Anti-pollution composition containing guaiazulene, and preparation method and application thereof

Abstract

The present application relates to the technical field of skin care products, and particularly relates to an anti-pollution composition containing guaiazulene and a preparation method and application thereof.The composition is composed of guaiazulene liposomes, kelp extract, date seed extract and schisandra chinensis extract, and achieves triple protection through the cascade effect of the four components.The composition can not only achieve the common effect of "adsorption-anti-inflammation-repair-soothing", but also has considerable soothing effect on skin sensitivity, itching and swelling induced by company decoration.The preparation method of the composition is simple and easy to operate, is conducive to industrialized large-scale production and application, meets market demand, and has strong market application value.

Description

Technical Field

[0001] This invention relates to the technical field of skincare products, specifically to an anti-pollution composition containing guaiac, its preparation method, and its application. Background Technology

[0002] As human civilization develops, people are paying more and more attention to healthy lifestyles, and their frequency and enthusiasm for participating in outdoor activities are also increasing. However, according to statistics from the World Health Organization, air quality in more than 80% of major cities worldwide fails to meet standards, and air pollution is becoming increasingly serious. Today, more and more skin problems are closely related to urban environmental pollution. Industrial emissions, vehicle exhaust, and particulate matter from various environmental factors can penetrate the skin, damage skin cells, and thus cause a variety of skin problems.

[0003] In the cosmetics industry, various technologies have been employed to address skin damage caused by external pollution and inflammation. Current mainstream solutions for anti-pollution skincare focus on single-dimensional physical or chemical antagonistic strategies. Silicone polymers, such as polydimethylsiloxane, block PM2.5 and other particulate matter through film formation, but long-term use can disrupt the skin's microecological balance, leading to increased follicle blockage, and are completely ineffective against water-soluble pollutants such as formaldehyde and benzene compounds. Antioxidant ingredients such as vitamin C derivatives, vitamin E, and ergothioneine can neutralize free radicals, but they cannot block the aryl hydrocarbon receptor (AhR) signaling pathway activated by pollutants. This pathway is the core mechanism inducing the release of inflammatory factors IL-6 / IL-8, and current products have an inhibition rate of less than 40%. Traditional soothing ingredients can only temporarily suppress redness but cannot repair the lipid structure of the stratum corneum damaged by pollutants, making barrier damage difficult to repair. Even more serious is that these technologies generally ignore the risk of microbial co-contamination, such as heavy metals in the renovation environment forming compound pollutants with harmful bacteria or fungi, while commercially available products generally have low antimicrobial rates and lack the ability to actively repair the skin barrier.

[0004] These issues reflect the cosmetics industry's urgent need for a skincare composition that soothes irritation and combats pollution, thereby meeting the market's pressing demand for highly effective, safe, and fast-responding products. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide an anti-pollution composition containing guaiac and its application. The raw material components in the composition work synergistically to achieve the combined effects of "adsorption-anti-inflammatory-repair-soothing", and also to provide considerable relief for skin sensitivity, itching and redness induced by company renovation.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] In a first aspect, the present invention provides an anti-pollution composition containing guaiac, comprising the following components: guaiac liposomes, giant kelp extract, date palm seed extract and Schisandra chinensis extract, wherein the weight ratio of the guaiac liposomes, giant kelp extract, date palm seed extract and Schisandra chinensis extract is (0.01-1):(0.01-3):(0.1-2):(0.01-3).

[0008] Guaifenesin is a deep blue crystalline hydrocarbon compound extracted from plants in the Asteraceae family (such as German chamomile), belonging to the chamomile ring derivatives. Its core mechanism involves inhibiting the release of inflammatory factors IL-1α, TNF-α, and MPO, blocking the inflammatory cascade reaction, while simultaneously upregulating the expression of repair factors TGF-β1 and VEGF, accelerating skin barrier reconstruction and angiogenesis. Through its antihistamine effect, it reduces capillary permeability, decreases neuropeptide P-mediated pruritus signaling, and directly inhibits the activation of capsaicin receptor TRPV1, relieving burning and stinging sensations. Furthermore, guaiacine can inhibit serotonin release, reduce allergen-induced edema, and has rapid soothing and tissue regeneration effects on burns, chemical irritants, and radiation damage.

[0009] Giant kelp extract, derived from giant brown algae in Antarctica, is rich in fucoidan and alginate. It forms a physical barrier against heavy metal ions (such as lead and cadmium) and adsorbs PM2.5 particles, reducing the penetration of environmental toxins. At the molecular level, it inhibits the expression of metalloproteinases (MMP-1 / 3), blocks UV and pollutant-induced collagen degradation, and reduces wrinkle formation. Giant kelp polysaccharide enhances the immune response of keratinocytes by activating TLR4 receptors, inhibits the colonization of pathogenic microorganisms such as Pseudomonas aeruginosa, and alleviates infectious redness.

[0010] Date palm seed extract, with polyphenols and gallic acid as its main active ingredients, enhances the deep epidermal water-locking capacity and increases the stratum corneum moisture content by activating aquaporin AQP3. It promotes the expression of filaggrin and hyaluronic acid synthase (HAS2), repairs damaged intercellular lipid structures of keratinocytes, and reduces transepidermal water loss (TEWL). Molecular mechanism studies show that this extract can downregulate NF-κB pathway activity, inhibit the release of pro-inflammatory factors such as IL-6 and IL-8, and alleviate neurogenic redness and swelling caused by chemical stimulation. It also synergistically regulates HGF / VEGF growth factors, accelerating collagen deposition and epithelial regeneration in wounds.

[0011] Schisandra chinensis extract contains schisandrin A and schisandrin B, biphenylcyclooctene lignans, as its core active ingredients. It works by scavenging DPPH free radicals and inhibiting lipid peroxidation, blocking ROS-induced oxidative damage to fibroblasts, and reducing photoaging collagen breakage. Key mechanisms include downregulating β-amyloid-induced inflammatory factors TNF-α / IL-1β, inhibiting excessive activation of the NF-κB signaling pathway, and alleviating neurogenic inflammatory responses. Schisandra chinensis extract can antagonize histamine H1 receptor expression, alleviating allergen-triggered capillary dilation. Furthermore, schisandrin B can enhance superoxide dismutase (SOD) activity, boosting the skin's own antioxidant defense system.

[0012] Preferably, the weight ratio of the guaiac liposomes, giant kelp extract, date seed extract, and schisandra extract is (0.05-0.5):(0.05-2):(0.5-1.2):(0.05-1.5).

[0013] More preferably, the weight ratio of the guaiac liposomes, giant kelp extract, date seed extract and schisandra extract is (0.1-0.3):(0.1-1):(0.6-0.8):(0.1-0.5).

[0014] Secondly, the present invention provides the application of the anti-pollution composition described in the first aspect in the preparation of skin care products.

[0015] Preferably, the skin care product is any one of toner, lotion, cream, mask, serum or spray, and the amount of the skin care composition added is 0.5%-5% of the total weight of the skin care product.

[0016] Thirdly, the present invention provides an essence comprising the following ingredients by weight percentage: 0.5%-5% of the anti-pollution composition described in the first aspect, 0.05%-0.3% of a thickener, 0.5%-10% of a moisturizer, 0.5%-1% of a preservative, and 0.01%-0.3% of a pH adjuster, with the balance being deionized water.

[0017] Preferably, the thickener includes at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, and sclerotium gum.

[0018] Preferably, the moisturizer comprises at least one of allantoin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, sodium hyaluronate, 1,3-butanediol, glycerin, budding stalk polysaccharide, and ceramide.

[0019] Preferably, the pH adjuster includes at least one of arginine, tromethamine, and disodium EDTA.

[0020] Preferably, the preservative includes at least one of 1,3-propanediol, 1,2-hexanediol, and p-hydroxyacetophenone.

[0021] Fourthly, the present invention provides a method for preparing the essence in the third aspect, comprising the following steps:

[0022] S1. Mix the humectant, thickener and part of deionized water, and homogenize to obtain an aqueous solution.

[0023] S2. When the temperature of the aqueous solution in S1 drops to 55-65℃, add the preservative and stir evenly. When the system temperature drops to 38-42℃, add each component of the anti-pollution composition described in the first aspect and the remaining deionized water, stir evenly, and finally add a pH adjuster to adjust the pH to obtain the essence.

[0024] Preferably, the homogenization temperature in step S1 is 75-85℃.

[0025] Preferably, in step S2, the pH is adjusted to 5.5-6.5.

[0026] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0027] This invention provides an anti-pollution composition containing guaiac, which is composed of guaiac liposomes, giant kelp extract, date seed extract, and Schisandra chinensis extract. The composition achieves triple protection through the cascade effect of these four components. Fucoidan in the giant kelp extract forms a negatively charged mesh film on the skin surface, capturing PM2.5 and chelating heavy metal ions (such as lead and cadmium) through electrostatic adsorption, reducing pollutant penetration at the source. Guaiac liposomes can target and inhibit the release of TNF-α / IL-1α downstream of the AhR pathway, while upregulating filaggrin synthesis, repairing the lipid structure of the stratum corneum damaged by pollutants, and shortening the barrier recovery rate. Schisandra chinensis extract scavenges pollutant-induced reactive oxygen species and blocks the NF-κB inflammatory cascade, providing dual protection against oxidation and neurogenic redness. Date palm seed extract activates aquaporin AQP3, increases the moisture content of the stratum corneum, regulates the skin microecology, inhibits the colonization of pathogenic microorganisms, and activates α-2A adrenaline receptors involved in vasoconstriction, thus soothing redness and itching. The composition not only achieves a combined effect of "adsorption-anti-inflammation-repair-soothing," but also has a significant soothing effect on skin sensitivity, itching, and redness induced by company renovations.

[0028] The preparation method of the composition provided by this invention is simple and easy to operate, which is conducive to large-scale industrial production and application, meets market demand, and has strong market application value. Attached Figure Description

[0029] Figure 1This is a comparison chart showing the use of the serum in test example 4 by volunteers before and after using the serum in application example 1. Detailed Implementation

[0030] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0031] The sources of the raw materials used in the following examples and comparative examples are as follows:

[0032] Guaiac liposomes are from Nacon Biotechnology Co., Ltd., and are marketed under the name "Stable Guaiac Blue".

[0033] Giant kelp extract is from Guangzhou Haishi Fine Chemical Co., Ltd., and its trade name is SEACTIVE. TM Algae-Clear and Soothing;

[0034] The date seed extract is from Lacus Merey, under the trade name IBR-CalmDeAge;

[0035] The Schisandra chinensis extract is from Draco.

[0036] Unless otherwise specified, all other materials and reagents used in the examples are commercially available.

[0037] The component composition (parts by weight) of the skin care compositions of Examples 1-7 and Comparative Examples 1-8 in this invention is shown below. Each component was weighed according to the formula amount, mixed and homogenized to obtain each composition.

[0038] Example 1

[0039] An anti-pollution composition comprising guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract in a weight ratio of 0.2:0.5:0.7:0.3, wherein the total weight of the guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is 100 parts.

[0040] Example 2

[0041] An anti-pollution composition comprising guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract in a weight ratio of 0.1:0.1:0.6:0.1, wherein the total weight of the guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is 100 parts.

[0042] Example 3

[0043] An anti-pollution composition comprising guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract in a weight ratio of 0.3:1:0.8:0.5, wherein the total weight of the guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is 100 parts.

[0044] Example 4

[0045] An anti-pollution composition comprising guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract in a weight ratio of 0.05:0.05:0.5:0.05, wherein the total weight of the guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is 100 parts.

[0046] Example 5

[0047] An anti-pollution composition comprising guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract in a weight ratio of 0.5:2:1.2:1.5, wherein the total weight of the guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is 100 parts.

[0048] Example 6

[0049] An anti-pollution composition comprising guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract in a weight ratio of 0.01:0.01:2:3, wherein the total weight of the guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is 100 parts.

[0050] Example 7

[0051] An anti-pollution composition comprising guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract in a weight ratio of 1:3:0.1:0.01, wherein the total weight of the guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is 100 parts.

[0052] Comparative Example 1

[0053] The difference between Comparative Example 1 and Example 1 is that: Comparative Example 1 does not add guaiac liposomes, and uses giant kelp extract, date seed extract and schisandra extract in a weight ratio of 0.5:0.7:0.3 to make up for the missing amount.

[0054] Comparative Example 2

[0055] The difference between Comparative Example 2 and Example 1 is that: no giant kelp extract was added in Comparative Example 2, and the missing amount was made up by guaiac liposomes, date seed extract and schisandra extract in a weight ratio of 0.2:0.7:0.3.

[0056] Comparative Example 3

[0057] The difference between Comparative Example 3 and Example 1 is that: no date seed extract was added in Comparative Example 3, and guaiac liposomes, giant kelp extract and Schisandra chinensis extract in a weight ratio of 0.2:0.5:0.3 were used to make up for the missing amount.

[0058] Comparative Example 4

[0059] The difference between Comparative Example 4 and Example 1 is that: no Schisandra chinensis extract was added in Comparative Example 4, and Guaiac liposomes, giant kelp extract and date palm seed extract in a weight ratio of 0.2:0.5:0.7 were used to make up for the missing amount.

[0060] Comparative Example 5

[0061] The difference between Comparative Example 5 and Example 1 is that Comparative Example 5 does not contain guaiac liposomes, but is replaced with an equal amount of bisabolol.

[0062] Comparative Example 6

[0063] The difference between Comparative Example 6 and Example 1 is that no giant kelp extract was added in Comparative Example 6, but an equal amount of Sargassum fusiforme extract was used instead.

[0064] Comparative Example 7

[0065] The difference between Comparative Example 7 and Example 1 is that Comparative Example 7 does not contain date seed extract, but is replaced with an equal amount of grape seed extract.

[0066] Comparative Example 8

[0067] The difference between Comparative Example 8 and Example 1 is that: no Schisandra chinensis extract was added in Comparative Example 8, and an equal amount of Centella asiatica extract was used instead.

[0068] Test Example 1: Inhibitory effect of the composition on inflammation induced by air pollution

[0069] Filagrin (FLG) is a crucial molecule in the stratum corneum of human skin, connecting keratin fibers. With the assistance of FLG monomers, keratin fibers aggregate regularly, forming a robust physical barrier on the outermost layer of the epidermis, thus strengthening the skin. The inflammatory cytokine IL-6 is a pleiotropic cytokine that plays a vital role in host defense by regulating immune and inflammatory responses. It can promote the proliferation and differentiation of various cell types, accelerate the synthesis of acute-phase proteins in hepatocytes, and inhibit the growth of melanoma and breast cancer cells. Polycyclic aromatic hydrocarbons (PAHs) in the air are common environmental pollutants. Benzo(a)pyrene (BaP) is one of the most extensively studied PAHs and a major environmental factor leading to skin damage and inflammation. Therefore, after treatment with the composition, the higher the FLG barrier protein content and the lower the IL-6 content, the stronger the composition's resistance to air pollution. The barrier protection ability of the skincare composition is represented by the improvement in FLG levels, and the anti-inflammatory ability is represented by the improvement in IL-6 levels.

[0070] This study investigates the inhibitory effect of the anti-pollution compositions prepared in Examples 1-7 and Comparative Examples 1-8 on air pollution-induced inflammation and barrier damage.

[0071] The cell line used was human keratinocytes (HaCaT, Beina Biotechnology). The testing conditions were: incubator temperature 37±1℃, humidity 90±5%, carbon dioxide 5±1%. Cells were cultured and treated according to groups, followed by testing. Specific tests included the detection of the inflammatory factor IL-6 and the barrier protein FLG gene. The testing methods are as follows:

[0072] (1) The cell suspension was seeded into a 96-well cell culture plate at a density of 2000 cells / well. 100 μL of DMEM medium was added to each well and the cells were cultured for 24 h.

[0073] (2) Discard the supernatant. Add 100 μL of DMEM medium (2105341, Gibco) containing 1 mM BaP (Sigma-Aldrich, catalog number B1760-500MG) to the control group. Add DMEM medium containing 1 mM BaP and 0.01 wt% of the test samples (the skin care compositions prepared in Examples 1-7 and Comparative Examples 1-8, respectively).

[0074] (3) After incubation for 24 hours, collect the culture medium and cells respectively;

[0075] (4) Detection of barrier protein FLG gene: RNA was extracted from cells using an RNA extraction kit (TRIzol, Thermo Fisher Scientific), and the RNA was reverse transcribed into cDNA using a reverse transcription kit (RevertAid RT, Thermo Fisher Scientific). The synthesized cDNA was used as a template for real-time quantitative PCR (TaqMan, Thermo Fisher Scientific). The expression level of FLG gene in HaCaT cells of each group was detected by real-time quantitative PCR. GAPDH was used as an internal reference gene. The FLG primer sequences used were 5'-TGAAGCCTATGACACCACTGA-3' and 5'-TCCCCTACGCTTTCTTGTCCT-3'. The GAPDH primer sequences used were 5'-ACTTTGTCAAGCTCATTTCC-3' and 5'-TGCAGCGAACTTTATTGATG-3'.

[0076] (5) Detection of inflammatory factor IL-6: The content of inflammatory factor IL-6 released by cells in culture medium was detected using a human IL-6 ELISA kit (EHC007.96, Shenzhen Xinbosheng Biotechnology Co., Ltd.);

[0077] (6) Calculate the FLG improvement rate and IL-6 improvement rate using the following formulas:

[0078] FLG improvement rate = (FLG expression level) 样品组 -FLG 对照组 / FLG expression level 对照组 )×100%;

[0079] IL-6 improvement rate = (1 - IL-6 content) 样品组 / IL-6 content 对照组 )×100%;

[0080] The results are shown in Table 1.

[0081] Test Example 2: Inhibitory effect of the composition on oxidative stress caused by air pollution

[0082] Particulate matter is one of the main pollutants in the air. Air pollution accumulates on the skin surface, triggering a series of oxidative stress reactions, leading to absorption through hair follicles or inhalation and diffusion into the deeper dermis. Once these pollutants enter the skin, they cause an increase in reactive oxygen species (ROS), inducing oxidative stress and potentially leading to the collapse of the defense system and the development of tissue damage. The less ROS generated after treatment with a skincare composition, the stronger the inhibitory effect of the skincare composition on oxidative stress caused by air pollution. The ability of an anti-pollution composition to inhibit oxidative stress is indicated by the improvement in ROS levels.

[0083] This study investigates the inhibitory effect of the anti-pollution compositions prepared in Examples 1-7 and Comparative Examples 1-8 on air pollution-induced oxidative stress.

[0084] The cell line used was human keratinocytes (HaCaT, from Beina Biotechnology). The testing conditions were: incubator temperature 37±1℃, humidity 90±5%, carbon dioxide 5±1%. Cells were cultured and treated according to groups, followed by testing, specifically the content of reactive oxygen species (ROS). The testing method is as follows:

[0085] (1) The cell suspension was seeded into a 96-well cell culture plate at a density of 2000 cells / well. 100 μL of DMEM medium was added to each well and the cells were cultured for 24 h.

[0086] (2) Discard the supernatant. Add 100 μL of DMEM medium (2105341, Gibco) containing 100 μg / mL fine particles (Sigma-Aldrich, catalog number NIST2975) to the control group. Add DMEM medium containing 100 μg / mL particles and 0.01 wt% of the test sample (the skin care compositions prepared in Examples 1-7 and Comparative Examples 1-8, respectively).

[0087] (3) After incubation for 24 hours, collect the culture medium and cells respectively;

[0088] (4) The reactive oxygen species (ROS) assay kit (chemiluminescence method) (ELISA, ml092661) was used to measure the ROS in the model group and the sample group. The procedure was performed according to the instructions of the ROS assay kit (chemiluminescence method, DCFH-DA probe): 100 μL of 10 μM DCFH-DA working solution was added to each well of the control group and the sample group, and incubated at 37°C in the dark for 30 min; the probe solution was discarded, and the sample was washed 3 times with PBS to remove excess probe; the fluorescence intensity (A value) was immediately measured using a fluorescence microplate reader (excitation wavelength 502 nm, emission wavelength 530 nm), and the average value was taken from 3 readings per well.

[0089] (6) Calculate the ROS improvement rate using the following formula:

[0090] ROS improvement rate (%) = (1-ROS) 样品组 / ROS 对照组 )×100%;

[0091] The results are shown in Table 1.

[0092] Table 1. Data on the inhibitory effects of the composition on air pollution-induced inflammation and oxidative stress.

[0093]

[0094]

[0095] The data in Table 1 regarding the improvement rates of FLG, IL-6, and ROS in Examples 1-7 and Comparative Examples 1-8 show that the composition prepared by combining the four components—guaiac liposomes, giant kelp extract, date palm seed extract, and Schisandra chinensis extract—significantly improved the improvement rates of FLG, IL-6, and ROS, indicating a synergistic effect among these four components. The absence or substitution of any one of these four components reduced the overall improvement rate. The anti-pollution effect of the compound; compared with Example 1, Comparative Examples 2 and 3 lacked giant kelp extract and date palm fruit extract, respectively, so their effects on improving FLG were poor; compared with Example 1, Comparative Examples 1 and 4 lacked guaiac liposomes and Schisandra chinensis extract, respectively, so their anti-inflammatory and antioxidant abilities were the worst; in summary, the combination of four components, guaiac liposomes, giant kelp extract, date palm seed extract and Schisandra chinensis extract, can achieve triple protection, thus enhancing the stress-relieving and anti-pollution effects of the composition.

[0096] Application Example 1-7 and Comparative Application Example 1-9

[0097] The compositions of Examples 1-7 and Comparative Examples 1-8 were added to the serum at a concentration of 3 wt% to obtain the serums of Application Examples 1-7 and Comparative Application Examples 1-8. The formulations are shown in Table 2.

[0098] The preparation methods of the serums used in Application Examples 1-7 and Comparative Application Examples 1-8 include the following steps:

[0099] The preparation method of the serum includes the following steps:

[0100] S1. Mix the humectant, thickener and 1 / 2 volume of deionized water, and homogenize at 80°C to obtain an aqueous solution.

[0101] S2. When the temperature of the aqueous solution in S1 drops to 60°C, add the preservative and stir evenly. When the system temperature drops to 40°C, add the components of the skin care composition and the remaining deionized water, stir evenly, and finally add the pH adjuster to adjust the pH to 6 to obtain the essence.

[0102] Table 2. Serum formulations for Application Examples 1-7 and Comparative Application Examples 1-8

[0103]

[0104] Comparative Application Example 9

[0105] The difference between Comparative Application Example 9 and Application Example 1 is that the essence in Comparative Application Example 9 does not contain the composition, but uses an equal amount of deionized water instead of the composition, and the preparation method is the same as that in Application Example 1.

[0106] Test Example 3: Long-lasting soothing and repairing effects on the human body

[0107] Experimental Methods: Volunteers were enrolled according to the general principles of human safety testing methods in the *Cosmetic Safety Technical Specifications*. Forty-eight Asian adults aged 18-60 years who reported sensitive skin were randomly divided into 16 groups of 3 participants each. On the day of their visit, volunteers washed their faces with water without applying any product and sat quietly for 20 minutes in an air-conditioned room with a temperature of 21±1℃ and humidity of 50±10%. The Tewameter™ Hex probe for testing facial cheekbones was used. The CM 825 probe and MX 18 probe were used to measure transcutaneous water loss (TEWL), water content, and erythema index (a* value) of the zygomatic bone.

[0108] Long-term test: Subjects used the serum twice a day, morning and evening, 2 pumps each time, about 1g each time. After 14 days, they were followed up and their zygomatic TEWL, moisture content, and erythema index (a* value) were tested.

[0109] Improvement rate of each value before and after use = |mean value before use - mean value after use| / mean value before use × 100%;

[0110] The calculated data are shown in Table 3 below;

[0111] Table 3 Test data of serums from application examples 1-7 and comparative application examples 1-9

[0112]

[0113]

[0114] As shown in Table 3, the data from Application Examples 1-7 and Comparative Application Examples 1-8 indicate that the TEWL improvement rate, moisture improvement rate, and erythema improvement rate of Application Examples 1-8 prepared by using the combination of four components: guaiac liposomes, giant kelp extract, date seed extract, and schisandra extract are significantly improved. This indicates that the four components of guaiac liposomes, giant kelp extract, date seed extract, and schisandra extract have a synergistic effect, and the composition has an enhanced ability to soothe irritation.

[0115] Test Example 4: The soothing effect on redness and itching caused by allergies to indoor air pollution from home renovations.

[0116] Experimental method: Three volunteers who had skin allergies due to company renovations were recruited. Each volunteer applied 1g of the essence prepared in Example 1 to the allergic area and observed the soothing effect on erythema and itching within 5 minutes.

[0117] The results are as follows Figure 1 As shown, the erythema of all three volunteers was significantly relieved, and all three reported significant relief from itching, indicating that the essence prepared in Example 1 of this application has an excellent soothing effect.

[0118] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. An anti-pollution composition containing guaiac, characterized in that, It comprises the following components: guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract, wherein the weight ratio of guaiac liposomes, giant kelp extract, date palm seed extract, and schisandra chinensis extract is (0.01-1):(0.01-3):(0.1-2):(0.01-3); wherein the giant kelp extract is from Guangzhou Haishi Fine Chemical Co., Ltd., and its trade name is SEACTIVE™ Algae Comfort.

2. The antifouling composition according to claim 1, characterized in that, The weight ratio of the guaiac liposomes, giant kelp extract, date palm seed extract and schisandra chinensis extract is (0.05-0.5):(0.05-2):(0.5-1.2):(0.05-1.5).

3. The anti-fouling composition according to claim 1, characterized in that, The weight ratio of the guaiac liposomes, giant kelp extract, date palm seed extract and schisandra chinensis extract is (0.1-0.3):(0.1-1):(0.6-0.8):(0.1-0.5).

4. The use of the anti-pollution composition according to any one of claims 1-3 in the preparation of skin care products.

5. The use of the anti-pollution composition as described in claim 4 in the preparation of skin care products, characterized in that, The skincare product is any one of toner, lotion, cream, mask, serum or spray, and the amount of the composition added is 0.5%-5% of the total weight of the skincare product.

6. An essence, characterized in that, The raw materials include the following weight percentages: 0.5%-5% of the antifouling composition according to any one of claims 1-3, 0.05%-0.3% of thickener, 0.5%-10% of humectant, 0.5%-1% of preservative and 0.01%-0.3% of pH adjuster, with the balance being deionized water.

7. The essence as described in claim 6, characterized in that, The raw material is selected from at least one of (a)-(d): (a) The thickener comprises at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer and sclerotium gum; (b) The moisturizing agent comprises at least one of allantoin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, sodium hyaluronate, 1,3-butanediol, glycerin, budding stalk polysaccharide and ceramide; (c) The pH adjuster includes at least one of arginine, tromethamine, and disodium EDTA; (d) The preservative includes at least one of 1,3-propanediol, 1,2-hexanediol and p-hydroxyacetophenone.

8. The method for preparing the essence according to claim 6 or 7, characterized in that, Includes the following steps: S1. Mix the humectant, thickener and part of deionized water, and homogenize to obtain an aqueous solution. S2. When the temperature of the aqueous solution in S1 drops to 55-65℃, add the preservative and stir evenly. When the system temperature drops to 38-42℃, add the components of the skin care composition and the remaining deionized water, stir evenly, and finally add the pH adjuster to adjust the pH to obtain the essence.

9. The preparation method according to claim 8, characterized in that, The homogenization temperature in step S1 is 75-85℃.

10. The preparation method according to claim 8, characterized in that, In step S2, the pH is adjusted to 5.5-6.5.

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