Active plant extract paste and preparation method thereof

Abstract

The invention discloses vigor plant extraction cream and a preparation method thereof, and belongs to the technical field of external medicine preparations. The plant extract paste is composed of extracts of Chinese herbal medicines such as pseudo-ginseng, safflower, myrrh and frankincense and a yeast fermentation product filtrate, achieves the effects of warming channels and expelling cold, promoting blood circulation to remove blood stasis and softening tendons and removing stasis to relieve pain through a multi-target synergistic effect, and is suitable for people suffering from shoulder and neck pain, waist and leg pain and joint pain. The preparation method comprises the steps of raw material pretreatment, water decoction and extraction, ethanol extraction, component fusion, final blending and homogenization, sterilization and packaging and the like. The product is natural, safe, high in permeability and lasting in effect, and an effective relieving scheme is provided for people suffering from musculoskeletal pain.

Description

Technical Field

[0001] The present invention belongs to the technical field of external-use pharmaceutical preparations, and specifically relates to a vitality plant extract cream with Chinese herbal medicine extracts as the core ingredient and a preparation method thereof, which is suitable for conditioning sub-health conditions caused by pain and numbness in the shoulders, neck, waist, legs, joints and other parts. Background Art

[0002] Currently, topical analgesic products have the following problems: 1. Single efficacy: Most products contain only menthol or capsaicin, which can only temporarily relieve superficial symptoms; 2. Poor permeability: Traditional plasters and patches are prone to leaving residue on the skin, and the active ingredients are difficult to penetrate deeply into the lesions; 3. Irritation: Some products contain nonsteroidal anti-inflammatory drugs (such as diclofenac), which may cause skin allergies or stomach discomfort if used for a long time; 4. Short-lived effect: Warm-sensing products (such as heating patches) last for a short time (usually less than 2 hours) and need to be replaced frequently.

[0003] In order to solve the above problems, the present invention provides a multi-ingredient synergistic, deep-penetrating, and long-lasting soothing vitality plant extract cream. Summary of the Invention The purpose of the present invention is to provide a vitality plant extract cream and a preparation method thereof, which achieves multiple functions of warming the meridians and dispersing cold, promoting blood circulation and removing blood stasis, softening tendons and relieving pain through the synergistic effect of Chinese herbal medicines such as Panax notoginseng and safflower, and is suitable for people with shoulder, neck, waist, leg and joint pain.

[0004] Ingredients The vitality plant extract cream of the present invention is composed of the following raw materials in parts by weight: Panax notoginseng extract: 20-30 servings Efficacy: Disperses blood stasis and stops bleeding, reduces swelling and relieves pain, and inhibits the release of inflammatory factors (such as TNF-α, IL-6).

[0005] Safflower Extract: 15-25 servings Efficacy: Promote blood circulation and menstruation, disperse blood stasis and relieve pain, improve microcirculation disorders, and promote the excretion of metabolic waste.

[0006] Myrrh Extract: 12-20 servings Efficacy: Promotes blood circulation and relieves pain, reduces swelling and promotes tissue regeneration, relieves muscle spasms and joint stiffness.

[0007] Frankincense Extract: 10-18 servings Efficacy: Regulates Qi and activates blood circulation, relieves pain and eliminates toxins, and enhances tissue repair ability.

[0008] Ginger Extract: 8-15 servings Efficacy: Warms the meridians and dispels cold, promotes local blood circulation, and relieves rheumatic joint pain.

[0009] Saposhnikovia Divaricata Extract: 6-12 servings Efficacy: dispel wind and relieve exterior symptoms, eliminate dampness and relieve pain, and help relieve muscle soreness.

[0010] Gentiana Root Extract: 5-10 servings Efficacy: Clears away heat and detoxifies, removes dampness and relieves pain, and inhibits bacterial growth.

[0011] Artemisia argyi extract: 4-8 servings Efficacy: Warms the meridians and stops bleeding, dispels cold and relieves pain, and enhances the permeability of other ingredients.

[0012] Saccharomyces ferment filtrate: 3-6 servings Efficacy: Contains a variety of amino acids and probiotic metabolites, nourishes the skin and enhances barrier function.

[0013] Licorice Extract: 2-5 servings Efficacy: Anti-inflammatory and anti-allergic, relieves skin irritation and promotes transdermal absorption.

[0014] Centella Asiatica Extract: 2-5 servings Efficacy: Repair damaged tissue, promote collagen synthesis, and improve skin elasticity.

[0015] Angelica Extract: 2-5 servings Efficacy: Nourishes blood and activates blood circulation, regulates menstruation and relieves pain, and enhances local blood circulation.

[0016] Preparation method 1. Raw material pretreatment: Dry and grind Panax notoginseng, safflower, myrrh, frankincense, ginger, siler, gentian root, mugwort leaf, and angelica, and pass through a 60-mesh sieve for later use; The yeast fermentation product filtrate is centrifuged and concentrated to a solid content of ≥15%; Glycyrrhiza inflata and Centella asiatica are extracted using supercritical CO2 extraction method to ensure that the active ingredient retention rate is ≥90%.

[0017] 2. Extraction and concentration: Water decoction extraction: add the pretreated plant powder (such as Panax notoginseng) to purified water at a material-liquid ratio of 1:8, decoct at 85°C for 2.5 hours, and filter to obtain the first extract; repeatedly decoct the residue at a material-liquid ratio of 1:6 for 1.5 hours, combine the two extracts, and concentrate to a relative density of 1.12-1.16 (60°C).

[0018] Ethanol extraction: Add an equal volume of 80% ethanol to the concentrated water extract, let it stand for 24 hours, filter to remove the precipitate, and recover the ethanol until there is no alcohol taste to obtain a concentrated solution with a total polysaccharide content ≥25%.

[0019] 3. Ingredient fusion: Preparation of basic paste: Mix the concentrate with the filtrate of yeast fermentation product, place in a vacuum emulsifier, and stir at 60 r / min until uniform to form a basic paste.

[0020] Add active ingredients: Add Glycyrrhiza inflata, Centella asiatica extract and Artemisia argyi extract in sequence, heat to 45°C, and stir at 200r / min for 30 minutes to ensure uniform dispersion.

[0021] Final adjustment and homogenization: cool to 35°C, add ginger extract and angelica extract, adjust the pH value to 5.8-6.2, and process twice with a high-pressure homogenizer (pressure 20MPa) to form a fine paste.

[0022] Sterilization and cooling: Sterilize with high-pressure steam at 121°C for 15 minutes, cool to room temperature and let stand for 24 hours to eliminate bubbles.

[0023] 4. Packaging and storage: The sterilized paste is divided into sterile aluminum tubes (specification 50g / tube), sealed and stored, with a shelf life of 24 months.

[0024] Beneficial Effects The vitality plant extract cream of the present invention has the following significant advantages: 1. Multi-target synergistic effect: Analgesic pathway: Panax notoginseng and myrrh inhibit COX-2 enzyme activity and reduce prostaglandin synthesis; Anti-inflammatory pathway: Frankincense and gentian root inhibit the NF-κB pathway and reduce the levels of inflammatory factors (such as IL-1β and PGE2); Penetration-enhancing pathways: Artemisia argyi and Glycyrrhiza uralensis open the gaps in the skin's stratum corneum, increasing the transdermal absorption rate of other ingredients (4-6 times higher than traditional products).

[0025] 2. Long-lasting mild fever: After gingerol in ginger extract comes into contact with the skin, it slowly releases heat (lasting 6-8 hours), and the temperature is controlled at 38-42°C to avoid low-temperature burns.

[0026] 3. Safe and non-irritating: Natural ingredients account for more than 98%, no hormones, no heavy metal residues; Human patch tests have shown that the incidence of redness and swelling in people with sensitive skin is less than 0.3%.

[0027] 4. Easy to use: The paste formulation is easy to apply and does not stain clothing; The effect can be further enhanced by combining it with massage techniques (such as kneading and pushing). DETAILED DESCRIPTION

[0028] The present invention is described in detail below through specific examples. Example

[0029] 1. Weigh the raw materials (parts by weight): 25 parts of Panax notoginseng extract, 20 parts of safflower extract, 15 parts of myrrh extract, 12 parts of frankincense extract, 10 parts of ginger extract, 8 parts of siler extract, 6 parts of gentian root extract, 5 parts of mugwort extract, 4 parts of yeast fermentation product filtrate, 3 parts of glycyrrhiza inflata extract, 2 parts of centella asiatica extract, and 2 parts of angelica extract.

[0030] 2. Preparation process: Pretreatment: The plant material was dried, crushed and sieved; the yeast filtrate was concentrated to 18% solids; the extraction pressure of Glycyrrhiza inflata and Centella asiatica was 20 MPa and the temperature was 40℃.

[0031] Extraction: decoct twice in water, combine the extracts and concentrate to a relative density of 1.14.

[0032] Fusion: The concentrate is mixed with the yeast filtrate and stirred in a vacuum emulsifier to form a basic paste.

[0033] Active ingredient addition: Add Glycyrrhiza inflata and Centella asiatica extracts in sequence, heat to 45°C and stir for 30 minutes.

[0034] Final homogenization: cool to 35°C, add ginger extract and angelica extract, adjust pH to 6.0, and perform high-pressure homogenization.

[0035] Sterilization packaging: Sterilize at 121℃ for 15 minutes and divide into aluminum tubes. Example

[0036] 1. Weigh the raw materials (parts by weight): 28 parts of Panax notoginseng extract, 18 parts of safflower extract, 12 parts of myrrh extract, 10 parts of frankincense extract, 8 parts of ginger extract, 6 parts of siler extract, 5 parts of gentian root extract, 4 parts of mugwort extract, 3 parts of yeast fermentation product filtrate, 2 parts of glycyrrhiza inflata extract, 1 part of centella asiatica extract, and 1 part of angelica extract.

[0037] 2. Preparation process: Pretreatment: The plant material was crushed and passed through an 80-mesh sieve; the yeast filtrate was concentrated to a solid content of 20%; the extraction pressure of Glycyrrhiza inflata and Centella asiatica was 25 MPa and the temperature was 45°C.

[0038] The extraction: water decoction material-liquid ratio was adjusted to 1:10, and the first decoction time was extended to 3 h.

[0039] Fusion: The concentrate is mixed with the yeast filtrate and stirred in a vacuum emulsifier to form a basic paste.

[0040] Active ingredient addition: Add Glycyrrhiza inflata and Centella asiatica extracts in sequence, raise the temperature to 43°C and stir for 25 minutes.

[0041] Final homogenization: cool to 33°C, add ginger extract and angelica extract, adjust pH to 5.9, and perform high-pressure homogenization.

[0042] Sterilization packaging: Sterilize at 115℃ for 20 minutes and divide into aluminum tubes.

Claims

1. A vitality plant extract cream, characterized in that: The invention is composed of the following raw materials in parts by weight: 20-30 parts of Panax notoginseng extract, 15-25 parts of safflower extract, 12-20 parts of myrrh extract, 10-18 parts of frankincense extract, 8-15 parts of ginger extract, 6-12 parts of siler extract, 5-10 parts of gentian root extract, 4-8 parts of mugwort extract, 3-6 parts of yeast fermentation product filtrate, 2-5 parts of glycyrrhiza inflata extract, 2-5 parts of Centella asiatica extract, and 2-5 parts of angelica extract.

2. The active plant extract cream according to claim 1, characterized in that The content of notoginsenoside R1 in the Panax notoginseng extract is ≥2.0%; the content of β-bisabolene in the myrrh extract is ≥1.5%.

3. A method for preparing the vitality plant extract cream according to claim 1 or 2, characterized in that: The following steps are involved: Raw material pretreatment: Dry and crush the Panax notoginseng and other plant materials and then pass them through a 60-80 mesh sieve; the filtrate of the yeast fermentation product is centrifuged and concentrated; Glycyrrhiza inflata and Centella asiatica are extracted by supercritical CO2 extraction; Water decoction extraction: add purified water at a solid-liquid ratio of 1:8-1:10, decoct at 85°C for 2-3 hours, filter and repeat the decoction once, combine the extracts and concentrate to a relative density of 1.12-1.16; Ethanol extraction: add an equal volume of 80% ethanol to the concentrate, let it stand, filter and recover the ethanol; Ingredient fusion: The treated extract is mixed with the filtrate of the yeast fermentation product, and vacuum emulsified and stirred to form a base paste; Add active ingredients: Add Glycyrrhiza inflata, Centella asiatica extract and Artemisia argyi extract in sequence, heat and stir; Final adjustment and homogenization: After cooling, add ginger extract and angelica extract, adjust the pH value to 5.8-6.2, and process with a high-pressure homogenizer; Sterilization and cooling: After high pressure steam sterilization, cool and let stand; Packaging and storage: Divide into sterile aluminum tubes and store in sealed containers.

4. The production method according to claim 3, characterized in that: The stirring speed of the vacuum emulsifying pot is 50-80 r / min, and the stirring time is 20-30 minutes; the pressure of the high-pressure homogenizer is 15-25 MPa, and the number of treatments is 1-3 times.