Preparation method and application of 2-amino-3-chloro-5-trifluoromethylpyridine

By using 2,3,6-trichloro-5-trifluoromethylpyridine as a raw material, the efficient preparation of 2-amino-3-chloro-5-trifluoromethylpyridine was achieved through microwave amination and catalytic hydrogenation dechlorination reaction. This solves the problems of high raw material cost and heavy environmental burden in the existing technology and provides a high-purity, high-yield bactericide intermediate.

CN120865074APending Publication Date: 2025-10-31SHANDONG HUIMENG BIO TECH CO LTD
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Patent Information

Application Number
CN202510735551.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-04
Publication Date
2025-10-31

AI Technical Summary

Technical Problem

Existing synthesis technologies for 2-amino-3-chloro-5-trifluoromethylpyridine suffer from high raw material costs, complex processes, heavy environmental burden, low product yield, unsatisfactory purity, and the generation of large amounts of solid waste and highly acidic byproducts by traditional metal reduction systems, making large-scale production difficult.

Method used

Using 2,3,6-trichloro-5-trifluoromethylpyridine as raw material, a two-step reaction of microwave amination and catalytic hydrogenation dechlorination is achieved. By selectively activating chemical bonds with microwave energy, combined with a composite catalyst system and an acid-binding agent, efficient amination and dechlorination reactions are realized, simplifying the process and reducing costs.

Benefits of technology

It significantly reduces raw material procurement costs, shortens reaction cycles, improves product purity and yield, reduces by-product generation, meets green chemistry requirements, and provides a highly efficient and reliable bactericide intermediate.

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Abstract

The invention relates to the technical field of biological medicine manufacturing, in particular to a preparation method of 2-amino-3-chloro-5-trifluoromethylpyridine and application of the 2-amino-3-chloro-5-trifluoromethylpyridine. The invention relates to a preparation method of 2-amino-3-chloro-5-trifluoromethylpyridine, which comprises the following steps: S1, by taking 2, 3, 6-trichloro-5-trifluoromethylpyridine as a raw material, carrying out microwave amination reaction in the presence of an aminating agent and a solvent A to generate 2-amino-3, 6-dichloro-5-trifluoromethylpyridine; s2, the 2-amino-3, 6-dichloro-5-trifluoromethylpyridine obtained in the step S1 is subjected to a catalytic hydrodechlorination reaction in the presence of a solvent B, a catalyst, an acid binding agent and hydrogen, and the 2-amino-3-chloro-5-trifluoromethylpyridine is obtained. According to the method, the raw material purchasing cost is effectively reduced, the overall reaction period is shortened, and the generation amount of byproducts is reduced. The reaction process does not need to use a strong corrosive reagent, and the process route better meets the green chemical requirement.
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