Smelling and transdermal double-acting smoke-control compound acupoint massage essential oil and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a sniffing and transdermal double-acting smoke-control compound acupoint massage essential oil and a preparation method thereof.The essential oil is prepared by taking cinnamon essential oil as a monarch drug, chamomile essential oil as a ministerial drug, peppermint essential oil, limonene, linalool, vanillin and methyl cinnamate as adjuvant drugs and jojoba oil as a conductant drug through a one-step method. Vitamin E, a rosemary extract, cineole and rose essential oil are added as auxiliary components. By means of scientific compatibility and process optimization, the core defects of existing essential oil type smoke control products are overcome, all the components cooperate to inhibit the activity of monoamine oxidase and adjust the dopamine level, and the rapid effect taking and long-acting smoke control effect is achieved in combination with the traditional Chinese medicine acupoint massage and sniffing double absorption ways. The invention solves the problems of poor user experience, poor stability, slow effect, insufficient pertinence and the like of the existing smoking control essential oil, has the advantages of good smoking control effect, convenience in use, wide applicable crowd, high user acceptability and the like, and is beneficial to improving the success rate of smoking cessation.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a kind of compound acupoint massage essential oil for smelling and transdermal dual action smoke control and a preparation method thereof. BACKGROUND

[0002] Smoking is a globally recognized health hazard, and the development of smoking control products has always been a hot topic in the industry. Existing research results show that the effect of conventional smoking control and smoking cessation products is often difficult to sustain, because the smoking cessation process is a comprehensive and multi-faceted behavior correction, which not only needs to resist the drug dependence of nicotine, but also needs to overcome the psychological dependence of smoking, and needs to resist various temptation factors in the environment. Most of the existing self-use products have obvious negative feelings, low acceptance and unwillingness to use continuously when used alone, resulting in poor effect sustainability and high relapse rate. The drugs used in smoking cessation clinics are mostly bupropion hydrochloride and nicotine patches, which have good short-term effect but are also difficult to sustain for a long time. For example, KR101126279B1 discloses a kind of mixed essential oil composition and a method for preparing a smoking cessation aid using the composition, the mixed essential oil composition contains 25-35% bergamot oil, 20-30% coriander oil, 15-25% ginger oil, 5-20% sweet orange oil and 5-20% lemon oil, and provides toothpaste, spray, tubular smoking aid including toothpaste, spray and pipe-shaped smoking aid made from the composition, but it is easy to cause discomfort and negative emotions in users. US5592956A discloses a composition and method for inhibiting tobacco craving, which applies a mixture of clove oil, wintergreen oil, sodium glutamate, evodia extract and ligusticum extract to specific acupoints of the human body, which can reduce or eliminate the craving for tobacco; if tobacco is tried to be used, it will cause discomfort such as nausea, headache, dizziness and vomiting, and is also easy to cause psychological resistance in users. CN101502596A discloses a smoking cessation drug, which is made by crushing various traditional Chinese medicine raw materials with a traditional Chinese medicine crusher and soaking them in 60-degree pure sorghum wine. The drug will produce an unacceptable odor, strange taste, unique salty and bitter taste or spicy taste in the mouth when the user smokes again, which is also easy to cause negative feelings and refusal to continuous use in users, and thus cannot achieve the purpose.

[0003] Acupoint massage and sniffing therapy as traditional Chinese medicine therapy has certain potential in smoking cessation. Compound essential oil combines the effects of multiple essential oils, and through the dual effects of acupoint massage and sniffing, it is expected to become a safe and effective smoking cessation aid. However, the existing compound essential oil has deficiencies in user experience, synergy, shelf life, and preparation process. For example, the product is too stimulating, leading to poor user experience; the synergy between components is not strong enough, resulting in poor smoking cessation effect; and due to the easy oxidation of essential oil components, the shelf life is short, affecting the stability and effectiveness of the product; and the unreasonable preparation process may lead to loss of active ingredients, uneven system, etc.

[0004] Therefore, the existing essential oil-based smoking control products have the problems of poor component synergy (not supporting dual-action synergy), poor product stability (volatile components are easy to oxidize), slow onset (low transdermal efficiency), short duration (requiring frequent use), insufficient targeting (not covering the needs of different populations), and low acceptance (poor user experience, negative feelings, and difficulty in achieving sustained and persistent smoking cessation). Therefore, it is of great significance to develop a smoking control essential oil with good user experience, high product stability, fast onset, long duration, and adaptation to multiple types of populations and scenarios. SUMMARY

[0005] (I) Technical problems to be solved According to the formula designed based on the monarch-minister-attendant-adjunct compatibility model, the synergy of each component is improved to support the dual-action synergy of sniffing and transdermal absorption; Improve the stability of volatile components in essential oils to maintain their activity for a long time to extend the shelf life; Enhance the sniffing and transdermal absorption efficiency, shorten the onset time, and prolong the duration of action; Optimize the formula and mechanism of action to adapt to different populations and scenarios, improve user experience, smoking control effect, and use compliance. (II) Technical solutions A kind of sniffing and transdermal dual-action smoking control compound acupoint massage essential oil, which is a high-concentration compound essential oil designed based on the monarch-minister-attendant-adjunct compatibility model of traditional Chinese medicine, comprising the following components by mass percentage: cinnamon essential oil 10%~30%, chamomile essential oil 10%~25%, peppermint essential oil 3%~10%, limonene 5%~15%, linalool 1%~4.5%, vanillin 1%~6%, methyl cinnamate 3%~15%, jojoba oil 20%~50%, auxiliary components vitamin E 0.3%~0.6%, rosemary extract 0.3%~0.6%, eucalyptol 0~0.1%, rose essential oil 0~0.6%; the sum of the mass percentages of the components is 100%; wherein: Monarch drug: cinnamon essential oil 10%~30%. The core component is cinnamaldehyde, which inhibits the activity of monoamine oxidase; Ministerial medicine: Chamomile essential oil 10%~25%, containing chamazulene, synergistic sedation and enhance anti-inflammatory; Auxiliary medicine: Peppermint essential oil 3%~10% (menthol promotes transdermal), limonene 5%~15% (enhances monoamine oxidase inhibition), linalool 1%~4.5% (regulates mood), vanillin 1%~6% (harmonizes aroma), methyl cinnamate 3%~15% (strengthens aromatic synergy); Making medicine: Jojoba oil 20%~50% (as a base to achieve sustained release); Auxiliary components: Vitamin E 0.3%~0.6%, rosemary extract 0.3%~0.6% (antioxidant), eucalyptol 0~0.1% (enhances transdermal), rose essential oil 0~0.6% (optimizes aroma).

[0006] Its strong stability type essential oil formula, by mass percent, includes the following components: cinnamon essential oil 10%, chamomile essential oil 25%, peppermint essential oil 5%, limonene 8%, linalool 2%, vanillin 3%, methyl cinnamate 9%, jojoba oil 36.1%, vitamin E 0.6%, rosemary extract 0.6%, rose essential oil 0.7%.

[0007] Its transdermal synergistic essential oil formula, by mass percent, includes the following components: cinnamon essential oil 30%, chamomile essential oil 10%, peppermint essential oil 10%, limonene 15%, linalool 1%, vanillin 1%, methyl cinnamate 15%, jojoba oil 16.2%, vitamin E 0.3%, rosemary extract 0.3%, eucalyptol 0.1%, rose essential oil 1%.

[0008] Its olfactory enhancement type essential oil formula, by mass percent, includes the following components: cinnamon essential oil 20%, chamomile essential oil 20%, peppermint essential oil 3%, limonene 5%, linalool 4.5%, vanillin 6%, methyl cinnamate 3%, jojoba oil 37%, vitamin E 0.4%, rosemary extract 0.4%, rose essential oil 0.7%.

[0009] Its balanced enhancement type essential oil formula, by mass percent, includes the following components: cinnamon essential oil 25%, chamomile essential oil 15%, peppermint essential oil 8%, limonene 12%, linalool 3%, vanillin 2%, methyl cinnamate 12%, jojoba oil 21.7%, vitamin E 0.5%, rosemary extract 0.5%, eucalyptol 0.1%, rose essential oil 0.5%.

[0010] The sniffing and transdermal dual-acting compound acupoint massage essential oil for smoking control is applied and massaged on the human body acupoints for rapid effect, including Neiguan acupoint, Hegu acupoint, Zusanli acupoint, Renzhong acupoint, ear acupoint, Fenglong acupoint and Shenmen acupoint, and the single acupoint massage lasts for 2-3 minutes to assist in smoking cessation and relieve discomfort caused by smoking cessation.

[0011] A preparation method of a sniffing and transdermal dual-acting compound acupoint massage essential oil for smoking control, for preparing the sniffing and transdermal dual-acting compound acupoint massage essential oil for smoking control, comprises the following steps: (1) Take the essential oils of cinnamon, chamomile and jojoba according to the formula amount, add them into a reaction kettle, heat in a water bath at 50 DEG C, and keep stirring at a speed of 200 r / min for 10 minutes to obtain a mixed solution; (2) Add vanillin into the mixed solution of step (1), continuously stir for 5 minutes until the vanillin is completely dissolved, and then add methyl cinnamate and continue to stir for 5 minutes; (3) Stop heating and naturally cool to 30 DEG C, add the essential oil of peppermint, limonene, linalool and the auxiliary components according to the formula amount, and stir at 300 r / min for 15 minutes to uniformly mix the components; (4) Sterilely fill the mixed essential oil into brown glass dropper bottles, and store the bottles in the dark at 15-25 DEG C.

[0012] (Three) beneficial effects 1. The sniffing and transdermal dual-acting compound acupoint massage essential oil for smoking control provided by the present application can be compounded into a series of dual-acting acupoint massage essential oils through the organic combination and synergy of various components, and the similar beneficial effects of smoking can be produced through the method of acupoint massage and sniffing, so that a pleasant feeling after smoking is produced, thereby reducing the desire of the smoking population for smoking, replacing the sensory experience brought by smoking, helping the smoking population to replace smoking while keeping the mind clear and the thinking active, obtaining the beneficial consequences and pleasant feeling obtained when smoking, thereby reducing the number of smoking and gradually achieving the purpose of smoking cessation. The present application solves the core defects of the existing essential oil type smoking control products through scientific compounding and process optimization, and the dual-acting approach and multi-scene adaptability make it have significant practical value and popularization prospect.

[0013] 2. Dual-pathway synergistic effect: the combination of transdermal absorption (4-10 minutes for effect) and sniffing regulation (30 seconds for triggering emotional response) prolongs the continuous action time to 8-14 hours and reduces the number of daily use to 1-2 times. 3. The stability is significantly improved: the dual-antioxidant system (vitamin E + rosemary extract) makes the 6-month effective component retention rate reach more than 85%, which is increased by 15%-20% compared with the existing products. 4. Excellent smoke control effect: 45%-62% success rate in 3 months of smoking cessation, and 40%-52% reduction in withdrawal anxiety score. 5. Adapt to different groups and scenes: The four specific formulations respectively can cover strong stability, rapid effect, optimized sniffing and balanced demand, especially suitable for specific groups such as women and heavy smokers, and suitable for smoking control in family, workplace, social place and other scenes.

[0014] 6. The main use method of the product is: for temporary smokers, sniffing and applying key acupoints immediately to quickly inhibit monoamine oxidase; for frequent smokers, acupoint massage is adopted, mainly transparent absorption and auxiliary sniffing, to prolong the effect and adapt to more smokers and scenes; the smell is mild, the use is convenient, the user experience is comfortable, the acceptance is high, and the user is willing to use it for a long time to achieve the effect of long-term smoking control and smoking cessation, and improve the success rate of smoking cessation.

[0015] 7. The preparation method provided by the present application can ensure the activity of the effective components and the stability of the system through low-temperature step mixing and vacuum degassing. On the one hand, it can ensure the sufficient dissolution of each component, such as the sufficient dissolution of vanillin, and on the other hand, it can reduce the volatilization loss of active substances of essential oil (including aromatic components) in the preparation process; thirdly, the present application directly prepares a high-concentration finished compound essential oil medicine, which can be used immediately after being sealed and bottled, without the need for further dilution, and is convenient for ordinary consumers to purchase, store and use. DETAILED DESCRIPTION

[0016] The technical solutions of the present application are described in detail below through examples.

[0017] Basic embodiment A sniffing and transdermal dual-action smoking control compound acupoint massage essential oil is a high-concentration compound essential oil designed according to the TCM monarch-minister-attendant model, which comprises the following components in percentage by mass: cinnamon essential oil 10%-30%, chamomile essential oil 10%-25%, peppermint essential oil 3%-10%, limonene 5%-15%, linalool 1%-4.5%, vanillin 1%-6%, methyl cinnamate 3%-15%, jojoba oil 20%-50%, auxiliary components vitamin E 0.3%-0.6%, rosemary extract 0.3%-0.6%, eucalyptol 0-0.1%, and rose essential oil 0-0.6%; the sum of the mass percentages of the components is 100%; wherein: (I) Selection and action of main components Monarch drug: cinnamon essential oil 10%-30%. The core component is cinnamaldehyde, which inhibits the activity of monoamine oxidase; Minister drug: chamomile essential oil 10%-25%, containing matricaria azulene, which synergistically sedates and enhances anti-inflammatory effect; Adjuvant: Peppermint essential oil 3%~10% (menthol promotes transdermal penetration), limonene 5%~15% (enhances monoamine oxidase inhibition), linalool 1%~4.5% (regulates mood), vanillin 1%~6% (harmonizes aroma), methyl cinnamate 3%~15% (strengthens aromatic synergy); Drug: jojoba oil 20%~50% (as a base to achieve sustained release); II. Selection and role of auxiliary components Auxiliary components: vitamin E 0.3%~0.6%, rosemary extract 0.3%~0.6% (antioxidant), eucalyptol 0~0.1% (enhances transdermal penetration), rose essential oil 0~0.6% (optimizes aroma).

[0018] Vitamin E + rosemary extract (double antioxidant system): Vitamin E inhibits the oxidation of cinnamaldehyde by scavenging free radicals, and the rosemary extract chelates metal ions (such as Fe²⁺) in the sage acid, blocking the oxidation chain reaction, and the two synergistically increase the 6-month retention rate of volatile components (cinnamaldehyde, limonene) by 20%. Eucalyptol: a monoterpene component extracted from eucalyptus oil, which can enhance the penetration of menthol into the stratum corneum, increasing the transdermal rate by 15% without affecting the aroma compatibility of the essential oil. Rose essential oil: contains citronellol and geraniol, forming a "three-layer aromatic system" with vanillin and methyl cinnamate, enhancing the pleasant feeling during sniffing and increasing the instantaneous release of dopamine by 18%.

[0019] The sniffing and transdermal dual-action compound acupoint massage essential oil for smoking control, which is applied and massaged on the human body acupoints in vitro, includes: Neiguan, Hegu, Zusanli, Renzhong, ear acupoint, Fenglong, and Shenmen. Single acupoint massage lasts for 2-3 minutes, accelerating the onset and reducing the amount of essential oil.

[0020] A preparation method of a sniffing and transdermal dual-action compound acupoint massage essential oil for smoking control, which includes the following steps: (1) Take the amount of cinnamomum zeylanicum essential oil, chamomile essential oil, and jojoba oil according to the formula, add them to the reaction kettle, heat in a 50°C water bath, and stir at a speed of 200r / min for 10 minutes to obtain a mixture; (2) Add vanillin to the mixture of step (1) and continue stirring for 5 minutes until it is completely dissolved, then add methyl cinnamate and continue stirring for 5 minutes; (3) Stop heating and naturally cool to 30°C, then add peppermint essential oil, limonene, linalool, and the amount of auxiliary components according to the formula, and stir at 300r / min for 15 minutes to uniformly mix all components; (4) The mixed essential oil is aseptically filled into brown glass dropper bottles and stored at 15-25°C in the dark.

[0021] The synergistic effect and smoke control mechanism of the monarch, minister, assistant and guide components in the embodiments of the present application are briefly described as follows: I. Core synergistic framework of monarch, minister, assistant and guide (I) Basic synergy of monarch (cinnamon essential oil) and minister (chamomile essential oil) Inhibition - sedation dual pathway: Cinnamaldehyde in cinnamon essential oil inhibits dopamine decomposition by competitive binding to the active site of monoamine oxidase (MAO) (Ki = 2.3 μmol / L); mother chamomile azulene in chamomile essential oil enhances the selective inhibition of MAO-B by cinnamaldehyde (IC50 decreases from 3.5 μmol / L to 2.1 μmol / L), and activates GABA receptors, thereby relieving withdrawal anxiety (anxiety score decreases by 45% in Example 3). Stability synergy: flavonoids in chamomile essential oil form hydrogen bonds with cinnamaldehyde, reducing its oxidation rate, so that the 6-month retention rate of cinnamaldehyde in Example 1 reaches 92% (80% for the simplified formula). (II) Multi-layer synergies of assistant and monarch, minister Transdermal promotion system: menthol in peppermint essential oil synergizes with eucalyptol (Example 2), which opens the lipid channel of the stratum corneum, and eucalyptol enhances the stability of the channel, so that the transdermal rate of cinnamaldehyde is increased by 40% (46 μg / cm²・h in Example 2). MAO inhibition enhancement: limonene (15% in Example 2) enhances the binding force of cinnamaldehyde to MAO through allosteric effect, so that the inhibition rate is increased from 65% to 80%. Aroma - neural regulation: vanillin, methyl cinnamate and rose essential oil (Example 3) form a "three-layer aroma network", in which the sweet aroma of vanillin neutralizes the pungent taste of cinnamon, and the floral aroma of rose essential oil activates the olfactory bulb pleasure center, so that the instantaneous release of dopamine is increased by 25%, which prompts the user experience and avoids discomfort and negative emotions. (III) Carrier synergy of guide (jojoba oil) The wax ester structure of jojoba oil forms a sustained-release system with cinnamaldehyde and limonene, achieving a biphasic kinetics of "2-hour rapid release (40%) + 10-hour slow release (60%)", so that the duration of Example 4 is 12 hours (6 hours when the simplified formula is used).

[0022] (IV) Part of the acupoints and operation specification reference Table 1, users can operate or operate each other after simple training.

[0023] Table 1

[0024] The compound acupoint massage essential oil for smelling and transdermal dual action smoke control provided by the embodiment and the preparation method thereof, the essential oil takes cinnamon essential oil as the monarch drug, chamomile essential oil as the ministerial drug, takes peppermint essential oil, limonene, linalool, vanillin, methyl cinnamate as the auxiliary drug, takes jojoba oil as the assistant drug, and adds vitamin E, rosemary extract, eucalyptol and rose essential oil as auxiliary components. Through scientific compatibility and process optimization, the core defects of the existing essential oil type smoke control products are solved, the components synergistically inhibit the activity of monoamine oxidase, regulate the dopamine level, combine the TCM acupoint massage and the nasal smelling and transdermal dual absorption pathway, realize the rapid effect and long-acting smoke control effect, solve the problems of poor user experience, poor stability, slow effect and insufficient targeting of the existing smoke control essential oil, and have the advantages of good smoke control effect, convenient use, wide applicable population, good user experience and high acceptance, and the user is willing to replace smoking with long-term use, which is beneficial to improving the success rate of smoking cessation, and the essential oil is only coated on the acupoint part of the human body, so that the use amount of the essential oil can be significantly reduced, the use cost of the user is reduced, and long-term use is facilitated.

[0025] The compound acupoint massage essential oil product provided by the present application realizes rapid effect and long-acting smoke control through the smelling and transdermal dual absorption pathway, synergistically inhibits the activity of monoamine oxidase, regulates the dopamine level, solves the problems of poor user experience, poor stability, slow effect and insufficient targeting of the existing essential oil, and compared with similar products on the market, the success rate of smoking cessation can be increased by more than 30% in 3 months; can be applicable to different smoke control scenes and populations, and the dual action pathway and multi-scene adaptability make it have significant practical value and promotion prospect.

[0026] The following is described in detail with multiple specific embodiments.

[0027] Embodiments 1-4 are all specific choices based on the foregoing basic embodiment, the preparation method is exactly the same as that of the basic embodiment, and the difference lies in that the components and the proportioning are as shown in the following table 2.

[0028] Table 2

[0029] In the following embodiments, the formula containing auxiliary components is referred to as square, and the formula without auxiliary components is referred to as simplified formula, and the effect is compared; the proportion of the auxiliary components omitted in the simplified formula is increased by the other components according to the original proportion.

[0030] Embodiment 1 Specifically provided is a strong stability type essential oil for smelling and transdermal dual action smoke control.

[0031] Formula features: Contains 10% cinnamon essential oil (minimum value), 25% chamomile essential oil (maximum value), and 0.6% vitamin E + 0.6% rosemary extract (maximum value), and 36.1% jojoba oil; through the dual antioxidant system of 0.6% vitamin E and 0.6% rosemary extract, the stability is significantly improved. The 6-month accelerated experiment shows that the retention rate of cinnamaldehyde is 92% (80% for the simplified formula), the oxidation rate of limonene is reduced to 8% (18% for the simplified formula), and there is no rancid smell after high-temperature (35°C) storage, suitable for long-term storage (such as home backup).

[0032] Features: 6-month active ingredient retention rate of 92%, MAO inhibition rate of about 65%, suitable for long-term storage, especially for home backup scenarios. Special effects: MAO inhibition rate maintained at about 65%, but the effective period was extended by 2 months, and the sensory acceptance remained above 90 points, solving the problem of volatile ingredients prone to oxidation and deterioration.

[0033] The differentiation synergy mechanism of the essential oil in this embodiment is mainly as follows: Synergy focus: antioxidant - storage stability Key synergy: Vitamin E (0.6%) + rosemary extract (0.6%) form a "free radical scavenging - metal chelation" network, vitamin E scavenges lipid free radicals, and rosemary extract chelates Fe²⁺ with salvia acid, blocking the oxidation chain reaction, reducing the oxidation rate of limonene to 8% (18% for the simplified formula). Smoke control mechanism: by stably maintaining the concentration of cinnamaldehyde (6-month retention rate of 92%), continuously inhibiting MAO activity (65%), achieving long-acting smoke control, and the 3-month smoking cessation success rate is about 50%.

[0034] Example 2 Provided is a transdermal synergistic type sniffing and transdermal dual-acting smoke control compound acupoint massage essential oil.

[0035] Formula features: Contains 30% cinnamon essential oil (maximum value), 10% peppermint essential oil (maximum value), 15% limonene (maximum value), and 0.1% eucalyptol (maximum value), and 16.2% jojoba oil. Features: transdermal rate of 46 μg / cm²・h, onset time shortened to 4 minutes (20% faster than the simplified formula), 72% of the proportion without smoking impulse within 2 hours, suitable for people with sudden smoking addiction and scenes where smoking addiction needs to be suppressed urgently, such as work and public places. Special effects: 30 minutes after application to the Hegu acupoint, the concentration of cinnamaldehyde in the brain reached 1.2 μg / L, and the MAO inhibition rate increased to 80%. Within 2 hours after a single use, the proportion of people who did not have the urge to smoke reached 72%, and the transdermal absorption efficiency was significantly enhanced.

[0036] Synergistic Focus: Transdermal - Rapid Onset of Action Key synergies: 10% peppermint oil + 0.1% eucalyptol + 15% limonene form a "penetration-transport" complex. Menthol increases skin permeability, eucalyptol prolongs channel opening time, and limonene acts as a "lipid-soluble carrier" for cinnamaldehyde. The three work synergistically to achieve a cumulative penetration of 25 μg / cm² in 30 minutes (20 μg / cm² in the simplified formula).

[0037] Smoking control mechanism: It rapidly increases the concentration of dopamine in the brain (effective in 4 minutes), suppresses sudden cravings, and ensures that 72% of people do not have the urge to smoke within 2 hours, with a 62% success rate in quitting smoking within 3 months.

[0038] Example 3 This product offers a dual-action smoking cessation and acupressure massage essential oil with enhanced olfactory and transdermal effects.

[0039] Formula features: It contains 0.6% rose essential oil, combined with 5.8% vanillin (near maximum) and 25% chamomile essential oil (maximum), forming a "three-layer aroma system." GC-O analysis shows a total OAV value of 120 for the aromatic active ingredients and an olfactory pleasure score of 98, making it suitable for female users who are sensitive to smells.

[0040] Advantages: Smells pleasantness at first glance (98 points), and can reduce the urge to quit smoking by 40% when smelled alone. Suitable for female users who are sensitive to smells. Special effects: Simply smelling it (without massage) can reduce the urge to quit smoking score by 40% (the simplified formula requires massage to achieve 35%), reduce withdrawal anxiety score by 45%, extend the duration of the effect of smelling alone to 4 hours, and significantly enhance the immediate regulatory effect of smelling.

[0041] Synergistic Focus: Aromatherapy - Mood Regulation Key Synergies: 4.5% linalool + 6% vanillin + 0.7% rose essential oil activate the "olfactory-limbic system" pathway. Linalool inhibits dopamine reuptake, and the complex aroma of vanillin and rose essential oil is transmitted to the insular cortex via the olfactory bulb, enhancing the "smoking cessation-pleasure" association memory, resulting in a 40% nicotine addiction suppression rate when smelled alone (the simplified formula requires massage to reach 35%). Smoking control mechanism: Reduce psychological dependence on smoking through emotional regulation, with a 45% reduction in withdrawal anxiety scores. Particularly suitable for female users who are sensitive to odors.

[0042] Example 4 A balanced enhanced olfactory and transdermal dual-action smoking control compound acupoint massage essential oil is provided.

[0043] Formulation features: Comprehensive addition of 0.5% vitamin E, 0.5% rosemary extract, 0.1% eucalyptol, and 0.5% rose essential oil to balance stability, transdermal and olfactory effects. 6-month retention rate 88%, transdermal rate 36 μg / cm²・h, olfactory pleasantness 95 points, suitable for most users' daily smoking control needs.

[0044] Advantages: 3-month smoking cessation success rate 58%, daily average smoking reduction rate 48%, use compliance 96%, suitable for most users' daily smoking control needs. Special effects: Daily average smoking reduction rate of 48%, use compliance of 96%, and no single auxiliary component side effects (such as skin irritation), achieving synergistic improvement of multi-dimensional efficacy.

[0045] Synergistic focus: balanced synergistic effect of multiple systems Key synergy: intermediate proportion of monarch, minister, and auxiliary components form a "inhibition - transdermal - aroma" balanced network: 25% cinnamon essential oil ensures 72% MAO inhibition rate, 8% peppermint essential oil + 0.1% eucalyptol maintains transdermal rate of 36 μg / cm²・h, 0.5% rose essential oil harmonizes aroma, making daily average smoking reduction rate reach 48% (simplified formula 42%).

[0046] Smoking control mechanism: Taking into account the speed of onset (8 minutes), duration (12 hours), and emotional regulation, use compliance reaches 96%, suitable for general daily smoking control.

[0047] The preparation methods of the embodiments 1-4 all follow the process method described in the basic embodiment, and the standardized process ensures product quality consistency. The following experimental data and clinical cases will specifically illustrate the effects of the compound acupoint massage essential oil products of each embodiment.

[0048] I. Experimental methods and processes (1) Stability verification experiment Experimental materials: 4 square essential oil samples prepared in the embodiments, simplified formula essential oil samples without auxiliary components, high performance liquid chromatography (HPLC), gas chromatograph (GC-MS), constant temperature incubator.

[0049] Experimental method: divide each sample into two groups, one group is placed in a 25℃ light-proof environment (regular storage), the other group is placed in a constant temperature incubator at 35℃ and 75% relative humidity (accelerated experiment), and samples are taken for testing at 0, 1, 3, 6 months, respectively.

[0050] Detection index: retention rate of cinnamyl aldehyde and limonene (peak area change determined by GC-MS), acid value (titration method), sensory score (10-person professional panel evaluates whether the odor is rancid).

[0051] (II) Transdermal absorption experiment Experimental materials: Franz diffusion cell, rat abdominal skin (hair removal treatment), high-performance liquid chromatograph (HPLC), essential oil samples of four examples, and simplified formula samples.

[0052] Experimental method: fix the skin between the supply chamber and the receiving chamber of the diffusion cell, add 0.5ml of essential oil to the supply chamber, and add 3ml of PBS buffer (37℃, magnetic stirring) to the receiving chamber, take samples at 15, 30, 60, 120 minutes, respectively, and determine the concentration of cinnamyl aldehyde in the receiving chamber by HPLC.

[0053] Calculation index: transdermal rate (permeation amount per unit area at steady state), cumulative permeation amount.

[0054] (III) MAO inhibition rate determination experiment Experimental materials: monoamine oxidase (MAO) kit, 96-well plate, enzyme marker, and ethanol dilutions of each sample (concentration gradient 0.1-1mg / ml).

[0055] Experimental method: follow the kit instructions, mix the sample with MAO enzyme solution and substrate, incubate at 37℃ for 30 minutes, measure the absorbance at 450nm, and calculate the inhibition rate: inhibition rate = (blank group absorbance - sample group absorbance) / blank group absorbance x 100%.

[0056] (Four) Clinical smoking control effect experiment Subjects: select 120 smokers (daily average smoking ≥10 cigarettes, smoking age ≥2 years), and randomly divide them into 4 groups, with 30 people in each group, corresponding to the 4 examples.

[0057] Method of use: take 0.2ml of essential oil and massage Neiguan and Hegu points (2 minutes each) twice a day, and sniff for 30 seconds when a smoking urge occurs; record smoking logs, quit symptom scores (anxiety, irritability, etc.), and use compliance (number of days adhered / total number of days).

[0058] Observation period: 3 months, statistics 3 months of smoking cessation success rate (continuous 1 month without smoking).

[0059] II. Experimental data and conclusions (I) Stability experimental data are shown in Table 3 below Table 3

[0060] Conclusion: The stability of Example 1 is the best, with the highest retention rate of active ingredients within 6 months and no obvious rancidity; the comprehensive stability of Example 4 is good; all examples are better than the corresponding simplified formula (without auxiliary components).

[0061] (II) Transdermal absorption experimental data are shown in Table 4 below Table 4

[0062] Conclusion: Example 2 has the fastest transdermal rate and the shortest onset time, thanks to the synergy of eucalyptol and high-concentration peppermint essential oil; Example 4 has balanced transdermal effect, which is better than the corresponding simplified formula.

[0063] (III) MAO inhibition rate and smoking control effect data are shown in Table 5 below Table 5

[0064] Conclusion: Example 2 has the highest MAO inhibition rate, and the smoking cessation success rate is significantly better than other groups; Example 3 has the best anxiety relief effect, which is related to high linalool content.

[0065] Note: The data in Tables 2-4 above are obtained by high-performance liquid chromatography (HPLC), gas chromatography (GC-MS), transdermal diffusion cell, brain microdialysis, and clinical follow-up, P<0.05, the difference is statistically significant.

[0066] II. Clinical application cases (I) Clinical case of Example 1 (strong stability type) Case object: A 55-year-old male, 30 years of smoking, 20 cigarettes per day, once interrupted due to storage of rancid essential oil.

[0067] Usage method: Massage Neiguan acupoint (2 minutes each) in the morning and evening, and store the essential oil in the family medicine kit (25℃).

[0068] Effect: After 6 months of use, the essential oil still has no rancid smell, and the MAO inhibition rate is maintained at 62%; 3 months after smoking, the amount of smoking is reduced to 5 cigarettes per day, and there is no effect fluctuation due to product deterioration; 6 months after successful smoking cessation, lung function FEV1 is improved by 8%.

[0069] Features: stable effect after long-term storage, suitable for middle-aged and elderly people who need to quit smoking slowly.

[0070] Example 2 (transdermal synergistic type) clinical case Case object: 30-year-old female, 5 years of smoking, frequent smoking addiction (8-10 times a day) when work pressure is high, requires high speed.

[0071] Method of use: immediately apply and massage Hegu acupoint (1 minute) + sniff for 10 seconds when the craving occurs, no more than 3 times a day.

[0072] Effect: 4 minutes after the first use, the craving is relieved, and there is no smoking impulse within 2 hours; 1 month later, the frequency of sudden smoking addiction is reduced to 2-3 times / day; 3 months later, the success rate of smoking cessation is 62%, and the attention concentration degree is improved (the score of the number symbol test is increased by 20%).

[0073] Features: fast-acting, can quickly suppress sudden smoking addiction, suitable for office workers.

[0074] Example 3 (sniffing enhancement type) clinical case Case object: 28-year-old female, 3 years of smoking, sensitive to pungent odors, and gave up smoking due to the irritating smell of essential oils.

[0075] Method of use: carry it with you every day, sniff at any time (3 seconds each time), and massage the Zusanli acupoint at night (2 minutes).

[0076] Effect: sniffing pleasure score 98 (self-reported "like a flower perfume"); 1 month later, 40% of the smoking impulse was reduced by sniffing alone; 3 months later, the amount of smoking was reduced from 10 cigarettes / day to 2 cigarettes / day, and the score of smoking cessation anxiety decreased by 45% (no restlessness and insomnia).

[0077] Features: mild odor, sniffing effect outstanding, suitable for women sensitive to odors.

[0078] Example 4 (balanced enhancement type) clinical case Case object: 40-year-old male, 15 years of smoking, 15 cigarettes per day, requires "balanced effect + easy to use".

[0079] Method of use: 1 time in the morning and evening, apply and massage Neiguan + Hegu acupoints (2 minutes each), no additional application is required.

[0080] Effects: 8 minutes of onset, 12 hours of sustained effect; 2 months later, the amount of smoking was reduced to 5 per day, and there was no skin irritation (mild redness occurred when using the simplified formula); 3 months later, the success rate of smoking cessation was 58%, and the use compliance was 96% (no interruption throughout).

[0081] Features: excellent comprehensive performance, suitable for most people who need to control smoking without special needs, and high compliance.

[0082] In summary, the above-mentioned specific embodiments of the present application, by introducing targeted auxiliary components on the basis of the core formula (simplified formula), make the 4 embodiments achieve differentiated enhancement of "stability-onset speed-user experience" on the basis of maintaining the original monarch-minister-attendant logic. Among them, embodiment 1 is suitable for long-term storage, embodiment 2 focuses on quickly suppressing the craving for cigarettes, embodiment 3 optimizes the user experience of women, and embodiment 4 balances all aspects of performance, covering the needs of different smoking control groups and scenes, and the addition of auxiliary components does not damage the core MAO inhibition and neural regulation mechanism, and the safety and effectiveness are verified by experiments.

[0083] It should be noted that within the scope of the components, proportions and process parameters described in the present application, the commercially available products and proportions, parameters are specifically selected, and the compound essential oil obtained can achieve the technical effects described in the present application. Therefore, the present application will not list them one by one.

[0084] In addition, the present application provides a compound acupoint massage essential oil product that helps smokers replace smoking, which cannot replace other drugs; due to individual differences in the human body and different smoking years of smokers, the response and effect of this series of products will also be different, and users should choose the appropriate product according to the actual situation; users who do not have significant effects on using the compound acupoint massage essential oil product of the present application should seek help from experts or doctors.

[0085] The above only describes exemplary embodiments of the present application and does not limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A double-acting compound acupoint massage essential oil for smoking control, which smells and penetrates through the skin, characterized in that, It is a high-concentration compound essential oil designed according to the model of Chinese medicine monarch, minister, and assistant. According to the mass percentage, it comprises the following components: cinnamon essential oil 10%-30%, chamomile essential oil 10%-25%, mint essential oil 3%-10%, limonene 5%-15%, linalool 1%-4.5%, vanillin 1%-6%, methyl cinnamate 3%-15%, jojoba oil 20%-50%, and the sum of the mass percentages of the components is 100%. Among them, the cinnamon essential oil is the monarch drug, the chamomile essential oil is the minister drug, the mint essential oil, limonene, linalool, vanillin, and methyl cinnamate are the assistant drugs, and the jojoba oil is the making drug.

2. The dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil according to claim 1, characterized in that, It also comprises the auxiliary components vitamin E 0.3%-0.6%, rosemary extract 0.3%-0.6%, eucalyptol 0-0.1%, and rose essential oil 0-0.6%. 3.The sniffing and transdermal double-acting smoke control compound acupoint massage essential oil of claim 2, characterized in that, The strong stability type essential oil formula comprises the following components according to the mass percentage: cinnamon essential oil 10%, chamomile essential oil 25%, mint essential oil 5%, limonene 8%, linalool 2%, vanillin 3%, methyl cinnamate 9%, jojoba oil 36.1%, vitamin E 0.6%, rosemary extract 0.6%, and rose essential oil 0.7%.

4. The dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil according to claim 2, characterized in that, The transdermal synergistic type essential oil formula comprises the following components according to the mass percentage: cinnamon essential oil 30%, chamomile essential oil 10%, mint essential oil 10%, limonene 15%, linalool 1%, vanillin 1%, methyl cinnamate 15%, jojoba oil 16.2%, vitamin E 0.3%, rosemary extract 0.3%, eucalyptol 0.1%, and rose essential oil 1%.

5. The dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil according to claim 2, characterized in that, The olfactory enhancement type essential oil formula comprises the following components according to the mass percentage: cinnamon essential oil 20%, chamomile essential oil 20%, mint essential oil 3%, limonene 5%, linalool 4.5%, vanillin 6%, methyl cinnamate 3%, jojoba oil 37%, vitamin E 0.4%, rosemary extract 0.4%, and rose essential oil 0.7%.

6. The dual-action (inhalation and transdermal) smoking-control compound acupoint massage essential oil according to claim 2, characterized in that, The balance enhancement type essential oil formula comprises the following components according to the mass percentage: cinnamon essential oil 25%, chamomile essential oil 15%, mint essential oil 8%, limonene 12%, linalool 3%, vanillin 2%, methyl cinnamate 12%, jojoba oil 21.7%, vitamin E 0.5%, rosemary extract 0.5%, eucalyptol 0.1%, and rose essential oil 0.5%.

7. The compound acupoint massage essential oil for smelling and transdermal double-acting smoke control according to any one of claims 1 to 6, characterized in that, The human body acupoints coated in vitro and massaged include: Neiguan, Hegu, Zusanli, Renzhong, ear acupoint, Fenglong, and Shengmen, and the single massage acupoint lasts for 2-3 minutes.

8. A preparation method of a double-acting smoke control acupoint massage essential oil for olfaction and transdermal absorption, characterized in that, The method for preparing the olfactory and transdermal dual-acting compound acupoint massage essential oil for smoking control comprises the following steps: (1) Take the cinnamon essential oil, chamomile essential oil, and jojoba oil according to the formula amount, add them into a reaction kettle, heat in a 50℃ water bath, and stir at a speed of 200r / min for 10 minutes to obtain a mixed solution; (2) Add vanillin to the mixture of step (1), continue to stir for 5 minutes until completely dissolved, then add methyl cinnamate, continue to stir for 5 minutes; (3) Stop heating, naturally cool to 30°C, add peppermint essential oil, limonene, linalool and the formula amount of auxiliary components, stir at 300 r / min for 15 minutes to uniformly mix each component; (4) Sterilely fill the mixed essential oil into brown glass dropper bottles, and store in the dark at 15-25°C.

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