Method for selectively preparing indole compounds or carbazole compounds through alkali salt regulated manganese catalysis
The method of regulating manganese catalysts through alkali salts solves the problems of noble metal catalysts and harsh reaction conditions in the existing technology, achieves high-selectivity and high-yield synthesis of indole and carbazole compounds, and is suitable for industrial production.
CN120757482APending Publication Date: 2025-10-10INNER MONGOLIA UNIV FOR THE NATITIES
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Patent Information
- Application Number
- CN202510901866.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-01
- Publication Date
- 2025-10-10
AI Technical Summary
Technical Problem
Existing methods for synthesizing 3-acylated methylated indole and its derivatives or carbazole compounds require precious metal catalysts and harsh reaction conditions, which limits industrial production.
Method used
Alkali salts are used to regulate manganese catalysts, and by adjusting the type of alkali salts, indole compounds or carbazole compounds can be selectively prepared. 2-arylindole or substituted 2-arylindole is used to react with α-chloroaryl ethyl ketone under mild reaction conditions.
Benefits of technology
The method achieves high selectivity and high yield compound synthesis, is suitable for industrial production, and has high safety.
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Abstract
The invention discloses a method for selectively preparing an indole compound or a carbazole compound by alkali salt regulation and manganese catalysis, which comprises the following steps of: selectively synthesizing the indole compound or the carbazole compound by taking 2-aryl indole or substituted 2-aryl indole and alpha-chloro aryl ethyl ketone or substituted alpha-chloro aryl ethyl ketone as initial raw materials; conditions are mild, selectivity, yield and safety are high, and industrial production is facilitated; according to the invention, 2-aryl indole or substituted 2-aryl indole and alpha-chloro-aryl ethyl ketone or substituted alpha-chloro-aryl ethyl ketone are used as initial raw materials for the first time, and alkali salt is regulated to regulate the reaction so as to selectively prepare indole compounds or carbazole compounds.
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