Detection sensor
By using a combination of HARM structure and casein micelle barrier layer in biosensors, the problems of non-specific binding and low sensitivity of the sensors are solved, enabling accurate detection and multiplexing of target molecules.
CN120721811BActive Publication Date: 2026-06-05CANATU OY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-28
- Publication Date
- 2026-06-05
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Figure CN120721811B_ABST
Abstract
A sensor for determining the presence of at least one target molecule in a sample is disclosed. The sensor comprises a layer formed of high aspect ratio molecular structures (HARM structures) and a blocking layer on the layer formed of HARM structures, wherein the blocking layer is formed of a plurality of casein micelles, wherein the casein micelles comprise primary amines, wherein at least part of the primary amines are functionalized with an amine-reactive crosslinker and cavities are formed between the plurality of casein micelles. Further, a method for determining the presence of at least one target molecule in a sample is disclosed. Further, a process for preparing a sensor for determining the presence of at least one target molecule in a sample is disclosed. Further, a kit for determining the presence of at least one target molecule in a sample is disclosed.
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Citation Information
Patent Citations
Biolayer interferometry measurement of biological targets
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