Chip sequencer and chip motion platform

By setting a rotary adjustment component on the chip motion platform of the sequencer, the direction of the chip flow channel is adjusted to be parallel to the motion direction, which solves the problem of inaccurate chip photography and improves detection accuracy and chip area utilization.

CN120679623APending Publication Date: 2025-09-23GUANGDONG RUNPENG BIOLOGICAL TECH CO LTD +1
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Patent Information

Application Number
CN202410330425.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-03-21
Publication Date
2025-09-23

AI Technical Summary

Technical Problem

The chip motion platform of existing sequencers cannot be adjusted, resulting in a deviation between the length direction of the chip flow channel and the motion direction, causing inaccurate photography and affecting the detection results.

Method used

A rotation adjustment component is set on the chip motion platform. By adjusting the rotation angle of the carrier, the length direction of the chip flow channel is parallel to the motion direction to ensure the accuracy of photography.

Benefits of technology

By using the rotary adjustment component, installation errors are eliminated, ensuring that the chip flow channel is always located within the shooting area during the shooting process, thereby improving the accuracy of detection and chip area utilization.

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Abstract

The invention discloses a chip sequencer and a chip motion platform, the chip motion platform comprises a fixed table, a mobile table, a bearing table, a mobile driving member and a rotation adjusting assembly, the rotation adjusting assembly is connected with the bearing table, and the rotation adjusting assembly is used for adjusting the rotation angle of the bearing table relative to the mobile table. As the rotation angle of the bearing table relative to the moving table can be adjusted by the rotation adjusting assembly, after the bearing table is mounted on the moving table, the length direction of the flow channel of the chip on the bearing table can be adjusted to be consistent with the first moving direction of the bearing table through the rotation adjusting assembly, so that the flow channel of the chip can move along the first direction for photographing; the optical system can sequentially shoot along the length direction of the flow channel, the shooting area is always located in the flow channel, the shooting area does not shift to the outer side of the flow channel, the flow channel can be accurately shot, and the detection accuracy is improved.
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Description

Technical Field

[0001] The present invention relates to the technical field of biochip sequencing, and in particular to a chip sequencer and a chip motion platform. Background Art

[0002] The sequencer includes a chip stage, which is used to fix the chip and move the chip to enable the chip to be photographed.

[0003] The chip motion platform of most existing sequencers cannot be adjusted, and the chip motion platform has installation errors. When taking pictures of the chip on the chip platform, there is a tendency for the length direction of the chip flow channel to deviate from the movement direction, resulting in misalignment of the chip flow when taking pictures. The area outside the flow channel will be photographed instead of the target flow channel, which in turn leads to inaccurate detection. Summary of the Invention

[0004] The present application provides a chip sequencer and a chip motion platform to solve the problem of inaccurate photography during chip movement.

[0005] In one embodiment, a chip sequencer is provided, comprising:

[0006] A chip motion platform, comprising a fixed platform, a mobile platform, a carrier platform, a mobile driver, and a rotation adjustment assembly, wherein the mobile platform is movable along a first direction and is arranged on the fixed platform, the carrier platform is arranged on the mobile platform, the carrier platform is used to fix a carrier chip, the mobile driver is connected to the mobile platform, the mobile driver is used to drive the mobile platform and the carrier platform to move along the first direction, the rotation adjustment assembly is connected to the carrier platform, and the rotation adjustment assembly is used to adjust the carrier platform to rotate relative to the mobile platform, so as to adjust the length direction of the flow channel of the chip on the carrier platform to be parallel to the first direction;

[0007] a fluidic system connected to the flow channel of the chip on the carrier platform and used for injecting samples and / or reagents into the flow channel of the chip; and

[0008] The optical system is arranged above the carrier platform and is used to take pictures and images of the flow channel of the chip on the carrier platform.

[0009] In one embodiment, the rotation adjustment assembly includes an adjusting member, which can move along a second direction. The adjusting member is connected to the first side of the supporting platform. The second direction and the first direction are located in the same plane and are perpendicular to the first direction. The adjusting member moves along the second direction to drive the supporting platform to rotate.

[0010] In one embodiment, the rotation adjustment assembly further includes an elastic member, the elastic member abuts against a second side surface of the supporting platform, the second side surface is a surface facing away from the first side surface, and the elastic member is used to eliminate the reverse clearance of the rotation of the supporting platform.

[0011] In one embodiment, the adjusting member and the elastic member are arranged opposite to each other.

[0012] In one embodiment, the rotation adjustment assembly further includes a mounting member, the mounting member is disposed on the moving platform, and the adjustment member is disposed on the mounting member.

[0013] In one embodiment, the rotation adjustment assembly further includes a locking member, and the locking member is used to lock and fix the supporting platform to the fixing platform.

[0014] In one embodiment, the supporting platform is rotatably connected to the movable platform via a rotating shaft, and the adjusting member is used to adjust the supporting platform to rotate around the rotating shaft.

[0015] In one embodiment, a first bearing platform and a second bearing platform are provided on the movable platform, the first bearing platform and the second bearing platform are respectively provided with an adjusting member, and the first bearing platform and the second bearing platform correspond to the same elastic member.

[0016] In one embodiment, the elastic member is squeezed between the first bearing platform and the second bearing platform, one end of the elastic member is connected to the first bearing platform, and the other end of the elastic member is connected to the second bearing platform.

[0017] In one embodiment, a chip motion platform is provided, comprising:

[0018] Fixed table;

[0019] a movable platform, the movable platform being movable along a first direction and being disposed on the fixed platform;

[0020] A carrier platform, which is disposed on the mobile platform and is used to fix the carrier chip;

[0021] a moving drive member connected to the moving platform and configured to drive the moving platform and the carrying platform to move along the first direction; and

[0022] A rotation adjustment component is connected to the carrier platform, and is used to adjust the carrier platform to rotate relative to the movable platform to adjust the length direction of the flow channel of the chip on the carrier platform to be parallel to the first direction.

[0023] In one embodiment, a first supporting platform and a second supporting platform are provided on the movable platform, the rotation adjustment assembly includes an adjusting member and an elastic member, the first supporting platform and the second supporting platform are respectively provided with an adjusting member, and the first supporting platform and the second supporting platform correspond to the same elastic member.

[0024] According to the chip sequencer and chip motion platform of the above-mentioned embodiment, since a rotation adjustment component is provided on the chip motion platform, the rotation adjustment component can adjust the rotation angle of the carrier platform relative to the mobile platform. After the carrier platform is installed on the mobile platform, the rotation adjustment component can be used to adjust the length direction of the flow channel of the chip on the carrier platform to be consistent with the first direction of movement of the carrier platform, so that when the flow channel of the chip moves along the first direction to take pictures, the optical system can take pictures in sequence along the length direction of the flow channel, and the shooting area is always located in the flow channel. The shooting area will not be offset to the outside of the flow channel, so that the flow channel can be accurately photographed, thereby improving the accuracy of detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 A schematic diagram of the structure of a chip motion platform in one embodiment;

[0026] Figure 2 A schematic diagram of the structure of a chip motion platform in one embodiment;

[0027] Figure 3 A partial exploded view of a chip motion platform in one embodiment;

[0028] The accompanying drawings are numerals as follows:

[0029] 1-fixed platform, 11-first track, 12-second track, 2-movable platform, 3-carrying platform, 3a-first carrying platform, 3b-second carrying platform, 31-rotating shaft, 32-mounting slot, 4-rotation adjustment assembly, 41-mounting part, 42-adjusting part, 43-elastic part, 44-locking part, 5-chip, 51-flow channel. DETAILED DESCRIPTION

[0030] The present invention will be further described in detail below by means of specific embodiments in conjunction with the accompanying drawings. Similar elements in different embodiments are numbered with associated similar elements. In the following embodiments, many detailed descriptions are provided to enable the present application to be better understood. However, those skilled in the art will readily appreciate that some of the features may be omitted in different circumstances, or may be replaced by other elements, materials, or methods. In some cases, some operations related to the present application are not shown or described in the specification. This is to avoid the core portion of the present application being overwhelmed by excessive descriptions, and for those skilled in the art, it is not necessary to describe these related operations in detail. They will fully understand the related operations based on the description in the specification and the general technical knowledge in the art.

[0031] In addition, the features, operations, or characteristics described in the specification may be combined in any appropriate manner to form various embodiments. Furthermore, the steps or actions in the method description may be reordered or adjusted in a manner readily apparent to those skilled in the art. Therefore, the various sequences in the specification and drawings are provided solely for the purpose of clearly describing a particular embodiment and are not intended to be mandatory, unless otherwise specified.

[0032] The serial numbers assigned to components herein, such as "first," "second," etc., are used solely to distinguish the objects being described and do not convey any sequential or technical meaning. References to "connection" and "coupling" herein, unless otherwise specified, include both direct and indirect connections (couplings).

[0033] Current sequencers can handle tests with low chip utilization, primarily capturing images of the center of the chip. However, when increasing chip area utilization to improve test throughput and reduce testing costs, it becomes necessary to capture images of the vast majority of the chip area, with some images being taken very close to the edges of the flow channels. In this case, if the length of the chip's flow channels is not parallel to the direction of movement of the chip's motion platform, the edge of the flow channel may be captured outside the channel, or the edge of the flow channel may not be captured at all, resulting in inaccurate tests.

[0034] This application proposes a new chip motion platform, which can be rotated and adjusted. The moving direction of the chip motion platform can be adjusted to be parallel to the length direction of the chip flow channel to eliminate installation errors and ensure the accuracy of photography; at the same time, it can also reduce the difficulty of installing the chip motion platform.

[0035] Please refer to Figures 1 to 3In one embodiment, a chip motion platform is provided. This chip motion platform is used to carry a biological chip 5 and drive the chip 5 to move so as to take pictures of the objects to be tested in multiple flow channels in the chip 5 in sequence. This chip motion platform has a rotation adjustment function. The rotation adjustment function can adjust the direction of the flow channel of the chip 5 so that the length direction of the flow channel of the chip 5 is parallel to a movement direction of the chip motion platform, and then the chip motion platform can drive the chip 5 to move along the length direction of its flow channel to take pictures of the objects to be tested in the flow channel in sequence. It should be noted that the rotation adjustment function of the chip motion platform is performed during the installation process or maintenance process. The rotation adjustment function is used to eliminate installation errors. After the rotation adjustment of the chip motion platform, it is fixed and locked to ensure the stability of the position of the chip 5 on the chip motion platform; in other words, the rotation adjustment function of the chip motion platform is not performed during the detection process.

[0036] The chip 5 is a flat plate with multiple parallel flow channels 51 on its top. One end of the chip 5 has an inlet and the other has an outlet. Each flow channel 51 can have a separate inlet and outlet, or multiple channels 51 can share a common inlet or outlet. The flow channels 51 are used to provide a reaction or incubation area for analytes. For example, during gene sequencing, the flow channels 51 provide a reaction area for biological samples and reagents, where the reactants are the analytes. The upper ends of the flow channels 51 are covered with a transparent cover. This allows an optical system located above to photograph the analytes within the flow channels 51.

[0037] The chip motion platform mainly includes a fixed platform 1, a mobile platform 2, a carrier platform 3, a mobile drive component (not shown in the figure) and a rotation adjustment component 4. The fixed platform 1 can be a part of the frame of the chip sequencer, or the fixed platform 1 can be a platform installed on the frame. The top surface of the fixed platform 1 is a plane, and a first track 11 is provided on the fixed platform 1. The first track 11 extends along a first direction, that is, the length direction of the first track 11 is parallel to the first direction. The first direction is Figure 2 The fixed platform 1 may be provided with two parallel first rails 11 to improve the smoothness of sliding.

[0038] The mobile platform 2 can be a flat plate structure. The mobile platform 2 is installed on the first track 11. The lower end of the mobile platform 2 can be provided with a slider or a slide groove adapted to the first track 11. The lower end of the mobile platform 2 is slidably connected to the first track 11 through the slider or the slide groove. The mobile platform 2 can slide along the first track 11 relative to the fixed platform 1, that is, the mobile platform 2 can slide along the first direction relative to the fixed platform 1.

[0039] The mobile driving component is installed on the mobile platform 2. The mobile driving component can be a driving structure such as a cylinder or a linear motor. The output end of the mobile driving component is connected to the mobile platform 2. The mobile driving component is used to drive the mobile platform 2 to slide relative to the fixed platform 1 along the first direction.

[0040] In one embodiment, the mobile platform 2 can also move relative to the fixed platform 1 along a second direction, the second direction is in the same plane as the first direction, and the first direction and the second direction are perpendicular. Figure 1 The movable stage 2 can move relative to the second direction, that is, the chip motion platform can also drive the chip 5 to move along the second direction. During the imaging process, the chip motion platform can also drive the chip 5 to switch between different flow channels 51 along the second direction for imaging, and switch between different width areas of the same flow channel 51 for imaging, thereby realizing sequential imaging and inspection of multiple flow channels 51 on the chip 5. The first track 11 and the second track 12 each correspond to a movable drive component, one movable drive component for driving the movable stage 2 to move in the first direction, and the other movable drive component for driving the movable stage 2 to move in the second direction.

[0041] The second track 12 is installed on the fixed platform 1, and a track frame is installed on the second track 12. The first track 11 is installed on the track frame. The second track 12 is set along the second direction. The second direction is Figure 2 The X-axis direction is shown in FIG. Specifically, the fixed platform 1, the second rail 12, the rail frame, the first rail 11, and the movable platform 2 are installed in order from bottom to top. Of course, the positions of the first rail 11 and the second rail 12 can be interchanged. With the first rail 11 installed on the fixed platform 1 and the second rail 12 installed on the rail frame, the movable platform 2 can also be moved in the first and second directions.

[0042] In one embodiment, the chip motion platform may also include only the first track 11 , so as to realize photographic detection of a single flow channel 51 on the chip 5 .

[0043] In one embodiment, the carrier platform 3 can be rotatably mounted on the movable platform 2, and the lower middle end of the carrier platform 3 can be rotatably connected to the movable platform 2 by a rotating shaft 31. The carrier platform 3 can also be rotatably connected to the movable platform 2 by a connecting piece of a columnar or tubular structure. The rotating shaft 31 is perpendicular to the plane where the first direction and the second direction are located, so that the carrier platform 3 can rotate in a plane parallel to the plane where the first direction and the second direction are located. The top surface of the carrier platform 3 has a mounting groove 32, and the chip 5 is installed in the mounting groove 32. The mounting groove 32 can position and install the chip 5. The flow channel 51 of the chip 5 located on the carrier platform 3 is arranged parallel to the first direction. If the flow channel 51 of the chip 5 is not parallel to the first direction during the installation process, the flow channel 51 of the chip 5 can be adjusted to be parallel to the first direction by adjusting the carrier platform 3 to rotate relative to the movable platform 2.

[0044] The rotation adjustment component 4 is installed on the mobile platform 2, and the rotation adjustment component 4 is connected to the supporting platform 3. The rotation adjustment component 4 can be fixedly connected and abutted with the supporting platform 3. The rotation adjustment component 4 is used to drive the supporting platform 3 to rotate relative to the mobile platform 2 to adjust the rotation angle of the supporting platform 3 relative to the mobile platform 2.

[0045] The rotation adjustment assembly 4 may include a mounting member 41 and an adjusting member 42. The mounting member 41 may be a structure such as a fixed frame. The mounting member 41 is fixed on the movable platform 2. The adjusting member 42 may be movably mounted on the mounting member 41. The adjusting member 42 may move linearly along the second direction. One end of the adjusting member 42 abuts against or is fixedly connected to the side of the supporting platform 3, and the connection point between the adjusting member 42 and the supporting platform 3 is in an eccentric position of the supporting platform 3, so that the adjusting member 42 can drive the supporting platform 3 to rotate relative to the movable platform 2 during the movement of the adjusting member 42 along the second direction.

[0046] In one embodiment, the rotation adjustment assembly 4 may not include the mounting member 41. A raised mounting structure is provided on the mobile platform 2, and the adjustment member 42 can be movably mounted on the mounting structure of the mobile platform 2. The installation of the adjustment member 42 and the rotation adjustment of the supporting platform 3 can also be realized.

[0047] In one embodiment, the rotation adjustment assembly 4 may further include an elastic member 43, and the elastic member 43 is connected to the support platform 3. The support platform 3 includes a first side surface and a second side surface that are opposite and parallel to each other, the adjustment member 42 is connected to the first side surface of the support platform 3, and the elastic member 43 is connected to the second side surface of the support platform 3, and the adjustment member 42 and the elastic member 43 are at the same end of the support platform 3, so that the adjustment member 42 and the elastic member 43 can drive the support platform 3 to rotate in opposite directions, and the elastic member 43 is used to adjust the reverse clearance of the rotation of the support platform 3 to achieve adjustment angle compensation for the adjustment member 42 and improve the adjustment accuracy. For example, the adjustment member 42 can be used to adjust the driving support platform 3 to rotate clockwise, and the elastic member 43 can be used to adjust the support platform 3 to rotate counterclockwise, where clockwise and counterclockwise are the rotation directions of the support platform 3 when viewed from above. Of course, the positions of the adjusting member 42 and the elastic member 43 can be interchanged. The adjusting member 42 is connected to the second side of the carrier 3, and the elastic member 43 is connected to the first side of the carrier 3. The adjusting member 42 can be used to adjust the drive carrier 3 to rotate counterclockwise, and the elastic member 43 can be used to adjust the carrier 3 to rotate clockwise. The adjusting member 42 belongs to active drive adjustment, and the elastic member 43 belongs to passive drive adjustment. When the adjusting member 42 actively applies a driving force to the carrier 3, the elastic member 43 is forced to compress. When the adjusting member 42 withdraws the active driving force, the elastic member 43 will output a passive driving force to the carrier 3. The combination of the adjusting member 42 and the elastic member 43 can realize the adjustment of the rotation of the carrier 3 in two different directions. Regardless of whether the flow channel 51 of the chip 5 on the carrier 3 is biased to the left or right relative to the first direction, it can be adjusted to be parallel by the adjusting member 42 and the elastic member 43.

[0048] The adjusting member 42 can be a structure such as a screw. The mounting member 41 has a threaded hole, into which the screw is installed. The screw is movable along the second direction, with one end of the screw abutting the first side surface of the support platform 3. The elastic member 43 can be an elastic structure such as a spring. The spring is always in a compressed state, allowing it to continuously apply pressure to the support platform 3. The elastic member 43 not only drives the support platform 3 to rotate counterclockwise but also acts as a drive compensation for the adjusting member 42, thereby improving the precision of the rotation driven by the adjusting member 42 and positioning the support platform 3 more accurately.

[0049] In one embodiment, the rotation adjustment component 4 may also not include the elastic member 43. The adjustment member 42 has a threaded rod with an external thread, and the support platform 3 is provided with a threaded hole. The threaded rod is connected to the threaded hole of the support platform 3. The adjustment member 42 can drive the support platform 3 to rotate in different directions by forward and reverse rotation, that is, the length direction of the flow channel 51 of the chip 5 on the support platform 3 can be adjusted to be parallel to the first direction through the adjustment member 42.

[0050] In one embodiment, two carriers 3 can be provided on the movable platform 2, and the movable platform 2 can simultaneously drive the two carriers 3 to move in a first direction and a second direction. The carriers 3 are provided with a first carrier 3a and a second carrier 3b, which are arranged side by side. The first carrier 3a and the second carrier 3b are each used to support and fix a chip 5, and the flow channels 51 of the chips 5 on the first carrier 3a and the second carrier 3b are arranged in parallel.

[0051] The first carrier platform 3a and the second carrier platform 3b are respectively provided with a rotation adjustment component 4, that is, the first carrier platform 3a and the second carrier platform 3b can be rotationally adjusted separately. The first side surface of the first carrier platform 3a and the first side surface of the second carrier platform 3b are arranged in parallel with each other, and the second side surface of the first carrier platform 3a and the second side surface of the second carrier platform 3b are arranged face to face and in parallel. The first carrier platform 3a and the second carrier platform 3b can be adjusted by two adjustment members 42 and an elastic member 43. The first carrier platform 3a and the second carrier platform 3b are respectively provided with an adjustment member 42, and the first carrier platform 3a and the second carrier platform 3b share an elastic member 43, and the elastic member 43 is located between the second side surface of the first carrier platform 3a and the second side surface of the second carrier platform 3b. Since the first carrier platform 3a and the second carrier platform 3b can be staggered and adjusted separately, that is, they are not adjusted at the same time, when the elastic member 43 located at the first carrier platform 3a and the second carrier platform 3b is adjusted, the position accuracy of the other will not be affected. Two adjusting members 42 and an elastic member 43 are located at the same end of the first and second support platforms 3a, 3b. These two adjusting members 42 and the elastic member 43 are aligned on a straight line parallel to the second direction. One adjusting member 42 is used to adjust the clockwise rotation of the first support platform 3a, while the elastic member 43 is used to adjust the counterclockwise rotation of the first support platform 3a. The other adjusting member 42 is used to adjust the counterclockwise rotation of the second support platform 3b, while the elastic member 43 is also used to adjust the clockwise rotation of the second support platform 3b.

[0052] In one embodiment, a supporting platform 3 can also be set on the mobile platform 2, and the elastic member 43 can be installed on the mobile platform 2, one end of the elastic member 43 is fixed on the mobile platform 2, and the other end of the elastic member 43 is connected to the supporting platform 3, or a mounting member is provided on the mobile platform 2 for mounting the elastic member 43, both of which can realize the connection between the elastic member 43 and the second side of the supporting platform 3.

[0053] In one embodiment, the rotation adjustment assembly 4 may further include a locking member 44. The locking member 44 may be a locking screw or a locking pin. A mounting hole may be provided on the support platform 3. The locking member 44 is installed in the mounting hole of the support platform 3. The mounting hole may be an arc-shaped hole. A threaded hole perpendicular to the mobile platform 2 is provided on the surface of the mobile platform 2 facing the support platform. The end of the locking member 44 is connected to the threaded hole of the mobile platform 2. When the support platform 3 needs to be adjusted, the locking member 44 is loosened and separated from the mobile platform 2 so that the support platform 3 can rotate relative to the mobile platform 2. When the adjustment is completed, the locking member 44 is locked and connected to the mobile platform 2 to fix the position relationship of the support platform 3 relative to the mobile platform 2 to maintain the precise position of the support platform 3 after adjustment. The arc-shaped hole of the support platform 3 can prevent the support platform 3 from rotating relative to the locking member 44 during the rotation adjustment process. Of course, the locking member 44 can also be installed on the movable platform 2 and locked with the supporting platform 3, that is, an arc hole is provided on the movable platform 2, and a threaded hole facing the movable platform 2 is provided on the supporting platform 3, which can also realize the locking and unlocking of the supporting platform 3 relative to the movable platform 2.

[0054] In one embodiment, the locking member 44 can also be a clamping member or other structure, and the clamping member has an upper clamping jaw and a lower clamping jaw that can move relatively. The locking member 44 can clamp and fix the movable platform 2 and the supporting platform 3 in the up and down directions through the upper clamping jaw and the lower clamping jaw, and can also realize the locking and unlocking of the supporting platform 3 relative to the movable platform 2.

[0055] A plurality of locking members 44 may be provided on a supporting platform 3 , and a locking member 44 may be provided at each of the four corners of the square supporting platform 3 . The provision of multiple locking members 44 may improve the locking force between the supporting platform 3 and the movable platform 2 , thereby ensuring the position accuracy of the supporting platform 3 .

[0056] In one embodiment, a chip sequencer is provided, comprising the chip motion platform of any of the above embodiments, the chip sequencer further comprising a fluidic system and an optical system, and of course, other components such as a controller.

[0057] The liquid path system is used to connect with the flow channel 51 of the chip 5 on the supporting platform 3. The liquid path system is also connected to the liquid reservoir or liquid storage cavity. The liquid path system can inject samples or reagents in the liquid reservoir or liquid storage cavity into the flow channel 51 of the chip 5. The liquid path system can also inject samples and reagents into the flow channel 51 of the chip 5 successively.

[0058] The optical system is arranged above the carrier platform 3 . The optical system has an imaging lens. The imaging lens is arranged downward and is used to take pictures and images of the flow channel 51 of the chip 5 on the carrier platform 3 .

[0059] During the inspection and imaging process, the chip motion platform can drive the carrier 3 to move along the first direction and the second direction to sequentially image the multiple flow channels 51 of the chip 5. The chip motion platform has a rotation adjustment function, which can adjust the longitudinal direction of the flow channels 51 of the chip 5 to be parallel to the first direction, allowing the imaging lens to accurately capture the flow channels 51 in sequence along the first direction, ensuring the accuracy of the imaging inspection.

[0060] The above examples are used to illustrate the present invention, which are only used to help understand the present invention and are not intended to limit the present invention. Those skilled in the art can make several simple deductions, modifications or substitutions based on the concept of the present invention.

Claims

1. A chip sequencer, characterized in that: include: A chip motion platform, comprising a fixed platform, a mobile platform, a carrier platform, a mobile driver, and a rotation adjustment assembly, wherein the mobile platform is movable along a first direction and is arranged on the fixed platform, the carrier platform is arranged on the mobile platform, the carrier platform is used to fix the carrier chip, the mobile driver is connected to the mobile platform, the mobile driver is used to drive the mobile platform and the carrier platform to move along the first direction, the rotation adjustment assembly is connected to the carrier platform, and the rotation adjustment assembly is used to adjust the rotation angle of the carrier platform relative to the mobile platform; a fluidic system connected to the flow channel of the chip on the carrier platform and used for injecting samples and / or reagents into the flow channel of the chip; as well as The optical system is arranged above the carrier platform and is used to take pictures and images of the flow channel of the chip on the carrier platform.

2. The chip sequencer according to claim 1, wherein The rotation adjustment component is used to adjust the length direction of the flow channel of the chip on the carrier to rotate parallel to the first direction.

3. The chip sequencer according to claim 1, wherein The rotation adjustment assembly includes an adjusting member, which can move along a second direction. The adjusting member is connected to the first side of the supporting platform. The second direction and the first direction are located in the same plane and are perpendicular to the first direction. The adjusting member moves along the second direction to drive the supporting platform to rotate.

4. The chip sequencer according to claim 3, wherein The rotation adjustment assembly further includes an elastic member, which abuts against a second side surface of the supporting platform, where the second side surface is a surface facing away from the first side surface, and the elastic member is used to eliminate a reverse clearance during rotation of the supporting platform.

5. The chip sequencer according to claim 4, wherein The adjusting member and the elastic member are arranged opposite to each other.

6. The chip sequencer according to claim 2, wherein The rotation adjustment assembly further includes a mounting member, wherein the mounting member is disposed on the moving platform, and the adjustment member is disposed on the mounting member.

7. The chip sequencer according to claim 2, wherein The rotation adjustment assembly further includes a locking member, which is used to lock and fix the supporting platform to the fixing platform.

8. The chip sequencer according to claim 2, wherein The supporting platform is rotatably connected to the moving platform via a rotating shaft, and the adjusting member is used to adjust the supporting platform to rotate around the rotating shaft.

9. The chip sequencer according to claim 4, wherein The movable platform is provided with a first bearing platform and a second bearing platform. The first bearing platform and the second bearing platform are respectively provided with an adjusting member, and the first bearing platform and the second bearing platform correspond to the same elastic member.

10. The chip sequencer according to claim 9, wherein The elastic member is squeezed between the first bearing platform and the second bearing platform, one end of the elastic member is connected to the first bearing platform, and the other end of the elastic member is connected to the second bearing platform.

11. A chip motion platform, characterized in that: include: Fixed table; a movable platform, the movable platform being movable along a first direction and being disposed on the fixed platform; A carrier platform, which is disposed on the mobile platform and is used to fix the carrier chip; a moving drive member connected to the moving platform and configured to drive the moving platform and the carrying platform to move along the first direction; as well as A rotation adjustment component is connected to the carrier platform, and is used to adjust the carrier platform to rotate relative to the movable platform to adjust the length direction of the flow channel of the chip on the carrier platform to be parallel to the first direction.

12. The chip motion platform according to claim 11, wherein: The movable platform is provided with a first supporting platform and a second supporting platform, the rotation adjustment assembly includes an adjusting member and an elastic member, the first supporting platform and the second supporting platform are respectively provided with an adjusting member, and the first supporting platform and the second supporting platform correspond to the same elastic member.