Water-in-oil high-efficiency sunscreen cream, preparation method and application thereof

Abstract

The present application relates to a kind of water-in-oil high-efficiency sunscreen cream and its preparation method and application, belong to daily chemical technical field.The water-in-oil high-efficiency sunscreen cream described in the present application includes 10-35% sunscreen agent, 2-8% film-forming synergist, 15-40% oil, 3-10% polyhydric alcohol, 0.1-4% plant extract, 2-8% emulsifier, 1-7% film-forming agent, 0-5% auxiliary material and the balance water;Film-forming synergist, the film-forming synergist includes isododecane, oxypentanedioic acid, lithium montmorillonite of distearyldimethylammonium, trimethylsilyl oxysilicate, sodium hyaluronate cross-linked polymer.The sunscreen cream described in the present application has good sunscreen effect.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of water-in-oil high efficiency sunscreen cream and its preparation method and application, belong to daily chemical technical field. BACKGROUND

[0002] With the deepening of the harm of ultraviolet radiation (UVR) to human skin (such as photoaging, DNA damage, and increased risk of skin cancer), sunscreen cosmetics have become a global demand. Traditional sunscreens are divided by mechanism: chemical sunscreens (such as avobenzone, octocrylene): through benzene ring conjugated structure absorption UV, but there is poor light stability (such as avobenzone 2h light degradation 40%), sensitization risk; Physical sunscreen (such as nano titanium dioxide, zinc oxide): reflect / scatter ultraviolet light, high safety, but high addition amount is easy to whiten, skin feel heavy.

[0003] The type of sunscreen product can be divided into oil-in-water (O / W) or water-in-oil (W / O) system; Among them, O / W system skin feel is refreshing, and water resistance and durability are insufficient; Two W / O system has excellent water and sweat resistance, and higher sunscreen durability.

[0004] The sunscreen cosmetics of water-in-oil system in the market at present have single function or uneven function strength. Therefore, it is a technical problem to be solved to provide a water-in-oil sunscreen cream with excellent multifunctional strength and good sunscreen effect. SUMMARY

[0005] In view of the above technical problems, the present application provides a kind of water-in-oil high efficiency sunscreen cream and its preparation method and application, belong to daily chemical technical field.

[0006] On the one hand, the present application provides a kind of water-in-oil high efficiency sunscreen cream, raw material includes film forming synergist, the film forming synergist includes isododecane, oxypentanedioic acid, lithium montmorillonite of distearyldimethylammonium, trimethylsilyloxy silicate, sodium hyaluronate cross-linked polymer.

[0007] Preferably, the amount of film forming synergist in the water-in-oil high efficiency sunscreen cream is 2-8wt%.

[0008] Preferably, the weight percentage content of film forming synergist in sunscreen emulsion product is respectively: 1.5-3% isododecane, 0.000001-0.2% oxypentanedioic acid, 0.3-1.5% lithium montmorillonite of distearyldimethylammonium, 0.2-1.2% trimethylsilyloxy silicate, 0.001-0.8% sodium hyaluronate cross-linked polymer.

[0009] Preferably, the weight percentage content of the film-forming synergist in the sunscreen emulsion product is respectively: 1.8% isododecane, 0.0000045% oxoglutaric acid, 0.45% lithium montmorillonite dimethyl ammonium, 0.36% trimethylsiloxy silicate, 0.0054% sodium hyaluronate cross-linked polymer.

[0010] Preferably, the raw materials in the water-in-oil high-efficiency sunscreen cream according to the weight percentage further include 10-35% sunscreen agent, 2-8% film-forming synergist, 15-40% oil, 3-10% polyhydric alcohol, 0.1-4% plant extract, 2-8% emulsifier, 1-7% film-forming agent, 0-5% auxiliary material, and the balance water.

[0011] Preferably, the raw materials in the water-in-oil high-efficiency sunscreen cream according to the weight percentage further include 10-25% sunscreen agent, 2-8% film-forming synergist, 15-40% oil, 3-10% polyhydric alcohol, 0.1-4% plant extract, 2-8% emulsifier, 1-3% film-forming agent, 0-1.5% auxiliary material, and the balance water.

[0012] Preferably, the oil in the water-in-oil high-efficiency sunscreen cream includes at least one of synthetic oil, vegetable oil, or animal oil.

[0013] Preferably, the sunscreen agent in the water-in-oil high-efficiency sunscreen cream includes at least one of physical sunscreen agent and chemical sunscreen agent.

[0014] Preferably, the polyhydric alcohol in the water-in-oil high-efficiency sunscreen cream includes at least one of ethylene glycol, propylene glycol, glycerol, hexylene glycol, sorbitol, and polyethylene glycol.

[0015] Preferably, the auxiliary material in the water-in-oil high-efficiency sunscreen cream includes at least one of preservative, chelating agent, essence, and pH regulator. In addition, the auxiliary material can also select conventional auxiliary material ingredients in cosmetics according to functional requirements.

[0016] The application further provides a preparation method of the water-in-oil high-efficiency sunscreen cream, characterized in that the method includes the following steps: (1) heating the oil and the sunscreen agent, adding the emulsifier, the film-forming agent, and the film-forming synergist, stirring to obtain an oil phase; (2) heating the water, adding the polyhydric alcohol and the auxiliary material, stirring to obtain an aqueous phase; (3) adding the aqueous phase to the oil phase, shearing and emulsifying, then cooling to 35-50°C, adding the plant extract, continuing to shear and emulsify, aging, sterilizing, and filling to obtain the water-in-oil high-efficiency sunscreen cream.

[0017] Preferably, in the preparation method, the heating in step (1) is to 60-85°C. The heating in step (2) is to 60-85°C. The cooling in step (3) is to 35-50°C.

[0018] In another aspect, the present application also provides a sunscreen cream, which comprises: dimethicone, titanium dioxide (nano), PEG-9 dimethicone crosspolymer, hydrous silicic acid, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, hydrogenated polydimethylsiloxane, aluminum hydroxide, CI 77492, triethoxysilane, CI 77491, isododecane, disteardimonium hectorite, trimethylsiloxysilicate, water, 1,2-hexanediol, phenoxyethanol, oxoglutaric acid, disteardimonium hectorite, triethyl citrate, zinc oxide (nano), hydrogenated polydimethylsiloxane, aluminum hydroxide, trimethylsiloxysilicate, phenylbenzimidazole sulfonic acid, aminomethyl propanol, sodium chloride, dipotassium glycyrrhizate, disodium EDTA, butylene glycol, squalane, sodium hyaluronate (1.2 million molecular weight), sodium hyaluronate (200,000 molecular weight), sodium hyaluronate (2.1 million molecular weight), glycerin, glycereth-26, sodium hyaluronate crosspolymer, methoxyethyl salicylate, butylated hydroxytoluene, ethylhexyl salicylate, dibutyl adipate, diethylhexyl aminobenzoic acid hexyl benzoate, octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, methacrylate crosspolymer, dimethyl methicone, trimethylsiloxysilicate, silica, methicone, phenyltrimethylsiloxysilicate, cetyl PEG / PPG-10 / 1 dimethicone, vinyl dimethicone / methicone silsesquioxane crosspolymer, PEG-9 dimethicone crosspolymer, acrylates / dimethicone copolymer, ascorbyl tetraisopalmitate, tocopheryl acetate, niacinamide, tranexamic acid, aloe barbadensis leaf juice, trehalose, ethylhexylglycerin, bisabalol, zingiber officinale root extract, fragrance, hydroxypropyl cyclodextrin, glabriden, polyquaternium-51, glycerin, camellia sinensis leaf extract, sodium pyrosulfite, p-methoxyacetophenone, scutellaria baicalensis root extract, p-methoxyacetophenone, ligusticum chuanxiong rhizome extract.

[0019] The present application also provides the use of the water-in-oil high-efficiency sunscreen cream in the preparation of a skin preparation, and the amount of the water-in-oil high-efficiency sunscreen cream in the skin preparation is 1-50 wt%.

[0020] The beneficial effects of the present application compared to the prior art are as follows:

[0021] The water-in-oil high-efficiency sunscreen cream comprises 10-35% sunscreen agent, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.1-4% plant extract, 2-8% emulsifier, 1-7% film-forming agent, 0-5% auxiliary material and the balance of water; the film-forming synergist comprises isododecane, oxoglutaric acid, lithium montmorillonite dimethylammonium distearate, trimethylsiloxy silicate and sodium hyaluronate cross-linked polymer. The sunscreen cream prepared by the method has good sunscreen effect and good application prospect.

[0022] In addition, the sunscreen cream has small change in emulsion particle size after being stored at room temperature for 60 days, and has small change in particle size when being stored in high-temperature and low-temperature environments, and has high stability.

[0023] The use of the colophony PEG / PPG-10 / 1 dimethyl polysiloxane, polyglyceryl-2 diisostearate / IPDI copolymer and PEG-8 glyceryl isostearate collocation system can excellently stabilize the emulsion performance. In the emulsifier system selected by the application, the colophony PEG / PPG-10 / 1 dimethyl polysiloxane and polyglyceryl-2 diisostearate / IPDI copolymer have a synergistic effect on stabilizing the emulsion, and can give the emulsion system better stability.

[0024] Furthermore, the sunscreen cream obtained by the application can inhibit the release of TNF-α and IL-6, inhibit inflammation and has good anti-inflammatory performance, and can reduce the occurrence of acne or skin inflammation.

[0025] The use of the horseradish extract and the lilium lancifolium extract can significantly improve the anti-inflammatory performance of the sunscreen cream. The horseradish extract and the lilium lancifolium extract in the application have a synergistic effect on inhibiting inflammation. The effect is better when the weight ratio of the horseradish extract to the lilium lancifolium extract is in the range of 1:0.5-1.5.

[0026] The sunscreen cream prepared by the application has excellent sunscreen effect, and the SPF value is above 48.

[0027] The sunscreen cream has excellent performance effect, simple process and good application prospect. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 : TNF-α and IL-6 levels of the sunscreen cream

[0029] Figure 2 : SPF value of the sunscreen cream DETAILED DESCRIPTION

[0030] The application will be further described in detail below in combination with specific embodiments.

[0031] The application provides a water-in-oil high-efficiency sunscreen cream, raw materials of which include film-forming synergist, the film-forming synergist includes isododecane, oxoglutaric acid, lithium montmorillonite dimethyl stearate, trimethyl siloxy silicate and sodium hyaluronate cross-linked polymer.

[0032] Preferably, the film-forming synergist in the water-in-oil high-efficiency sunscreen cream accounts for 2-8 wt%.

[0033] Preferably, the film-forming synergist in the sunscreen cream product accounts for 1.5-3 wt% isododecane, 0.000001-0.2 wt% oxoglutaric acid, 0.3-1.5 wt% lithium montmorillonite dimethyl stearate, 0.2-1.2 wt% trimethyl siloxy silicate and 0.001-0.8 wt% sodium hyaluronate cross-linked polymer.

[0034] Preferably, the film-forming synergist in the sunscreen cream product accounts for 1.8 wt% isododecane, 0.3 wt% butylene glycol, 0.45 wt% lithium montmorillonite dimethyl stearate, 0.36 wt% trimethyl siloxy silicate and 0.054 wt% sodium hyaluronate cross-linked polymer.

[0035] Preferably, the water-in-oil high-efficiency sunscreen cream further includes 10-35 wt% sunscreen agent, 2-8 wt% film-forming synergist, 15-40 wt% oil, 3-10 wt% polyol, 0.1-4 wt% plant extract, 2-8 wt% emulsifier, 1-7 wt% film-forming agent, 0-5 wt% auxiliary material and the rest water.

[0036] Preferably, the water-in-oil high-efficiency sunscreen cream further includes 10-25 wt% sunscreen agent, 2-8 wt% film-forming synergist, 15-40 wt% oil, 3-10 wt% polyol, 0.1-4 wt% plant extract, 2-8 wt% emulsifier, 1-3 wt% film-forming agent, 0-1.5 wt% auxiliary material and the rest water.

[0037] Preferably, the oil in the water-in-oil high-efficiency sunscreen cream includes at least one of synthetic oil, plant oil or animal oil.

[0038] Preferably, the oil in the water-in-oil high-efficiency sunscreen cream includes at least one of squalane, jojoba oil, sweet almond oil, macadamia nut oil, caprylic / capric triglyceride, isopropyl myristate, dimethicone and shea butter.

[0039] Preferably, the sunscreen agent in the water-in-oil high-efficiency sunscreen cream includes at least one of physical sunscreen agent and chemical sunscreen agent.

[0040] Preferably, the sunscreen agent in the water-in-oil high-efficiency sunscreen cream includes at least one of ethylhexyl methoxy cinnamate, octocrylene, ethylhexyl salicylate, terephthalylidene dicamphor sulfonic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, phenylbenzimidazole sulfonic acid, homosalate.

[0041] Preferably, the sunscreen agent in the water-in-oil high-efficiency sunscreen cream includes 3-6% ethylhexyl methoxy cinnamate, 3-6% octocrylene, 1-3.5% ethylhexyl salicylate, 0.5-2.5% phenylbenzimidazole sulfonic acid, 2.5-7% homosalate.

[0042] Preferably, the polyol in the water-in-oil high-efficiency sunscreen cream includes at least one of ethylene glycol, propylene glycol, glycerin, hexylene glycol, sorbitol, and polyethylene glycol.

[0043] Preferably, the auxiliary material in the water-in-oil high-efficiency sunscreen cream includes at least one of preservatives, chelating agents, fragrances, and pH regulators. In addition, the auxiliary material can also select conventional auxiliary material ingredients in cosmetics according to functional requirements.

[0044] Preferably, the auxiliary material in the water-in-oil high-efficiency sunscreen cream includes 0-0.4% phenoxyethanol, 0-0.4% disodium EDTA, and 0-0.7% citric acid.

[0045] Preferably, the plant extract in the water-in-oil high-efficiency sunscreen cream includes at least one of tea extract, horseradish extract, aloe barbadensis miller extract, and magnolia denudata extract.

[0046] Preferably, the plant extract in the water-in-oil high-efficiency sunscreen cream can also be 0.5-4%, including: 0.05-0.5% tea extract, 0.2-1.5% horseradish extract, 0.05-0.5% aloe barbadensis miller extract, and 0.2-1.5% magnolia denudata extract.

[0047] Preferably, the weight ratio of the horseradish extract and the magnolia denudata extract in the water-in-oil high-efficiency sunscreen cream is 1:0.5-1.5.

[0048] Preferably, the emulsifier in the water-in-oil high-efficiency sunscreen cream includes at least one of cetyl PEG / PPG-10 / 1 dimethicone, polyglyceryl-2 diisostearate / IPDI copolymer, and PEG-8 glyceryl isostearate.

[0049] Preferably, the amount of emulsifier in the water-in-oil high-efficiency sunscreen cream is 3.5-8%, including 1.5-3.2% cetyl PEG / PPG-10 / 1 dimethicone, 1.5-3.2% polyglyceryl-2 diisostearate / IPDI copolymer, and 0.5-1.6% PEG-8 glyceryl isostearate.

[0050] Preferably, the film-forming agent in the water-in-oil high-efficiency sunscreen cream includes at least one of acrylate copolymer, VP / hexadecene copolymer, polyvinylpyrrolidone, vinyl dimethicone / methicone silsesquioxane crosspolymer, styrene / acrylate copolymer, and polysilicone-11.

[0051] Preferably, the water-in-oil high-efficiency sunscreen cream includes, by weight percentage, 10-35% sunscreen agent, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.5-4% plant extract, 3.5-8% emulsifier, 1-7% film-forming agent, 0-5% auxiliary material, and the balance water; the plant extract includes 0.05-0.5% tea leaf extract, 0.2-1.5% horseradish extract, 0.05-0.5% aloe barbadensis leaf extract, and 0.2-1.5% lilium tigerinum extract; the emulsifier includes 1.5-3.2% cetyl PEG / PPG-10 / 1 dimethicone, 1.5-3.2% polyglyceryl-2 diisostearate / IPDI copolymer, and 0.5-1.6% PEG-8 glyceryl isostearate.

[0052] Preferably, the water-in-oil high-efficiency sunscreen cream includes, by weight percentage, 10-25% sunscreen agent, 2-8% film-forming synergist, 15-40% oil, 3-10% polyol, 0.5-4% plant extract, 3.5-8% emulsifier, 1-3% film-forming agent, 0-1.5% auxiliary material, and the balance water; the plant extract includes 0.05-0.5% tea leaf extract, 0.2-1.5% horseradish extract, 0.05-0.5% aloe barbadensis leaf extract, and 0.2-1.5% lilium tigerinum extract; the emulsifier includes 1.5-3.2% cetyl PEG / PPG-10 / 1 dimethicone, 1.5-3.2% polyglyceryl-2 diisostearate / IPDI copolymer, and 0.5-1.6% PEG-8 glyceryl isostearate.

[0053] The application further provides a preparation method of the water-in-oil high-efficiency sunscreen cream, characterized by comprising the following steps: (1) heating oil and sunscreen, adding emulsifier, film forming agent and film forming synergist, stirring to obtain an oil phase; (2) heating water, adding polyol and auxiliary materials, stirring to obtain an aqueous phase; (3) adding the aqueous phase into the oil phase, shearing and emulsifying, then cooling, adding plant extract, continuing shearing and emulsifying, aging, sterilizing, filling to obtain the water-in-oil high-efficiency sunscreen cream.

[0054] Preferably, in the preparation method, heating to 60-85℃ in step (1). Heating to 60-85℃ in step (2). Cooling to 35-50℃ in step (3).

[0055] The application further provides application of the water-in-oil high-efficiency sunscreen cream in preparation of skin preparations, wherein the water-in-oil high-efficiency sunscreen cream is used in an amount of 1-50wt% in the skin preparations.

[0056] The raw material information in the following specific examples is as follows:

[0057] Lithium montmorillonite disteridimethylammonium: Zhejiang Huate New Material Co., Ltd.; Sodium hyaluronate cross-linked polymer: Wuhan Kemik Biomedical Technology Co., Ltd.; Squalane: Jinan Zhiheng Chihuang Chemical Technology Co., Ltd.; Jojoba oil: Hunan Honghua Jinjia Ecological Environment Engineering Co., Ltd.; Sweet almond oil: Jining Fangyu Chemical Co., Ltd.; Caprylic / capric triglyceride: Wuhan Smek Biotechnology Co., Ltd.; Dimethicone: Wuhan Linsheng Technology Co., Ltd.; Avocado fruit fat: Hubei Xinghengye Technology Co., Ltd.

[0058] Tea extract: green tea powder is crushed, then 35wt% ethanol is added according to the solid-liquid weight ratio of 1:20, stirring extraction is carried out at 50℃ and 60rpm for 3 hours, the filtrate is concentrated under reduced pressure at 55℃, and then the concentrate is freeze-dried at-50℃ to contain 1.90wt% of water, and the tea extract is obtained.

[0059] Horseradish extract: dry horseradish roots are crushed, then 25wt% ethanol is added according to the solid-liquid ratio of 1:25g / mL, and then the mixture is heated to 52℃ and stirred at 80rpm for 4 hours, then filtration is carried out, the filtrate is concentrated under reduced pressure at 55℃, and then the concentrate is freeze-dried at-55℃ to contain 2.34wt% of water, and the horseradish extract is obtained.

[0060] Aloe vera extract: aloe vera leaves are taken, the skin is removed, the pulp is mixed with water according to the weight ratio of 1:20, heated to 45℃ and stirred at 60rpm for 2 hours, then filtration is carried out, and the filtrate is freeze-dried to obtain the aloe vera extract.

[0061] Cymbidium goeringii extract; dry Cymbidium goeringii bulb, crush, then mix with 40wt% ethanol according to the ratio of 1:20g / mL, heat to 45℃, stir at 100rpm for 5 hours, then filter, filtrate is concentrated under reduced pressure at 55℃, then the concentrate is freeze-dried at -45℃ to 2.44wt% water content, then it is obtained.

[0062] I. Example 1

[0063] Sunscreen cream 1

[0064] Raw material composition, weight percentage: 2.7000045% film-forming synergist, 20% sunscreen, 25% oil, 8% polyol, 2.3% plant extract, 5.5% emulsifier, 3% film-forming agent, 1% auxiliary material and the balance water;

[0065] Film-forming synergist: 1.8% isododecane, 0.0000045% oxoglutaric acid, 0.45% lithium montmorillonite dimethylammonium stearate, 0.36% trimethylsiloxy silicate, 0.09% sodium hyaluronate cross-linked polymer;

[0066] Sunscreen: 4% ethylhexyl methoxy cinnamate, 5% octocrylene, 3% ethylhexyl salicylate, 2% phenyl benzimidazole sulfonic acid, 6% homosalate;

[0067] Oil: 3% squalane, 6% jojoba oil, 5% sweet almond oil, 5% caprylic / capric triglyceride, 3% dimethicone, 3% shea butter;

[0068] Polyol: 3% ethylene glycol, 4% 1,2-propanediol, 1% glycerol;

[0069] Plant extract: 0.2% tea extract, 1.2% horseradish extract, 0.3% aloe barbadensis extract, 0.6% Cymbidium goeringii extract;

[0070] Emulsifier: 2.3% cetyl PEG / PPG-10 / 1 dimethicone, 2.2% polyglyceryl-2 diisostearate / IPDI copolymer and 1% PEG-8 glyceryl isostearate;

[0071] Film-forming agent: 1.5% VP / hexadecene copolymer, 1.5% styrene / acrylic acid copolymer;

[0072] Auxiliary material: 0.3% phenoxyethanol, 0.3% disodium EDTA and 0.4% citric acid.

[0073] Preparation method: (1) add oil raw material and sunscreen raw material to the container, heat to 82℃, stir at 80rpm for 10 minutes, then add emulsifier raw material, film-forming agent raw material and film-forming synergist raw material, continue to stir at 120rpm for 20 minutes, to obtain oil phase;

[0074] (2) heating water to 75℃, adding polyol raw materials and auxiliary raw materials, stirring at 100 rpm for 20 minutes to obtain an aqueous phase;

[0075] (3) adding the aqueous phase to the oil phase, shearing and emulsifying at 700 rpm for 40 minutes, then cooling to 40℃, adding plant extracts, maintaining the speed and continuing to shear and emulsify for 10 minutes, standing at room temperature for 30 minutes, sterilizing, filling, to obtain the water-in-oil sunscreen emulsion.

[0076] Sunscreen emulsion 2

[0077] Raw material composition, weight percentage: 3.0002% film-forming synergist, 20.3% sunscreen, 24% oil, 8.5% polyol, 2.32% plant extract, 5.45% emulsifier, 2.8% film-forming agent, 1.1% auxiliary material and the balance water;

[0078] Film-forming synergist: 2% isododecane, 0.0002% oxovaleric acid, 0.4% lithium montmorillonite dimethylammonium distearate, 0.5% trimethylsiloxy silicate, 0.1% sodium hyaluronate cross-linked polymer;

[0079] Sunscreen: 5% ethylhexyl methoxy cinnamate, 4.5% octocrylene, 3.5% ethylhexyl salicylate, 2.5% phenyl benzimidazole sulfonic acid, 4.8% homosalate;

[0080] Oil: 5% squalane, 3% jojoba oil, 7% sweet almond oil, 2% caprylic / capric triglyceride, 2.5% dimethicone, 4.5% shea butter;

[0081] Polyol: 2% ethylene glycol, 6% 1,2-propanediol, 0.5% glycerol;

[0082] Plant extract: 0.25% tea extract, 0.72% horseradish extract, 0.27% aloe barbadensis extract, 1.08% ranunculus extract;

[0083] Emulsifier: 1.5% cetyl PEG / PPG-10 / 1 dimethicone, 3% polyglyceryl-2 diisostearate / IPDI copolymer and 0.95% PEG-8 glyceryl isostearate;

[0084] Film-forming agent: 1.2% VP / hexadecene copolymer, 1.6% styrene / acrylic acid (ester) copolymer;

[0085] Auxiliary material: 0.35% phenoxyethanol, 0.35% disodium EDTA and 0.4% citric acid.

[0086] Preparation method: (1) add oil and sunscreen raw materials into a container, heat to 80℃, stir at 100 rpm for 12 minutes, then add emulsifier raw materials, film forming agent raw materials and film forming synergist raw materials, continue to stir at 130 rpm for 25 minutes to obtain an oil phase;

[0087] (2) heat water to 75℃, add polyol raw materials and auxiliary raw materials, stir at a speed of 120 rpm for 25 minutes to obtain an aqueous phase;

[0088] (3) add the aqueous phase to the oil phase, shear emulsify at a speed of 750 rpm for 45 minutes, then cool to 38℃, add plant extracts, maintain the speed and continue to shear emulsify for 12 minutes, stand at room temperature for 25 minutes, sterilize, fill, to obtain the water-in-oil high-efficiency sunscreen cream.

[0089] Sunscreen cream 3

[0090] The difference from sunscreen cream 1 is that the type of emulsifier is different, Span-20 is used instead of the emulsifier in sunscreen cream, and the amount is 5.5%.

[0091] Sunscreen cream 4

[0092] The difference from sunscreen cream 1 is that the emulsifier is different, and the composition of the emulsifier is: 4.5% cetyl PEG / PPG-10 / 1 dimethicone and 1% PEG-8 glyceryl isostearate.

[0093] Sunscreen cream 5

[0094] The difference from sunscreen cream 1 is that the emulsifier is different, and the composition of the emulsifier is: 4.5% polyglyceryl-2 diisostearate / IPDI copolymer and 1% PEG-8 glyceryl isostearate.

[0095] Sunscreen cream 6

[0096] The difference from sunscreen cream 1 is that the composition of the plant extract is different, and does not contain horseradish extract and cattleya extract, and the composition of the plant extract is: 0.2% tea leaf extract, 0.3% aloe vera extract.

[0097] Sunscreen cream 7

[0098] The difference from sunscreen cream 1 is that the composition of the plant extract is different, and the composition of the plant extract is: 0.2% tea leaf extract, 1.8% horseradish extract, 0.3% aloe vera extract.

[0099] Sunscreen cream 8

[0100] The difference from sunscreen cream 1 is that the composition of the plant extract is different, and the composition of the plant extract is: 0.2% tea leaf extract, 0.3% aloe vera extract, 1.8% cattleya extract.

[0101] Sunscreen cream 9

[0102] The difference from the sunscreen cream 1 is that the ratio of horseradish extract and lilium distichum extract is different, and the composition of the plant extract is: 0.2% tea leaf extract, 1.6% horseradish extract, 0.3% aloe barbadensis extract, 0.2% lilium distichum extract, and the ratio of horseradish extract to lilium distichum extract is 1:0.125.

[0103] Sunscreen cream 10

[0104] The difference from the sunscreen cream 1 is that the ratio of horseradish extract and lilium distichum extract is different, and the composition of the plant extract is: 0.2% tea leaf extract, 0.36% horseradish extract, 0.3% aloe barbadensis extract, 1.44% lilium distichum extract, and the ratio of horseradish extract to lilium distichum extract is 1:4.

[0105] II. Example 2

[0106] The above emulsion is tested.

[0107] 1. Stability

[0108] The average particle size of the prepared emulsion is tested and recorded as D0; the average particle size of the prepared emulsion after being placed at room temperature for 60 days is tested and recorded as D1; the average particle size of the prepared emulsion after being placed at 50℃ for 60 days is tested and recorded as D2; the average particle size of the prepared emulsion after being placed at 4℃ for 60 days is tested and recorded as D3. Then the change amount of D1, D2 and D3 compared with D0 is calculated, and recorded as K1, K2 and K3 in turn. Four parallel groups are set, and the average value is taken, and the results are shown in Table 1; wherein, the smaller the particle size change, the better the stability of the system.

[0109] Table 1: Stability test

[0110]

[0111] It can be known from the test results in Table 1 that the particle size of the emulsion changes little after being stored at room temperature for 60 days, and the particle size changes little when stored in high-temperature and low-temperature environments; it can be known that the sunscreen cream prepared by the present application has high stability.

[0112] It can be known from the comparison of the sunscreen cream 1 and 3 that the colophony PEG / PPG-10 / 1 dimethicone, polyglyceryl-2 diisostearate / IPDI copolymer and PEG-8 glyceryl isostearate used in the present application can excellently stabilize the performance of the emulsion.

[0113] It can be known from the combination of the sunscreen cream 1, 4-5 tests that when one of the cetyl PEG / PPG-10 / 1 dimethicone, polyglyceryl-2 diisostearate / IPDI copolymer and PEG-8 glyceryl isostearate is used in the sunscreen cream 4-5, the emulsion stability is not as good as that of the sunscreen cream 1, and thus it can be known that the cetyl PEG / PPG-10 / 1 dimethicone and polyglyceryl-2 diisostearate / IPDI copolymer have a synergistic effect on the stable emulsion effect in the emulsifier system selected by the application, and the emulsion system has better stability.

[0114] 2, Anti-inflammatory test

[0115] The anti-inflammatory test is performed on the above-prepared sunscreen cream, and the better the inhibition effect of TNF-α and IL-6 release is, the better the anti-inflammatory effect is.

[0116] Consumables: RAW264.7 cells, 24-well plates, ELISA kits.

[0117] Test drugs: LPS, DMEM medium, and the above-prepared sunscreen cream.

[0118] Test process: RAW264.7 cells are inoculated into 24-well plates at a density of 1.20×10 5 Each group is added with LPS (to a concentration of 1.1 μg / mL) + sunscreen cream (to a concentration of 0.012 wt%), the model group is added with LPS (to a concentration of 1.1 μg / mL), and the blank group is not treated, and each group is set in parallel in three groups; then 24 h of incubation at 37℃ and 5% CO2 is continued, the supernatant in the well plate is collected, the TNF-α and IL-6 levels in the supernatant are tested by using the operation steps in the kit instruction, and the result data is specifically shown in Table 2; in Table 2, △TNF-α / μg / mL and △IL-6 / μg / mL represent the reduction amount of the value compared with the model group.

[0119] Table 2: Anti-inflammatory test

[0120]

[0121] It can be known from the combination of Table 2 tests that the sunscreen cream obtained by the application can inhibit the release of TNF-α and IL-6, inhibit inflammation, has better anti-inflammatory performance, and can reduce the acne or skin inflammation.

[0122] Compared with the sunscreen cream 1 and 6, it can be seen that the effect of sunscreen cream 6 on inhibiting the release of TNF-α and IL-6 is significantly reduced compared with that of 1 after omitting the horseradish extract and the lilium lancifolium extract, so it can be known that the use of the horseradish extract and the lilium lancifolium extract can significantly improve the anti-inflammatory performance of the sunscreen cream. When one of the horseradish extract and the lilium lancifolium extract is used in the sunscreen cream 7-8 and the amount is consistent with the total amount of the two in the sunscreen cream 1, the anti-inflammatory effect obtained is lower than that of the sunscreen cream 1, so it can be seen that the horseradish extract and the lilium lancifolium extract prepared in the present application have a synergistic effect on inhibiting inflammation. Further, the effect of the sunscreen cream 9-10 with the changed ratio of the two is lower than that of the sunscreen cream 1-2, that is, the effect of the horseradish extract and the lilium lancifolium extract in the present system is better when the weight ratio is in the range of 1:0.5-1.5.

[0123] 3. Sunscreen test

[0124] The above sunscreen cream is subjected to a sunscreen effect test. The greater the SPF value, the better the sunscreen effect.

[0125] Consumables: SPF-290S sunscreen index analyzer, Optometrics Company, USA; PMMA plate.

[0126] Test process: under the condition of 20±2℃ and relative humidity of 50±5%, a disposable syringe is used to take the test sample, which is evenly applied on the PMMA plate, and after 20 minutes, the transmittance scanning of 290-400nm is carried out, and the sunscreen index SPF value of the sample is calculated according to the software, each group is tested in parallel for 3 times, and the average value is taken, and the results are shown in Table 3.

[0127] Table 3: Sunscreen test

[0128]

[0129] According to the test results in Table 3, the sunscreen cream prepared in the present application has excellent sunscreen effect, and the SPF value is above 48.

Claims

1. A water-in-oil high SPF emulsion, characterized by, The raw materials include, in percentage by weight: 10-35% sunscreen, 2-8% film-forming synergist, 15-40% oil, 3-10% polyhydric alcohol, 0.5-4% plant extract, 3.5-8% emulsifier, 1-7% film former, 0-5% auxiliary material, and the balance water; The film-forming synergist includes isododecane, oxoglutaric acid, lithium montmorillonite dimethylate, trimethylsilyl oxide silicate, and sodium hyaluronate cross-linked polymer; The plant extract includes 0.05-0.5% tea leaf extract, 0.2-1.5% horseradish extract, 0.05-0.5% aloe vera extract, and 0.2-1.5% Lilium brownii extract; The emulsifier includes 1.5-3.2% cetyl PEG / PPG-10 / 1 dimethicone, 1.5-3.2% polyglyceryl-2 diisostearate / IPDI copolymer, and 0.5-1.6% PEG-8 glyceryl isostearate; The oil includes at least one of squalane, jojoba oil, sweet almond oil, macadamia nut oil, caprylic / capric triglyceride, isopropyl myristate, dimethicone, and butyrospermum parkii butter; The sunscreen includes at least one of ethylhexyl methoxy cinnamate, octocrylene, ethylhexyl salicylate, terephthalylidene dicamphor sulfonic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, phenylbenzimidazole sulfonic acid, and homosalate; The polyhydric alcohol includes at least one of ethylene glycol, propylene glycol, glycerin, hexylene glycol, sorbitol, and polyethylene glycol; The film former includes at least one of acrylates copolymer, VP / hexadecene copolymer, polyvinylpyrrolidone, vinyl dimethicone / methicone silsesquioxane crosspolymer, styrene / acrylates copolymer, and polysilicone-11; The auxiliary material includes at least one of preservative, chelating agent, fragrance, and pH adjuster.

2. A method for preparing the water-in-oil high efficiency sunscreen emulsion according to claim 1, characterized in that, The method includes the following steps: (1) heating the oil and the sunscreen, adding the emulsifier, the film former, and the film-forming synergist, and stirring to obtain an oil phase; (2) heating water, adding the polyhydric alcohol and the auxiliary material, and stirring to obtain an aqueous phase; (3) adding the aqueous phase to the oil phase, shear emulsifying, then cooling, adding the plant extract, shear emulsifying, aging, sterilizing, filling, and obtaining the water-in-oil high-efficiency sunscreen cream.

3. The method of claim 2, wherein, The heating in step (1) is to 60-85°C, and the heating in step (2) is to 60-85°C; the cooling in step (3) is to 35-50°C.

4. The use of the water-in-oil high efficient sunscreen emulsion according to claim 1 or prepared by the method according to any one of claims 2-3 in the preparation of skin preparations, characterized in that, The water-in-oil high-efficiency sunscreen cream is used in skin preparation in an amount of 1-50 wt%.

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