An anti-aging composition and a skin care product containing the same

Abstract

The application relates to the cosmetic technical field, in particular to a high-efficiency anti-aging composition and a skin care product containing the same. The high-efficiency anti-aging composition is prepared from the following raw materials in parts by mass: 12-15 parts of oil-based concentrated active ingredients, 25-35 parts of base collagen liquid, 15-18 parts of ikar, 12-16 parts of TWEEN 20, and 22-25 parts of isosorbide dimethyl ether. The oil-based concentrated active ingredients include safflower seed oil, acmella oleracea flower / leaf / stem extract, Astragalus membranaceus (Fisch.) Bunge root extract, ubiquinone and vitamin E. The base collagen liquid includes type XVII collagen, type VII collagen and type IV collagen. The composition can effectively reduce skin wrinkles, improve skin tightness and reduce skin sagging in a long term, and prevent skin aging, and realizes long-term anti-aging from epidermis to dermis.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of cosmetics, in particular to an anti-aging composition and a skin care product containing the same. BACKGROUND

[0002] The occurrence of skin aging is due to the synergistic effect of endogenous aging and exogenous stimulation, and its performance is directly related to the structural and functional degradation of the epidermis, dermis and junctional layer. At the endogenous level, with age, the activity of fibroblasts decreases, leading to loose junctional layer structure, weakened mechanical connection between epidermis and dermis, and decreased skin resistance to tension; at the same time, the imbalance of free radical metabolism leads to collagen crosslinking or breaking, and the collapse of the dermal support network, resulting in decreased skin elasticity and sagging. Among the exogenous factors, inflammation factors induced by ultraviolet light accelerate collagen degradation, and abnormal release of acetylcholine at the neuromuscular junction causes muscle overcontraction, first forming dynamic wrinkles, and then static wrinkles due to irreversible damage to collagen. In addition, the epidermal barrier is damaged due to the oxidation of the lipid bilayer by free radicals, and the water retention capacity is decreased, which, combined with delayed keratin metabolism, leads to dry and dull skin, forming a chain reaction from structural damage to functional decline. The main appearance is sagging, loss of elasticity, pigmentation, dull complexion, enlarged pores, and deepening of wrinkles.

[0003] The existing anti-aging technology has significant defects. First, the efficacy dimension is single, such as peony root extract focusing on antioxidant, retinol promoting skin keratinocyte differentiation, all of which are difficult to comprehensively resist multiple-pathway aging mechanisms such as photoaging and glycation; in addition, some products add chemical ingredients which have certain toxic and side effects on the human body, and long-term overuse can damage the skin barrier function, cause sensitive skin, and improve the dynamic and static wrinkles, that is, the immediate anti-wrinkle ingredients only temporarily relieve muscle contraction, ignore the repair of the DEJ layer, making it difficult for anti-wrinkle ingredients to integrate into the dermal network, resulting in a loss of support for the epidermis and blocked nutrient transmission in the dermis, which greatly reduces the repair effect, making anti-wrinkle products either slow-acting or not long-lasting, resulting in poor anti-aging effect. SUMMARY

[0004] In view of the problem that the existing skin care products cannot effectively reduce skin wrinkles, improve skin firmness and reduce skin sagging for a long time, and prevent skin aging, the present application provides an anti-aging composition and a skin care product containing the same.

[0005] In a first aspect, the present application provides an anti-aging composition, which adopts the following technical solution:

[0006] An anti-aging composition, comprising the following raw materials in parts by mass: oil-based concentrated active ingredient 12-15 parts, base collagen solution 25-35 parts, ectoine 15-18 parts, TWEEN 20 12-16 parts, isosorbide dimethyl ether 22-25 parts, the oil-based concentrated active ingredient being safflower seed oil, acmella oleracea flower / leaf / stem extract, Astragalus membranaceus (Fisch.) Bunge root extract, ubiquinone, vitamin E; the base collagen solution comprising collagen type XVII, collagen type VII, collagen type IV.

[0007] The anti-aging composition of the present application realizes the effects of long-term reducing wrinkles, improving tightness and reducing sagging through the interaction of multiple components in the epidermis, the epidermis-dermis junction layer (DEJ layer) and the dermis. The epidermis, as the outermost barrier of the skin, its connection stability with the dermis directly determines the skin's anti-pulling ability and nutrient exchange efficiency. The base collagen solution contains collagen type XVII, collagen type VII and collagen type IV, which interact together to strengthen the basic support of the epidermis, DEJ layer and dermis, prevent the epidermis from relaxing due to insufficient support of the basal layer, and thus improve deep static wrinkles caused by sagging of facial contour due to insufficient elasticity of the epidermis; collagen type XVII, as a transmembrane protein, can combine with integrin and load into a hemidesmosome. The hemidesmosome, as an anchoring structure, is tightly combined with the transmembrane region of the laminin cells and embedded in the cell membrane of the epidermal basal cells, strengthening the tight connection between the epidermis and the dermis. The extracellular region extends a specific binding site, the alpha-helix region, which is complementary in spatial structure to the beta-fold region of the NC1 terminal domain of collagen type VII, so that they are embedded and precisely docked. The interaction of the peptide chains of the two and integrin ensures that the epidermis will not separate from the dermis due to mechanical pulling; collagen type VII, as a mechanical transmission fiber, has a long-chain structure that spans the DEJ layer, and the NC2 end is embedded in the basement membrane grid formed by collagen type IV, uniformly transmitting the dynamic tension received by the epidermis to the dermis, avoiding collagen rupture caused by local stress concentration; collagen type IV is intertwined with laminin and other components into a dense basement membrane grid through a triple helix structure, providing a stable attachment fulcrum for collagen type VII and regulating the transportation of growth factors secreted by fibroblasts in the dermis to the epidermis through the grid pores, ensuring the proliferation and differentiation of epidermal keratinocytes and maintaining the integrity of the epidermal barrier. The interaction of the three makes the DEJ layer structure tight, strengthens the connection and support between the epidermis and the dermis, and long-term slows down the formation of wrinkles and improves skin sagging.

[0008] On this basis, the oil-based concentrated active ingredient of the extract of Gynura divaricata flower / leaf / stem can block the voltage-gated sodium ion channel at the neuromuscular junction, reduce the release of acetylcholine, immediately relieve the dynamic tension caused by muscle overcontraction, reduce the mechanical pull on the DEJ layer, and create a low-damage environment for the three types of repair collagen in the basement collagen solution; the extract of Astragalus membranaceus root can directly stimulate the fibroblasts in the dermis layer, promote the synthesis of type I collagen, and enhance the mechanical support of the dermis, together with the three types of collagen in the basement collagen solution to enhance the repair of the DEJ layer and reduce the stress load on the DEJ layer, and the stability of the DEJ layer can effectively transmit the support of the dermis to the epidermis, thereby improving skin sagging and static wrinkles; the antioxidant system composed of ubiquinone and vitamin E can specifically remove active oxygen free radicals generated by external stimuli such as ultraviolet rays, reduce the oxidative damage of sulfhydryl groups of type XVII collagen, peptide bonds of type VII collagen, and hydroxyl groups of type IV collagen, and protect the structural integrity of the DEJ layer.

[0009] Ectoine can inhibit the release of inflammatory factors such as tumor necrosis factor-α and interleukin-6, reduce the production of matrix metalloproteinase, and prevent its activity of degrading type VII collagen, thereby avoiding the enzymatic destruction of collagen and enhancing the stability of antioxidant substances in the oil-based component, in addition, TWEEN 20 and isosorbide dimethyl ether as a penetration system can ensure that the oil-based concentrated active ingredient penetrates the stratum corneum of the epidermis, the basement collagen solution reaches the DEJ layer and the dermis, realizes the precise cooperation of epidermal barrier maintenance, DEJ layer structure repair, and dermal support enhancement, and finally realizes long-term anti-aging from the epidermis to the dermis, effectively reduces wrinkles, improves tightness, and improves skin sagging.

[0010] The mass ratio of the oil-based concentrated active ingredient, the basement collagen solution, and ectoine is 1: (1.5-2): (0.8-1.5).

[0011] Based on the above effects of the effective components, the inventors further explored the effects of the proportions of the effective components. The oil-based concentrated active ingredients create a stable environment for the DEJ layer and dermal collagen repair of the basal collagen solution by instant soothing dynamic lines and reducing oxidative damage; help the basal collagen solution to rebuild the epidermis-dermis connection and support structure, enhance the structural basis of the effect of the oil-based component; and inhibit the degradation of the two by inflammatory factors, prolong the action time, achieve instant relief of dynamic lines, and achieve long-term beneficial effects of static line reduction, skin tightening and sagging improvement by enhancing the structural support of the DEJ layer and dermis. Excessive basal collagen solution will make the instant regulating ability of the oil-based component relatively insufficient, slow down the soothing of dynamic lines, and increase the mechanical tension faced by the collagen repair, resulting in relatively slow repair of fine lines; insufficient collagen supply will result in insufficient structural support for the improved state of the oil-based component, and short maintenance period. When the amount of icodextrin is insufficient, the inhibitory effect on inflammatory factors is weakened, the antioxidant loss of the oil-based component is accelerated, and the improvement of skin darkening is slowed down.

[0012] The mass ratio of the collagen XVII, collagen VII and collagen IV is 1: (1.5-2): (2.4-3.2).

[0013] The inventors found that the collagen XVII, collagen VII and collagen IV can efficiently strengthen and achieve the structural integrity and mechanical stability of the epidermis, DEJ layer and dermis at the above mass ratio. It is believed that if the amount of collagen VII is too much, the non-collagen domains NC1 at the end of the long-chain structure of collagen VII will cross-link to form abnormal fiber bundles, block the pores of the collagen IV grid, hinder the transmission of nutrients from the dermis to the epidermis, cause the metabolic rate of the epidermis to decrease, the improvement of skin dullness to be not obvious, the barrier function to be weakened, and the short-term anti-wrinkle effect to be poor; if the amount is too little, the connection strength is insufficient, the anchoring signal transmission of collagen XVII cannot be effectively transmitted to the basement membrane, the dynamic tension buffering capacity is reduced, the epidermis is easily separated from the dermis due to external traction, the improvement of skin sagging is slow, and the anti-aging effect is poor. If the amount of collagen IV is too little, the support frame will be weak, the tension transmission of collagen VII will lack a stable fulcrum, the overall anti-pulling performance of the connection layer will be reduced, and the repair efficiency of deep static lines will be affected.

[0014] The anti-aging composition further comprises 5-8 parts of an anti-aging component, which comprises one or more of acetyl hexapeptide-8, acetyl hexapeptide-1, ascorbyl tetraisopalmitate, bovine sirtuins, vitamin C ethyl ether, alfalfa extract, cornflower extract, helichrysum extract, chicory root extract, and inca berry oil.

[0015] Preferably, the anti-aging component is chicory root extract and inca berry oil at a mass ratio of 1: (4-6).

[0016] By adopting the above technical scheme, the chicory root extract can stimulate the activity of fibroblasts, promote the synthesis of endogenous collagen, further strengthen the dermal support, and enhance the skin elasticity. On this basis, the inca oil is used in cooperation, the inca oil contains rich unsaturated fatty acids, repairs the epidermal lipid barrier, reduces water loss and improves dullness, and improves the epidermal luster. At the same time, the inca oil has the fat-soluble quality of wrapping the chicory root extract penetrating the dermis, strengthening the dermal support, and improving the tightness and elasticity. Based on different mechanisms, the two can effectively improve the skin elasticity and maintain the tightness. In addition, the anti-aging component and the safflower seed oil synergistically act. On the one hand, the w3 and w6 fatty acids in the safflower seed oil regulate inflammatory factors and reduce the damage of L-6 and TNF-alpha to collagen, so as to provide a more stable environment for the chicory root extract to stimulate fibroblasts to synthesize collagen, improve the tightness and elasticity. On the other hand, the linoleic acid in the safflower seed oil and the unsaturated fatty acid in the inca oil jointly participate in the stabilization of the lipid bilayer, enhance the water-locking capacity, and reduce the dullness caused by dryness. If the content of the inca oil is too low, the repair of the epidermal lipid barrier is insufficient, the water-locking capacity of the skin is weakened, the improvement effect of the dullness is reduced, the transdermal efficiency of the safflower seed oil and the chicory root extract is affected, the regulation of inflammatory factors is reduced, and the overall repair efficiency of elasticity and tightness is reduced.

[0017] In a second aspect, the present application provides a skin care product, which is one of an anti-aging serum and a skin care cream. The skin care product comprises the anti-aging composition provided in the first aspect.

[0018] Further, the anti-aging serum comprises the anti-aging composition, and the mass percentage content of the anti-aging composition is 2-10%.

[0019] The anti-aging serum further comprises the following raw materials made in the following mass percentages: 1,3-butanediol 3-10%, TR-20 1-0.3%, arginine 0.1-0.3%, 1,2-hexanediol 0.5-0.8%, p-hydroxyacetophenone 0.3-0.6%, and the balance is water.

[0020] In summary, the present application has the following beneficial effects:

[0021] 1. The anti-aging composition of this application achieves long-term wrinkle reduction, improved firmness, and reduced sagging through the interaction of multiple components in the epidermis, epidermal-dermal junction (DEJ layer), and dermis. First, the interaction of type XVII, type VII, and type IV collagen contained in the base collagen solution strengthens the basic support of the epidermis, DEJ layer, and dermis. The concentrated active ingredients in the oil base instantly soothe dynamic wrinkles and reduce oxidative damage, creating a stable structural foundation for the base collagen solution to repair the DEJ layer and dermal collagen. Ectoin inhibits the degradation of both by inflammatory factors, prolonging its duration of action. This achieves immediate relief of dynamic wrinkles and, by enhancing the structural support of the DEJ layer and dermis, long-term beneficial effects such as reduction of static wrinkles, improved firmness, and reduced sagging.

[0022] 2. By using chicory root extract to help rebuild the epidermal-dermal connection and support structure of the base collagen solution, and enhancing the activity of fibroblasts by the oil-based components, promoting endogenous collagen synthesis, and further strengthening dermal support and enhancing skin elasticity, the addition of Inca Inchi oil, rich in unsaturated fatty acids, repairs the epidermal lipid barrier, reduces moisture loss, improves dullness, and enhances epidermal radiance. At the same time, the fat-soluble properties of Inca Inchi oil encapsulate the chicory root extract to penetrate the dermis, strengthen dermal support, and improve firmness and elasticity. Detailed Implementation

[0023] The present application will be further described in detail below with reference to the embodiments.

[0024] Some of the raw materials used in the preparation examples and embodiments: the oil-based concentrated active ingredient, commercially known as LIFT Oléoactif, was purchased from HALLSTAR, and its components are safflower seed oil, golden button flower / leaf / stem extract, Astragalus membranaceus root extract, ubiquinone, and vitamin E; ectoine was purchased from Guangzhou Shengrui Chemical Technology Co., Ltd.; TWEEN 20 was purchased from Heda; type XVII collagen was prepared as a 100 g / L solution of type XVII collagen, purchased from Jiangsu Jinpu Nuoan Biotechnology Co., Ltd.; type VII collagen was prepared as a solution of type VII collagen, purchased from Shanghai Yaji Biotechnology Co., Ltd.; type IV collagen was prepared as a solution of type IV collagen, both purchased from Shanghai Yuanmu Biotechnology Co., Ltd.; chicory root extract was purchased from Shaanxi Haochen Biotechnology Co., Ltd.; Inca Inchi oil was purchased from Xuzhou Yihuiyang New Materials Co., Ltd.; TR-2 is carbomer; unless otherwise specified, all raw materials used in the embodiments and comparative examples are conventional products that can be purchased commercially. Example 1

[0025] An anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, ectoine 15 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII, and collagen type IV in a mass ratio of 1:2:3;

[0026] TWEEN 20, the base collagen liquid, and ectoine are mixed in proportion, dissolved by stirring at 45°C, isosorbide dimethyl ether is added and stirred uniformly, the oil-based concentrated active ingredient is added, and the temperature is lowered to room temperature after high-speed stirring for 5 min, to obtain the anti-aging composition. Example 2

[0027] An anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen liquid 33 parts, ectoine 12 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII, and collagen type IV in a mass ratio of 1:2:3;

[0028] TWEEN 20, the base collagen liquid, and ectoine are mixed in proportion, dissolved by stirring at 45°C, isosorbide dimethyl ether is added and stirred uniformly, the oil-based concentrated active ingredient is added, and the temperature is lowered to room temperature after high-speed stirring for 5 min, to obtain the anti-aging composition. Example 3

[0029] An anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen liquid 25 parts, ectoine 20 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII, and collagen type IV in a mass ratio of 1:2:3;

[0030] TWEEN 20, the base collagen liquid, and ectoine are mixed in proportion, dissolved by stirring at 45°C, isosorbide dimethyl ether is added and stirred uniformly, the oil-based concentrated active ingredient is added, and the temperature is lowered to room temperature after high-speed stirring for 5 min, to obtain the anti-aging composition. Example 4

[0031] An anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 20 parts, base collagen liquid 30 parts, ectoine 10 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII, and collagen type IV in a mass ratio of 1:2:3;

[0032] The TWEEN 20, the base collagen liquid and the ikkodin are mixed in proportion, dissolved by stirring at 45°C, uniformly stirred by adding isosorbide dimethyl ether, and the oil-based concentrated active ingredient is added. After high-speed stirring for 5 min, the temperature is lowered to room temperature to obtain the anti-aging composition. Example 5

[0033] An anti-aging composition is made from the following mass parts of raw materials: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, ikkodin 15 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII and collagen type IV in a mass ratio of 1:2.5:2.5;

[0034] The TWEEN 20, the base collagen liquid and the ikkodin are mixed in proportion, dissolved by stirring at 45°C, uniformly stirred by adding isosorbide dimethyl ether, and the oil-based concentrated active ingredient is added. After high-speed stirring for 5 min, the temperature is lowered to room temperature to obtain the anti-aging composition. Example 6

[0035] An anti-aging composition is made from the following mass parts of raw materials: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, ikkodin 15 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII and collagen type IV in a mass ratio of 1:2.5:2.5;

[0036] The TWEEN 20, the base collagen liquid and the ikkodin are mixed in proportion, dissolved by stirring at 45°C, uniformly stirred by adding isosorbide dimethyl ether, and the oil-based concentrated active ingredient is added. After high-speed stirring for 5 min, the temperature is lowered to room temperature to obtain the anti-aging composition. Example 7

[0037] An anti-aging composition is made from the following mass parts of raw materials: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, ikkodin 15 parts, anti-aging component 8 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII and collagen type IV in a mass ratio of 1:2:3; the anti-aging component is chicory root extract and acerola oil in a mass ratio of 1:6;

[0038] The TWEEN 20, the base collagen liquid and the ikkodin are mixed in proportion, dissolved by stirring at 45°C, uniformly stirred by adding isosorbide dimethyl ether, and the oil-based concentrated active ingredient is added. After high-speed stirring for 5 min, the temperature is lowered to room temperature to obtain the anti-aging composition. Example 8

[0039] An anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, ectoine 15 parts, anti-aging component 8 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII, collagen type IV in a mass ratio of 1:2:3; the anti-aging component is chicory root extract and Sacha Inchi oil in a mass ratio of 1:3;

[0040] TWEEN 20, base collagen liquid, and ectoine are mixed in proportion, dissolved by stirring at 45°C, isosorbide dimethyl ether is added and stirred uniformly, the oil-based concentrated active ingredient is added, the anti-aging component is stirred at high speed for 5 min, and then cooled to room temperature to obtain the anti-aging composition. Example 9

[0041] An anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, ectoine 15 parts, chicory root extract 8 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts, the oil-based concentrated active ingredient is safflower seed oil, acmella oleracea flower / leaf / stem extract, Astragalus membranaceus root extract, ubiquinone, and vitamin E; the base collagen liquid is collagen type XVII, collagen type VII, and collagen type IV in a mass ratio of 1:2:3;

[0042] TWEEN 20, base collagen liquid, and ectoine are mixed in proportion, dissolved by stirring at 45°C, isosorbide dimethyl ether is added and stirred uniformly, the oil-based concentrated active ingredient is added, the anti-aging component is stirred at high speed for 5 min, and then cooled to room temperature to obtain the anti-aging composition. Example 10

[0043] An anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, ectoine 15 parts, Sacha Inchi oil 8 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts, the oil-based concentrated active ingredient is safflower seed oil, acmella oleracea flower / leaf / stem extract, Astragalus membranaceus root extract, ubiquinone, and vitamin E; the base collagen liquid is collagen type XVII, collagen type VII, and collagen type IV in a mass ratio of 1:2:3;

[0044] TWEEN 20, base collagen liquid, and ectoine are mixed in proportion, dissolved by stirring at 45°C, isosorbide dimethyl ether is added and stirred uniformly, the oil-based concentrated active ingredient is added, the anti-aging component is stirred at high speed for 5 min, and then cooled to room temperature to obtain the anti-aging composition. Example 11

[0045] An anti-aging serum is prepared from the following ingredients in the indicated amounts: 1,3-butanediol 5%, TR-2 0.2%, arginine 0.2%, 1,2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, the anti-aging composition of Example 1 10%. The balance is water.

[0046] Half of the water, butanediol, TR-2, 1,2-hexanediol, and p-hydroxyacetophenone are added in proportion and heated to 80°C with stirring to disperse them uniformly. Then the solution of arginine and the other half of the water is added, and the temperature is lowered to 40°C. The anti-aging composition of Example 1 is added and stirred to obtain an anti-aging serum. Example 12

[0047] The difference between this example and Example 11 is that the anti-aging composition of Example 2 is used in place of the anti-aging composition of Example 1. Example 13

[0048] The difference between this example and Example 11 is that the anti-aging composition of Example 3 is used in place of the anti-aging composition of Example 1. Example 14

[0049] The difference between this example and Example 11 is that the anti-aging composition of Example 4 is used in place of the anti-aging composition of Example 1. Example 15

[0050] The difference between this example and Example 11 is that the anti-aging composition of Example 5 is used in place of the anti-aging composition of Example 1. Example 16

[0051] The difference between this example and Example 11 is that the anti-aging composition of Example 6 is used in place of the anti-aging composition of Example 1. Example 17

[0052] The difference between this example and Example 11 is that the anti-aging composition of Example 7 is used in place of the anti-aging composition of Example 1. Example 18

[0053] The difference between this example and Example 11 is that the anti-aging composition of Example 8 is used in place of the anti-aging composition of Example 1. Example 19

[0054] The difference between this example and Example 11 is that the anti-aging composition of Example 9 is used in place of the anti-aging composition of Example 1. Example 20

[0055] The difference between this example and Example 11 is that the high-efficiency anti-aging composition of Example 10 is used to replace the anti-aging composition of Example 1 in equal amount.

[0056] Comparative Example 1

[0057] An anti-aging essence is prepared from the following raw materials in mass percentage: 1,3-butanediol 5%, TR-2 0.2%, arginine 0.2%, 1,2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, anti-aging composition 10%, and the balance is water. The anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen solution 30 parts, ikkduoin 15 parts, TWEEN 20 15 parts, and isosorbide dimethyl ether 25 parts; the base collagen solution is type XVII collagen and type IV collagen in a mass ratio of 1:5.

[0058] Preparation of the anti-aging composition: mix TWEEN 20, the base collagen solution, and ikkduoin in proportion, dissolve by stirring at 45°C, add isosorbide dimethyl ether and stir uniformly, add the oil-based concentrated active ingredient, and then cool to room temperature after stirring at high speed for 5 min to obtain the anti-aging composition.

[0059] Preparation of the anti-aging essence: add half of the water, butanediol, TR-2, 1,2-hexanediol, and p-hydroxyacetophenone in proportion and heat to 80°C to stir and disperse uniformly, then add the solution of arginine and the other half of the water, cool to 40°C, add the anti-aging composition and stir uniformly to obtain the anti-aging essence.

[0060] Comparative Example 2

[0061] The difference between this comparative example and Comparative Example 1 is that the base collagen solution is type XVII collagen and type VII collagen in a mass ratio of 1:5.

[0062] Comparative Example 3

[0063] The difference between this comparative example and Comparative Example 1 is that the base collagen solution is type VII collagen and type IV collagen in a mass ratio of 1:1.

[0064] Comparative Example 4

[0065] The difference between this comparative example and Comparative Example 1 is that the base collagen solution is type XVII collagen.

[0066] Comparative Example 5

[0067] The difference between this comparative example and Comparative Example 1 is that the base collagen solution is type VII collagen.

[0068] Comparative Example 6

[0069] The difference between this comparative example and Comparative Example 1 is that the base collagen solution is type IV collagen.

[0070] Comparative Example 7

[0071] An anti-aging serum is prepared from the following raw materials in mass percentage: 1,3-butanediol 5%, TR-2 0.2%, arginine 0.2%, 1,2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, anti-aging composition 10%, and the balance being water. The anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, base collagen liquid 30 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts; the base collagen liquid is collagen type XVII, collagen type VII, and collagen type IV in a mass ratio of 1:2:3;

[0072] Preparation of the anti-aging composition: mix TWEEN 20 and the base collagen liquid in proportion, dissolve by stirring at 45°C, add isosorbide dimethyl ether and stir until uniform, add the oil-based concentrated active ingredient, stir at high speed for 5 min, then cool to room temperature to obtain the anti-aging composition.

[0073] Preparation of the anti-aging serum: add half of the water, butanediol, TR-2, 1,2-hexanediol, and p-hydroxyacetophenone in proportion and stir to disperse uniformly at 80°C, then add the solution of arginine and the other half of the water, cool to 40°C, add the anti-aging composition and stir until uniform to obtain the anti-aging serum.

[0074] Comparative Example 8

[0075] An anti-aging serum is prepared from the following raw materials in mass percentage: 1,3-butanediol 5%, TR-2 0.2%, arginine 0.2%, 1,2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, anti-aging composition 10%, and the balance being water. The anti-aging composition is prepared from the following raw materials in mass parts: oil-based concentrated active ingredient 15 parts, ikkduin 15 parts, TWEEN 20 15 parts, isosorbide dimethyl ether 25 parts;

[0076] Preparation of the anti-aging composition: mix TWEEN 20 and ikkduin in proportion, dissolve by stirring at 45°C, add isosorbide dimethyl ether and stir until uniform, add the oil-based concentrated active ingredient, stir at high speed for 5 min, then cool to room temperature to obtain the anti-aging composition.

[0077] Preparation of the anti-aging serum: add half of the water, butanediol, TR-2, 1,2-hexanediol, and p-hydroxyacetophenone in proportion and stir to disperse uniformly at 80°C, then add the solution of arginine and the other half of the water, cool to 40°C, add the anti-aging composition and stir until uniform to obtain the anti-aging serum.

[0078] Comparative Example 9

[0079] An anti-aging essence is prepared from the following raw materials in the following mass percentages: 1,3-butanediol 5%, TR-2 0.2%, arginine 0.2%, 1,2-hexanediol 0.5%, p-hydroxyacetophenone 0.5%, and the balance being water. The anti-aging composition 10% is prepared from the following raw materials in the following mass parts: base collagen liquid 30 parts, ikkduin 15 parts, TWEEN 20 15 parts, and isosorbide dimethyl ether 25 parts, and the base collagen liquid is type XVII collagen, type VII collagen, and type IV collagen in a mass ratio of 1:2:3;

[0080] Preparation of the anti-aging composition: the TWEEN 20, base collagen liquid, and ikkduin are mixed in proportion, dissolved by stirring at 45°C, and then the isosorbide dimethyl ether is added and stirred uniformly. After high-speed stirring for 5 min, the temperature is lowered to room temperature to obtain the anti-aging composition.

[0081] Preparation of the anti-aging essence: half of the water, butanediol, TR-2, 1,2-hexanediol, and p-hydroxyacetophenone are added in sequence and heated to 80°C and stirred to disperse uniformly. Then, the solution of arginine and the other half of the water is added, the temperature is lowered to 40°C, the anti-aging composition is added and stirred uniformly, and the anti-aging essence is obtained.

[0082] Performance testing of the anti-aging essence prepared in the examples and comparative examples is performed using the following methods:

[0083] Number of test subjects: 57, divided into 19 groups, 3 people in each group, and the skin conditions of the groups have no significant difference, and the age is between 45-55 years old; the subjects wash their faces before the test, and then wait for 30 min in a constant temperature and humidity environment (temperature 21-23°C, humidity 55-65%) before the test;

[0084] a. Anti-wrinkle and anti-aging effect test: the wrinkle reduction effect is tested using a human skin rapid optical imaging system (PRIMOS, Germany), and each group of subjects applies the products of examples 11-20 and comparative examples 1-9 to the face, uses them once a day, continuously uses them for 14 days, and then tests the facial wrinkles before use, after 3 days of use, and after 14 days of use after washing the face.

[0085] b. Skin elasticity: a skin elasticity tester Cutometer MPA580 (Courage+Khazaka Company, Germany) is used to test the skin condition before use and after 14 days, and the test site is the cheek. The probe is repeatedly measured 3 times in the same test area, and the average value is taken. The test parameters are R2 (the ratio of the skin rebound amount Ua without negative pressure to the maximum stretching amount Uf with negative pressure), and the closer R2 is to 1, the better the skin elasticity is. The average change value of R2 = 14-day R2 value-0-day R2 value, and the average change rate of R2 = average change value of R2 / 0-day R2 value. The specific test results of skin elasticity are shown in Table 1.

[0086] Table 1 performance test results

[0087]

[0088] As can be seen from Table 1, compared with Examples 11-14 and Comparative Examples 7-9, the anti-wrinkle repair effect and skin elasticity change of the essence prepared in Example 11 are better than those of Examples 12-14 and Comparative Examples 7-9. It is analyzed that the oil-based concentrated active ingredient is wrapped by the lipid-soluble property of the ingredient to penetrate the dermis, strengthen the dermal support, improve the skin elasticity, and repair the epidermal lipid barrier, reduce water loss, and improve the gloss of the epidermis, thereby improving the bioavailability of the oil-based concentrated active ingredient. The combination of the inca oil and the chicory root extract as the anti-wrinkle component shows a synergistic effect.

[0089] As can be seen from Table 1, compared with Examples 11-14 and Comparative Examples 7-9, the anti-wrinkle repair effect and skin elasticity change of the essence prepared in Example 11 are better than those of Examples 12-14 and Comparative Examples 7-9. It is analyzed that the oil-based concentrated active ingredient is wrapped by the lipid-soluble property of the ingredient to penetrate the dermis, strengthen the dermal support, improve the skin elasticity, and repair the epidermal lipid barrier, reduce water loss, and improve the gloss of the epidermis, thereby improving the bioavailability of the oil-based concentrated active ingredient. The combination of the inca oil and the chicory root extract as the anti-wrinkle component shows a synergistic effect.

[0090] As can be seen from Table 1, compared with Examples 11-14 and Comparative Examples 7-9, the anti-wrinkle repair effect and skin elasticity change of the essence prepared in Example 11 are better than those of Examples 12-14 and Comparative Examples 7-9. It is analyzed that the oil-based concentrated active ingredient is wrapped by the lipid-soluble property of the ingredient to penetrate the dermis, strengthen the dermal support, improve the skin elasticity, and repair the epidermal lipid barrier, reduce water loss, and improve the gloss of the epidermis, thereby improving the bioavailability of the oil-based concentrated active ingredient. The combination of the inca oil and the chicory root extract as the anti-wrinkle component shows a synergistic effect.

[0091] The above are preferred embodiments of the present application, but do not limit the protection scope of the present application, so: any equivalent changes made in structure, shape, principle, etc. according to the present application should be covered within the protection scope of the present application.

Claims

1. An anti-aging composition, characterized in that: The anti-aging composition is prepared from the following raw materials in parts by mass: oil-based concentrated active ingredient 12-15 parts, base collagen solution 25-35 parts, ectoine 15-18 parts, TWEEN 20 12-16 parts, isosorbide dimethyl ether 22-25 parts; the oil-based concentrated active ingredient comprises safflower seed oil, acmella oleracea flower / leaf / stem extract, Astragalus membranaceus root extract, ubiquinone, vitamin E; the base collagen solution is type XVII collagen, type VII collagen, and type IV collagen at a mass ratio of 1:(1.5-2):(2.4-3.2); The anti-aging composition further comprises an anti-aging component 5-8 parts. The anti-aging component is acer root extract and Sacha Inchi oil at a mass ratio of 1: (4-6).

2. The anti-aging composition according to claim 1, characterized by: The anti-aging component is acer root extract and Sacha Inchi oil at a mass ratio of 1:

6.

3. A skin care product, characterized by: The skin care product is one of an anti-aging serum and a skin care cream.

4. The skin care product of claim 3, wherein: The skin care product is an anti-aging serum, and the mass percentage content of the anti-aging composition in the anti-aging serum is 2-10%.

5. The skin care product of claim 4, wherein, The anti-aging serum further comprises the following raw materials in parts by mass: 1,3-butanediol 3-10%, TR-2 0.1-0.3%, arginine 0.1-0.3%, 1,2-hexanediol 0.5-0.8%, p-hydroxyacetophenone 0.3-0.6%, and the balance is water.

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