Permeation enhancers for gastrointestinal synthetic epithelium liners

CN120813380APending Publication Date: 2025-10-17CENTIS BIO
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Patent Information

Application Number
CN202480011711.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2023-09-28
Filing Date
2024-01-19
Publication Date
2025-10-17

AI Technical Summary

Technical Problem

Many drugs cannot be effectively absorbed through the epithelial lining of the gastrointestinal tract due to their physical and chemical properties, especially biologics and large molecule drugs, resulting in poor efficacy when administered orally.

Method used

A synthetic liner (GSEL) formed in situ in the gastrointestinal tract, combined with a permeation enhancer, enhances drug absorption in intestinal tissue. The synthetic liner, comprising a polymer precursor, an oxygen source, and a permeation enhancer, polymerizes in vivo upon oral administration of the composition, forming a coating that improves drug absorption.

Benefits of technology

It significantly enhances the absorption efficiency of drugs such as macromolecules and biologics in the gastrointestinal tract, overcomes the limitations of the epithelial lining barrier, and achieves more efficient drug delivery.

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Abstract

The present disclosure relates to synthetic liners of the gastrointestinal (GI) tract, "gastrointestinal synthetic epithelium liners" or "GSELs" that can modulate the absorption of drugs, nutrients and other substances in the GI tract, and one or more penetration enhancers that facilitate such absorption. GSEL is a temporary liner on the inner surface of the GI tract lumen, which may have its active agent (e.g., a drug, nutrient, or other substance) in intimate contact with the GI mucosa such that the active agent may be absorbed over a long period of time.
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Citation Information

Patent Citations

  • Tissue catalyzed growth of polymer as epithelial linings for therapy

    WO2021119350A1

  • Synthetic tissue barriers and uses thereof

    WO2021119354A1