Blood vessel quick connection structure for experimental animal organ transplantation

Abstract

The invention provides a blood vessel quick connection structure for experimental animal organ transplantation, and relates to the field of animal experiment instruments. The blood vessel quick connection structure for experimental animal organ transplantation comprises a sleeve and a sleeve handle arranged at one end of the sleeve, and the sleeve is of a hollow columnar structure; the sleeve handle is of an arc-shaped sheet structure with the same radian as the sleeve, and one end of the sleeve handle is connected with part of the circumference of one end of the sleeve. A stable supporting point can be provided for extroversion and knotting of the blood vessel during blood vessel connection, so that the blood vessel can be rapidly and stably connected during an operation, the operation is simple and convenient, and the operation efficiency is greatly improved.

Description

Technical Field

[0001] This invention relates to the technical field of animal experimental instruments, and more specifically, to a quick-connect vascular structure for organ transplantation in experimental animals. Background Technology

[0002] In biomedical research and drug experiments, connecting blood vessels is a common and crucial step in organ transplantation in rodents (such as rats and mice).

[0003] Existing techniques for connecting blood vessels in laboratory animals generally employ a cannula structure. During the procedure, one blood vessel is first passed through the cannula and then turned outwards and ligated outside the cannula. Then, the other blood vessel is passed through the turned-out blood vessel and tied to complete the connection.

[0004] However, the existing cannula structure has some defects: when the blood vessel passes through the sleeve and is everted and knotted, it is not possible to effectively fix the blood vessel and the cannula, which can lead to problems such as not being able to exert force to tie the knot, or the knot being tied off-center; in addition, doctors need to use a knotting rope to tie the knot, which is cumbersome and complicated, and it is easy to tie the knot loosely, which can lead to the blood vessel falling off. Summary of the Invention

[0005] To address at least one of the technical problems in the prior art, embodiments of the present invention provide a quick-connect structure for vascular transplantation in experimental animals, which can provide stable support points for vascular eversion and knotting during vascular connection, thereby achieving rapid and stable intraoperative vascular connection.

[0006] The technical solution adopted in this invention is to provide a quick-connect structure for vascular transplantation of experimental animal organs, including a sleeve and a sleeve handle disposed at one end of the sleeve. The sleeve is a hollow columnar structure; the sleeve handle is an arc-shaped sheet structure with the same curvature as the sleeve, and one end of the sleeve handle is partially circumferentially connected to one end of the sleeve.

[0007] Furthermore, in this invention, the width of the sleeve arm is gradually reduced along the direction away from the sleeve tube, and ends in an arc at the far end of the sleeve arm.

[0008] Furthermore, in this invention, the arc length of the end of the sleeve handle near the sleeve tube is 1 / 4 to 1 / 2 of the circumference of the sleeve tube.

[0009] Furthermore, in this invention, the outer wall of the end of the sleeve tube away from the sleeve handle is provided with external threads.

[0010] Furthermore, in this invention, at least two guide wings are provided at the end of the sleeve tube away from the sleeve handle, and the two guide wings are symmetrically arranged along the radial direction of the sleeve tube; each guide wing is folded outward in an arc shape from the inner wall of the sleeve tube to the outer wall of the sleeve tube and is movably engaged with the outer wall of the sleeve tube; wherein, the guide wings are made of superelastic nickel-titanium alloy.

[0011] Furthermore, in this invention, four guide vanes are provided, and the four guide vanes are evenly spaced along the circumference of the sleeve.

[0012] Furthermore, in this invention, a locking ring is provided on the outside of the sleeve tube. The locking ring includes a connecting part and a locking part integrally connected along the axial direction of the sleeve tube. The connecting part is threaded to the outer wall of the sleeve tube. The locking part is close to the guide wing relative to the connecting part. The locking part has a conical structure that expands toward the guide wing. The maximum expansion width of the conical structure is less than the maximum distance between the two oppositely arranged guide wing pieces.

[0013] Furthermore, in this invention, the aforementioned guide wing forms a tapered guide inlet at the end of the aforementioned sleeve for guiding the docked blood vessel into place.

[0014] Furthermore, in this invention, the length of the sleeve tube is 2mm to 3mm, the length of the sleeve arm is 1.5mm to 2.5mm, and the length of the sleeve tube is greater than the length of the sleeve arm.

[0015] Furthermore, in this invention, the length of the guide wing is 0.4mm to 0.6mm, and the distance between the outwardly folded portion of the guide wing and the outer wall of the sleeve is 0.15mm to 0.25mm.

[0016] The present invention has at least the following advantages or beneficial effects:

[0017] This invention utilizes a hollow, cylindrical sleeve designed for passing through blood vessels. A handle, with the same arcuate curvature as the sleeve, is connected to one end of the sleeve. One end of the handle is partially circumferentially connected to the end of the sleeve, creating a force-bearing point extending axially along the sleeve. This facilitates intraoperative clamping and fixation of the blood vessel and sleeve, providing stable support for vessel eversion and knotting. The arcuate structure of the handle does not interfere with vessel passage, and the circumferential connection between the handle and sleeve also facilitates vessel clamping. Furthermore, the structure is simple, easy to manufacture, and convenient to use. This invention provides a stable support point for vessel eversion and knotting during connection, enabling rapid and stable intraoperative vessel connection with simple and convenient operation, significantly improving operational efficiency. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the vascular quick-connect structure for experimental animal organ transplantation provided in Embodiment 1 of the present invention;

[0020] Figure 2 This is a schematic diagram of the vascular quick-connect structure for experimental animal organ transplantation provided in Embodiment 2 of the present invention;

[0021] Figure 3 This is a schematic diagram of the vascular quick-connect structure for experimental animal organ transplantation provided in Embodiment 3 of the present invention;

[0022] Figure 4 This is a schematic diagram of the vascular quick-connect structure for experimental animal organ transplantation provided in Embodiment 4 of the present invention;

[0023] Figure 5 This is a cross-sectional view of the vascular quick-connect structure for experimental animal organ transplantation provided in Embodiment 4 of the present invention.

[0024] In the accompanying drawings, the meanings of the reference numerals are as follows:

[0025] 1. Sleeves;

[0026] 11. External thread;

[0027] 2. Sleeve handle;

[0028] 3. Guiding vanes;

[0029] 31. Guiding entrance;

[0030] 4. Locking ring;

[0031] 41. Connecting part;

[0032] 42. Locking section. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0034] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0035] Example 1

[0036] Please refer to Figure 1 , Figure 1 The diagram shown is a schematic diagram of a vascular quick-connect structure for organ transplantation in experimental animals according to an embodiment of the present invention.

[0037] This embodiment provides a quick-connect vascular graft structure for organ transplantation in experimental animals, including a sleeve 1 and a handle 2 located at one end of the sleeve 1. The sleeve 1 has a hollow cylindrical structure, allowing the blood vessel to pass smoothly through the sleeve 1 during operation, facilitating eversion and knotting. The handle 2 has an arc-shaped sheet structure with the same curvature as the sleeve 1. One end of the handle 2 is partially circumferentially connected to one end of the sleeve 1, forming a handle-like structure at one end of the sleeve 1 that is easy to clamp. During surgery, a vascular clamp can be used to hold it, facilitating eversion and knotting of the passed blood vessel at the other end of the sleeve 1. The arc-shaped sheet structure of the handle 2 matches the circumferential curvature of the sleeve 1 to ensure that it does not obstruct the passage of the blood vessel. One end of the cuff handle 2 is circumferentially connected to a portion of the cuff tube 1 to expose the blood vessel. This allows the cuff handle 2 and the blood vessel to be clamped simultaneously during clamping, thus providing stable support for the eversion and knotting of the blood vessel. This makes the operation quick, convenient, and stable, enabling the eversion and knotting of the blood vessel.

[0038] In a preferred embodiment, the width of the cuff 2 gradually tapers away from the sleeve tube 1 and ends in a rounded arc at the distal end. That is, the cuff 2 is similar in shape to a bullet, tapering from one end to the other, with a smooth transition edge to prevent the edge of the cuff 2 from scratching or puncturing blood vessels.

[0039] In a preferred embodiment, the arc length of the end of the cuff handle 2 closest to the cuff tube 1 is 1 / 4 to 1 / 2 of the circumference of the cuff tube 1, preferably 1 / 3 of the circumference of the cuff tube 1. This avoids the situation where the arc length is too large (exceeding 1 / 2 of the circumference of the cuff tube 1), making it difficult to hold the vascular clamp, which may lead to incomplete clamping and intraoperative blood leakage. Conversely, the situation avoids the situation where the arc length is too small (less than 1 / 4 of the circumference of the cuff tube 1), making the vascular clamp unstable, prone to bending, and difficult to apply force when tying a knot.

[0040] In one specific embodiment, after the blood vessel passes through the sleeve tube 1 from one end of the sleeve handle 2, a blood vessel clamp is used to hold the blood vessel and the sleeve handle 2. Then, the broken end of the blood vessel is turned outward at the other end and tied to the end of the sleeve tube 1 to prevent the blood vessel from falling off. Then, the blood vessels that need to be joined are passed through the stretched outward-turned blood vessel, and after adjusting the position, the two blood vessel segments are firmly tied together to complete the process.

[0041] As a preferred embodiment, the length of the sleeve 1 is 2mm~3mm, the length of the sleeve handle 2 is 1.5mm~2.5mm, and the length of the sleeve 1 is greater than the length of the sleeve handle 2, which is suitable for vascular connection and clamping fixation of experimental animals.

[0042] The above structure is simple, easy to manufacture, and the materials are readily available. Specifically, the sleeve 1 and the handle 2 are made of the same material, polyimide. Taking a 250g rat renal vein as an example, the inner diameter of the sleeve 1 is 1.8mm, the wall thickness is 0.04mm, the main body length of the sleeve 1 is 2.5mm, and the handle 2 is about 2mm long. A 4.5mm cylindrical conduit is cut using spring shears. Then, the position of the 2mm length of the cylindrical conduit is determined, and scissors are cut from the end close to 2mm, removing 2 / 3 of the arc-shaped area, leaving 1 / 3 of the arc-shaped handle structure. The tip of the handle 2 is slightly trimmed into a bullet shape. After the general shape of the sleeve 1 and the handle 2 is determined, an electrocautery pen or other high-temperature cauterization device is used to smooth the end of the sleeve 1 away from the handle 2 and other angular parts to prevent them from cutting the blood vessel.

[0043] Example 2

[0044] Reference Figure 2 , Figure 2 The diagram shown is a schematic diagram of the quick-connect structure for blood vessels in this embodiment. This embodiment is largely the same as Embodiment 1, except that the outer wall of the end of the sleeve 1 furthest from the cuff handle 2 is provided with external threads 11. This allows for a more secure and stable knotting on the sleeve 1 after the blood vessel has turned outwards. Because the knotting cord loops around the sleeve 1 of the outwardly turned blood vessel during knotting, the concave and convex structure of the threads allows the knotting cord to be embedded in the recessed position, making it less prone to slippage and resulting in a more stable ligation.

[0045] Example 3

[0046] Reference Figure 3 , Figure 3The diagram shows a schematic of the quick-connect structure for blood vessels in this embodiment. This embodiment is largely the same as Embodiment 2, except that at least two guide wings 3 are provided at the end of the sleeve 1 furthest from the cuff handle 2. These two guide wings 3 are symmetrically arranged radially along the sleeve 1. The guide wings 3 fold outwards in an arc shape from the inner wall of the sleeve 1 to the outer wall and are movably engaged with it. When a blood vessel passes through one end of the guide wings 3 in the sleeve 1, a negative pressure adsorption effect is generated between the vessel's adventitia and the curved surface of the guide wings 3, guiding the blood vessel to fold outwards and adhere to the guide wings 3, thus assisting in the rapid outward folding and adhesion of the blood vessel to the outer wall of the sleeve 1.

[0047] Among them, the guide wing 3 is made of super-elastic nickel-titanium alloy, which has a low coefficient of friction with blood vessels, guides blood vessels to slide, and is flexible so that the guide wing 3 will not damage blood vessels, while also supporting the outward curvature of blood vessels.

[0048] As a preferred implementation, four guide wings 3 are provided. The four guide wings 3 are evenly distributed along the circumference of the sleeve 1. The four guide wings 3 can be evenly distributed along the circumference of the sleeve 1 to guide and support the blood vessels around them, so that the blood vessels can be quickly turned outward to the outside of the sleeve 1.

[0049] In a preferred embodiment, the end of the guide wing 3 located outside the sleeve tube 1 can be engaged in a slot on the outer wall of the sleeve tube 1. By inserting the end of the guide wing 3 into the slot and then closing a portion of the width of the slot in the middle to limit it inside the slot, the end of the guide wing 3 can be movably engaged outside the sleeve tube 1, so that the guide wing 3 can have a certain displacement when pressed, without being damaged.

[0050] Example 4

[0051] Reference Figure 4 , Figure 4 The diagram shown is a structural schematic of the vascular quick-connect structure in this embodiment, and is illustrated in conjunction with reference to... Figure 5 , Figure 5The diagram shows a cross-sectional view of the quick-connect structure for blood vessels in this embodiment. This embodiment is largely the same as Embodiment 2, except that a locking ring 4 is fitted over the cuff 1. The locking ring 4 includes a connecting portion 41 and a locking portion 42 integrally connected along the axial direction of the cuff 1. The connecting portion 41 is threaded to the outer wall of the cuff 1 and can move axially along the outer wall of the cuff 1 by rotation. The locking portion 42 is closer to the guide wing 3 than the connecting portion 41. The locking portion 42 has a tapered structure that expands towards the guide wing 3, meaning it is not connected to the cuff 1. The locking portion 42 moves towards the guide wing 3 under the influence of the connecting portion 41, thereby fixing the everted blood vessel to the outside of the cuff 1. Specifically, when the blood vessel extends outward to fit the guide wing 3 and partially fits the outer wall of the sleeve 1, multiple guide wing 3 ends can be clamped by a special clamp (such as a round-headed clamp) to slightly contract and deform them towards the center. By rotating the connecting part 41, the connecting part 41 drives the locking part 42 to move towards the guide wing 3. After the locking part 42 covers the outside of the guide wing 3, the clamp is released, and the guide wing 3 is reset and tensioned inside the locking part 42. At the same time, the connecting part 41 can also press the part of the blood vessel that fits the outer wall of the sleeve 1 to the outer wall of the sleeve 1 through the threaded structure, thereby forming a double fixation of the blood vessel.

[0052] The maximum expansion width of the conical structure is less than the maximum distance between the two oppositely arranged guide vanes 3, so that the locking part 42 can tightly press the guide vanes 3 to compress the blood vessel.

[0053] As a preferred implementation, the arc-shaped outward-folding structure of the guide wing 3 forms a conical guide inlet 31 at the end of the sleeve 1. The guide inlet 31 can be used to guide the docked blood vessel to enter quickly, compensating for the problem of reduced inlet size of the sleeve 1 after the guide wing 3 is installed.

[0054] In a preferred embodiment, the length of the guide wing 3 is 0.4mm to 0.6mm, and the distance between the outwardly flared portion of the guide wing 3 and the outer wall of the cuff 1 is 0.15mm to 0.25mm. This ensures that the outward convex height of the guide wing 3 is appropriate, avoiding excessive height (more than 0.25mm) which would make it difficult for the blood vessel to flare out, and avoiding excessive height (less than 0.15mm) which would prevent it from being pressed tightly against the locking part 42.

[0055] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A quick-connect vascular graft structure for organ transplantation in experimental animals, characterized in that, It includes a sleeve tube and a sleeve handle disposed at one end of the sleeve tube. The sleeve tube has a hollow columnar structure. The sleeve handle has an arc-shaped sheet structure with the same curvature as the sleeve tube. One end of the sleeve handle is partially circumferentially connected to one end of the sleeve tube.

2. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 1, characterized in that, The width of the sleeve arm gradually decreases away from the sleeve tube and ends in an arc at the far end of the sleeve arm.

3. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 2, characterized in that, The arc length of the end of the sleeve handle near the sleeve tube is 1 / 4 to 1 / 2 of the circumference of the sleeve tube.

4. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 1, characterized in that, The outer wall of the end of the sleeve tube away from the sleeve handle is provided with external threads.

5. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 4, characterized in that, At least two guide wings are provided at the end of the sleeve tube away from the sleeve handle, and the two guide wings are symmetrically arranged along the radial direction of the sleeve tube; each guide wing is folded outward in an arc shape from the inner wall of the sleeve tube to the outer wall of the sleeve tube and is movably engaged with the outer wall of the sleeve tube; wherein, the guide wings are made of superelastic nickel-titanium alloy.

6. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 5, characterized in that, Four guide vanes are provided, and the four guide vanes are evenly spaced along the circumference of the sleeve tube.

7. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 5 or 6, characterized in that, A locking ring is fitted around the outside of the sleeve tube. The locking ring includes a connecting part and a locking part integrally connected along the axial direction of the sleeve tube. The connecting part is threaded to the outer wall of the sleeve tube. The locking part is close to the guide wing relative to the connecting part. The locking part has a conical structure that expands toward the guide wing. The maximum expansion width of the conical structure is less than the maximum distance between the two oppositely arranged guide wing pieces.

8. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 5 or 6, characterized in that, The guide vane forms a tapered guide inlet at the end of the sleeve to guide the docking blood vessel into place.

9. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 8, characterized in that, The sleeve tube has a length of 2mm to 3mm, and the sleeve arm has a length of 1.5mm to 2.5mm, with the sleeve tube being longer than the sleeve arm.

10. The quick-connect vascular graft structure for experimental animal organ transplantation according to claim 9, characterized in that, The length of the guide wing is 0.4mm to 0.6mm, and the distance between the outwardly folded portion of the guide wing and the outer wall of the sleeve is 0.15mm to 0.25mm.

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