Flexible intelligent drug delivery device driven by liquid activated battery

Abstract

The invention discloses a flexible intelligent drug delivery device driven by a liquid activated battery, and belongs to the field of transdermal drug delivery. The device comprises a flexible liquid activation battery array, a flexible excitation conduction electrode array and a hydrogel layer used for delivering medicine. The flexible liquid activated battery array is welded on the flexible excitation conduction electrode array to form a coplanar structure, and the coplanar structure and the flexible excitation conduction electrode array are jointly embedded into the hydrogel layer. The liquid activated battery provided by the invention can provide miniaturized, low-cost and flexible power supply support, meets the requirement of one-time throwing, and generates an adjustable stable electric field at the same time, thereby driving drugs in the hydrogel layer to permeate to the skin as required. Through the hydrogel with high hydratability and biocompatibility in the system, transdermal absorption of the medicine is realized, and the system has the characteristics of high flexibility and adaptability and can be comfortably attached to the skin.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of electrochemistry and transdermal drug delivery, and in particular to a flexible smart drug delivery device powered by a liquid activated battery. BACKGROUND

[0002] Transdermal drug delivery refers to a drug delivery method that absorbs drugs through the skin to achieve systemic or local therapeutic effect, which has the advantages of non-invasiveness and patient compliance. Traditional transdermal drug delivery technology is mainly based on the small size and lipophilicity of drug molecules, allowing the drug to diffuse into the body through the skin. Common application forms include patches, gels, and creams, but due to the presence of the skin barrier, only a small portion of the drug can passively diffuse through the skin, and the diffusion rate is slow, making it challenging to maintain an effective transdermal drug delivery level. Iontophoresis is a method of applying a weak voltage to the skin to induce drug migration electrically and thereby deliver the drug through the skin. This technology addresses the limitations of traditional transdermal drug delivery, such as slow absorption rate and difficulty in precise control.

[0003] Existing iontophoretic transdermal drug delivery power strategies mainly use direct current power sources. Common direct current power sources include dry batteries and storage batteries, but traditional batteries are too large to be integrated into miniaturized, wearable transdermal drug delivery devices. Additionally, these traditional batteries may generate hazardous waste during use. Liquid activated batteries are flexible power sources that generate electric current through a reaction with a liquid, providing stable power support for devices. Compared to traditional power sources, liquid activated batteries are small in size and light in weight, enabling the miniaturization and portability of devices. Additionally, liquid activated batteries are low-cost disposable and environmentally friendly, meeting the needs of high-frequency replacement or consumables, and providing a new battery strategy for transdermal drug delivery. SUMMARY

[0004] The present application aims to address the shortcomings of existing technology and products by providing a flexible smart drug delivery device powered by a liquid activated battery to solve the problems of iontophoretic power supply and efficient transdermal drug delivery.

[0005] The purpose of the present application is achieved by the following technical solutions: a liquid-activated battery-driven flexible intelligent drug delivery device, comprising a flexible liquid-activated battery array, a flexible excitation conduction electrode array and a hydrogel layer for delivering drugs; the flexible liquid-activated battery array is fixed on the flexible excitation conduction electrode array, realizes electrical connection, forms a single-layer coplanar structure, and is embedded in the hydrogel layer together; the flexible liquid-activated battery array is composed of a flexible liquid-activated battery unit string; the flexible liquid-activated battery unit adopts a layered design, and from bottom to top includes a flexible substrate layer, an anode waterproof adhesive layer, a silver / silver chloride cathode, a magnesium anode, an electrolyte waterproof adhesive layer and an electrolyte film layer; the flexible excitation conduction electrode array is composed of a plurality of pairs of gold-plated copper electrodes; the silver / silver chloride cathode and the magnesium anode are located on both sides of the flexible substrate layer respectively; the hydrogel adopts a high-hydration and biocompatible hydrogel.

[0006] Further, the flexible substrate layer adopts a flexible material with a thickness of 0.05-0.1mm, and the flexible material includes polyethylene terephthalate, polydimethylsiloxane or polyimide.

[0007] Further, the magnesium anode adopts a magnesium foil with a thickness of 80-100μm, which is adhered to the flexible substrate layer through the anode waterproof adhesive layer.

[0008] Further, the silver / silver chloride cathode adopts silver / silver chloride ink with a thickness of 80-100μm, which is printed on the flexible substrate layer through a screen printing process.

[0009] Further, the electrolyte film layer is made of a cellulose film with a thickness of 80-100μm and a porous capillary structure, the surface of the cellulose film is uniformly coated with 100-400mM of electrolyte solution, and the electrolyte solution is left to dry completely at room temperature to form a separator layer with excellent ion conductivity; the electrolyte solution is any one of sodium chloride, potassium chloride or ammonium chloride solution.

[0010] Further, the copper electrode surface of the gold-plated copper electrode is plated with a gold layer with a thickness of 1-3μm.

[0011] Further, the gold-plated copper electrode is processed into a rectangular flexible excitation conduction electrode with a width of 150mil, a snake-shaped flexible excitation conduction electrode, or an arrayed rectangular electrode flexible excitation conduction electrode or an arrayed snake-shaped electrode flexible excitation conduction electrode to control the electroosmotic efficiency and the electroosmotic efficiency.

[0012] Further, the hydrogel layer forms an electric field after being powered by a flexible excitation conductive electrode array, and drives the charged nutrient or drug molecules to move directionally, the hydrogel layer being a single pair of electrode adaptive hydrogel layer or an array electrode adaptive hydrogel layer, and being used for regulating the release rate of drugs under different electric field driving.

[0013] Further, the hydrogel layer contains water-soluble active ingredients, and the active ingredients include 1wt% of a nicotinamide water solution, a water solution of vitamin (such as panthenol, a vitamin C derivative), an anti-inflammatory (such as sodium salicylate) or a moisturizing (such as sodium hyaluronate) ingredient.

[0014] The beneficial effects of the present application are as follows: the present application provides a liquid activated battery driven flexible intelligent drug delivery device, which realizes the miniaturization, portability, low cost disposable and environmental friendliness of the device. By adopting the combination of liquid activated battery and iontophoresis, the liquid activated battery driven flexible intelligent drug delivery device provided by the present application can effectively realize the efficient absorption of drugs and the low-cost sustainable power supply. By providing a stable electric field driving through the liquid activated battery, the drug molecules produce directional migration in the hydrogel, thereby improving the transdermal absorption efficiency. At the same time, combined with the physical penetration mechanism of iontophoresis, the uniform penetration of drugs in the skin barrier is ensured, and the drug delivery effect is significantly enhanced. The device is convenient to integrate and easy to use.

[0015] Compared with traditional transdermal drug delivery devices, the flexible intelligent drug delivery device of the present application also has the advantages of high drug utilization rate, high transdermal absorption efficiency, controllable delivery dose and the like. The present application realizes the directional migration and deep transdermal absorption of drug molecules by providing a stable electric field through a liquid activated battery, combined with the iontophoresis mechanism, effectively improving the drug delivery efficiency. At the same time, the present application has the characteristics of low cost, simple operation and environmental friendliness. The flexible design of the present application makes it suitable for transdermal application in different parts, providing a precise and sustainable drug delivery means, and providing a safe and reliable solution for non-invasive treatment. According to the above advantages, the device of the present application can be widely used in the fields of medical treatment and health care. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 is a structure schematic diagram of a rectangular electrode liquid activated battery driven flexible intelligent drug delivery device provided by an embodiment of the present application;

[0017] Figure 2 is a structure schematic diagram of a serpentine electrode liquid activated battery driven flexible intelligent drug delivery device provided by an embodiment of the present application;

[0018] Figure 3 is a structure schematic diagram of an arrayed rectangular electrode liquid activated battery driven flexible intelligent drug delivery device provided by an embodiment of the present application;

[0019] Figure 4 is a schematic diagram of a flexible smart drug delivery device structure driven by arrayed serpentine liquid activated battery provided by embodiments of the present application;

[0020] Figure 5 is a schematic diagram of a liquid activated battery structure provided by embodiments of the present application; wherein (a) is an elevation view and (b) is an exploded view;

[0021] Figure 6 is a liquid activated battery electrolyte concentration test diagram provided by embodiments of the present application;

[0022] Figure 7 is a liquid activated battery working time test diagram provided by embodiments of the present application;

[0023] Figure 8 is a liquid activated battery constant current discharge test diagram provided by embodiments of the present application;

[0024] Figure 9 is a liquid activated battery load performance test diagram provided by embodiments of the present application;

[0025] Figure 10 is a liquid activated battery series open circuit voltage test diagram provided by embodiments of the present application;

[0026] Figure 11 is a liquid activated battery power density curve test diagram provided by embodiments of the present application;

[0027] Figure 12 is a flexible smart drug delivery device drug spectrum analysis diagram provided by embodiments of the present application;

[0028] Figure 13 is a flexible smart drug delivery device drug linearity test diagram provided by embodiments of the present application;

[0029] Figure 14 is a flexible smart drug delivery device drug electro-osmosis efficiency test diagram provided by embodiments of the present application;

[0030] Figure 15 is a liquid activated battery driven iontophoresis mask structure exploded view provided by embodiments of the present application;

[0031] In the figure: flexible liquid activated battery cell 1, flexible substrate layer 11, anode waterproof adhesive layer 12, silver / silver chloride cathode 13, magnesium anode 14, electrolyte waterproof adhesive layer 15, electrolyte film layer 16, rectangular flexible excitation conductive electrode 2, single pair of electrode adapted hydrogel layer 3, serpentine flexible excitation conductive electrode 4, arrayed rectangular electrode flexible excitation conductive electrode 5, arrayed electrode adapted hydrogel layer 6, arrayed serpentine electrode flexible excitation conductive electrode 7, face mask 8. DETAILED DESCRIPTION

[0032] The embodiments, features and aspects of the present disclosure will be described in detail below with reference to the drawings, but are not limited to the present disclosure. Any one of the embodiments expanded based on the embodiments of the present disclosure, all other embodiments obtained by those skilled in the art without making creative efforts, belong to the scope of protection of the present disclosure. The same reference signs in the drawings represent the same or functionally similar elements. Although various aspects of the embodiments are shown in the drawings, the drawings are not necessarily drawn to scale unless specifically indicated.

[0033] In addition, in order to better illustrate the present disclosure, numerous specific details are given in the specific embodiments below, but those skilled in the art should understand that the present disclosure can also be implemented without certain specific details, and some methods and means familiar to those skilled in the art are not described in detail in order to highlight the main idea of the present disclosure.

[0034] As Figures 1-4 shown, the embodiments of the present disclosure provide a liquid activated battery driven flexible intelligent drug delivery device, which comprises: a flexible liquid activated battery array, a flexible excitation conductive electrode array, and a hydrogel layer for delivering drugs. The flexible liquid activated battery array is welded on the flexible excitation conductive electrode array to realize electrical connection, form a single-layer coplanar structure, and be embedded in the hydrogel layer together.

[0035] The flexible excitation conductive electrode array is composed of multiple pairs of electrodes for applying a stable electric field to the hydrogel layer. The flexible excitation conductive electrode array selects gold-plated copper electrodes as conductive electrodes. The gold-plated copper electrodes are made by using flexible circuit board etching printing technology, and the copper electrodes have a thickness of 35 μm, on which a gold layer with a thickness of 1-3 μm is plated by surface treatment process to improve corrosion resistance. The gold-plated copper electrodes can be processed into rectangular flexible excitation conductive electrodes 2 or serpentine flexible excitation conductive electrodes 4 with a width of 150 mil, and one pair of gold-plated copper electrodes is connected to the anode and cathode of the battery respectively. The gold-plated copper electrodes are attached to the hydrogel, so that the system can maintain good adhesion and conductivity in various complex skin curved surface areas. The gold-plated copper electrodes can be further processed into arrayed rectangular electrode flexible excitation conductive electrodes 5 or arrayed serpentine electrode flexible excitation conductive electrodes 7 to control the area and efficiency of electroosmosis,

[0036] The hydrogel layer forms an electric field after being powered by the flexible excitation conducting electrode array, driving the directional movement of charged nutrient or drug molecules, improving the penetration depth and efficiency of active substances, and being suitable for areas with thick skin barrier or difficult absorption. The hydrogel can load specific active substances such as vitamin C, niacinamide or hyaluronic acid according to application requirements, for cosmetic skin care, and can also load anti-inflammatory agents or analgesic drugs to achieve transdermal treatment. The hydrogel layer can use high-hydrating and biocompatible hydrogels such as polyacrylamide hydrogel, chitosan hydrogel or agarose hydrogel, which can be directly contacted with human skin. The hydrogel layer can be cut into single-pair electrode adaptive hydrogel layer 3 or array electrode adaptive hydrogel layer 6 accordingly, and the release rate of the drug can be regulated under different electric field driving.

[0037] As Figure 5As shown, the flexible liquid-activated battery array is composed of a flexible liquid-activated battery unit 1 string for providing sufficient electric field intensity; the flexible liquid-activated battery unit 1 adopts a layered design, including a flexible substrate layer 11, an anode waterproof adhesive layer 12, a silver / silver chloride cathode 13, a magnesium anode 14, an electrolyte waterproof adhesive layer 15, and an electrolyte film layer 16, all of which are designed to be flexible, meeting the requirements of miniaturization, flexibility, and light weight of the flexible intelligent drug delivery device. The flexible substrate layer 11 is made of flexible materials such as polyethylene terephthalate, polydimethylsiloxane, or polyimide with a thickness of 0.05-0.1 mm, which can be cut into any area according to requirements. The magnesium anode 14 is made of magnesium foil with a thickness of 80-100 μm and high capacity, which can be patterned by laser cutting process. The magnesium anode 14 is 1 cm long and 1 cm wide, and is adhered to the flexible substrate layer 11 by the anode waterproof adhesive layer 12, which is a waterproof tape with a length of 0.5 cm, a width of 0.5 cm, and a thickness of 0.15 mm. The silver / silver chloride cathode 13 is printed by screen printing process to be 1 cm long, 1 cm wide, and 80-100 μm thick, and is directly and accurately printed on the flexible substrate layer 11 on the other side of the magnesium anode 14. After printing, the printed product is heated and cured at 70°C for 90 minutes to enhance the conductivity and stability. The electrolyte film layer 16 is made of cellulose film with a specification of 1 layer (thickness of 80-100 μm), and the cellulose film is laser-cut into a long strip with a length of 4 cm and a width of 1 cm to ensure accurate matching between components. The cellulose film has a porous capillary structure that can quickly absorb liquid and promote battery startup; the surface of the cellulose film is uniformly coated with 100-400 mM of electrolyte solution, and then left to dry at room temperature to form a separator layer with excellent ion conductivity, ensuring the stability of ion conduction during battery operation. The electrolyte solution can be any one of sodium chloride, potassium chloride, or ammonium chloride solution. The silver / silver chloride cathode 13 and the magnesium anode 14 are tightly adhered to the electrolyte film layer 16 by the electrolyte waterproof adhesive layer 15. The electrolyte waterproof adhesive layer 15 is a waterproof tape with an area of 2 cm long and 0.5 cm wide, and a thickness of 0.15 mm.

[0038] The structure of the flexible intelligent drug delivery device driven by the liquid-activated battery of the present application after integration of the flexible liquid-activated battery unit 1 is as follows Figure 5The working principle is as follows: when the liquid enters the battery, the electrolyte film layer 16 rapidly absorbs the liquid, dissolves the pre-coated electrolyte therein, and thus forms an ion solution with good electrical conductivity. The anode and the cathode undergo electrochemical reactions in the liquid medium, the magnesium anode 14 acts as an anode to undergo oxidation reaction, releases electrons and generates magnesium ions. The silver / silver chloride in the silver / silver chloride cathode 13 is reduced by accepting electrons, thereby completing the basic electrochemical process of the battery. Through the external load of the circuit, electrons flow from the anode to the cathode, forming a stable current output. During the liquid activation process, the capillary effect of the electrolyte film layer 16 ensures that the liquid is rapidly distributed throughout the battery structure, while the hydrophobic edges designed on the electrode surface effectively limit the overflow of the liquid, ensuring the stability of the battery performance. The entire reaction process is controlled by the electrolyte concentration, the amount of liquid injection, and the ratio between the anode and cathode area, and the optimal performance of the battery is ensured during the design process.

[0039] As shown in Figure 6 To evaluate the effect of electrolyte concentration on the performance of the battery, sodium chloride was used as the electrolyte, and 100 mM, 250 mM and 400 mM sodium chloride solutions were used for comparative testing of the battery. The silver / silver chloride cathode 13 and the magnesium anode 14 described above were used, and different concentrations of sodium chloride solution were coated on the cellulose paper of the electrolyte film layer 16 as the electrolyte layer. The results show that the liquid activated battery with different concentrations of sodium chloride solution can stably output voltage at a concentration of 100 mM-400 mM. This indicates that the battery performance can be achieved without interference from the moisture of the mask or the composition of the human facial sweat during use, ensuring the stable output ability of the battery.

[0040] As shown in Figure 7 To evaluate the stability of the liquid activated battery during long-term operation, a continuous discharge stability test was performed. Under the conditions described above, 400 mM sodium chloride solution was selected as the electrolyte, and the battery was connected to a constant load of 200 kΩ for operation, and the voltage-time curve of the battery was recorded. The results show that the voltage of the liquid activated battery only decreases slightly within 1200 seconds, from the initial voltage of 1.56 V to about 1.40 V, indicating that it maintains good voltage stability during operation. The experimental results show that the liquid activated battery of the present application not only has a long discharge time, but also maintains the stability of the voltage output during long-term operation.

[0041] As shown in Figure 8 To evaluate the capacity characteristics of the liquid activated battery, the chronopotentiometry method was used to test the constant current discharge of the battery per unit area. For a single battery, the area of the magnesium anode 14 was used as the representative of the battery area, and the following unit area was 1 cm 2The area of the magnesium anode 14 is taken as a reference. In the chronopotentiometry method, the current during the discharge of the battery is controlled to a constant value of 1 mA / cm 2 The relationship between the open-circuit voltage of the battery and the discharge capacity of the battery is recorded. The results show that the voltage of the battery gradually decreases with the increase of the discharge capacity. The initial voltage is about 1.6 V, and finally decreases to near 0 V as the discharge proceeds, and the test capacity is close to 5 mAh / cm 2 .

[0042] As shown in Figure 9 , in order to evaluate the performance of the liquid activated battery under different load conditions, a load capacity test was carried out to test the discharge characteristics within 3000s under the conditions of load resistance values of 25kΩ, 75kΩ and 200kΩ, respectively, and the cut-off voltage was set to 1V. The results show that under each load condition, the liquid activated battery shows stable output performance and sufficient working time, which indicates the reliability and stability of the battery in the power supply system.

[0043] As shown in Figure 10 , in order to evaluate the modular expansion capability of the liquid activated battery, an open-circuit voltage output test of a series-connected battery pack was carried out. The results show that the open-circuit voltage of a single battery is about 1.5V, and the open-circuit voltage after series connection shows a good linear growth relationship. This verifies the modular expansion performance of the battery of the present application, which can achieve higher voltage output by series connection to adapt to the needs of different devices. At the same time, the controllable voltage output provides a basis for realizing personalized on-demand drug delivery.

[0044] As shown in Figure 11 , in order to evaluate the power output performance of the liquid activated battery, a power density curve test was carried out. The battery was connected to a load, and the load was selected as 75Ω, 750Ω, 2.2kΩ, 5.1kΩ, 10kΩ, 25kΩ, 75kΩ, 150kΩ, 200kΩ, respectively. The voltage across the battery under different conditions and the current per unit area were recorded, and the output power density of the battery was obtained from the power calculation formula. The results show that the power density of the liquid activated battery reaches a maximum value (about 42μW / cm 2 ) in the load interval of 10-25kΩ. This shows that the battery has the best power output performance in a certain working voltage range, which can meet the power consumption demand of flexible electronics.

[0045] In this embodiment, a representative active skin care ingredient, nicotinamide, was selected to verify a kind of iontophoresis mask driven by a liquid activated battery designed in the present application.

[0046] The hydrogel layer can be loaded with different drugs as needed. In this embodiment, a high-efficiency nicotinamide-loaded hydrogel is prepared by free radical polymerization. First, 2.32 g of acrylamide is dissolved in a 1 wt% nicotinamide aqueous solution (268.2 mg of nicotinamide dissolved in 26.82 mL of deionized water), and 10 mg of N,N'-methylenebisacrylamide is used as a crosslinking agent to prepare a hydrogel matrix. To facilitate the polymerization reaction, 2M ammonium persulfate is used as an initiator, and 0.8M tetramethyl ethylenediamine is used as an accelerator. 0.654 mL of tetramethyl ethylenediamine solution and 0.216 mL of ammonium persulfate solution are added in a volume ratio. The above pre-polymerization solution is mixed at 27°C for about 10 minutes, and then cast into a mold. After the gelation is completed, a hydrogel with high mechanical strength and excellent biocompatibility is obtained.

[0047] As shown in Figures 12-13 In the present application, the absorbance of nicotinamide solutions with different concentrations is tested to verify the feasibility of using a UV spectrophotometer to determine the concentration of nicotinamide. In this embodiment, the absorbance of 10 mL of pure water without nicotinamide and solutions with nicotinamide concentrations of 1 μg / mL, 5 μg / mL, 10 μg / mL, 20 μg / mL, 50 μg / mL, and 100 μg / mL is tested by a UV spectrophotometer. Figure 12 The results show that the higher the drug concentration, the greater the absorbance. In the wavelength range of 240-300 nm, each concentration solution shows a clear absorption peak, and the absorbance increases significantly with increasing concentration. The peak value of the absorption peak and the concentration of the solution are fitted to a standard curve, Figure 13 The results show that there is a good linear relationship between absorbance and concentration, with a linear correlation coefficient R 2 = 0.99876, and the relationship equation between absorbance and concentration is y = 0.03652x - 0.04908, which provides a reliable basis for subsequent quantitative analysis of the transdermal delivery efficiency of nicotinamide.

[0048] As shown in Figure 14To verify the actual effect of the system in transdermal delivery of nicotinamide, in-vitro drug release experiments were performed. The above prepared nicotinamide-loaded hydrogel was cut into a unit with a length of 15 cm, a width of 7 cm, and a thickness of 2 mm, ensuring good matching with the area of the flexible liquid activated battery array and the flexible excitation conducting electrode array. The experimental system was clamped in a diffusion cell, with the upper layer being the nicotinamide-loaded hydrogel and the electrode assembly, and 10 mL of pure water being added to the lower layer to ensure that nicotinamide can be effectively released to the lower layer solution. In the experiment, 3V voltage provided by two units of liquid activated batteries in series was used to drive drug migration, and a voltage group without electric stimulation (0V) was set as a control, and both groups were continuously operated for 1 hour. The transdermally released nicotinamide was captured by the lower layer solution, and its concentration was determined by ultraviolet spectrophotometry. The results showed that the concentration of nicotinamide released to the lower layer solution under the condition of electric stimulation was 20.68 μg / mL, which was significantly higher than 5.12 μg / mL in the group without electric stimulation, indicating that the driving of the electric field significantly improved the transdermal migration efficiency of nicotinamide. This result verifies the effectiveness of the liquid activated battery driven iontophoresis system in transdermal drug delivery.

[0049] The liquid activated battery driven flexible intelligent drug delivery device provided by the present application can be integrated in different devices according to needs to realize personalized customization. As shown in Figure 15 As shown in the structure diagram of the liquid activated battery driven flexible intelligent drug delivery device provided by the embodiment of the present application integrated in a mask. It includes: a flexible liquid activated battery array, an array electrode adapted hydrogel layer 6 for delivering drugs, an arrayed serpentine electrode flexible excitation conducting electrode 7, and a mask 8. In use, the flexible liquid activated battery array is infiltrated with the electrolyte film layer by the essence liquid in the mask, and the flexible liquid activated battery array starts to work. The arrayed serpentine electrode flexible excitation conducting electrode 7 applies an electric field to the hydrogel layer, thereby delivering the drug in the drug-loaded hydrogel to the facial skin.

[0050] The liquid activated battery driven flexible intelligent drug delivery device of the present application has the advantages of environmental protection, low cost, and simple operation. Through the power supply mode of the liquid activated battery, external power supply is not required, and efficient transdermal delivery of nicotinamide is realized. Experiments show that the device can significantly improve the transdermal absorption efficiency of active molecules, and has broad application potential in the field of transdermal drug delivery. Through the physical penetration mechanism of iontophoresis, it ensures the efficiency and uniformity of drug delivery, and provides a new solution for non-invasive drug delivery.

[0051] Other embodiments of the application will be apparent to those skilled in the art from consideration of the specification and practice of the application disclosed herein. It is intended that the specification and examples be considered as exemplary only, with a true scope of the application being indicated by the following claims.

[0052] It should be understood that the application is not limited to the precise construction hereinafter described and as shown in the attached drawings, and that various modifications and changes can be made by those skilled in the art without departing from the scope of the application.

Claims

1. A liquid-activated battery-driven flexible smart drug delivery device, characterized in that: The invention comprises a flexible liquid-activated battery array, a flexible excitation conductive electrode array and a hydrogel layer for delivering drugs; the flexible liquid-activated battery array is fixed on the flexible excitation conductive electrode array to achieve electrical connection, form a single-layer coplanar structure, and are embedded in the hydrogel layer; the flexible liquid-activated battery array is composed of a series of flexible liquid-activated battery units (1); the flexible liquid-activated battery units (1) adopt a layered design, and comprise, from bottom to top, a flexible base layer (11), an anode waterproof adhesive layer (12), a silver / silver chloride cathode (13), a magnesium anode (14), an electrolyte waterproof adhesive layer (15), and an electrolyte film layer (16); the silver / silver chloride cathode (13) and the magnesium anode (14) are respectively located on both sides of the flexible base layer (11); the flexible excitation conductive electrode array is composed of a plurality of pairs of gold-plated copper electrodes.

2. The liquid-activated battery-driven flexible smart drug delivery device according to claim 1, characterized in that: The flexible base layer (11) is made of a flexible material with a thickness of 0.05-0.1 mm, and the flexible material includes polyethylene terephthalate, polydimethylsiloxane or polyimide.

3. The liquid-activated battery-driven flexible smart drug delivery device according to claim 1, characterized in that: The magnesium anode (14) is made of magnesium foil with a thickness of 80-100 μm and is bonded to the flexible base layer (11) via an anode waterproof bonding layer (12).

4. The liquid-activated battery-driven flexible smart drug delivery device according to claim 1, characterized in that: The silver / silver chloride cathode (13) is made of silver / silver chloride ink with a thickness of 80-100 μm and is printed on the flexible substrate layer (11) through a screen printing process.

5. The liquid-activated battery-driven flexible smart drug delivery device according to claim 1, characterized in that: The electrolyte film layer (16) is made of a cellulose film with a thickness of 80-100 μm and a porous capillary structure, and the surface of the cellulose film is evenly coated with a 100-400 mM electrolyte solution; the electrolyte solution is any one of sodium chloride, potassium chloride or ammonium chloride solution.

6. The liquid-activated battery-driven flexible smart drug delivery device according to claim 1, characterized in that: The copper electrode surface of the gold-plated copper electrode is plated with a gold layer with a thickness of 1-3 μm.

7. The liquid-activated battery-driven flexible smart drug delivery device according to claim 1, characterized in that: The gold-plated copper electrode is processed into a rectangular flexible excitation conduction electrode (2) or a serpentine flexible excitation conduction electrode (4) with a width of 150 mil, or processed into an arrayed rectangular electrode flexible excitation conduction electrode (5) or an arrayed serpentine electrode flexible excitation conduction electrode (7).

8. The liquid-activated battery-driven flexible smart drug delivery device according to claim 1, characterized in that: The hydrogel layer forms an electric field after being energized by the flexible excitation conductive electrode array, driving the directional movement of charged nutrient or drug molecules. The hydrogel layer is a single pair of electrode-adapted hydrogel layer (3) or an array electrode-adapted hydrogel layer (6), and is used to regulate the release rate of the drug under different electric field driving.

9. The liquid-activated battery-driven flexible smart drug delivery device according to claim 8, characterized in that: The hydrogel layer contains water-soluble active ingredients, which include 1 wt% niacinamide aqueous solution, and aqueous solutions of vitamins, anti-inflammatory or moisturizing ingredients.

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