Pesticidal compositions containing fluopyram and their use in the control of leaf blotch

Abstract

The application discloses a pesticide composition containing fluopyram and application of the pesticide composition in prevention and treatment of apple alternaria leaf spot, and belongs to the technical field of pesticides. A volatile oil extract of Alpinia galanga and a volatile oil extract of Eupatorium fortunei are obtained, and in indoor tests, the colony diameters of apple Alternaria alternata are all reduced, which indicates that the volatile oil extract of Alpinia galanga and the volatile oil extract of Eupatorium fortunei can inhibit the mycelium growth of apple Alternaria alternata. The volatile oil extract is used as a synergistic extract, combined with fluopyram, and added with various additives to prepare the pesticide composition containing fluopyram. In field tests, the disease index of fruit trees is all reduced, which indicates that apple Alternaria alternata is inhibited, and the relative prevention and treatment efficiency of the compound group is the highest and reaches 80.05%. The pesticide composition containing fluopyram is prepared by compounding fluopyram and the synergistic extract containing the volatile oil extract of Alpinia galanga and the volatile oil extract of Eupatorium fortunei, the pesticide composition can better inhibit apple Alternaria alternata, and is suitable for development of a pesticide for preventing and treating apple alternaria leaf spot.

Description

Technical Field

[0001] This invention relates to the field of pesticide technology, specifically to pesticide compositions containing fluopyram and their application in the control of leaf spot disease. Background Technology

[0002] Apple, scientific name Malus pumila Mill. Apples belong to the genus *Malus* in the family Rosaceae. Native Chinese apple species were historically known as "Nai" or "Linqin." Apples are rich in carotene, vitamin C, minerals (such as potassium, phosphorus, magnesium, and calcium), and dietary fiber, offering numerous health benefits. Apples are one of the most widely cultivated and sold fruits globally, with a long history of cultivation and a wide distribution. my country is a major apple producer and consumer, consistently ranking first in the world in apple production, accounting for more than half of global production.

[0003] Apple leaf spot, also known as apple brown spot, is caused by Alternaria applea (… Alternaria mali This disease, caused by infection, affects apple trees. In most years, the disease begins to appear in late June, peaking from late July to early August. Early spring rains lead to earlier onset, while more frequent autumn rains exacerbate the disease. It ceases to occur in early October. The disease primarily damages apple leaves, but also affects petioles, one-year-old branches, and fruit, causing premature leaf drop. In severe cases, it weakens the tree, reduces fruit yield and quality, and can even lead to infection with multiple pathogens during storage, resulting in rot.

[0004] Fluopyram, marketed by Bayer, is a pesticide used to control root-knot nematodes, powdery mildew, gray mold, leaf mold, sclerotinia rot, leaf spot, and brown rot. While fluopyram can be applied directly, its effectiveness is limited when used alone; therefore, most manufacturers currently use it in combination with other pesticides. There are various ways to combine it, such as by combining it with other synthetic antimicrobial agents, natural drugs, and their extracts.

[0005] Red cardamom ( Alpinia galanga (L.) Willd. is a plant belonging to the ginger family and the genus *Alpinia*. It is widely distributed in tropical Asian provinces of my country, growing in shady, damp forests, thickets, and grasslands in mountain valleys at altitudes of 100-1300 meters. The fruit is oblong, 1-1.5 cm long and about 7 mm wide, slightly constricted in the middle, brown or dark red when ripe, smooth or slightly wrinkled, thin, indehiscent, and easily broken by hand, containing 3-6 seeds. The fruit of *Alpinia galanga* is used medicinally, possessing properties that dispel dampness, cold, invigorate the spleen, and aid digestion.

[0006] Centipede grass ( Eremochloa ciliaris(L.) Merr.) is a perennial herb belonging to the Poaceae family and the genus *Lysimachia*. It grows in grassy areas on hillsides and roadsides. Both fresh and dried *Lysimachia* are readily eaten by horses, cattle, and sheep. The grass is soft, highly usable, and easily digestible for ruminant livestock, making it suitable for their feed.

[0007] Although there is some understanding of the efficacy of fluopyram, cardamom, and centipede grass, the effectiveness of using these three substances together to prevent and control leaf spot disease has long been unknown. Summary of the Invention

[0008] In view of the above-mentioned prior art, the purpose of this invention is to provide a pesticide composition containing fluopyram and its application in the control of leaf spot disease.

[0009] To achieve the above objectives, the present invention adopts the following technical solution:

[0010] In a first aspect, the present invention provides a pesticide composition containing fluopyram, wherein the pesticide composition uses fluopyram and a synergistic extract as active ingredients; the synergistic extract includes at least one of cardamom extract and centipede extract.

[0011] Furthermore, the cardamom extract is prepared by the following method:

[0012] Dried cardamom fruits were washed, dried in an oven at 60℃, and pulverized to pass through a 300-mesh sieve to obtain cardamom powder. The cardamom powder was extracted in 75% v / v ethanol at a mass-to-volume ratio of 1g:3ml at room temperature for 12 hours to obtain an extract. The solids after filtering to remove the extract were added to pure water at a mass-to-volume ratio of 1g:10ml and heated rapidly initially, maintaining a gentle boil for 2 hours. After stopping heating, the mixture was allowed to stand for 40 minutes to remove the solids and aqueous phase, obtaining a secondary extract. The obtained extract and the secondary extract were combined and concentrated under reduced pressure at 60℃ to obtain cardamom extract.

[0013] Furthermore, the centipede grass extract is prepared by the following method:

[0014] Fresh whole plants of Centipede Grass during the flowering and fruiting period were collected, washed, dried in an oven at 70℃, and pulverized to pass through a 300-mesh sieve to obtain Centipede Grass powder. The Centipede Grass powder was extracted in 75% v / v ethanol at a mass-to-volume ratio of 1g:2ml at room temperature for 12 hours each time, for a total of 3 extractions. The extracts obtained from each extraction were combined, concentrated under reduced pressure at 55℃, and then dried in an oven at 75℃ to obtain Centipede Grass extract.

[0015] Furthermore, the synergistic extract is a mixture of cardamom extract and centipede extract, wherein the ratio of cardamom extract to centipede extract is (1-2)g:(1-2)g.

[0016] Furthermore, the pesticide composition further includes adjuvants, which are one or more of the following: dispersants, wetting agents, emulsifiers, solvents, cosolvents, antifreeze agents, stabilizers, preservatives, thickeners, binders, defoamers, wall materials, acid-adjusting media, alkali-adjusting media, solid inert carriers, film-forming agents, and warning colors.

[0017] Furthermore, the formulation of the pesticide composition includes suspension concentrate, emulsion, microemulsion, or powder.

[0018] Furthermore, the pesticide composition comprises the following components:

[0019] Fluopyram 100-300 parts, synergistic extract 100-300 parts, emulsifier 20-60 parts, wetting agent 10-30 parts, preservative 20-40 parts, stabilizer 1-10 parts, antifreeze 5-15 parts, defoamer 0.5-5 parts, deionized water to make up to 1000 parts.

[0020] In some embodiments, the emulsifier is at least one of alkylphenol formaldehyde resin polyoxyethylene ether, alkyl naphthalene sulfonate, or Tween-60;

[0021] The wetting agent is at least one of alkylphenol polyoxyethylene ether phosphate, alkyl sulfate or phenethylphenol polyoxyethylene ether phosphate;

[0022] The preservative is at least one of benzoic acid, isothiazolinone, or sodium benzoate;

[0023] The stabilizer is at least one of triphenyl phosphate or epichlorohydrin;

[0024] The antifreeze is at least one of propylene glycol, ethylene glycol, or glycerol;

[0025] The defoamer is at least one of organosilicon and isoamyl alcohol.

[0026] Furthermore, the emulsifier is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

[0027] Furthermore, the pesticide composition is prepared by the following method:

[0028] Take each component, mix them using a high-speed mixer, and then grind them to a particle size of 0.5-0.7 μm to obtain a pesticide composition containing fluopyram.

[0029] A second aspect of the invention provides the application of the aforementioned fluopyram-containing pesticide composition in the control of plant diseases, including leaf spot disease.

[0030] The beneficial effects of this invention are:

[0031] (1) The present invention extracts cardamom and centipede grass to obtain cardamom extract and centipede grass extract. In indoor experiments, the diameter of Alternaria apples colonies was reduced in petri dishes with cardamom extract or centipede grass extract added, indicating that cardamom extract and centipede grass extract can inhibit the growth of Alternaria apples mycelium and can be used alone or in combination to prevent and control leaf spot disease.

[0032] (2) This invention uses cardamom extract and centipede extract as synergistic extracts, combines them with fluopyram, and adds various adjuvants to prepare a fluopyram-containing pesticide composition. Field trials showed that the disease index of each experimental group was reduced compared to the control group, indicating that Alternaria appleata was inhibited. The complex group showed the highest relative efficacy, reaching 80.05%, which was superior to the fluopyram group, cardamom group, and centipede group using fluopyram, cardamom extract, or centipede alone. Therefore, the fluopyram-containing pesticide composition prepared by combining fluopyram with synergistic extracts containing cardamom extract and centipede extract can better inhibit Alternaria appleata and is suitable for pesticide development to control Alternaria appleata leaf spot disease. Detailed Implementation

[0033] It should be noted that the following detailed descriptions are illustrative and intended to provide further explanation of this application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains.

[0034] To enable those skilled in the art to better understand the technical solution of this application, the technical solution of this application will be described in detail below with reference to specific embodiments.

[0035] The test materials used in the embodiments of the present invention, unless otherwise specified, are all conventional test materials in the art and can be purchased through commercial channels.

[0036] Example 1: Preparation of Synergistic Extract

[0037] Preparation of red cardamom extract

[0038] Dried cardamom fruits were collected, washed, and dried in an oven at 60℃. The powder was then pulverized and sieved through a 300-mesh sieve to obtain cardamom powder. The cardamom powder was extracted with 75% v / v ethanol at a mass-to-volume ratio of 1g:3ml at room temperature for 12 hours to obtain an extract. The solid remaining after filtration to remove the extract was then added to pure water at a mass-to-volume ratio of 1g:10ml and heated rapidly initially, maintaining a gentle boil for 2 hours. After heating was stopped, the mixture was allowed to stand for 40 minutes to remove the solid and aqueous phase, obtaining a secondary extract. The obtained extract and the secondary extract were combined and concentrated under reduced pressure at 60℃ to obtain the cardamom extract.

[0039] Preparation of Centipede Grass Extract

[0040] Fresh whole plants of *Pteris vittata* during the flowering and fruiting period were collected, washed, dried in an oven at 70℃, and pulverized to a 300-mesh sieve to obtain *Pteris vittata* powder. The powder was extracted with 75% v / v ethanol at a mass-to-volume ratio of 1g:2ml at room temperature for 12 hours each time, for a total of 3 extractions. The extracts were combined, concentrated under reduced pressure at 55℃, and then dried in an oven at 75℃ to obtain *Pteris vittata* extract.

[0041] Example 2: Indoor Test

[0042] The apple blotch leaf spot pathogen used in this invention was collected from Yantai, Shandong Province, from apple fruits infected with the disease. The pathogen was isolated from the diseased tissue and purified. Through Koch's postulates and morphological and molecular biological identification, it was determined to be *Alternaria leuciscus*, the main pathogen causing apple blotch leaf spot. Alternaria mali Alternaria mali The obtained Alternaria applea strain was inoculated and stored on PDA medium for subsequent experiments.

[0043] Under aseptic conditions, 0.05-0.2 g (1 ml is recorded as 1 g) of cardamom extract or 0.05-0.2 g of centipede extract prepared in Example 1 were added to 100 ml of PDA medium, shaken well, and poured into 90 mm diameter petri dishes while hot. The mixture was then sterilized and set aside. Using a 5 mm diameter punch, a suitable amount of mycelial cake of the same age was drilled from the edge of a preserved Alternaria applea colony and inoculated into the center of a PDA medium containing the extract, with the mycelial side down. One mycelial cake was inoculated per dish. Three replicates were set up for each concentration. The mixture was incubated at 25°C under light for 6 days, and the colony diameter of the tested fungi was measured using the cross-crossing method. The control group (CK) without the extract was used, and the inhibition rate of mycelial growth was calculated using the following formula:

[0044] Mycelial growth inhibition rate (%) = (Control colony diameter - Treated colony diameter) / Control colony diameter × 100%

[0045] The results of mycelial growth inhibition rate are shown in Table 1.

[0046] Table 1. Inhibition rate of mycelial growth

[0047]

[0048] As shown in Table 1, compared with the control group, the diameter of Alternaria apples colonies was reduced in the petri dishes with added cardamom extract or centipede grass extract. Therefore, both cardamom extract and centipede grass extract can inhibit the growth of Alternaria apples mycelium and can be used for the development of pesticides to control Alternaria apples leaf spot disease.

[0049] Example 3: Preparation of pesticide compositions containing fluopyram

[0050] The pesticide composition containing fluopyram includes the following components: 200g fluopyram, 200g synergistic extract, 40g emulsifier, 20g wetting agent, 30g preservative, 5g stabilizer, 10g antifreeze, 1g defoamer, and deionized water to make up to 1000g.

[0051] The synergistic extract used was a mixture of cardamom extract and centipede grass extract prepared in Example 1, wherein the ratio of cardamom extract to centipede grass extract (1 ml is denoted as 1 g) was 1 g: 1 g.

[0052] The emulsifier used is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

[0053] The preparation method is as follows: each component is measured according to the formula, mixed using a high-speed mixer, and then sand-milled to a particle size of 0.600 μm to obtain a pesticide composition containing fluopyram.

[0054] Example 4: Preparation of pesticide compositions containing fluopyram

[0055] The difference from Example 3 is that in Example 4, the ratio of cardamom extract and centipede extract used in the synergistic extract is different; the ratio of cardamom extract to centipede extract (1 ml is denoted as 1 g) is 2 g: 1 g. Details are as follows:

[0056] The pesticide composition containing fluopyram includes the following components: 200g fluopyram, 200g synergistic extract, 40g emulsifier, 20g wetting agent, 30g preservative, 5g stabilizer, 10g antifreeze, 1g defoamer, and deionized water to make up to 1000g.

[0057] The synergistic extract used was a mixture of cardamom extract and centipede grass extract prepared in Example 1, wherein the ratio of cardamom extract to centipede grass extract (1 ml is denoted as 1 g) was 2 g: 1 g.

[0058] The emulsifier used is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

[0059] The preparation method is as follows: each component is measured according to the formula, mixed using a high-speed mixer, and then sand-milled to a particle size of 0.600 μm to obtain a pesticide composition containing fluopyram.

[0060] Example 5: Preparation of pesticide compositions containing fluopyram

[0061] The difference from Example 3 is that in Example 5, the ratio of cardamom extract and centipede extract used in the synergistic extract is different; the ratio of cardamom extract to centipede extract (1 ml is denoted as 1 g) is 1 g: 2 g. Details are as follows:

[0062] The pesticide composition containing fluopyram includes the following components: 200g fluopyram, 200g synergistic extract, 40g emulsifier, 20g wetting agent, 30g preservative, 5g stabilizer, 10g antifreeze, 1g defoamer, and deionized water to make up to 1000g.

[0063] The synergistic extract used was a mixture of cardamom extract and centipede grass extract prepared in Example 1, wherein the ratio of cardamom extract to centipede grass extract (1 ml is denoted as 1 g) was 1 g: 2 g.

[0064] The emulsifier used is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

[0065] The preparation method is as follows: each component is measured according to the formula, mixed using a high-speed mixer, and then sand-milled to a particle size of 0.600 μm to obtain a pesticide composition containing fluopyram.

[0066] Comparative Example 1: Preparation of Pesticide Compositions

[0067] The difference between Comparative Example 1 and Example 3 is that no extract was added. Specifically:

[0068] The pesticide composition comprises the following components: 200g fluopyram, 40g emulsifier, 20g wetting agent, 30g preservative, 5g stabilizer, 10g antifreeze, 1g defoamer, and deionized water to a total of 1000g.

[0069] The emulsifier used is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

[0070] The preparation method is as follows: measure each component according to the formula, mix them using a high-speed mixer, and then grind them to a particle size of 0.600 μm using a sand mill to obtain the pesticide composition.

[0071] Comparative Example 2: Preparation of Pesticide Compositions

[0072] The difference between Comparative Example 2 and Example 3 is that fluopyram was not added, and the synergistic extract used was cardamom extract.

[0073] The pesticide composition comprises the following components: 200g of synergistic extract, 40g of emulsifier, 20g of wetting agent, 30g of preservative, 5g of stabilizer, 10g of antifreeze, 1g of defoamer, and deionized water to a total of 1000g.

[0074] The synergistic extract used was the cardamom extract prepared in Example 1.

[0075] The emulsifier used is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

[0076] The preparation method is as follows: measure each component according to the formula, mix them using a high-speed mixer, and then grind them to a particle size of 0.600 μm using a sand mill to obtain the pesticide composition.

[0077] Comparative Example 3: Preparation of Pesticide Compositions

[0078] The difference between Comparative Example 3 and Example 3 is that fluopyram was not added, and the synergistic extract used was centipede grass extract.

[0079] The pesticide composition comprises the following components: 200g of synergistic extract, 40g of emulsifier, 20g of wetting agent, 30g of preservative, 5g of stabilizer, 10g of antifreeze, 1g of defoamer, and deionized water to a total of 1000g.

[0080] The synergistic extract used was the mixture of centipede grass extract prepared in Example 1.

[0081] The emulsifier used is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

[0082] The preparation method is as follows: measure each component according to the formula, mix them using a high-speed mixer, and then grind them to a particle size of 0.600 μm using a sand mill to obtain the pesticide composition.

[0083] Experimental example: Field trial

[0084] The test site was located in an apple orchard in Qixia District, Yantai City, Shandong Province. The tested variety was Red Fuji, the trees were 8-9 years old, and the rows were arranged in a north-south direction with a row spacing of 5m × 4m.

[0085] Experimental Methods: Field control trials were conducted using the fluopyram-containing pesticide composition prepared in Example 3 and the pesticide compositions prepared in Comparative Examples 1-3. The groups were set as follows: Complex group: the pesticide used was from Example 3, with the added synergistic extracts being cardamom extract and centipede extract prepared in Example 1; Fluopyram group: the pesticide used was from Comparative Example 1, without the addition of synergistic extracts; Cardamom group: the pesticide used was from Comparative Example 2, with the added synergistic extract being cardamom extract prepared in Example 1; Centipede group: the pesticide used was from Comparative Example 3, with the added synergistic extract being centipede extract prepared in Example 1; A control group (CK) was also set up, where the sprayed pesticide contained only the adjuvants from Example 3 (40g emulsifier, 20g wetting agent, 30g preservative, 5g stabilizer, 10g antifreeze, 1g defoamer, and deionized water to a final volume of 1000g). There were 5 treatments, with 3 parallel treatments per treatment, for a total of 15 plots. Each plot contained 2 apple trees, randomly arranged. The pesticide was applied three times consecutively on June 18, June 25, and July 2. Each time, 8L of the prepared pesticide solution was sprayed on each plot. The prepared pesticide solution was made by diluting the corresponding pesticide for each group in pure water at a volume ratio of 1ml:3000ml.

[0086] Before applying the pesticide, a baseline survey of the disease index was conducted according to the disease grading standards for each group. The efficacy was assessed 14 days after the third application. Each tree was surveyed in five directions: upper, middle, lower, east, west, south, north, and center. Twenty leaves were surveyed from each branch, and the degree of disease on each leaf was recorded. The disease index and relative control efficacy were calculated.

[0087] The disease severity grading standards are as follows: Grade 0, no lesions; Grade 1, lesions covering less than 10% of the leaf area; Grade 3, lesions covering 11% to 25% of the leaf area; Grade 5, lesions covering 26% to 40% of the leaf area; Grade 7, lesions covering 41% to 65% of the leaf area; Grade 9, lesions covering more than 65% of the leaf area.

[0088] Disease index = 100 × ∑(number of diseased leaves at a certain level × representative value of the corresponding level) / (total number of leaves surveyed × 9)

[0089] Relative efficacy = [1 - (disease index before treatment in control area × disease index after treatment in treatment area) / (disease index after treatment in control area × disease index before treatment in treatment area)] × 100%

[0090] Table 2. Field control efficacy of apple leaf spot disease

[0091]

[0092] As shown in Table 2, compared with the control group, the disease index of each experimental group was reduced, indicating that Alternaria appleata was inhibited. The complex group showed the highest relative efficacy, reaching 80.05%, which was superior to the fluopyram, cardamom, and centipede extracts used alone. Therefore, the fluopyram-containing pesticide composition prepared by combining fluopyram with synergistic extracts containing cardamom and centipede extracts can better inhibit Alternaria appleata and is suitable for pesticide development to control Alternaria appleata leaf spot disease.

[0093] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A pesticide composition containing fluopyram, characterized in that, The pesticide composition uses fluopyram and a synergistic extract as active ingredients. 1000 parts by weight of the pesticide composition contain 100-300 parts of fluopyram and 100-300 parts of the synergistic extract. The synergistic extract includes at least one of cardamom extract and centipede extract. The cardamom extract mentioned above is prepared by the following method: Dried cardamom fruits were taken, washed, and dried in an oven at 60℃. The powder was then pulverized and sieved through a 300-mesh sieve to obtain cardamom powder. The cardamom powder was extracted in 75% v / v ethanol at a mass-to-volume ratio of 1g:3ml at room temperature for 12 hours to obtain an extract. The solids after filtering to remove the extract were added to pure water at a mass-to-volume ratio of 1g:10ml and heated. Initially, the heating was rapid, and the mixture was kept at a gentle boil for 2 hours. After heating was stopped, the mixture was allowed to stand for 40 minutes to remove the solids and aqueous phase, obtaining a secondary extract. The obtained extract and the secondary extract were combined and concentrated under reduced pressure at 60℃ to obtain cardamom extract. The centipede grass extract was prepared by the following method: Fresh whole plants of Centipede Grass during the flowering and fruiting period were collected, washed, dried in an oven at 70℃, and pulverized to pass through a 300-mesh sieve to obtain Centipede Grass powder. The Centipede Grass powder was extracted in 75% v / v ethanol at a mass-to-volume ratio of 1g:2ml at room temperature for 12 hours each time, for a total of 3 extractions. The extracts obtained from each extraction were combined, concentrated under reduced pressure at 55℃, and then dried in an oven at 75℃ to obtain Centipede Grass extract. The synergistic extract is a mixture of cardamom extract and centipede grass extract, wherein the ratio of cardamom extract to centipede grass extract is (1-2)g:(1-2)g.

2. The pesticide composition containing fluopyram according to claim 1, characterized in that, The pesticide composition further includes adjuvants, which are one or more of the following: dispersants, wetting agents, emulsifiers, solvents, cosolvents, antifreeze agents, stabilizers, preservatives, thickeners, binders, defoamers, wall materials, acid-adjusting media, alkali-adjusting media, solid inert carriers, film-forming agents, and warning colors.

3. The pesticide composition containing fluopyram according to claim 1, characterized in that, The formulations of the pesticide compositions include suspensions, emulsions, microemulsions, or powders.

4. The pesticide composition containing fluopyram according to claim 1, characterized in that, The pesticide composition further includes the following components in parts by weight: 20-60 parts emulsifier, 10-30 parts wetting agent, 20-40 parts preservative, 1-10 parts stabilizer, 5-15 parts antifreeze, 0.5-5 parts defoamer, and deionized water to make up to 1000 parts.

5. The pesticide composition containing fluopyram according to claim 4, characterized in that, The emulsifier is alkylphenol formaldehyde resin polyoxyethylene ether, the wetting agent is alkylphenol polyoxyethylene ether phosphate, the preservative is benzoic acid, the stabilizer is triphenyl phosphate, the antifreeze agent is propylene glycol, and the defoamer is organosilicon.

6. The pesticide composition containing fluopyram according to claim 4, characterized in that, The pesticide composition is prepared by the following method: Take each component, mix them using a high-speed mixer, and then grind them to a particle size of 0.5-0.7 μm to obtain a pesticide composition containing fluopyram.

7. The application of the pesticide composition containing fluopyram according to any one of claims 1-6 in the control of leaf spot disease, characterized in that, The pathogen causing leaf spot disease is Alternaria appleense (…). Alternaria mali ).

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