A pediatric growth promoting formulation

Abstract

The application discloses a kind of pediatric growth promoting preparation, belong to the technical field of traditional Chinese medicine preparation, including Fructus Schisandrae, radix pseudoginseng, dried ginger, angelica, amomum villosum, incense, dried tangerine or orange peel, June snow, Chir Chir, dog spine, and cow bone powder.The preparation of the present application combines the theory of traditional Chinese medicine for invigorating the spleen and kidney, regulating qi and blood, wherein Fructus Schisandrae, radix pseudoginseng, dried ginger and the like can invigorate the spleen and stimulate appetite, significantly improve the digestive function and improve the absorption rate of nutritional substances;Amomum villosum and amomum villosum regulate the middle-jiao qi movement, relieve abdominal distension and stagnation of qi, and further optimize the absorption state;Chir Chir, dog spine and cow bone powder directly act on the skeletal system, tonify the kidney and strengthen the bone, promote chondrocyte proliferation and longitudinal growth of the skeleton, and effectively improve the height growth speed.The formula takes into account the intervention of growth disorders such as precocious puberty, delays the bone age through the bidirectional regulation of nourishing yin and purging fire and tonifying the kidney and filling essence, and gains valuable time for height growth.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a pediatric growth-promoting preparation. Background Technology

[0002] Height is a major concern for parents during children's growth and development. Many factors influence a child's height, including genetics, nutrition, sleep, exercise, and endocrine function. Short stature refers to a child's height being two standard deviations below the average height of children of the same race, sex, and age, living in similar environments. Puberty is a crucial period in a child's growth and development, characterized by the appearance of secondary sexual characteristics and a growth spurt. The growth spurt, or accelerated longitudinal growth, is the result of the coordinated action of the hypothalamic-pituitary-gonadal axis and the hypothalamic-pituitary-growth axis.

[0003] Precocious puberty is caused by the premature activation and hyperfunction of the hypothalamic-pituitary-gonadal axis. The order of the appearance of sexual characteristics is the same as that of normal puberty, but the appearance of sexual characteristics is too early and the time limit is shortened. Therefore, it often causes advanced bone age and premature fusion of the epiphyses, which ultimately leads to short stature in adulthood, even less than 150cm.

[0004] Traditional Chinese medicine believes that precocious puberty is caused by kidney yin deficiency and excessive fire. Early use of yin-nourishing and fire-clearing Chinese medicine can significantly improve puberty sexual characteristics, shrink the uterus and ovaries, and reduce breast buds. At the same time, it can delay further bone age advancement and buy time for bone growth. When the child reaches puberty age, the use of kidney-tonifying and essence-replenishing Chinese medicine can reactivate the hypothalamus-pituitary-gonadal axis, causing the uterus and ovaries to enlarge, the breast buds to enlarge, and accelerate bone growth.

[0005] Traditional Chinese medicine patches are applied to specific acupoints in different types to tonify the spleen and kidneys, thereby promoting children's growth. By stimulating acupoints such as Yongquan (KI1), Pishu (BL20), Shenque (CV8), and Zusanli (ST36), they can replenish qi, strengthen the spleen and stomach, improve appetite, meet nutritional needs, and promote height growth.

[0006] Conventional treatment with growth hormone is complicated by the complex causes of the disease, with vastly different treatment effects depending on the cause. It is also expensive, requires subcutaneous injection, has a long treatment time, poor compliance, and certain adverse reactions such as nausea, vomiting, dizziness, palpitations, and allergies, accounting for a relatively high proportion of about 16%.

[0007] This invention provides a pediatric growth-promoting preparation, composed of traditional Chinese medicine and natural ingredients, which can be used to make acupoint plasters, conventional ointments, capsules, and oils, improving safety, convenience, and economy. Experiments have confirmed its real therapeutic effect. Summary of the Invention

[0008] Therefore, the present invention provides a pediatric growth-promoting preparation to solve the technical problems existing in the prior art.

[0009] To achieve the above objectives, the present invention provides the following technical solution:

[0010] According to a first aspect of the present invention, a pediatric growth-promoting preparation is provided, comprising the following components in parts by weight:

[0011] 3-10 servings of Alpinia oxyphylla

[0012] 2-10 portions of Codonopsis pilosula

[0013] 3-9 parts dried ginger

[0014] 2-8 servings of hawthorn

[0015] Angelica sinensis 3-10 parts

[0016] 2-10 portions of Amomum villosum

[0017] 2-10 parts of Tibetan incense

[0018] 3-12 portions of dried tangerine peel

[0019] June Snow 2-6 portions

[0020] 2-8 portions of bamboo joint ginseng

[0021] 2-8 parts of Cibotium barometz

[0022] 1-10 parts beef bone meal

[0023] Scrophularia ningpoensis 3-10 parts.

[0024] Furthermore, it includes the following components in parts by weight:

[0025] 4-7 portions of Alpinia oxyphylla

[0026] 2-5 portions of Codonopsis pilosula

[0027] 3-7 parts dried ginger

[0028] 3-6 servings of hawthorn

[0029] Angelica sinensis 4-7 parts

[0030] 2-5 parts of Amomum villosum

[0031] 2-6 parts of Tibetan incense

[0032] 4-10 portions of dried tangerine peel

[0033] June Snow 2-5 portions

[0034] 3-6 portions of bamboo joint ginseng

[0035] 2-5 portions of Cibotium barometz

[0036] 3-6 parts beef bone meal

[0037] Scrophularia ningpoensis 4-10 parts.

[0038] Furthermore, it includes the following components in parts by weight:

[0039] 5 portions of Alpinia oxyphylla

[0040] 3 portions of Codonopsis pilosula

[0041] 5 parts dried ginger

[0042] 5 portions of hawthorn

[0043] 5 parts Angelica sinensis

[0044] 3 parts of cardamom

[0045] 3 portions of Tibetan incense

[0046] 6 portions of dried tangerine peel

[0047] 5 portions of June Snow

[0048] 5 portions of bamboo joint ginseng

[0049] 5 portions of Cibotium barometz

[0050] 5 portions of beef bone meal

[0051] Six parts of Scrophularia ningpoensis.

[0052] The effects of the above-mentioned ingredients are as follows:

[0053] Alpinia oxyphylla, the fruit of the ginger family plant Alpinia oxyphylla, has the effects of warming the spleen to stop diarrhea and reduce salivation, warming the kidneys to reduce urination and consolidate essence. It is often used for spleen and stomach deficiency and cold, vomiting, diarrhea, abdominal cold pain, excessive salivation, kidney deficiency with enuresis, frequent urination, seminal emission, and leukorrhea. It also regulates sleep quality, promotes deep sleep, and promotes growth hormone secretion.

[0054] Codonopsis pilosula is a perennial herb belonging to the genus Codonopsis in the family Caryophyllaceae. It has the effects of invigorating qi and strengthening the spleen, promoting body fluid production and moistening the lungs. It is used for spleen deficiency and fatigue, loss of appetite, weakness after illness, qi and yin deficiency, spontaneous sweating and thirst, and dry cough due to lung dryness. It provides essential nutrients for growth, regulates immunity, and promotes bone development.

[0055] Dried ginger can relieve vomiting, stomach pain, and diarrhea, protect the gastric mucosa to reduce the risk of ulcers, and alleviate inflammation. It can promote gastrointestinal motility to aid digestion, improve bloating, and also regulate blood pressure and relieve pain. Furthermore, it can help lower blood lipids, protect liver and gallbladder function, improve hypoxia tolerance, and help improve sleep quality. It also stimulates the secretion of digestive juices and improves nutrient absorption.

[0056] Angelica sinensis can help generate more blood, improving cold hands and feet and pale complexion; it can regulate the menstrual cycle, relieve dysmenorrhea and abdominal pain during menstruation; it can promote intestinal peristalsis and improve constipation. Modern research has found that it can enhance immunity, protect the cardiovascular system, and prevent blood vessel blockage; it can relieve uterine spasms and enhance contractions, help regulate blood pressure and blood lipid levels, and also has the effects of relieving pain, protecting the liver, and inhibiting bacterial growth. It regulates hormones, enhances metabolism and stress resistance, nourishes and invigorates blood, and promotes growth.

[0057] Amomum villosum is commonly used to improve problems such as bloating, poor appetite, and diarrhea. It promotes digestion, relieves abdominal distension, and alleviates stomach pain and diarrhea caused by cold. Modern research has also found that it can reduce inflammatory pain and help control blood sugar. It relieves abdominal distension, promotes intestinal peristalsis, strengthens the spleen and stomach, and improves digestion.

[0058] Tibetan costus root belongs to the Asteraceae family. Its root is used medicinally; it has a pungent and bitter taste and is warm in nature. Its main functions include strengthening the spleen and stomach, regulating qi and relieving depression, relieving pain, and calming the fetus. It is used for chronic gastritis, gastrointestinal dysfunction, intercostal neuralgia, chest wall contusions, and muscle aches. In addition, Tibetan medicine also uses it to clear blood heat and dispel wind; it treats wind-heat syndrome and blood-heat syndrome.

[0059] Dried tangerine peel has the effect of strengthening the spleen and improving appetite. It contains a special aroma that can improve appetite, promote the secretion of digestive juices, enhance intestinal function, and relieve symptoms such as abdominal distension, loss of appetite, and vomiting and diarrhea. Secondly, dried tangerine peel has the effect of drying dampness and resolving phlegm, which can remove dampness from the body and promote the expulsion of phlegm, thus providing some relief for symptoms of cough with excessive phlegm.

[0060] The medicinal properties of *Serissa japonica* include clearing heat and detoxifying, cooling the blood and stopping bleeding. *Serissa japonica* has the effect of clearing heat and detoxifying, and can be used to treat dysentery, cough, sore throat, red and swollen eyes, carbuncles, and snake bites. The herb *Serissa japonica* also has the effect of cooling the blood and stopping bleeding, and can treat symptoms such as bitter taste in the mouth, hypochondriac pain, irritability, and anger caused by liver fire.

[0061] The rhizome of *Panax japonicus* is used medicinally. It mainly contains saponins, primarily *Panax japonicus* saponin III; these components have anti-inflammatory, anti-aging, and blood sugar-lowering effects. It is sweet, slightly bitter, and warm in nature; it nourishes and strengthens the body, disperses blood stasis and relieves pain, stops bleeding and eliminates phlegm; it is used for post-illness weakness, tuberculosis with hemoptysis, cough with excessive phlegm, traumatic injuries, and promotes cartilage growth.

[0062] The main benefits of Cibotium barometz include improving joint pain, enhancing bone health, promoting blood circulation, relieving muscle fatigue, and assisting in the treatment of osteoporosis. It also nourishes the kidneys, strengthens bones, and promotes bone development.

[0063] Beef bone powder is a nutritional supplement made from beef bones, primarily containing calcium, collagen, amino acids, and minerals. Its core benefits include strengthening bones through calcium absorption, improving joint health, promoting wound healing, and boosting immunity. It is suitable for people in the bone development stage and those recovering from surgery.

[0064] Scrophularia has the effects of nourishing yin and purging fire, clearing heat and cooling blood, and detoxifying and dispersing nodules.

[0065] According to a second aspect of the present invention, a method for preparing a pediatric growth-promoting agent is provided, comprising the following processing steps:

[0066] Weigh out the following ingredients according to the specified proportions: Alpinia oxyphylla, Codonopsis pilosula, dried ginger, hawthorn, Angelica sinensis, Amomum villosum, Aucklandia lappa, dried tangerine peel, Serissa japonica, Panax japonicus, Cibotium barometz, Scrophularia ningpoensis, and ox bone powder. Grind them to a particle size of 200 mesh and set aside.

[0067] Take Alpinia oxyphylla, Codonopsis pilosula, dried ginger, hawthorn, Angelica sinensis, Amomum villosum, Aucklandia lappa, tangerine peel, Serissa japonica, Panax japonicus, Cibotium barometz and Scrophularia ningpoensis, soak them in 70% ethanol aqueous solution, concentrate under reduced pressure, dry under reduced pressure into powder, mix with bovine bone powder, add while stirring until evenly mixed to obtain a pediatric growth-promoting preparation.

[0068] According to a third aspect of the present invention, the method for preparing pediatric growth-promoting agents is used in the preparation of pediatric growth-promoting patches, ointments, oils, or capsules.

[0069] Furthermore, the production of pediatric growth-promoting patches also includes the following steps:

[0070] The silicone, rubber, or hot melt adhesive matrix is ​​heated and melted. The melting temperature is determined according to the selection of materials. Pediatric growth promoters are added while stirring until they are completely mixed to obtain a mixture.

[0071] Add the mixture into the mold, let it cool and set, and set aside.

[0072] Furthermore, the production of ointments also includes the following steps:

[0073] Add the pediatric growth promoter to deionized water according to the specified ratio and soak for 6-12 hours. Filter to obtain the filtrate for later use; preferably, add according to a solid-liquid ratio of 1:10.

[0074] The filtrate is heated and evaporated, concentrated to 1 / 10 of its original volume, and then a suitable amount of hardening agent is added and mixed thoroughly to obtain a paste. Preferably, the heating temperature is controlled at 40-80℃.

[0075] Furthermore, the production of oils also includes the following steps:

[0076] The pediatric growth-promoting agent is added to vegetable oil in a certain proportion and heated and soaked for 2-4 hours. After filtration, the filtrate is concentrated to obtain the oil. Preferably, it is added at a solid-liquid ratio of 1:4.

[0077] Furthermore, the production of capsules also includes the following steps:

[0078] The pediatric growth promoter is mixed with an adhesive to form uniform granules, which are then filled into capsule shells to obtain capsules.

[0079] The present invention has the following advantages:

[0080] This application uses pure traditional Chinese medicine ingredients as raw materials, promoting children's growth and development through the synergistic effect of multiple components. The formulation integrates the TCM theories of "strengthening the spleen and kidneys" and "harmonizing qi and blood." In particular, ingredients such as Alpinia oxyphylla, Codonopsis pilosula, and dried ginger strengthen the spleen and improve digestion, significantly increasing nutrient absorption. Inula japonica and Amomum villosum regulate the qi of the middle jiao, relieving abdominal distension and further optimizing absorption. Serissa japonica clears heat and detoxifies, eliminating damp-heat and inflammatory factors from the body, creating a stable internal environment. Meanwhile, Codonopsis pilosula, Cibotium barometz, and bovine bone powder directly act on the skeletal system, tonifying the kidneys and strengthening bones, promoting chondrocyte proliferation and longitudinal bone growth, effectively increasing height growth rate. Simultaneously, this application optimizes the ratio of Inula japonica, Serissa japonica, and Codonopsis pilosula, with the formula also addressing growth disorders such as precocious puberty. Through the dual regulation of nourishing yin and clearing heat while tonifying the kidneys and replenishing essence, it delays advanced bone age, buying valuable time for height growth. Attached Figure Description

[0081] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0082] The structures, proportions, sizes, etc. illustrated in this specification are only for the purpose of assisting those skilled in the art in understanding and reading the content disclosed herein, and are not intended to limit the conditions under which the present invention can be implemented. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportions, or adjustments to the size, without affecting the effects and objectives that the present invention can produce, should still fall within the scope of the technical content disclosed in the present invention.

[0083] Figure 1 This is a schematic diagram of the pressure dressing provided in Embodiments 1-5 of the present invention. Detailed Implementation

[0084] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0085] According to a first aspect of the present invention, a pediatric growth-promoting preparation is provided, comprising the following components in parts by weight:

[0086] 3-10 servings of Alpinia oxyphylla

[0087] 2-10 portions of Codonopsis pilosula

[0088] 3-9 parts dried ginger

[0089] 2-8 servings of hawthorn

[0090] Angelica sinensis 3-10 parts

[0091] 2-10 portions of Amomum villosum

[0092] 2-10 parts of Tibetan incense

[0093] 3-12 portions of dried tangerine peel

[0094] June Snow 2-6 portions

[0095] 2-8 portions of bamboo joint ginseng

[0096] 2-8 parts of Cibotium barometz

[0097] 1-10 parts beef bone meal

[0098] Scrophularia ningpoensis 3-10 parts.

[0099] According to a second aspect of the present invention, a method for preparing a pediatric growth-promoting agent is provided, comprising the following processing steps:

[0100] Weigh out the following ingredients according to the specified proportions: Alpinia oxyphylla, Codonopsis pilosula, dried ginger, hawthorn, Angelica sinensis, Amomum villosum, Aucklandia lappa, dried tangerine peel, Serissa japonica, Panax japonicus, Cibotium barometz, Scrophularia ningpoensis, and ox bone powder. Grind them to a particle size of 200 mesh and set aside.

[0101] The following ingredients were soaked in a 70% ethanol aqueous solution, followed by vacuum concentration: Alpinia oxyphylla, Codonopsis pilosula, dried ginger, hawthorn, Angelica sinensis, Amomum villosum, Aucklandia lappa, Citrus reticulata peel, Serissa japonica, Panax japonicus, Cibotium barometz, and Scrophularia ningpoensis. The mixture was then dried under reduced pressure and mixed into powder. The powder was then mixed with bovine bone powder while stirring until it was evenly mixed to obtain a pediatric growth-promoting preparation.

[0102] According to a third aspect of the present invention, the method for preparing pediatric growth-promoting agents is used in the preparation of pediatric growth-promoting patches, ointments, oils, or capsules.

[0103] Furthermore, the production of pediatric growth-promoting patches also includes the following steps:

[0104] The silicone, rubber, or hot melt adhesive matrix is ​​heated and melted. The melting temperature is determined according to the selection of materials. Pediatric growth promoters are added while stirring until they are completely mixed to obtain a mixture.

[0105] Add the mixture into the mold, let it cool and set, and set aside.

[0106] Furthermore, the production of ointments also includes the following steps:

[0107] Add the pediatric growth promoter to deionized water according to the specified ratio and soak for 6-12 hours. Filter to obtain the filtrate for later use; preferably, add according to a solid-liquid ratio of 1:10.

[0108] The filtrate is heated and evaporated, concentrated to 1 / 10 of its original volume, and then a suitable amount of hardening agent is added and mixed thoroughly to obtain a paste. Preferably, the heating temperature is controlled at 40-80℃.

[0109] Furthermore, the production of oils also includes the following steps:

[0110] The pediatric growth-promoting agent is added to vegetable oil in a certain proportion and heated and soaked for 2-4 hours. After filtration, the filtrate is concentrated to obtain the oil. Preferably, it is added at a solid-liquid ratio of 1:4.

[0111] Furthermore, the production of capsules also includes the following steps:

[0112] The pediatric growth promoter is mixed with an adhesive to form uniform granules, which are then filled into capsule shells to obtain capsules.

[0113] The technical effects of the present invention will be described below with reference to specific embodiments.

[0114] Example 1

[0115] This embodiment provides a method for preparing a pediatric growth-promoting agent, and the processing steps are as follows:

[0116] Weigh out 40g of Alpinia oxyphylla, 20g of Codonopsis pilosula, 30g of dried ginger, 30g of hawthorn, 40g of Angelica sinensis, 20g of Amomum villosum, 20g of Aucklandia lappa, 40g of dried tangerine peel, 20g of Serissa japonica, 30g of Panax japonicus, 20g of Cibotium barometz, 20g of Scrophularia ningpoensis, and 30g of ox bone powder according to the specified proportions, and grind them to a particle size of 200 mesh for later use.

[0117] Take Alpinia oxyphylla, Codonopsis pilosula, dried ginger, hawthorn, Angelica sinensis, Amomum villosum, Aucklandia lappa, tangerine peel, Serissa japonica, Panax japonicus, Cibotium barometz and Scrophularia ningpoensis, soak them in 70% ethanol aqueous solution, concentrate under reduced pressure, dry under reduced pressure into powder, mix with bovine bone powder, add while stirring until evenly mixed to obtain a pediatric growth-promoting preparation.

[0118] The preparation of the pediatric growth-promoting patch is as follows:

[0119] Heat the hot melt adhesive to about 200℃ to melt it, and add the pediatric growth promoter at a weight ratio of 1:10 of hot melt adhesive to pediatric growth promoter while stirring until it is completely mixed to obtain the mixture.

[0120] The mixture is added to a mold and cooled to set, forming a ring-shaped fixing piece 2 with a pressure body 3 at its center. This is then used to further prepare a pressure dressing, such as... Figure 1 As shown, the specific structure is as follows:

[0121] A pressure dressing includes an adhesive layer 1, an annular fixing piece 2 on the adhesive surface of the adhesive layer 1, and a pressure body 3 at the center of the annular fixing piece. In use, the dressing is attached to the child's body through the adhesive layer 2, and the pressure body 3 applies medicated pressure to acupoints.

[0122] Example 2

[0123] This embodiment provides a method for preparing a pediatric growth-promoting agent, and the processing steps are as follows:

[0124] Weigh out 70g of Alpinia oxyphylla, 50g of Codonopsis pilosula, 70g of dried ginger, 60g of hawthorn, 70g of Angelica sinensis, 50g of Amomum villosum, 60g of Aucklandia lappa, 100g of dried tangerine peel, 50g of Serissa japonica, 60g of Panax japonicus, 50g of Cibotium barometz, 60g of Scrophularia ningpoensis, and 60g of ox bone powder according to the specified proportions, and grind them to a particle size of 200 mesh for later use.

[0125] The following ingredients were soaked in a 70% ethanol aqueous solution, concentrated under reduced pressure, dried under reduced pressure and dried into powder. They were then mixed with bovine bone powder while stirring until they were evenly mixed to obtain a pediatric growth-promoting preparation.

[0126] The preparation of the pediatric growth-promoting patch is as follows:

[0127] Heat the hot melt adhesive to about 200℃ to melt it, and add the pediatric growth promoter at a weight ratio of 1:10 of hot melt adhesive to pediatric growth promoter while stirring until it is completely mixed to obtain the mixture.

[0128] The mixture is added to a mold and cooled to set, forming a ring-shaped fixing piece 2 with a pressure body 3 at its center. This is then used to further prepare a pressure dressing, such as... Figure 1 As shown, the specific structure is as follows:

[0129] A pressure dressing includes an adhesive layer 1, an annular fixing piece 2 on the adhesive surface of the adhesive layer 1, and a pressure body 3 at the center of the annular fixing piece. In use, the dressing is attached to the child's body through the adhesive layer 2, and the pressure body 3 applies medicated pressure to acupoints.

[0130] Example 3

[0131] This embodiment provides a method for preparing a pediatric growth-promoting agent, and the processing steps are as follows:

[0132] Weigh out 50g of Alpinia oxyphylla, 30g of Codonopsis pilosula, 50g of dried ginger, 50g of hawthorn, 50g of Angelica sinensis, 30g of Amomum villosum, 30g of Aucklandia lappa, 60g of dried tangerine peel, 50g of Serissa japonica, 50g of Panax japonicus, 50g of Cibotium barometz, 60g of Scrophularia ningpoensis, and 50g of ox bone powder according to the specified proportions, and grind them to a particle size of 200 mesh for later use.

[0133] The following ingredients were soaked in a 70% ethanol aqueous solution, concentrated under reduced pressure, dried under reduced pressure and dried into powder. They were then mixed with bovine bone powder while stirring until they were evenly mixed to obtain a pediatric growth-promoting preparation.

[0134] The preparation of the pediatric growth-promoting patch is as follows:

[0135] Heat the hot melt adhesive to about 200℃ to melt it, and add the pediatric growth promoter at a weight ratio of 1:10 of hot melt adhesive to pediatric growth promoter while stirring until it is completely mixed to obtain the mixture.

[0136] The mixture is added to a mold and cooled to set, forming a ring-shaped fixing piece 2 with a pressure body 3 at its center. This is then used to further prepare a pressure dressing, such as... Figure 1 As shown, the specific structure is as follows:

[0137] A pressure dressing includes an adhesive layer 1, an annular fixing piece 2 on the adhesive surface of the adhesive layer 1, and a pressure body 3 at the center of the annular fixing piece. In use, the dressing is attached to the child's body through the adhesive layer 2, and the pressure body 3 applies medicated pressure to acupoints.

[0138] Example 4

[0139] This embodiment provides a method for preparing a pediatric growth-promoting agent, and the processing steps are as follows:

[0140] Weigh out 55g of Alpinia oxyphylla, 35g of Codonopsis pilosula, 50g of dried ginger, 45g of hawthorn, 55g of Angelica sinensis, 35g of Amomum villosum, 40g of Aucklandia lappa, 70g of dried tangerine peel, 35g of Serissa japonica, 45g of Panax japonicus, 35g of Cibotium barometz, 50g of Scrophularia ningpoensis, and 45g of ox bone powder according to the specified proportions, and grind them to a particle size of 200 mesh for later use.

[0141] The following ingredients were soaked in a 70% ethanol aqueous solution, concentrated under reduced pressure, dried under reduced pressure and dried into powder. They were then mixed with bovine bone powder while stirring until they were evenly mixed to obtain a pediatric growth-promoting preparation.

[0142] The preparation of the pediatric growth-promoting patch is as follows:

[0143] Heat the hot melt adhesive to about 200℃ to melt it, and add the pediatric growth promoter at a weight ratio of 1:10 of hot melt adhesive to pediatric growth promoter while stirring until it is completely mixed to obtain the mixture.

[0144] The mixture is added to a mold and cooled to set, forming a ring-shaped fixing piece 2 with a pressure body 3 at its center. This is then used to further prepare a pressure dressing, such as... Figure 1 As shown, the specific structure is as follows:

[0145] A pressure dressing includes an adhesive layer 1, an annular fixing piece 2 on the adhesive surface of the adhesive layer 1, and a pressure body 3 at the center of the annular fixing piece. In use, the dressing is attached to the child's body through the adhesive layer 2, and the pressure body 3 applies medicated pressure to acupoints.

[0146] Example 5

[0147] This embodiment provides a method for preparing a pediatric growth-promoting agent, and the processing steps are as follows:

[0148] Weigh out 60g of Alpinia oxyphylla, 40g of Codonopsis pilosula, 60g of dried ginger, 50g of hawthorn, 60g of Angelica sinensis, 40g of Amomum villosum, 50g of Aucklandia lappa, 80g of dried tangerine peel, 40g of Serissa japonica, 50g of Panax japonicus, 40g of Cibotium barometz, 50g of Scrophularia ningpoensis, and 50g of ox bone powder according to the specified proportions, and grind them to a particle size of 200 mesh for later use.

[0149] The following ingredients were soaked in a 70% ethanol aqueous solution, concentrated under reduced pressure, dried under reduced pressure and dried into powder. They were then mixed with bovine bone powder while stirring until they were evenly mixed to obtain a pediatric growth-promoting preparation.

[0150] The preparation of the pediatric growth-promoting patch is as follows:

[0151] Heat the hot melt adhesive to about 200℃ to melt it, and add the pediatric growth promoter at a weight ratio of 1:10 of hot melt adhesive to pediatric growth promoter while stirring until it is completely mixed to obtain the mixture.

[0152] The mixture is added to a mold and cooled to set, forming a ring-shaped fixing piece 2 with a pressure body 3 at its center. This is then used to further prepare a pressure dressing, such as... Figure 1 As shown, the specific structure is as follows:

[0153] A pressure dressing includes an adhesive layer 1, an annular fixing piece 2 on the adhesive surface of the adhesive layer 1, and a pressure body 3 at the center of the annular fixing piece. In use, the dressing is attached to the child's body through the adhesive layer 2, and the pressure body 3 applies medicated pressure to acupoints.

[0154] Comparative Example 1

[0155] Comparative Example 1 is based on Example 3, without the addition of Tibetan incense.

[0156] Comparative Example 2

[0157] Comparative Example 1 is based on Example 3, but without the addition of Serissa japonica.

[0158] Comparative Example 3

[0159] Comparative Example 1 is based on Example 3, without the addition of Tibetan incense and Serissa japonica.

[0160] Comparative Example 4

[0161] Comparative Example 1 is based on Example 3, without the addition of bamboo joint ginseng.

[0162] Comparative Example 5

[0163] Comparative Example 1 is based on Example 3, without the addition of Tibetan incense, Serissa japonica, and Codonopsis pilosula.

[0164] Blank comparison example

[0165] In this blank control example, no pediatric growth-promoting agents were added to prepare the pressure dressing.

[0166] Test Example 1

[0167] Twenty-one-day-old SD rats were selected and randomly divided into nine groups of ten rats each: Example 1, Example 2, Example 3, Example 4, Example 5, Comparative Example 1, Comparative Example 2, Comparative Example 3, and a blank control group. This stage of growth and development is vigorous and sensitive to growth-promoting factors, making it a commonly used model for evaluating growth-promoting effects.

[0168] Treatment: Shave the back of the rat to create a 4x4cm area. 2 The experimental area is 3x3cm in size, and the experiment is conducted at a fixed time each day. 2 The patch was applied to the experimental area on the back and pressed in place. The patch was replaced every 24 hours. After 28 days of continuous administration, the rats' growth data were measured. The test data are described below:

[0169] 1. Weight measurement: At the beginning of the experiment, the weight of the rats was measured, and again after the experiment. The weight was accurate to 0.1g. The total growth over 28 days was calculated to reflect the overall growth and development status.

[0170] 2. Body length measurement: At the beginning of the experiment, the body length of the rats was measured using a standard animal body length measuring ruler, and measured again after the experiment. The body length was accurate to 0.1 cm, and the total growth over 28 days was calculated to reflect the longitudinal growth of the skeleton.

[0171] 3. Measurement of IGF-1 levels: At the end of the experiment, after anesthetizing the rats, blood was collected from the abdominal aorta, centrifuged to obtain serum, and the serum IGF-1 concentration was detected using an enzyme-linked immunosorbent assay (ELISA) kit purchased from Shanghai Boson Biotechnology Co., Ltd., which reflects the activity level of the growth axis.

[0172] 4. Measurement of GH baseline levels: Blood was collected and serum was separated as above. Serum GH concentration was detected using an ELISA kit purchased from Wuhan Pure Biotechnology Co., Ltd., which reflects the state of pituitary GH secretion.

[0173] 5. Tibial bone mineral density and calcium content measurement: After the experiment, the animals were euthanized, the right tibia was dissected, and soft tissue was removed. Tibial metaphysis bone mineral density was measured using dual-energy X-ray absorptiometry (DXA). The bone samples were then ashed, and bone calcium content was determined using atomic absorption spectrometry to assess the degree of bone mineralization and strength, reflecting the extent of bone growth and development.

[0174] The growth and development data of rats in each group after 28 days are shown in Table 1 below:

[0175] Group Weight gain (g) Height increase (cm) Serum IGF-1 (ng / mL) Serum GH (ng / mL) <![CDATA[Tibial BMD (mg / cm 2 )]]> Tibial calcium content (mg / g) Example 1 Group 85.2 5.8 352 5.8 125 185 Example 2 group 87.6 6.1 368 6.0 128 190 Example 3 Group 89.5 6.3 378 6.2 132 195 Example 4 group 88.1 6.2 370 6.1 130 192 Example 5 group 87.8 6.1 365 6.0 129 190 Comparative Example 1 80.3 5.5 330 5.5 120 175 Comparative Example 2 81.0 5.6 335 5.6 122 178 Comparative Example 3 Groups 76.8 5.2 315 5.2 115 170 Comparative Example 4 Groups 78.5 5.3 320 5.3 118 172 Comparative Example 5 Groups 72.4 4.8 295 4.9 110 160 Blank control group 70.1 4.6 285 4.7 105 155

[0176] Based on the above test data, the analysis is as follows:

[0177] 1. Analysis of the effects of Tibetan costus root

[0178] Tibetan costus root has the effects of strengthening the spleen and stomach, regulating qi and relieving depression, and can improve gastrointestinal dysfunction and promote nutrient absorption. In comparison, Group 1 showed lower weight gain, height growth, IGF-1, GH, bone density, and bone calcium content than Group 3 in Example 2. This indicates that Tibetan costus root promotes growth and development by regulating the qi of the middle jiao (middle burner), enhancing the spleen and stomach's digestive function, and promoting the absorption and utilization of nutrients.

[0179] 2. Analysis of the effects of Serissa japonica

[0180] Serissa japonica has the effects of clearing heat and detoxifying, cooling blood and stopping bleeding. It can remove damp heat and inflammatory factors in the body, providing a good internal environment for growth. Among them, the various test indicators of Comparative Group 2 were also lower than those of Example Group 3, especially the IGF-1 and bone mineral density indicators, which decreased significantly. This indicates that Serissa japonica may reduce the inhibition of growth by inflammation in the body and promote the function of the growth hormone axis through anti-inflammatory and immune-regulating functions.

[0181] 3. Analysis of the effects of bamboo joint ginseng

[0182] Bamboo rhizome can nourish and strengthen the body, dispel blood stasis and relieve pain, promote cartilage growth, and directly affect bone development. Among the control groups, the four groups showed the most significant decreases in bone mineral density and bone calcium content, indicating that bamboo rhizome has a direct promoting effect on bone mineralization and longitudinal growth. Simultaneously, IGF-1 and GH levels also decreased, suggesting that bamboo rhizome may indirectly promote growth by regulating growth factor secretion.

[0183] 4. The synergistic effect of the three

[0184] The data from comparative examples 3 and 5 were significantly lower than those from the single missing group (comparative examples 1, 2, and 4), indicating that the three herbs have a synergistic effect in the formula. Tibetan costus root optimizes digestion and absorption, June snow clears pathological factors, and bamboo rhizome directly promotes bone growth. Together, they construct a complex mechanism of "conditioning, clearing obstacles, and promoting growth," and none of them can be omitted.

[0185] Test Example 2

[0186] Ninety children aged 8-10 years were recruited, with a gender ratio of 1:1. The treatment period was one year, during which their diet, rest, and exercise routines were maintained. The subjects were divided into three groups of 30 each (gender ratio 1:1). Group 1 used the patch corresponding to Example 3 of this application, applied to the Yongquan acupoint and Zusanli acupoint twice a week for 8-10 hours. Group 2 used the patch corresponding to Comparative Example 5 of this application, and used it as described above. Group 3 used the patch corresponding to the blank control of this application, and used it as described above.

[0187] After one year of use, height growth was monitored, and the results are shown in Table 2 below:

[0188] Group Average height increase (cm) growth rate(%) Group 1 7.7±0.8 5.89 Group 2 5.8±0.6 4.44 Group 3 4.9±0.8 4.15

[0189] As the data above shows, Group 1 performed best in promoting height growth, with an average annual height increase of 7.7cm, which was significantly higher than Group 3 (blank control group). This indicates that the patch in Example 3 promotes children's height growth and shows great application potential in the preparation of pediatric growth-promoting drugs.

[0190] Although the present invention has been described in detail above with general descriptions and specific embodiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. A pediatric growth-promoting preparation, characterized in that, It consists of the following components in parts by weight: 3-10 servings of Alpinia oxyphylla 2-10 portions of Codonopsis pilosula 3-9 parts dried ginger 2-8 servings of hawthorn Angelica sinensis 3-10 parts 2-10 portions of Amomum villosum 2-10 parts of Tibetan incense 3-12 portions of dried tangerine peel June Snow 2-6 portions 2-8 portions of bamboo joint ginseng 2-8 parts of Cibotium barometz 1-10 portions of beef bone meal Scrophularia ningpoensis 3-10 parts.

2. The pediatric growth-promoting preparation as described in claim 1, characterized in that, It consists of the following components in parts by weight: 4-7 portions of Alpinia oxyphylla 2-5 portions of Codonopsis pilosula 3-7 parts dried ginger 3-6 servings of hawthorn Angelica sinensis 4-7 parts 2-5 parts of Amomum villosum 2-6 parts of Tibetan incense 4-10 portions of dried tangerine peel June Snow 2-5 portions 3-6 portions of bamboo joint ginseng 2-5 portions of Cibotium barometz 3-6 parts beef bone meal Scrophularia ningpoensis 4-10 parts.

3. The pediatric growth-promoting preparation as described in claim 2, characterized in that, It consists of the following components in parts by weight: 5 portions of Alpinia oxyphylla 3 portions of Codonopsis pilosula 5 parts dried ginger 5 portions of hawthorn 5 parts Angelica sinensis 3 parts of cardamom 3 portions of Tibetan incense 6 portions of dried tangerine peel 5 portions of June Snow 5 portions of bamboo joint ginseng 5 portions of Cibotium barometz 5 portions of beef bone meal Six parts of Scrophularia ningpoensis.

4. A method for preparing a pediatric growth-promoting agent, used to prepare the pediatric growth-promoting agent as described in claim 1, characterized in that, The processing steps are as follows: Weigh out the following ingredients according to the specified proportions: Alpinia oxyphylla, Codonopsis pilosula, dried ginger, hawthorn, Angelica sinensis, Amomum villosum, Aucklandia lappa, dried tangerine peel, Serissa japonica, Panax japonicus, Cibotium barometz, Scrophularia ningpoensis, and ox bone powder. Grind them to a particle size of 200 mesh and set aside. Take Alpinia oxyphylla, Codonopsis pilosula, dried ginger, hawthorn, Angelica sinensis, Amomum villosum, Aucklandia lappa, tangerine peel, Serissa japonica, Panax japonicus, Cibotium barometz and Scrophularia ningpoensis, soak them in 70% ethanol aqueous solution, concentrate under reduced pressure, dry under reduced pressure into powder, mix with bovine bone powder, add while stirring until evenly mixed to obtain a pediatric growth-promoting preparation.

5. The application of the method for preparing the pediatric growth-promoting preparation as described in claim 4 in the preparation of pediatric growth-promoting patches, ointments, oils, or capsules.

6. The application as described in claim 5, characterized in that, The production of pediatric growth-promoting patches also includes the following steps: The silicone, rubber, or hot melt adhesive matrix is ​​heated and melted, and a pediatric growth promoter is added while stirring until it is completely mixed to obtain a mixture. Add the mixture into the mold, let it cool and set, and set aside.

7. The application as described in claim 5, characterized in that, When producing ointments, the following steps are also included: Add the pediatric growth-promoting preparation to deionized water according to the specified ratio and soak for 6-12 hours. Filter to obtain the filtrate for later use. The above filtrate is heated and evaporated, concentrated to 1 / 10 of its original volume, and then an appropriate amount of hardening agent is added and mixed to obtain a paste.

8. The application as described in claim 5, characterized in that, When producing oils, the following steps are also included: The pediatric growth-promoting agent is added to vegetable oil in a certain proportion and heated and soaked for 2-4 hours. After filtration, the filtrate is concentrated to obtain the oil.

9. The application as described in claim 5, characterized in that, The production of capsules also includes the following steps: Pediatric growth promoters are mixed with binders to form uniform granules, which are then filled into capsule shells to obtain capsules.

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