Preparation process and use method of bone disease compound nutritional supplement based on bone marrow hematopoietic microenvironment

Abstract

The invention discloses a preparation process and a use method of a bone disease compound nutritional supplement based on a bone marrow hematopoietic microenvironment, and relates to the field of bone marrow hematopoietic microenvironment nutritional supplement.The bone disease compound nutritional supplement comprises a nutritional plate, a balance plate and an auxiliary plate; the nutritional plate comprises sodium hyaluronate, marine fishbone collagen oligopeptide, wheat oligopeptide and chitosan oligosaccharide, and the sodium hyaluronate comprises middle molecules, small molecules and oligomeric molecules; according to the preparation process and the use method of the bone disease compound nutritional supplement based on the bone marrow hematopoiesis microenvironment, the bone marrow hematopoiesis microenvironment is comprehensively adjusted and improved from multiple aspects through the synergistic effect of the nutrition plate, the balance plate and the auxiliary plate, and the three plates are matched with one another and supplement one another, so that the bone disease compound nutritional supplement has the effect of improving the bone marrow hematopoiesis microenvironment. Therefore, the purposes of treating bone diseases and maintaining bone health are achieved, the limitation of treatment with a single nutritional supplement is correspondingly overcome, and a brand-new and effective solution is provided for treatment of bone diseases.

Description

TECHNICAL FIELD

[0001] The present application relates to bone marrow hematopoietic microenvironment nutrition supplement technology, and in particular to a preparation process and use method of a bone disease composite nutritional supplement based on a bone marrow hematopoietic microenvironment. BACKGROUND

[0002] As the key organ of the human movement system, the skeleton plays an irreplaceable role in physiological functions such as human movement, support, and protection. Hard bone is composed of periosteum, bone, and bone marrow, and its components include inorganic substances (such as calcium, magnesium, phosphorus, sulfur, etc.) and organic substances (such as collagen and white peptides). Periosteum is rich in blood vessels and nerves, and osteoblasts and osteoclasts in bone maintain metabolic balance. Red bone marrow in bone marrow, as the most active tissue inside, has hematopoietic function. Bone marrow hematopoietic microenvironment is the core of the skeletal organ. Hard bone is connected to a precise organic whole through joints, ligaments, or cartilage. However, when any link of the skeleton and bone connection is problematic, various bone diseases such as common bone and joint diseases, lumbar diseases, and osteoporosis occur. These bone diseases not only seriously affect the quality of life of patients but also bring heavy economic burden and mental stress to patients and their families. Therefore, there is an urgent need to seek effective bone disease treatment methods.

[0003] The existing treatment methods lack targeted nutritional support for bone marrow hematopoietic microenvironments, cannot effectively regulate cell function, extracellular matrix components, and physicochemical properties of the microenvironment in the bone marrow hematopoietic microenvironment, and thus cannot achieve comprehensive and effective treatment of bone diseases. Therefore, a preparation process and use method of a bone disease composite nutritional supplement based on a bone marrow hematopoietic microenvironment are proposed. SUMMARY

[0004] The purpose of the present application is to provide a preparation process and use method of a bone disease composite nutritional supplement based on a bone marrow hematopoietic microenvironment to solve the problem that the existing treatment methods lack targeted nutritional support for bone marrow hematopoietic microenvironments, cannot effectively regulate cell function, extracellular matrix components, and physicochemical properties of the microenvironment in the bone marrow hematopoietic microenvironment, and thus cannot achieve comprehensive and effective treatment of bone diseases.

[0005] To achieve the above-mentioned purpose, the present application provides the following technical solution: a preparation process of a bone disease composite nutritional supplement based on a bone marrow hematopoietic microenvironment, including a nutrition block, a balance block, and an auxiliary block.

[0006] The nutrition block includes sodium hyaluronate, marine fish bone collagen oligopeptide, wheat oligopeptide, and chitooligosaccharide. The sodium hyaluronate contains medium molecules, small molecules, and oligomolecules.

[0007] The balance plate includes maltitol, xylitol, xylose, erythritol, calcium gluconate, magnesium sulfate, potassium citrate and sodium citrate.

[0008] The auxiliary plate includes taurine, niacin, beetroot powder and cabbage powder, and it is noted that the beetroot powder and cabbage powder can be selectively added.

[0009] Further, the raw material content of the sodium hyaluronate is 0.01-0.05 parts, and the ratio of the medium molecule, small molecule and oligomer in the sodium hyaluronate is 3:4:3.

[0010] Further, the molecular weight of the medium molecule is 1 million Da (inclusive) -1.8 million Da, the molecular weight of the small molecule is 10,000 Da (inclusive) -1 million Da, and the molecular weight of the oligomer is less than 10,000 Da.

[0011] Further, the raw material content of the maltitol is 2-3 parts; the raw material content of the xylitol is 0.2-1 part; the raw material content of the xylose is 0.02-0.2 part; the raw material content of the erythritol is 2-3 parts; the raw material content of the calcium gluconate is 0.1-0.3 parts; the raw material content of the magnesium sulfate is 0.03-0.08 parts; the raw material content of the potassium citrate is 0.01-0.05 parts; and the raw material content of the sodium citrate is 0.01-0.05 parts.

[0012] Further, the raw material content of the taurine is 0.01-0.05 parts; the raw material content of the niacin is 0.001-0.0016 parts; the raw material content of the beetroot powder is 0.1-0.5 parts; and the raw material content of the cabbage powder is 0.1-0.5 parts.

[0013] A preparation method of a bone disease composite nutritional supplement based on bone marrow hematopoietic microenvironment, comprising the following steps:

[0014] Step one: first, the nutritional plate and the balance plate are dissolved in deionized water respectively and then mixed;

[0015] Step two: the auxiliary plate raw materials are added to the above mixture, heated, and the mixture is filled into glass bottles, plastic bottles or bags and sealed;

[0016] Step three: sterilize the mixture to finally produce the finished product.

[0017] Further, the raw material content of the deionized water is 87.2-94.4 parts, and the heating temperature of the mixture is 60-80 degrees.

[0018] Further, the sterilization temperature is 105-121 degrees, the sterilization time is 40 minutes, and the pH value of the supplement finished product is 7.3-8.3.

[0019] Compared with the prior art, the preparation process and use method of the bone disease composite nutritional supplement based on bone marrow hematopoietic microenvironment provided by the application start from the key source of bone disease, i.e., bone marrow hematopoietic microenvironment. The sodium hyaluronate in the nutritional plate includes medium molecules, small molecules and oligomeric molecules in a precise ratio of 3:4:3. The sodium hyaluronate with different molecular weights plays a synergistic role. The medium molecular weight sodium hyaluronate can form a stable extracellular matrix structure in the bone marrow hematopoietic microenvironment, providing physical support and a suitable living environment for hematopoietic stem cells and bone cells. The small molecular weight sodium hyaluronate can better penetrate cells, participate in cell metabolism and regulate cell signal transduction. The oligomeric sodium hyaluronate has high biological activity, can activate cell surface receptors, regulate cell gene expression and enhance cell immunity and antioxidant capacity. The three work together to comprehensively regulate the physiological functions of the bone marrow hematopoietic microenvironment and maintain its homeostasis, laying a foundation for bone health. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed in the embodiments will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments described in the present application, and other drawings can also be obtained by those skilled in the art based on these drawings.

[0021] Figure 1 The preparation flow chart of the composite nutritional supplement for the embodiments of the present application is provided. DETAILED DESCRIPTION

[0022] In order to enable those skilled in the art to better understand the technical solutions of the present application, the present application will be further described in detail with reference to the drawings.

[0023] As shown in the accompanying Figure 1 , the present application provides a preparation process of a bone disease composite nutritional supplement based on bone marrow hematopoietic microenvironment.

[0024] The preparation process of the bone disease composite nutritional supplement based on bone marrow hematopoietic microenvironment comprises a nutritional plate, a balance plate and an auxiliary plate.

[0025] The nutritional plate comprises sodium hyaluronate, marine fish bone collagen oligopeptide, wheat oligopeptide and chitooligosaccharide, and the sodium hyaluronate includes medium molecules, small molecules and oligomeric molecules.

[0026] According to the further specific details of the present application, the content of the raw material of the sodium hyaluronate is 0.01-0.05 parts, the ratio of the medium molecules, small molecules and oligomeric molecules in the sodium hyaluronate is 3:4:3, the molecular weight of the medium molecules is 1 million Da (inclusive) -1.8 million Da, the molecular weight of the small molecules is 10,000 Da (inclusive) -1 million Da, and the molecular weight of the oligomeric molecules is less than 10,000 Da.

[0027] The balance plate includes maltitol, xylitol, xylose, erythritol, calcium gluconate, magnesium sulfate, potassium citrate and sodium citrate;

[0028] The further specific details of the application are that the raw material content of maltitol is 2-3 parts; the raw material content of xylitol is 0.2-1 part; the raw material content of xylose is 0.02-0.2 part; the raw material content of erythritol is 2-3 parts; the raw material content of calcium gluconate is 0.1-0.3 part; the raw material content of magnesium sulfate is 0.03-0.08 part; the raw material content of potassium citrate is 0.01-0.05 part; and the raw material content of sodium citrate is 0.01-0.05 part;

[0029] The auxiliary plate includes taurine, nicotinic acid, beetroot powder and cabbage powder, and it is to be noted that the beetroot powder and the cabbage powder can be selectively added;

[0030] The further specific details of the application are that the raw material content of taurine is 0.01-0.05 part; the raw material content of nicotinic acid is 0.001-0.0016 part; the raw material content of beetroot powder is 0.1-0.5 part; and the raw material content of cabbage powder is 0.1-0.5 part;

[0031] A preparation method of a bone disease composite nutritional supplement based on a bone marrow hematopoietic microenvironment, comprising the following steps:

[0032] Step one: first, the nutrition plate and the balance plate are respectively dissolved with deionized water and then mixed;

[0033] Step two: the auxiliary plate raw materials are added to the above-mentioned mixed solution, heated, and the mixed solution is sealed in glass bottles, plastic bottles or bags;

[0034] Step three: the mixed solution is sterilized, and finally the finished product is prepared.

[0035] The further specific details of the application are that the raw material content of deionized water is 87.2-94.4 parts, the heating temperature of the mixed solution is 60-80 degrees; the sterilization temperature is 105-121 degrees, the sterilization time is 40 minutes, and the pH value of the supplement finished product is 7.3-8.3;

[0036] The working principle of the application is as follows:

[0037] Based on the core position of bone marrow hematopoietic microenvironment in bone health: the bone marrow hematopoietic microenvironment is the core functional area of the skeletal system, which plays an irreplaceable key role in maintaining bone health and normal physiological function, not only provides a suitable survival and differentiation place for hematopoietic stem cells, ensures normal hematopoietic function of the human body, but also participates in the metabolic regulation of bone cells, the synthesis and degradation of extracellular matrix and other processes, which has a profound influence on the growth, development, repair and remodeling of the skeleton, when the bone marrow hematopoietic microenvironment is affected by various factors (such as age, disease, bad living habits, etc.) and becomes disordered, it will cause the abnormal function of bone cells, and then cause a series of bone diseases, such as osteoporosis, osteoarthritis, etc., therefore, starting from the bone marrow hematopoietic microenvironment, targeted nutrition supplement and regulation, is an effective way to treat bone diseases and maintain bone health, the composite nutritional supplement of the application is based on this important principle, through the synergistic effect of multiple plates, the bone marrow hematopoietic microenvironment is comprehensively regulated, so as to achieve the purpose of treating bone diseases;

[0038] Sodium hyaluronate occupies a key position in the nutrition plate, which contains medium molecular weight, small molecular weight and oligomeric molecules, and the proportion is strictly controlled at 3:4:3, this precise ratio is based on the unique effect of sodium hyaluronate with different molecular weights in the bone marrow hematopoietic microenvironment, medium molecular weight sodium hyaluronate (molecular weight 100-180 million Da) has higher viscoelasticity, which can form a stable extracellular matrix structure in the bone marrow hematopoietic microenvironment, providing physical support and protection for hematopoietic stem cells and bone cells, maintaining the normal morphology and function of cells, small molecular weight sodium hyaluronate (molecular weight 10-100 million Da) has better permeability, which can more easily penetrate the cell membrane, enter the cell interior, participate in the metabolic process of the cell, regulate the signal transduction of the cell, promote the proliferation and differentiation of the cell, and oligomeric sodium hyaluronate (molecular weight less than 10,000 Da) has stronger biological activity, which can activate the receptors on the cell surface, start a series of intracellular signaling pathways, regulate the gene expression of the cell, and enhance the immune function and antioxidant capacity of the cell, three different molecular weight sodium hyaluronates synergistically regulate and improve the bone marrow hematopoietic microenvironment from different levels and angles, and provide comprehensive support for bone health;

[0039] Marine fish bone collagen oligopeptides and wheat oligopeptides are high-quality protein nutrients, which have the characteristics of small molecular weight and easy absorption. In the bone marrow hematopoietic microenvironment, these oligopeptides can be quickly taken up and utilized by cells, providing abundant amino acids for bone cells and hematopoietic stem cells to meet the needs of cell growth, repair and metabolism. At the same time, oligopeptides also have certain biological activities, which can regulate the immune function of cells, enhance the resistance of cells, promote the proliferation and differentiation of cells, and help maintain the stability of the bone marrow hematopoietic microenvironment. Chitooligosaccharides have the function of regulating extracellular matrix metabolism, which can promote the synthesis of collagen, enhance the strength and stability of the extracellular matrix, and improve the structure of the bone marrow hematopoietic microenvironment. In addition, chitooligosaccharides also have immunomodulatory, antioxidant and other biological activities, which can improve the body's immunity and reduce the damage of oxidative stress to the bone marrow hematopoietic microenvironment, creating a good internal environment for bone health.

[0040] Sugar alcohol components such as maltitol, xylitol, xylose and erythritol in the balance plate play an important role in maintaining the osmotic pressure and water balance of the bone marrow hematopoietic microenvironment. These sugar alcohols have similar chemical structures to glucose, but have lower sweetness and are not easily digested and absorbed by the human body, which can form a certain osmotic pressure in the body and regulate the water distribution inside and outside the cells. By reasonably matching these sugar alcohols, the osmotic pressure environment of the human body fluid can be simulated, so that the cells in the bone marrow hematopoietic microenvironment are in a suitable water state, avoiding damage to cells due to excessive or insufficient water, and maintaining the normal physiological function of cells.

[0041] Mineral components such as calcium gluconate, magnesium sulfate, potassium citrate and sodium citrate jointly participate in the regulation of ion balance in the bone marrow hematopoietic microenvironment. Calcium is an important component of bones and teeth, and is crucial for maintaining the strength and hardness of bones. Calcium gluconate can provide sufficient calcium ions for the bone marrow hematopoietic microenvironment, promoting the calcification process of bone cells and enhancing the strength of bones. Magnesium is an activator of various enzymes and participates in energy metabolism and signal transduction processes in cells. Magnesium sulfate can regulate the concentration of magnesium ions in cells, maintaining normal metabolism and function of cells. Potassium and sodium are important ions for maintaining the potential difference between the inside and outside of cells, playing a key role in cell excitability and signal transduction. Potassium citrate and sodium citrate can regulate the potassium and sodium balance inside and outside the cells, maintaining the normal potential of cells and ensuring the normal signal transduction and physiological function of cells. Through the synergistic effect of these minerals, the ion balance in the bone marrow hematopoietic microenvironment can be maintained, providing the necessary conditions for the normal physiological activities of cells.

[0042] Taurine is a sulfur-containing non-protein amino acid with multiple important physiological functions in the human body. In the bone marrow hematopoietic microenvironment, taurine can promote cell absorption and utilization of nutrients, improve cell metabolic activity, regulate cell membrane fluidity, increase cell membrane permeability to nutrients, make nutrients more easily enter the cell interior, and has antioxidant effect, can remove free radicals in the body, reduce oxidative stress damage to cells, protect the normal function of cells. Nicotinic acid is a water-soluble vitamin involved in energy metabolism in the human body, which can promote the metabolism of fat, protein and carbohydrate, provide sufficient energy for cells in the bone marrow hematopoietic microenvironment. In addition, nicotinic acid also has the effect of dilating blood vessels, which can improve the blood circulation of the bone marrow hematopoietic microenvironment, increase the supply of nutrients and the discharge of metabolic waste, and promote the healthy growth and repair of cells.

[0043] Beetroot powder and cabbage powder are rich in vitamins, minerals and bioactive ingredients such as vitamin C, vitamin K, folic acid, potassium, magnesium and flavonoids, which have antioxidant, anti-inflammatory, immune regulation and other biological activities, can enhance the nutritional support of bone marrow hematopoietic microenvironment, improve the immunity of the body, reduce the damage of inflammatory reaction to bone marrow hematopoietic microenvironment, and selectively add beetroot powder and cabbage powder to meet the needs of different individuals and health conditions, further enhance the efficacy of the compound nutritional supplement, and provide more comprehensive protection for bone health.

[0044] The compound nutritional supplement of the present application can comprehensively regulate and improve the bone marrow hematopoietic microenvironment from multiple aspects through the synergistic effect of the nutrition block, the balance block and the auxiliary block. The nutrition block provides rich nutrients for the bone marrow hematopoietic microenvironment, supports cell growth, repair and metabolism; the balance block maintains the osmotic pressure, water balance and ion balance of the bone marrow hematopoietic microenvironment, and creates a stable internal environment for cells; the auxiliary block promotes the absorption and utilization of nutrients, enhances the metabolic activity and function of cells, and the three blocks complement each other to regulate the physiological function of the bone marrow hematopoietic microenvironment, promote the healthy growth and repair of bone cells, so as to achieve the purpose of treating bone disease and maintaining bone health. This innovative design of multi-block synergistic effect overcomes the limitations of single nutritional supplement treatment, and provides a new and effective solution for the treatment of bone disease.

[0045] By the arrangement of the above technical scheme, the present composite nutritional supplement starts from the key source of bone disease, i.e. bone marrow hematopoietic microenvironment. The sodium hyaluronate in the nutritional plate includes medium molecules, small molecules and oligomeric molecules in a precise ratio of 3:4:3. The sodium hyaluronate with different molecular weights plays a synergistic role. The medium molecular weight sodium hyaluronate can form a stable extracellular matrix structure in the bone marrow hematopoietic microenvironment, providing physical support and a suitable living environment for hematopoietic stem cells and bone cells. The small molecular weight sodium hyaluronate can better penetrate cells, participate in cell metabolism, and regulate cell signal transduction. The oligomeric sodium hyaluronate has high biological activity, can activate cell surface receptors, regulate cell gene expression, and enhance cell immunity and antioxidant capacity. The three work together to comprehensively regulate the physiological function of the bone marrow hematopoietic microenvironment and maintain its homeostasis, laying a foundation for bone health.

[0046] The marine fish bone collagen oligopeptide and wheat oligopeptide as high-quality protein sources have small molecular weight and are easy to absorb. They can quickly provide abundant amino acids for hematopoietic stem cells and bone cells in the bone marrow, meeting the needs of cell growth, repair and metabolism. At the same time, these oligopeptides also have biological activity, can regulate cell immune function, enhance cell resistance, promote cell proliferation and differentiation, help restore bone marrow hematopoietic function, and improve the ability of bone marrow to produce healthy blood cells and bone cells, fundamentally improving bone disease caused by abnormal bone marrow hematopoietic function.

[0047] In addition to sodium hyaluronate and oligopeptides, chitosan oligosaccharide in the nutritional plate also plays an important role. Chitosan oligosaccharide can regulate extracellular matrix metabolism, promote collagen synthesis, enhance the strength and stability of extracellular matrix, and improve the structure of bone marrow hematopoietic microenvironment. In addition, it also has immune regulation and antioxidant functions, can improve the body's immunity, reduce the damage of oxidative stress to the bone marrow hematopoietic microenvironment, and provide all-round protection for bone cells, ensuring the normal physiological function of cells.

[0048] The sugar alcohol components in the balance plate, such as maltitol, xylitol, xylose and erythritol, can simulate the osmotic pressure environment of human body fluid by reasonable proportioning, maintain the osmotic pressure and water balance in the bone marrow hematopoietic microenvironment, and make the cells in a suitable water state, avoiding cell damage due to water imbalance. The mineral components such as calcium gluconate, magnesium sulfate, potassium citrate and sodium citrate can synergistically regulate the ion balance inside and outside the cells. Calcium is an important component of bone, and calcium gluconate can provide sufficient calcium ions to promote bone cell calcification. Magnesium acts as an activator for a variety of enzymes and participates in cell energy metabolism. Potassium and sodium maintain the potential difference inside and outside the cells, and potassium citrate and sodium citrate regulate the potassium and sodium balance, together ensuring the normal signal transduction and physiological function of cells.

[0049] Taurine in the auxiliary plate can adjust the cell membrane fluidity, increase the permeability of the cell membrane to nutrients, promote the absorption and utilization of nutrients in the nutrition plate and the balance plate by cells, and improve the metabolic activity of cells. Nicotinic acid is involved in human energy metabolism, promotes the metabolism of fat, protein and carbohydrate, provides sufficient energy for cells in the bone marrow hematopoietic microenvironment, expands blood vessels, improves blood circulation in the bone marrow hematopoietic microenvironment, increases the supply of nutrients and the discharge of metabolic waste, and has the effects of anti-oxidation, anti-inflammation, immune regulation, etc. Selective addition can further enhance nutritional support and improve immunity and reduce the damage of inflammatory reaction to the bone marrow hematopoietic microenvironment according to individual needs;

[0050] The content of each plate in the compound nutritional supplement is accurately specified, for example, the content of sodium hyaluronate is 0.01-0.05 parts, and the medium molecular, small molecular and oligomeric molecules are strictly matched in a ratio of 3:4:3; the content of marine fish bone collagen oligopeptide is 0.5-2 parts, and the content of wheat oligopeptide is 0.5-2 parts. This accurate ratio is based on a large number of experimental researches and clinical practices to ensure that each component can exert the best synergistic effect, meet the human nutritional needs, and avoid affecting the product efficacy due to excessive or insufficient components;

[0051] In the preparation process, the nutrition plate and the balance plate are first dissolved in 87.2-94.4 parts of deionized water respectively, then mixed to ensure uniform dispersion of each component, and then the auxiliary plate raw materials are added to the mixed solution and heated to 60-80 degrees. This temperature can promote the dissolution and mixing of the raw materials and maximize the biological activity of each component. Then the mixed solution is filled into glass bottles, plastic bottles or bags and sealed to prevent external pollution. Finally, the product is sterilized at 105-121 degrees for 40 minutes to ensure its sterility and safety and stability. At the same time, the pH value of the supplement product is controlled at 7.3-8.3, close to the pH value of human body fluid, reducing the irritation to the human body and improving the applicability and comfort of the product;

[0052] For patients with osteoporosis, osteoarthritis and other bone diseases, the compound nutritional supplement can be used as an auxiliary treatment method to regulate the bone marrow hematopoietic microenvironment, promote the growth and repair of bone cells, enhance the strength of the skeleton, relieve the symptoms of bone disease, and improve the quality of life of patients. Compared with traditional drug therapy, the product is based on nutritional regulation, has less side effects, and is more suitable for long-term use;

[0053] With the growth of age, the bone marrow hematopoietic function and the bone metabolism ability of human body gradually decline, and it is easy to have osteoporosis and other problems, the compound nutritional supplement can provide comprehensive nutritional support for the middle-aged and old people, adjust the bone marrow hematopoietic microenvironment, maintain the bone health, prevent the occurrence of bone disease, and is an ideal choice for the daily bone health care of the middle-aged and old people;

[0054] For athletes, physical laborers and other people with high requirements for bone health, and postoperative rehabilitation patients and other people needing additional nutritional support, the product can meet the special needs of them for bone nutrition, and the rich nutritional ingredients and scientific formula can help to accelerate bone repair and rehabilitation, and improve the resistance and recovery ability of the body.

[0055] The above only describes some exemplary embodiments of the present application in a descriptive way, and it is needless to say that the described embodiments can be modified in various ways without departing from the spirit and scope of the present application for those skilled in the art. Therefore, the above drawings and descriptions are illustrative in nature and should not be understood as limiting the scope of protection of the claims of the present application.

Claims

1. A preparation process for a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment, characterized in that, It includes a nutrition section, a balance section, and a supplementary section; The nutritional components include sodium hyaluronate, marine fish bone collagen oligopeptides, wheat oligopeptides, and chitosan oligosaccharides, wherein the sodium hyaluronate comprises medium-molecular-weight, small-molecular-weight, and oligomeric molecules; The balancing plate includes maltitol, xylitol, xylose, erythritol, calcium gluconate, magnesium sulfate, potassium citrate, and sodium citrate; The auxiliary components include taurine, niacin, beetroot powder, and cabbage powder.

2. The preparation process of a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment according to claim 1, characterized in that, The raw material content of the sodium hyaluronate is 0.01 to 0.05 parts, and the ratio of medium molecular weight, small molecular weight and oligomeric molecular weight in the sodium hyaluronate is 3:4:

3.

3. The preparation process of a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment according to claim 1, characterized in that, The molecular weight of the medium molecule is 1,000,000 Da (inclusive) to 1,800,000 Da, the molecular weight of the small molecule is 10,000 Da (inclusive) to 1,000,000 Da, and the molecular weight of the oligomer is less than 10,000 Da.

4. The preparation process of a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment according to claim 1, characterized in that, The raw material content of maltitol is 2-3 parts; the raw material content of xylitol is 0.2-1 parts; the raw material content of xylose is 0.02-0.2 parts; the raw material content of erythritol is 2-3 parts; the raw material content of calcium gluconate is 0.1-0.3 parts; the raw material content of magnesium sulfate is 0.03-0.08 parts; the raw material content of potassium citrate is 0.01-0.05 parts; and the raw material content of sodium citrate is 0.01-0.05 parts.

5. The preparation process of a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment according to claim 1, characterized in that, The raw material content of taurine is 0.01 to 0.05 parts; the raw material content of niacin is 0.001 to 0.0016 parts; the raw material content of beetroot powder is 0.1 to 0.5 parts; and the raw material content of cabbage powder is 0.1 to 0.5 parts.

6. A method for preparing a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment, characterized in that, Includes the following steps: Step 1: First, dissolve the nutrient block and the balance block separately in deionized water until fully dissolved, then mix them together; Step 2: Add the auxiliary material to the above mixture, heat it, and seal the mixture in glass bottles, plastic bottles or bags; Step 3: Sterilize the mixture to produce the final product.

7. The preparation process of a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment according to claim 6, characterized in that, The raw material content of the deionized water is 87.2 to 94.4 parts, and the heating temperature of the mixture is 60 to 80 degrees Celsius.

8. The preparation process of a compound nutritional supplement for bone diseases based on the bone marrow hematopoietic microenvironment according to claim 6, characterized in that, The sterilization temperature is 105–121 degrees Celsius, the sterilization time is 40 minutes, and the pH value of the finished supplement is 7.3–8.3.

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