Bone-setting, collateral-activating and pain-relieving liquid as well as preparation method and application thereof

Abstract

According to the bone-setting, collateral-activating and pain-relieving liquid, frankincense semen, myrrh semen, ligusticum wallichii, safflower and pseudo-ginseng are used as core components for promoting blood circulation to remove blood stasis, and lycopodium clavatum and caulis spatholobi are used as auxiliary components for relaxing tendons and activating collaterals, astragalus membranaceus, polygonum multiflorum and angelica sinensis are used for invigorating qi and blood, moutan bark is used for balancing warm properties, pericarpium citri reticulatae is used for regulating qi activity, and the bone-setting, collateral-activating and pain-relieving liquid is prepared. Effective components are extracted through a low-temperature ethanol extraction and water decoction concentration process, and the transdermal absorption preparation is prepared through mixing, blending, filtering and sterilizing. In clinical application, aiming at fascia ligament vitreous lesions and osteoarticular diseases, local administration is performed after continuous pressing and palm massage pretreatment, so that pain can be quickly relieved, swelling can be eliminated, and the degree of motion of joints can be improved. Experiments show that the total effective rate of the preparation within 7-day treatment course reaches 92%, and the preparation is free of irritation and anaphylaxis, has multiple effects of promoting blood circulation to arrest pain, clearing and activating the channels and collaterals and tonifying and repairing, is suitable for adjuvant therapy of cervical spondylosis, lumbar disc herniation, soft tissue injury and other diseases, and provides an innovative scheme for modernization of traditional Chinese medicines.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a bone-setting collateral vessel pain-relieving liquid with the functions of activating blood and resolving stasis, dredging channels and collaterals, reducing swelling and relieving pain, and improving local blood circulation, which is suitable for the auxiliary treatment of fascia and ligament injury, joint pain and other diseases. BACKGROUND

[0002] In the prior art, the treatment methods for fascia and ligament injury and joint pain mainly include oral non-steroidal anti-inflammatory drugs (such as ibuprofen and diclofenac sodium), external ointments (such as flurbiprofen gel patch and shangshizhitong ointment), and physical therapy (such as acupuncture, massage, and hot compress). However, these methods have significant limitations: oral drugs need to be absorbed by the gastrointestinal tract and have a first-pass effect in the liver, and the onset time is usually more than 30 minutes, and long-term use can easily cause adverse reactions such as gastrointestinal ulcers and liver and kidney function damage; traditional ointments can be administered locally, but the matrix components (such as rubber and resin) may block the pores, resulting in a drug penetration efficiency of less than 20%, and the irritating components such as capsaicin and methyl salicylate contained therein can easily cause contact dermatitis, and the patient compliance is poor. In addition, physical therapy can relieve symptoms, but it cannot directly repair damaged fascia and ligament tissue, and the effect is limited for chronic injury or recurrent cases.

[0003] In recent years, although transdermal drug delivery technology has made progress, existing traditional Chinese medicine patches still face problems such as complex formula, low extraction rate of active ingredients (usually less than 50%), and unstable drug efficacy. For example, some products use ethanol extraction process, which can dissolve some fat-soluble components, but it can destroy the volatile oil active substances in frankincense and myrrh, reducing the analgesic effect; another study attempts to enhance permeability through nano-carriers or microneedle arrays, but the process cost is high, which is difficult to popularize and apply. At the same time, local injection therapy (such as glucocorticoid block needle) of Western medicine can quickly relieve pain, but it can cause complications such as tendon atrophy and osteoporosis, and does not solve the root cause of blood stasis and blocked meridians. SUMMARY

[0004] The present application aims to provide an external traditional Chinese medicine preparation with strong permeability, rapid action, and high safety, which is made of natural traditional Chinese medicine as raw material through scientific proportioning, and realizes the effects of rapid pain relief and promotion of tissue repair through transdermal absorption.

[0005] To achieve the above-mentioned purpose, the present application realizes the following technical scheme:

[0006] A bone-setting collateral vessel pain-relieving liquid is prepared from the following raw materials in the following weight percentages:

[0007] Frankincense extract 5%-10%;

[0008] Myrrh extract 5%-10%;

[0009] Ligusticum striatum 8%-12%;

[0010] Safflower 6%-10%;

[0011] Panax notoginseng 5%-8%;

[0012] Dried tangerine peel 4%-7%;

[0013] Lycopodium clavatum 6%-9%;

[0014] Psoralea corylifolia 5%-8%;

[0015] Polygonum multiflorum 4%-6%;

[0016] Astragalus 8%-12%;

[0017] Angelica sinensis 6%-10%;

[0018] Moutan bark 5%-8%;

[0019] Chicken blood vine 8%-12%;

[0020] Potassium sorbate 0.1%-0.3%;

[0021] Add purified water to bring the level to 100%.

[0022] Furthermore, the weight percentages of the raw materials are as follows: frankincense extract 8%, myrrh extract 8%, chuanxiong rhizome 10%, safflower 8%, notoginseng 6%, tangerine peel 5%, lycopodium clavatum 7%, psoralea corylifolia 6%, he shou wu 5%, astragalus membranaceus 10%, angelica sinensis 8%, peony bark 6%, chicken blood vine 10%, potassium sorbate 0.2%, and purified water to make up to 100%.

[0023] A method for preparing the bone-setting and pain-relieving liquid as described in any one of claims 1-2, comprising the following steps:

[0024] (1) Semen extraction: Semen was obtained by low-temperature extraction of frankincense and myrrh;

[0025] (2) Water decoction concentration: Add water to the remaining Chinese medicinal materials and decoct twice, combine the filtrates and concentrate to a relative density of 1.10-1.15;

[0026] (3) Mixing and blending: Mix frankincense essence, myrrh essence and concentrate, add potassium sorbate and purified water, and stir until uniform;

[0027] (4) Sterilization and dispensing: The product is sterilized by filtration and dispensed into light-proof containers.

[0028] Furthermore, the temperature of the low-temperature extraction technology is 40-60℃, and the extraction time is 2-4 hours.

[0029] Further, in the water decocting and concentrating step, the first water quantity is 8-10 times of the total weight of the medicinal materials, and the decocting time is 1.5-2 hours; the second water quantity is 6-8 times of the total weight of the medicinal materials, and the decocting time is 1-1.5 hours.

[0030] The application of the bone-setting and collaterals-activating analgesic liquid according to any one of claims 1-2 to the preparation of an external medicine for treating fascia ligament injury, joint pain or soft tissue inflammation.

[0031] Further, the use method of the bone-setting and collaterals-activating analgesic liquid comprises the following steps:

[0032] (1) Inquiring and positioning: confirming the pain site and cause of the patient;

[0033] (2) Palpating by hand: pressing the pain point with the thumb or middle finger of the index finger to perceive the characteristics of fascia ligament glassy lesions;

[0034] (3) Pretreatment:

[0035] continuously pressing the pain point for 5 minutes;

[0036] massaging the pain point with the palm for 5 minutes until the skin is slightly hot;

[0037] (4) Drug administration: spraying the analgesic liquid on the affected area and gently rubbing until completely absorbed;

[0038] (5) Frequency: twice a day, and one treatment course is 7 days.

[0039] Further, the bone-setting and collaterals-activating analgesic liquid is suitable for the auxiliary treatment of cervical spondylosis, lumbar disc herniation, scapulohumeral periarthritis or sports injury.

[0040] The beneficial effects of the present application are:

[0041] Promoting blood circulation to remove blood stasis: frankincense, myrrh and sanchi promote blood stasis to disperse;

[0042] Dredging meridians and activating collaterals: chuanxiong, safflower and jixueteng dredge meridians and activate collaterals;

[0043] Resolving swelling and relieving pain: xijincuo and buguzhi relieve inflammatory reactions;

[0044] Repairing tissues: huangqi, danggui and heshouwu enhance local immunity and accelerate injury repair;

[0045] Strong targeting: positioning lesions by hand diagnosis and directly reaching the lesions by transdermal absorption technology;

[0046] Rapid effect: the pretreatment step improves skin permeability, and the pain is relieved within 10 minutes;

[0047] High safety: natural ingredients reduce the risk of allergy, and potassium sorbate meets the FDA preservation standard. DETAILED DESCRIPTION

[0048] The following is a more detailed, complete description of the solutions of the present application. Specific embodiments:

[0050] I. Raw material composition (wt%)

[0051] Olibanum extract 8g, Myrrh extract 8g, Chuanxiong 10g, Safflower 8g, Sanqi 6g, Tangerine peel 5g, Xijinci 7g, Buguzhi 6g, Heshouwu 5g, Huangqi 10g, Danggui 8g, Mudanpi 6g, Jixueteng 10g, Potassium sorbate 0.2g, purified water to 100ml.

[0052] Among them, the raw material drug property analysis of orthopedic pain-relieving liquid is as follows:

[0053] Olibanum extract

[0054] Drug property: bitter and pungent in taste, warm in nature, and belongs to heart, liver and spleen meridians;

[0055] Effect: Promoting blood circulation to stop pain, reducing swelling and promoting tissue regeneration, it is a key medicine for promoting blood circulation and unblocking meridians, and is used for treating pain in heart, stomach, hypochondrium, limbs and joints, and postpartum blood stasis.

[0056] Myrrh extract

[0057] Drug property: bitter and pungent in taste, warm in nature, and belongs to liver and spleen meridians;

[0058] Effect: Dispersing blood to stop pain and reducing swelling and promoting tissue regeneration, it can enhance the effect of promoting blood circulation and removing blood stasis when combined with olibanum, and is used for treating contusion and swelling pain and sore and swollen pain.

[0059] Chuanxiong

[0060] Drug property: bitter and pungent in taste, warm in nature, and belongs to liver and spleen meridians;

[0061] Effect: Promoting blood circulation and removing blood stasis, it is used for treating chest and hypochondrium pain, contusion and swelling pain, rheumatic arthralgia and headache and dysmenorrhea.

[0062] Safflower

[0063] Drug property: bitter and pungent in taste, warm in nature, and belongs to liver and spleen meridians;

[0064] Effect: Promoting blood circulation and removing blood stasis, it is used for treating blood stasis, dysmenorrhea, contusion and swelling pain and blood stasis. Sanqi

[0066] Drug property: bitter and pungent in taste, warm in nature, and belongs to liver and spleen meridians;

[0067] Effect: Promoting blood circulation and removing blood stasis, it is used for treating blood stasis, dysmenorrhea, contusion and swelling pain and blood stasis.

[0068] Tangerine peel

[0069] Properties: bitter, pungent, warm, lungs, spleen;

[0070] Effect: regulating qi and invigorating spleen, drying dampness and reducing phlegm, treating qi stagnation in the spleen and stomach, abdominal distension and pain, and cough with much phlegm, and adjusting the properties of other herbs.

[0071] Stretches the tendon grass

[0072] Properties: bitter, pungent, warm, liver, spleen, kidney;

[0073] Effect: dispelling wind and dampness, relaxing muscles and tendons, treating rheumatic pain, joint stiffness and muscle and tendon contracture, and enhancing local blood circulation.

[0074] Amber

[0075] Properties: bitter, pungent, warm, kidney, spleen;

[0076] Effect: tonifying kidney and strengthening yang, astringing essence and reducing urine, warming spleen and stopping diarrhea, treating kidney deficiency and impotence, cold pain in the waist and knees, and spleen and kidney yang deficiency, and auxiliary improvement of muscle weakness.

[0077] Radix Polygoni Multiflori

[0078] Properties: bitter, sweet, astringent, slightly warm, liver, heart, kidney;

[0079] Effect: detoxifying and resolving abscess, tonifying liver and kidney, nourishing blood and dispelling wind, treating scrofula, sores, itching and chronic malaria, and enhancing immunity.

[0080] Radix Astragali

[0081] Properties: sweet, slightly warm, spleen, lung;

[0082] Effect: tonifying qi and ascending yang, reinforcing the defensive aspect and consolidating the exterior, promoting toxin and generating muscle, treating qi deficiency and debility, middle qi and prostration, and chronic ulcer, and promoting tissue repair.

[0083] Angelica

[0084] Properties: sweet, pungent, warm, liver, heart, spleen;

[0085] Effect: tonifying blood and activating blood, regulating menstruation and relieving pain, moistening the intestines and promoting defecation, treating blood deficiency, bruising and injury, and irregular menstruation, and compatibility with Chuanxiong and safflower to enhance the effect of activating blood.

[0086] Cortex Moutan

[0087] Properties: bitter, pungent, slightly cold, heart, liver, kidney;

[0088] Effect: clearing heat and cooling blood, activating blood and resolving stasis, treating warm toxin and rash, hematemesis and metrorrhagia, and injury, balancing the warm nature of the whole prescription and preventing excessive heat and yin.

[0089] Caulis Spatholobi

[0090] Drug properties: bitter, slightly sweet, warm, liver, kidney;

[0091] Effect: blood, tendon, main treatment irregular menstruation, rheumatism and numbness, enhance local blood circulation.

[0092] Potassium sorbate

[0093] Drug properties: chemical preservative, no traditional drug properties;

[0094] Effect: inhibit microbial growth, prolong the shelf life of the preparation, ensure the safety of the drug.

[0095] Purified water

[0096] Drug properties: neutral solvent, no traditional drug properties;

[0097] Effect: dissolve drug ingredients, adjust the concentration of the preparation, facilitate transdermal absorption.

[0098] II. Preparation method

[0099] Extracting essence

[0100] The raw materials of frankincense and myrrh are crushed to a particle size of ≤2 mm and placed in a low-temperature extraction kettle. 8 times the amount of ethanol (60% by volume) is added, and extraction is carried out at 50°C for 3 hours. After filtration, the filtrate is concentrated under reduced pressure to a relative density of 1.20 (60°C). Frankincense essence and myrrh essence are obtained.

[0101] Water decoction and concentration

[0102] Mix the medicinal materials of Szechuan lovage, safflower, panax notoginseng, dried tangerine or orange peel, stretchy grass, psoralea, radix polygoni multiflori, astragalus, angelica, cortex moutan, and morinda officinalis. Soak in 10 times the amount of water for 1 hour, then decoct for 1.5 hours. Filter out the liquid. Add 8 times the amount of water for the second decoction, and decoct for 1 hour. Combine the filtrates from both times.

[0103] Concentrate the filtrate under reduced pressure to a relative density of 1.12 (60°C), and cool to room temperature for use.

[0104] Mix and adjust

[0105] Add frankincense essence, myrrh essence, and concentrated medicinal liquid to the stirring tank in sequence, and stir at a speed of 300 rpm for 10 minutes until uniform.

[0106] Slowly add potassium sorbate (previously dissolved in a small amount of purified water) and the remaining purified water, and continue stirring for 20 minutes until completely dissolved. Adjust the pH value to 6.0.

[0107] Sterilization and packaging

[0108] Filter the mixed solution through a 0.22 μm microporous filter to remove bacteria, and package in brown glass bottles, 50 mL per bottle. Seal and store in the dark.

[0109] III. Application Example

[0110] Case: Patient Li, male, 45 years old, due to long-term work in a crouched position leading to cervical spondylosis, manifested as neck stiffness, shoulder and back pain with upper limb numbness, lasting for 3 months.

[0111] Questioning and positioning

[0112] Through palpation, it was confirmed that the pain points were located in the cervical 4-5 intervertebral space and the right lateral trapezius muscle bundle, and the diagnosis was fascial ligament hyaline degeneration combined with nerve root compression.

[0113] Pre-treatment

[0114] Continuous pressing: press the pain point area with the thumb, the intensity is tolerated by the patient, last for 5 minutes until the local acidification is reduced;

[0115] Palm massage: massage the neck and shoulder muscles with the heel of the palm in a clockwise direction, frequency 60 times / min, last for 5 minutes until the skin is slightly hot.

[0116] Administration

[0117] Take Zhenggu Huolu Zhitong Liquid 10mL, evenly spray on the affected area, gently rub with the finger abdomen for 3 minutes to promote drug absorption;

[0118] Once a day in the morning and evening, 7 days as a course of treatment.

[0119] Observation of curative effect

[0120] On the 3rd day: the patient reported that the stiffness of the neck was reduced, and the frequency of upper limb numbness was decreased;

[0121] On the 7th day: the pain score (VAS) decreased from 7 to 3, the range of motion of the neck increased by 20°, and the shoulder and back pain basically disappeared;

[0122] Follow-up for 1 month: no recurrence, and the quality of life was significantly improved.

[0123] IV. Drug synergy mechanism

[0124] Blood-activating and stasis-removing as the core: the synergistic effect of Olibanum, Myrrh, Chuanqiong, Safflower and Sanqi quickly eliminates local blood stasis and relieves pain.

[0125] Muscle and tendon relaxation as an auxiliary: Strobilanthes, Jiuxueteng enhance the elasticity of fascial ligament and improve joint mobility.

[0126] Reinforcing and repairing as support: Huangqi, Heshouwu and Danggui promote tissue regeneration, and Buguzhi strengthens tendons and bones to prevent recurrence.

[0127] Cold-warm balance as a guarantee: Mudanpi restricts the warm and dry nature of the whole prescription, and Chenpi regulates Qi movement to avoid drug property bias.

[0128] The embodiment realizes the combination of traditional Chinese medicine and modern preparation technology through scientific proportioning and process control, and has significant clinical verification effect and high safety.

[0129] The above merely describes specific embodiments of the present application, but the protection scope of the present application is not limited thereto, any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A bone-setting and meridian-collateral pain-relieving liquid, characterized in that, It is made of the following raw materials with the following weight percentages: Olibanum extract 5%-10%; Myrrh extract 5%-10%; Chuanqiong 8%-12%; Safflower 6%-10%; Sanqi 5%-8%; Tangerine peel 4%-7%; Jingujing 6%-9%; Buguzhi 5%-8%; Heshouwu 4%-6%; Huangqi 8%-12%; Danggui 6%-10%; Mudanpi 5%-8%; Jixueteng 8%-12%; Potassium sorbate 0.1%-0.3%; Purified water is added to 100%.

2. The bone-setting and meridian-collateral activating analgesic liquid according to claim 1, characterized in that: the weight percentages of the raw materials are as follows: olibanum extract 8%, myrrh extract 8%, chuanqiong 10%, safflower 8%, sanqi 6%, tangerine peel 5%, jingujing 7%, buguzhi 6%, heshouwu 5%, huangqi 10%, danggui 8%, mudanpi 6%, jixueteng 10%, potassium sorbate 0.2%, and purified water is added to 100%.

3. The preparation method of the bone-setting and collaterals-moving analgesic liquid as claimed in any one of claims 1-2, characterized in that, It comprises the following steps: (1) Extracting extract: olibanum and myrrh are extracted by low-temperature extraction technology to obtain extract; (2) Water decocting and concentrating: the remaining Chinese herbal medicines are decocted twice with water, the filtrates are combined and concentrated to a relative density of 1.10-1.15; (3) Mixing and dispensing: the olibanum extract, myrrh extract and concentrated liquid are mixed, potassium sorbate and purified water are added, and stirring is performed until uniform; (4) Sterilization and dispensing: the filter sterilization method is used, and the liquid is dispensed in light-proof containers.

4. The method of claim 3, wherein: The temperature of the low-temperature extraction technology is 40-60℃, and the extraction time is 2-4 hours.

5. The method of claim 3, wherein: In the water decocting and concentrating step, the first time, the amount of water added is 8-10 times the total weight of the medicinal materials, and the decoction is performed for 1.5-2 hours; the second time, the amount of water added is 6-8 times the total weight of the medicinal materials, and the decoction is performed for 1-1.5 hours.

6. The use of the bone-setting and collaterals-regulating analgesic solution according to any one of claims 1-2, characterized in that, It is used for preparing an external medicine for treating fascia and ligament injury, joint pain or soft tissue inflammation.

7. Use according to claim 6, characterized in that: The use method of the bone-setting and meridian-collateral activating analgesic liquid comprises the following steps: (1) Inquiry and positioning: confirming the pain site and cause of the patient; (2) Hand examination and palpation: pressing the pain point with the thumb or middle finger of the index finger to perceive the characteristics of fascia and ligament glassy lesions; (3) Pretreatment: continuously pressing the pain point for 5 minutes; massaging the pain point with the palm for 5 minutes until the skin is slightly hot; (4) Administration: spraying the analgesic liquid on the affected area, and gently pressing and rubbing until completely absorbed; (5) Frequency: twice a day, and 7 days as a course of treatment.

8. Use according to any one of claims 6-7, characterized in that: The bone-setting and meridian-collateral activating analgesic liquid is suitable for the auxiliary treatment of cervical spondylosis, lumbar disc herniation, shoulder periarthritis or sports injury.