Intraocular lens with tab isolation structure

Abstract

Intraocular lenses are disclosed herein that include an optic portion and at least one tab having a proximal end coupled to the optic portion and a distal end. The tab includes a tab lumen extending through at least a portion of the tab. The tab may include one or more tab spacers disposed within the tab lumen. The one or more tab spacers may be configured to counteract or reduce unexpected shape changes caused by external energy directed to the tab.

Description

[0001] Cross-references to related applications

[0002] This application claims priority to U.S. Patent Application No. 63 / 492,430, filed March 27, 2023 and U.S. Patent Application No. 63 / 492,435, filed March 27, 2023, the contents of which are incorporated herein by reference in their entirety. Technical Field

[0003] This disclosure relates generally to the field of intraocular lenses, and more specifically to adjustable intraocular lenses. Background Technology

[0004] Cataracts are a condition involving the clouding of the normally clear lens of the eye. Cataracts occur due to aging, genetic factors, trauma, inflammation, metabolic disorders, or exposure to radiation. Age-related cataracts are the most common type. During cataract surgery, doctors remove the natural lens matrix from the patient's capsule and replace it with an artificial lens (IOL). Traditional IOLs provide one or more selected focal lengths that allow patients to see at a distance. However, after cataract surgery, because the eye can no longer adjust (or change its optical power) to maintain a clear image or focus on objects as their distance changes, patients with traditional IOLs often require glasses or other corrective eyewear for certain activities.

[0005] Newer IOLs (such as accommodative IOLs) allow the eye to regain at least some of its focusing ability. Accommodative IOLs (AIOLs) use available forces in the eye to change a part of the optical system in order to refocus the eye on distant or near targets. Additionally, adjustments may be necessary post-operatively or after implantation in the subject's eye. In some cases, laser treatment can be used to adjust the implanted IOL.

[0006] However, such post-implantation adjustment procedures may also pose challenges to the overall function of the implanted IOL. Therefore, improved solutions are needed to address these issues. The design of such solutions should also take clinical factors into account. Summary of the Invention

[0007] This document discloses an intraocular lens (IOL) with a loop isolation structure. In some embodiments, an IOL is disclosed comprising an optical element portion and a loop, the optical element portion including an optical element fluid chamber, and the loop having a proximal end and a distal end connected to the optical element portion. The loop may include a loop cavity extending through at least a portion of the loop and in fluid communication with the optical element fluid chamber. The loop may include a plurality of loop isolators disposed within the loop cavity.

[0008] The loop isolator can be configured to restrict any radial movement of the outer radial wall of the loop to between 0 and 10 micrometers in response to a laser beam directed at the loop.

[0009] Loop isolators can be configured to counteract or reduce unintended shape changes caused by lasers directed at the loops.

[0010] In some embodiments, the loop cavity may be surrounded by a radially outer wall, a radially inner wall, a front wall, and a rear wall. A loop spacer may extend from the front wall to the rear wall of the loop.

[0011] In some embodiments, each loop separator may include a side, wherein the side of the loop separator does not physically contact the radial inner wall or the radial outer wall of the loop.

[0012] In some embodiments, the loop spacer may be positioned radially closer to the radial inner wall of the loop than to the radial outer wall. The side of at least one loop spacer closest to the radial inner wall may be separated from the radial inner wall by an inner separation distance. Furthermore, the other side of the loop spacer closest to the radial outer wall may be separated from the radial outer wall by an outer separation distance. The outer separation distance may be between 1.5X and 3X of the inner separation distance.

[0013] In some embodiments, at least one of the loop spacers may be configured as a column having a substantially circular cross-section.

[0014] In some embodiments, at least one of the loop separators may have a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0015] In some embodiments, the loop spacer can be arranged as a curved column within the loop cavity.

[0016] In some embodiments, the loop spacer may be positioned at fixed intervals along at least a segment of the loop cavity.

[0017] In some embodiments, the loop may include three to twenty loop spacers. In other embodiments, the loop may include twenty to thirty loop spacers.

[0018] In some embodiments, each loop spacer may include a front end, a rear end, and a spacer segment between the front end and the rear end. The width or diameter of at least one of the front end and the rear end may be greater than the spacer segment between the front end and the rear end.

[0019] In some embodiments, the width or diameter of at least one of the loop separators may remain constant along the length or height of the loop separator.

[0020] In some embodiments, each loop spacer can be measured by its width or diameter and its length or height. The length or height of at least one of the loop spacers can be greater than twice its width or diameter.

[0021] In some embodiments, the loop spacers may be arranged in an arc shape. The loop spacers may include a farthest loop spacer and a nearest loop spacer serving as the endpoints of the arc. The arc formed by the loop spacers can be measured by a central angle or an arc angle. The central angle or arc angle may be between 70 degrees and 74 degrees.

[0022] In some embodiments, the loop may include at least one of an inner cavity filler and an inner cavity expander made of a composite material. The composite material may be configured to expand in response to receiving a laser beam directed at the inner cavity filler or the inner cavity expander.

[0023] In some embodiments, the loop separator may be made of the same material as one or more walls of the loop and is not made of a composite material.

[0024] Also disclosed is an intraocular lens comprising an optical element portion and a loop having a proximal end and a distal end connected to the optical element portion. The loop may include a loop cavity extending through at least a portion of the loop. A plurality of loop spacers may be disposed in an arcuate form within the loop cavity.

[0025] In some embodiments, the loop isolator can be configured to counteract or reduce unintended shape changes caused by a laser beam directed at the loop. For example, the loop isolator can be configured to limit any radial movement of the outer radial wall of the loop to between 0 and 10 micrometers in response to a laser beam directed at the loop.

[0026] In some embodiments, the loop includes at least one of an inner cavity filler and an inner cavity expander made of a composite material. The composite material may be configured to expand in response to receiving a laser beam directed at the inner cavity filler or the inner cavity expander. The loop separator is not made of a composite material.

[0027] In some embodiments, the loop separator may be made of the same material as one or more walls of the loop and is not made of a composite material.

[0028] In some embodiments, the loop cavity may be surrounded by a radially outer wall, a radially inner wall, a front wall, and a rear wall. A loop spacer may extend from the front wall to the rear wall of the loop.

[0029] In some embodiments, the loop spacer may be positioned radially closer to the radial inner wall of the loop than to the radial outer wall. The side of at least one loop spacer closest to the radial inner wall may be separated from the radial inner wall by an inner separation distance. Furthermore, the other side of the loop spacer closest to the radial outer wall may be separated from the radial outer wall by an outer separation distance. The outer separation distance may be between 1.5X and 3X of the inner separation distance.

[0030] In some embodiments, each loop separator may include a side, wherein the side of the loop separator does not physically contact the radial inner wall or the radial outer wall of the loop.

[0031] In some embodiments, at least one of the loop spacers may be configured as a column having a substantially circular cross-section.

[0032] In some embodiments, at least one of the loop separators may have a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0033] In some embodiments, the loop spacer can be arranged as a curved column within the loop cavity.

[0034] In some embodiments, the loop spacer may be positioned at fixed intervals along at least a segment of the loop cavity.

[0035] In some embodiments, the loop may include three to fourteen loop separators.

[0036] In some embodiments, each loop spacer may include a front end, a rear end, and a spacer segment between the front end and the rear end. The width or diameter of at least one of the front end and the rear end may be greater than the spacer segment between the front end and the rear end.

[0037] In some embodiments, the width or diameter of at least one of the loop separators may remain constant along the length or height of the loop separator.

[0038] In some embodiments, each loop spacer can be measured by its width or diameter and its length or height. The length or height of at least one of the loop spacers can be greater than twice its width or diameter.

[0039] In some embodiments, the loop spacers may be arranged in an arc shape. The loop spacers may include a farthest loop spacer and a nearest loop spacer serving as the endpoints of the arc. The arc formed by the loop spacers can be measured by a central angle or an arc angle. The central angle or arc angle may be between 70 degrees and 74 degrees.

[0040] Also disclosed is an intraocular lens comprising: an optical element portion and a loop having a proximal end and a distal end connected to the optical element portion. The loop may include a loop cavity extending through at least a portion of the loop. The loop may include one or more spacers disposed within the loop cavity. At least one of the one or more spacers may have a non-circular cross-section.

[0041] In some embodiments, one or more isolation blocks may be configured to counteract or reduce unintended shape changes caused by a laser pointing at the loop. For example, one or more isolation blocks may be configured to limit any radial movement of the outer radial wall of the loop to between 0 and 10 micrometers in response to a laser pointing at the loop.

[0042] In some embodiments, the loop may include at least one of an inner cavity filler and an inner cavity expander made of a composite material. The composite material may be configured to expand in response to receiving a laser beam directed at the inner cavity filler or the inner cavity expander.

[0043] In some embodiments, one or more isolation blocks may be made of the same material as one or more walls of the loop and are not made of composite materials.

[0044] In some embodiments, the loop cavity may be surrounded by a radially outer wall, a radially inner wall, a front wall, and a rear wall. One or more spacers may extend from the front wall to the rear wall of the loop.

[0045] In some embodiments, each of one or more isolation blocks includes a side, and the side of one or more isolation blocks does not physically contact the radial inner wall or the radial outer wall of the loop.

[0046] In some embodiments, one or more isolation blocks may be positioned radially closer to the radial inner wall of the loop than to the radial outer wall of the loop.

[0047] In some embodiments, the side of at least one of the spacers closest to the radial inner wall of the loop may be separated from the radial inner wall of the loop by an inner separation distance. The other side of the spacer closest to the radial outer wall of the loop may be separated from the radial outer wall of the loop by an outer separation distance. The outer separation distance may be between 1.5X and 3X of the inner separation distance.

[0048] In some embodiments, at least one of the isolation blocks may have a substantially oval cross-section.

[0049] In some embodiments, at least one of the isolation blocks may have a substantially rectangular cross-section.

[0050] In some embodiments, at least one of the isolation blocks may have a substantially elliptical cross-section.

[0051] In some embodiments, the loop may include a plurality of spacers disposed within the loop cavity. The spacers may be positioned at fixed intervals along at least a segment of the loop cavity. Attached Figure Description

[0052] Figure 1A A top plan view of one embodiment of an IOL including loops with loop separators is shown.

[0053] Figure 1B and Figure 1C It shows the section cut along section AA Figure 1A A cross-sectional view of the IOL.

[0054] Figure 2A This shows a portion of the loop of an IOL without a loop separator.

[0055] Figure 2B It is a diagram showing the movement of the radial outer wall of a loop without a loop separator and the movement of the radial outer wall of a loop with a loop separator.

[0056] Figure 3 A cross-sectional view of the loop, including the loop separator, is shown.

[0057] Figure 4A A perspective view of one embodiment of a loop including a loop separator is shown, wherein the front portion of the loop is removed for observation.

[0058] Figure 4B A top plan view showing another embodiment of the loop including the loop separator is shown.

[0059] Figure 5A A perspective view of the loop including the loop separator is shown.

[0060] Figure 5B Showing Figure 5A The loop, wherein the distal end of the loop is removed to show a cross-section of a portion of the loop.

[0061] Figure 6 It is a computed tomography (CT) scan image of a portion of the loop including the loop separator, in which the radial outer wall of the loop is digitally removed.

[0062] Figure 7A A perspective view of another embodiment of a loop including different types of loop separators is shown, wherein the front portion of the loop is removed for observation.

[0063] Figure 7B A perspective view of yet another embodiment of a loop including another type of loop separator is shown, wherein the front portion of the loop is removed for observation. Detailed Implementation

[0064] Figure 1A A top plan view of one embodiment of an IOL 100 including a loop 104 with a loop separator 105 is shown. In some embodiments, the IOL 100 may be an adjustable IOL, such as an accommodative IOL (AIOL). The IOL 100 may be implanted in a subject to correct defocus aberrations, corneal astigmatism, spherical aberrations, or a combination thereof.

[0065] IOL 100 may include an optical element portion 102 and one or more loops 104, including a first loop 104A and a second loop 104B connected to and extending peripherally from the optical element portion 102. IOL 100 may be positioned within the native capsule after the native lens has been removed.

[0066] When implanted within the native capsule, the optical portion 102 can be adapted to refract light entering the eye onto the retina. One or more loops 104 can be configured to engage the capsule and adapted to deform in response to ciliary muscle movements (e.g., muscle relaxation, muscle contraction, or a combination thereof) associated with changes in the shape of the capsule.

[0067] Each loop 104 may include a loop cavity 106 extending through at least a portion of the loop 104. For example, a first loop 104A may include a first loop cavity 106A extending through at least a portion of the first loop 104A, and a second loop 104B may include a second loop cavity 106B extending through at least a portion of the second loop 104B. The loop cavity 106 (e.g., either the first loop cavity 106A or the second loop cavity 106B) may be in fluid communication with or fluidly connected to the optical fluid chamber 108 within the optical component portion 102.

[0068] The optical component fluid chamber 108 can be in fluid communication with one or more loop cavities 106 via one or more fluid channels 110. The fluid channel 110 can be a conduit or passageway that fluidly connects the optical component fluid chamber 108 to the loop cavity 106. The fluid channels 110 can be spaced apart from each other. For example, a pair of fluid channels 110 can be spaced between about 0.1 mm and about 1.0 mm apart. In some embodiments, each fluid channel 110 can have a diameter between about 0.4 mm and about 0.6 mm.

[0069] The loop 104 can be connected to the optical component portion 102 at the reinforcing portion 112. The reinforcing portion 112 can serve as a loop-optical component interface. A pair of fluid channels 110 can be defined or formed within a portion of the reinforcing portion 112.

[0070] like Figure 1AAs shown, the optical component fluid chamber 108 can be in fluid communication with the inner cavity 106A of the first loop through the first pair of fluid channels 110A. The optical component fluid chamber 108 can also be in fluid communication with the inner cavity 106B of the second loop through the second pair of fluid channels 110B.

[0071] In some embodiments, a first pair of fluid channels 110A and a second pair of fluid channels 110B may be positioned substantially on opposite sides of the optical component portion 102. The first pair of fluid channels 110A may be positioned substantially diametrically opposed to the second pair of fluid channels 110B. The first pair of fluid channels 110A and the second pair of fluid channels 110B may be defined or extended through a portion of the optical component portion 102. The first pair of fluid channels 110A and the second pair of fluid channels 110B may be defined or extended through the rear element 132 of the optical component portion 102 (see, for example...). Figure 1B and Figure 1C ).

[0072] Figure 1A It is also shown that each loop 104 (e.g., either a first loop 104A or a second loop 104B) can have a proximal attachment end 114 and a distal free end 116. A loop fluid port 502 may be defined at the proximal attachment end 114 of the loop 104 (see, for example...). Figure 5A and 5B The loop fluid port 502 can serve as an opening for the loop cavity 106. When the loop 104 is coupled to the optical component portion 102, fluid within the loop cavity 106 can flow out of the loop cavity 106 through the loop fluid port 502 and into the optical component fluid chamber 108 via the fluid channel 110. Similarly, fluid within the optical component fluid chamber 108 can flow out of the optical component fluid chamber 108 through a pair of fluid channels 110 and into the loop cavity 106 via the loop fluid port 502.

[0073] Each loop 104 may include a radially outer wall 118 and a radially inner wall 120. The radially outer wall 118 may be configured to face and contact the inner surface of the patient's pocket when the IOL 100 is implanted within the pocket. The radially inner wall 120 may be configured to face the outer peripheral surface 122 of the optic portion 102.

[0074] After the native lens has been removed from the capsular bag, an IOL 100 can be implanted or introduced into the patient's capsular bag. The patient's capsular bag is connected to suspensory ligament fibers, which in turn connect to the patient's ciliary muscle. The capsular bag is elastic, and ciliary muscle movement can change its shape via the suspensory ligament fibers. For example, when the ciliary muscle relaxes, the suspensory ligaments are stretched. This stretching pulls the capsular bag in a generally radially outward direction due to radially outward forces. This pulling on the capsular bag causes it to elongate, creating space within it. When the patient's native lens is present in the capsular bag, it typically becomes flatter (in the anteroposterior direction), which reduces the lens's power, thus allowing for distance vision. In this configuration, the patient's native lens is said to be in a state of disaccommodation or undergoing disaccommodation.

[0075] However, when the ciliary muscle contracts, as occurs when the eye attempts to focus on a near object, the radially inward portion of the muscle moves radially inward, causing the suspensory ligaments to relax. This relaxation allows the elastic capsule to contract and exert a radially inward force on the lens within the capsule. When the patient's native lens is present within the capsule, it typically becomes more curved (e.g., the anterior portion of the lens becomes more curved), giving the lens greater optical power, thus allowing the eye to focus on near objects. In this configuration, the patient's native lens is said to be in a state of accommodation or undergoing accommodation.

[0076] When the IOL 100 is implanted into the patient's capsule, the radial outer wall 118 of the loop 104 can directly engage with or physically contact the portion of the capsule that connects to the suspensory ligament or suspensory ligament fibers. Therefore, the radial outer wall 118 can be configured to respond to capsule-changing forces that are radially applied when the suspensory ligament relaxes and stretches due to ciliary muscle movement.

[0077] When the ciliary muscle contracts, the peripheral region of the elastic capsule changes shape and exerts a radially inward force on the radially outer wall 118 of each loop 104. The radially outer wall 118 can then deform or otherwise change shape, and this deformation or shape change can cause a reduction in the volume of the loop cavity 106. As the volume of the loop cavity 106 decreases, fluid within the loop cavity 106 is moved into or pushed into the optical fluid chamber 108.

[0078] The optical component 102 can change shape in response to fluid entering the optical fluid chamber 108 from the loop cavity 106. This can increase the base power or base spherical power of the IOL 100 and allow patients with the IOL 100 implanted in their eyes to focus on near objects. In this state, the IOL 100 can be considered as having undergone accommodation.

[0079] When the ciliary muscle relaxes, the peripheral region of the elastic capsule stretches radially outward and the capsule elongates. The radial outer wall 118 of the loop 104 can be configured to respond to this change in capsule shape by returning to its undeformed or unstressed configuration. This causes the volume of the loop cavity 106 to increase or return to its undeformed volume. This increase in the volume of the loop cavity 106 can cause fluid within the optical fluid chamber 108 to be drawn out or flow out and back into the loop cavity 106. As previously discussed, fluid moves from the optical fluid chamber 108 into the loop cavity 106 through the same fluid channel 110 formed within the optical portion 102.

[0080] As previously discussed, the optical component 102 can change shape in response to fluid exiting from the optical component fluid chamber 108 and entering the loop cavity 106. This can reduce the fundamental power or fundamental spherical power of the IOL 100 and allow patients with the IOL 100 implanted in their eyes to focus on distant objects or provide distance vision. In this state, the IOL 100 can be considered to have lost accommodation.

[0081] In some embodiments, the IOL 100 may be designed such that the gap 124 or void spatially separates the radially inner wall 120 of the loop 104 from the outer peripheral surface 122 of the optical portion 102. This allows the portions of the loop 104 to change shape or expand in response to external energy directed at the loop 104 (e.g., laser energy).

[0082] Figure 1A It was also shown that one or more portions of each loop 104 could be made of a composite material. As will be discussed in more detail in later sections, the composite material may include an energy-absorbing component, multiple expandable parts, and a crosslinked copolymer for making the remainder of the loop 104, or be made in part from the above. The portions of the loop 104 made of composite material can be configured to respond to a laser 125 directed at the composite material (see, for example...). Figure 1B-1C The shape may be altered (e.g., expanded). Depending on where the composite material is positioned or integrated within each loop 104, the composite material may act as an inner cavity filler 126 to occupy space within the loop inner cavity 106 and / or the inner cavity expander 128 to create more space within the loop inner cavity 106.

[0083] As will be discussed in more detail later, when laser 125 is applied to the composite material configured as cavity filler 126, the composite material can expand, and in this case, the expansion of the composite material can reduce the volume of the loop cavity 106 and displace the fluid within the loop cavity 106 into the optical fluid chamber 108. This can cause the optical portion 102 to change shape (e.g., make the front or rear element of the optical portion 102 more curved), thereby increasing the fundamental power of the optical portion 102.

[0084] Alternatively, when laser 125 is applied to the composite material configured as the cavity expander 128, the composite material can expand, and in this case, the expansion of the composite material can increase the volume of the loop cavity 106 and draw fluid from the optical fluid chamber 108 into the loop cavity 106. This can also change the shape of the optical portion 102 (e.g., making the front or rear element of the optical portion 102 less curved or flatter), thereby reducing the fundamental focal power of the optical portion 102.

[0085] As will be discussed in more detail in a later section, each loop 104 may include a plurality of loop separators 105 that can counteract or reduce the effects of unintended shape changes or deformations caused by the application of laser 125 to the loop 104.

[0086] Although AIOL is depicted and described in this disclosure, any reference to AIOL may also refer to one of the AIOLs discussed and depicted in the following U.S. publications: U.S. Patent Publication No. 2021 / 0100652; U.S. Patent Publication No. 2021 / 0100650; U.S. Patent Publication No. 2020 / 0337833; and U.S. Patent Publication No. 2018 / 0153682; and the following granted U.S. patents: U.S. Patent No. 11,426,270; U.S. Patent No. 10,433,949; U.S. Patent No. 10,299,913; U.S. Patent No. 10,195,020; and U.S. Patent No. 8,968,396, the contents of which are incorporated herein by reference in their entirety.

[0087] Figure 1B and Figure 1C Showing Figure 1A A cross-sectional view taken along section AA of IOL 100. (See attached image.) Figure 1B and Figure 1C As shown, the optical component 102 may include a front element 130 and a rear element 132. An optical component fluid chamber 108 filled with fluid may be defined between the front element 130 and the rear element 132.

[0088] The front element 130 may include a front optical surface 134 and a front inner surface 136 opposite to the front optical surface 134. The rear element 132 may include a rear optical surface 138 and a rear inner surface 140 opposite to the rear optical surface 138. Any one or a combination of the front optical surface 134, the rear optical surface 138, or other similar surfaces may be considered and referred to as external optical surfaces. The front inner surface 136 and the rear inner surface 140 may face the optical fluid chamber 108. At least a portion of the front inner surface 136 and at least a portion of the rear inner surface 140 may serve as chamber walls of the optical fluid chamber 108.

[0089] like Figure 1B and Figure 1C As shown, the optical component 102 may have a lens optical axis 142 extending through the center of the optical component 102 in the front-to-back direction. The lens optical axis 142 may extend through the center of both the anterior element 130 and the rear element 132.

[0090] The thickness of the anterior element 130 may be greater at or near the lens optical axis 142 than at the periphery of the anterior element 130. In some embodiments, the thickness of the anterior element 130 may gradually increase from the periphery of the anterior element 130 toward the lens optical axis 142.

[0091] In some embodiments, the thickness of the anterior element 130 at or near the lens optical axis 142 may be between about 0.45 mm and about 0.55 mm. In these and other embodiments, the thickness of the anterior element 130 in the peripheral area may be between about 0.20 mm and about 0.40 mm. Furthermore, the anterior inner surface 136 of the anterior element 130 may have a smaller curvature or be flatter than the anterior optical surface 134.

[0092] The thickness of the posterior element 132 may be greater at or near the lens optical axis 142 than the portion of the posterior element 132 radially outward from the lens optical axis 142 but before reaching the protruding periphery 144 of the posterior element 132. The thickness of the posterior element 132 may gradually decrease from the lens optical axis 142 to the portion radially outward from the lens optical axis 142 (but before reaching the protruding periphery 144). Figure 1B and Figure 1C As shown, the thickness of the rear element 132 can increase again from the radially inner portion of the protrusion periphery 144 to the radially outer portion of the protrusion periphery 144.

[0093] In some embodiments, the thickness of the rear element 132 at or near the lens optical axis 142 may be between about 0.45 mm and about 0.55 mm. In these and other embodiments, the thickness of the rear element 132 radially outward from the lens optical axis 142 (but before reaching the protrusion periphery 144) may be between about 0.20 mm and about 0.40 mm. The thickness of the rear element 132 near the radially outer portion of the protrusion periphery 144 may be between about 1.00 mm and 1.15 mm. Furthermore, the rear inner surface 140 of the rear element 132 may have a smaller curvature or be flatter than the rear optical surface 138.

[0094] The optical component 102 may have a base focal length or a base spherical focal length. The base focal length of the optical component 102 may be configured to change based on the internal fluid pressure within the fluid-filled optical component fluid chamber 108. The base focal length of the optical component 102 may be configured to increase or decrease as fluid enters or leaves the fluid-filled optical component fluid chamber 108.

[0095] The base focal length of the optical component 102 can be configured to adjust according to the fluid flow. Figure 1B The curvature of the optical fluid chamber 108, which is filled with fluid and depicted by a curved dashed arrow, increases as fluid enters from the inner cavity 106 of the loop. For example, the front element 130 of the optical component 102 may be configured to increase its curvature in response to fluid entering the optical fluid chamber 108. Additionally, for example, the rear element 132 of the optical component 102 may be configured to increase its curvature in response to fluid entering the optical fluid chamber 108. In another embodiment, both the front element 130 and the rear element 132 may be configured to increase their curvature in response to fluid entering the optical fluid chamber 108.

[0096] The base focal length of the optical component 102 can be configured to adjust according to the fluid flow. Figure 1C The curved dashed arrows depict the decrease in curvature as fluid leaves or is drawn out of the fluid-filled optical chamber 108 and enters the loop fluid cavity 106. For example, the front element 130 of the optical portion 102 may be configured to reduce its curvature (or flatten) in response to fluid leaving the optical chamber 108. Additionally, for example, the rear element 132 of the optical portion 102 may be configured to reduce its curvature (or flatten) in response to fluid leaving the optical chamber 108. In another embodiment, both the front element 130 and the rear element 132 may be configured to reduce their curvature in response to fluid leaving the optical chamber 108.

[0097] It should be noted that, although Figure 1B and Figure 1CThe curved dashed arrows illustrate the entry and exit of fluid from the loop cavity 106 into the optical fluid chamber 108, but the fluid also enters and exits the optical fluid chamber 108 via fluid channels 110 and orifices 146 defined along the rear element 132. The orifice 146 can be a hole or opening defined along the rear element 132, serving as the end of the fluid channel 110. When the IOL 100 includes a pair of fluid channels 110, the pair of orifices 146 serving as the ends of the fluid channels 110 can be spaced apart from each other between approximately 0.1 mm and approximately 1.0 mm.

[0098] like Figure 1B and Figure 1C As shown, one or more portions of IOL 100 may be made of a composite material designed to respond to external energy (such as laser 125) applied to the composite material. For example, one or more portions of each loop 104 of IOL 100 may be made of a composite material.

[0099] In some embodiments, laser 125 may be a green laser with a wavelength between about 480 nm and 650 nm (e.g., 532 nm). In these embodiments, the laser that generates laser 125 may be neodymium-doped yttrium aluminum garnet (Nd:YAG).

[0100] In other embodiments, the laser 125 may have a wavelength between 1030 nm and 1035 nm. In these embodiments, the laser that generates the laser 125 may be a femtosecond laser.

[0101] Depending on the location of the composite material or its integration within each loop 104 and the composition of the composite material, the composite material can serve as an inner cavity filler 126 or an inner cavity expander 128.

[0102] For example, the lumen filler 126 may be part of a loop 104 made of a composite material, designed to reduce the volume of the loop lumen 106 in response to external energy (e.g., laser 125) directed at the lumen filler 126. The lumen expander 128 may be part of a loop 104 made of a composite material, designed to increase the volume of the loop lumen 106 in response to external energy (e.g., laser 125) directed at the lumen expander 128.

[0103] like Figure 1B and Figure 1C As shown, each loop 104 may include a channel 148. The channel 148 may be defined within a portion of the radial inner wall 120 of the loop. For example, the channel 148 may extend partially into the radial inner wall 120 of the loop. The channel 148 may be in fluid communication with the loop cavity 106 or may be considered part of the loop cavity 106.

[0104] In some embodiments, the lumen filler 126 may be positioned at the rear of the channel 148. In these embodiments, the lumen filler 126 may replace or serve as the rear portion of the radial inner wall 120 of the loop. The lumen filler 126 may also be positioned radially inward within the portion of the loop lumen 106 that is not part of the channel 148.

[0105] At least a portion of the lumen filler 126 may be in fluid communication with the channel 148. For example, at least a portion of the front portion or layer of the lumen filler 126 may be in fluid communication with the channel 148 or otherwise exposed to the channel.

[0106] like Figure 1B and Figure 1C As shown, in some embodiments, the radially outer side of the lumen filler 126 is not in fluid communication with the loop lumen 106. In these embodiments, the radially outer side of the lumen filler 126 is separated from the loop lumen 106 by a portion of the loop 104 that is not made of composite material.

[0107] The lumen expander 128 can be positioned radially inside the channel 148. The lumen expander 128 can also be positioned in front of the lumen filler 126. More specifically, for example, the lumen expander 128 can be positioned in front of the radially inner portion of the lumen filler 126.

[0108] In some embodiments, the lumen expansion 128 may be positioned within the channel 148. In these embodiments, the lumen expansion 128 may be positioned at the radially innermost end of the channel 148. For example, the shape of the loop radially inner wall 120 may be tapered when the loop radially inner wall 120 is closer to the optical component portion 102. The lumen expansion 128 may be positioned at the radially innermost end of the channel 148, near the tapered end of the loop radially inner wall 120.

[0109] like Figure 1B and Figure 1C As shown, the radially outer side of the lumen expansion 128 may be in fluid communication with the channel 148 and the loop lumen 106. In some embodiments, the lumen expansion 128 does not extend all the way to the radially innermost portion of the loop radial inner wall 120. In these embodiments, a portion of the loop 104 that is not made of composite material may serve as the radially innermost portion of the loop radial inner wall 120 and separate the lumen expansion 128 from the outer peripheral surface 122 of the optical component portion 102.

[0110] In some embodiments, the lumen expander 128 may be connected or otherwise coupled to the lumen filler 126. In these and other embodiments, the lumen expander 128 and the lumen filler 126 may be or refer to different portions of the same composite material. For example, the lumen filler 126 may be substantially shaped as a curved corner, and the lumen expander 128 may be substantially shaped as a rectangular cuboid extending from the front surface of the corner.

[0111] Those skilled in the art will understand that even when different shades are used in the drawings to distinguish between the inner cavity filler 126 and the inner cavity expander 128 (i.e., a darker shaded pattern is used to depict the inner cavity expander 128 and a lighter shaded pattern is used to depict the inner cavity filler 126), both the inner cavity filler 126 and the inner cavity expander 128 may be made of the same composite material or refer to different parts / features of the same composite material.

[0112] In other embodiments, the lumen filler 126 and the lumen expander 128 may be made of different types of composite materials. In these embodiments, the lumen filler 126 may be made of a first type of composite material, and the lumen expander 128 may be made of a second type of composite material. In some embodiments, the lumen filler 126 and the lumen expander 128 may be made of composite materials of different colors. For example, the composite material may contain energy-absorbing components, such as energy-absorbing pigments or dyes.

[0113] As a more specific example, the cavity filler 126 or the cavity expander 128 may be made of a composite material containing a black energy-absorbing pigment (such as graphitized carbon black). In this example, if one of the cavity filler 126 or the cavity expander 128 is made of a composite material containing graphitized carbon black, the other may be made of a different type of composite material containing a red energy-absorbing pigment such as an azo dye (e.g., Disperse Red 1 dye).

[0114] like Figure 1BAs shown, external energy (such as laser 125) can be directed at the cavity filler 126 to cause at least a portion of the cavity filler 126 to expand and increase in size. For example, this expansion can itself manifest as a protrusion growing or protruding from the cavity filler 126. For instance, when laser 125 is directed at the front portion or layer of the cavity filler 126 that is in fluid communication with or otherwise exposed to the channel 148, a protrusion can grow from the front portion and into the channel 148. Since the channel 148 is in fluid communication with (or is considered part of) the loop cavity 106, the volume of the loop cavity 106 can decrease in response to the formation of the protrusion. This can allow fluid within the loop cavity 106 to be pushed into or otherwise displaced into the optical fluid chamber 108. As a result, at least one of the front element 130 and the rear element 132 can increase its curvature, and the base focal length of the optical portion 102 can increase in response to laser stimulation directed at the cavity filler 126.

[0115] External energy, such as laser 125 (e.g., a laser pulse), can be directed at the cavity expander 128 to cause at least a portion of the cavity expander 128 to expand and increase in size. This expansion can itself manifest as an expansion of the channel 148, as will be discussed in more detail later. For example, when laser 125 is directed at the cavity expander 128, the cavity expander 128 can increase in size and widen the channel 148. Since the channel 148 is in fluid communication with (or is considered part of) the loop cavity 106, the volume of the loop cavity 106 can increase in response to the increase in the cavity expander 128. This allows fluid to be drawn from the optical fluid chamber 108 and into the loop cavity 106. As a result, at least one of the front element 130 and the rear element 132 can have its curvature reduced, and the fundamental focal power of the optical portion 102 can decrease in response to the laser 125 (e.g., a laser pulse) directed at the cavity expander 128.

[0116] As will be discussed in more detail in a later section, each loop 104 may include a plurality of loop separators 105 that can counteract or reduce the effects of unintended shape changes or deformations caused by the application of laser 125 to the loop 104.

[0117] In some embodiments, the fluid within the optical component fluid chamber 108 and the loop cavity 106 may be oil. More specifically, in some embodiments, the fluid within the optical component fluid chamber 108 and the loop cavity 106 may be silicone oil or a fluid. For example, the fluid may be silicone oil partially composed of diphenylsiloxane. In other embodiments, the fluid may be silicone oil partially composed of a ratio of two dimethylsiloxane units to one diphenylsiloxane unit. More specifically, in some embodiments, the fluid may be silicone oil partially composed of diphenyltetramethylcyclotrisiloxane or a copolymer of diphenylsiloxane and dimethylsiloxane. In further embodiments, the fluid may be silicone oil comprising a branched polymer.

[0118] A fluid (e.g., silicone oil) may be refractively matched to the lens body material used to fabricate the optical component portion 102. When the fluid is refractively matched to the lens body material, the entire optical component portion 102 containing the fluid may function as a single lens. For example, the fluid may be selected such that it has a refractive index between about 1.48 and 1.53 (or between about 1.50 and 1.53). In some embodiments, the fluid (e.g., silicone oil) may have a polydispersity index between about 1.2 and 1.3. In other embodiments, the fluid (e.g., silicone oil) may have a polydispersity index between about 1.3 and 1.5. In other embodiments, the fluid (e.g., silicone oil) may have a polydispersity index between about 1.1 and 1.2. Other exemplary fluids are described in U.S. Patent Publication No. 2018 / 0153682, which is incorporated herein by reference in its entirety.

[0119] The optical component portion 102 may be partially made of a deformable or flexible material. In some embodiments, the optical component portion 102 may be partially made of a deformable or flexible polymeric material. For example, the front element 130, the rear element 132, or a combination thereof may be partially made of a deformable or flexible polymeric material. The one or more loops 104 (e.g., the first loop 104A, the second loop 104B, or a combination thereof) may be partially made of the same deformable or flexible material as the optical component portion 102. In other embodiments, the one or more loops 104 may be partially made of a material different from that of the optical component portion 102.

[0120] In some embodiments, the optical component portion 102 may include or be partially made of a lens body material. The lens body material may be partially made of a crosslinked copolymer comprising copolymer blends. The copolymer blends may include alkyl acrylates or alkyl methacrylates, fluoroalkyl (meth)acrylates, and phenylalkyl acrylates. It is contemplated and understood by those skilled in the art that these types of acrylic crosslinked copolymers are generally copolymers of various acrylates, methacrylates, or combinations thereof, and unless otherwise specified, the term "acrylate" as used herein may be understood to interchangeably refer to acrylates, methacrylates, or combinations thereof. The crosslinked copolymer used to make the lens body material may include about 3% to 20% (by weight) of alkyl acrylates, about 10% to 35% (by weight) of fluoroalkyl acrylates, and about 50% to 80% (by weight) of phenylalkyl acrylates. In some embodiments, the crosslinked copolymer may include, or be partially composed of, each of the following: n-butyl acrylate as an alkyl acrylate, trifluoroethyl methacrylate as a fluoroalkyl acrylate, and ethyl styrene acrylate as a phenylalkyl acrylate. More specifically, the crosslinked copolymer used to make the lens body material may include about 3% to 20% (by weight) (e.g., between about 12% and 16%) of n-butyl acrylate, about 10% to 35% (by weight) (e.g., between about 17% and 21%) of trifluoroethyl methacrylate, and about 50% to 80% (by weight) (e.g., between about 64% and 67%) of ethyl styrene acrylate.

[0121] The final composition of the crosslinked copolymer used to make the lens body material may also include a crosslinker or crosslinking agent, such as ethylene glycol dimethacrylate (EGDMA). For example, the final composition of the crosslinked copolymer used to make the lens body material may also include about 1.0% of a crosslinker or crosslinking agent (e.g., EGDMA). The final composition of the crosslinked copolymer used to make the lens body material may also include an initiator or initiator (e.g., Perkadox 16) and a UV absorber.

[0122] One or more loops 104 may include or be partially made of loop material. The loop material may include or be partially made of crosslinked copolymers, which include copolymer blends. Copolymer blends may include alkyl acrylates, fluoroalkyl acrylates, and phenylalkyl acrylates. For example, the crosslinked copolymer used to make the loop material may include about 10% to 25% (by weight) of alkyl acrylates, about 10% to 35% (by weight) of fluoroalkyl acrylates, and about 50% to 80% (by weight) of phenylalkyl acrylates. In some embodiments, the crosslinked copolymer used to make the loop material may include about 10% to 25% (by weight) (e.g., between about 19% and about 23%) of n-butyl acrylate, about 10% to 35% (by weight) (e.g., between about 14% and about 18%) of trifluoroethyl methacrylate, and about 50% to 80% (by weight) (e.g., between about 58% and about 62%) of styrene acrylate. The final composition of the crosslinked copolymer used to make the loop material may also include about 1.0% of a crosslinker or crosslinking agent, such as EGDMA. The final composition of the crosslinked copolymer used to make the loop material may also include several photoinitiators or photoinitiators (e.g., camphorquinone, 1-phenyl-1,2-propanedione and 2-ethylhexyl-4-(dimethylamino)benzoate).

[0123] In some embodiments, the refractive index of the lens body material may be between about 1.48 and about 1.53. In some embodiments, the refractive index of the lens body material may be between about 1.50 and about 1.53 (e.g., about 1.5178).

[0124] The front element 130 may be attached to or otherwise adhered to the rear element 132 via adhesive 150 or an adhesive layer. The adhesive layer may be substantially annular. The adhesive 150 or adhesive layer may be positioned at the peripheral edge of the optical component portion 102, between the front element 130 and the rear element 132. For example, the adhesive 150 may be positioned on top of the raised periphery 144 of the rear element 132.

[0125] Adhesive 150 or the adhesive layer may include or be made in part of a biocompatible adhesive. Adhesive 150 or the adhesive layer may include or be made in part of a biocompatible polymer adhesive.

[0126] Adhesive 150 or the adhesive layer may include or be partially made of a crosslinkable polymer precursor formulation. The crosslinkable polymer precursor formulation may include or be partially made of: copolymer blends, hydroxy-functional acrylic monomers, and photoinitiators.

[0127] The copolymer blend may include alkyl acrylates (e.g., about 41% to about 45% by weight of n-butyl acrylate), fluoroalkyl acrylates (e.g., about 20% to about 24% by weight of trifluoroethyl methacrylate), and phenylalkyl acrylates (about 28% to about 32% by weight of styrene acrylate). The hydroxyl-functionalized acrylic monomer may be 2-hydroxyethyl acrylate (HEA). A photoinitiator may be used to promote the curing of the adhesive. For example, the photoinitiator may be Darocur 4265 (a 50 / 50 blend of diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide and 2-hydroxy-2-methylphenylacetone).

[0128] In some embodiments, the same adhesive 150 used to bond the front element 130 to the rear element 132 may also be used to bond or attach one or more loops 104 to the optical portion 102.

[0129] In some embodiments, the composite material may include a composite substrate, an energy-absorbing component, and multiple expandable components. As previously discussed, one or more portions of each loop 104 may be made of the composite material.

[0130] The composite substrate can be composed of hydrophobic acrylic materials. For example, the composite substrate can be composed of styrene acrylate (PEA), styrene methacrylate (PEMA), or a combination thereof.

[0131] In one example embodiment, the composite substrate may include a methacrylate-functionalized or methacrylate-functionalized crosslinkable polymer and a reactive acrylic monomer diluent, which includes lauryl methacrylate (dodecyl methacrylate or SR313) and ADMA. By controlling the amount of lauryl methacrylate (SR313) relative to ADMA, the overall corresponding hardness (i.e., more ADMA) or softness (i.e., more SR313) of the cured composite material can be controlled. The methacrylate-functionalized or methacrylate-functionalized crosslinkable polymer can be prepared using a crosslinkable polymer precursor formulation.

[0132] Crosslinkable polymer precursor formulations may include the same copolymer blends used for making optical parts and loops. The copolymer blends may include alkyl acrylates or alkyl methacrylates (e.g., n-butyl acrylate), fluoroalkyl (meth)acrylates (e.g., trifluoroethyl methacrylate), and phenylalkyl acrylates (e.g., ethyl phenyl acrylate). For example, the copolymer blend may include about 41% to about 45% (by weight) of n-butyl acrylate, about 20% to about 24% (by weight) of trifluoroethyl methacrylate, and about 28% to about 32% (by weight) of ethyl phenyl acrylate. Crosslinkable polymer precursor formulations may include copolymer blends, hydroxy-functionalized acrylic monomers (e.g., HEA), and photoinitiators (e.g., Darocur 4265 or a 50 / 50 blend of diphenyl(2,4,6-trimethylbenzoyl)-phosphine oxide and 2-hydroxy-2-methylphenylacetone) or partially thereof.

[0133] The composite substrate may include about 50% to about 65% (e.g., about 55% to about 60%) (by weight) of methacrylate functional groups or methacrylate functional group crosslinkable polymers (as discussed above), about 32% to about 38% (e.g., about 32.70%) (by weight) of reactive acrylic monomer diluent lauryl methacrylate (SR313), and about 5% to about 9% (e.g., about 7.30%) (by weight) of reactive acrylic monomer diluent adamantyl methacrylate (ADMA).

[0134] The composite material can be produced in several operations. A first operation may include preparing an uncolored composite substrate. A second operation may include mixing the composite substrate with an energy-absorbing component, an expandable component, and an initiator such as one or more photoinitiators, thermal initiators, or combinations thereof. A third operation may include placing the uncured composite material into a desired location within loop 104 (e.g., near channel 148) and curing the composite material into place.

[0135] For example, uncolored composite substrates can be mixed with energy-absorbing components such as dyes (e.g., Disperse Red 1 dye) or pigments (graphitized carbon black). Energy-absorbing components will be discussed in more detail below.

[0136] In some embodiments, the expandable component may comprise about 5.0% to about 15.0% by weight of the final composite formulation. More specifically, the expandable component may comprise about 8.0% to about 12.0% (e.g., about 10.0%) by weight of the final composite formulation. In these and other embodiments, the energy-absorbing component may comprise about 0.044% to about 0.44% (or about 0.55%) by weight of the final composite formulation.

[0137] The photoinitiator may be Omnirad 2022 (bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide / 2-hydroxy-2-methyl-1-phenyl-1-propanone). The photoinitiator may comprise about 1.30% by weight of the final formulation of the composite material. Additionally, the composite material may also include a thermal initiator. The thermal initiator may comprise about 1.00% by weight of the final formulation of the composite material. In some embodiments, the thermal initiator may be a dialkyl peroxide, such as... Peroxide. In other embodiments, the thermal initiator may be Perkadox.

[0138] In some embodiments, the energy-absorbing component can absorb external energy (e.g., laser energy), convert the energy into heat, and conduct the energy to the composite substrate to cause the composite substrate to expand.

[0139] In some embodiments, the expandable component may be expandable microspheres comprising an expandable thermoplastic shell and a foaming agent contained within the expandable thermoplastic shell. The microspheres may be configured to expand such that the diameter of at least one microsphere may increase by about 2 times the original diameter. In other embodiments, the microspheres may be configured to expand such that the diameter of at least one microsphere may increase by about 4 times or four times the original diameter. In still other embodiments, the microspheres may be configured to expand such that the diameter of at least one microsphere may increase by between about 2 times and about 4 times (or about 3.5 times) the original diameter. For example, the microspheres may initially have a diameter of about 12 μm. In response to external energy applied to or directed at the composite material, or in response to energy transferred or transmitted to the microspheres, the diameter of the microspheres may increase to about 40 μm.

[0140] The volume of at least one of the microspheres can be configured to expand by about ten times (10X) to about 50 times (50X) in response to external energy applied to or directed to the composite material or in response to energy transferred or transmitted to the microspheres.

[0141] In some embodiments, the blowing agent may be an expandable fluid, such as an expandable gas. More specifically, the blowing agent may be a branched hydrocarbon. For example, the blowing agent may be isopentane. In other embodiments, the blowing agent may be or include cyclopentane, pentane, or a mixture of cyclopentane, pentane, and isopentane.

[0142] Each expandable component may include a thermoplastic shell. The thickness of the thermoplastic shell may vary as the size of the expandable component increases. More specifically, the thickness of the thermoplastic shell may decrease as the size of the expandable component increases. For example, when the expandable component is an expandable microsphere, the thickness of the thermoplastic shell (i.e., its thickness in the radial direction) may decrease as the diameter of the expandable microsphere increases.

[0143] In some embodiments, the thermoplastic shell may be made in part from a nitrile or an acrylonitrile copolymer. For example, the thermoplastic shell may be made in part from acrylonitrile, styrene, butadiene, methyl acrylate, or a combination thereof.

[0144] As previously discussed, expandable components can comprise between approximately 8.0% and approximately 12% by weight of the final composite formulation. Expandable components can comprise approximately 10% by weight of the final composite formulation.

[0145] Expandable components may be dispersed or otherwise distributed within a composite matrix that constitutes the bulk of the composite material. The composite matrix may serve as a matrix for holding or supporting the expandable components. The composite material may expand in response to the expansion of the expandable components (e.g., thermoplastic microspheres). For example, the volume of the composite material may increase in response to the expansion of the expandable components.

[0146] The composite material also includes an energy-absorbing component. In some embodiments, the energy-absorbing component may be an energy-absorbing colorant.

[0147] In some embodiments, the energy-absorbing colorant may be an energy-absorbing dye. For example, the energy-absorbing dye may be an azo dye. In some embodiments, the azo dye may be a red azo dye, such as Disperse Red 1. In other embodiments, the azo dye may be an orange azo dye, such as Disperse Orange (e.g., Disperse Orange 1); a yellow azo dye, such as Disperse Yellow (e.g., Disperse Yellow 1); a blue azo dye, such as Disperse Blue (e.g., Disperse Blue 1); or a combination thereof.

[0148] In an additional embodiment, the energy-absorbing colorant may be or may include a pigment. For example, the energy-absorbing colorant may be or may include graphitized carbon black as a pigment.

[0149] Similar to expandable components, energy-absorbing components can be dispersed or otherwise distributed within the composite substrate that constitutes the main body of the composite material. The composite substrate can serve as a matrix for retaining or supporting both the expandable components and the energy-absorbing components.

[0150] As previously discussed, the energy-absorbing component may comprise between about 0.025% and about 1.0% (or more specifically, about 0.045% and about 0.45%) by weight of the final formulation of the composite material.

[0151] Energy-absorbing components (e.g., azo dyes, graphitized carbon black, or combinations thereof) can absorb or capture external energy (e.g., light energy or, more specifically, laser energy) applied to or directed at the composite material. The energy-absorbing components can absorb or capture external energy and then convert or transfer the energy into heat or heat to the expandable component.

[0152] When heat is transferred or transported to the expandable component, the thermoplastic shell can soften and begin to flow. The thermoplastic shell of the expandable component can then begin to thin or decrease in thickness in response to the heat transferred or transported to it. As the thermoplastic shell begins to soften and decrease in thickness, the foaming agent within the expandable component can expand. The foaming agent can also expand in response to the heat transferred or transported to the expandable component. This expansion of the foaming agent can cause the expandable component (e.g., thermoplastic microspheres) to expand or increase in volume. This ultimately causes the composite material to expand or increase in volume.

[0153] As previously discussed, the external energy can be laser 125, and the energy-absorbing component can absorb or capture the laser 125 directed at the composite material, converting or transferring the light energy into heat energy or heating the expandable component. The foaming agent within the expandable component can expand or be excited in response to the heat energy or heat. The expandable component, and the final composite material, can expand or increase in volume in response to this light energy directed at the composite material.

[0154] Figure 2A A portion of the loop 200 of the IOL without a loop separator is shown. Figure 2A The IOL shown, including loop 200, can be similar to Figure 1A-1C The IOL 100 depicted differs in that it does not have any loop separators 105 in the loop cavity 202 that supports the loop 200.

[0155] The loop 200 may include a front wall 204, a rear wall 206, a radially outer wall 208, and a radially inner wall 210 surrounding the loop cavity 202. The cavity passage 212 may extend radially into the radially inner wall 210. Furthermore, the loop 200 may include a cavity filler 214, a cavity expander 216, or a combination thereof. The cavity filler 214 and the cavity expander 216 may be made of composite materials and may function similarly to the cavity filler 126 and the cavity expander 128, respectively.

[0156] Figure 2A The aftereffects are demonstrated when laser 125 (e.g., a laser pulse from a 532 nm laser) is directed at cavity filler 214, cavity expander 216, or a combination thereof. For example, laser 125 may be directed at... Figure 2A One or more target sites 218 are shown.

[0157] like Figure 2AAs shown, the composite material constituting the cavity filler 214 and the cavity expander 216 can expand in response to the application of laser energy. This expansion of the composite material may also unintentionally cause other parts of the loop 200 to change shape, expand, or bend. For example, this expansion of the composite material may unintentionally affect the size of the loop cavity 202. Furthermore, this expansion of the composite material may also cause unintentional loop bending and asymmetric bending of the optical components of the IOL.

[0158] The outline of loop 200, shown in dashed lines, illustrates the front wall 204, rear wall 206, and radial inner wall 210 of the loop before laser energy is applied. Figure 2A As can be seen, after the laser 125 is directed or otherwise delivered to the cavity filler 214, the cavity expander 216, or a combination thereof, the anterior loop wall 204 may expand in a forward direction and the posterior loop wall 206 may expand in a rearward direction. In some cases, this expansion of the anterior loop wall 204 and the posterior loop wall 206 may cause the radial outer loop wall 208 to be radially pulled into the direction of the optical component or translated in the direction of the optical component (see [reference]). Figure 2B These unexpected shape changes may lead to undesirable side effects, such as unexpected changes in optical power and reduced accommodation performance.

[0159] Therefore, the technical problem faced by the applicants is how to counteract or reduce the effects of these unintended loop shape changes caused by the application of laser 125 without interfering with the ability to fine-tune the base focal length of the IOL through changes in fluid pressure induced by the laser (i.e., without interfering with the ability to adjust the optical power of the lens after implantation) and without interfering with the sensitivity of the fluid-filled loop 104 to the radial force exerted on the capsular bag due to ciliary muscle movement (i.e., without interfering with the lens's accommodative ability). The technical solution discovered and developed by the applicants is the loop spacer 105 disclosed herein.

[0160] Figure 2B The figure shows measurements taken in response to a laser 125 directed at such a loop, of the movement of the radial outer wall 208 of a loop 200 without a loop separator 105 and of the movement of the radial outer wall 118 of a loop 104 with a loop separator 105.

[0161] Figure 2B Measurements of movement or displacement of the radial outer wall of a loop are demonstrated using an Integrated Data Acquisition System (IDAS). Finite element analysis (FEA) modeling is also used to predict such movement. For both types of loops, laser 125 ( Figure 2B (Not shown) Points to or otherwise passes to the lumen filling of such loops.

[0162] Figure 2BThe outer contours of the two loops before laser application are shown using dashed lines, and the outer contours after laser application are shown using solid lines. As can be seen from these depictions of the outer contours, the two loops respond differently to the application of laser 125.

[0163] Without the isolation loop 200, the laser 125 points towards the internal cavity expander. Figure 2B (Not shown in the image) This causes the front wall 204 of the loop 200 to expand in the forward direction and the rear wall 206 of the loop 200 to expand in the rearward direction. In most cases, this expansion causes the radial outer wall 208 of the loop 200 to be radially pulled into the direction of the optical component or translated in the direction of the optical component. Figure 2B (Not shown in the image).

[0164] As in Figure 2B As can be seen in the figure, the radial outer wall 208 of loop 200 is displaced by an average of approximately 0.03 mm or 30 micrometers in the radially inward direction (where negative values ​​in the figure indicate radially inward movement). In some cases, the radial outer wall 208 of loop 200 has been measured to have moved radially inward by up to almost 0.10 mm or 100 micrometers. This degree of displacement is considered problematic because it counteracts the desired expansion of the loop lumen.

[0165] Different responses to laser 125 are observed in loop 104 having loop separator 105. Laser 125 is applied to the cavity expansion of such loop 104 ( Figure 2B (Not shown in the image) Subsequent IDAS measurements of this type of loop showed that the radial outer wall 208 of loop 104 moved much less.

[0166] As in Figure 2B As can be seen in the figure, the radial outer wall 118 of loop 104 is displaced by an average of approximately 0.01 mm or 10 micrometers in the radially outward direction (where positive values ​​in the figure indicate radially outward movement). In some cases, the radial outer wall 118 of loop 104 is not shown to have moved. In most cases, the radial outer wall 118 of loop 104 moves only 0 mm to 0.01 mm or 10 micrometers in either the radially outward or radially inward direction.

[0167] therefore, Figure 2B It is demonstrated that the loop isolator 105 can effectively limit any radial movement of the radial outer wall 118 of the loop in response to a laser 125 directed at the loop 104. For example, the loop isolator 105 can effectively limit any radial movement of the radial outer wall 118 of the loop to between 0 and 0.01 mm (or 10 micrometers) in response to a laser 125 directed at the loop 104.

[0168] Figure 3A cross-sectional view of an embodiment of a loop 104 having a loop separator 105 disposed within a loop cavity 106 is shown. The loop separator 105 may be configured to maintain the shape of the loop cavity 106 in response to laser energy (e.g., laser 125) applied to or transmitted to the loop 104 in order to adjust the base focal length of the optical portion 102.

[0169] The loop separator 105 can extend from the anterior wall 300 of the loop to the posterior wall 302 of the loop. For example... Figure 3 As shown, the loop separator 105 can be aligned in the front-to-back direction such that the loop separator 105 is substantially parallel to the optical axis 142 of the optical component portion 102 (see example). Figure 1B and Figure 1C ).

[0170] In other embodiments not shown in the figures but contemplated by this disclosure, the loop separator 105 may be tilted or skewed. For example, the loop separator 105 may be positioned at an angle relative to the optical axis 142.

[0171] like Figure 3 As shown, the loop separator 105 can be positioned radially closer to the loop inner wall 120 than the loop outer wall 118 (see also...). Figure 1B and Figure 1C This allows the loop separator 105 to counteract or reduce the effects of unintended loop shape changes caused by the application of laser 125, without substantially affecting the sensitivity of the radial outer wall 118 of the loop to radial forces applied to the pouch via ciliary muscle movement.

[0172] For example, loop spacer 105 (or the side of loop spacer 105 closest to the radial inner wall 120 of the loop) can be separated from the radial inner wall 120 by an inner separation distance of 304. Loop spacer 105 (or the other side of loop spacer 105 closest to the radial outer wall 118 of the loop) can be separated from the radial outer wall 118 by an outer separation distance of 306. The outer separation distance 306 can be greater than the inner separation distance 304.

[0173] In some embodiments, the outer separation distance may be 1.5 times (1.5X) to three times (3X) the inner separation distance 304. In other embodiments, the outer separation distance may be 1.2 times (1.2X) to 1.4 times (1.4X) the inner separation distance 304. In yet another embodiment, the outer separation distance may be three times (3X) to four times (4X) the inner separation distance 304.

[0174] In some embodiments, the loop spacer 105 may be positioned between the radial inner wall 120 of the loop and the center line that bisects the loop cavity 106 in the radial direction. For example, the loop spacer 105 may be positioned radially inside the center line that bisects the loop cavity 106 in the radial direction.

[0175] In some embodiments, the loop spacer 105 may be cylindrical or shaped as a circular cylinder. In other embodiments, the loop spacer 105 may be shaped as an elongated cuboid or square prism, an elongated truncated cone, a triangular prism, or an elongated ellipse (i.e., having an elliptical cross-section).

[0176] In some embodiments, the loop separator 105 may be made of the same material as the rest of the loop 104. For example, the loop separator 105 may be made of the same crosslinked copolymer as the wall of the loop 104. In some embodiments, the loop separator 105 may be integrated with the rest of the loop 104.

[0177] In some embodiments, the loop spacer 105 may be formed or generated during the loop casting process. For example, the entire loop 104 (including the loop spacer 105) may be formed by injection molding.

[0178] The loop spacer 105 may have a spacer height 308 and a spacer width 310 or diameter (if the loop spacer 105 is cylindrical).

[0179] In some embodiments, the height of the spacer 308 may be between approximately 1.5 mm and 2.00 mm. For example, the height of the spacer 308 may be between approximately 1.75 mm and 1.85 mm (e.g., approximately 1.84 mm).

[0180] In some embodiments, the width or diameter of the spacer 310 may be between approximately 0.20 mm and 0.60 mm. For example, the width of the spacer 310 may be between approximately 0.30 mm and 0.50 mm (e.g., approximately 0.35 mm).

[0181] In other embodiments, depending on the width of the loop cavity 106, the width 310 or diameter of the spacer can be greater than 0.60 mm. In yet another embodiment, depending on the width of the loop cavity 106, the width 310 or diameter of the spacer can be less than 0.20 mm.

[0182] In some embodiments, the height 308 or length of the barrier may be approximately twice the width 310 or diameter of the barrier. In other embodiments, the height 308 or length of the barrier may be greater than twice the width 310 or diameter of the barrier.

[0183] In some embodiments, the ratio of the height 308 of the spacer to the width 310 or diameter of the spacer can be between approximately 3:1 and 10:1. For example, the ratio of the height 308 of the spacer to the width 310 or diameter of the spacer can be between approximately 4:1 and 6:1 (e.g., approximately 5:1).

[0184] like Figure 3As shown, the width 310 of the spacer can remain constant along the length or height of the loop spacer 105. In other embodiments, the width 310 of the spacer can be larger than the rest of the loop spacer 105 near the ends of the loop spacer 105 (i.e., closer to the front wall 300 and the rear wall 302 of the loop).

[0185] In other embodiments, each loop spacer 105 may include a spacer front end 312, a spacer rear end 314, and a spacer segment 316 between the spacer front end 312 and the spacer rear end 314. In these embodiments (see, for example...) Figure 6 The width or diameter of at least one of the front end 312 and the rear end 314 of the barrier may be greater than the barrier segment 316 between the front end 312 and the rear end 314. For example, the loop barrier 105 may widen or open at the front end 312 and / or the rear end 314 of the barrier.

[0186] although Figure 3 Only one loop spacer 105 within the loop cavity 106 is shown, but it is contemplated that the loop cavity 106 may include a plurality of loop spacers 105 positioned along at least a portion of the length or segment of the loop cavity 106.

[0187] One technical problem faced by the applicants is how to counteract or reduce the effects of unintended loop shape changes caused by the application of laser 125. The technical solution discovered and developed by the applicants is the loop spacer 105 disclosed herein, which is disposed within the loop cavity 106 and positioned radially closer to the loop inner wall 120 than the loop outer wall 118 (see also...). Figure 1B , Figure 1C , Figure 4A and Figure 4B ).

[0188] The loop spacer 105 can act as a three-dimensional support or pillar to prevent accidental deformation of the loop cavity 106. For example, the loop spacer 105 can prevent accidental expansion and / or contraction of the loop cavity 106 caused by the application of laser energy to the composite material.

[0189] Figure 4A A perspective view of one embodiment of a loop 104 including multiple loop spacers 105 is shown, with the front portion of the loop 104 removed for observation. As previously discussed, the loop spacers 105 can be configured to counteract or reduce any unintended shape changes caused by the laser 125 directed at the cavity filler 126 and / or cavity expander 128, in order to fine-tune the base focal power of the IOL 100.

[0190] like Figure 4AAs shown, the loop separator 105 can be designed as a column or a cylindrical column, each column having a substantially circular cross-section.

[0191] In other embodiments, at least a portion of the loop separator 105 may have a substantially triangular, rectangular, or other polygonal cross-section. In yet another embodiment, at least a portion of the loop separator 105 may have a substantially elliptical cross-section.

[0192] like Figure 4A As shown, the loop spacer 105 can be positioned within the loop cavity 106. The loop spacer 105 can be positioned or placed such that the sides of the loop spacer 105 do not physically contact the outer radial wall 118 or the inner radial wall 120 of the loop. Furthermore, as... Figure 4A As shown, the loop separator 105 can be positioned or placed closer to the loop inner wall 120 in the radial direction than the outer radial wall 118 of the loop.

[0193] In addition, such as Figure 4A The depicted plurality of loop spacers 105 can be arranged as a curved column within the loop cavity 106. For example, the loop spacers 105 can be arranged in an arc shape.

[0194] In some embodiments, the loop spacers 105 may be positioned at fixed intervals along the length of the loop cavity 106. In other embodiments, the loop spacers 105 may be positioned at variable distances from each other along the length of the loop cavity 106.

[0195] although Figure 4A A loop 104 comprising thirteen loop spacers 105 is shown, but it is contemplated that a loop 104 may comprise three to twenty loop spacers 105 (or twenty to thirty loop spacers 105).

[0196] The loop separator 105 can be made of the same loop material used to manufacture the loop wall. For example... Figure 4A As shown, the loop separator 105 is not made of the composite material used to manufacture the lumen filler 126 and / or lumen expander 128.

[0197] Figure 4B A top plan view of another embodiment of the loop 104, including the loop separator 105, is shown. Figure 4B In the illustrated embodiment, loop 104 includes seven loop spacers 105. As previously discussed, a loop 104 may include three to a maximum of twenty loop spacers 105 (or twenty to thirty loop spacers 105).

[0198] like Figure 4BAs shown, the loop spacer 105 can be arranged in an arc shape 400 or in an arc form. When the loop spacer 105 is arranged in an arc shape 400, it can include a farthest loop spacer 402 and a nearest loop spacer 404. The arc shape 400 can be measured by the central angle or arc angle 406 spanning from the farthest loop spacer 402 to the nearest loop spacer 404. In some embodiments, the central angle or arc angle can be between 70 degrees and 74 degrees.

[0199] Figure 5A A perspective view of one embodiment of the loop 104 of the IOL 100 including the loop separator 105 is shown. Figure 5B A loop 104 is shown, with the distal end 116 of the loop 104 removed to show a cross-section of the loop 104.

[0200] like Figure 5A and Figure 5B As shown, the proximal attachment end 114 of the loop 104 may terminate at a substantially flat interface surface 500. The flat interface surface 500 allows the loop 104 to adhere to or otherwise attach to a corresponding interface surface (also a flat surface) protruding from the reinforcing portion 112 of the optical element portion 102. In some embodiments, the loop 104 may be attached to or adhered to the optical element portion 102 via the same biocompatible adhesive 150 used for attaching the front element 130 to the rear element 132.

[0201] The corresponding interface surface can extend radially outward from the optical component portion 102. For example, the corresponding interface surface can extend radially outward beyond the outer peripheral surface 122 of the optical component portion 102 (e.g., extending radially outward beyond the outer peripheral surface 122 of the optical component portion 102 by about 10 micrometers to 1.0 mm).

[0202] Figure 5A and Figure 5B It is also shown that a substantially flat interface surface 500 can define a loop fluid port 502. The loop fluid port 502 can be an opening serving as the proximal end of the loop cavity 106. When the flat interface surface 500 of the loop 104 is coupled to a corresponding interface surface of the optical component portion 102, the loop fluid port 502 can be fluidly connected to or in fluid communication with one or more externally facing orifices serving as the terminals of the fluid channel 110. Fluid (e.g., silicone oil) entering the optical component fluid chamber 108 can exit the loop cavity 106 through the loop fluid port 502 and enter the fluid channel 110. Furthermore, fluid exiting the optical component fluid chamber 108 can enter the loop cavity 106 through the loop fluid port 502.

[0203] although Figure 5BOnly one loop spacer 105 within the loop cavity 106 is shown; however, it is contemplated that the loop cavity 106 may include a plurality of loop spacers 105 positioned along the length or segment of the loop cavity 106. In some embodiments, the loop spacers 105 may be positioned at fixed intervals along the length of the loop cavity 106. In other embodiments, the loop spacers 105 may be positioned at variable distances from each other along the length of the loop cavity 106.

[0204] Figure 6 This is a computed tomography (CT) scan image of a portion of a loop 104, which includes multiple loop separators 105. In this CT scan image, the radial outer wall 118 of the loop 104 has been digitally removed for observation.

[0205] like Figure 6 As shown, the loop spacer 105 is positioned within the loop cavity 106 and extends in a substantially axial direction (i.e., substantially parallel to the optical axis 142 of the lens). The loop spacer 105 can extend from the anterior wall 300 of the loop to the posterior wall 302 of the loop.

[0206] As shown in this example embodiment, the loop spacers 105 may be substantially cylindrical, such that each loop spacer 105 has a substantially circular cross-section. When the loop spacers 105 are arranged as columns, the loop spacers 105 may be arranged as a curved column array within the loop cavity 106.

[0207] In some embodiments, the loop spacers 105 may be positioned at fixed intervals along the length of the loop cavity 106. In other embodiments, the distance separating adjacent loop spacers 105 may vary along the length of the loop cavity 106.

[0208] also, Figure 6 It is shown that the width or diameter of one or more loop spacers 105 may be larger or more open near the ends of the loop spacers 105 (i.e., closer to the front wall 300 and the rear wall 302 of the loop) than the rest of the loop spacers 105.

[0209] In other embodiments, the width or diameter of one or more loop spacers 105 may be the same along the entire height or length of the loop spacer 105.

[0210] although Figure 6 A loop 104 comprising ten loop spacers 105 is shown. It is contemplated that a loop 104 may comprise three to a maximum of twenty loop spacers 105 (or twenty to thirty loop spacers 105).

[0211] Figure 7A and Figure 7B A perspective view of an additional embodiment of the loop 104 is shown, which includes a plurality of loop spacers 105 shaped as spacer blocks 700 or plates. Figure 7A and Figure 7B In the middle, the front part of each loop 104 is not shown for easy observation.

[0212] In some embodiments, the isolation block 700 may have a non-circular cross-section. For example, each isolation block 700 may have a cross-sectional profile 702 including a block length dimension 704 and a block width dimension 706. The block length dimension 704 of the cross-sectional profile 702 may be greater than the block width dimension 706.

[0213] In some embodiments, the block length dimension 704 of the cross-sectional profile 702 may be twice the block width dimension 706. In other embodiments, the block length dimension 704 of the cross-sectional profile 702 may be greater than twice the block width dimension 706 (e.g., between 3X and 5X).

[0214] Each isolation block 700 may also have a block height dimension 708. In some embodiments, the block height dimension 708 may be between approximately 1.5 mm and 2.00 mm. For example, the block height dimension 708 may be between approximately 1.75 mm and 1.85 mm (e.g., approximately 1.84 mm).

[0215] In some embodiments, the block width dimension 706 may be between approximately 0.20 mm and 0.60 mm. For example, the block width dimension 706 may be between approximately 0.30 mm and 0.50 mm (e.g., approximately 0.35 mm).

[0216] In other embodiments, the block width dimension 706 may be greater than 0.60 mm, depending on the width of the loop cavity 106. In yet another embodiment, the block width dimension 706 may be less than 0.20 mm, depending on the width of the loop cavity 106.

[0217] In some embodiments, the block height dimension 708 may be approximately twice the block width dimension 706. In other embodiments, the block height dimension 708 may be greater than twice the block width dimension 706.

[0218] In some embodiments, the ratio of block height dimension 708 to block width dimension 706 can be between approximately 3:1 and 10:1. For example, the ratio of block height dimension 708 to block width dimension 706 can be between approximately 4:1 and 6:1 (e.g., approximately 5:1).

[0219] In some embodiments, the cross-sectional profile 702 of at least one of the isolation blocks 700 may be substantially oblong (i.e., a rectangle with semi-circular ends). In other embodiments, the cross-sectional profile 702 of at least one of the isolation blocks 700 may be substantially elliptical. In still other embodiments, the cross-sectional profile 702 of at least one of the isolation blocks 700 may be substantially rectangular or a rectangle with rounded corners.

[0220] Similar to Figure 1A-1C The loop separator 105 shown in 3, 4A-4B, 5B and 6, the separator block 700 can be configured to counteract or reduce any unintended shape changes caused by the laser 125 pointing towards the cavity filler 126 and / or cavity expander 128, in order to fine-tune the base focal length of the IOL 100.

[0221] like Figure 7A and Figure 7B As shown, the spacer block 700 can be positioned within the loop cavity 106. The spacer block 700 can be positioned or placed such that none of its sides physically contact the outer radial wall 118 or the inner radial wall 120 of the loop. Furthermore, as... Figure 7A and Figure 7B As shown, the isolation block 700 can be positioned or placed closer to the radial inner wall 120 of the loop than the radial outer wall 118 of the loop.

[0222] In addition, such as Figure 7A and Figure 7B The multiple isolation blocks 700 depicted can be arranged in an arc shape or as a curved column within the loop cavity 106.

[0223] In some embodiments, the spacer blocks 700 may be positioned at fixed intervals along the length of the loop cavity 106. In other embodiments, the spacer blocks 700 may be positioned at variable distances from each other along the length of the loop cavity 106.

[0224] although Figure 7A The loop 104, which includes three isolation blocks 700, was shown. Figure 7B A loop 104 comprising four isolation blocks 700 is shown, but this disclosure envisions that a loop 104 may comprise three to a maximum of twenty isolation blocks 700 (or twenty to thirty isolation blocks 700).

[0225] The separator 700 can be made of the same loop material used to manufacture the loop wall. For example... Figure 7A and Figure 7B As shown, the isolation block 700 is not made of the composite material used to manufacture the cavity filler 126 and / or cavity expander 128.

[0226] This disclosure also covers the following provisions:

[0227] Clause 1. An intraocular lens comprising: an optical portion including an optical fluid chamber; a loop having a proximal end and a distal end connected to the optical portion, wherein the loop includes a loop cavity extending through at least a portion of the loop and in fluid communication with the optical fluid chamber; and a plurality of loop spacers disposed within the loop cavity.

[0228] Clause 2. The intraocular lens as described in Clause 1, wherein the loop cavity is surrounded by a radially outer wall, a radially inner wall, an anterior wall, and a posterior wall.

[0229] Clause 3. An intraocular lens as described in Clause 2, wherein the loop isolator is configured to limit any radial movement of the radial outer wall of the loop to between 0 and 10 micrometers in response to a laser beam directed at the loop.

[0230] Clause 4. The intraocular lens as described in Clause 2, wherein the loop spacer extends from the anterior wall of the loop to the posterior wall of the loop.

[0231] Clause 5. The intraocular lens as described in Clause 2, wherein each of the loop spacers includes a side surface, and wherein the side surface of the loop spacer does not physically contact the radial inner wall or the radial outer wall of the loop.

[0232] Clause 6. The intraocular lens as described in Clause 2, wherein the loop spacer is positioned radially closer to the radial inner wall of the loop than to the radial outer wall of the loop.

[0233] Clause 7. The intraocular lens as described in Clause 6, wherein the side of at least one of the loop spacers closest to the radial inner wall of the loop is separated from the radial inner wall of the loop by an inner separation distance, wherein the other side of the loop spacer closest to the radial outer wall of the loop is separated from the radial outer wall of the loop by an outer separation distance, and wherein the outer separation distance is 1.5X to 3X of the inner separation distance.

[0234] Clause 8. The intraocular lens as described in Clause 1, wherein at least one of the loop spacers is configured as a column.

[0235] Clause 9. An intraocular lens as described in Clause 8, wherein the column has a substantially circular cross-section.

[0236] Clause 10. The intraocular lens as described in Clause 1, wherein at least one of the loop spacers has a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0237] Clause 11. The intraocular lens as described in Clause 1, wherein the plurality of loop spacers are arranged as a curved column array within the loop cavity.

[0238] Clause 12. The intraocular lens as described in Clause 1, wherein the plurality of loop spacers are positioned at fixed intervals along at least a portion of the inner lumen of the loop.

[0239] Clause 13. The intraocular lens as described in Clause 1, wherein the loop comprises between three and twenty loop spacers.

[0240] Clause 14. The intraocular lens as described in Clause 1, wherein each of the loop spacers includes a spacer front end, a spacer rear end, and a spacer segment between the spacer front end and the spacer rear end, wherein the width or diameter of at least one of the spacer front end and the spacer rear end is greater than the spacer segment between the spacer front end and the spacer rear end.

[0241] Clause 15. The intraocular lens as described in Clause 1, wherein the width or diameter of at least one of the loop spacers remains constant along the length or height of the loop spacer.

[0242] Clause 16. The intraocular lens as described in Clause 1, wherein each of the loop spacers can be measured by spacer width or diameter and spacer length or height, and wherein the spacer length or height of at least one of the loop spacers is greater than twice the spacer width or diameter.

[0243] Clause 17. The intraocular lens as described in Clause 1, wherein the loop spacers are arranged in an arcuate shape, wherein the loop spacers include a distal loop spacer and a proximal loop spacer serving as endpoints of the arcuate shape, wherein the arcuate shape can be measured by a central angle or an arcuate angle, and wherein the central angle or arcuate angle is between 70 degrees and 74 degrees.

[0244] Clause 18. The intraocular lens as described in Clause 1, wherein the loop comprises at least one of an inner cavity filler and an inner cavity dilator made of a composite material, wherein the composite material is configured to dilate in response to receiving a laser beam directed at the inner cavity filler or the inner cavity dilator, and wherein the loop separator is not made of the composite material.

[0245] Clause 19. The intraocular lens as described in Clause 1, wherein the loop spacer is made of the same material as one or more walls of the loop.

[0246] Clause 20. An intraocular lens comprising: an optical portion; a loop having a proximal end and a distal end connected to the optical portion, wherein the loop includes a loop cavity extending through at least a portion of the loop; and a plurality of loop spacers disposed in an arcuate form within the loop cavity.

[0247] Clause 21. The intraocular lens as described in Clause 20, wherein the loop cavity is surrounded by a radially outer wall, a radially inner wall, an anterior wall, and a posterior wall.

[0248] Clause 22. An intraocular lens as described in Clause 21, wherein the loop isolator is configured to limit any radial movement of the radial outer wall of the loop to between 0 and 10 micrometers in response to a laser beam directed at the loop.

[0249] Clause 23. The intraocular lens as described in Clause 22, wherein the loop comprises at least one of an inner cavity filler and an inner cavity dilator made of a composite material, wherein the composite material is configured to dilate in response to receiving a laser beam directed at the inner cavity filler or the inner cavity dilator, and wherein the loop separator is not made of the composite material.

[0250] Clause 24. The intraocular lens as described in Clause 21, wherein the loop spacer extends from the anterior wall of the loop to the posterior wall of the loop.

[0251] Clause 25. The intraocular lens as described in Clause 21, wherein each of the loop spacers includes a side surface, and wherein none of the side surfaces of the loop spacers physically contacts the radial inner wall or the radial outer wall of the loop.

[0252] Clause 26. The intraocular lens as described in Clause 21, wherein the loop spacer is positioned radially closer to the radial inner wall of the loop than to the radial outer wall of the loop.

[0253] Clause 27. The intraocular lens as described in Clause 26, wherein the side of at least one of the loop spacers closest to the radial inner wall of the loop is separated from the radial inner wall of the loop by an inner separation distance, wherein the other side of the loop spacer closest to the radial outer wall of the loop is separated from the radial outer wall of the loop by an outer separation distance, wherein the outer separation distance is 1.5X to 3X of the inner separation distance.

[0254] Clause 28. An intraocular lens as described in Clause 20, wherein the loop spacer is made of the same material as one or more walls of the loop.

[0255] Clause 29. The intraocular lens as described in Clause 20, wherein at least one of the loop spacers is configured as a column.

[0256] Clause 30. The intraocular lens as described in Clause 29, wherein the column has a substantially circular cross-section.

[0257] Clause 31. The intraocular lens as described in Clause 20, wherein at least one of the loop spacers has a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

[0258] Clause 32. The intraocular lens as described in Clause 20, wherein the plurality of loop spacers are arranged as a curved column array within the loop cavity.

[0259] Clause 33. The intraocular lens as described in Clause 20, wherein the plurality of loop spacers are positioned at fixed intervals along at least a portion of the inner lumen of the loop.

[0260] Clause 34. An intraocular lens as described in Clause 20, wherein the loop comprises between three and twenty loop spacers.

[0261] Clause 35. The intraocular lens as described in Clause 20, wherein each of the loop spacers includes a spacer front end, a spacer rear end, and a spacer segment between the spacer front end and the spacer rear end, wherein the width or diameter of at least one of the spacer front end and the spacer rear end is greater than the spacer segment between the spacer front end and the spacer rear end.

[0262] Clause 36. The intraocular lens as described in Clause 20, wherein the width or diameter of at least one of the loop spacers remains constant along the length or height of the loop spacer.

[0263] Clause 37. The intraocular lens as described in Clause 20, wherein each of the loop spacers can be measured by spacer width or diameter and spacer length or height, and wherein the spacer length or height of at least one of the loop spacers is greater than twice the spacer width or diameter.

[0264] Clause 38. The intraocular lens as described in Clause 20, wherein the loop separators comprise a distal loop separator and a proximal loop separator serving as endpoints of the arcuate form, wherein the arcuate form can be measured by a central angle or an arcuate angle, and wherein the central angle or arcuate angle is between 70 degrees and 74 degrees.

[0265] Clause 39. An intraocular lens comprising: an optical element portion; a loop having a proximal end and a distal end connected to the optical element portion, wherein the loop includes a loop cavity extending through at least a portion of the loop; and one or more spacers disposed within the loop cavity, wherein at least one of the one or more spacers includes a non-circular cross-section.

[0266] Clause 40. The intraocular lens as described in Clause 39, wherein the loop cavity is surrounded by a radially outer wall, a radially inner wall, an anterior wall, and a posterior wall.

[0267] Clause 41. An intraocular lens as described in Clause 40, wherein the spacer is configured to limit any radial movement of the radial outer wall of the loop to between 0 and 10 micrometers in response to a laser beam directed at the loop.

[0268] Clause 42. The intraocular lens as described in Clause 40, wherein the one or more spacers extend from the anterior wall of the loop to the posterior wall of the loop.

[0269] Clause 43. The intraocular lens as described in Clause 40, wherein each of the one or more spacers includes a side surface, and wherein none of the side surfaces of the one or more spacers physically contacts the radial inner wall or the radial outer wall of the loop.

[0270] Clause 44. The intraocular lens as described in Clause 40, wherein the one or more spacers are positioned radially closer to the radial inner wall of the loop than to the radial outer wall of the loop.

[0271] Clause 45. The intraocular lens as described in Clause 44, wherein the side of at least one of the spacers closest to the radial inner wall of the loop is separated from the radial inner wall of the loop by an inner separation distance, wherein the other side of the spacer closest to the radial outer wall of the loop is separated from the radial outer wall of the loop by an outer separation distance, and wherein the outer separation distance is 1.5X to 3X of the inner separation distance.

[0272] Clause 46. The intraocular lens as described in Clause 39, wherein the loop comprises at least one of an inner cavity filler and an inner cavity dilator made of a composite material, wherein the composite material is configured to dilate in response to receiving a laser beam directed at the inner cavity filler or the inner cavity dilator, and wherein the one or more spacers are not made of the composite material.

[0273] Clause 47. An intraocular lens as described in Clause 39, wherein the one or more spacers are made of the same material as one or more walls of the loop.

[0274] Clause 48. The intraocular lens as described in Clause 39, wherein at least one of the spacers has a substantially oblong cross-section.

[0275] Clause 49. The intraocular lens as described in Clause 39, wherein at least one of the spacers has a substantially rectangular cross-section.

[0276] Clause 50. The intraocular lens as described in Clause 39, wherein at least one of the spacers has a substantially elliptical cross-section.

[0277] Clause 51. The intraocular lens as described in Clause 39, wherein the loop includes a plurality of spacers disposed within the lumen of the loop, and wherein the spacers are positioned at fixed intervals along at least a portion of the lumen of the loop.

[0278] Several embodiments have been described. However, those skilled in the art will understand that various changes and modifications can be made to this disclosure without departing from the spirit and scope of the embodiments. Elements of the systems, apparatuses, devices, and methods shown with any embodiments are exemplary for particular embodiments and can be used in combination or otherwise in other embodiments within this disclosure. For example, steps of any method depicted in the figures or described in this disclosure do not require the specific order or sequence shown or described to achieve the desired result. Additionally, other steps may be provided, or steps or operations may be eliminated or omitted from the described methods or processes to achieve the desired result. Furthermore, any component or portion of any device or system described in this disclosure or depicted in the figures may be removed, eliminated, or omitted to achieve the desired result. Additionally, for brevity and clarity, certain components or portions of the systems, apparatuses, or devices shown or described herein have been omitted.

[0279] Accordingly, other embodiments are within the scope of the following claims, and the description and / or drawings may be considered illustrative rather than restrictive.

[0280] Each of the individual variations or embodiments described and illustrated herein has discrete components and features that can be readily separated from or combined with features of any of the other variations or embodiments. Modifications may be made to suit particular circumstances, materials, composition, processes, process actions, or steps to the objectives, spirit, or scope of the invention.

[0281] The methods described herein can be performed in any logically possible order of the events described, as well as in the order of the events themselves. Furthermore, additional steps or operations may be provided, or steps or operations may be eliminated to achieve the desired result.

[0282] Furthermore, where a range of values ​​is provided, every intermediate value between the upper and lower limits of that range, as well as any other statement or intermediate value within that range, is covered within the scope of this invention. Moreover, any optional features of the described inventive variations may be set forth and claimed independently or in combination with any one or more features described herein. For example, the description of ranges 1 to 5 should be considered as having disclosed subranges (such as 1 to 3, 1 to 4, 2 to 4, 2 to 5, 3 to 5, etc.) and individual numbers within that range (e.g., 1.5, 2.5, etc.) and any overall or partial increments therebetween.

[0283] All existing subjects mentioned herein (e.g., publications, patents, patent applications) are incorporated herein by reference in their entirety, except where such subject matter might conflict with the subject matter of this invention (in which case the content herein shall prevail). Items cited are provided only because they were disclosed prior to the filing date of this application. Nothing herein should be construed as an admission that this invention is not entitled to precedence over such material by virtue of a prior invention.

[0284] References to singular items include the possibility that multiple identical items exist. More specifically, as used herein and in the appended claims, the singular forms “a / an,” “the,” and “the” include the plural referents unless the context clearly indicates otherwise. It should be further noted that claims may be drafted to exclude any optional elements. Thus, this statement is intended to serve as a prior basis for the use of exclusive terms such as “only,” “merely,” etc., when referring to claim elements or using the “negative” limitation. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0285] The phrase “at least one of…” refers to any combination of one or more of those items or components when such a phrase modifies multiple items or components (or an enumerated list of items or components). For example, the phrase “at least one of A, B, and C” means: (i) A; (ii) B; (iii) C; (iv) A, B, and C; (v) A and B; (vi) B and C; or (vii) A and C.

[0286] In understanding the scope of this disclosure, the term "comprising" and its derivatives, as used herein, are intended to be open-ended terms that indicate the presence of stated features, elements, components, groups, integers, and / or steps, but do not exclude the presence of other unstated features, elements, components, groups, integers, and / or steps. The foregoing also applies to words with similar meanings, such as the terms "comprising," "having," and their derivatives. Furthermore, the terms "section," "section," "part," "component," "element," or "part" when used in the singular can have a dual meaning of a single part or multiple parts. As used herein, the following directional terms "forward, backward, above, downward, vertical, horizontal, below, lateral, sideways, and vertical," and any other similar directional terms, refer to those positions of the device or equipment or those directions in which the device or equipment is translated or moved.

[0287] Finally, degree terms as used herein (such as “substantially,” “about,” and “approximately”) refer to a specified value or a specified value plus a reasonable amount of deviation from the specified value (e.g., a deviation of up to ±0.1%, ±1%, ±5%, or ±10%, as such variation is appropriate) such that the final result is not significantly or substantially altered. For example, “about 1.0 cm” could be interpreted as meaning “1.0 cm” or between “0.9 cm and 1.1 cm.” When degree terms (such as “about” or “approximately”) are used to refer to numbers or values ​​that are part of a range, the term can be used to modify both the minimum and maximum numbers or values.

[0288] This disclosure is not intended to be limited to the specific forms set forth, but rather to cover alternatives, modifications, and equivalents of the variations or embodiments described herein. Furthermore, the scope of this disclosure fully encompasses other variations or embodiments that may become apparent to those skilled in the art in light of this disclosure.

Claims

1. An intraocular lens comprising: The optical components, including the optical fluid chamber; The optical component has a loop connecting a proximal end and a distal end to the optical component portion, wherein the loop includes a loop cavity extending through at least a portion of the loop and in fluid communication with the fluid chamber of the optical component. as well as Multiple loop separators are disposed within the inner cavity of the loop.

2. The intraocular lens as described in claim 1, wherein, The loop cavity is surrounded by the outer radial wall, the inner radial wall, the front wall, and the rear wall.

3. The intraocular lens as described in claim 2, wherein, The loop isolator is configured to limit any radial movement of the outer radial wall of the loop to between 0 and 10 micrometers in response to a laser beam directed at the loop.

4. The intraocular lens as described in claim 2, wherein, The loop separator extends from the front wall of the loop to the rear wall of the loop.

5. The intraocular lens as described in claim 2, wherein, Each of the loop separators includes a side surface, wherein the side surface of the loop separator does not physically contact the radial inner wall or the radial outer wall of the loop.

6. The intraocular lens as claimed in claim 2, wherein, The loop separator is positioned radially closer to the radial inner wall of the loop than to the radial outer wall of the loop.

7. The intraocular lens as described in claim 6, wherein, At least one of the loop separators has its side closest to the radial inner wall of the loop separated from the radial inner wall of the loop by an inner separation distance, wherein the other side of the loop separator closest to the radial outer wall of the loop is separated from the radial outer wall of the loop by an outer separation distance, and wherein the outer separation distance is 1.5 to 3 times the inner separation distance.

8. The intraocular lens as claimed in claim 1, wherein, At least one of the loop separators is configured as a pillar.

9. The intraocular lens of claim 8, wherein, The column has a substantially circular cross-section.

10. The intraocular lens of claim 1, wherein, At least one of the loop separators has a substantially rectangular cross-section, a substantially triangular cross-section, or a substantially elliptical cross-section.

11. The intraocular lens of claim 1, wherein, The plurality of loop separators are arranged as a series of curved columns within the loop cavity.

12. The intraocular lens of claim 1, wherein, The plurality of loop spacers are positioned at fixed intervals along at least a segment of the inner cavity of the loop.

13. The intraocular lens of claim 1, wherein, The loops include loop separators between three and twenty.

14. The intraocular lens of claim 1, wherein, Each of the loop separators includes a front separator front end, a rear separator rear end, and a separator segment between the front separator front end and the rear separator rear end, wherein at least one of the front separator front end and the rear separator rear end has a width or diameter greater than the separator segment between the front separator front end and the rear separator rear end.

15. The intraocular lens of claim 1, wherein, The width or diameter of at least one of the loop separators remains constant along the length or height of the loop separator.

16. The intraocular lens of claim 1, wherein, Each of the loop separators can be measured by its width or diameter and its length or height, and wherein the length or height of at least one of the loop separators is greater than twice the width or diameter of the separator.

17. The intraocular lens of claim 1, wherein, The loop separators are arranged in an arc shape, wherein the loop separators include a farthest loop separator and a nearest loop separator serving as the endpoints of the arc, wherein the arc can be measured by a central angle or an arc angle, and wherein the central angle or arc angle is between 70 degrees and 74 degrees.

18. The intraocular lens of claim 1, wherein, The loop includes at least one of an inner cavity filler and an inner cavity expander made of a composite material, wherein the composite material is configured to expand in response to receiving a laser beam directed at the inner cavity filler or the inner cavity expander, and wherein the loop separator is not made of the composite material.

19. An intraocular lens comprising: Optical components; A loop having a proximal end and a distal end connected to the optical component portion, wherein the loop includes a loop cavity extending through at least a portion of the loop; as well as Multiple loop separators are arranged in an arc shape within the inner cavity of the loop.

20. An intraocular lens comprising: Optical components; A loop having a proximal end and a distal end connected to the optical component portion, wherein the loop includes a loop cavity extending through at least a portion of the loop; as well as One or more isolation blocks are disposed within the inner cavity of the loop, wherein at least one of the one or more isolation blocks has a non-circular cross-section.

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