Implantable stent device for treating nasosinusitis

Abstract

The invention relates to an implantable stent device for treating nasosinusitis, the implantable stent device for treating nasosinusitis comprises a plurality of elastic rods, the elastic rods are made of biodegradable polymers, the plurality of elastic rods are annularly and crossly distributed to form a stent of a tubular net structure, and the elastic rods are made of biodegradable polymers. The implantable stent device comprises an elastic rod, the outer surface of the elastic rod is provided with a plurality of containing holes, the containing holes are filled with anti-inflammatory slow-release drugs, the outer surface of the elastic rod is further coated with a bacteriostatic agent coating, and the implantable stent device is formed by annularly and crossly distributing the multiple elastic rods supported by biodegradable polymers and has a mechanical supporting function; the containing holes formed in the elastic rods are filled with the anti-inflammatory slow-release medicine, the medicine can be continuously administrated to the affected part of the patient, and an innovative scheme is provided for non-surgical treatment of nasosinusitis and nasal polyp.

Description

Technical Field

[0001] The present invention belongs to the technical field of sinusitis treatment, and in particular relates to an implantable stent device for treating sinusitis. Background Art

[0002] Sinusitis is a common condition defined as symptomatic inflammation of the paranasal sinuses lasting longer than twelve weeks, affecting up to 16% of the population. The cavities involved in sinusitis include the maxillary, frontal, ethmoid, ostiomeatal complex, ethmoidal and sphenoid sinuses, as well as the middle meatus, or a combination thereof. Common symptoms of sinusitis include nasal obstruction, a feeling of pressure or fullness, runny nose, and loss of smell; these symptoms may be due to mucosal inflammation, local infection, or impaired mucociliary function.

[0003] The current method generally uses drugs to control infection and relieve symptoms. Severe cases require surgical treatment. Drug control takes a long time to act on the lesions and the effect is poor. Although surgical treatment can quickly relieve symptoms, patients need to endure greater pain and the recovery time is slow. Summary of the Invention

[0004] The purpose of the present invention is to provide an implantable stent device for treating sinusitis with a simple structure and reasonable design in order to solve the above problems.

[0005] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0006] A stent device for treating sinusitis includes a plurality of elastic rods made of a biodegradable polymer. The plurality of elastic rods are arranged in a circular cross-distribution to form a tubular network structure stent. The outer surfaces of the elastic rods are provided with a plurality of receiving holes filled with anti-inflammatory sustained-release drugs. The outer surfaces of the elastic rods are also coated with an antibacterial coating. The tubular network structure stent is implanted into the patient's sinuses through a minimally invasive implantation method.

[0007] As a further optimization solution of the present invention, the tubular mesh structure stent has a conical or cylindrical shape, adapted to the anatomical structure of the ethmoid sinus, maxillary sinus or frontal sinus, and has an axial length of 10-25 mm.

[0008] As a further optimization solution of the present invention, both ends of the tubular network structure stent are fixedly connected with a support ring made of biodegradable polymer, and a plurality of anchoring fins are annularly distributed on the outer wall of the support ring.

[0009] As a further optimized solution of the present invention, the biodegradable polymer is selected from polylactic acid, polyglycolic acid or copolymers thereof, and the complete degradation time of the biodegradable polymer is 3-6 months.

[0010] As a further optimization solution of the present invention, the diameter of the accommodating hole opened on the elastic rod is 0.5-1 mm, and the porosity is 60 ≥%.

[0011] As a further optimized solution of the present invention, the anti-inflammatory sustained-release drug is a glucocorticoid drug, and the sustained release time of the drug is 3-6 months.

[0012] As a further optimized solution of the present invention, the antibacterial coating contains gentamicin or chitosan derivatives, and the drug loading amount is 0.5-2% of the total mass of the stent.

[0013] As a further optimization solution of the present invention, the elastic rod is provided with a through hole along its length direction, and sealing portions for sealing the ends of the through hole are integrally formed at both ends of the elastic rod, and the through hole is filled with air.

[0014] The beneficial effects of the present invention are:

[0015] 1. This implantable stent device is formed by a circular cross-distribution of multiple elastic rods supported by a biodegradable polymer. It has a mechanical support function and can keep the patient's sinus ostium unobstructed. The receiving holes set on the elastic rods are filled with anti-inflammatory sustained-release drugs, which can continuously deliver the drug to the patient's affected area, providing an innovative solution for non-surgical treatment of sinusitis and nasal polyps.

[0016] 2. Support rings made of biodegradable polymers are fixedly connected at both ends of the tubular network structure stent formed by the circular cross distribution of multiple elastic rods. Multiple anchoring wings are distributed in a ring on the outer wall of the support ring. After the stent is implanted, the tubular network structure stent can be fixed in the folds in the patient's sinuses through the support ring and the anchoring wings to prevent the tubular network structure stent from being displaced when subjected to force, which affects the treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0018] Figure 2 This invention Figure 1 Schematic diagram of the cross-section structure;

[0019] Figure 3 This is a schematic diagram of the positions of the through holes of the present invention;

[0020] Figure 4 This is a schematic diagram of the structure of the elastic rod end portion of the present invention;

[0021] Figure 5 This invention Figure 3 Schematic diagram of the cross-section structure.

[0022] In the figure: 1. elastic rod; 2. support ring; 3. anchoring wing; 4. through hole; 5. sealing part; 6. receiving hole; 7. anti-inflammatory sustained-release drug; 8. antibacterial coating. DETAILED DESCRIPTION

[0023] The present application is described in further detail below in conjunction with the accompanying drawings. It is necessary to point out that the following specific implementation methods are only used to further illustrate the present application and cannot be understood as limiting the scope of protection of the present application. Technicians in this field can make some non-essential improvements and adjustments to the present application based on the above application content.

[0024] Example

[0025] like Figure 1 - Figure 5 As shown, an implantable stent device for treating sinusitis includes a plurality of elastic rods 1. The elastic rods 1 are made of a biodegradable polymer selected from polylactic acid, polyglycolic acid, or copolymers thereof. The biodegradable polymer has a complete degradation time of 3-6 months. This allows the elastic rods 1 to automatically degrade 3-6 months after implantation in the human body, eliminating the need for removal. This is not only convenient to use, but also reduces pain for the user when removing the stent device.

[0026] Multiple elastic rods 1 are arranged in a circular cross-shaped pattern to form a tubular mesh structure stent. The tubular mesh structure stent has a conical or cylindrical shape, adapted to the anatomical structure of the ethmoid sinus, maxillary sinus or frontal sinus, and has an axial length of 10-25 mm. When the tubular mesh structure stent is implanted into the patient's sinus, it can support the patient's polyps through the tubular mesh structure stent, minimizing the obstruction of the respiratory tract by the polyps in the inflamed area, allowing the patient to breathe more smoothly.

[0027] To prevent the tubular mesh structure stent from shifting due to force when implanted in the patient's sinuses, support rings 2 made of biodegradable polymer are fixedly connected to both ends of the tubular mesh structure stent. Multiple anchoring fins 3 are distributed in an annular pattern on the outer wall of the support ring 2. After the tubular mesh structure stent is implanted in the patient's sinuses, the support rings 2 and the anchoring fins 3 can be used to fix the tubular mesh structure stent in the folds of the patient's sinuses.

[0028] The outer surface of the elastic rod 1 is provided with a plurality of receiving holes 6, each having a diameter of 0.5-1 mm and a porosity of ≥60%. The receiving holes 6 are filled with an anti-inflammatory sustained-release drug 7. As the elastic rod 1 degrades, the anti-inflammatory sustained-release drug 7 filled in the receiving holes 6 can be discharged from the receiving holes 6 and act on the affected sinus of the patient, continuously administering the drug to the affected area, reducing inflammation in the inflamed sinus of the patient, and gradually recovering under the action of the drug.

[0029] The anti-inflammatory sustained-release drug 7 is a glucocorticoid drug with good bactericidal and disinfecting effects. The drug is continuously released for 3-6 months. When the elastic rod 1 is completely degraded, the drug filled in the receiving hole 6 is also completely consumed.

[0030] Because the patient's sinuses may be damaged when the tubular mesh structure stent is implanted, the outer surface of the elastic rod 1 is also coated with an antibacterial coating 8. The antibacterial coating 8 contains gentamicin or a chitosan derivative, and the drug loading amount is 0.5-2% of the total mass of the stent. The antibacterial coating 8 can be quickly decomposed after implantation, acting on the damaged area of ​​the patient caused by the implantation of the tubular mesh structure stent, inhibiting the growth of bacteria in the damaged area and promoting rapid recovery of the damaged area.

[0031] The elastic rod 1 is provided with a through hole 4 along its length, and a sealing portion 5 is integrally formed at both ends of the elastic rod 1 for sealing the end of the through hole 4. The through hole 4 is filled with air, and the air is sealed in the through hole 4. When the elastic rod 1 is subjected to an external force, it can be buffered by air compression. When the external force disappears, the elastic rod 1 can be pushed back to its original position by the air, thereby ensuring the support function of the tubular network structure bracket formed by the combination of the elastic rods 1;

[0032] The tubular mesh structure stent is implanted into the patient's sinuses through a minimally invasive implantation method. The implantation process only requires local anesthesia and is completed with a nasal endoscope. The operation is simple, the wound is small, and the patient recovers quickly, thus avoiding the problem of existing surgical treatment options that patients need to endure greater pain and slow recovery time.

[0033] It should be noted that, in this implantable stent device for treating sinusitis, after locating the position of the lesion sinus opening through nasal endoscope, the tubular mesh structure stent formed by the cross-distribution of elastic rods 1 is compressed and pushed to the target position. After loosening the tubular mesh structure stent, the tubular mesh structure stent is unfolded under the action of its own elastic force, so that the support rings 2 set at both ends cooperate with the anchoring wings 3 to fix the tubular mesh structure stent in the folds in the patient's sinus, support the patient's polyps, try to avoid the polyps in the inflamed position from blocking the respiratory tract, and make the patient breathe more smoothly. The surface of the elastic rod 1 is coated with an antibacterial coating 8. After implantation The antibacterial coating 8 can be quickly released and directly reach the damaged position in the patient's sinus caused by the implanted tubular mesh structure stent, inhibiting the growth of bacteria in the damaged position and ensuring rapid recovery of the damaged position. At the same time, it can also provide preliminary treatment for the inflamed position of the patient's sinus. The receiving hole 6 opened on the elastic rod 1 is filled with anti-inflammatory sustained-release drug 7. Since the elastic rod 1 is made of a biodegradable polymer, as the elastic rod 1 degrades, the anti-inflammatory sustained-release drug 7 filled in the receiving hole 6 can be discharged from the receiving hole 6 and act on the affected part of the patient's sinus. The drug is continuously administered to the affected part of the patient, and the drug can directly reach the lesion, greatly improving the treatment efficiency.

[0034] The above-described embodiments merely illustrate several implementations of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the spirit of the present invention, and all such variations and improvements fall within the scope of protection of the present invention.

Claims

1. A stent device for treating sinusitis, comprising a plurality of elastic rods (1), characterized in that: The elastic rod (1) is made of a biodegradable polymer, and a plurality of the elastic rods (1) are cross-distributed in a circular manner to form a tubular network structure stent. The outer surface of the elastic rod (1) is provided with a plurality of receiving holes (6), and the receiving holes (6) are filled with an anti-inflammatory sustained-release drug (7). The outer surface of the elastic rod (1) is also coated with an antibacterial coating (8), and the tubular network structure stent is implanted into the patient's sinus through a minimally invasive implantation method.

2. The implantable stent device for treating sinusitis according to claim 1, characterized in that: The tubular mesh structure stent has a conical or cylindrical shape, adapted to the anatomical structure of the ethmoid sinus, maxillary sinus or frontal sinus, and has an axial length of 10-25 mm.

3. The implantable stent device for treating sinusitis according to claim 1, characterized in that: Both ends of the tubular network structure support are fixedly connected to a support ring (2) made of a biodegradable polymer, and a plurality of anchoring fins (3) are annularly distributed on the outer wall of the support ring (2).

4. The implantable stent device for treating sinusitis according to claim 3, characterized in that: The biodegradable polymer is selected from polylactic acid, polyglycolic acid or copolymers thereof, and the complete degradation time of the biodegradable polymer is 3-6 months.

5. The implantable stent device for treating sinusitis according to claim 1, characterized in that: The accommodating hole (6) provided on the elastic rod (1) has a diameter of 0.5-1 mm and a porosity of ≥60%.

6. The implantable stent device for treating sinusitis according to claim 1, characterized in that: The anti-inflammatory sustained-release drug (7) is a glucocorticoid drug, and the sustained release time of the drug is 3-6 months.

7. The implantable stent device for treating sinusitis according to claim 1, characterized in that: The antibacterial coating (8) contains gentamicin or chitosan derivatives, and the drug loading amount is 0.5-2% of the total mass of the stent.

8. The implantable stent device for treating sinusitis according to claim 1, characterized in that: The elastic rod (1) is provided with a through hole (4) along its length direction, and sealing portions (5) for sealing the ends of the through hole (4) are integrally formed at both ends of the elastic rod (1), and the through hole (4) is filled with air.

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