and angle of the head.

[0081] In the disclosed method, the first direction adjustment refers to changing the spatial angle of the animal's head by a head clamp with rotational freedom, the second direction adjustment refers to the linear movement of the eyebar assembly in the horizontal plane, and the third direction adjustment refers to the linear movement of the eyebar assembly in the vertical direction.

[0082] During microsurgery, the animal's head is first positioned at the optimal surgical angle through rotational adjustments. Respiration-induced body movements are then absorbed by the head clamp's rotational buffer mechanism. Subsequently, based on the calibrated head posture, the eyebar assembly is positioned in three dimensions using orthogonally arranged second and third directional motion mechanisms, ensuring a precise match between the eyebar tip and corneal curvature. This step-by-step coordinated adjustment mechanism, utilizing spatial positioning compensation, suppresses micro-eye movements caused by respiratory interference while also accommodating differences in eye size across species through independent adjustments in orthogonal directions.

[0083] Through the above technical solution, this application effectively solves the dynamic stability problem of animal eyes caused by respiratory interference during microsurgery. The multi-degree-of-freedom step-by-step adjustment mechanism suppresses the influence of body fluctuations on eye positioning. At the same time, the independent adjustment function in orthogonal directions achieves precise adaptation to the eye sizes of different species, avoiding the risk of tissue damage caused by traditional rigid fixators.

[0084] The above description is merely a preferred embodiment of the present disclosure and an illustration of the technical principles employed. Those skilled in the art should understand that the scope of the invention herein is not limited to the technical solutions formed by the specific combination of the above-mentioned technical features, but also encompasses other technical solutions formed by any combination of the above-mentioned technical features or their equivalents without departing from the inventive concept. For example, a technical solution formed by replacing the above-mentioned features with (but not limited to) technical features having similar functions disclosed in this disclosure.

Claims

1. A rodent eye fixation system, characterized in that: include: a head clamp having a rotational degree of freedom along a first direction; Two eyebar assemblies are arranged opposite to each other and are arranged in a T-shape with the head clamp, and each eyebar assembly has a degree of freedom of movement along the second direction and the third direction; The first direction, the second direction and the third direction are perpendicular to each other.

2. The rodent eye fixation system according to claim 1, wherein: The head clamping member comprises: Oppositely arranged bite blocks and pressing blocks; A first knob provided through the engaging block and the pressing block; An elastic member located between the engaging block and the pressing block, and sleeved on the first knob; The clamping frame has a moving space, one end of the engaging block is fixed in the moving space, and one end of the pressing block is movably arranged in the moving space.

3. The rodent eye fixation system according to claim 2, wherein: The front end of the pressing block is provided with a flexible nose clip.

4. The rodent eye fixation system according to claim 1, wherein: Also includes: The first slide has a degree of freedom of movement in a first direction. A second knob is provided on the first slide, and one end of the second knob is connected to the head clamping member.

5. The rodent eye fixation system according to claim 1, wherein: Each eyebar assembly comprises: Eye rod; an eyebar fixing member, used for fixing the eyebar; The second slide has a degree of freedom of movement in the second direction and the third direction, and the eyebar fixing member is arranged on the second slide.

6. The rodent eye fixation system according to claim 5, wherein: The eyebar comprises: a first portion, fixed by the eyebar fixing member; The second part is detachably connected to the first part.

7. The rodent eye fixation system according to claim 6, wherein: The front end of the second part is wrapped with silicone resin.

8. The rodent eye fixation system according to claim 1, wherein: Also includes a torso seat.

9. The rodent eye fixation system according to claim 1, wherein: The body placement seat is made of transparent material.

10. The method for controlling the rodent eye fixation system according to any one of claims 1 to 9, wherein: The steps include: adjusting the fixed position and angle of the rodent's head along a first direction; The fixed position and angle of the adaptable head are adjusted along the second direction and the third direction.

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