A conductive, low-pollution simulation material for laparoscopic surgery training and its preparation method

Abstract

This application relates to the technical field of biomimetic materials, specifically disclosing a conductive, low-pollution simulation material for laparoscopic surgery training and its preparation method. The conductive, low-pollution simulation material for laparoscopic surgery training comprises the following components in parts by weight: 2.9-3.9 parts hydrophilic colloid; 0.4-0.6 parts leavening agent; 0.05-0.15 parts crosslinking agent; 0.2-0.25 parts N,N,N',N'-tetramethylethylenediamine; and 65 parts water; wherein the hydrophilic colloid is a mixture of gelatin and carrageenan. This conductive, low-pollution simulation material for laparoscopic surgery training can be used in robotic surgery training, replacing traditional materials such as silicone and animal organs. It has the advantages of being conductive, having a softness and hardness close to human tissue, and not causing surgical contamination. Furthermore, the preparation method of this application has the advantages of fewer steps, simplicity, and high efficiency, which is conducive to the industrial-scale production of simulation materials.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological simulation materials, and more particularly to an electrically conductive and low-pollution simulation material for endoscopic surgery training and a preparation method thereof. BACKGROUND

[0002] With the increasing application of surgical robots in the clinic, professional training models required for surgical robot training have become necessary.

[0003] Currently, the models mainly used are divided into the following two types:

[0004] (1) Silicone material, which is characterized by being clean and hygienic and not causing infection, but the silicone material is not conductive and cannot be applied to the training operation of energy instruments of surgical robots;

[0005] (2) Animal organs, which can meet the operation training of conventional instruments and energy instruments, but are greatly polluted by bacteria and germs and cause pollution to surgical robots, resulting in surgical infection in subsequent human surgery.

[0006] Therefore, the silicone material and animal organs used in traditional practical training are not suitable for the requirements of the electrically conductive and low-pollution model used in the current surgical robot training. SUMMARY

[0007] In order to meet the requirements of material conductivity and low pollution and better apply to the surgical robot training process, the present application provides an electrically conductive and low-pollution simulation material for endoscopic surgery training and a preparation method thereof.

[0008] In a first aspect, the present application provides an electrically conductive and low-pollution simulation material for endoscopic surgery training, which adopts the following technical solution:

[0009] An electrically conductive and low-pollution simulation material for endoscopic surgery training comprises the following components by weight:

[0010] 2.9-3.9 parts of a hydrophilic colloid;

[0011] 0.4-0.6 parts of a bulk agent;

[0012] 0.05-0.15 parts of a crosslinking agent;

[0013] 0.2-0.25 parts of N,N,N',N'-tetramethyl ethylenediamine;

[0014] 65 parts of water;

[0015] The hydrophilic colloid is a mixture of gelatin and carrageenan.

[0016] By adopting the technical scheme, the gelatin and carrageenan are used as the base material, so that the simulation material has conductivity, can be applied to the training operation of the energy instrument of the surgical robot, does not carry bacteria, reduces the infection in the human surgery, and the ratio of the gelatin and the carrageenan can control the softness and hardness of the simulation material, and the two different hydrophilic colloids can be compounded according to the need to control the softness and hardness of the simulation model and different human tissues.

[0017] The addition of the bulk agent makes the simulation material have a certain porosity, is close to the density and strength of the human tissue and organ, and can better simulate the impedance and cutting texture of the human organ tissue.

[0018] Optionally, the weight ratio of the gelatin and the carrageenan is 2.2: (0.7-1.7).

[0019] By adopting the technical scheme, with the increase of the amount of the carrageenan, the hardness of the simulation material decreases, and when the weight ratio is in the above range, the simulation material has soft texture and is close to the softness and hardness of the human soft tissue such as lung lobe, liver, kidney and the like.

[0020] Through detection, when the amount of the gelatin and the carrageenan is in the above range, the compression stress of the simulation material under 80% compression strain is 0.3-3.4 MPa, and the simulation material is soft and easy to cut.

[0021] Optionally, the bulk agent is sodium bicarbonate or disodium hydrogen pyrophosphate.

[0022] By adopting the technical scheme, the sodium bicarbonate is added as the bulk agent to form a gap, the porosity of the simulation material is controlled by controlling the amount of the sodium bicarbonate, and the material density and strength are controlled.

[0023] Optionally, the crosslinking agent is ammonium persulfate or N,N'-methylene bisacrylamide.

[0024] By adopting the technical scheme, the above substances can be used as the crosslinking agent in the simulation material, and the effect of the ammonium persulfate is better.

[0025] Optionally, the simulation material further includes the following components in the weight fraction:

[0026] The dissolving agent is 2.0-2.2 parts;

[0027] The bonding agent is 3.5-4.0 parts;

[0028] The antioxidant is 0.04-0.06 parts.

[0029] By adopting the technical scheme, the performance of the simulation material containing the components is better, the dispersion between the components is more uniform, the overall effect is better, and the simulation material is soft and easy to cut.

[0030] Optionally, the dissolving agent is N-isopropyl acrylamide.

[0031] By adopting the technical scheme, the performance of the simulation material containing the components is better, the dispersion between the components is more uniform, the overall effect is better, and the simulation material is soft and easy to cut.

[0032] Optionally, the adhesive is acrylamide or hydroxymethyl cellulose.

[0033] Optionally, the antioxidant is gallic acid or potassium sorbate.

[0034] By adopting the technical scheme, gallic acid and potassium sorbate both have better antioxidant properties and are non-toxic, and will not pollute the simulation material.

[0035] In a second aspect, the application provides a preparation method of an electrically conductive and low-pollution simulation material for endoscopic surgery training, which adopts the following technical scheme:

[0036] A preparation method of an electrically conductive and low-pollution simulation material for endoscopic surgery training, comprising the following steps:

[0037] S1, divide the water into three parts, add the hydrophilic colloid to the first part of water, heat and stir to mix, then add the dissolving agent, the adhesive, and the bulk agent, and mix to obtain a mixed liquid A;

[0038] S2, add the crosslinking agent to the second part of water, and mix to obtain a mixed liquid B;

[0039] S3, add N, N, N', N'-tetramethyl ethylenediamine to the third part of water, and mix to obtain a mixed liquid C;

[0040] S4, blend the mixed liquids A, B, and C, then add the antioxidant, and mix to obtain a hydrogel solution;

[0041] S5, immerse the mold in the hydrogel solution, squeeze the mold to absorb the hydrogel solution, take out the mold, solidify, and demold, and the simulation material is obtained.

[0042] By adopting the technical scheme, the process steps are fewer, simple and efficient, which is conducive to the industrialized scale-up of the simulation material, and the simulation material has a certain porosity, is soft and cuttable, and is electrically conductive and low-pollution, and can be better applied to the training of surgical robots.

[0043] In summary, the application has the following beneficial effects:

[0044] The application uses gelatin and carrageenan as the base material, which endows the material with the conductivity simulating the human body. By adjusting the ratio of the two, the simulation material can be made similar to the hardness of different human tissues, and has low pollution compared with animal organs, which will not cause surgical pollution. By adding a bulk agent, the density of the model is adjusted to be similar to that of human tissues, which can better serve as a training model for surgical robots.

[0045] The application controls the amount of gelatin, carrageenan and bulk agent to make the hardness and density of the simulation material close to human tissues, which is convenient for providing a more realistic simulation of the human body environment for robots.

[0046] 2. The method of the application has fewer process steps, is simple and efficient, is conducive to the industrialized scale-up of the simulation model, and the hardness of the simulation model is similar to that of the human body, which is better for simulation training of surgical robots. DETAILED DESCRIPTION

[0047] The application is further described in detail below in conjunction with examples. In order to meet the requirements of material conductivity and low pollution, the application provides a conductive and low-pollution simulation material for endoscopic surgery training, which comprises the following components in parts by weight: hydrophilic colloid 2.9-3.9 parts; bulk agent 0.4-0.6 parts; crosslinking agent 0.05-0.15 parts; N,N,N',N'-tetramethyl ethylenediamine 0.2-0.25 parts; water 65 parts; the hydrophilic colloid is a mixture of gelatin and carrageenan, and the weight ratio of gelatin to carrageenan is 2.2: (0.7-1.7).

[0048] The application uses gelatin and carrageenan as the base material, which controls the hardness of the material close to human tissues by controlling the ratio of gelatin and carrageenan; a bulk agent is compounded to control the porosity of the material, so that the density and mechanical properties are close to human tissues; in summary, the simulation material is similar to human tissues, which can better simulate the impedance and cutting texture of human organ tissues.

[0049] Among them, the sources of each component are as follows, and others are all commercially available:

[0050] Gelatin is from Shenzhen Lovefu Biological Technology Co., Ltd., model number 20200510;

[0051] Carrageenan is from Shaanxi Ran'ou Biological Technology Co., Ltd., model number 0-39-78;

[0052] N-isopropyl acrylamide is from Shandong Liang New Material Technology Co., Ltd., model number LA6529;

[0053] Gallic acid is from Shaanxi Bolin Biological Technology Co., Ltd., model number BL20220429008;

[0054] The polyurethane foaming glue is obtained from Langfang Chenhao Chemical Building Material Co., Ltd., and is a two-component. Comparative Example 1

[0055] An electrically conductive and low-pollution simulation material for endoscopic surgery training is prepared by the following steps:

[0056] S1, divide the water into three parts, add 2.2 kg of hydrophilic colloid (gelatin) to the first portion of water (45 kg), heat to 55°C and stir for 20 min, then stir for another 3 min to obtain a mixed solution A;

[0057] S2, add 0.1 kg of crosslinking agent (ammonium persulfate) to the second portion of water (10 kg), and mix by conventional stirring to obtain a mixed solution B;

[0058] S3, add 0.22 kg of N,N,N',N'-tetramethyl ethylenediamine to the third portion of water (10 kg), and mix by conventional stirring to obtain a mixed solution C;

[0059] S4, blend the mixed solutions A, B, and C, and stir for 60 min at a speed of 250 rpm to obtain a hydrogel solution;

[0060] S5, immerse the mold in the hydrogel solution, squeeze the mold to absorb the hydrogel solution, and make the hydrogel be fully absorbed into the mold, take out the mold and place it at 25°C for 3 h for solidification, then demold to obtain the product.

[0061] The mold is formed by foaming the mixture of 20 g of component A and 10 g of component B of the polyurethane foaming glue.

[0062] Examples 1-3

[0063] An electrically conductive and low-pollution simulation material for endoscopic surgery training is prepared by the following steps:

[0064] S1, divide the water into three parts, add hydrophilic colloid (gelatin, carrageenan) to the first portion of water (45 kg), heat to 55°C and stir for 20 min, then add a dissolving agent (N-isopropyl acrylamide) and a binder (acrylamide), and stir for 3 min to obtain a mixed solution A;

[0065] S2, add a crosslinking agent (ammonium persulfate) to the second portion of water (10 kg), and mix by conventional stirring to obtain a mixed solution B;

[0066] S3, add N,N,N',N'-tetramethyl ethylenediamine to the third portion of water (10 kg), and mix by conventional stirring to obtain a mixed solution C;

[0067] S4, blending the mixed solutions A, B and C, adding antioxidant (gallic acid), stirring at 250 rpm for 60 min, and obtaining a hydrogel solution;

[0068] S5, immersing the mold into the hydrogel solution, extruding the mold to absorb the hydrogel solution, and taking out the mold and placing it at 25℃ for 3h to solidify, demolding, and obtaining the product.

[0069] The mold was formed by foaming 20g of component A and 10g of component B of polyurethane foaming glue.

[0070] Table 1: Components and their weights (kg) in Examples 1-3

[0071]

[0072] Performance test

[0073] The simulation material prepared in the examples and comparative examples was used to prepare a sample according to GB / T 528-2009, and the compression stress under different compression strains was detected.

[0074] The sample was installed on a test bench, a multifunctional tensile and compression machine was used to apply pressure to make the sample produce pressure deformation, and the force and the strain value of the sample were monitored, and the compression stress when the sample produced 80%, 90% and 100% compression deformation was recorded, and the detection results were recorded in Table 2.

[0075] Table 2: Performance test results

[0076]

[0077] Comparing Examples 1-3 and Comparative Example 1:

[0078] In Examples 2-3, the ratio of gelatin to carrageenan was controlled, and the porosity of the material was controlled by adding a bulk agent, so that the compression stress of the prepared material was small when the material was compressed, indicating that the texture was soft and easy to cut.

[0079] In the preparation process of the simulation material of Comparative Example 1, no carrageenan and sodium bicarbonate (bulk agent) were added, and the compression stress of the prepared material was significantly improved, which was too different from human tissue, and was not suitable for surgical robot training.

[0080] The specific embodiments are merely an explanation of the present application, and are not a limitation of the present application, and those skilled in the art can make modifications to the embodiments without creative contribution after reading the present specification, but as long as the modifications are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. An electrically conductive, low-polluting simulation material for endoscopic surgery training, characterized in that, The raw material comprises components in the following weight proportions: hydrophilic colloid 2.9-3.9 parts; sodium bicarbonate 0.4-0.6 parts; ammonium persulfate 0.05-0.15 parts; N,N,N',N'-tetramethyl ethylenediamine 0.2-0.25 parts; water 65 parts; N-isopropyl acrylamide 2.0-2.2 parts; acrylamide 3.5-4.0 parts; antioxidant 0.04-0.06 parts; the hydrophilic colloid is a mixture of gelatin and carrageenan; the weight ratio of the gelatin to the carrageenan is 2.2: (1.1-1.7).

2. The electrically conductive, low-polluting simulation material for endoscopic surgery training according to claim 1, characterized in that, The antioxidant is gallic acid or potassium sorbate.

3. A process for the preparation of the electrically conductive, low-fouling artificial material according to any one of claims 1-2, characterized in that, The method comprises the following steps: S1, divide the water into three portions, add the hydrophilic colloid to the first portion of water, mix and stir under heating, then add N-isopropyl acrylamide, acrylamide and sodium bicarbonate to obtain a mixed solution A; S2, add ammonium persulfate to the second portion of water to obtain a mixed solution B; S3, add N,N,N',N'-tetramethyl ethylenediamine to the third portion of water to obtain a mixed solution C; S4, mix the mixed solutions A, B and C, then add the antioxidant to obtain a hydrogel solution; S5, immerse a mold into the hydrogel solution, squeeze the mold to absorb the hydrogel solution, take out the mold, solidify, demold, and obtain the product.

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