Protein component composition with special medical purpose as well as preparation method and application of protein component composition

Abstract

The invention provides a protein component composition with special medical application as well as a preparation method and application thereof, and relates to the field of formula food with special medical application. Wherein the protein component composition comprises protein and a sweetening agent; the protein is one or more of hydrolyzed whey protein powder, hydrolyzed casein and albumin peptide. The sweetening agent is one or more of white granulated sugar, glucose syrup, malt syrup, high fructose corn syrup, erythritol, xylitol, maltitol and stevioside. A plurality of components such as a stabilizer, mineral substances and multivitamins can also be added into the protein component composition. The finally obtained composition can be applied to preparation of formula food for special medical purposes, and the content of total protein, hemoglobin, albumin or transferrin in blood of patients suffering from malnutrition or insufficient protein intake is increased.

Description

Technical Field

[0001] This invention relates to the field of compositions for special medical purposes, specifically to a protein component composition for special medical purposes, its preparation method, and its application. Background Technology

[0002] Proteins are the most abundant and functionally diverse macromolecules in cells. They play a crucial role in almost all life processes. The functional diversity of proteins is determined by their structural differences. Enzymes that catalyze metabolic processes, antibodies that provide defense, and hemoglobin that transports oxygen in the body are all proteins.

[0003] When the human body loses more than 20% of its protein, vital functions are forced to cease. This is seen in people suffering from poverty and hunger, as well as in patients with cachexia due to prolonged illness. Clinical manifestations of protein deficiency include fatigue, weight loss, anemia, decreased immunity and stress response, decreased hemoglobin levels, especially albumin, and nutritional edema. Therefore, when protein deficiency occurs, protein should be replenished promptly.

[0004] Existing technologies often use single animal or plant proteins as the protein source for protein products. For example, patent application CN201911288443.4 discloses a method for producing digestible protein using animal protein (mainly lean meat and fish) as raw material. Digestible protein refers to small molecule proteins with a molecular weight below 500 Daltons, whose composition consists of complex amino acids with an average molecular weight of 120 Da and small molecule dipeptides and tripeptides of 180 to 500 Da. This type of protein does not require human digestion and can be directly absorbed and utilized by the human small intestine. Patent application CN201911361800.5 discloses a method for preparing a high branched-chain amino acid digestible corn protein product, which uses corn gluten powder as raw material for enzymatic hydrolysis to obtain a digestible corn protein product with a branched-chain amino acid content of about 22.24%. Undigestible protein products refer to small molecule proteins with a molecular weight below 500 Da; their composition consists of complex amino acids with an average molecular weight of 120 Da and small molecule dipeptides and tripeptides of 180 to 500 Da; this type of protein does not require human digestion and can be directly absorbed and utilized by the human small intestine. The aforementioned applications all suffer from problems such as simple amino acid patterns and low nutritional value. Furthermore, due to differences in preparation processes and product forms, the products have poor flowability, dispersibility, and wettability, making them unsuitable for consumption.

[0005] Therefore, there is an urgent need to develop a protein component formulation for special medical purposes to overcome the above problems. Summary of the Invention

[0006] The purpose of this invention is to provide a protein component composition for special medical purposes. The protein component composition provided by this invention is rapidly absorbed, has a high tolerance rate, a moderate taste, and is rich in nutrients.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] The present invention provides a protein component composition comprising a protein and a sweetener; wherein the protein is one or more selected from hydrolyzed whey protein powder, hydrolyzed casein, and albumin peptides; and the sweetener is one or more selected from granulated sugar, glucose syrup, maltose syrup, fructose syrup, erythritol, xylitol, maltitol, and steviol glycosides.

[0009] Preferably, the protein component composition includes stabilizers, minerals, and multivitamins in addition to proteins and sweeteners.

[0010] More preferably, the stabilizer is β-glucan, monoglyceride, sucrose ester or xanthan gum; the mineral is calcium citrate; and the complex vitamins include B vitamins and vitamin C.

[0011] Preferably, the protein component composition comprises, by weight, 75-85 parts water, 10-15 parts protein, 0.23-0.45 parts sweetener, 0.5-2 parts stabilizer, 1-3 parts minerals and 0.1-0.5 parts multivitamins.

[0012] The present invention also provides a method for preparing a protein component composition, comprising the following steps:

[0013] S1. Dissolve the sweetener in pure water to obtain a sweetener solution;

[0014] S2. Dissolve the stabilizer in pure water, add the protein and minerals and stir, add the sweetener solution and multivitamins, dissolve for 20-60 minutes, and then homogenize.

[0015] S3. The composition is obtained by steam immersion sterilization, aseptic homogenization and emulsification, and then aseptic filling.

[0016] Preferably, the dissolution temperature of the raw materials in steps S1 and S2 is 50-70°C.

[0017] Preferably, the steam immersion sterilization in step S2 is performed at a temperature of 140-150°C for 2-8 seconds.

[0018] Preferably, the homogenization emulsification pressure in steps S2 and S3 is 20±2MPa, the temperature is 50-60℃, and the cycle is 1-3 times.

[0019] The present invention also provides the application of the above-described protein component composition or the protein component composition prepared by the above-described preparation method in the preparation of foods for special medical purposes.

[0020] The present invention also provides the application of the above-described protein component composition or the protein component composition prepared by the above-described preparation method in increasing the levels of total protein, hemoglobin, albumin or transferrin in the blood of malnourished or protein-deficient patients.

[0021] The beneficial effects of this invention are:

[0022] The protein component composition prepared by this invention has high tolerance, moderate taste, and rich nutrition; it can effectively improve human immunity for people who need to supplement protein for specific diseases or medical conditions.

[0023] The protein component composition of this invention utilizes steam immersion sterilization, which refers to a sterilization method in which the product enters a vertical sterilization chamber filled with steam, descends from top to bottom of the chamber, and is simultaneously heated to a set sterilization temperature. Steam immersion sterilization can complete sterilization in a very short time (2-8 seconds), reducing the loss of nutrients in the product and giving it a better taste. Detailed Implementation

[0024] This invention provides a protein component composition comprising a protein and a sweetener; the protein is one or more selected from hydrolyzed whey protein powder, hydrolyzed casein, and albumin peptides; the sweetener is one or more selected from granulated sugar, glucose syrup, maltose syrup, fructose syrup, erythritol, xylitol, maltitol, and steviol glycosides. The composition further comprises a stabilizer, minerals, and a complex vitamin; the stabilizer is β-glucan, monoglycerides, sucrose esters, or xanthan gum; the mineral is calcium citrate; and the vitamins include B vitamins and vitamin C.

[0025] By weight, the protein component composition of the present invention comprises 75-85 parts water, 10-15 parts protein, 0.23-0.45 parts sweetener, 0.5-2 parts stabilizer, 1-3 parts minerals and 0.1-0.5 parts complex vitamins.

[0026] The method for preparing the protein component composition of the present invention includes the following steps:

[0027] S1. Dissolve the sweetener in pure water to obtain a sweetener solution;

[0028] S2. Dissolve the stabilizer in pure water, add the protein and minerals and stir. Add the compound vitamin and sweetener solution and dissolve for 20-60 minutes. Then homogenize at a pressure of 20±2MPa and a temperature of 50-60℃. Repeat 1-3 times.

[0029] S3. After steam sterilization, homogenization and emulsification are carried out to obtain the composition; wherein the homogenization pressure is 20±2MPa, the temperature is 50-60℃, and the cycle is 1-3 times.

[0030] Steam immersion sterilization refers to a sterilization method where the product enters a vertical sterilization chamber filled with steam, descends from top to bottom, and is simultaneously heated to the set sterilization temperature. Steam immersion sterilization can complete sterilization in a very short time (2-8 seconds), reducing the loss of nutrients in the product and giving it a better taste.

[0031] This invention first adds minerals and then homogenizes and emulsifies them at a pressure of 20±2MPa, which can break down protein aggregates to a particle size of ≤1μm; the temperature is controlled at 50-60℃ to maintain protein conformational activity and prevent denaturation; the number of cycles is 1-3 to ensure emulsification uniformity (CI≤0.15).

[0032] The results of the embodiments of the present invention show that the composition prepared by the present invention has a high tolerance rate, a moderate taste, and is rich in nutrients.

[0033] To further illustrate the present invention, the technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0034] Unless otherwise specified, the production processes, experimental methods, or testing methods involved in the embodiments of this invention are all conventional methods in the prior art, and their names and / or abbreviations are all conventional names in the field, which are very clear and distinct in the relevant application areas. Those skilled in the art can understand the conventional process steps based on the names and apply the corresponding equipment, and implement them according to conventional conditions or the conditions recommended by the manufacturer.

[0035] The various instruments, equipment, raw materials or reagents used in the embodiments of this invention are not subject to any special restrictions on their source. They are all conventional products that can be purchased through regular commercial channels and can be prepared according to conventional methods known to those skilled in the art.

[0036] Example 1: Preparation of the protein component composition (composition)

[0037] 1.1 Raw material preparation

[0038] The raw materials added during the preparation of the protein component composition include the following components by weight:

[0039] Water: 80 portions.

[0040] Protein: 10 parts hydrolyzed whey protein powder + 5 parts albumin peptides.

[0041] Sweetener: Erythritol and steviol glycosides are mixed in a 1:1 ratio, totaling 0.2 parts.

[0042] Excipients: 1.5 parts β-glucan, 1.2 parts calcium citrate, and 0.22 parts multivitamins (B vitamins and vitamin C in a 1:1 ratio).

[0043] 1.2 Preparation process

[0044] Sweeteners (erythritol + steviol glycosides) were dissolved in 60°C pure water to obtain a sweetener solution. Stabilizer (β-glucan) was dissolved in pure water, followed by the addition of protein (hydrolyzed whey protein powder + albumin peptides) and calcium citrate. The mixture was stirred, and then the sweetener solution was added. After thorough stirring, a complex vitamin mixture (B vitamins and vitamin C) was added and dissolved for 30 minutes. The mixture was then homogenized at 20 MPa and 55°C. After homogenization, it underwent steam immersion sterilization at 145°C for 8 seconds.

[0045] After sterilization, the mixture is subjected to aseptic homogenization again. The homogenization emulsification pressure is 22 MPa and the temperature is 85°C. The mixture is cycled once and then aseptically filled to obtain the composition.

[0046] Example 2 Preparation of protein component composition (composition)

[0047] 2.1 Raw material preparation

[0048] The raw materials added during the preparation of the protein component composition include the following components by weight:

[0049] Water: 75 portions.

[0050] Protein components: 5 parts hydrolyzed casein + 5 parts hydrolyzed whey protein + 5 parts albumin peptides.

[0051] Sweetener: 0.22 parts of a mixture of white sugar and steviol glycosides in a 1:1 ratio.

[0052] Excipients: 1.5 parts xanthan gum, 2 parts calcium citrate, 0.5 parts multivitamins.

[0053] 2.2 Preparation process

[0054] Sweetener (0.11 parts white sugar + 0.11 parts steviol glycosides) was dissolved in 60°C pure water to obtain a sweetener solution. Stabilizer (xanthan gum) was dissolved in pure water, and protein (5 parts hydrolyzed casein + 5 parts hydrolyzed whey protein + 5 parts albumin peptides) and calcium citrate were added and stirred. The sweetener solution was added, and after thorough stirring, a complex vitamin (a 1:1 mixture of B vitamins and vitamin C) was added and dissolved for 50 minutes. The mixture was then homogenized at 20 MPa and 60°C. After homogenization, it underwent steam immersion sterilization at 143°C for 4 seconds. After sterilization, it was again subjected to aseptic homogenization at 22 MPa and 75°C for emulsification, repeated three times. The final product was then aseptically filled to obtain the final composition.

[0055] The nutritional components (average values) of the compositions prepared in Examples 1-2 were analyzed, as shown in Table 1:

[0056] Table 1 Nutritional Information

[0057] Nutritional components per 100mL per 100kJ Energy (kJ) 306 100 Protein (g) 15.0 4.90 Fat (g) 0 0 Carbohydrates (g) 3 0.98 Sodium (mg) 169 55.23

[0058] Example 3: Verification Experiment of Protein Component Composition (Composition) Properties

[0059] Study Methods: Sixty participants with long-term malnutrition (insufficient protein intake) were recruited, and their blood samples were tested. The average value of the test results was taken.

[0060] Dosage: Take 100 mL of the protein component composition from Example 1 orally once a day.

[0061] Experimental conditions: The experimental period is 21 days.

[0062] Sample collection: Blood samples were collected from subjects on days 0, 7±2, and 21±2.

[0063] The blood sample test results are shown in Table 2:

[0064] Table 2 Blood Sample Test Results

[0065]

[0066]

[0067] The results showed that after 21 days of intervention, the levels of total protein, hemoglobin, albumin, and transferrin in the blood of 60 subjects were significantly improved.

[0068] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A protein assembly composition, characterized by, The protein component composition comprises protein and sweetener; the protein is one or more of hydrolyzed whey protein powder, hydrolyzed casein, albumin peptide; the sweetener is one or more of white granulated sugar, glucose syrup, maltose syrup, fructose syrup, erythritol, xylitol, maltitol and stevioside.

2. The protein assembly composition of claim 1, wherein, The protein component composition further comprises stabilizer, mineral and complex vitamin in addition to protein and sweetener.

3. The protein assembly composition of claim 2, wherein, The stabilizer is beta-glucan, monoglyceride, sucrose ester or xanthan gum; the mineral is calcium citrate; the complex vitamin comprises B vitamins and vitamin C.

4. The protein assembly composition of claim 2, wherein, The protein component composition comprises 75-85 parts by weight of water, 10-15 parts of protein, 0.23-0.45 parts of sweetener, 0.5-2 parts of stabilizer, 1-3 parts of mineral and 0.1-0.5 parts of complex vitamin.

5. A method of preparing a protein assembly composition, characterized by, The method comprises the following steps: S1, dissolving the sweetener in pure water to obtain a sweetener solution; S2, dissolving the stabilizer in pure water, adding the protein and the mineral and stirring, adding the sweetener solution and the complex vitamin, dissolving for 20-60 min, and then homogenizing; S3, steam immersion sterilization, aseptic homogenization and emulsification, and then aseptic filling to obtain the composition.

6. The preparation method according to claim 5, characterized in that, The dissolving temperature of the raw materials in steps S1 and S2 is 50-70℃.

7. The preparation method according to claim 5, characterized in that, The steam immersion sterilization in step S2 is performed at a sterilization temperature of 140-150℃ for 2-8 s.

8. The preparation method according to claim 5, characterized in that, The homogenization and emulsification in steps S2 and S3 are performed at a pressure of 20±2 MPa and a temperature of 50-60℃ for 1-3 cycles.

9. Use of the protein component composition of any one of claims 1-4 or prepared by the method of any one of claims 5-8 in the preparation of a special medical purpose formula.

10. Use of the protein component composition of any one of claims 1-4 or prepared by the method of any one of claims 5-8 in increasing the content of total protein, hemoglobin, albumin or transferrin in the blood of patients with malnutrition or insufficient protein intake.

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