Three-plug type hematopoietic stem cell infusion device

Abstract

The invention discloses a three-plug type hematopoietic stem cell infusion device, and belongs to the technical field of infusion devices. According to the infusion device, after an infusion pipeline is pretreated through normal saline in a first normal saline bag and a second normal saline bag, stem cell suspension in a stem cell suspension bag is conveyed into the body of a patient through the infusion pipeline; rubber plugs are arranged at the bottoms of the first normal saline bag, the second normal saline bag and the stem cell suspension bag, the bottoms of the multiple rubber plugs are communicated with a first branch pipe, a second branch pipe and a third branch pipe, quick closing switches are arranged on the surfaces of the rubber plugs, the communicating position of the first branch pipe and the second branch pipe is located above the communicating position of the third branch pipe and the second branch pipe, and a dropper is communicated with the bottom of the second branch pipe. The bottom of the dropper is communicated with a filtering device through a transfusion pipeline, the bottom of the filtering device is communicated with an adjusting device through a transfusion pipeline, the bottom of the adjusting device is communicated with a blood return preventing device through a transfusion pipeline, the blood return preventing device is communicated with veins of a patient through a transfusion pipeline, and the surfaces of the rubber plugs are provided with first misplug preventing frames and second misplug preventing frames.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of infusion devices, in particular to a three-plug type hematopoietic stem cell infusion device. BACKGROUND

[0002] The hematopoietic stem cell infusion device is an important medical device for transplantation treatment, which is mainly used for accurately and safely infusing hematopoietic stem cells into the patient's body. Hematopoietic stem cells are "seed cells" of the blood system and can differentiate into various blood cells, which play a key role in the treatment of blood system diseases such as leukemia and aplastic anemia. The infusion device is usually composed of sterile infusion pipeline, filtering device and infusion interface, which can effectively filter impurities and microthrombus, ensure the purity and safety of the infusion process, and its design conforms to the ergonomics, is easy to operate, and medical staff can easily master it, reducing the risk of complications during infusion. In the transplantation process, it provides a reliable "life channel" for the patient, helps the patient to rebuild normal hematopoiesis and immune function, and is an indispensable tool for modern blood disease treatment.

[0003] In the prior art, the pipeline structure of the traditional hematopoietic stem cell infusion device is rough, which cannot meet the needs of efficient and accurate infusion. The interface design of the infusion device is unreasonable, and after being connected to the stem cell suspension bag, it cannot be directly connected to the physiological saline bag. Medical staff have to frequently puncture the physiological saline bag temporarily to dilute or flush the infusion pipeline. This operation not only increases the workload of medical staff, but also easily causes infection risk, destroys the sterile environment, causes physiological saline waste and infusion interruption, affects the continuity and stability of infusion, and brings psychological burden to the patient. In addition, the infusion device adopts a three-plug design, and since the interfaces are similar and multiple, medical staff are easy to confuse during operation. Once misplug, it will cause infusion error, further increase medical risk, and delay treatment opportunity. SUMMARY

[0004] The present application aims to provide a three-plug type hematopoietic stem cell infusion device to solve the problem that the pipeline structure of the traditional hematopoietic stem cell infusion device in the prior art is rough and the interface design is unreasonable, which cannot directly connect the physiological saline bag, so that medical staff have to frequently puncture the physiological saline bag temporarily during infusion, thereby causing the risk of destroying the sterile environment and interrupting the infusion due to frequent puncture during infusion.

[0005] The application provides a three-insertion type hematopoietic stem cell infusion device, which transports the stem cell suspension in a stem cell suspension bag into a patient's body through infusion pipelines after the infusion pipelines are pretreated by physiological saline in a physiological saline bag one and a physiological saline bag two, the bottom of the physiological saline bag one, the physiological saline bag two and the stem cell suspension bag is provided with a rubber plug, a plurality of the rubber plugs are communicated with branch pipes one, branch pipes two and branch pipes three at the bottom, and the surface of each rubber plug is provided with a quick closing switch, the branch pipe one is communicated with the branch pipe two, and the branch pipe two is communicated with the branch pipe three, the branch pipe one is located above the branch pipe two, the bottom of the branch pipe two is communicated with a dropper, the bottom of the dropper is communicated with a filtering device through an infusion pipeline, the bottom of the filtering device is communicated with an adjusting device through an infusion pipeline, the bottom of the adjusting device is communicated with an anti-backflow device through an infusion pipeline, and the anti-backflow device is communicated with a patient's vein through an infusion pipeline; the surface of each rubber plug is provided with an anti-misinsertion rack one and an anti-misinsertion rack two, the inner wall of the anti-misinsertion rack one and the anti-misinsertion rack two is provided with a through slot and an anti-misinsertion slot, the shapes of a plurality of anti-misinsertion slots are different, the inner wall of the anti-misinsertion rack one is provided with a sliding groove one, the anti-misinsertion rack one is provided with an anti-misinsertion baffle and a driving sliding block which are slidably connected to the inner wall of the sliding groove one, the bottom of the anti-misinsertion baffle is fixedly connected with a connecting block, the connecting block is fixed to the top of the driving sliding block, a through hole is formed in the side of the anti-misinsertion baffle, a spring one is fixed to the inner wall of the sliding groove one, the other end of the spring one is fixed to the side of the connecting block, the bottom of the anti-misinsertion rack one is provided with an anti-misinsertion head, the shapes of a plurality of anti-misinsertion heads correspond to the anti-misinsertion slots on the top of the anti-misinsertion heads, a sliding groove two is formed in the surface of the anti-misinsertion head, a bottle plug piercer is arranged in the inner wall of the anti-misinsertion head, a pushing block is fixed to the surface of the bottle plug piercer, the pushing block is slidably arranged in the inner wall of the sliding groove two, and the bottom of the bottle plug piercer is communicated with the branch pipes one, the branch pipes two and the branch pipes three.

[0006] Further, the quick closing switch comprises a switch body, a sliding groove three is arranged in the switch body, a control piece is slidably connected to the inner wall of the sliding groove three, a pressing cover is fixed to one side of the control piece, a push rod is fixed to the other side of the control piece, the push rod slides in the inner wall of the sliding groove three, a pressing block is fixed to one end of the push rod, plastic shells one and two are arranged on the surfaces of the branch pipes one, two and three, plastic plates are fixed to one side of the plastic shells one and two, the plastic plates are arranged on one side of the switch body, guide grooves one, two, three and four are arranged on one side of the control piece, the bottom of the inner wall of the guide groove one is higher than the bottom of the inner wall of the guide groove two, the bottom of the inner wall of the guide groove two is higher than the bottom of the inner wall of the guide groove three, the guide grooves three to four are upward, the bottom of the inner wall of the guide groove four is higher than the bottom of the inner wall of the guide groove one, a rotating shaft is rotatably connected to the inner wall of the sliding groove three, connecting rods one and two are fixed to the surface of the rotating shaft, a spring three is fixed to the top of the connecting rod two, the other end of the spring three is fixed to the bottom of the connecting rod one, a driving shaft is fixed to the bottom of the connecting rod one and arranged in the inner wall of the guide groove one. In the prior art, the traditional hematopoietic stem cell infusion device has obvious defects in the design of the liquid outlet end of the infusion system. The liquid outlet end is usually located at a high position of the infusion system and is the starting port of the liquid flow from the storage container. However, many infusion devices fail to provide a directly controlled valve at this critical position, or the operation mechanism of the valve is relatively complex and the closing process is cumbersome. Such a design makes it difficult for medical staff to quickly control the liquid outflow through the valve when a quick pause of infusion is needed, and only other temporary measures can be taken, which may cause potential medical risks. In addition, the complicated valve operation may prolong the infusion preparation time and reduce the infusion efficiency, especially in emergency situations, which may delay the treatment opportunity. In view of the above problems, the quick closing switch structure is adopted. When it is necessary to close the pipeline, the pressing cover is pressed, which drives the control piece to move. Due to the action of the spring three, the driving shaft located in the inner wall of the guide groove one slides into the guide groove two, and then the driving shaft slides into the guide groove three and is clamped by the assembly for limiting. At this time, the pressing block is driven to push between the plastic shells one and two to press the pipeline. The pipeline is clamped and closed, so that the liquid outlet end is closed. The safety, accuracy and efficiency of the infusion process are significantly improved. Medical staff can quickly and accurately control the liquid outflow, avoid potential risks such as backflow and air entry caused by inconvenient operation, ensure the stability and continuity of the infusion process, simplify the valve operation process, shorten the infusion preparation time, improve the infusion efficiency, especially in emergency situations, which can save valuable treatment time for patients and reduce the risk of delay. In addition, the optimized design can also reduce the operation burden of medical staff, improve the smoothness and reliability of the overall medical operation, and provide patients with a safer and more efficient infusion treatment experience.

[0007] Further, the filter device comprises a liquid collector, the inner wall of the liquid collector is fixed with a partition plate one, one side of the liquid collector is fixed with a filter ring, the inner wall of the filter ring is provided with a coarse filter layer, one side of the coarse filter layer is provided with a fine filter layer, one side of the fine filter layer is provided with a support layer, one side of the filter ring is fixed with a liquid outlet, and the inner wall of the liquid outlet is fixed with a partition plate two. In the prior art, the filter device of the traditional infusion device has many defects, which seriously affects the safety and effectiveness of infusion, the filtering precision is not high enough, and the small impurities, blood clots or cell fragments in the infusion liquid cannot be effectively intercepted, these impurities entering the patient's body can cause adverse reactions such as blood vessel blockage, allergic reaction, etc., which poses a potential threat to the patient's health, secondly, the structural design of the filter device is not reasonable enough, which can easily cause liquid to pass through not smoothly, increase the infusion resistance, affect the infusion speed and uniformity, especially when infusing viscous hematopoietic stem cell suspension, the problem is more prominent, in addition, the material stability of part of the filter device is not enough, which can cause chemical reaction when infusing for a long time or contacting some drugs, release harmful substances, further affect the quality of the infusion liquid, these problems not only increase the operation difficulty of medical staff, but also delay the treatment opportunity of patients, reduce the overall effect of infusion treatment, in view of such problems, the layered filter device is adopted in the application, the filter device is composed of a coarse filter layer, a fine filter layer and a support layer, the coarse filter layer is woven by fibers with large pore size, which can effectively intercept larger particle impurities such as blood clots and tissue fragments, the fine filter layer is composed of nano-level microporous membrane, which can accurately filter small impurities and ensure smooth passage of stem cells, and the support layer is made of high-strength polymer material, which provides structural support for the entire filter screen and prevents deformation under the action of liquid pressure, so as to significantly improve the safety and effectiveness of the infusion process, the improvement of filtering precision can effectively intercept small impurities, blood clots or cell fragments in the infusion liquid, reduce the occurrence of adverse reactions in the patient's body, such as blood vessel blockage, allergic reaction, etc., so as to reduce the potential threat to the patient's health, the optimization of the structural design will ensure smooth passage of liquid, reduce infusion resistance, improve infusion speed and uniformity, especially when infusing viscous hematopoietic stem cell suspension, the effect is more obvious, in addition, the improvement of material stability will avoid chemical reaction when infusing for a long time or contacting some drugs, ensure the quality of the infusion liquid, the solution of these problems will reduce the operation difficulty of medical staff, reduce treatment delay, improve the overall effect of infusion treatment, and provide safer and more effective infusion treatment for patients.

[0008] Further, the anti-backflow device comprises an anti-backflow device body, a spherical groove is formed in the inner wall of the anti-backflow device body, a strip-shaped fixed block is fixed to the inner wall of the spherical groove, a support rod is fixed to one side of the strip-shaped fixed block, a spherical support is fixed to one side of the support rod, a sliding groove four is formed in one side of the spherical support, a sliding column one is slidably connected to the inner wall of the sliding groove four, a sealing cap is fixed to one side of the sliding column one, and a sliding column two is fixed to the other side of the sliding column one, a sliding groove five is formed in one end of the support rod, the sliding column two slides in the inner wall of the sliding groove five, a spring four is fixed to one side of the sliding column two, and the other end of the spring four is fixed to the inner wall of the sliding groove four. When infusion is performed, the liquid is pushed, and then pressed to make contact, and when the liquid flows down completely, the spring four is rebounded to block the upper port, so that the backflow of blood cannot flow back, effectively preventing the backflow of blood to the infusion pipeline or storage container during infusion, avoiding blood coagulation caused by backflow of blood, thereby reducing the risk of blockage, ensuring the continuity and stability of the infusion process. Secondly, the anti-backflow device can reduce the opportunity of blood contacting the external environment, reduce the risk of infection, and further protect the safety of patients. In addition, it can also reduce the discomfort or complications of patients caused by backflow of blood, improve the infusion experience of patients. For medical staff, the anti-backflow device simplifies the operation process, reduces the increased workload caused by handling backflow problems, improves work efficiency, significantly improves the safety, reliability and convenience of the infusion process, and provides better protection for patients and medical staff.

[0009] Further, the adjusting device comprises an adjuster body, a component groove is formed in one side of the adjuster body, a fixed shaft is fixed to the inner wall of the component groove, a rotating member is rotatably connected to the surface of the fixed shaft, a dial adjustment switch is fixed to the surface of the rotating member, an arrow indication mark is formed in one side of the dial adjustment switch, a compression member is fixed to the surface of the rotating member, and size prompt marks are formed in one side of the adjuster body. When adjusting, the position and shape of the compression member relative to the rotating member make the compression member quantitatively press and clamp the pipeline during adjustment. The adjusting device realizes precise control and convenient adjustment of the infusion speed. By dialing the adjustment switch, medical staff can quickly adjust the infusion speed according to the specific condition of the patient, and intuitively understand the current speed state through the arrow indication mark. At the same time, the compression member ensures the stability after adjustment, prevents accidental change of speed, and provides clear speed reference for medical staff through the size prompt marks, further improves the accuracy and safety of operation, not only improves the controllability of the infusion process, but also reduces the risk of complications caused by improper speed adjustment, provides a safer and more accurate infusion treatment experience for patients.

[0010] Further, one side of the anti-misplug frame is rotatably connected with a rotating shaft, a rotating circular groove is formed through the anti-misplug frame from one side to the other side, a square groove is formed in the inner wall of the rotating circular groove, the rotating shaft is arranged in the inner wall of the rotating circular groove, a pushing block is fixed to one end of the rotating shaft, and a clamping block is fixed to the other end of the rotating shaft. Through the above design, the anti-misplug structure can be added to the existing infusion bag port without pre-installation when the infusion bag leaves the factory. This flexible installation method can significantly improve the safety and reliability of the infusion process, effectively avoid infusion errors or pipeline blockage caused by interface misplug, reduce medical risks, and at the same time, it provides greater flexibility for medical institutions, and can equip the existing infusion bag with anti-misplug function at any time according to actual needs, without the need to replace or customize special infusion bags, saving costs and improving resource utilization, further optimizing the infusion operation process, and ensuring patient safety.

[0011] Further, a vertical limiting block is arranged on the top of the pushing block, a horizontal limiting block is arranged on the bottom of the pushing block, the vertical limiting block is fixed to one side of the anti-misplug frame, and the horizontal limiting block is fixed to one side of the anti-misplug frame. Through the arrangement of the vertical limiting block and the horizontal limiting block, the operation of the anti-misplug structure during disassembly can be more accurate, the rotating range of the rotating shaft can be effectively limited, and the rotating shaft can be prevented from exceeding the predetermined angle. This design avoids damage or failure of the structure caused by improper operation, improves the stability and reliability of the anti-misplug device, and at the same time, the arrangement of the limiting block simplifies the installation and disassembly process, reduces the operation difficulty, and enables medical staff to quickly and accurately complete the assembly or replacement of the anti-misplug structure, further improving the efficiency and safety of infusion operation, and providing more reliable protection for medical operation.

[0012] Further, two clamping pieces one are fixed to one side of the plastic shell, a clamping groove one is fixed to one side of the switch body, the clamping piece one is clamped in the inner wall of the clamping groove one, two clamping pieces two are fixed to one side of the plastic shell two, two clamping grooves two are fixed to one side of the switch body, and the clamping piece two is clamped in the inner wall of the clamping groove two. Through the above design, the switch device can be flexibly installed at any position of the pipeline without pre-installation of the pipeline when leaving the factory. This self-defining installation method provides greater convenience and flexibility for users, and can freely select the best position of the switch according to actual needs and operation habits. At the same time, the clamping of the clamping piece and the clamping groove ensures the stability of the switch on the pipeline, avoids loosening or falling of the switch due to movement or external force of the pipeline.

[0013] Further, the anti-misplug groove at the bottom of the physiological saline bag one is circular, the anti-misplug groove at the bottom of the physiological saline bag two is rectangular, and the anti-misplug groove at the bottom of the stem cell suspension bag is trapezoidal. A plurality of anti-misplug grooves satisfy:

[0014]

[0015] wherein w represents the width of the rectangle, h represents the height of the rectangle, r represents the radius of the circle, a represents the upper base of the trapezoid, b represents the lower base of the trapezoid, and ht represents the height of the trapezoid. Through the above constraints, it is ensured that the anti-misplug structure can work stably and reliably on infusion bag ports of different shapes and sizes. This design avoids the problem of anti-misplug function failure caused by mismatched interface shapes or sizes, enhances the universality and adaptability of the device, effectively prevents misplug regardless of the specific specifications of the infusion bag, thereby improving the safety and reliability of the infusion process and reducing medical risks caused by misplug.

[0016] Further, the coarse filter layer is woven with polyester fibers, the pore size of the coarse filter layer is 100-200 mu m, the fine filter layer is made of polycarbonate material, the pore size of the fine filter layer is 5-40 mu m, the support layer is made of polypropylene material, the pore size of the support layer is 500-1200 mu m, and the thickness of the support layer is 0.5-1.5 mm. By adopting the three-layer structure design of different materials and pore sizes, the coarse filter layer, fine filter layer and support layer work together to achieve efficient and precise filtering effect. The coarse filter layer can effectively intercept larger particulate impurities, the fine filter layer can precisely filter small impurities and allow stem cells to pass smoothly, and the support layer provides stable support for the entire filter screen to prevent deformation. This design not only improves the filtering precision and stability, but also ensures the purity of the infusion solution and the smoothness of the infusion process, significantly improving the safety and reliability of the infusion.

[0017] Compared with the prior art, the beneficial effects of the present application are:

[0018] Firstly, the three-plug type hematopoietic stem cell infusion device significantly improves the safety, efficiency and stability of the infusion process, reduces the work burden of medical staff, makes the infusion operation more convenient and smooth, avoids the risk of infection and damage to the sterile environment caused by frequent puncture, reduces the waste of physiological saline, and at the same time, the anti-misplug structure eliminates the risk of misplug, ensures the accuracy of infusion, avoids delay of treatment opportunity, guarantees the continuity and stability of the infusion process, and reduces the psychological burden of patients, providing patients with a safer and more reliable treatment experience, and helping to improve the overall success rate of hematopoietic stem cell transplantation and patient rehabilitation effect.

[0019] Secondly, the present application significantly improves the safety, accuracy and efficiency of the infusion process by introducing a quick closing switch. Medical staff can quickly and accurately control the outflow of liquid, avoiding potential risks such as backflow and air entry caused by inconvenient operation, ensuring the stability and continuity of the infusion process. At the same time, simplifying the valve operation process can shorten the infusion preparation time and improve the infusion efficiency. Especially in emergency situations, it can save valuable treatment time for patients and reduce the risk of delay. In addition, the optimized design can also reduce the operation burden of medical staff and improve the smoothness and reliability of the overall medical operation, providing patients with a safer and more efficient infusion treatment experience.

[0020] Thirdly, in the present application, the safety and effectiveness of the infusion process are significantly improved by introducing a layered filtering device. The improvement of filtering precision can effectively intercept small impurities, blood clots or cell fragments in the infusion liquid, reducing the occurrence of adverse reactions in patients, such as blood vessel blockage and allergic reaction, thereby reducing the potential threat to patients' health. The optimized structure design will ensure smooth liquid passage and reduce infusion resistance, improving infusion speed and uniformity. Especially when infusing viscous hematopoietic stem cell suspension, the effect is more obvious. In addition, the improvement of material stability will avoid chemical reaction when infusing for a long time or contacting certain drugs, ensuring the quality of the infusion liquid. The solution of these problems will reduce the operation difficulty of medical staff, reduce treatment delay and improve the overall effect of infusion therapy, providing patients with safer and more effective infusion therapy.

[0021] Fourthly, the present application effectively prevents blood from flowing back to the infusion pipeline or storage container during the infusion process by introducing an anti-backflow device, avoiding blood coagulation caused by backflow, thereby reducing the risk of blockage and ensuring the continuity and stability of the infusion process. Secondly, the anti-backflow device can reduce the opportunity of blood contacting the external environment and reduce the risk of infection, further protecting patient safety. In addition, it can also reduce patient discomfort or complications caused by backflow and improve patient infusion experience. For medical staff, the anti-backflow device simplifies the operation process, reduces the increased workload caused by handling backflow problems, improves work efficiency, significantly improves the safety, reliability and convenience of the infusion process, and provides better protection for patients and medical staff.

[0022] Fifthly, in the present application, the precise control and convenient adjustment of the infusion speed are realized by introducing the precise adjustment device. By turning the adjustment switch, the medical staff can quickly adjust the infusion speed according to the specific condition of the patient, and intuitively understand the current speed state through the arrow indication mark. At the same time, the pressing part ensures the stability after adjustment, prevents the speed from changing accidentally, and the size prompt mark provides a clear speed reference for the medical staff, further improving the accuracy and safety of operation, not only improving the controllability of the infusion process, but also reducing the risk of complications caused by improper speed adjustment, providing the patient with a safer and more precise infusion treatment experience. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the specific embodiments or the prior art description will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the present application, and those skilled in the art can also obtain other drawings according to these drawings without creative labor.

[0024] Figure 1 It is a three-plug type hematopoietic stem cell infusion device;

[0025] Figure 2 It is an explosion view of a three-plug type hematopoietic stem cell infusion device anti-misplug structure;

[0026] Figure 3 It is a sectional view of a three-plug type hematopoietic stem cell infusion device anti-misplug structure;

[0027] Figure 4 It is an explosion view of a three-plug type hematopoietic stem cell infusion device quick closing switch structure;

[0028] Figure 5 It is an explosion view of a three-plug type hematopoietic stem cell infusion device quick closing switch drive;

[0029] Figure 6 It is an explosion view of a three-plug type hematopoietic stem cell infusion device quick closing switch convenient disassembly structure;

[0030] Figure 7 It is an explosion view of a three-plug type hematopoietic stem cell infusion device filter device;

[0031] Figure 8 It is an explosion view of a three-plug type hematopoietic stem cell infusion device filter device liquid collector;

[0032] Figure 9 It is a sectional view of a three-plug type hematopoietic stem cell infusion device anti-backflow structure;

[0033] Figure 10 A three-dimensional structural diagram of a precision adjustment structure for a three-pronged hematopoietic stem cell infusion device;

[0034] Figure 11 A cross-sectional view of the precise adjustment structure of a three-pronged hematopoietic stem cell infusion device;

[0035] Figure 12 for Figure 2 Enlarged view of point A in the middle;

[0036] Figure 13 for Figure 3 Enlarged view of point B in the middle;

[0037] Figure 14 for Figure 4 Enlarged view of point C in the middle;

[0038] Figure 15 for Figure 4 Enlarged view of point D in the middle.

[0039] Figure label:

[0040] 1, physiological saline bag one; 101, physiological saline bag two; 102, stem cell suspension bag; 103, anti-misplug rack one; 104, anti-misplug rack two; 105, anti-misplug plug; 106, through slot; 107, anti-misplug slot; 108, sliding slot one; 109, anti-misplug baffle; 110, driving sliding block; 111, connecting block; 112, through hole; 113, spring one; 114, sliding slot two; 115, bottle plug piercer; 116, pushing block; 118, rubber plug; 119, branch pipe one; 120, branch pipe two; 121, branch pipe three; 2, switch main body; 201, sliding slot three; 202, control piece; 203, pressing cover; 204, pushing rod; 205, pressing block; 206, plastic shell one; 207, plastic shell two; 208, plastic plate; 209, guide slot one; 210, guide slot two; 211, guide slot three; 212, guide slot four; 213, spring two; 214, rotating shaft; 215, connecting rod one; 216, connecting rod two; 217, spring three; 218, driving shaft; 3, liquid collector; 301, partition one; 302, filter ring; 303, coarse filter layer; 304, fine filter layer; 305, support layer; 306, liquid outlet device; 307, partition two; 4, anti-backflow device main body; 401, spherical groove; 402, support rod; 403, strip-shaped fixing block; 404, spherical support piece; 405, sliding slot four; 406, sliding column one; 407, sealing cap; 408, sliding column two; 409, spring four; 410, sliding slot five; 5, regulator main body; 501, assembly slot; 502, fixing shaft; 503, rotating piece; 504, dial adjustment switch; 505, pressing piece; 506, size prompt mark; 507, arrow indication mark; 6, rotating circular groove; 601, rotating shaft; 602, dial block; 603, clamping block; 604, square groove; 701, vertical limiting block; 702, horizontal limiting block; 8, clamping piece one; 801, clamping piece two; 802, clamping groove one; 803, clamping groove two. DETAILED DESCRIPTION

[0041] The technical solutions of the present application will be described clearly and completely below in conjunction with the drawings. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments.

[0042] The components of the embodiments of the present application generally described and shown in the drawings herein can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed application, but merely represents selected embodiments of the present application.

[0043] All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without creative labor fall within the scope of protection of the present application. Embodiment 1:

[0045] The following description is provided in relation to the accompanying drawings Figures 1 to 15As shown, the embodiment of the present application provides a three-insertion type hematopoietic stem cell infusion device, which transports the stem cell suspension in the stem cell suspension bag 102 into the patient's body through the infusion pipeline after the infusion pipeline is pretreated by the physiological saline in the physiological saline bag one 1 and the physiological saline bag two 101, the bottom of the physiological saline bag one 1, the physiological saline bag two 101 and the stem cell suspension bag 102 is provided with a rubber plug 118, a plurality of the rubber plug 118 is communicated with a branch pipe one 119, a branch pipe two 120 and a branch pipe three 121 at the bottom, and the surface is provided with a quick closing switch, the branch pipe one 119 and the branch pipe two 120 are communicated above the branch pipe three 121 and the branch pipe two 120, the bottom of the branch pipe two 120 is communicated with a dropper, the bottom of the dropper is communicated with a filtering device through the infusion pipeline, the bottom of the filtering device is communicated with an adjusting device through the infusion pipeline, the bottom of the adjusting device is communicated with an anti-backflow device through the infusion pipeline, and the anti-backflow device is communicated with the patient's vein through the infusion pipeline; a plurality of the rubber plug 118 is provided with an anti-misinsertion rack one 103 and an anti-misinsertion rack two 104 on the surface, the inner wall of the anti-misinsertion rack one 103 and the anti-misinsertion rack two 104 is provided with a through slot 106 and an anti-misinsertion slot 107, a plurality of the anti-misinsertion slot 107 is different in shape, the inner wall of the anti-misinsertion rack one 103 is provided with a sliding slot one 108, the anti-misinsertion rack one 108 is slidably connected with an anti-misinsertion baffle 109 and a driving sliding block 110, the bottom of the anti-misinsertion baffle 109 is fixedly connected with a connecting block 111, the connecting block 111 is fixed to the top of the driving sliding block 110, one side of the anti-misinsertion baffle 109 is provided with a through hole 112, the inner wall of the sliding slot one 108 is fixedly connected with a spring one 113, the other end of the spring one 113 is fixed to one side of the connecting block 111, a plurality of the anti-misinsertion rack one 103 is provided with an anti-misinsertion head 105 at the bottom, a plurality of the anti-misinsertion head 105 is corresponding in shape to the anti-misinsertion slot 107 at the top, the surface of the anti-misinsertion head 105 is provided with a sliding slot two 114, the inner wall of the anti-misinsertion head 105 is provided with a bottle plug piercer 115, the surface of the bottle plug piercer 115 is fixedly connected with a pushing block 116, the pushing block 116 is slidably arranged in the sliding slot two 114, and the bottom of a plurality of the bottle plug piercer 115 is communicated with the branch pipe one 119, the branch pipe two 120 and the branch pipe three 121.In the prior art, the pipeline structure of the traditional hematopoietic stem cell infusion device is rough, which cannot meet the needs of efficient and accurate infusion. The interface design of the infusion device is unreasonable. After being connected to the stem cell suspension bag, the infusion device cannot be directly connected to the physiological saline bag. Medical staff have to frequently puncture the physiological saline bag temporarily to dilute or flush the infusion pipeline. Such operation not only increases the work burden of medical staff, but also easily causes infection risk, destroys the sterile environment, causes physiological saline waste and infusion interruption, affects the continuity and stability of infusion, and causes psychological burden to patients. In addition, the infusion device adopts a three-plug design. Since the interfaces are similar, medical staff are prone to confusion during operation. Once misplug, it will cause infusion error, further increase medical risk, delay treatment opportunity. In view of such problems, the three-plug anti-misplug structure is adopted. In the initial stage, the switch main body 2 at the bottom of the physiological saline bag 1, the switch main body 2 at the bottom of the physiological saline bag 101 and the switch main body 2 at the bottom of the stem cell suspension bag 102 and the regulator are all in the closed state. In the infusion preparation stage, the switch main body 2 at the bottom of the physiological saline bag 101 and the regulator are first opened, the physiological saline bag 101 is connected, the physiological saline in the physiological saline bag 101 is pre-charged to the entire infusion pipeline to wet the inner wall of the pipeline and discharge air. After sufficient pre-charging, the regulator is closed, the switch main body 2 at the bottom of the physiological saline bag 1 is opened, the physiological saline bag 101 is squeezed, and the physiological saline is pre-charged to the branch pipe 1 19. After that, the switch main body 2 at the bottom of the physiological saline bag 1 is closed, the switch main body 2 at the bottom of the stem cell suspension bag 102 is opened, the physiological saline bag 101 is squeezed, and the physiological saline is pre-charged to the branch pipe 3 121. After that, the switch main body 2 at the bottom of the physiological saline bag 101 is closed, the physiological saline bag 1 and the stem cell suspension bag 102 are connected to the infusion device, and after being connected to the patient's venous end, the regulator is opened. The stem cell suspension in the stem cell suspension bag 102 is filtered through the filter device and the anti-backflow device, and the hematopoietic stem cell infusion can be started. In the connection stage of the physiological saline bag 1, the physiological saline bag 101 and the stem cell suspension bag 102, since the shapes of the anti-misplug grooves 107 at the bottoms of the physiological saline bag 1, the physiological saline bag 101 and the stem cell suspension bag 102 correspond to the shapes of the anti-misplug heads 105 at the bottoms of the physiological saline bag 1, the physiological saline bag 101 and the stem cell suspension bag 102, the anti-misplug heads 105 cannot be inserted into the anti-misplug grooves 107 if the correspondence is wrong. Only when the correspondence is correct, the anti-misplug heads 105 can be inserted. After being inserted, the driving slide 110 drives the anti-misplug baffle 109 to move, so that the through hole 112 moves to allow the bottle plug piercer 115 to be inserted into the rubber plug 118. Then, the pushing block 116 pushes the bottle plug piercer 115 to be inserted into the rubber plug 118.

[0046] In existing infusion sets, traditional hematopoietic stem cell infusion sets typically consist of infusion tubing, filters, and connectors. The infusion tubing is used to safely deliver hematopoietic stem cells from the storage container into the patient's venous system. Its material needs to have good biocompatibility to avoid damaging the cells or causing adverse reactions. The filter plays a crucial role, effectively removing platelets, red blood cell fragments, and other tiny particulate impurities that may mix with the hematopoietic stem cell suspension, ensuring that the cell components infused into the patient are pure and meet transplantation requirements. The connectors are used to stably connect the infusion set to the hematopoietic stem cell storage container and the patient's infusion route. Traditional hematopoietic stem cell infusion sets are designed with ease of operation and safety in mind. Through strict aseptic processing and quality control, they provide reliable equipment support for hematopoietic stem cell transplantation surgery, helping patients successfully complete the infusion process and thus laying the foundation for the reconstruction of hematopoietic function.

[0047] This invention's three-insertion hematopoietic stem cell infusion set effectively solves the problems of rough tubing construction, unreasonable interface design, and easy misinsertion in traditional infusion sets through a unique structural design. The infusion set has rubber stoppers at the bottom of both the saline bag and the stem cell suspension bag, with the bottom of the stoppers connected to branch tubes and equipped with quick-closing switches. Its core innovation lies in its anti-misinsertion structure, which uses various shaped anti-misinsertion slots and plugs to ensure that only the correctly matched bags can be connected to the infusion set, avoiding the risk of misinsertion. During infusion, the saline bag is first used to pre-fill the infusion tubing, moistening the inner wall and expelling air. Then, the stem cell suspension bag is connected, and after passing through a filtration device and an anti-backflow device, the stem cell suspension is accurately infused into the patient. This design not only improves the efficiency and accuracy of infusion but also reduces the workload of medical staff, lowers the risk of infection, and ensures the continuity and stability of infusion, providing patients with a safer and more reliable treatment experience.

[0048] In this embodiment, the beneficial effects of the three-insertion hematopoietic stem cell infusion set compared with those of a traditional infusion set were verified. The verification process involved real-time acquisition of tubing pressure fluctuation data using a high-precision digital pressure sensor integrated directly into the middle section of the infusion tubing. The sensor was connected to a data acquisition instrument and recorded pressure changes at a sampling frequency of 1 kHz. The residual amount of physiological saline was measured using an electronic analytical balance to determine the mass difference of the saline bag before and after infusion. Microbial contamination rate was assessed by sampling at the tubing interface using the contact dish method. After 48 hours of incubation at 37°C, a colony counter was used to count the CFU / cm³. 2 The operation time is manually started and stopped by a dual-channel timer, the consistency of the infusion flow rate is monitored by an ultrasonic flow meter, and the psychological score data is statistically analyzed after being independently filled out by medical staff and patients based on a standardized scale. All instruments are calibrated and comply with the ISO 13485 medical device testing standard.

[0049]

[0050]

[0051] In combination with the above verification process data, the three-plug type hematopoietic stem cell infusion device significantly improves the safety, efficiency and stability of the infusion process, reduces the work burden of medical staff, makes the infusion operation more convenient and smooth, avoids the risk of infection and damage to the sterile environment caused by frequent puncture, reduces the waste of physiological saline, and at the same time, the anti-misplug structure eliminates the risk of misplug, ensures the accuracy of infusion, avoids the delay of treatment opportunity, guarantees the continuity and stability of the infusion process, and reduces the psychological burden of patients, providing patients with a safer and more reliable treatment experience, and helping to improve the overall success rate of hematopoietic stem cell transplantation and patient rehabilitation effect. Specific embodiment 2:

[0053] In this embodiment, based on the comparison of the traditional hematopoietic stem cell infusion device mentioned in embodiment 1, by comparing the traditional infusion device with the improved infusion device equipped with a quick closing switch, the improvement in safety (anti-backflow, anti-air entry), accuracy (flow rate control) and efficiency (operation time, emergency response) is verified: METTLER TOLEDO ME204 electronic balance (0.1 mg precision) is used to measure the backflow liquid volume, the reverse flow of the verification group is reduced from 2.3±0.5mL to 0.1±0.05mL (improved by 95.7%), Phantom VEO 410 high-speed camera is used to capture the pipeline dynamics, the verification group completely eliminates bubble formation (4.2±1.1 times in 10 infusions in the control group), Siemens SITRANS FUE010 ultrasonic flowmeter is used to monitor the flow rate fluctuation, the standard deviation of the flow rate of the verification group is reduced from 0.35±0.08mL / min to 0.08±0.02mL / min (target deviation rate optimization 77.1%), the operation time is recorded by GENEQ GT-801 timer, the valve opening time of the verification group is shortened from 8.2±1.5 seconds to 1.3±0.3 seconds (improved by 84.1%), the emergency interruption response time is compressed from 5.6±1.2 seconds to 0.5±0.1 seconds (improved by 91.1%), and the heart rate variability of medical staff is monitored by Empatica E4 physiological signal instrument, the HRV of the verification group is increased from 38.5±7.2ms to 61.3±9.5ms (stress reduction 58.3%), and the physiological saline waste is reduced by 70.6% (the residual amount measured by the electronic balance is reduced from 24.8±2.9g to 7.3±1.1g), and the patient satisfaction score is increased from 2.9±0.7 to 4.6±0.3 (standardized questionnaire statistics).

[0054]

[0055]

[0056] In combination with the above verification process data, it is concluded that the introduction of the quick closing switch significantly improves the safety, accuracy and efficiency of the infusion process. Medical staff can quickly and accurately control the outflow of liquid, avoid potential risks such as backflow and air entry caused by inconvenient operation, and ensure the stability and continuity of the infusion process. At the same time, simplifying the valve operation process can shorten the infusion preparation time and improve the infusion efficiency. Especially in emergency situations, it can save valuable treatment time for patients and reduce the risk of delay. In addition, the optimized design can also reduce the operation burden of medical staff and improve the smoothness and reliability of the overall medical operation, providing patients with a safer and more efficient infusion treatment experience. Specific embodiment 3:

[0058] In this embodiment, based on the comparison of the traditional hematopoietic stem cell infusion device mentioned in embodiment 1, the performance of the three-insert hematopoietic stem cell infusion device with three-layer filter device (coarse filter layer 50 μm→ fine filter layer 10 μm→ support layer 5 μm) is verified: under the constant pressure of 100 kPa, 500 mL of artificial simulated suspension (containing 0.5% polystyrene microspheres 1-100 μm simulating cell fragments, 0.1% fibrinogen simulating blood clots, and 1% hydroxyethyl cellulose adjusting viscosity to 50 mPa·s) is infused into the verification group (three-layer device) and the control group (single-layer 50 μm device), respectively. The concentration of 1-10 μm and 10-50 μm residual particles (pieces / mL) in the filtrate is quantitatively analyzed using a laser particle size analyzer (Malvern Mastersizer 3000), and the morphology of the retained material is observed by electron microscopy (Hitachi SU3500) to calculate the blood clot interception rate. At the same time, the infusion speed (mL / min) and resistance peak (kPa) of 200 mL of viscous suspension are recorded in real time using an electronic flowmeter (Cole-Parmer EW-32707-10) and a pressure sensor (Honeywell 26PC), and further infusion of 10 6 umbilical cord blood stem cell-containing suspension is carried out, and the cell survival rate (%) of the filtrate is detected by flow cytometry (BD FACSCanto II) combined with PI / Annexin V double staining method. Finally, the device is soaked in 5% ethanol solution for 24 hours, and the concentration of dissolved plasticizer (such as DEHP) (μg / L) is analyzed by high performance liquid chromatography (Agilent 1260).

[0059]

[0060] In combination with the above verification process data, it is concluded that the introduction of the layered filtering device significantly improves the safety and effectiveness of the infusion process, the improvement of filtering precision can effectively intercept the small impurities, blood clots or cell fragments in the infusion solution, reduce the occurrence of adverse reactions in the patient's body, such as blood vessel occlusion, allergic reaction, etc., thereby reducing the potential threat to the patient's health, the optimization of the structure design will ensure the smooth passage of the liquid, reduce the infusion resistance, improve the infusion speed and uniformity, especially when infusing viscous hematopoietic stem cell suspension, the effect is more obvious, in addition, the improvement of material stability will avoid chemical reaction when infusing for a long time or contacting some drugs, ensure the quality of the infusion solution, the solution of these problems will reduce the operation difficulty of medical staff, reduce the treatment delay, improve the overall effect of infusion therapy, and provide safer and more effective infusion therapy for patients.

[0061] The working principle of the present application is:

[0062] In the initial stage, the switch body 2 at the bottom of the physiological saline bag 1, the switch body 2 at the bottom of the physiological saline bag 2 101 and the switch body 2 at the bottom of the stem cell suspension bag 102 and the regulator are all in the closed state, in the infusion preparation stage, the switch body 2 at the bottom of the physiological saline bag 2 101 and the regulator are first opened, the physiological saline bag 2 101 is connected, the physiological saline in the physiological saline bag 2 101 is pre-filled to the whole infusion pipeline to wet the inner wall of the pipeline and discharge air, after sufficient pre-filling, the regulator is closed, the switch body 2 at the bottom of the physiological saline bag 1 is opened, the physiological saline bag 2 101 is squeezed, after the physiological saline in the physiological saline bag 2 101 is fully pre-filled to the branch pipe 1 119, the switch body 2 at the bottom of the physiological saline bag 1 is closed, the switch body 2 at the bottom of the stem cell suspension bag 102 is opened, the physiological saline bag 2 101 is squeezed, after the branch pipe 3 121 is fully pre-filled, the switch body 2 at the bottom of the physiological saline bag 2 101 is closed, the physiological saline bag 1 and the stem cell suspension bag 102 are connected to the infusion device, after being connected to the patient's venous end, the regulator is opened, the stem cell suspension in the stem cell suspension bag 102 is filtered through the filtering device and the anti-backflow device, and then the hematopoietic stem cell infusion can be started, in the connection stage of the physiological saline bag 1, the physiological saline bag 2 101 and the stem cell suspension bag 102, since the shapes of the anti-misplug grooves 107 at the bottoms of the physiological saline bag 1, the physiological saline bag 2 101 and the stem cell suspension bag 102 all correspond to the shapes of the anti-misplug heads 105 at the bottoms of the physiological saline bag 1, the physiological saline bag 2 101 and the stem cell suspension bag 102, if the correspondence is wrong, the anti-misplug head 105 cannot be inserted into the anti-misplug groove 107, only the correct correspondence can be inserted, after being inserted, the driving slider 110 is pushed to drive the anti-misplug baffle 109 to move, so that the through hole 112 moves to make the bottle plug piercer 115 insert the rubber plug 118, then the pushing block 116 is pushed to make the bottle plug piercer 115 insert the rubber plug 118, when it is necessary to close the pipeline, the pressing cover 203 is pressed, at this time, the pressing cover 203 drives the control piece 202 to move, under the action of the spring 3 217, the driving shaft 218 in the inner wall of the guide groove 1 209 slides into the guide groove 2 210, then the driving shaft 218 slides into the guide groove 3 211 and is clamped by the assembly to be limited, at this time, the pressing block 205 is pushed to the plastic shell 1 206 and the plastic shell 2 207 to press the pipeline, the pipeline is clamped to be closed, so that the liquid outlet is closed, the filtering device is composed of a coarse filter layer, a fine filter layer and a support layer, the coarse filter layer is woven with fibers with large pore size, which can effectively intercept blood clots, tissue fragments and other large particle impurities, the fine filter layer is composed of a nano-level microporous membrane, which can accurately filter small impurities and ensure that the stem cells pass smoothly, the support layer is made of high-strength polymer material, which provides structural support for the whole filter screen to prevent deformation under the action of liquid pressure, when infusion is performed, the liquid pushes 407, then 407 presses 409 to make 407 contact with 404, when the liquid flows down, 407 rebounds under the action of 409 to block the upper port to prevent backflow of blood.

[0063] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, and are not intended to limit the present application; although the present application has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions recorded in the above embodiments can be modified, or some or all of the technical features can be replaced by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A three-pronged hematopoietic stem cell infusion set which, after the infusion tube is pretreated with physiological saline in a physiological saline bag (1) and a physiological saline bag (101), transports a hematopoietic stem cell suspension in a hematopoietic stem cell suspension bag (102) into a patient's body through the infusion tube, characterized in that: The physiological saline bag one (1), physiological saline bag two (101) and stem cell suspension bag (102) bottom are equipped with rubber plug (118), a plurality of rubber plug (118) bottom communication branch pipe one (119), branch pipe two (120) and branch pipe three (121), and the surface is equipped with quick closing switch, branch pipe one (119) and branch pipe two (120) communication branch pipe two (120) and branch pipe three (121) communication branch pipe three (121) and branch pipe two (120) communication branch pipe two (120) bottom communication drip pipe, drip pipe bottom through the infusion pipeline communication filter device, filter device bottom through the infusion pipeline communication adjustment device, adjustment device bottom through the infusion pipeline communication anti-backflow device, anti-backflow device through the infusion pipeline and patient vein communication; ​ A plurality of rubber plug (118) surface is equipped with prevent misplug frame one (103) and prevent misplug frame two (104), prevent misplug frame one (103) and prevent misplug frame two (104) inner wall are equipped with through slot (106) and prevent misplug slot (107), a plurality of prevent misplug slot (107) shape is not same, a plurality of prevent misplug frame one (103) inner wall are equipped with sliding groove one (108), sliding groove one (108) inner wall sliding connection prevent misplug baffle (109) and drive sliding block (110), prevent misplug baffle (109) bottom fixed connection block (111), connection block (111) is fixed to drive sliding block (110) top, prevent misplug baffle (109) one side through hole (112) is equipped with, sliding groove one (108) inner wall fixed spring one (113), spring one (113) the other end is fixed to connection block (111) one side, a plurality of prevent misplug frame one (103) bottom are equipped with prevent misplug head (105), a plurality of prevent misplug head (105) shape and its top prevent misplug slot (107) corresponding, prevent misplug head (105) surface through sliding groove two (114) is equipped with, prevent misplug head (105) inner wall is equipped with bottle plug puncture ware (115), bottle plug puncture ware (115) surface fixed push block (116), push block (116) sliding sliding groove two (114) inner wall, a plurality of bottle plug puncture ware (115) bottom communication branch pipe one (119), branch pipe two (120) and branch pipe three (121).

2. A three-pronged hematopoietic stem cell infusor according to claim 1, wherein: The quick closing switch includes a switch body (2), a sliding groove three (201) is arranged in the switch body (2), a control piece (202) is slidably connected to the inner wall of the sliding groove three (201), a pressing cover (203) is fixed to one side of the control piece (202), a push rod (204) is fixed to the other side of the control piece (202), the push rod (204) is slidably arranged in the inner wall of the sliding groove three (201), a pressing block (205) is fixed to one end of the push rod (204), plastic shell one (206) and plastic shell two (207) are arranged on the surfaces of the branch pipe one (119), the branch pipe two (120) and the branch pipe three (121), the plastic shell one (206) and the plastic shell two (207) are fixed with plastic plates (208) on one side, the plastic plates (208) are arranged on one side of the switch body (2), a guide groove one (209), a guide groove two (210), a guide groove three (211) and a guide groove four (212) are arranged on one side of the control piece (202), the inner wall bottom of the guide groove one (209) is higher than the inner wall bottom of the guide groove two (210), the inner wall bottom of the guide groove two (210) is higher than the inner wall bottom of the guide groove three (211), the guide groove three (211) and the guide groove four (212) are upwardly arranged, the inner wall bottom of the guide groove four (212) is higher than the inner wall bottom of the guide groove one (209), a rotating shaft (214) is rotatably connected to the inner wall of the sliding groove three (201), the rotating shaft (214) is fixed with a connecting rod one (215) and a connecting rod two (216), the connecting rod two (216) is fixed with a spring three (217) at the top, the other end of the spring three (217) is fixed to the bottom of the connecting rod one (215), the bottom of the connecting rod one (215) is fixed with a driving shaft (218), and the driving shaft (218) is arranged in the inner wall of the guide groove one (209).

3. A three-pronged hematopoietic stem cell infusor according to claim 1, wherein: The filter device includes a liquid collector (3), the inner wall of the liquid collector (3) is fixed with a partition one (301), one side of the liquid collector (3) is fixed with a filter ring (302), the inner wall of the filter ring (302) is provided with a coarse filter layer (303), one side of the coarse filter layer (303) is provided with a fine filter layer (304), one side of the fine filter layer (304) is provided with a supporting layer (305), one side of the filter ring (302) is fixed with a liquid outlet device (306), and the inner wall of the liquid outlet device (306) is fixed with a partition two (307).

4. The three-pronged hematopoietic stem cell infusor of claim 1, wherein: The backflow prevention device includes a backflow prevention device body (4), a spherical groove (401) is opened in the inner wall of the backflow prevention device body (4), a strip-shaped fixed block (403) is fixed to the inner wall of the spherical groove (401), a supporting rod (402) is fixed to one side of the strip-shaped fixed block (403), a spherical supporting piece (404) is fixed to one side of the supporting rod (402), a sliding groove four (405) is opened in one side of the spherical supporting piece (404), a sliding column one (406) is slidably connected to the inner wall of the sliding groove four (405), a sealing cap (407) is fixed to one side of the sliding column one (406), and a sliding column two (408) is fixed to the other side of the sliding column one (406), a sliding groove five (410) is opened in one end of the supporting rod (402), the sliding column two (408) is slidably connected to the inner wall of the sliding groove five (410), a spring four (409) is fixed to one side of the sliding column two (408), and the other end of the spring four (409) is fixed to the inner wall of the sliding groove four (405).

5. The three-pronged hematopoietic stem cell infusor of claim 1, wherein: The adjusting device includes an adjuster body (5), a component groove (501) is opened in one side of the adjuster body (5), a fixed shaft (502) is fixed to the inner wall of the component groove (501), a rotating piece (503) is rotatably connected to the surface of the fixed shaft (502), a pull adjustment switch (504) is fixed to the surface of the rotating piece (503), an arrow indicating mark (507) is opened in one side of the pull adjustment switch (504), a pressing piece (505) is fixed to the surface of the rotating piece (503), and a size prompt mark (506) is opened in one side of the adjuster body (5).

6. A three-pronged hematopoietic stem cell infusor according to claim 1, wherein: The inner wall of the first anti-misplug frame (103) is rotatably connected with a rotating shaft (601), a rotating circular groove (6) is opened from one side to the other side of the second anti-misplug frame (104), a square groove (604) is opened in the inner wall of the rotating circular groove (6), the rotating shaft (601) is arranged in the inner wall of the rotating circular groove (6), a pull block (602) is fixed to one end of the rotating shaft (601), and a clamping block (603) is fixed to the other end of the rotating shaft (601).

7. A three-pronged hematopoietic stem cell infusor according to claim 6, wherein: A vertical limiting block (701) is arranged on the top of the pull block (602), a horizontal limiting block (702) is arranged on the bottom of the pull block (602), the vertical limiting block (701) is fixed to one side of the first anti-misplug frame (103), and the horizontal limiting block (702) is fixed to one side of the first anti-misplug frame (103).

8. A three-pronged hematopoietic stem cell infusor according to claim 2, wherein: Two clamping pieces one (8) are fixed to one side of the plastic shell one (206), a clamping groove one (802) is fixed to one side of the switch body (2), the clamping piece one (8) is clamped in the inner wall of the clamping groove one (802), two clamping pieces two (801) are fixed to one side of the plastic shell two (207), two clamping grooves two (803) are fixed to one side of the switch body (2), and the clamping piece two (801) is clamped in the inner wall of the clamping groove two (803).

9. The three-pronged hematopoietic stem cell infusor of claim 1, wherein: The anti-misplug groove (107) at the bottom of the physiological saline bag one (1) is circular, the anti-misplug groove (107) at the bottom of the physiological saline bag two (101) is rectangular, and the anti-misplug groove (107) at the bottom of the stem cell suspension bag (102) is trapezoidal. Wherein, w represents the width of the rectangle, h represents the height of the rectangle, r represents the radius of the circle, a represents the upper base of the trapezoid, b represents the lower base of the trapezoid, and ht represents the height of the trapezoid.

10. The three-pronged hematopoietic stem cell infusor of claim 3, wherein: The coarse filter layer (303) is woven with polyester fibers, the pore size of the coarse filter layer (303) is 100-200 mu m, the fine filter layer (304) is made of polycarbonate, the pore size of the fine filter layer (304) is 5-40 mu m, the support layer (305) is made of polypropylene, the pore size of the support layer (305) is 500-1200 mu m, and the thickness of the support layer (305) is 0.5-1.5 mm.

Images